HBEGF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)5.34122763
2positive regulation of endothelial cell apoptotic process (GO:2000353)5.23637099
3chondrocyte proliferation (GO:0035988)5.16851614
4response to peptidoglycan (GO:0032494)4.94115215
5hemidesmosome assembly (GO:0031581)4.70718547
6atrioventricular valve morphogenesis (GO:0003181)4.64235289
7* wound healing, spreading of epidermal cells (GO:0035313)4.57437274
8mesodermal cell differentiation (GO:0048333)4.31614646
9skin morphogenesis (GO:0043589)4.30800845
10* wound healing, spreading of cells (GO:0044319)4.22127021
11cellular extravasation (GO:0045123)4.12434994
12desmosome organization (GO:0002934)4.00143475
13cellular response to arsenic-containing substance (GO:0071243)3.95533475
14endodermal cell differentiation (GO:0035987)3.93983926
15positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.93880243
16regulation of vitamin D biosynthetic process (GO:0060556)3.91019836
17protein localization to endosome (GO:0036010)3.90802613
18positive regulation of osteoblast proliferation (GO:0033690)3.84404442
19collagen fibril organization (GO:0030199)3.74798295
20lung vasculature development (GO:0060426)3.69224487
21neutrophil activation involved in immune response (GO:0002283)3.57670654
22endothelial cell morphogenesis (GO:0001886)3.53633072
23cell migration involved in sprouting angiogenesis (GO:0002042)3.50615465
24positive regulation of astrocyte differentiation (GO:0048711)3.49398276
25positive regulation of p38MAPK cascade (GO:1900745)3.47782209
26lipopolysaccharide-mediated signaling pathway (GO:0031663)3.47043076
27regulation of integrin-mediated signaling pathway (GO:2001044)3.46973368
28membrane raft organization (GO:0031579)3.42707271
29retina vasculature morphogenesis in camera-type eye (GO:0061299)3.39688502
30cell-substrate junction assembly (GO:0007044)3.39376119
31lymphangiogenesis (GO:0001946)3.38367845
32oligosaccharide catabolic process (GO:0009313)3.36397649
33glycosphingolipid catabolic process (GO:0046479)3.36353418
34cellular response to thyroid hormone stimulus (GO:0097067)3.31509181
35barbed-end actin filament capping (GO:0051016)3.27209794
36positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.27131054
37response to muramyl dipeptide (GO:0032495)3.26766624
38vascular endothelial growth factor signaling pathway (GO:0038084)3.22612831
39plasma membrane repair (GO:0001778)3.21767084
40pinocytosis (GO:0006907)3.21300070
41positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.20259145
42regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.15273651
43heart valve morphogenesis (GO:0003179)3.14017628
44negative regulation of fatty acid transport (GO:2000192)3.13500468
45negative regulation of smooth muscle cell migration (GO:0014912)3.13222463
46positive regulation of blood vessel endothelial cell migration (GO:0043536)3.13171836
47endothelial cell chemotaxis (GO:0035767)3.10002732
48neural crest cell development (GO:0014032)3.08853420
49epithelial cell-cell adhesion (GO:0090136)3.08507750
50regulation of p38MAPK cascade (GO:1900744)3.08460177
51endocardial cushion development (GO:0003197)3.07345075
52regulation of mononuclear cell migration (GO:0071675)3.05484066
53positive regulation of extracellular matrix organization (GO:1903055)3.05055671
54sequestering of extracellular ligand from receptor (GO:0035581)3.03664734
55endothelium development (GO:0003158)3.02466762
56glycolipid catabolic process (GO:0019377)2.99002862
57keratinocyte proliferation (GO:0043616)2.97715429
58negative regulation of interleukin-12 production (GO:0032695)2.95819502
59glial cell migration (GO:0008347)2.95729309
60positive regulation of odontogenesis (GO:0042482)2.95243655
61hypotonic response (GO:0006971)2.94496676
62fibroblast migration (GO:0010761)2.93831601
63angiogenesis involved in wound healing (GO:0060055)2.92550616
64cellular response to vitamin D (GO:0071305)2.92370972
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91736502
66regulation of vitamin metabolic process (GO:0030656)2.91497504
67positive regulation of epithelial to mesenchymal transition (GO:0010718)2.90975904
68positive regulation of cartilage development (GO:0061036)2.90941410
69positive regulation of leukocyte degranulation (GO:0043302)2.89012732
70response to laminar fluid shear stress (GO:0034616)2.88895306
71response to gravity (GO:0009629)2.87506696
72negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.87437828
73lymph vessel development (GO:0001945)2.87096829
74positive regulation of monocyte chemotaxis (GO:0090026)2.86515874
75mRNA transcription (GO:0009299)2.84676635
76regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.84420566
77basement membrane organization (GO:0071711)2.84295213
78interferon-gamma secretion (GO:0072643)2.83724997
79dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.83266063
80protein localization to cell surface (GO:0034394)2.83244134
81regulation of tight junction assembly (GO:2000810)2.82012118
82negative regulation of nitric oxide biosynthetic process (GO:0045019)2.78887806
83Notch signaling involved in heart development (GO:0061314)2.78875549
84substrate adhesion-dependent cell spreading (GO:0034446)2.78009094
85glomerular visceral epithelial cell development (GO:0072015)2.77326484
86blood vessel endothelial cell migration (GO:0043534)2.77160582
87regulation of membrane protein ectodomain proteolysis (GO:0051043)2.76943329
88positive regulation of collagen biosynthetic process (GO:0032967)2.76574427
89regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.76547544
90chemical homeostasis within a tissue (GO:0048875)2.74236009
91negative regulation of interleukin-8 production (GO:0032717)2.73938367
92establishment of endothelial barrier (GO:0061028)2.73315906
93regulation of chemokine secretion (GO:0090196)2.73142594
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.70691953
95regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.68922651
96renal filtration (GO:0097205)2.68319741
97positive regulation of chemokine biosynthetic process (GO:0045080)2.67664162
98regulation of glomerular filtration (GO:0003093)2.65289904
99regulation of podosome assembly (GO:0071801)2.65125769
100monocyte chemotaxis (GO:0002548)2.64280902
101positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.64191423
102regulation of endothelial cell apoptotic process (GO:2000351)2.64076750
103hippo signaling (GO:0035329)2.64030094
104regulation of plasminogen activation (GO:0010755)2.63453929
105response to progesterone (GO:0032570)2.63316456
106notochord development (GO:0030903)2.63054267
107blood vessel remodeling (GO:0001974)2.62255892
108positive regulation of endothelial cell migration (GO:0010595)2.60795689
109cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.59609772
110germinal center formation (GO:0002467)2.58877508
111regulation of cardioblast differentiation (GO:0051890)2.58807030
112granulocyte activation (GO:0036230)2.58215126
113negative regulation of smooth muscle cell differentiation (GO:0051151)2.57469683
114positive regulation of collagen metabolic process (GO:0010714)2.57088955
115negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.56582767
116regulation of monocyte chemotaxis (GO:0090025)2.56548834
117stress fiber assembly (GO:0043149)2.56163455
118regulation of macrophage chemotaxis (GO:0010758)2.55783252
119regulation of collagen biosynthetic process (GO:0032965)2.55574803
120response to thyroid hormone (GO:0097066)2.55045316
121decidualization (GO:0046697)2.54412281
122surfactant homeostasis (GO:0043129)2.54379340
123response to fluid shear stress (GO:0034405)2.54351734
124collagen metabolic process (GO:0032963)2.53938409
125negative regulation of catenin import into nucleus (GO:0035414)2.53517524
126positive regulation of interleukin-6 production (GO:0032755)2.53355522
127regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.53321112
128mesenchymal-epithelial cell signaling (GO:0060638)2.53259511
129negative regulation of lipid storage (GO:0010888)2.53043856
130apoptotic cell clearance (GO:0043277)2.52733386
131glomerular basement membrane development (GO:0032836)2.52386250
132neutrophil chemotaxis (GO:0030593)2.52130345
133positive regulation of stem cell differentiation (GO:2000738)2.52101514
134positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.51913052
135vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.51675359
136regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.51397368
137hyaluronan catabolic process (GO:0030214)2.51115842
138glomerular epithelial cell development (GO:0072310)2.51013257
139extracellular matrix disassembly (GO:0022617)2.50612608
140regulation of collagen metabolic process (GO:0010712)2.50385007
141substrate-dependent cell migration (GO:0006929)2.50017444
142ceramide catabolic process (GO:0046514)2.49776151
143regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.49304920
144regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.49294001
145regulation of interleukin-8 secretion (GO:2000482)2.49129107
146regulation of T-helper 2 cell differentiation (GO:0045628)2.48832421
147macrophage activation (GO:0042116)2.48760837
148regulation of transforming growth factor beta1 production (GO:0032908)2.48042525
149dermatan sulfate biosynthetic process (GO:0030208)2.47994858
150regulation of chemokine biosynthetic process (GO:0045073)2.47700693
151negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.47284800
152cardiac epithelial to mesenchymal transition (GO:0060317)2.47050463
153negative regulation of anoikis (GO:2000811)2.46587277
154negative regulation of stem cell proliferation (GO:2000647)2.45954074
155* positive regulation of epithelial cell migration (GO:0010634)2.45632618
156granulocyte chemotaxis (GO:0071621)2.44880666
157neutrophil migration (GO:1990266)2.44751495
158regulation of leukocyte degranulation (GO:0043300)2.42835769
159cellular copper ion homeostasis (GO:0006878)2.42537126
160macrophage activation involved in immune response (GO:0002281)2.42524424
161regulation of mast cell degranulation (GO:0043304)2.42470361
162regulation of nitric oxide biosynthetic process (GO:0045428)2.39213620
163cellular response to zinc ion (GO:0071294)2.37522551
164negative regulation of blood vessel endothelial cell migration (GO:0043537)2.37112552
165interleukin-1-mediated signaling pathway (GO:0070498)2.36717490
166regulation of interleukin-6 production (GO:0032675)2.36045847
167granulocyte migration (GO:0097530)2.35987787
168regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.35737742
169detection of molecule of bacterial origin (GO:0032490)2.33081742
170positive regulation of mast cell degranulation (GO:0043306)2.32527555
171positive regulation of mast cell activation involved in immune response (GO:0033008)2.32527555
172cellular response to lipopolysaccharide (GO:0071222)2.31846396
173positive regulation of mast cell activation (GO:0033005)2.29658510
174mRNA transcription from RNA polymerase II promoter (GO:0042789)2.29103925
175regulation of macrophage cytokine production (GO:0010935)2.27526884
176regulation of interleukin-8 biosynthetic process (GO:0045414)2.26734275
177positive regulation of nitric oxide biosynthetic process (GO:0045429)2.26211870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.91769956
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.28116810
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.41668536
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.17377174
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.74004130
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.12125130
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.88991923
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.69120197
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63743733
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52611572
11* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.52059137
12* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.52059137
13CJUN_26792858_Chip-Seq_BT549_Human2.44946499
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35220682
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30240906
16CLOCK_20551151_ChIP-Seq_293T_Human2.27894467
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.25207969
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.24029758
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.20873642
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.09347831
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.06714467
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98461046
23RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89028554
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.88450828
25* SOX2_20726797_ChIP-Seq_SW620_Human1.86886698
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86488327
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.85323535
28* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.84934865
29JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84799600
30VDR_24763502_ChIP-Seq_THP-1_Human1.84191096
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.83142764
32ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.82785359
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.80469978
34CDX2_20551321_ChIP-Seq_CACO-2_Human1.79419172
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79201028
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69747597
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69738592
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.65901959
39JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65226454
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64045137
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61381142
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61381142
43TP53_18474530_ChIP-ChIP_U2OS_Human1.61307150
44BRD4_25478319_ChIP-Seq_HGPS_Human1.61218586
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.59332024
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57356318
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57295698
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57025106
49* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55506400
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55345094
51VDR_21846776_ChIP-Seq_THP-1_Human1.51428338
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50692704
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49900521
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45605901
55* ATF3_27146783_Chip-Seq_COLON_Human1.44536442
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42345538
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.40438363
58TP53_16413492_ChIP-PET_HCT116_Human1.39492375
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.38222985
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.36951444
61UBF1/2_26484160_Chip-Seq_HMECs_Human1.36666534
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36165790
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36128694
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34302354
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34152762
66P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32921553
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31871843
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.30827950
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28252013
70* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26834926
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.26591368
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.26578873
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22196118
74KLF5_25053715_ChIP-Seq_YYC3_Human1.21627430
75SMC1_22415368_ChIP-Seq_MEFs_Mouse1.21557485
76SPI1_23127762_ChIP-Seq_K562_Human1.20456570
77LXR_22292898_ChIP-Seq_THP-1_Human1.18167481
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.16503435
79ZNF263_19887448_ChIP-Seq_K562_Human1.15872292
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15737989
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15585751
82TCF7_22412390_ChIP-Seq_EML_Mouse1.15333052
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13501254
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.12322298
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10573962
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09590593
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09293605
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.08905148
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08545833
90* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07159049
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06814950
92RACK7_27058665_Chip-Seq_MCF-7_Human1.05410945
93AR_21572438_ChIP-Seq_LNCaP_Human1.04037414
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02478973
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01906888
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01811790
97* TP63_23658742_ChIP-Seq_EP156T_Human0.99777930
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99134242
99* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98887209
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98772918
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98235506
102KDM2B_26808549_Chip-Seq_DND41_Human0.96545491
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95881197
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95605262
105SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94562017
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94283960
107RUNX1_27514584_Chip-Seq_MCF-7_Human0.94160009
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94100372
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93485084
110EED_16625203_ChIP-ChIP_MESCs_Mouse0.92857929
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91963237
112PU_27001747_Chip-Seq_BMDM_Mouse0.91582977
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90625065
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89165878
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.88198368
116AHR_22903824_ChIP-Seq_MCF-7_Human0.88172288
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88031537
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.86213541
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.86213541
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.85868764
121KDM2B_26808549_Chip-Seq_K562_Human0.85627180
122GATA4_25053715_ChIP-Seq_YYC3_Human0.84758273
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84666017
124SPI1_23547873_ChIP-Seq_NB4_Human0.83753116
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.82397694
126* GATA3_24758297_ChIP-Seq_MCF-7_Human0.82054463
127SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.81815749
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80667083
129VDR_24787735_ChIP-Seq_THP-1_Human0.80569722
130RXR_22108803_ChIP-Seq_LS180_Human0.79979485
131TP53_23651856_ChIP-Seq_MEFs_Mouse0.78467239
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.75946841
133KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74207263
134KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73981170
135SA1_22415368_ChIP-Seq_MEFs_Mouse0.72079010
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.71864027
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71727675
138TP53_22127205_ChIP-Seq_IMR90_Human0.70220001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.85178666
2MP0004272_abnormal_basement_membrane3.53558266
3MP0009840_abnormal_foam_cell3.39317816
4MP0005623_abnormal_meninges_morphology3.26201367
5MP0005275_abnormal_skin_tensile3.25664628
6MP0003566_abnormal_cell_adhesion3.11263650
7MP0003705_abnormal_hypodermis_morpholog3.11237614
8MP0010352_gastrointestinal_tract_polyps2.98565801
9MP0003279_aneurysm2.96557136
10MP0003941_abnormal_skin_development2.87705018
11MP0005058_abnormal_lysosome_morphology2.73510557
12MP0001958_emphysema2.70320524
13MP0004510_myositis2.65777234
14MP0003436_decreased_susceptibility_to2.63862212
15MP0003191_abnormal_cellular_cholesterol2.57201673
16MP0010368_abnormal_lymphatic_system2.55520847
17MP0005503_abnormal_tendon_morphology2.53401219
18MP0005023_abnormal_wound_healing2.43714311
19MP0009379_abnormal_foot_pigmentation2.38677898
20MP0008004_abnormal_stomach_pH2.32140209
21MP0003091_abnormal_cell_migration2.31747136
22MP0003075_altered_response_to2.29488605
23MP0009384_cardiac_valve_regurgitation2.28244685
24MP0002148_abnormal_hypersensitivity_rea2.03977366
25MP0001879_abnormal_lymphatic_vessel2.01510201
26MP0003828_pulmonary_edema1.97701875
27MP0001542_abnormal_bone_strength1.96504568
28MP0006054_spinal_hemorrhage1.96162987
29MP0002419_abnormal_innate_immunity1.94171652
30MP0002332_abnormal_exercise_endurance1.93428128
31MP0004947_skin_inflammation1.92097033
32MP0002060_abnormal_skin_morphology1.88911656
33MP0002295_abnormal_pulmonary_circulatio1.85593963
34MP0009764_decreased_sensitivity_to1.84858248
35MP0000750_abnormal_muscle_regeneration1.80800849
36MP0006082_CNS_inflammation1.80603849
37MP0002877_abnormal_melanocyte_morpholog1.80588003
38MP0009278_abnormal_bone_marrow1.70223211
39MP0005166_decreased_susceptibility_to1.69269142
40MP0010234_abnormal_vibrissa_follicle1.66827484
41MP0009785_altered_susceptibility_to1.66733461
42MP0005508_abnormal_skeleton_morphology1.66097300
43MP0003724_increased_susceptibility_to1.64949876
44MP0003950_abnormal_plasma_membrane1.64177337
45MP0010030_abnormal_orbit_morphology1.59942992
46MP0009250_abnormal_appendicular_skeleto1.52287454
47MP0005164_abnormal_response_to1.50893718
48MP0002796_impaired_skin_barrier1.50648486
49MP0000762_abnormal_tongue_morphology1.47091104
50MP0004883_abnormal_blood_vessel1.46253253
51MP0004484_altered_response_of1.46227601
52MP0000767_abnormal_smooth_muscle1.45600871
53MP0005595_abnormal_vascular_smooth1.39866054
54MP0000383_abnormal_hair_follicle1.36637533
55MP0003453_abnormal_keratinocyte_physiol1.36016859
56MP0002282_abnormal_trachea_morphology1.35133658
57MP0000604_amyloidosis1.34845383
58MP0001851_eye_inflammation1.34673733
59MP0002896_abnormal_bone_mineralization1.32780792
60MP0005451_abnormal_body_composition1.32322976
61MP0005000_abnormal_immune_tolerance1.31987536
62MP0005084_abnormal_gallbladder_morpholo1.28780776
63MP0003385_abnormal_body_wall1.28532951
64MP0005257_abnormal_intraocular_pressure1.28397269
65MP0003172_abnormal_lysosome_physiology1.27518021
66MP0003806_abnormal_nucleotide_metabolis1.27265634
67MP0005025_abnormal_response_to1.27259519
68MP0005390_skeleton_phenotype1.25886439
69MP0005464_abnormal_platelet_physiology1.25604704
70MP0005165_increased_susceptibility_to1.21601406
71MP0000733_abnormal_muscle_development1.19653682
72MP0004084_abnormal_cardiac_muscle1.19464092
73MP0008260_abnormal_autophagy1.19217670
74MP0001853_heart_inflammation1.19014106
75MP0001243_abnormal_dermal_layer1.18994516
76MP0003045_fibrosis1.18238975
77MP0002452_abnormal_antigen_presenting1.18238669
78MP0009053_abnormal_anal_canal1.18041272
79MP0003448_altered_tumor_morphology1.16084520
80MP0010678_abnormal_skin_adnexa1.15384454
81MP0000013_abnormal_adipose_tissue1.12716686
82* MP0000163_abnormal_cartilage_morphology1.11544411
83MP0005501_abnormal_skin_physiology1.11243972
84MP0002933_joint_inflammation1.10878712
85MP0003656_abnormal_erythrocyte_physiolo1.10667279
86MP0001849_ear_inflammation1.10343364
87MP0000516_abnormal_urinary_system1.09988589
88MP0005367_renal/urinary_system_phenotyp1.09988589
89MP0002254_reproductive_system_inflammat1.09846901
90MP0001545_abnormal_hematopoietic_system1.09707394
91MP0005397_hematopoietic_system_phenotyp1.09707394
92MP0000465_gastrointestinal_hemorrhage1.09321237
93MP0000858_altered_metastatic_potential1.08841259
94MP0003303_peritoneal_inflammation1.08105055
95MP0004233_abnormal_muscle_weight1.07554979
96MP0000343_altered_response_to1.07338165
97MP0001533_abnormal_skeleton_physiology1.07180611
98MP0008775_abnormal_heart_ventricle1.05549831
99MP0000751_myopathy1.05479123
100MP0010771_integument_phenotype1.03827617
101MP0002925_abnormal_cardiovascular_devel1.03000192
102MP0003329_amyloid_beta_deposits1.02797524
103MP0000537_abnormal_urethra_morphology1.02532496
104MP0006138_congestive_heart_failure1.01801899
105MP0002405_respiratory_system_inflammati1.00640328
106MP0001790_abnormal_immune_system0.99895315
107MP0005387_immune_system_phenotype0.99895315
108MP0001845_abnormal_inflammatory_respons0.99869146
109MP0000249_abnormal_blood_vessel0.99645802
110MP0003755_abnormal_palate_morphology0.97961936
111* MP0001614_abnormal_blood_vessel0.97903050
112MP0001299_abnormal_eye_distance/0.97040574
113MP0002113_abnormal_skeleton_development0.96007048
114MP0003300_gastrointestinal_ulcer0.95821000
115MP0002723_abnormal_immune_serum0.95150946
116MP0008469_abnormal_protein_level0.94203147
117MP0000467_abnormal_esophagus_morphology0.93914316
118MP0005388_respiratory_system_phenotype0.93865985
119MP0002133_abnormal_respiratory_system0.93865985
120MP0002128_abnormal_blood_circulation0.91501483
121MP0002998_abnormal_bone_remodeling0.90355603
122MP0000627_abnormal_mammary_gland0.89961241
123MP0000747_muscle_weakness0.89744296
124* MP0001216_abnormal_epidermal_layer0.89209488
125MP0005167_abnormal_blood-brain_barrier0.86348092
126MP0005248_abnormal_Harderian_gland0.84713322
127* MP0002972_abnormal_cardiac_muscle0.84407890
128MP0002098_abnormal_vibrissa_morphology0.83802632
129MP0002115_abnormal_skeleton_extremities0.83441857
130MP0002108_abnormal_muscle_morphology0.83135947
131MP0003942_abnormal_urinary_system0.82315807
132MP0002420_abnormal_adaptive_immunity0.80252146
133MP0009780_abnormal_chondrocyte_physiolo0.80066047
134MP0003283_abnormal_digestive_organ0.79819592
135MP0001835_abnormal_antigen_presentation0.79590411
136MP0000432_abnormal_head_morphology0.78850030
137MP0001819_abnormal_immune_cell0.78478908
138MP0002089_abnormal_postnatal_growth/wei0.76759907
139MP0003795_abnormal_bone_structure0.72934143
140MP0004782_abnormal_surfactant_physiolog0.72758194
141MP0000049_abnormal_middle_ear0.72599501
142MP0000749_muscle_degeneration0.70762498
143MP0005076_abnormal_cell_differentiation0.67625099

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.18283282
2Abnormality of liposaccharide metabolism (HP:0010968)5.45111827
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.45111827
4Abnormality of glycolipid metabolism (HP:0010969)5.45111827
5Protrusio acetabuli (HP:0003179)5.26681037
6Atrophic scars (HP:0001075)5.21301153
7Amyloidosis (HP:0011034)4.13675609
8Axonal loss (HP:0003447)3.80328658
9Fragile skin (HP:0001030)3.68091919
10Shallow orbits (HP:0000586)3.60884542
11Aortic dissection (HP:0002647)3.51329517
12Interstitial pulmonary disease (HP:0006530)3.45340558
13Abnormality of macrophages (HP:0004311)3.40860983
14Myocardial infarction (HP:0001658)3.39843421
15Increased connective tissue (HP:0009025)3.38738072
16Aortic aneurysm (HP:0004942)3.28948067
17Neurofibrillary tangles (HP:0002185)3.27328611
18Dysostosis multiplex (HP:0000943)3.27053194
19Spinal rigidity (HP:0003306)3.26758921
20Increased cerebral lipofuscin (HP:0011813)3.24582962
21Distal lower limb muscle weakness (HP:0009053)3.23287425
22Vacuolated lymphocytes (HP:0001922)3.15633654
23Cervical subluxation (HP:0003308)3.14998282
24Neonatal short-limb short stature (HP:0008921)3.14648519
25Milia (HP:0001056)3.10011086
26Right ventricular cardiomyopathy (HP:0011663)3.07514230
27Short nail (HP:0001799)3.05914967
28Aplasia involving bones of the upper limbs (HP:0009823)2.93248181
29Aplasia of the phalanges of the hand (HP:0009802)2.93248181
30Aplasia involving bones of the extremities (HP:0009825)2.93248181
31Epiphyseal dysplasia (HP:0002656)2.93089276
32Onycholysis (HP:0001806)2.92303662
33Tetraparesis (HP:0002273)2.87206777
34Vascular tortuosity (HP:0004948)2.86038247
35Dilatation of the ascending aorta (HP:0005111)2.83665966
36Peritonitis (HP:0002586)2.82661121
37Asymmetric septal hypertrophy (HP:0001670)2.81182276
38Cerebral aneurysm (HP:0004944)2.79738561
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75848011
40Abnormality of polysaccharide metabolism (HP:0011012)2.75848011
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75848011
42Soft skin (HP:0000977)2.71295114
43Loss of speech (HP:0002371)2.70133034
44Distal lower limb amyotrophy (HP:0008944)2.66558898
45Difficulty climbing stairs (HP:0003551)2.63927750
46Urinary glycosaminoglycan excretion (HP:0003541)2.62771066
47Mucopolysacchariduria (HP:0008155)2.62771066
48Wormian bones (HP:0002645)2.62207365
49Abnormality of dentin (HP:0010299)2.59885749
50Spondylolisthesis (HP:0003302)2.59287259
51Muscle fiber splitting (HP:0003555)2.56330242
52Fragile nails (HP:0001808)2.55128930
53Bronchomalacia (HP:0002780)2.53346331
54Increased neuronal autofluorescent lipopigment (HP:0002074)2.48212286
55Abnormality of nail color (HP:0100643)2.47743637
56Cupped ribs (HP:0000887)2.47534258
57Round ear (HP:0100830)2.44308104
58Muscle fiber inclusion bodies (HP:0100299)2.40249693
59Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.38476678
60Recurrent bacterial skin infections (HP:0005406)2.37743358
61Cerebral inclusion bodies (HP:0100314)2.37549741
62Overgrowth (HP:0001548)2.32201278
63Nemaline bodies (HP:0003798)2.31916315
64Anhidrosis (HP:0000970)2.31562554
65Systemic lupus erythematosus (HP:0002725)2.29665429
66Abnormal vertebral ossification (HP:0100569)2.28778530
67Vertebral compression fractures (HP:0002953)2.27982970
68Neuronal loss in central nervous system (HP:0002529)2.23814074
69Flat acetabular roof (HP:0003180)2.22984345
70Increased density of long bones (HP:0006392)2.21395786
71Arterial tortuosity (HP:0005116)2.20400586
72Alopecia of scalp (HP:0002293)2.19879814
73Genu recurvatum (HP:0002816)2.18530280
74Mitral valve prolapse (HP:0001634)2.17794189
75Nuclear cataract (HP:0100018)2.16944626
76Vertebral hypoplasia (HP:0008417)2.16738080
77Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.16738080
78Mutism (HP:0002300)2.15890843
79Wrist flexion contracture (HP:0001239)2.15793229
80Broad face (HP:0000283)2.15539215
81Recurrent abscess formation (HP:0002722)2.14338107
82Coxa vara (HP:0002812)2.13814376
83Hypoplastic ischia (HP:0003175)2.12922204
84Blue sclerae (HP:0000592)2.12559043
85Reduced subcutaneous adipose tissue (HP:0003758)2.11008016
86Broad metatarsal (HP:0001783)2.10015415
87Abnormality of the 2nd finger (HP:0004100)2.09869751
88Mitral regurgitation (HP:0001653)2.08859989
89Mildly elevated creatine phosphokinase (HP:0008180)2.08113071
90Abnormal hemoglobin (HP:0011902)2.07451222
91Apathy (HP:0000741)2.05479429
92Bladder diverticulum (HP:0000015)2.04805201
93Spinal cord compression (HP:0002176)2.04492423
94Fused cervical vertebrae (HP:0002949)2.04333353
95Thin bony cortex (HP:0002753)2.04179235
96Hyporeflexia of lower limbs (HP:0002600)2.02840306
97Short hallux (HP:0010109)2.02702876
98Xerostomia (HP:0000217)2.02389710
99Elevated erythrocyte sedimentation rate (HP:0003565)2.00291990
100Diminished motivation (HP:0000745)1.99304092
101Elbow flexion contracture (HP:0002987)1.98404295
102Thick nail (HP:0001805)1.95704067
103Abnormality of the distal phalanges of the toes (HP:0010182)1.95422137
104Disinhibition (HP:0000734)1.94836088
105Tibial bowing (HP:0002982)1.94656516
106Lower limb amyotrophy (HP:0007210)1.94645080
107Scapular winging (HP:0003691)1.94034795
108EMG: myopathic abnormalities (HP:0003458)1.93587271
109Pterygium (HP:0001059)1.93376196
110Radial bowing (HP:0002986)1.92495576
111Centrally nucleated skeletal muscle fibers (HP:0003687)1.92479563
112Upper motor neuron abnormality (HP:0002127)1.92056467
113Eczematoid dermatitis (HP:0000976)1.91304275
114Ankle contracture (HP:0006466)1.91240777
115Joint stiffness (HP:0001387)1.89777527
116Vitreoretinal degeneration (HP:0000655)1.88435324
117Abnormality of the proximal phalanges of the hand (HP:0009834)1.87692714
118Abnormality of the calcaneus (HP:0008364)1.87436388
119Achilles tendon contracture (HP:0001771)1.86505373
120Polygenic inheritance (HP:0010982)1.86291666
121Upper limb muscle weakness (HP:0003484)1.86161661
122Segmental peripheral demyelination/remyelination (HP:0003481)1.85427659
123Down-sloping shoulders (HP:0200021)1.84927234
124Natal tooth (HP:0000695)1.84736195
125Abnormality of the nasal septum (HP:0000419)1.82944622
126Supranuclear gaze palsy (HP:0000605)1.82236737
127Hematochezia (HP:0002573)1.80925217
128Ectopia lentis (HP:0001083)1.80855569
129Acanthosis nigricans (HP:0000956)1.80524690
130Glossoptosis (HP:0000162)1.80338435
131Congenital, generalized hypertrichosis (HP:0004540)1.78932410
132Follicular hyperkeratosis (HP:0007502)1.78644159
133Exercise-induced myalgia (HP:0003738)1.78592687
134Abnormality of the acetabulum (HP:0003170)1.78392653
135Vascular calcification (HP:0004934)1.77498902
136Plantar hyperkeratosis (HP:0007556)1.77474874
137Cardiovascular calcification (HP:0011915)1.77137770
138Stomatitis (HP:0010280)1.77042542
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76964361
140Hyperextensible skin (HP:0000974)1.76909361
141Abnormal blistering of the skin (HP:0008066)1.76873347
142Aplasia/Hypoplasia of the hallux (HP:0008362)1.76653134
143Recurrent gram-negative bacterial infections (HP:0005420)1.76184236
144Abnormality of the ischium (HP:0003174)1.76051322
145Mediastinal lymphadenopathy (HP:0100721)1.75697026
146Bone cyst (HP:0012062)1.75187167
147Abnormality of the umbilical cord (HP:0010881)1.74729964
148Limb-girdle muscle atrophy (HP:0003797)1.74282760
149Trismus (HP:0000211)1.73733991
150Increased serum ferritin (HP:0003281)1.72996362
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.71328034
152Osteolytic defects of the hand bones (HP:0009699)1.71328034
153Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71259020
154Camptodactyly of toe (HP:0001836)1.71256890
155Malnutrition (HP:0004395)1.71247683
156Mesangial abnormality (HP:0001966)1.71049876
157Distal upper limb amyotrophy (HP:0007149)1.70700121
158Upper limb amyotrophy (HP:0009129)1.70700121
159Coronal craniosynostosis (HP:0004440)1.70442324
160Stillbirth (HP:0003826)1.70303954
161Aneurysm (HP:0002617)1.70269326
162Increased CSF protein (HP:0002922)1.70162853
163Nail dystrophy (HP:0008404)1.69981991
164Autoimmune thrombocytopenia (HP:0001973)1.69908215
165Ileus (HP:0002595)1.69678413
166Aortic valve stenosis (HP:0001650)1.69140004
167Palmoplantar hyperkeratosis (HP:0000972)1.67350903
168Fatigue (HP:0012378)1.66593500
169Progressive neurologic deterioration (HP:0002344)1.61844526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.23033459
2MAP3K33.92516550
3PIM22.75402697
4BLK2.74796185
5EPHB22.59885640
6TIE12.51809934
7MST42.51504090
8DDR22.39439120
9TTN2.38097713
10ARAF2.33095993
11TESK12.23403035
12FER2.11178439
13TRPM72.05571597
14PAK21.99614098
15RIPK11.97312388
16PRPF4B1.93441906
17LATS21.92680412
18LIMK11.87039603
19TGFBR21.81997817
20MAPK151.77081533
21LATS11.70543477
22TAOK11.67828687
23PRKG21.66461137
24MAP2K21.60899853
25PIK3CG1.58490682
26MAP3K131.58331974
27ERBB31.57550163
28MAP3K111.54935897
29PTK21.53661970
30MYLK1.52013644
31PIK3CA1.48413336
32STK101.46765707
33MOS1.44069683
34TAOK21.43419754
35DMPK1.41139691
36LRRK21.38119269
37MST1R1.37756056
38ERN11.37240602
39ZAP701.32323314
40TESK21.27650215
41PDGFRA1.25378375
42BMX1.24209879
43MAP3K91.22980025
44STK38L1.22756468
45STK241.22320849
46MAP2K31.21125990
47TRIB31.18929005
48MET1.16570638
49KDR1.16101023
50PAK31.11741305
51MAPK71.11351082
52RPS6KB21.07830094
53NUAK11.06219399
54BMPR21.03462589
55PTK2B1.03141957
56MAP3K11.00937426
57PTK60.98761602
58MAPK120.97725337
59MAPKAPK30.95188866
60OBSCN0.92180125
61MAP3K120.91596809
62TGFBR10.90116885
63NME20.89808074
64MAP2K10.88085265
65RPS6KA40.87703831
66ERBB40.87532584
67ROCK10.86775865
68FRK0.81817494
69EPHB10.80180835
70IRAK20.79896434
71CAMK1D0.76716160
72PDGFRB0.76014613
73GSK3A0.73879233
74FGR0.73338467
75EPHA30.72493402
76PAK40.72344312
77ILK0.71237322
78IRAK40.70675669
79RPS6KA20.67367176
80DAPK30.66618079
81PBK0.63856789
82STK30.63794680
83TYK20.63591891
84IKBKE0.62654820
85INSR0.62396745
86SIK10.62323438
87PDPK10.62142717
88LMTK20.62083953
89SIK30.61116783
90MAPKAPK50.61095697
91NTRK10.59075963
92GRK70.57949370
93PDK20.55628123
94GRK10.55470642
95TEC0.55390165
96RIPK40.54562317
97IRAK10.52312910
98RPS6KC10.50989882
99RPS6KL10.50989882
100MAP3K60.50433849
101NEK90.49992253
102NME10.49988347
103MAPK40.49768527
104MAPKAPK20.49662350
105IKBKB0.48196954
106ADRBK10.47670049
107MAP3K140.47333771
108TBK10.47225840
109PRKD10.46761195
110PKN20.44126382
111EGFR0.43621839
112ABL20.43092714
113MAP3K50.42840274
114PRKCE0.42819502
115CAMKK20.42698378
116FGFR10.42063904
117IRAK30.40588769
118MAP3K80.40122839
119MAP3K20.39779708
120PHKG10.38753042
121PHKG20.38753042
122MATK0.38007672
123CSK0.37921058
124ROCK20.37819465
125RPS6KA60.36712520
126ABL10.36267183
127NLK0.36085956
128CDC42BPA0.36084538
129KSR10.35237865
130CHUK0.34003228
131ZAK0.33976870
132PAK10.33689033
133PRKD20.33413869
134IGF1R0.33399873
135HIPK20.33218443
136BCR0.33078042
137EIF2AK20.32127118
138SRC0.31281581
139CAMK2G0.31063152
140MTOR0.30946390
141SGK30.30849909

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.07129901
2Other glycan degradation_Homo sapiens_hsa005112.98451408
3Focal adhesion_Homo sapiens_hsa045102.73715323
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.57834297
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.53324660
6Lysosome_Homo sapiens_hsa041422.44389908
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.37670060
8Adherens junction_Homo sapiens_hsa045202.28320438
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.27948432
10* Proteoglycans in cancer_Homo sapiens_hsa052052.18773356
11Dilated cardiomyopathy_Homo sapiens_hsa054142.12884225
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.09611517
13Malaria_Homo sapiens_hsa051442.06890416
14Hippo signaling pathway_Homo sapiens_hsa043902.06632586
15Small cell lung cancer_Homo sapiens_hsa052222.04382917
16TGF-beta signaling pathway_Homo sapiens_hsa043502.00994423
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.99321556
18* Bladder cancer_Homo sapiens_hsa052191.96632063
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.95527580
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.88932917
21Amoebiasis_Homo sapiens_hsa051461.88495964
22Tight junction_Homo sapiens_hsa045301.84558333
23Protein digestion and absorption_Homo sapiens_hsa049741.77410026
24Tuberculosis_Homo sapiens_hsa051521.67191860
25MicroRNAs in cancer_Homo sapiens_hsa052061.66324216
26TNF signaling pathway_Homo sapiens_hsa046681.66016851
27Prion diseases_Homo sapiens_hsa050201.49177417
28Staphylococcus aureus infection_Homo sapiens_hsa051501.48012461
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.46403721
30Shigellosis_Homo sapiens_hsa051311.44887100
31p53 signaling pathway_Homo sapiens_hsa041151.40810181
32Regulation of actin cytoskeleton_Homo sapiens_hsa048101.39344418
33Basal cell carcinoma_Homo sapiens_hsa052171.38071734
34Rap1 signaling pathway_Homo sapiens_hsa040151.35846473
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26870316
36Ribosome_Homo sapiens_hsa030101.25268256
37Salmonella infection_Homo sapiens_hsa051321.22807407
38Influenza A_Homo sapiens_hsa051641.22708024
39Viral myocarditis_Homo sapiens_hsa054161.21878298
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21347183
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19000079
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17412655
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16017065
44Galactose metabolism_Homo sapiens_hsa000521.11647767
45Complement and coagulation cascades_Homo sapiens_hsa046101.11015053
46Hematopoietic cell lineage_Homo sapiens_hsa046401.10815334
47Toxoplasmosis_Homo sapiens_hsa051451.09105591
48Pathways in cancer_Homo sapiens_hsa052001.04876764
49HIF-1 signaling pathway_Homo sapiens_hsa040661.04576189
50Apoptosis_Homo sapiens_hsa042101.04275489
51Hedgehog signaling pathway_Homo sapiens_hsa043401.04195141
52Platelet activation_Homo sapiens_hsa046111.02452256
53HTLV-I infection_Homo sapiens_hsa051661.02092550
54Melanoma_Homo sapiens_hsa052181.01786488
55Sphingolipid metabolism_Homo sapiens_hsa006000.99725451
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96552574
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95638862
58Axon guidance_Homo sapiens_hsa043600.95361692
59Leishmaniasis_Homo sapiens_hsa051400.94659403
60Rheumatoid arthritis_Homo sapiens_hsa053230.93844514
61Chronic myeloid leukemia_Homo sapiens_hsa052200.92553572
62Pertussis_Homo sapiens_hsa051330.91686321
63Mineral absorption_Homo sapiens_hsa049780.90893615
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87627348
65Wnt signaling pathway_Homo sapiens_hsa043100.86785491
66Melanogenesis_Homo sapiens_hsa049160.84535311
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.81352648
68Dorso-ventral axis formation_Homo sapiens_hsa043200.80814542
69Renal cell carcinoma_Homo sapiens_hsa052110.80339327
70Phagosome_Homo sapiens_hsa041450.79276882
71VEGF signaling pathway_Homo sapiens_hsa043700.79007813
72Ras signaling pathway_Homo sapiens_hsa040140.78851347
73Arachidonic acid metabolism_Homo sapiens_hsa005900.75771220
74Prostate cancer_Homo sapiens_hsa052150.73246194
75Chemokine signaling pathway_Homo sapiens_hsa040620.73089661
76Osteoclast differentiation_Homo sapiens_hsa043800.73017996
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70635664
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69565256
79Gap junction_Homo sapiens_hsa045400.69355604
80Asthma_Homo sapiens_hsa053100.68801472
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68243946
82B cell receptor signaling pathway_Homo sapiens_hsa046620.67343805
83Sulfur metabolism_Homo sapiens_hsa009200.66627700
84MAPK signaling pathway_Homo sapiens_hsa040100.66181604
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64649463
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64175795
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63820303
88Acute myeloid leukemia_Homo sapiens_hsa052210.61627339
89Thyroid cancer_Homo sapiens_hsa052160.61273970
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.60834925
91Fructose and mannose metabolism_Homo sapiens_hsa000510.60722559
92Hepatitis C_Homo sapiens_hsa051600.60419069
93Circadian rhythm_Homo sapiens_hsa047100.58436218
94Notch signaling pathway_Homo sapiens_hsa043300.57096978
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.54966428
96Hepatitis B_Homo sapiens_hsa051610.54796854
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.53851040
98Measles_Homo sapiens_hsa051620.53557139
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53076249
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.52955495
101Pentose phosphate pathway_Homo sapiens_hsa000300.52828083
102Insulin resistance_Homo sapiens_hsa049310.52331131
103Vibrio cholerae infection_Homo sapiens_hsa051100.51952975
104Graft-versus-host disease_Homo sapiens_hsa053320.51276008
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50758476
106FoxO signaling pathway_Homo sapiens_hsa040680.49821345
107Pancreatic cancer_Homo sapiens_hsa052120.48654363
108Thyroid hormone synthesis_Homo sapiens_hsa049180.48269309
109Antigen processing and presentation_Homo sapiens_hsa046120.47282713
110* GnRH signaling pathway_Homo sapiens_hsa049120.47214486
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.47167191
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46929113
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46779614
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.46546993
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.46268673
116Viral carcinogenesis_Homo sapiens_hsa052030.46167617
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46155606
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45071704
119Herpes simplex infection_Homo sapiens_hsa051680.44633224
120Cocaine addiction_Homo sapiens_hsa050300.44530793
121Endocytosis_Homo sapiens_hsa041440.43616973
122African trypanosomiasis_Homo sapiens_hsa051430.42337323
123Legionellosis_Homo sapiens_hsa051340.41456185
124Ovarian steroidogenesis_Homo sapiens_hsa049130.41256487
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.40915383
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40836047
127* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40615613
128Protein export_Homo sapiens_hsa030600.40396781
129Glioma_Homo sapiens_hsa052140.39519486
130* ErbB signaling pathway_Homo sapiens_hsa040120.39062827
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38435471
132Endometrial cancer_Homo sapiens_hsa052130.37947233
133Colorectal cancer_Homo sapiens_hsa052100.37219981
134* Estrogen signaling pathway_Homo sapiens_hsa049150.35260102
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35012303
136Prolactin signaling pathway_Homo sapiens_hsa049170.34905879

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