HAUS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.34940803
2protein localization to kinetochore (GO:0034501)5.34302798
3nuclear pore organization (GO:0006999)5.33659467
4mitotic metaphase plate congression (GO:0007080)5.25228828
5DNA replication initiation (GO:0006270)4.71745286
6protein localization to chromosome, centromeric region (GO:0071459)4.63046181
7metaphase plate congression (GO:0051310)4.59741082
8DNA unwinding involved in DNA replication (GO:0006268)4.53001086
9DNA replication checkpoint (GO:0000076)4.51966921
10mitotic nuclear envelope disassembly (GO:0007077)4.41555152
11regulation of spindle organization (GO:0090224)4.39257015
12kinetochore organization (GO:0051383)4.36451761
13mitotic chromosome condensation (GO:0007076)4.32172976
14DNA strand elongation involved in DNA replication (GO:0006271)4.29471589
15positive regulation of chromosome segregation (GO:0051984)4.19180130
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.18167167
17DNA ligation (GO:0006266)4.16069697
18mitotic sister chromatid segregation (GO:0000070)4.15633832
19nuclear envelope disassembly (GO:0051081)4.13221003
20membrane disassembly (GO:0030397)4.13221003
21DNA replication-dependent nucleosome organization (GO:0034723)4.10942364
22DNA replication-dependent nucleosome assembly (GO:0006335)4.10942364
23CENP-A containing nucleosome assembly (GO:0034080)4.10781636
24pore complex assembly (GO:0046931)4.08774861
25DNA strand elongation (GO:0022616)4.08416999
26chromatin remodeling at centromere (GO:0031055)4.08340900
27regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.06565197
28sister chromatid segregation (GO:0000819)4.05231395
29attachment of spindle microtubules to kinetochore (GO:0008608)4.02554008
30establishment of integrated proviral latency (GO:0075713)4.00952933
31establishment of chromosome localization (GO:0051303)3.98069775
32mitotic sister chromatid cohesion (GO:0007064)3.97211301
33nucleobase biosynthetic process (GO:0046112)3.96452888
34mitotic recombination (GO:0006312)3.93775678
35telomere maintenance via semi-conservative replication (GO:0032201)3.92873148
36double-strand break repair via nonhomologous end joining (GO:0006303)3.92127370
37non-recombinational repair (GO:0000726)3.92127370
38regulation of mitotic spindle organization (GO:0060236)3.91189343
39DNA replication-independent nucleosome assembly (GO:0006336)3.90341267
40DNA replication-independent nucleosome organization (GO:0034724)3.90341267
41positive regulation of mitotic sister chromatid separation (GO:1901970)3.87672654
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.87672654
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.87672654
44telomere maintenance via recombination (GO:0000722)3.86552220
45purine nucleobase biosynthetic process (GO:0009113)3.84992568
46kinetochore assembly (GO:0051382)3.78946047
47regulation of DNA endoreduplication (GO:0032875)3.70690603
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.69225058
49ribosome assembly (GO:0042255)3.68079015
50IMP biosynthetic process (GO:0006188)3.66703038
51histone exchange (GO:0043486)3.66153291
52meiotic chromosome segregation (GO:0045132)3.63388110
53regulation of chromosome segregation (GO:0051983)3.55119365
54spindle checkpoint (GO:0031577)3.53714997
55protein K6-linked ubiquitination (GO:0085020)3.51340265
56negative regulation of DNA-dependent DNA replication (GO:2000104)3.50219176
57protein localization to chromosome (GO:0034502)3.49529753
58mitotic G2/M transition checkpoint (GO:0044818)3.49492940
59regulation of mitotic metaphase/anaphase transition (GO:0030071)3.46942878
60regulation of sister chromatid cohesion (GO:0007063)3.46121801
61DNA double-strand break processing (GO:0000729)3.44239018
62DNA duplex unwinding (GO:0032508)3.44032061
63DNA geometric change (GO:0032392)3.43662421
64DNA packaging (GO:0006323)3.40087634
65regulation of centrosome cycle (GO:0046605)3.39165823
66regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.38831719
67heterochromatin organization (GO:0070828)3.38568159
68L-serine metabolic process (GO:0006563)3.37548695
69chromatin assembly or disassembly (GO:0006333)3.37397632
70regulation of RNA export from nucleus (GO:0046831)3.36360421
71replication fork processing (GO:0031297)3.33793465
72regulation of centrosome duplication (GO:0010824)3.32175411
73chromosome segregation (GO:0007059)3.32000169
74folic acid-containing compound biosynthetic process (GO:0009396)3.31551464
75telomere maintenance via telomere lengthening (GO:0010833)3.31040932
76formation of translation preinitiation complex (GO:0001731)3.30541083
77negative regulation of chromosome segregation (GO:0051985)3.29027413
78ribosome biogenesis (GO:0042254)3.28567344
79spindle assembly checkpoint (GO:0071173)3.27628622
80nuclear envelope organization (GO:0006998)3.24382182
81negative regulation of mitotic sister chromatid separation (GO:2000816)3.24227922
82negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24227922
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24227922
84negative regulation of sister chromatid segregation (GO:0033046)3.24227922
85regulation of centriole replication (GO:0046599)3.24140662
86regulation of histone H3-K9 methylation (GO:0051570)3.24131575
87mitotic spindle checkpoint (GO:0071174)3.23912401
88regulation of sister chromatid segregation (GO:0033045)3.23886617
89regulation of mitotic sister chromatid separation (GO:0010965)3.23886617
90regulation of mitotic sister chromatid segregation (GO:0033047)3.23886617
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23776487
92IMP metabolic process (GO:0046040)3.23040229
93mitotic spindle assembly checkpoint (GO:0007094)3.18119785
94protein complex localization (GO:0031503)3.17076514
95nucleotide-excision repair, DNA gap filling (GO:0006297)3.14777582
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14399215
97ATP-dependent chromatin remodeling (GO:0043044)3.13920934
98mitochondrial RNA metabolic process (GO:0000959)3.13857353
99microtubule depolymerization (GO:0007019)3.13362484
100regulation of double-strand break repair via homologous recombination (GO:0010569)3.11581500
101regulation of helicase activity (GO:0051095)3.09978642
102negative regulation of DNA recombination (GO:0045910)3.08468483
103chromosome condensation (GO:0030261)3.05808485
104DNA conformation change (GO:0071103)3.05769703
105negative regulation of histone methylation (GO:0031061)3.05298034
106cellular protein complex localization (GO:0034629)3.03927600
107regulation of nuclear cell cycle DNA replication (GO:0033262)3.03809575
108pre-miRNA processing (GO:0031054)3.03193256
109somatic hypermutation of immunoglobulin genes (GO:0016446)3.02621382
110somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02621382
111regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01604654
112regulation of mitotic spindle checkpoint (GO:1903504)3.01604654
113sister chromatid cohesion (GO:0007062)2.98260315
114translesion synthesis (GO:0019985)2.95447191
115dosage compensation (GO:0007549)2.93157011
116maturation of SSU-rRNA (GO:0030490)2.91290391
117telomere maintenance (GO:0000723)2.90262370
118telomere organization (GO:0032200)2.88649848
119inner cell mass cell proliferation (GO:0001833)2.88169642
120DNA topological change (GO:0006265)2.88165185
121postreplication repair (GO:0006301)2.87053900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.56877067
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.49169415
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.77593385
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.64476529
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82024663
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80332040
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.74960662
8AR_21909140_ChIP-Seq_LNCAP_Human2.63379464
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58884959
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.56047772
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42877473
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.40608666
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38978037
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.36961861
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34379473
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30089506
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27540693
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.09557311
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.07497545
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07368033
21XRN2_22483619_ChIP-Seq_HELA_Human2.05862576
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01553025
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00636812
24E2F7_22180533_ChIP-Seq_HELA_Human10.6942207
25VDR_23849224_ChIP-Seq_CD4+_Human1.96769238
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91829390
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.88390984
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85848626
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79005845
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78331490
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73475239
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69592145
33FOXP3_21729870_ChIP-Seq_TREG_Human1.68746984
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.66265876
35ELK1_19687146_ChIP-ChIP_HELA_Human1.66201984
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65026789
37FUS_26573619_Chip-Seq_HEK293_Human1.63812511
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61478025
39MYC_22102868_ChIP-Seq_BL_Human1.61374697
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60732725
41EWS_26573619_Chip-Seq_HEK293_Human1.58554530
42TTF2_22483619_ChIP-Seq_HELA_Human1.55157047
43DCP1A_22483619_ChIP-Seq_HELA_Human1.53185232
44CIITA_25753668_ChIP-Seq_RAJI_Human1.50917883
45KDM5A_27292631_Chip-Seq_BREAST_Human1.49755174
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47148552
47GABP_19822575_ChIP-Seq_HepG2_Human1.46864047
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45016899
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44528022
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42065775
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41790148
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40458763
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40219543
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38654314
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37478972
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35949783
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31532933
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29643046
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25071499
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.23661509
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.23635913
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22969027
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22765027
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21722649
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21600561
66* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18334539
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15620189
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15308389
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15253385
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14679562
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13545188
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11633493
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10640416
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08880437
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07450489
76TFEB_21752829_ChIP-Seq_HELA_Human1.04750312
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.03926056
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01371349
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.00589187
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00304602
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97878039
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97061631
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95292275
84SOX17_20123909_ChIP-Seq_XEN_Mouse0.94109775
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92577628
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92091724
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91189964
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90217389
89MYC_18940864_ChIP-ChIP_HL60_Human0.89292413
90* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88580407
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87879061
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87879061
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87879061
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87460488
95ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86943594
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86828368
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86072160
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85039030
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83919865
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81978929
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81295820
102FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80229319
103VDR_21846776_ChIP-Seq_THP-1_Human0.79094988
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.78464381
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78348411
106TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77936321
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77694673
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77308880
109WT1_19549856_ChIP-ChIP_CCG9911_Human0.77212112
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76105808
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75723621
112TAF15_26573619_Chip-Seq_HEK293_Human0.74888689
113SOX9_26525672_Chip-Seq_HEART_Mouse0.74555109
114SRF_21415370_ChIP-Seq_HL-1_Mouse0.74460369
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.72330923
116IGF1R_20145208_ChIP-Seq_DFB_Human0.70039242
117TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69738923
118ZNF274_21170338_ChIP-Seq_K562_Hela0.69701120
119CHD1_26751641_Chip-Seq_LNCaP_Human0.68753144
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.68346401
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.66225843
122P300_19829295_ChIP-Seq_ESCs_Human0.63701066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.93013482
2MP0010094_abnormal_chromosome_stability4.69331752
3MP0008057_abnormal_DNA_replication4.56512387
4MP0003111_abnormal_nucleus_morphology4.41797092
5MP0004957_abnormal_blastocyst_morpholog4.01825832
6MP0003077_abnormal_cell_cycle3.96530740
7MP0008058_abnormal_DNA_repair3.13720445
8MP0008007_abnormal_cellular_replicative2.89745526
9MP0010307_abnormal_tumor_latency2.58139461
10MP0009697_abnormal_copulation2.56472844
11MP0008932_abnormal_embryonic_tissue2.52026354
12MP0003123_paternal_imprinting2.47517132
13MP0001730_embryonic_growth_arrest2.46960382
14MP0000350_abnormal_cell_proliferation2.41862775
15MP0010352_gastrointestinal_tract_polyps2.34985361
16MP0008877_abnormal_DNA_methylation2.32168038
17MP0002396_abnormal_hematopoietic_system2.22927674
18MP0005380_embryogenesis_phenotype1.99305758
19MP0001672_abnormal_embryogenesis/_devel1.99305758
20MP0001697_abnormal_embryo_size1.85540457
21MP0003984_embryonic_growth_retardation1.78240787
22MP0003786_premature_aging1.77303981
23MP0002088_abnormal_embryonic_growth/wei1.75146148
24MP0005076_abnormal_cell_differentiation1.73479520
25MP0002085_abnormal_embryonic_tissue1.70630801
26MP0002084_abnormal_developmental_patter1.70492811
27MP0004808_abnormal_hematopoietic_stem1.69923072
28MP0002086_abnormal_extraembryonic_tissu1.63645222
29MP0004197_abnormal_fetal_growth/weight/1.63291561
30MP0002080_prenatal_lethality1.60189100
31MP0003718_maternal_effect1.60018768
32MP0003121_genomic_imprinting1.57789913
33MP0000490_abnormal_crypts_of1.55288815
34MP0002938_white_spotting1.48643152
35MP0003567_abnormal_fetal_cardiomyocyte1.45741529
36MP0001293_anophthalmia1.42741478
37MP0000313_abnormal_cell_death1.36136024
38MP0002019_abnormal_tumor_incidence1.33731919
39MP0010030_abnormal_orbit_morphology1.33260684
40MP0001661_extended_life_span1.32711631
41MP0003890_abnormal_embryonic-extraembry1.27198265
42MP0002210_abnormal_sex_determination1.26037887
43MP0005397_hematopoietic_system_phenotyp1.25041123
44MP0001545_abnormal_hematopoietic_system1.25041123
45MP0004185_abnormal_adipocyte_glucose1.21883707
46MP0009053_abnormal_anal_canal1.16957675
47MP0003937_abnormal_limbs/digits/tail_de1.15621526
48MP0003705_abnormal_hypodermis_morpholog1.13181875
49MP0001145_abnormal_male_reproductive1.09056795
50MP0002233_abnormal_nose_morphology1.06662438
51MP0006072_abnormal_retinal_apoptosis1.06606960
52MP0003941_abnormal_skin_development1.04834529
53MP0003315_abnormal_perineum_morphology1.03578385
54MP0008995_early_reproductive_senescence1.02952576
55MP0000703_abnormal_thymus_morphology1.00242186
56MP0001929_abnormal_gametogenesis0.99670234
57MP0009333_abnormal_splenocyte_physiolog0.99327002
58MP0009672_abnormal_birth_weight0.95938408
59MP0000653_abnormal_sex_gland0.95694997
60MP0009703_decreased_birth_body0.94704717
61MP0000647_abnormal_sebaceous_gland0.92151074
62MP0002234_abnormal_pharynx_morphology0.91604843
63MP0000537_abnormal_urethra_morphology0.90892827
64MP0003221_abnormal_cardiomyocyte_apopto0.90786858
65MP0002398_abnormal_bone_marrow0.90528515
66MP0003385_abnormal_body_wall0.89617503
67MP0002092_abnormal_eye_morphology0.88784356
68MP0000733_abnormal_muscle_development0.86878349
69MP0000428_abnormal_craniofacial_morphol0.86167975
70MP0001119_abnormal_female_reproductive0.85458258
71MP0005621_abnormal_cell_physiology0.83813785
72MP0001915_intracranial_hemorrhage0.83795222
73MP0000432_abnormal_head_morphology0.82910170
74MP0002722_abnormal_immune_system0.82906037
75MP0003136_yellow_coat_color0.82451651
76MP0005391_vision/eye_phenotype0.81944761
77MP0002111_abnormal_tail_morphology0.80301247
78MP0006292_abnormal_olfactory_placode0.80007491
79MP0005384_cellular_phenotype0.79748983
80MP0000579_abnormal_nail_morphology0.79627320
81MP0006035_abnormal_mitochondrial_morpho0.79459675
82MP0000689_abnormal_spleen_morphology0.79037323
83MP0000358_abnormal_cell_content/0.77765068
84MP0001286_abnormal_eye_development0.77297315
85MP0005394_taste/olfaction_phenotype0.76721735
86MP0005499_abnormal_olfactory_system0.76721735
87MP0003119_abnormal_digestive_system0.76718720
88MP0005187_abnormal_penis_morphology0.76602721
89MP0003942_abnormal_urinary_system0.76375112
90MP0000569_abnormal_digit_pigmentation0.76157145
91MP0000049_abnormal_middle_ear0.76122403
92MP0003763_abnormal_thymus_physiology0.75375195
93MP0003566_abnormal_cell_adhesion0.74931259
94MP0003698_abnormal_male_reproductive0.74447261
95MP0003935_abnormal_craniofacial_develop0.72556704
96MP0008789_abnormal_olfactory_epithelium0.72164180
97MP0009278_abnormal_bone_marrow0.71383971
98MP0002877_abnormal_melanocyte_morpholog0.71301374
99MP0002160_abnormal_reproductive_system0.69733250
100MP0001177_atelectasis0.69728134
101MP0001188_hyperpigmentation0.68934150
102MP0000383_abnormal_hair_follicle0.68441856
103MP0005023_abnormal_wound_healing0.67881862
104MP0001849_ear_inflammation0.67332233
105MP0000631_abnormal_neuroendocrine_gland0.66796498
106MP0002081_perinatal_lethality0.66376452
107MP0002925_abnormal_cardiovascular_devel0.65418154
108MP0002006_tumorigenesis0.65267243
109MP0003755_abnormal_palate_morphology0.65144923
110MP0004264_abnormal_extraembryonic_tissu0.65059224
111MP0004233_abnormal_muscle_weight0.64767738
112MP0005623_abnormal_meninges_morphology0.64324022
113MP0000516_abnormal_urinary_system0.64322362
114MP0005367_renal/urinary_system_phenotyp0.64322362
115MP0005253_abnormal_eye_physiology0.64214035
116MP0006054_spinal_hemorrhage0.63786663
117MP0002697_abnormal_eye_size0.62541698
118MP0000627_abnormal_mammary_gland0.62184927
119MP0002161_abnormal_fertility/fecundity0.62178518
120MP0002751_abnormal_autonomic_nervous0.62098632
121MP0003448_altered_tumor_morphology0.62063096
122MP0002009_preneoplasia0.61715368
123MP0002429_abnormal_blood_cell0.61563011
124MP0003115_abnormal_respiratory_system0.59813279
125MP0000858_altered_metastatic_potential0.59204507
126MP0000477_abnormal_intestine_morphology0.58451683
127MP0010678_abnormal_skin_adnexa0.58400975
128MP0010234_abnormal_vibrissa_follicle0.57932510
129MP0002166_altered_tumor_susceptibility0.57884129
130MP0003699_abnormal_female_reproductive0.57526855
131MP0003787_abnormal_imprinting0.57145949
132MP0005389_reproductive_system_phenotype0.56882123
133MP0003861_abnormal_nervous_system0.55864169

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.23431385
2Chromsome breakage (HP:0040012)4.39675965
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.12111864
4Breast hypoplasia (HP:0003187)3.85085282
5Impulsivity (HP:0100710)3.62415181
6Abnormality of chromosome stability (HP:0003220)3.57397190
7Patellar aplasia (HP:0006443)3.54497028
8Aplasia/Hypoplasia of the patella (HP:0006498)3.35089139
9Meckel diverticulum (HP:0002245)3.27081937
10Abnormality of the labia minora (HP:0012880)3.17058052
11Abnormality of the preputium (HP:0100587)3.12158889
12Selective tooth agenesis (HP:0001592)3.11455747
13Abnormality of the ileum (HP:0001549)3.08627121
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.04693858
15Ependymoma (HP:0002888)3.04117512
16Medulloblastoma (HP:0002885)3.01880960
17Cortical dysplasia (HP:0002539)2.90189897
18Colon cancer (HP:0003003)2.87520672
19Ectopic kidney (HP:0000086)2.82569631
20Absent radius (HP:0003974)2.74681542
21Duodenal stenosis (HP:0100867)2.74364268
22Small intestinal stenosis (HP:0012848)2.74364268
23Reticulocytopenia (HP:0001896)2.73779884
24Volvulus (HP:0002580)2.70131284
25Rhabdomyosarcoma (HP:0002859)2.69966029
26Myelodysplasia (HP:0002863)2.69719498
27Facial hemangioma (HP:0000329)2.62877769
28Deviation of the thumb (HP:0009603)2.62073640
29Carpal bone hypoplasia (HP:0001498)2.61511757
30Proximal placement of thumb (HP:0009623)2.60595824
31Abnormality of alanine metabolism (HP:0010916)2.59838518
32Hyperalaninemia (HP:0003348)2.59838518
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59838518
34Absent forearm bone (HP:0003953)2.55066358
35Aplasia involving forearm bones (HP:0009822)2.55066358
36Increased nuchal translucency (HP:0010880)2.46233160
37Abnormality of the anterior horn cell (HP:0006802)2.45476132
38Degeneration of anterior horn cells (HP:0002398)2.45476132
39Prominent nose (HP:0000448)2.45373918
40Oral leukoplakia (HP:0002745)2.41187742
41Agnosia (HP:0010524)2.38460086
42Atresia of the external auditory canal (HP:0000413)2.37706914
43Absent thumb (HP:0009777)2.35591493
44Arteriovenous malformation (HP:0100026)2.35441192
45Sloping forehead (HP:0000340)2.34040761
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33418408
47Short 4th metacarpal (HP:0010044)2.33418408
48Abnormality of the duodenum (HP:0002246)2.26341103
49Neoplasm of the pancreas (HP:0002894)2.25255687
50Astrocytoma (HP:0009592)2.23979325
51Abnormality of the astrocytes (HP:0100707)2.23979325
52Cafe-au-lait spot (HP:0000957)2.23317891
53Abnormal number of incisors (HP:0011064)2.22581414
54Rough bone trabeculation (HP:0100670)2.22511220
55Abnormality of the carotid arteries (HP:0005344)2.21659144
56Basal cell carcinoma (HP:0002671)2.21194231
57Short thumb (HP:0009778)2.16879125
58Bone marrow hypocellularity (HP:0005528)2.16722991
59Squamous cell carcinoma (HP:0002860)2.14051388
60Abnormal umbilical cord blood vessels (HP:0011403)2.13935112
61Single umbilical artery (HP:0001195)2.13935112
62Abnormality of the fetal cardiovascular system (HP:0010948)2.13935112
63Embryonal neoplasm (HP:0002898)2.13923276
64Supernumerary spleens (HP:0009799)2.13707011
65Premature graying of hair (HP:0002216)2.12100188
66Nephroblastoma (Wilms tumor) (HP:0002667)2.11168336
67Abnormal lung lobation (HP:0002101)2.11007700
68Glioma (HP:0009733)2.10263093
69Tracheoesophageal fistula (HP:0002575)2.09681084
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.08787596
71Hepatoblastoma (HP:0002884)2.03545511
72Neoplasm of the colon (HP:0100273)1.99555626
73Intestinal atresia (HP:0011100)1.99097352
74Abnormality of cells of the erythroid lineage (HP:0012130)1.99041613
75Embryonal renal neoplasm (HP:0011794)1.98750880
76Multiple enchondromatosis (HP:0005701)1.98733139
77High pitched voice (HP:0001620)1.98359391
78Abnormality of homocysteine metabolism (HP:0010919)1.97930196
79Homocystinuria (HP:0002156)1.97930196
80Aplasia/hypoplasia of the humerus (HP:0006507)1.97813161
81Abnormality of the fingertips (HP:0001211)1.96688686
82Long eyelashes (HP:0000527)1.96271140
83Horseshoe kidney (HP:0000085)1.95765404
84Neoplasm of striated muscle (HP:0009728)1.95545126
85Sparse lateral eyebrow (HP:0005338)1.94998509
86Neoplasm of the oral cavity (HP:0100649)1.94794517
87Acute myeloid leukemia (HP:0004808)1.93606044
88Amaurosis fugax (HP:0100576)1.92426937
89Abnormal number of erythroid precursors (HP:0012131)1.92392052
90Clubbing of toes (HP:0100760)1.92351100
91Biliary tract neoplasm (HP:0100574)1.91035557
92Cutaneous melanoma (HP:0012056)1.90361598
93Slender long bone (HP:0003100)1.89232567
94Triphalangeal thumb (HP:0001199)1.88980951
95Microtia (HP:0008551)1.88461135
96Neoplasm of the adrenal cortex (HP:0100641)1.88337444
97Breast aplasia (HP:0100783)1.87912414
98Entropion (HP:0000621)1.87305953
99Abnormality of serum amino acid levels (HP:0003112)1.86916273
100Aplastic anemia (HP:0001915)1.86529927
101Deep philtrum (HP:0002002)1.85263319
102Oligodactyly (HP:0012165)1.84795419
103Abnormality of cochlea (HP:0000375)1.84743115
104Uterine leiomyosarcoma (HP:0002891)1.83791466
105Leiomyosarcoma (HP:0100243)1.83791466
10611 pairs of ribs (HP:0000878)1.83602881
107Pelvic girdle muscle weakness (HP:0003749)1.83391430
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82463105
109Abnormality of DNA repair (HP:0003254)1.81258802
110Esophageal atresia (HP:0002032)1.80711859
111Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79880905
112Duplicated collecting system (HP:0000081)1.78345805
113Sandal gap (HP:0001852)1.77462940
114Overlapping toe (HP:0001845)1.76536412
115Abnormality of methionine metabolism (HP:0010901)1.75942725
116Aplasia/Hypoplasia of the breasts (HP:0010311)1.75663119
117Short humerus (HP:0005792)1.74467861
118Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74069525
119Gastrointestinal atresia (HP:0002589)1.73304717
120Duplication of thumb phalanx (HP:0009942)1.72842356
121Transitional cell carcinoma of the bladder (HP:0006740)1.71524759
122Facial cleft (HP:0002006)1.71461095
123Ankle contracture (HP:0006466)1.71238501
124Progressive external ophthalmoplegia (HP:0000590)1.70918586
125Cellular immunodeficiency (HP:0005374)1.70251371
126Abnormality of chromosome segregation (HP:0002916)1.69710599
127Choanal atresia (HP:0000453)1.69106319
128Gastrointestinal carcinoma (HP:0002672)1.68965891
129Malignant gastrointestinal tract tumors (HP:0006749)1.68965891
130Abnormal trabecular bone morphology (HP:0100671)1.67551574
131High anterior hairline (HP:0009890)1.66850736
132Microvesicular hepatic steatosis (HP:0001414)1.66765176
133Missing ribs (HP:0000921)1.66264765
134Short middle phalanx of the 5th finger (HP:0004220)1.64133719
135Oligodactyly (hands) (HP:0001180)1.63785021
136Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63155615
137Abnormality of the umbilical cord (HP:0010881)1.61659899
138Small hand (HP:0200055)1.61279443
139Diastasis recti (HP:0001540)1.59822531
140Uterine neoplasm (HP:0010784)1.59574910
141Abnormality of the septum pellucidum (HP:0007375)1.59155551
142Stenosis of the external auditory canal (HP:0000402)1.58657329
143Ovarian neoplasm (HP:0100615)1.57169494
144Bladder carcinoma (HP:0002862)1.55222634
145Bladder neoplasm (HP:0009725)1.55222634
146Intestinal polyposis (HP:0200008)1.52642131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.86202613
2WEE14.19409239
3BUB13.69876357
4NEK23.48641828
5CDK123.02337419
6SRPK12.63162577
7PBK2.62398264
8EIF2AK12.62193777
9TTK2.61209153
10NEK12.50191344
11BRSK22.47600663
12MKNK12.42993852
13PLK42.25850151
14MKNK22.22227844
15PLK12.17948927
16ACVR1B2.07014684
17PLK31.97304205
18TSSK61.89382305
19AURKB1.88233106
20TAF11.85519125
21ATR1.83798377
22CHEK21.80240504
23CDK71.69586531
24RPS6KA41.62286928
25CDK41.61758986
26EIF2AK31.61729735
27CHEK11.49202448
28TLK11.45516574
29STK31.44699731
30DYRK31.43659191
31VRK11.42432051
32RPS6KB21.38690291
33MAP3K81.36832005
34BRSK11.35291657
35STK101.33817788
36TRIM281.33782580
37LATS11.32890198
38CDK61.28466648
39PASK1.27448407
40STK41.27273569
41EEF2K1.25038076
42ZAK1.23861757
43TESK21.20161999
44ATM1.18166608
45TNIK1.13397918
46ERBB31.12901502
47VRK21.10427414
48BCR1.09625290
49PIM11.09162021
50ALK1.07694151
51BRD41.03984377
52CDK21.03959020
53BMPR1B0.99851867
54AURKA0.97610633
55NME20.97580365
56PLK20.96672361
57MST40.95031203
58MELK0.90762197
59EPHA20.89298344
60CCNB10.88138328
61SCYL20.83664431
62LATS20.81963886
63CDK10.81415843
64WNK30.77432750
65TGFBR10.76309117
66CAMK1G0.75965311
67ERBB40.75915340
68PAK40.72484721
69STK38L0.71824284
70EIF2AK20.69926264
71MTOR0.69100088
72PKN20.65690923
73MAP3K100.62448564
74CSNK1G10.62372719
75MARK30.59206054
76CSNK2A20.58353730
77NEK90.56812778
78RPS6KA50.53403334
79CSNK2A10.51465266
80PAK10.48378342
81FLT30.47969624
82PNCK0.47891618
83CDK80.47535834
84SMG10.47351875
85CSNK1D0.41760954
86CSNK1E0.41357265
87MAP3K40.40315478
88PRKDC0.40271647
89MAPK140.40155267
90PDK20.38879094
91CSNK1A1L0.38770837
92STK160.38603886
93CSNK1G30.36863985
94AKT30.36687228
95PAK20.36490968
96LRRK20.36472799
97NUAK10.36353030
98STK390.35623650
99TTN0.35573306
100PRKCI0.35280537
101FGFR10.35124539
102CDK30.35095336
103CLK10.34539744
104RPS6KB10.33826552
105MAP4K10.32265456
106NLK0.32165821
107YES10.31785026
108AKT20.28363784
109MAPK10.28349188
110CSNK1G20.28150034
111CDK190.27045648
112AKT10.26869147
113MAP4K20.26738426
114NEK60.26474840
115BRAF0.26208064
116CDK90.26205216
117GSK3B0.25023933
118FRK0.24114050
119TEC0.24018326
120CAMK1D0.23848719
121CHUK0.21500880
122JAK30.20525560
123STK240.18877318
124CSF1R0.17882608
125MAPK100.15595321
126TESK10.14911665

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.72718953
2Mismatch repair_Homo sapiens_hsa034304.06766008
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.80975021
4RNA transport_Homo sapiens_hsa030133.40367686
5Cell cycle_Homo sapiens_hsa041103.39994417
6Spliceosome_Homo sapiens_hsa030403.19989707
7Homologous recombination_Homo sapiens_hsa034403.11205559
8RNA polymerase_Homo sapiens_hsa030202.84069985
9Base excision repair_Homo sapiens_hsa034102.80247101
10Nucleotide excision repair_Homo sapiens_hsa034202.79804578
11One carbon pool by folate_Homo sapiens_hsa006702.66302997
12Fanconi anemia pathway_Homo sapiens_hsa034602.63120891
13Non-homologous end-joining_Homo sapiens_hsa034502.24042485
14Basal transcription factors_Homo sapiens_hsa030222.16797573
15mRNA surveillance pathway_Homo sapiens_hsa030152.09966128
16p53 signaling pathway_Homo sapiens_hsa041152.07111965
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06498488
18Pyrimidine metabolism_Homo sapiens_hsa002402.05675088
19RNA degradation_Homo sapiens_hsa030181.98567299
20Ribosome_Homo sapiens_hsa030101.91904068
21Proteasome_Homo sapiens_hsa030501.77786310
22Protein export_Homo sapiens_hsa030601.59971708
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50590901
24Systemic lupus erythematosus_Homo sapiens_hsa053221.50375258
25Vitamin B6 metabolism_Homo sapiens_hsa007501.36834193
26Viral carcinogenesis_Homo sapiens_hsa052031.30019394
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29920416
28Oocyte meiosis_Homo sapiens_hsa041141.27635936
29Epstein-Barr virus infection_Homo sapiens_hsa051691.26644183
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23357136
31Propanoate metabolism_Homo sapiens_hsa006401.17935466
32MicroRNAs in cancer_Homo sapiens_hsa052061.16031421
33Herpes simplex infection_Homo sapiens_hsa051681.15378882
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13416477
35Pyruvate metabolism_Homo sapiens_hsa006201.13051831
36Purine metabolism_Homo sapiens_hsa002301.08401844
37Steroid biosynthesis_Homo sapiens_hsa001001.06330857
38Small cell lung cancer_Homo sapiens_hsa052221.02255099
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99633041
40HTLV-I infection_Homo sapiens_hsa051660.96789225
41Antigen processing and presentation_Homo sapiens_hsa046120.92877616
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91052539
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85125765
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84718718
45Thyroid cancer_Homo sapiens_hsa052160.83941792
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81491727
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80027944
48Carbon metabolism_Homo sapiens_hsa012000.77321790
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73056039
50TGF-beta signaling pathway_Homo sapiens_hsa043500.71358024
51Pentose phosphate pathway_Homo sapiens_hsa000300.70859039
52Selenocompound metabolism_Homo sapiens_hsa004500.69203301
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68135986
54Chronic myeloid leukemia_Homo sapiens_hsa052200.65371665
55Hippo signaling pathway_Homo sapiens_hsa043900.61912362
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61579405
57Hepatitis B_Homo sapiens_hsa051610.60952518
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.60140088
59Colorectal cancer_Homo sapiens_hsa052100.59903082
60Biosynthesis of amino acids_Homo sapiens_hsa012300.59638656
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55612255
62Measles_Homo sapiens_hsa051620.54422090
63Alcoholism_Homo sapiens_hsa050340.54177242
64Apoptosis_Homo sapiens_hsa042100.53150140
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.52496880
66Adherens junction_Homo sapiens_hsa045200.52305393
67Prostate cancer_Homo sapiens_hsa052150.51691482
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50982074
69Basal cell carcinoma_Homo sapiens_hsa052170.50136547
70Legionellosis_Homo sapiens_hsa051340.49842324
71mTOR signaling pathway_Homo sapiens_hsa041500.49164042
72Primary immunodeficiency_Homo sapiens_hsa053400.46628316
73N-Glycan biosynthesis_Homo sapiens_hsa005100.44287942
74Influenza A_Homo sapiens_hsa051640.44169502
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.43934447
76Notch signaling pathway_Homo sapiens_hsa043300.41873205
77Pathways in cancer_Homo sapiens_hsa052000.41446416
78Shigellosis_Homo sapiens_hsa051310.41327382
79Viral myocarditis_Homo sapiens_hsa054160.40932602
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.40686717
81Lysine degradation_Homo sapiens_hsa003100.40098491
82Folate biosynthesis_Homo sapiens_hsa007900.39971623
83Bladder cancer_Homo sapiens_hsa052190.39787879
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39398745
85FoxO signaling pathway_Homo sapiens_hsa040680.38994925
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38648917
87Pancreatic cancer_Homo sapiens_hsa052120.37735900
88Non-small cell lung cancer_Homo sapiens_hsa052230.37364029
89HIF-1 signaling pathway_Homo sapiens_hsa040660.36400022
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.33821427
91Fatty acid elongation_Homo sapiens_hsa000620.33675415
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32885815
93Proteoglycans in cancer_Homo sapiens_hsa052050.32309063
94Endometrial cancer_Homo sapiens_hsa052130.32004100
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31918363
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.31274856
97Fatty acid metabolism_Homo sapiens_hsa012120.29287887
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28246098
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28121293
100Arginine biosynthesis_Homo sapiens_hsa002200.28097547
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28007274
102Fatty acid biosynthesis_Homo sapiens_hsa000610.26605301
103Acute myeloid leukemia_Homo sapiens_hsa052210.26172087
104Melanoma_Homo sapiens_hsa052180.26015724
105Hedgehog signaling pathway_Homo sapiens_hsa043400.25896764
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.25822567
107Metabolic pathways_Homo sapiens_hsa011000.25697394
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24658354
109Hematopoietic cell lineage_Homo sapiens_hsa046400.23983628
110Tight junction_Homo sapiens_hsa045300.23943229
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21827357
112T cell receptor signaling pathway_Homo sapiens_hsa046600.21285562
113B cell receptor signaling pathway_Homo sapiens_hsa046620.21206816
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21062872
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21001356
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20627968
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.20532843
118Wnt signaling pathway_Homo sapiens_hsa043100.20482247
119Glutathione metabolism_Homo sapiens_hsa004800.16910352
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16839871
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16698592
122Renal cell carcinoma_Homo sapiens_hsa052110.16618122
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16195338
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15313553
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15272579
126Toxoplasmosis_Homo sapiens_hsa051450.15039300
127Butanoate metabolism_Homo sapiens_hsa006500.14855678
128Sulfur relay system_Homo sapiens_hsa041220.13227025
129Arginine and proline metabolism_Homo sapiens_hsa003300.11695404
130Glioma_Homo sapiens_hsa052140.08971826
131Huntingtons disease_Homo sapiens_hsa050160.08441997
132Nitrogen metabolism_Homo sapiens_hsa009100.07636074

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