HCAR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.53108455
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.53108455
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.53108455
4modulation by symbiont of host immune response (GO:0052553)5.53108455
5positive regulation by symbiont of host defense response (GO:0052509)5.53108455
6modulation by symbiont of host defense response (GO:0052031)5.53108455
7detection of molecule of bacterial origin (GO:0032490)5.29653906
8positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.29322544
9response to peptidoglycan (GO:0032494)5.21136584
10negative regulation of cell killing (GO:0031342)5.19442942
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.19442942
12cellular extravasation (GO:0045123)5.01614010
13detection of other organism (GO:0098543)4.98226307
14macrophage activation involved in immune response (GO:0002281)4.90631348
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.81336817
16negative regulation of interleukin-12 production (GO:0032695)4.80289450
17positive regulation of gamma-delta T cell activation (GO:0046645)4.80115043
18neutrophil activation involved in immune response (GO:0002283)4.75344286
19detection of external biotic stimulus (GO:0098581)4.56984132
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.47874421
21regulation of interferon-beta biosynthetic process (GO:0045357)4.45166689
22detection of bacterium (GO:0016045)4.40675750
23germinal center formation (GO:0002467)4.29330465
24neutrophil activation (GO:0042119)4.28764541
25antigen processing and presentation of endogenous antigen (GO:0019883)4.19435373
26detection of biotic stimulus (GO:0009595)4.13563621
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.06018759
28granulocyte activation (GO:0036230)4.03129096
29neutrophil mediated immunity (GO:0002446)4.00453945
30immunoglobulin mediated immune response (GO:0016064)3.97210411
31production of molecular mediator involved in inflammatory response (GO:0002532)3.94423729
32regulation of T-helper 2 cell differentiation (GO:0045628)3.92162221
33leukocyte aggregation (GO:0070486)3.85257281
34macrophage activation (GO:0042116)3.82188026
35lipopolysaccharide-mediated signaling pathway (GO:0031663)3.81536479
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.76558787
37leukocyte migration involved in inflammatory response (GO:0002523)3.73013749
38type I interferon signaling pathway (GO:0060337)3.71845585
39cellular response to type I interferon (GO:0071357)3.71845585
40regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.71645664
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.71287326
42response to host immune response (GO:0052572)3.71287326
43microglial cell activation (GO:0001774)3.69650769
44response to type I interferon (GO:0034340)3.68243223
45regulation of gamma-delta T cell activation (GO:0046643)3.65699672
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.65117796
47regulation of B cell receptor signaling pathway (GO:0050855)3.65089103
48T-helper 1 type immune response (GO:0042088)3.64509305
49respiratory burst (GO:0045730)3.63583333
50defense response to protozoan (GO:0042832)3.52793988
51negative regulation of T-helper cell differentiation (GO:0045623)3.45084294
52negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.45084294
53myeloid cell activation involved in immune response (GO:0002275)3.38957844
54positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.37437278
55response to host (GO:0075136)3.37195155
56response to host defenses (GO:0052200)3.37195155
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37195155
58myeloid leukocyte mediated immunity (GO:0002444)3.36557257
59response to interleukin-15 (GO:0070672)3.35171479
60neutrophil chemotaxis (GO:0030593)3.33890574
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.32159961
62interferon-gamma-mediated signaling pathway (GO:0060333)3.31995110
63negative regulation of leukocyte mediated immunity (GO:0002704)3.31687474
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.28551303
65regulation of mast cell degranulation (GO:0043304)3.28077342
66positive regulation of acute inflammatory response (GO:0002675)3.26640362
67neutrophil migration (GO:1990266)3.25259599
68negative regulation of cytokine production involved in immune response (GO:0002719)3.24854580
69response to muramyl dipeptide (GO:0032495)3.24321802
70response to protozoan (GO:0001562)3.19561963
71negative regulation of T cell mediated immunity (GO:0002710)3.19012330
72positive regulation of NF-kappaB import into nucleus (GO:0042346)3.17288920
73positive regulation of interferon-alpha production (GO:0032727)3.17187427
74regulation of dendritic cell antigen processing and presentation (GO:0002604)3.17006979
75positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.15491168
76regulation of interferon-alpha production (GO:0032647)3.14876695
77B cell mediated immunity (GO:0019724)3.09857956
78negative regulation of interleukin-6 production (GO:0032715)3.05648051
79positive regulation of type 2 immune response (GO:0002830)3.05339316
80regulation of interleukin-8 biosynthetic process (GO:0045414)3.03089664
81negative regulation of type 2 immune response (GO:0002829)3.02262258
82regulation of mast cell activation involved in immune response (GO:0033006)3.00912205
83positive regulation of toll-like receptor signaling pathway (GO:0034123)2.98481240
84regulation of tolerance induction (GO:0002643)2.97078456
85regulation of mast cell activation (GO:0033003)2.96484005
86JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96114696
87regulation of T cell tolerance induction (GO:0002664)2.95246362
88regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94733078
89positive regulation of mast cell activation (GO:0033005)2.94437724
90myeloid leukocyte activation (GO:0002274)2.92069937
91cellular response to interleukin-15 (GO:0071350)2.91924551
92regulation of type 2 immune response (GO:0002828)2.90040296
93negative regulation of alpha-beta T cell activation (GO:0046636)2.87728058
94cytokine secretion (GO:0050663)2.86718913
95positive regulation of interleukin-10 production (GO:0032733)2.85090211
96granulocyte chemotaxis (GO:0071621)2.85018725
97negative regulation of toll-like receptor signaling pathway (GO:0034122)2.83409364
98positive regulation of cellular amide metabolic process (GO:0034250)2.83151545
99regulation of leukocyte degranulation (GO:0043300)2.83031788
100regulation of toll-like receptor signaling pathway (GO:0034121)2.81153531

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.49264611
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.38438104
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.47119562
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.73451156
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48463745
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39411900
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.38836886
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.35198002
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05231115
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.87728023
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.87351102
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78536269
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.75655228
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.73575896
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71303549
16VDR_24763502_ChIP-Seq_THP-1_Human2.50233129
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.44347062
18RUNX_20019798_ChIP-Seq_JUKART_Human2.43891775
19SPI1_23547873_ChIP-Seq_NB4_Human2.39311550
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32638119
21SPI1_23127762_ChIP-Seq_K562_Human2.30452749
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23233972
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20999537
24VDR_21846776_ChIP-Seq_THP-1_Human2.19447450
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17427850
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17369834
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03441839
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.01230103
29MAF_26560356_Chip-Seq_TH1_Human1.98324619
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97018183
31MYB_26560356_Chip-Seq_TH2_Human1.96939747
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.95650740
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94741894
34VDR_24787735_ChIP-Seq_THP-1_Human1.93077364
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90806139
36SCL_19346495_ChIP-Seq_HPC-7_Human1.87940822
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.81932057
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79322539
39UTX_26944678_Chip-Seq_JUKART_Human1.75366500
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73672654
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73539721
42TCF7_22412390_ChIP-Seq_EML_Mouse1.70681787
43MYB_26560356_Chip-Seq_TH1_Human1.67152903
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61388063
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53134751
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51629729
47KDM2B_26808549_Chip-Seq_DND41_Human1.44115492
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43744654
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43616487
50MYC_22102868_ChIP-Seq_BL_Human1.43174177
51GATA3_27048872_Chip-Seq_THYMUS_Human1.38974911
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37763440
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35832955
54PU_27001747_Chip-Seq_BMDM_Mouse1.34400137
55MAF_26560356_Chip-Seq_TH2_Human1.33684142
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33317833
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.33051273
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30734601
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28756975
60GATA3_26560356_Chip-Seq_TH2_Human1.28264550
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25262754
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24759520
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24704022
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22603376
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.21486365
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.21040260
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20858585
68GATA1_22025678_ChIP-Seq_K562_Human1.20416204
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17958236
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17075726
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14534231
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13878162
73EGR1_19032775_ChIP-ChIP_M12_Human1.13181494
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12977475
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11253243
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08761019
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08311553
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05764834
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04002534
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03105533
81LXR_22292898_ChIP-Seq_THP-1_Human1.03095415
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00227521
83PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97891132
84GATA1_19941826_ChIP-Seq_K562_Human0.97861839
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96333142
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92779552
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92779552
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92779552
89KDM2B_26808549_Chip-Seq_JURKAT_Human0.92614293
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91989349
91GATA2_19941826_ChIP-Seq_K562_Human0.85060182
92TP63_17297297_ChIP-ChIP_HaCaT_Human0.84392647
93BCL6_27268052_Chip-Seq_Bcells_Human0.82798160
94BCOR_27268052_Chip-Seq_Bcells_Human0.81074290
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79643191
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.79330036
97NCOR1_26117541_ChIP-Seq_K562_Human0.75907045
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73145292
99KDM2B_26808549_Chip-Seq_K562_Human0.70976984
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.70366234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to6.45652937
2MP0003303_peritoneal_inflammation5.80942750
3MP0003436_decreased_susceptibility_to4.20089733
4MP0001835_abnormal_antigen_presentation3.32302359
5MP0002419_abnormal_innate_immunity3.02007031
6MP0009785_altered_susceptibility_to2.90590340
7MP0005000_abnormal_immune_tolerance2.77231851
8MP0005025_abnormal_response_to2.74508624
9MP0009278_abnormal_bone_marrow2.68886483
10MP0002148_abnormal_hypersensitivity_rea2.62948998
11MP0005387_immune_system_phenotype2.62101467
12MP0001790_abnormal_immune_system2.62101467
13MP0006082_CNS_inflammation2.59288885
14MP0001800_abnormal_humoral_immune2.58220016
15MP0005671_abnormal_response_to2.43921918
16MP0001533_abnormal_skeleton_physiology2.43593898
17MP0000685_abnormal_immune_system2.41685021
18MP0002723_abnormal_immune_serum2.41571030
19MP0002452_abnormal_antigen_presenting2.31270942
20MP0008004_abnormal_stomach_pH2.27738672
21MP0002420_abnormal_adaptive_immunity2.19045381
22MP0001819_abnormal_immune_cell2.18024261
23MP0003300_gastrointestinal_ulcer2.17088440
24MP0009764_decreased_sensitivity_to2.17021451
25MP0003191_abnormal_cellular_cholesterol2.09695262
26MP0004947_skin_inflammation1.98477805
27MP0003075_altered_response_to1.92279118
28MP0002405_respiratory_system_inflammati1.85867306
29MP0010155_abnormal_intestine_physiology1.83614182
30MP0004510_myositis1.81748581
31MP0005451_abnormal_body_composition1.76876098
32MP0001845_abnormal_inflammatory_respons1.75569323
33MP0005464_abnormal_platelet_physiology1.74347763
34MP0002132_abnormal_respiratory_system1.68756424
35MP0002277_abnormal_respiratory_mucosa1.62094986
36MP0005397_hematopoietic_system_phenotyp1.61411430
37MP0001545_abnormal_hematopoietic_system1.61411430
38MP0003828_pulmonary_edema1.57288464
39MP0000465_gastrointestinal_hemorrhage1.54551691
40MP0000716_abnormal_immune_system1.54369517
41MP0008260_abnormal_autophagy1.53768539
42MP0002398_abnormal_bone_marrow1.46978021
43MP0008469_abnormal_protein_level1.45646877
44MP0005166_decreased_susceptibility_to1.45196707
45MP0005164_abnormal_response_to1.37777161
46MP0000858_altered_metastatic_potential1.30948800
47MP0003763_abnormal_thymus_physiology1.28362269
48MP0001853_heart_inflammation1.27295415
49MP0009333_abnormal_splenocyte_physiolog1.26652457
50MP0003172_abnormal_lysosome_physiology1.25508777
51MP0002998_abnormal_bone_remodeling1.22723782
52MP0002722_abnormal_immune_system1.20866478
53MP0000343_altered_response_to1.19566220
54MP0002429_abnormal_blood_cell1.18525642
55MP0003448_altered_tumor_morphology1.16796021
56MP0004883_abnormal_blood_vessel1.16485922
57MP0000689_abnormal_spleen_morphology1.15587059
58MP0005310_abnormal_salivary_gland1.14662618
59MP0003866_abnormal_defecation1.14335767
60MP0001851_eye_inflammation1.14055070
61MP0003045_fibrosis1.10288471
62MP0002332_abnormal_exercise_endurance1.10104825
63MP0005390_skeleton_phenotype1.05426569
64MP0005167_abnormal_blood-brain_barrier1.02199280
65MP0003690_abnormal_glial_cell0.97380879
66MP0001663_abnormal_digestive_system0.95620601
67MP0003656_abnormal_erythrocyte_physiolo0.94054251
68MP0009765_abnormal_xenobiotic_induced0.93223270
69MP0003183_abnormal_peptide_metabolism0.90247563
70MP0004381_abnormal_hair_follicle0.89183466
71MP0010352_gastrointestinal_tract_polyps0.88921825
72MP0009763_increased_sensitivity_to0.88640985
73MP0005058_abnormal_lysosome_morphology0.87627760
74MP0000703_abnormal_thymus_morphology0.87409078
75MP0003806_abnormal_nucleotide_metabolis0.85783831
76MP0000604_amyloidosis0.79292742
77MP0003453_abnormal_keratinocyte_physiol0.79103722
78MP0002138_abnormal_hepatobiliary_system0.77633764
79MP0002006_tumorigenesis0.76873879
80MP0009840_abnormal_foam_cell0.75818036
81MP0002396_abnormal_hematopoietic_system0.75049820
82MP0003221_abnormal_cardiomyocyte_apopto0.71317308
83MP0002166_altered_tumor_susceptibility0.69973214
84MP0004808_abnormal_hematopoietic_stem0.69810056
85MP0000249_abnormal_blood_vessel0.68128869
86MP0004858_abnormal_nervous_system0.65372067
87MP0008874_decreased_physiological_sensi0.63683541
88MP0002254_reproductive_system_inflammat0.62203709
89MP0003795_abnormal_bone_structure0.58105717
90MP0004484_altered_response_of0.57270385
91MP0001873_stomach_inflammation0.57250229
92MP0002933_joint_inflammation0.56702570
93MP0005535_abnormal_body_temperature0.54430167
94MP0005381_digestive/alimentary_phenotyp0.53058203
95MP0000750_abnormal_muscle_regeneration0.52258282
96MP0005319_abnormal_enzyme/_coenzyme0.51324526
97MP0006054_spinal_hemorrhage0.50065255
98MP0005023_abnormal_wound_healing0.48444439
99MP0003091_abnormal_cell_migration0.48165451
100MP0005377_hearing/vestibular/ear_phenot0.47787627

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)6.71143130
2Myositis (HP:0100614)6.48186720
3Optic neuritis (HP:0100653)6.38100576
4Retrobulbar optic neuritis (HP:0100654)6.38100576
5Eczematoid dermatitis (HP:0000976)6.20163540
6Recurrent bacterial skin infections (HP:0005406)5.66012216
7Abnormality of macrophages (HP:0004311)5.50620653
8Recurrent abscess formation (HP:0002722)5.49677405
9Stomatitis (HP:0010280)5.40996474
10Elevated erythrocyte sedimentation rate (HP:0003565)4.99196806
11Keratoconjunctivitis sicca (HP:0001097)4.73161358
12Recurrent gram-negative bacterial infections (HP:0005420)4.44958900
13Keratoconjunctivitis (HP:0001096)4.35293721
14Gastrointestinal infarctions (HP:0005244)4.26293284
15Mediastinal lymphadenopathy (HP:0100721)4.23704829
16Increased IgE level (HP:0003212)4.02358239
17Vasculitis (HP:0002633)3.85302939
18Meningitis (HP:0001287)3.81065254
19Obstructive lung disease (HP:0006536)3.72936484
20Chronic obstructive pulmonary disease (HP:0006510)3.72936484
21Recurrent fungal infections (HP:0002841)3.70429783
22Recurrent skin infections (HP:0001581)3.66291407
23Encephalitis (HP:0002383)3.60445086
24Urticaria (HP:0001025)3.56913274
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.52038589
26Gangrene (HP:0100758)3.49780081
27Hemoptysis (HP:0002105)3.40056654
28Peritonitis (HP:0002586)3.34641181
29Episodic fever (HP:0001954)3.34593647
30Spontaneous hematomas (HP:0007420)3.33447223
31Amyloidosis (HP:0011034)3.33006948
32Pulmonary infiltrates (HP:0002113)3.23371253
33Arterial thrombosis (HP:0004420)3.23193229
34Gingivitis (HP:0000230)3.22785243
35Anorexia (HP:0002039)3.14249877
36Chest pain (HP:0100749)3.06997098
37Chronic mucocutaneous candidiasis (HP:0002728)3.06870518
38Recurrent cutaneous fungal infections (HP:0011370)3.06870518
39Leukocytosis (HP:0001974)2.97207560
40Pulmonary embolism (HP:0002204)2.84400098
41Abnormality of the pleura (HP:0002103)2.79628332
42Abnormality of the peritoneum (HP:0002585)2.78968779
43Cellulitis (HP:0100658)2.78311207
44Gingival bleeding (HP:0000225)2.71268360
45Increased IgM level (HP:0003496)2.67825322
46Abnormality of T cell number (HP:0011839)2.59290360
47T lymphocytopenia (HP:0005403)2.58369153
48Prolonged bleeding time (HP:0003010)2.56392059
49Abnormality of glycolipid metabolism (HP:0010969)2.51545011
50Abnormality of liposaccharide metabolism (HP:0010968)2.51545011
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.51545011
52Recurrent viral infections (HP:0004429)2.44143344
53Segmental peripheral demyelination/remyelination (HP:0003481)2.43465830
54Hypochromic anemia (HP:0001931)2.41194078
55Abnormality of the endocardium (HP:0004306)2.40865465
56Inflammation of the large intestine (HP:0002037)2.40651127
57Hypergammaglobulinemia (HP:0010702)2.39597298
58Sepsis (HP:0100806)2.38759596
59Glomerulopathy (HP:0100820)2.36542414
60Hypochromic microcytic anemia (HP:0004840)2.32683422
61Keratitis (HP:0000491)2.31837689
62Pustule (HP:0200039)2.29251883
63Epistaxis (HP:0000421)2.29192732
64Premature loss of primary teeth (HP:0006323)2.29103974
65Vertigo (HP:0002321)2.28627406
66Gastrointestinal inflammation (HP:0004386)2.27141307
67Granulocytopenia (HP:0001913)2.26553073
68Acne (HP:0001061)2.23293493
69Osteomyelitis (HP:0002754)2.22390411
70Autoimmune thrombocytopenia (HP:0001973)2.22285850
71Systemic lupus erythematosus (HP:0002725)2.21940539
72Loss of speech (HP:0002371)2.20001972
73Abnormality of the pericardium (HP:0001697)2.19259048
74Petechiae (HP:0000967)2.18882626
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15797695
76Abnormality of T cells (HP:0002843)2.15033088
77Polyneuropathy (HP:0001271)2.09539806
78Interstitial pulmonary disease (HP:0006530)2.07690548
79Eosinophilia (HP:0001880)2.07208558
80Chronic otitis media (HP:0000389)2.05501133
81Increased serum ferritin (HP:0003281)2.03831358
82Increased cerebral lipofuscin (HP:0011813)2.02300682
83Skin ulcer (HP:0200042)1.99764531
84Colitis (HP:0002583)1.98928399
85Purpura (HP:0000979)1.95983064
86Autoimmune hemolytic anemia (HP:0001890)1.91848250
87Skin rash (HP:0000988)1.91186692
88Thrombophlebitis (HP:0004418)1.91041389
89Recurrent bronchitis (HP:0002837)1.90981954
90Abnormality of cells of the lymphoid lineage (HP:0012140)1.90378013
91Cheilitis (HP:0100825)1.88841055
92Disinhibition (HP:0000734)1.87118706
93Abnormality of T cell physiology (HP:0011840)1.86058926
94Slow saccadic eye movements (HP:0000514)1.85903931
95Malnutrition (HP:0004395)1.85075459
96Joint swelling (HP:0001386)1.84089593
97Abnormality of iron homeostasis (HP:0011031)1.84042927
98Arthralgia (HP:0002829)1.83434526
99Lymphopenia (HP:0001888)1.82873801
100Hepatosplenomegaly (HP:0001433)1.80380324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.54417707
2IRAK43.64297194
3MAP4K13.55969725
4BLK3.26518370
5ERN13.23153499
6TYK22.77835899
7MAP2K32.64268948
8TXK2.61154060
9CSK2.58151953
10EPHB12.35891182
11ZAP702.26270400
12MAP3K142.15317140
13IRAK32.13222166
14TAOK12.00063942
15IKBKE1.96605977
16IRAK11.92763817
17MAP3K31.88209354
18FES1.84177475
19JAK31.83317309
20GRK61.77754397
21TBK11.76338996
22TNK21.72450028
23MAP3K111.72133436
24JAK21.71601494
25PRPF4B1.71082268
26FGR1.66577381
27IRAK21.66420895
28MAP3K11.59195334
29MATK1.58248242
30HCK1.55287017
31BMPR21.39956349
32BTK1.38102163
33SYK1.37780046
34SIK31.35594308
35LYN1.34623235
36TAOK31.31106137
37JAK11.30923004
38KSR21.28632775
39TAOK21.21757038
40IKBKB1.19609028
41EPHA31.18634190
42MAP3K131.14321060
43CDC42BPA1.01000857
44LCK0.96831530
45YES10.96824035
46KIT0.96613084
47MARK30.92336164
48GRK70.89014370
49RIPK10.82640464
50MARK20.81951384
51TGFBR20.80637338
52MAP3K20.78299146
53FGFR40.78166061
54CSF1R0.77880539
55MAP3K60.77578807
56MAP3K50.74016889
57PRKD20.71686590
58PTK60.71303577
59SIK20.70456633
60PDK10.69651235
61PDPK10.66830662
62FGFR30.64122863
63STK100.63823416
64MAPK70.63005997
65ITK0.59862197
66TESK20.57822584
67FYN0.57795947
68MAP2K40.54746943
69HIPK20.52459284
70TRIB30.51450227
71CHUK0.51132301
72SIK10.50386965
73MOS0.48367019
74MAP2K60.48346623
75PIK3CG0.47682802
76PRKG20.45634974
77DAPK20.45594020
78PTK2B0.45244301
79MAPK120.44996908
80TEC0.44777155
81CDK190.44009402
82NLK0.42833171
83STK110.40719490
84MAP3K70.40342038
85PIM10.39623214
86MAPKAPK20.39528539
87KSR10.38934025
88DYRK1B0.37627019
89LRRK20.37067329
90RAF10.36761258
91SMG10.36562995
92SGK30.36431520
93RPS6KC10.35885531
94RPS6KL10.35885531
95ACVR1B0.35582171
96RET0.34341164
97WNK10.33726629
98ALK0.32670691
99PRKCZ0.32234415
100STK380.30958261

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.17789056
2Osteoclast differentiation_Homo sapiens_hsa043803.11513574
3Staphylococcus aureus infection_Homo sapiens_hsa051503.02541099
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.51837292
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.47371819
6Malaria_Homo sapiens_hsa051442.31852760
7Graft-versus-host disease_Homo sapiens_hsa053322.25478822
8Tuberculosis_Homo sapiens_hsa051522.24960800
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.18340353
10Allograft rejection_Homo sapiens_hsa053302.16387111
11Legionellosis_Homo sapiens_hsa051342.11945962
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07005981
13TNF signaling pathway_Homo sapiens_hsa046681.91779364
14Autoimmune thyroid disease_Homo sapiens_hsa053201.85433211
15B cell receptor signaling pathway_Homo sapiens_hsa046621.85153660
16Influenza A_Homo sapiens_hsa051641.81229162
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77196005
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76646331
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75044759
20Type I diabetes mellitus_Homo sapiens_hsa049401.71485691
21Pertussis_Homo sapiens_hsa051331.71063980
22African trypanosomiasis_Homo sapiens_hsa051431.70562368
23Measles_Homo sapiens_hsa051621.70505814
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.64253910
25Chemokine signaling pathway_Homo sapiens_hsa040621.63753096
26Toxoplasmosis_Homo sapiens_hsa051451.61861226
27Rheumatoid arthritis_Homo sapiens_hsa053231.56766347
28Hematopoietic cell lineage_Homo sapiens_hsa046401.56501209
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.52669009
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48433682
31Acute myeloid leukemia_Homo sapiens_hsa052211.43605398
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41558300
33Salmonella infection_Homo sapiens_hsa051321.39170633
34Asthma_Homo sapiens_hsa053101.36667686
35Herpes simplex infection_Homo sapiens_hsa051681.34931517
36Hepatitis C_Homo sapiens_hsa051601.31389437
37Phagosome_Homo sapiens_hsa041451.30793033
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.28893135
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27589782
40Antigen processing and presentation_Homo sapiens_hsa046121.26646184
41Primary immunodeficiency_Homo sapiens_hsa053401.24961455
42Viral myocarditis_Homo sapiens_hsa054161.24133165
43Hepatitis B_Homo sapiens_hsa051611.19664966
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18782938
45T cell receptor signaling pathway_Homo sapiens_hsa046601.18433189
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06178308
47Shigellosis_Homo sapiens_hsa051311.04772341
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00636846
49Prolactin signaling pathway_Homo sapiens_hsa049171.00308004
50Amoebiasis_Homo sapiens_hsa051460.98990954
51VEGF signaling pathway_Homo sapiens_hsa043700.94058268
52Other glycan degradation_Homo sapiens_hsa005110.93568601
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.91914950
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.91843558
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89273956
56Apoptosis_Homo sapiens_hsa042100.88526616
57Platelet activation_Homo sapiens_hsa046110.82133685
58Non-small cell lung cancer_Homo sapiens_hsa052230.81055650
59Lysosome_Homo sapiens_hsa041420.78036377
60Pancreatic cancer_Homo sapiens_hsa052120.77051979
61Chronic myeloid leukemia_Homo sapiens_hsa052200.71698629
62Dorso-ventral axis formation_Homo sapiens_hsa043200.71241443
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.70246315
64Renal cell carcinoma_Homo sapiens_hsa052110.68446258
65Type II diabetes mellitus_Homo sapiens_hsa049300.68433575
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66522437
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.61782473
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61316994
69Notch signaling pathway_Homo sapiens_hsa043300.60151494
70Bladder cancer_Homo sapiens_hsa052190.59305128
71FoxO signaling pathway_Homo sapiens_hsa040680.58721895
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57909808
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.57422241
74Endocytosis_Homo sapiens_hsa041440.56096556
75Epstein-Barr virus infection_Homo sapiens_hsa051690.54984268
76HIF-1 signaling pathway_Homo sapiens_hsa040660.54796038
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54090782
78Insulin resistance_Homo sapiens_hsa049310.53061271
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52385340
80Complement and coagulation cascades_Homo sapiens_hsa046100.51297819
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49017318
82GnRH signaling pathway_Homo sapiens_hsa049120.48879771
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.46930403
84Viral carcinogenesis_Homo sapiens_hsa052030.46111225
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44406856
86MAPK signaling pathway_Homo sapiens_hsa040100.43671018
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41535106
88Choline metabolism in cancer_Homo sapiens_hsa052310.41362400
89Prion diseases_Homo sapiens_hsa050200.41069189
90HTLV-I infection_Homo sapiens_hsa051660.38831428
91Endometrial cancer_Homo sapiens_hsa052130.37624695
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36888631
93Arachidonic acid metabolism_Homo sapiens_hsa005900.33940403
94Rap1 signaling pathway_Homo sapiens_hsa040150.32593486
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31366705
96ErbB signaling pathway_Homo sapiens_hsa040120.30590904
97Insulin signaling pathway_Homo sapiens_hsa049100.28761249
98mTOR signaling pathway_Homo sapiens_hsa041500.26299910
99Prostate cancer_Homo sapiens_hsa052150.25434317
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23785839

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