HBBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)9.85367801
2gas transport (GO:0015669)9.66456288
3porphyrin-containing compound biosynthetic process (GO:0006779)8.38986095
4erythrocyte maturation (GO:0043249)7.90291047
5tetrapyrrole biosynthetic process (GO:0033014)7.47478728
6erythrocyte development (GO:0048821)7.14623709
7porphyrin-containing compound metabolic process (GO:0006778)6.99451840
8heme biosynthetic process (GO:0006783)6.71888136
9heme metabolic process (GO:0042168)5.53790135
10negative regulation of erythrocyte differentiation (GO:0045647)5.34160377
11iron ion import (GO:0097286)5.14869285
12hemoglobin metabolic process (GO:0020027)5.02613123
13DNA topological change (GO:0006265)4.98734660
14nuclear pore complex assembly (GO:0051292)4.95493252
15definitive hemopoiesis (GO:0060216)4.89714657
16myeloid cell development (GO:0061515)4.88951860
17granulocyte differentiation (GO:0030851)4.82439872
18regulation of RNA export from nucleus (GO:0046831)4.61240813
19DNA replication checkpoint (GO:0000076)4.41196702
20tetrapyrrole metabolic process (GO:0033013)4.34005716
21nuclear pore organization (GO:0006999)4.29605712
22regulation of response to osmotic stress (GO:0047484)4.26421972
23DNA replication initiation (GO:0006270)3.96592344
24regulation of histone H3-K4 methylation (GO:0051569)3.95426707
25DNA unwinding involved in DNA replication (GO:0006268)3.93176526
26one-carbon compound transport (GO:0019755)3.88264358
27platelet formation (GO:0030220)3.78127695
28regulation of translational fidelity (GO:0006450)3.77036728
29regulation of nucleobase-containing compound transport (GO:0032239)3.75065506
30mitotic chromosome condensation (GO:0007076)3.74451920
31mitotic sister chromatid segregation (GO:0000070)3.72796205
32pore complex assembly (GO:0046931)3.68758227
33regulation of histone H3-K9 methylation (GO:0051570)3.62745016
34regulation of erythrocyte differentiation (GO:0045646)3.61961484
35proline biosynthetic process (GO:0006561)3.60628197
36sister chromatid segregation (GO:0000819)3.58111811
37mitotic nuclear envelope disassembly (GO:0007077)3.57843345
38megakaryocyte development (GO:0035855)3.55867846
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53740611
40positive regulation of megakaryocyte differentiation (GO:0045654)3.53636380
41meiotic chromosome segregation (GO:0045132)3.50669516
42response to methylmercury (GO:0051597)3.50464332
43erythrocyte differentiation (GO:0030218)3.41360712
44DNA strand elongation involved in DNA replication (GO:0006271)3.41248552
45membrane disassembly (GO:0030397)3.40538873
46nuclear envelope disassembly (GO:0051081)3.40538873
47hematopoietic stem cell differentiation (GO:0060218)3.36902744
48pigment biosynthetic process (GO:0046148)3.34880954
49DNA strand elongation (GO:0022616)3.34737937
50embryonic hemopoiesis (GO:0035162)3.29814126
51synapsis (GO:0007129)3.26115982
52regulation of histone H3-K27 methylation (GO:0061085)3.23226861
53positive regulation of erythrocyte differentiation (GO:0045648)3.19904472
54negative regulation of histone methylation (GO:0031061)3.19720296
55diterpenoid biosynthetic process (GO:0016102)3.18085637
56negative regulation of fatty acid biosynthetic process (GO:0045717)3.13895251
57response to lead ion (GO:0010288)3.13044044
58homocysteine metabolic process (GO:0050667)3.11312832
59positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.10954080
60telomere maintenance via semi-conservative replication (GO:0032201)3.07252745
61response to insecticide (GO:0017085)3.06368070
62cellular response to thyroid hormone stimulus (GO:0097067)3.05852856
63formation of translation preinitiation complex (GO:0001731)3.04202804
64chromosome segregation (GO:0007059)3.01911841
65protein-cofactor linkage (GO:0018065)3.00963924
66resolution of meiotic recombination intermediates (GO:0000712)3.00743480
67microtubule depolymerization (GO:0007019)2.98015982
68kinetochore organization (GO:0051383)2.96599287
69regulation of histone methylation (GO:0031060)2.94625476
70negative regulation of potassium ion transmembrane transport (GO:1901380)2.92103395
71terpenoid biosynthetic process (GO:0016114)2.90636785
72positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.90166959
73positive regulation of histone methylation (GO:0031062)2.88165537
74potassium ion export (GO:0071435)2.86016455
75folic acid-containing compound biosynthetic process (GO:0009396)2.84987584
76response to thyroid hormone (GO:0097066)2.81679295
77pigment metabolic process (GO:0042440)2.80760630
78regulation of centriole replication (GO:0046599)2.77391452
79protein export from nucleus (GO:0006611)2.72182474
80positive regulation of granulocyte differentiation (GO:0030854)2.72135923
81telomere maintenance via recombination (GO:0000722)2.68165575
82glycine transport (GO:0015816)2.67700155
83protein localization to chromosome, centromeric region (GO:0071459)2.67299701
84tRNA aminoacylation for protein translation (GO:0006418)2.65082807
85deoxyribose phosphate biosynthetic process (GO:0046385)2.62458367
862-deoxyribonucleotide biosynthetic process (GO:0009265)2.62458367
87purine nucleobase biosynthetic process (GO:0009113)2.61590720
88mitotic recombination (GO:0006312)2.60429530
89deoxyribonucleotide biosynthetic process (GO:0009263)2.58886060
90response to arsenic-containing substance (GO:0046685)2.58562585
91regulation of mitotic spindle organization (GO:0060236)2.57222776
92very-low-density lipoprotein particle assembly (GO:0034379)2.57146904
93oxidative phosphorylation (GO:0006119)2.56572604
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56559716
95DNA synthesis involved in DNA repair (GO:0000731)2.56144968
96tetrahydrofolate metabolic process (GO:0046653)2.55944159
97tRNA aminoacylation (GO:0043039)2.55246554
98amino acid activation (GO:0043038)2.55246554
99protoporphyrinogen IX metabolic process (GO:0046501)12.0444528
100protoporphyrinogen IX biosynthetic process (GO:0006782)10.1534783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.33883186
2GATA1_22025678_ChIP-Seq_K562_Human5.76330889
3GATA1_19941826_ChIP-Seq_K562_Human4.47019173
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.14052309
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.03780142
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.28808489
7GATA2_19941826_ChIP-Seq_K562_Human2.92872815
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.80394562
9NCOR1_26117541_ChIP-Seq_K562_Human2.75913970
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67436508
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56145710
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53624375
13SCL_19346495_ChIP-Seq_HPC-7_Human2.53196120
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.45553309
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.14353576
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07015558
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04681551
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02194018
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.01397135
20TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.99324989
21XRN2_22483619_ChIP-Seq_HELA_Human1.86280204
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83612760
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83214306
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79504142
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75782309
26DCP1A_22483619_ChIP-Seq_HELA_Human1.73516423
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69317657
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65101153
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64732291
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.62257625
31GATA1_22383799_ChIP-Seq_G1ME_Mouse1.60875301
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59708624
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.59270995
34ZNF263_19887448_ChIP-Seq_K562_Human1.58072851
35MYC_22102868_ChIP-Seq_BL_Human1.57380923
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54785135
37FOXP3_21729870_ChIP-Seq_TREG_Human1.53551763
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52564460
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.49860957
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49300025
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.48291371
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47034368
43KDM5A_27292631_Chip-Seq_BREAST_Human1.45712265
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43868176
45TTF2_22483619_ChIP-Seq_HELA_Human1.42375158
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39730020
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38473684
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36751861
49VDR_23849224_ChIP-Seq_CD4+_Human1.35381362
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33079296
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32646865
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31504152
53SPI1_23127762_ChIP-Seq_K562_Human1.29359371
54CIITA_25753668_ChIP-Seq_RAJI_Human1.28097897
55TFEB_21752829_ChIP-Seq_HELA_Human1.27394966
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27306379
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24481831
58AR_21909140_ChIP-Seq_LNCAP_Human1.23777022
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23488251
60KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23081253
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21527120
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19826193
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18287478
64ELK1_19687146_ChIP-ChIP_HELA_Human1.17857540
65GABP_19822575_ChIP-Seq_HepG2_Human1.17434003
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16153151
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08188253
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07988014
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06748815
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04835693
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04793911
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03540738
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01036916
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00844212
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00359381
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00201924
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99048681
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97722253
79MAF_26560356_Chip-Seq_TH1_Human0.96918174
80KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96211116
81GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95869166
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95538474
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93787132
84YY1_21170310_ChIP-Seq_MESCs_Mouse0.92090106
85ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90807767
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90481944
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90168587
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87445221
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.87313509
90CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86030837
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85594972
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84856966
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83848491
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83836300
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82881500
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.82683105
97CHD1_26751641_Chip-Seq_LNCaP_Human0.82513296
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82104289
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.82093027
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80519696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level9.97731435
2MP0003656_abnormal_erythrocyte_physiolo7.60364640
3MP0005083_abnormal_biliary_tract5.05489320
4MP0008995_early_reproductive_senescence3.73731717
5MP0001545_abnormal_hematopoietic_system3.25069635
6MP0005397_hematopoietic_system_phenotyp3.25069635
7MP0003111_abnormal_nucleus_morphology3.18583471
8MP0004957_abnormal_blastocyst_morpholog2.66677917
9MP0008058_abnormal_DNA_repair2.53312217
10MP0010094_abnormal_chromosome_stability2.50956628
11MP0009697_abnormal_copulation2.44676116
12MP0003786_premature_aging2.19650569
13MP0008057_abnormal_DNA_replication2.18939374
14MP0005451_abnormal_body_composition1.98290468
15MP0003693_abnormal_embryo_hatching1.95076119
16MP0005464_abnormal_platelet_physiology1.86582664
17MP0003077_abnormal_cell_cycle1.82494986
18MP0006036_abnormal_mitochondrial_physio1.79383037
19MP0005636_abnormal_mineral_homeostasis1.78412271
20MP0002132_abnormal_respiratory_system1.74927253
21MP0009278_abnormal_bone_marrow1.67994582
22MP0003186_abnormal_redox_activity1.67820222
23MP0010307_abnormal_tumor_latency1.48739188
24MP0001529_abnormal_vocalization1.47331101
25MP0006035_abnormal_mitochondrial_morpho1.44850879
26MP0008932_abnormal_embryonic_tissue1.44623689
27MP0002396_abnormal_hematopoietic_system1.42127778
28MP0004145_abnormal_muscle_electrophysio1.37212996
29MP0001730_embryonic_growth_arrest1.31789038
30MP0008775_abnormal_heart_ventricle1.29290316
31MP0000313_abnormal_cell_death1.28588689
32MP0001661_extended_life_span1.22273766
33MP0004808_abnormal_hematopoietic_stem1.20836100
34MP0000678_abnormal_parathyroid_gland1.18639277
35MP0001697_abnormal_embryo_size1.16264033
36MP0008007_abnormal_cellular_replicative1.13264900
37MP0003718_maternal_effect1.12044450
38MP0000350_abnormal_cell_proliferation1.10589091
39MP0002080_prenatal_lethality1.09432718
40MP0002398_abnormal_bone_marrow1.03701852
41MP0002722_abnormal_immune_system1.02871650
42MP0002877_abnormal_melanocyte_morpholog1.02489493
43MP0009931_abnormal_skin_appearance0.99978846
44MP0002095_abnormal_skin_pigmentation0.99767707
45MP0000372_irregular_coat_pigmentation0.97914220
46MP0002086_abnormal_extraembryonic_tissu0.96650720
47MP0005380_embryogenesis_phenotype0.95290732
48MP0001672_abnormal_embryogenesis/_devel0.95290732
49MP0003984_embryonic_growth_retardation0.92504243
50MP0000703_abnormal_thymus_morphology0.88198024
51MP0000609_abnormal_liver_physiology0.88170657
52MP0001929_abnormal_gametogenesis0.88023958
53MP0000689_abnormal_spleen_morphology0.87874937
54MP0000358_abnormal_cell_content/0.87686261
55MP0002088_abnormal_embryonic_growth/wei0.87663533
56MP0002019_abnormal_tumor_incidence0.84293471
57MP0002210_abnormal_sex_determination0.80928723
58MP0005076_abnormal_cell_differentiation0.75407829
59MP0003806_abnormal_nucleotide_metabolis0.73893160
60MP0005171_absent_coat_pigmentation0.72541559
61MP0002429_abnormal_blood_cell0.71873494
62MP0008770_decreased_survivor_rate0.70853538
63MP0009333_abnormal_splenocyte_physiolog0.70209697
64MP0001727_abnormal_embryo_implantation0.69953911
65MP0008260_abnormal_autophagy0.69661228
66MP0000598_abnormal_liver_morphology0.69406468
67MP0004233_abnormal_muscle_weight0.68142970
68MP0003221_abnormal_cardiomyocyte_apopto0.67068856
69MP0003698_abnormal_male_reproductive0.66087050
70MP0003959_abnormal_lean_body0.65246219
71MP0001873_stomach_inflammation0.65223706
72MP0003303_peritoneal_inflammation0.65131965
73MP0000015_abnormal_ear_pigmentation0.63240581
74MP0003699_abnormal_female_reproductive0.61215929
75MP0005501_abnormal_skin_physiology0.59855199
76MP0005377_hearing/vestibular/ear_phenot0.58361612
77MP0003878_abnormal_ear_physiology0.58361612
78MP0009765_abnormal_xenobiotic_induced0.58291177
79MP0000653_abnormal_sex_gland0.56025566
80MP0005646_abnormal_pituitary_gland0.55318587
81MP0000343_altered_response_to0.54691955
82MP0001145_abnormal_male_reproductive0.53896288
83MP0004885_abnormal_endolymph0.52697002
84MP0005384_cellular_phenotype0.52624283
85MP0001764_abnormal_homeostasis0.52521344
86MP0008872_abnormal_physiological_respon0.51288706
87MP0002084_abnormal_developmental_patter0.51139956
88MP0001881_abnormal_mammary_gland0.49383917
89MP0002161_abnormal_fertility/fecundity0.48605824
90MP0002085_abnormal_embryonic_tissue0.48173688
91MP0000747_muscle_weakness0.48054132
92MP0003879_abnormal_hair_cell0.46521809
93MP0005621_abnormal_cell_physiology0.46501519
94MP0009703_decreased_birth_body0.45592167
95MP0005410_abnormal_fertilization0.45034520
96MP0001191_abnormal_skin_condition0.41808136
97MP0005647_abnormal_sex_gland0.41264988
98MP0001784_abnormal_fluid_regulation0.41024785
99MP0009763_increased_sensitivity_to0.40563390
100MP0005332_abnormal_amino_acid0.40466148

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)9.02109039
2Reticulocytosis (HP:0001923)8.65693274
3Abnormal gallbladder physiology (HP:0012438)7.02668794
4Cholecystitis (HP:0001082)7.02668794
5Abnormal hemoglobin (HP:0011902)6.66044755
6Abnormality of reticulocytes (HP:0004312)6.34566571
7Polycythemia (HP:0001901)5.66377468
8Acanthocytosis (HP:0001927)5.61199765
9Cholelithiasis (HP:0001081)5.51210977
10Abnormal gallbladder morphology (HP:0012437)4.96862084
11Ileus (HP:0002595)4.84303598
12Hyperbilirubinemia (HP:0002904)4.52482492
13Paralysis (HP:0003470)4.49814777
14Truncus arteriosus (HP:0001660)4.30041241
15Hyperthyroidism (HP:0000836)3.97479323
16Abnormality of the gallbladder (HP:0005264)3.84085550
17Microcytic anemia (HP:0001935)3.79186497
18Pallor (HP:0000980)3.70183804
19Hypertensive crisis (HP:0100735)3.70140877
20Prolonged bleeding time (HP:0003010)3.22989678
21Diaphragmatic weakness (HP:0009113)3.14713277
22Birth length less than 3rd percentile (HP:0003561)3.08499718
23Abnormal large intestine physiology (HP:0012700)2.96064594
24Abnormal number of erythroid precursors (HP:0012131)2.95328578
25Hypochromic microcytic anemia (HP:0004840)2.94590291
26Bowel incontinence (HP:0002607)2.92341442
27Seborrheic dermatitis (HP:0001051)2.90028370
28Abnormality of homocysteine metabolism (HP:0010919)2.89543759
29Homocystinuria (HP:0002156)2.89543759
30Abnormality of cells of the erythroid lineage (HP:0012130)2.74379771
31Nonimmune hydrops fetalis (HP:0001790)2.71461739
32Insomnia (HP:0100785)2.70595999
33Hypoparathyroidism (HP:0000829)2.69382063
34Nausea (HP:0002018)2.56397004
35Chromsome breakage (HP:0040012)2.50310791
36Impaired platelet aggregation (HP:0003540)2.43150398
37Abnormal platelet function (HP:0011869)2.43150398
38Petechiae (HP:0000967)2.41093969
39Ankyloglossia (HP:0010296)2.40965826
40Aplasia/Hypoplasia of the earlobes (HP:0009906)2.39182858
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38915274
42Acute myeloid leukemia (HP:0004808)2.32422430
43Short middle phalanx of the 5th finger (HP:0004220)2.25871263
44Abnormality of the tricuspid valve (HP:0001702)2.22874431
45Hepatocellular carcinoma (HP:0001402)2.22202417
46Upper limb muscle weakness (HP:0003484)2.22025980
47Abnormality of cochlea (HP:0000375)2.19114682
48Orthostatic hypotension (HP:0001278)2.17596848
49Cutaneous photosensitivity (HP:0000992)2.09907823
50Abnormality of iron homeostasis (HP:0011031)2.09296996
51Atelectasis (HP:0100750)2.05501800
52Abnormality of the fingertips (HP:0001211)2.04620173
53Gastrointestinal dysmotility (HP:0002579)2.03634938
54Abnormality of transition element cation homeostasis (HP:0011030)2.03312497
55Peripheral hypomyelination (HP:0007182)2.00731613
56Increased serum pyruvate (HP:0003542)2.00522577
57Abnormality of glycolysis (HP:0004366)2.00346892
58Abnormality of the heme biosynthetic pathway (HP:0010472)11.8285616
59Increased serum ferritin (HP:0003281)1.99339495
60Myelodysplasia (HP:0002863)1.93052297
61Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88819383
62Duplicated collecting system (HP:0000081)1.86921657
63Hypochromic anemia (HP:0001931)1.86699335
64Tinnitus (HP:0000360)1.86266366
65Increased mean platelet volume (HP:0011877)1.86061019
66Ventricular fibrillation (HP:0001663)1.79080900
67Breech presentation (HP:0001623)1.77204380
68Neoplasm of head and neck (HP:0012288)1.75816522
69Esophageal neoplasm (HP:0100751)1.75816522
70Abnormality of sulfur amino acid metabolism (HP:0004339)1.71229280
71Abnormality of nail color (HP:0100643)1.71185349
72Cortical dysplasia (HP:0002539)1.70884436
73Abnormal platelet volume (HP:0011876)1.68713097
74Epistaxis (HP:0000421)1.66650825
75Acute encephalopathy (HP:0006846)1.63426806
76Osteomalacia (HP:0002749)1.61256572
77Cerebral palsy (HP:0100021)1.61182734
78Long clavicles (HP:0000890)1.57319323
79Abnormality of oral frenula (HP:0000190)1.56923477
80Breast hypoplasia (HP:0003187)1.56527257
81Septate vagina (HP:0001153)1.56503711
82Hyponatremia (HP:0002902)1.55838638
83Abnormally folded helix (HP:0008544)1.55249448
84Aplasia/Hypoplasia of the thymus (HP:0010515)1.54737341
85Abnormality of the renal collecting system (HP:0004742)1.53898830
86Morphological abnormality of the inner ear (HP:0011390)1.53421570
87Small intestinal stenosis (HP:0012848)1.52736347
88Duodenal stenosis (HP:0100867)1.52736347
89Autoamputation (HP:0001218)1.52249663
90Sandal gap (HP:0001852)1.52103711
91Overlapping toe (HP:0001845)1.51538493
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.51183511
93Onycholysis (HP:0001806)1.50328835
94Pancreatic islet-cell hyperplasia (HP:0004510)1.47566402
95Reticulocytopenia (HP:0001896)1.46632421
96Abnormality of the preputium (HP:0100587)1.46148451
97Aplastic anemia (HP:0001915)1.41925199
98Abnormal mitochondria in muscle tissue (HP:0008316)1.41589102
99Venous insufficiency (HP:0005293)1.40884549
100Obstructive lung disease (HP:0006536)1.39824943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK17.75595064
2RIPK43.56992775
3CLK13.46825204
4PLK42.62836243
5TTK2.57953466
6BMX2.51750533
7KSR22.47065019
8PRPF4B2.35039532
9MST42.17232536
10CDC72.09984914
11STK42.04258611
12SCYL21.97930763
13BMPR21.90049626
14CCNB11.89833038
15RAF11.88869892
16BRSK21.80631317
17WEE11.74814581
18TAOK21.61375485
19MAP3K81.60743581
20PIM11.58984828
21EEF2K1.55656031
22MAP3K21.54852900
23NTRK31.48729588
24KSR11.46391246
25CHEK21.38731431
26DYRK31.38621458
27NME11.38568113
28BUB11.35193460
29WNK11.26132394
30TRPM71.23902670
31RPS6KA51.23784781
32PLK31.20092557
33SRPK11.18996920
34IRAK31.18661711
35ICK1.15142273
36BRSK11.11538228
37MAP2K31.10678607
38TSSK61.05765515
39ZAK1.05455464
40MAP2K11.04780747
41PBK1.00157996
42CDK120.99300909
43NEK10.99261040
44STK30.95229951
45NEK20.92925822
46MARK30.92037735
47JAK20.91127813
48ATR0.88213140
49BRAF0.88084172
50PLK10.87680246
51CHEK10.80469655
52MATK0.77455302
53MAP3K100.77153762
54MAP3K10.77113054
55NME20.75705134
56TEC0.75007538
57CAMK1D0.74514151
58RPS6KB20.73915626
59ATM0.72656299
60ALK0.64078427
61BTK0.62730685
62CDK10.60787687
63PDK20.59913929
64EIF2AK30.59189060
65CDK20.58731888
66PAK10.54968082
67RET0.50217465
68AURKB0.49206273
69MTOR0.48165389
70PLK20.47913222
71SGK10.46242314
72SYK0.44938922
73ILK0.43195942
74CDK40.42554786
75CSNK2A20.42038477
76AKT10.40206335
77JAK30.39567265
78MAPK110.39328546
79CSNK2A10.37570510
80MAPK120.36901578
81PRKAA10.35450829
82TLK10.34138696
83MAP3K60.34015893
84VRK10.33027553
85AKT20.32822284
86PRKACG0.32692904
87AURKA0.32255091
88STK160.32133181
89PTK2B0.31390580
90MAPKAPK50.31220126
91MAPK30.31122901
92CDK70.30884095
93MAP3K40.30691570
94PRKAA20.30144951
95MAP3K50.29700386
96BRD40.28032692
97MAPK140.27822768
98GRK60.27522921
99RPS6KA40.27004698
100MAPKAPK30.26424410

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.62749746
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.60408956
3DNA replication_Homo sapiens_hsa030303.47473177
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.43517465
5Mismatch repair_Homo sapiens_hsa034303.27745791
6One carbon pool by folate_Homo sapiens_hsa006702.85583555
7Homologous recombination_Homo sapiens_hsa034402.66736150
8Cell cycle_Homo sapiens_hsa041102.55241363
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21983995
10Nucleotide excision repair_Homo sapiens_hsa034202.18757773
11Fanconi anemia pathway_Homo sapiens_hsa034601.98806106
12RNA transport_Homo sapiens_hsa030131.86618162
13Spliceosome_Homo sapiens_hsa030401.84981409
14Pyruvate metabolism_Homo sapiens_hsa006201.75766496
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64429195
16Base excision repair_Homo sapiens_hsa034101.59269298
17Steroid biosynthesis_Homo sapiens_hsa001001.53379589
18Basal transcription factors_Homo sapiens_hsa030221.51259436
19Ribosome_Homo sapiens_hsa030101.49328124
20Acute myeloid leukemia_Homo sapiens_hsa052211.48855044
21Non-homologous end-joining_Homo sapiens_hsa034501.47096441
22Carbon metabolism_Homo sapiens_hsa012001.43347562
23Chronic myeloid leukemia_Homo sapiens_hsa052201.41149935
24Biosynthesis of amino acids_Homo sapiens_hsa012301.39749980
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33409180
26Non-small cell lung cancer_Homo sapiens_hsa052231.22257006
27mRNA surveillance pathway_Homo sapiens_hsa030151.22018337
28Proteasome_Homo sapiens_hsa030501.21558301
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20502027
30RNA polymerase_Homo sapiens_hsa030201.18610190
31Viral carcinogenesis_Homo sapiens_hsa052031.11580224
32Fructose and mannose metabolism_Homo sapiens_hsa000511.05003803
33Malaria_Homo sapiens_hsa051441.03483732
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.01980792
35Thyroid cancer_Homo sapiens_hsa052161.00891415
36Alcoholism_Homo sapiens_hsa050341.00834286
37Systemic lupus erythematosus_Homo sapiens_hsa053220.98784646
38Pancreatic cancer_Homo sapiens_hsa052120.98558453
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98156091
40Oocyte meiosis_Homo sapiens_hsa041140.95691615
41Olfactory transduction_Homo sapiens_hsa047400.95037110
42Pyrimidine metabolism_Homo sapiens_hsa002400.94979128
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92325725
44HIF-1 signaling pathway_Homo sapiens_hsa040660.91592440
45Renal cell carcinoma_Homo sapiens_hsa052110.87769489
46Parkinsons disease_Homo sapiens_hsa050120.87221764
47Type II diabetes mellitus_Homo sapiens_hsa049300.83470834
48Arginine biosynthesis_Homo sapiens_hsa002200.82897642
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82879845
50Pentose phosphate pathway_Homo sapiens_hsa000300.82537863
51Huntingtons disease_Homo sapiens_hsa050160.79548165
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79339125
53mTOR signaling pathway_Homo sapiens_hsa041500.78762197
54Purine metabolism_Homo sapiens_hsa002300.77734816
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76557055
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72390569
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71930255
58Oxidative phosphorylation_Homo sapiens_hsa001900.70859891
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.69826484
60RNA degradation_Homo sapiens_hsa030180.69281706
61Nitrogen metabolism_Homo sapiens_hsa009100.69199582
62Collecting duct acid secretion_Homo sapiens_hsa049660.66896139
63Bladder cancer_Homo sapiens_hsa052190.63979667
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63906309
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63280019
66Glutathione metabolism_Homo sapiens_hsa004800.63023547
67Hepatitis B_Homo sapiens_hsa051610.59146420
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58405460
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57795254
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56976106
71Fatty acid metabolism_Homo sapiens_hsa012120.56430510
72N-Glycan biosynthesis_Homo sapiens_hsa005100.56370646
73Apoptosis_Homo sapiens_hsa042100.55224480
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54697508
75Propanoate metabolism_Homo sapiens_hsa006400.53971092
76p53 signaling pathway_Homo sapiens_hsa041150.52555709
77VEGF signaling pathway_Homo sapiens_hsa043700.51899084
78Glioma_Homo sapiens_hsa052140.48717384
79Sulfur relay system_Homo sapiens_hsa041220.47885512
80Epstein-Barr virus infection_Homo sapiens_hsa051690.46906136
81ErbB signaling pathway_Homo sapiens_hsa040120.46886236
82MicroRNAs in cancer_Homo sapiens_hsa052060.45351756
83Insulin signaling pathway_Homo sapiens_hsa049100.45290125
84B cell receptor signaling pathway_Homo sapiens_hsa046620.45044459
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.44386642
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43257536
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42337110
88Metabolic pathways_Homo sapiens_hsa011000.41863904
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.41639083
90Fatty acid elongation_Homo sapiens_hsa000620.41305472
91AMPK signaling pathway_Homo sapiens_hsa041520.40959892
92Prolactin signaling pathway_Homo sapiens_hsa049170.38908213
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38870045
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37513084
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.36882520
96ABC transporters_Homo sapiens_hsa020100.36102221
97Prostate cancer_Homo sapiens_hsa052150.35518370
98Endometrial cancer_Homo sapiens_hsa052130.33432720
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32626482
100Platelet activation_Homo sapiens_hsa046110.30919100

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