HAUS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.40907321
2telomere maintenance via semi-conservative replication (GO:0032201)5.21154889
3DNA deamination (GO:0045006)5.16608337
4DNA strand elongation (GO:0022616)5.13433623
5DNA replication initiation (GO:0006270)4.96191949
6ribosomal small subunit assembly (GO:0000028)4.72197808
7DNA unwinding involved in DNA replication (GO:0006268)4.70674320
8telomere maintenance via recombination (GO:0000722)4.59159987
9DNA replication checkpoint (GO:0000076)4.42730596
10mitotic recombination (GO:0006312)4.24944640
11protein localization to kinetochore (GO:0034501)4.18578262
12telomere maintenance via telomere lengthening (GO:0010833)3.99834536
13nucleotide-excision repair, DNA gap filling (GO:0006297)3.97597415
14CENP-A containing nucleosome assembly (GO:0034080)3.97215466
15chromatin remodeling at centromere (GO:0031055)3.94315937
16protein localization to chromosome, centromeric region (GO:0071459)3.92623511
17response to peptidoglycan (GO:0032494)3.92108038
18maturation of SSU-rRNA (GO:0030490)3.87827094
19nucleobase biosynthetic process (GO:0046112)3.81799333
20viral transcription (GO:0019083)3.80439842
21positive regulation of gamma-delta T cell activation (GO:0046645)3.79803734
22mitotic metaphase plate congression (GO:0007080)3.74093971
23translational termination (GO:0006415)3.73272985
24formation of translation preinitiation complex (GO:0001731)3.71388526
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.69672817
26folic acid-containing compound biosynthetic process (GO:0009396)3.66179975
27DNA replication-independent nucleosome organization (GO:0034724)3.64960344
28DNA replication-independent nucleosome assembly (GO:0006336)3.64960344
29mitotic nuclear envelope disassembly (GO:0007077)3.62366174
30neutrophil activation involved in immune response (GO:0002283)3.60306550
31DNA replication-dependent nucleosome organization (GO:0034723)3.59099985
32DNA replication-dependent nucleosome assembly (GO:0006335)3.59099985
33positive regulation by symbiont of host defense response (GO:0052509)3.56492622
34modulation by symbiont of host defense response (GO:0052031)3.56492622
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.56492622
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.56492622
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.56492622
38modulation by symbiont of host immune response (GO:0052553)3.56492622
39translational elongation (GO:0006414)3.50606926
40purine nucleobase biosynthetic process (GO:0009113)3.47401725
41mitotic chromosome condensation (GO:0007076)3.47377386
42kinetochore organization (GO:0051383)3.46687804
43pinocytosis (GO:0006907)3.46580043
44ribosomal small subunit biogenesis (GO:0042274)3.39081127
45IMP biosynthetic process (GO:0006188)3.36669363
46histone exchange (GO:0043486)3.36591213
47metaphase plate congression (GO:0051310)3.34300982
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33265831
49attachment of spindle microtubules to kinetochore (GO:0008608)3.32613382
50nuclear envelope disassembly (GO:0051081)3.31075280
51membrane disassembly (GO:0030397)3.31075280
52pentose-phosphate shunt (GO:0006098)3.30693755
53translational initiation (GO:0006413)3.30299716
54mitotic sister chromatid segregation (GO:0000070)3.27990031
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.21555969
56translesion synthesis (GO:0019985)3.20498589
57IMP metabolic process (GO:0046040)3.19269567
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18783904
59positive regulation of B cell differentiation (GO:0045579)3.17776397
60ribonucleoprotein complex biogenesis (GO:0022613)3.17135216
61kinetochore assembly (GO:0051382)3.16377358
62ribosome biogenesis (GO:0042254)3.16168995
63ribosomal large subunit biogenesis (GO:0042273)3.14779494
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.13551501
65establishment of chromosome localization (GO:0051303)3.11999526
66detection of other organism (GO:0098543)3.11528409
67cotranslational protein targeting to membrane (GO:0006613)3.11481319
68protein targeting to ER (GO:0045047)3.10041287
69NADPH regeneration (GO:0006740)3.09626478
70transcription-coupled nucleotide-excision repair (GO:0006283)3.08441336
71telomere maintenance (GO:0000723)3.07286231
72meiotic chromosome segregation (GO:0045132)3.07171349
73regulation of spindle organization (GO:0090224)3.06797303
74telomere organization (GO:0032200)3.06765628
75detection of bacterium (GO:0016045)3.00517238
76rRNA processing (GO:0006364)3.00196918
77pseudouridine synthesis (GO:0001522)2.98584337
78chromatin assembly or disassembly (GO:0006333)2.96248345
79maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96006687
80immunoglobulin mediated immune response (GO:0016064)2.95680972
81protein localization to endoplasmic reticulum (GO:0070972)2.95020356
82somatic hypermutation of immunoglobulin genes (GO:0016446)2.94846208
83somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94846208
84spliceosomal snRNP assembly (GO:0000387)2.94561723
85establishment of protein localization to endoplasmic reticulum (GO:0072599)2.92176779
86negative regulation of erythrocyte differentiation (GO:0045647)2.91819185
87cellular protein complex disassembly (GO:0043624)2.91633974
88viral life cycle (GO:0019058)2.91204387
89G1/S transition of mitotic cell cycle (GO:0000082)2.90699722
90cell cycle G1/S phase transition (GO:0044843)2.90699722
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90522073
92DNA duplex unwinding (GO:0032508)2.90510008
93rRNA metabolic process (GO:0016072)2.90481970
94DNA geometric change (GO:0032392)2.88621497
95mismatch repair (GO:0006298)2.88338679
96ribosome assembly (GO:0042255)2.87444706
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86699190
98proteasome assembly (GO:0043248)2.86436765
99respiratory burst (GO:0045730)2.86297926
100sister chromatid segregation (GO:0000819)2.85657407
101protein localization to chromosome (GO:0034502)2.84926538
102folic acid metabolic process (GO:0046655)2.84212697
103DNA topological change (GO:0006265)2.82838940
104base-excision repair (GO:0006284)2.82813377
105regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80371942
106establishment of integrated proviral latency (GO:0075713)2.79022640
107postreplication repair (GO:0006301)2.78685914
1083-UTR-mediated mRNA stabilization (GO:0070935)2.78422554
109B cell mediated immunity (GO:0019724)2.77778261
110negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77298528
111regulation of nuclear cell cycle DNA replication (GO:0033262)2.76386769
112protein K6-linked ubiquitination (GO:0085020)2.75999004
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75774864
114nuclear pore organization (GO:0006999)2.74573907
115DNA replication (GO:0006260)2.73498572
116pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.72432712
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.72378444
118maturation of 5.8S rRNA (GO:0000460)2.71905215
119DNA conformation change (GO:0071103)2.71779814
120rRNA modification (GO:0000154)2.71512898
121nuclear-transcribed mRNA catabolic process (GO:0000956)2.71443159
122detection of external biotic stimulus (GO:0098581)2.65075807
123negative regulation of phagocytosis (GO:0050765)2.61202281
124regulation of gamma-delta T cell activation (GO:0046643)2.60695092
125antigen processing and presentation of endogenous antigen (GO:0019883)2.57480515
126negative regulation of interleukin-12 production (GO:0032695)2.55135486
127nuclear pore complex assembly (GO:0051292)2.52471512
128DNA ligation (GO:0006266)2.52207824
129detection of molecule of bacterial origin (GO:0032490)2.50864834
130cellular extravasation (GO:0045123)2.50862715
131response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.49544506
132response to host immune response (GO:0052572)2.49544506
133positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.49536660
134regulation of mast cell degranulation (GO:0043304)2.48913068
135regulation of superoxide anion generation (GO:0032928)2.45333713
136glucose catabolic process (GO:0006007)2.45308475
137regulation of myeloid leukocyte mediated immunity (GO:0002886)2.44940305
138pentose metabolic process (GO:0019321)2.43637586
139cellular hyperosmotic response (GO:0071474)2.39849105
140regulation of gamma-delta T cell differentiation (GO:0045586)2.39725694
141detection of biotic stimulus (GO:0009595)2.37365084
142regulation of B cell differentiation (GO:0045577)2.36380039
143purine nucleobase metabolic process (GO:0006144)2.34055055
144antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.32438216
145viral mRNA export from host cell nucleus (GO:0046784)2.29757681
146regulation of B cell receptor signaling pathway (GO:0050855)2.28649678
147response to host (GO:0075136)2.28479426
148response to host defenses (GO:0052200)2.28479426
149response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.28479426
150positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.28314155
151pyrimidine nucleoside salvage (GO:0043097)2.27141710
152pyrimidine-containing compound salvage (GO:0008655)2.27141710
153regulation of histone H3-K9 methylation (GO:0051570)2.25638725
154regulation of leukocyte degranulation (GO:0043300)2.25496567
155DNA synthesis involved in DNA repair (GO:0000731)2.24419104
156proline biosynthetic process (GO:0006561)2.23839809
157antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.21719129
158macrophage activation involved in immune response (GO:0002281)2.21709981
159response to muramyl dipeptide (GO:0032495)2.20400479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.69954287
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.89745163
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76856425
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.75722217
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37849361
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08814850
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.82816314
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73052391
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.63632213
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63327879
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57118104
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56331671
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.55909671
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.52699581
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41602872
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27349641
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17456010
18XRN2_22483619_ChIP-Seq_HELA_Human2.14869307
19VDR_23849224_ChIP-Seq_CD4+_Human2.11457366
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10398929
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10093224
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06650752
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05581686
24AR_21909140_ChIP-Seq_LNCAP_Human2.02218227
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99325854
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.95711316
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92698563
28FOXP3_21729870_ChIP-Seq_TREG_Human1.90942365
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86049571
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.85845076
31* DCP1A_22483619_ChIP-Seq_HELA_Human1.84227364
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.83842748
33GABP_19822575_ChIP-Seq_HepG2_Human1.83628325
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83601509
35MYC_22102868_ChIP-Seq_BL_Human1.82129428
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71422300
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68562459
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65620874
39TTF2_22483619_ChIP-Seq_HELA_Human1.60932014
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59681848
41CIITA_25753668_ChIP-Seq_RAJI_Human1.59197405
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58279498
43VDR_24763502_ChIP-Seq_THP-1_Human1.56926337
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55769840
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.55195815
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53757813
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52831107
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51459382
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.51212033
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51048995
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.50406114
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49812920
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49539860
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48585349
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48119658
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46491442
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44363915
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.43086470
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42515363
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42260611
61VDR_21846776_ChIP-Seq_THP-1_Human1.40467666
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40171528
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37690280
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34926190
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33864849
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33449712
67KDM5A_27292631_Chip-Seq_BREAST_Human1.33173372
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28455919
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28401701
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27590135
71ELK1_19687146_ChIP-ChIP_HELA_Human1.25363977
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.25186634
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23650759
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21597680
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20350236
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20220253
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19936520
78SPI1_23547873_ChIP-Seq_NB4_Human1.17753676
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14626641
80NCOR1_26117541_ChIP-Seq_K562_Human1.14244456
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11285688
82MAF_26560356_Chip-Seq_TH2_Human1.11277083
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09453258
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07977725
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06756832
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.05929690
87* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05789899
88SPI1_23127762_ChIP-Seq_K562_Human1.05606505
89TCF7_22412390_ChIP-Seq_EML_Mouse1.05598204
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.04962424
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02822581
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02762026
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01712334
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00543952
95MYC_18940864_ChIP-ChIP_HL60_Human0.99263998
96TFEB_21752829_ChIP-Seq_HELA_Human0.99193607
97SCL_19346495_ChIP-Seq_HPC-7_Human0.98970200
98MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98957684
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98615552
100ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98147895
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97987380
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97953156
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97313594
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95570301
105* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95521781
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94592547
107SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94514841
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94116760
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89347805
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88325507
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88049682
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85502611
113UTX_26944678_Chip-Seq_JUKART_Human0.85482623
114MYB_26560356_Chip-Seq_TH2_Human0.84231697
115MAF_26560356_Chip-Seq_TH1_Human0.82378466
116PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82089191
117MYB_26560356_Chip-Seq_TH1_Human0.81870240
118RUNX1_22412390_ChIP-Seq_EML_Mouse0.81833707
119ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81365511
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81273248
121* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80080722
122TP63_19390658_ChIP-ChIP_HaCaT_Human0.80037497
123SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79381678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.39309911
2MP0010094_abnormal_chromosome_stability4.62261878
3MP0003111_abnormal_nucleus_morphology4.25273039
4MP0004957_abnormal_blastocyst_morpholog3.99448308
5MP0003077_abnormal_cell_cycle3.78092902
6MP0008057_abnormal_DNA_replication3.74014201
7MP0008058_abnormal_DNA_repair3.12440560
8MP0002396_abnormal_hematopoietic_system2.97919613
9MP0008007_abnormal_cellular_replicative2.74128173
10MP0008260_abnormal_autophagy2.37740203
11MP0003303_peritoneal_inflammation2.32640016
12MP0008932_abnormal_embryonic_tissue2.27974477
13MP0000490_abnormal_crypts_of2.19686690
14MP0005397_hematopoietic_system_phenotyp2.12512190
15MP0001545_abnormal_hematopoietic_system2.12512190
16MP0010352_gastrointestinal_tract_polyps2.06542324
17MP0002419_abnormal_innate_immunity2.04479325
18MP0008877_abnormal_DNA_methylation2.03996588
19MP0001730_embryonic_growth_arrest2.00484700
20MP0003724_increased_susceptibility_to1.97537215
21MP0000350_abnormal_cell_proliferation1.97366168
22MP0003763_abnormal_thymus_physiology1.95620112
23MP0005058_abnormal_lysosome_morphology1.94877587
24MP0003806_abnormal_nucleotide_metabolis1.92104002
25MP0003786_premature_aging1.89439049
26MP0003191_abnormal_cellular_cholesterol1.89273890
27MP0004808_abnormal_hematopoietic_stem1.83380579
28MP0009333_abnormal_splenocyte_physiolog1.76615350
29MP0002019_abnormal_tumor_incidence1.73702036
30MP0003718_maternal_effect1.63745230
31MP0010307_abnormal_tumor_latency1.63353902
32MP0002398_abnormal_bone_marrow1.62581802
33MP0002148_abnormal_hypersensitivity_rea1.58843234
34MP0000313_abnormal_cell_death1.50047996
35MP0002722_abnormal_immune_system1.45914688
36MP0001790_abnormal_immune_system1.45437944
37MP0005387_immune_system_phenotype1.45437944
38MP0000689_abnormal_spleen_morphology1.45071629
39MP0001835_abnormal_antigen_presentation1.42958469
40MP0001929_abnormal_gametogenesis1.42188242
41MP0001697_abnormal_embryo_size1.41801896
42MP0002210_abnormal_sex_determination1.41202872
43MP0003123_paternal_imprinting1.40976360
44MP0003172_abnormal_lysosome_physiology1.38104519
45MP0000703_abnormal_thymus_morphology1.37721051
46MP0006082_CNS_inflammation1.37134944
47MP0002080_prenatal_lethality1.35900127
48MP0003656_abnormal_erythrocyte_physiolo1.35362939
49MP0000685_abnormal_immune_system1.35299346
50MP0005380_embryogenesis_phenotype1.31693028
51MP0001672_abnormal_embryogenesis/_devel1.31693028
52MP0006054_spinal_hemorrhage1.30499413
53MP0002429_abnormal_blood_cell1.26786095
54MP0005075_abnormal_melanosome_morpholog1.24752139
55MP0003300_gastrointestinal_ulcer1.24297365
56MP0001145_abnormal_male_reproductive1.23055666
57MP0003186_abnormal_redox_activity1.21852882
58MP0003984_embryonic_growth_retardation1.17435323
59MP0005076_abnormal_cell_differentiation1.17108703
60MP0000716_abnormal_immune_system1.16921310
61MP0002132_abnormal_respiratory_system1.15007510
62MP0000653_abnormal_sex_gland1.13250962
63MP0002088_abnormal_embryonic_growth/wei1.13149360
64MP0003183_abnormal_peptide_metabolism1.12653641
65MP0001845_abnormal_inflammatory_respons1.11106676
66MP0004147_increased_porphyrin_level1.11012007
67MP0002877_abnormal_melanocyte_morpholog1.10686054
68MP0002009_preneoplasia1.10642008
69MP0002086_abnormal_extraembryonic_tissu1.10618911
70MP0000858_altered_metastatic_potential1.10571532
71MP0008469_abnormal_protein_level1.10189295
72MP0004185_abnormal_adipocyte_glucose1.09899975
73MP0005671_abnormal_response_to1.08753415
74MP0001800_abnormal_humoral_immune1.08633332
75MP0006036_abnormal_mitochondrial_physio1.08224923
76MP0001853_heart_inflammation1.08141066
77MP0003567_abnormal_fetal_cardiomyocyte1.07661465
78MP0002085_abnormal_embryonic_tissue1.06208253
79MP0002420_abnormal_adaptive_immunity1.03970922
80MP0009278_abnormal_bone_marrow1.03602045
81MP0009785_altered_susceptibility_to1.02071123
82MP0001819_abnormal_immune_cell1.01990727
83MP0001119_abnormal_female_reproductive1.01706436
84MP0005174_abnormal_tail_pigmentation1.00353253
85MP0002166_altered_tumor_susceptibility0.98656430
86MP0009697_abnormal_copulation0.96892342
87MP0002452_abnormal_antigen_presenting0.95157674
88MP0001533_abnormal_skeleton_physiology0.94925183
89MP0003221_abnormal_cardiomyocyte_apopto0.94526063
90MP0005025_abnormal_response_to0.94383748
91MP0000465_gastrointestinal_hemorrhage0.94327406
92MP0002160_abnormal_reproductive_system0.93508422
93MP0005410_abnormal_fertilization0.92017275
94MP0004947_skin_inflammation0.90675668
95MP0002723_abnormal_immune_serum0.90641133
96MP0000358_abnormal_cell_content/0.90625412
97MP0005464_abnormal_platelet_physiology0.90457620
98MP0002084_abnormal_developmental_patter0.89981185
99MP0003828_pulmonary_edema0.89804215
100MP0005319_abnormal_enzyme/_coenzyme0.89148902
101MP0002006_tumorigenesis0.88663376
102MP0001873_stomach_inflammation0.88542433
103MP0002405_respiratory_system_inflammati0.88301752
104MP0009840_abnormal_foam_cell0.87059631
105MP0010155_abnormal_intestine_physiology0.85112074
106MP0003436_decreased_susceptibility_to0.82869046
107MP0000609_abnormal_liver_physiology0.81638206
108MP0002139_abnormal_hepatobiliary_system0.81633561
109MP0004381_abnormal_hair_follicle0.80816439
110MP0000477_abnormal_intestine_morphology0.80599408
111MP0001849_ear_inflammation0.80179635
112MP0002095_abnormal_skin_pigmentation0.79954485
113MP0004197_abnormal_fetal_growth/weight/0.79707468
114MP0003698_abnormal_male_reproductive0.75705609
115MP0005501_abnormal_skin_physiology0.75272143
116MP0001915_intracranial_hemorrhage0.74660321
117MP0003699_abnormal_female_reproductive0.70199962
118MP0009379_abnormal_foot_pigmentation0.70152710
119MP0005384_cellular_phenotype0.69870887
120MP0001764_abnormal_homeostasis0.69716907
121MP0005000_abnormal_immune_tolerance0.68583980
122MP0000598_abnormal_liver_morphology0.68140783
123MP0002161_abnormal_fertility/fecundity0.67776865
124MP0005621_abnormal_cell_physiology0.67640628
125MP0005389_reproductive_system_phenotype0.67589984
126MP0003866_abnormal_defecation0.67471574
127MP0005023_abnormal_wound_healing0.66996823
128MP0003315_abnormal_perineum_morphology0.65886070
129MP0006035_abnormal_mitochondrial_morpho0.62950323
130MP0005451_abnormal_body_composition0.62413414
131MP0005266_abnormal_metabolism0.62150659

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.16674205
2Abnormal number of erythroid precursors (HP:0012131)5.15044140
3Birth length less than 3rd percentile (HP:0003561)5.14105169
4Reticulocytopenia (HP:0001896)4.43221727
5Aplastic anemia (HP:0001915)4.13281581
6Recurrent abscess formation (HP:0002722)4.08515240
7Eczematoid dermatitis (HP:0000976)3.91147681
8Recurrent bacterial skin infections (HP:0005406)3.89469370
9Oral leukoplakia (HP:0002745)3.70657870
10Chromsome breakage (HP:0040012)3.65603642
11Breast hypoplasia (HP:0003187)3.65201247
12Thrombocytosis (HP:0001894)3.58079758
13Abnormality of macrophages (HP:0004311)3.48968643
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35534561
15Chronic obstructive pulmonary disease (HP:0006510)3.34789989
16Obstructive lung disease (HP:0006536)3.34789989
17Microvesicular hepatic steatosis (HP:0001414)3.12655301
18Abnormality of chromosome stability (HP:0003220)3.08982275
19Selective tooth agenesis (HP:0001592)3.02362836
20Recurrent gram-negative bacterial infections (HP:0005420)3.02317248
21Colon cancer (HP:0003003)2.99536795
22Microretrognathia (HP:0000308)2.98329973
23Pallor (HP:0000980)2.96465993
24Carpal bone hypoplasia (HP:0001498)2.94768093
25Absent thumb (HP:0009777)2.94683238
26Myelodysplasia (HP:0002863)2.94077875
27Abnormality of the preputium (HP:0100587)2.92480078
28Abnormality of the heme biosynthetic pathway (HP:0010472)2.89005432
29Myositis (HP:0100614)2.87005629
30Macrocytic anemia (HP:0001972)2.85230924
31Patellar aplasia (HP:0006443)2.82698492
32Meckel diverticulum (HP:0002245)2.82310475
33IgM deficiency (HP:0002850)2.77732172
34Abnormal gallbladder physiology (HP:0012438)2.76337829
35Cholecystitis (HP:0001082)2.76337829
36Abnormality of the anterior horn cell (HP:0006802)2.75002230
37Degeneration of anterior horn cells (HP:0002398)2.75002230
38Hepatosplenomegaly (HP:0001433)2.74127618
39Abnormality of the ileum (HP:0001549)2.72377691
40Recurrent viral infections (HP:0004429)2.69713236
41Meningitis (HP:0001287)2.69529198
42Cellulitis (HP:0100658)2.68320731
43Bone marrow hypocellularity (HP:0005528)2.63361828
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.62713677
45Aplasia/Hypoplasia of the patella (HP:0006498)2.58526097
46Rough bone trabeculation (HP:0100670)2.55543982
47Recurrent skin infections (HP:0001581)2.55201567
48Type I transferrin isoform profile (HP:0003642)2.54379812
49Recurrent fungal infections (HP:0002841)2.53331379
50Mediastinal lymphadenopathy (HP:0100721)2.52166900
5111 pairs of ribs (HP:0000878)2.49031879
52Orchitis (HP:0100796)2.46218717
53Medulloblastoma (HP:0002885)2.45543476
54Pancytopenia (HP:0001876)2.45541557
55Basal cell carcinoma (HP:0002671)2.45077301
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42132542
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42132542
58Poikiloderma (HP:0001029)2.41403183
59Small intestinal stenosis (HP:0012848)2.40842320
60Duodenal stenosis (HP:0100867)2.40842320
61Ragged-red muscle fibers (HP:0003200)2.39079407
62Impulsivity (HP:0100710)2.38620865
63Multiple enchondromatosis (HP:0005701)2.36858609
64Abnormal spermatogenesis (HP:0008669)2.34691370
65Urticaria (HP:0001025)2.34555339
66Gastrointestinal inflammation (HP:0004386)2.34286221
67Panhypogammaglobulinemia (HP:0003139)2.33293757
68Reduced antithrombin III activity (HP:0001976)2.31622478
69Abnormality of pyrimidine metabolism (HP:0004353)2.29662879
70Agnosia (HP:0010524)2.28943536
71Premature graying of hair (HP:0002216)2.27281713
72Sloping forehead (HP:0000340)2.26442454
73Increased IgM level (HP:0003496)2.25654185
74Petechiae (HP:0000967)2.24936580
75Abnormality of T cell physiology (HP:0011840)2.23466059
76Gastrointestinal infarctions (HP:0005244)2.23143430
77Rhabdomyosarcoma (HP:0002859)2.22370655
78Lymphoma (HP:0002665)2.20872878
79Progressive external ophthalmoplegia (HP:0000590)2.20546432
80Encephalitis (HP:0002383)2.20048083
81Neoplasm of the pancreas (HP:0002894)2.19931525
82Inflammation of the large intestine (HP:0002037)2.19266452
83Muscle fiber atrophy (HP:0100295)2.18936052
84Squamous cell carcinoma (HP:0002860)2.18412632
85Abnormal delayed hypersensitivity skin test (HP:0002963)2.17592003
86Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17417699
87Colitis (HP:0002583)2.17350604
88Premature ovarian failure (HP:0008209)2.13780817
89Increased serum ferritin (HP:0003281)2.12864788
90Abnormality of DNA repair (HP:0003254)2.12836053
91Abnormality of reticulocytes (HP:0004312)2.12780815
92Ependymoma (HP:0002888)2.11575293
93Cellular immunodeficiency (HP:0005374)2.10140326
94Retrobulbar optic neuritis (HP:0100654)2.08654320
95Optic neuritis (HP:0100653)2.08654320
96Prolonged bleeding time (HP:0003010)2.07788772
97Gingivitis (HP:0000230)2.07264759
98Recurrent cutaneous fungal infections (HP:0011370)2.07189721
99Chronic mucocutaneous candidiasis (HP:0002728)2.07189721
100Osteomyelitis (HP:0002754)2.05680965
101Stomatitis (HP:0010280)2.05576450
102Increased IgE level (HP:0003212)2.04391173
103Type 2 muscle fiber atrophy (HP:0003554)2.03978851
104Amaurosis fugax (HP:0100576)2.03705456
105Acute hepatic failure (HP:0006554)2.03626275
106Abnormality of the carotid arteries (HP:0005344)2.03339220
107Aplasia/Hypoplasia of the thymus (HP:0010515)2.02804125
108Pulmonary fibrosis (HP:0002206)2.01717431
109Prominent nose (HP:0000448)2.01673109
110Clubbing of toes (HP:0100760)2.00626083
111Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99732666
112Granulocytopenia (HP:0001913)1.99300895
113Abnormal protein glycosylation (HP:0012346)1.99275737
114Abnormal glycosylation (HP:0012345)1.99275737
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99275737
116Abnormal protein N-linked glycosylation (HP:0012347)1.99275737
117Hypertensive crisis (HP:0100735)1.98927500
118Recurrent bronchitis (HP:0002837)1.97921134
119Slender long bone (HP:0003100)1.97756221
120Loss of speech (HP:0002371)1.97014644
121Nasal polyposis (HP:0100582)1.95136994
122Abnormality of the duodenum (HP:0002246)1.94891298
123Abnormality of T cells (HP:0002843)1.94512084
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93522124
125Tracheoesophageal fistula (HP:0002575)1.93282491
126High pitched voice (HP:0001620)1.93235963
127Entropion (HP:0000621)1.92551657
128Thoracic kyphosis (HP:0002942)1.91963931
129Trismus (HP:0000211)1.91777066
130Elevated erythrocyte sedimentation rate (HP:0003565)1.91471623
131Progressive muscle weakness (HP:0003323)1.90410540
132Abnormality of the prostate (HP:0008775)1.90348519
133Vasculitis (HP:0002633)1.90271357
134Cerebral hypomyelination (HP:0006808)1.89460844
135Exertional dyspnea (HP:0002875)1.89218372
136Secondary amenorrhea (HP:0000869)1.88974893
137Poor head control (HP:0002421)1.88531057
138Cleft eyelid (HP:0000625)1.87877475
139Epistaxis (HP:0000421)1.86810804
140Polycythemia (HP:0001901)1.86362201
141Abnormality of glycolysis (HP:0004366)1.85635901
142Abnormality of glycolipid metabolism (HP:0010969)1.85589279
143Abnormality of liposaccharide metabolism (HP:0010968)1.85589279
144Abnormality of glycosphingolipid metabolism (HP:0004343)1.85589279
145Abnormal number of incisors (HP:0011064)1.84656567
146Purpura (HP:0000979)1.84043116
147Arterial thrombosis (HP:0004420)1.83324366
148Viral hepatitis (HP:0006562)1.82780970
149Increased cerebral lipofuscin (HP:0011813)1.82143695
150Increased serum pyruvate (HP:0003542)1.81927359
151Pustule (HP:0200039)1.81328443
152Anorexia (HP:0002039)1.81201042
153Chest pain (HP:0100749)1.81182507
154Acute myeloid leukemia (HP:0004808)1.81172314
155Triphalangeal thumb (HP:0001199)1.80966155
156Autoimmune hemolytic anemia (HP:0001890)1.80818085
157Polygenic inheritance (HP:0010982)1.80319567
158Abnormality of iron homeostasis (HP:0011031)1.80051583
159Increased serum lactate (HP:0002151)1.78841231
160Agammaglobulinemia (HP:0004432)1.78794270
161Fatigue (HP:0012378)1.78765737
162Abnormal lung lobation (HP:0002101)1.77421428
163Horseshoe kidney (HP:0000085)1.75869172
164Ectopic kidney (HP:0000086)1.75649494
165Amyloidosis (HP:0011034)1.75647876
166Chronic otitis media (HP:0000389)1.74969365
167Keratoconjunctivitis sicca (HP:0001097)1.74402650
168Nephroblastoma (Wilms tumor) (HP:0002667)1.73414676
169Abnormal trabecular bone morphology (HP:0100671)1.73031353
170Abnormality of the nasal mucosa (HP:0000433)1.72526659
171Skin rash (HP:0000988)1.69452714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.29896362
2CDC74.18094579
3BUB14.08272434
4NEK22.89032500
5EIF2AK12.81056243
6SMG12.73665876
7VRK22.63624901
8RIPK42.56312562
9ACVR1B2.43881606
10NME22.43680091
11STK162.34288501
12TTK2.21928751
13BRSK22.11100034
14ERN12.11055433
15PLK41.97383745
16PRPF4B1.96352282
17EEF2K1.91575691
18SRPK11.91425724
19VRK11.90977362
20MAP4K11.86828998
21PLK11.82922076
22TESK21.81983507
23CDK71.77577410
24EIF2AK31.71175163
25ATR1.65757467
26BLK1.64292859
27DYRK31.58183702
28RPS6KB21.54841825
29AURKB1.52833069
30NEK11.49508699
31RPS6KA41.49447748
32SCYL21.47286546
33STK101.46617171
34CDK41.41752323
35KDR1.41260691
36PIM21.40018117
37CHEK21.39560234
38BRSK11.35029125
39CDK81.33563281
40PBK1.33487779
41FES1.32742520
42IRAK31.31300442
43MAP3K81.30908151
44CCNB11.27849047
45PASK1.26299030
46TSSK61.24519692
47FGR1.21500059
48TAF11.18316163
49MAP3K141.17997325
50CSK1.17357125
51MAP3K111.15174581
52MAP2K31.15112383
53AURKA1.11864755
54MAP3K101.10647883
55FLT31.08599547
56TLK11.08483445
57TGFBR11.07868978
58MAPKAPK31.06331285
59PIM11.05000198
60PAK41.04129403
61STK41.02845559
62KSR20.96507214
63KIT0.96303219
64TESK10.91409492
65CHEK10.91151627
66TNK20.91030261
67BTK0.90820361
68MAP3K130.89993304
69BCKDK0.88198837
70LRRK20.86733623
71PKN20.86022590
72YES10.84677042
73BRAF0.83946867
74TEC0.83905121
75MKNK10.83452755
76PLK30.83417644
77SYK0.83282840
78HCK0.81123050
79MAP3K30.80775515
80MAP3K10.76051497
81ZAP700.73822097
82BMPR20.73200828
83MARK30.72730007
84ALK0.72393019
85CDK120.70613237
86MOS0.69838623
87JAK20.69786643
88IRAK20.69416889
89TAOK30.69071274
90MAP3K60.68188083
91ATM0.67587192
92GRK60.64715277
93PDK40.63955839
94PDK30.63955839
95CDK20.63326591
96JAK30.62131772
97PAK10.61431422
98CSF1R0.61313959
99STK240.61137547
100RAF10.60065024
101NEK90.59128101
102CSNK2A10.58161601
103MAPK110.58137415
104PTK60.57660603
105FGFR40.57398493
106ZAK0.57104813
107TYK20.55813270
108CSNK2A20.55788511
109CDK60.54017891
110MATK0.53341279
111NLK0.52740702
112TAOK10.51968977
113CLK10.50989089
114MKNK20.49254785
115CDK90.46408504
116IKBKE0.45263377
117EIF2AK20.42272680
118TBK10.39310064
119ILK0.38429278
120MELK0.38112825
121DAPK10.37975769
122CDK10.37801748
123TRIB30.35673472
124LYN0.33875403
125STK30.32704452
126ABL20.32629582
127TAOK20.31786241
128IRAK40.31623218
129RPS6KA50.31181340
130CDK190.30911496
131ARAF0.30259236
132PRKCI0.30180728

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.73233346
2Mismatch repair_Homo sapiens_hsa034304.49462921
3Ribosome_Homo sapiens_hsa030103.45832457
4Base excision repair_Homo sapiens_hsa034103.39544502
5Homologous recombination_Homo sapiens_hsa034403.25695404
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03695369
7Nucleotide excision repair_Homo sapiens_hsa034202.97695025
8Proteasome_Homo sapiens_hsa030502.88774281
9Spliceosome_Homo sapiens_hsa030402.82228279
10RNA polymerase_Homo sapiens_hsa030202.76753609
11Cell cycle_Homo sapiens_hsa041102.70969391
12Pyrimidine metabolism_Homo sapiens_hsa002402.64067700
13RNA transport_Homo sapiens_hsa030132.61436074
14One carbon pool by folate_Homo sapiens_hsa006702.35802475
15Fanconi anemia pathway_Homo sapiens_hsa034602.24484868
16Non-homologous end-joining_Homo sapiens_hsa034502.01928882
17RNA degradation_Homo sapiens_hsa030181.89167746
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88574844
19Basal transcription factors_Homo sapiens_hsa030221.87000642
20Staphylococcus aureus infection_Homo sapiens_hsa051501.67616884
21p53 signaling pathway_Homo sapiens_hsa041151.51039517
22Osteoclast differentiation_Homo sapiens_hsa043801.37673060
23Purine metabolism_Homo sapiens_hsa002301.35346530
24mRNA surveillance pathway_Homo sapiens_hsa030151.28740991
25Folate biosynthesis_Homo sapiens_hsa007901.25688914
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25286607
27Pentose phosphate pathway_Homo sapiens_hsa000301.23792555
28Allograft rejection_Homo sapiens_hsa053301.20964383
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.11112696
30Sulfur relay system_Homo sapiens_hsa041221.06090881
31Tuberculosis_Homo sapiens_hsa051521.05626121
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.05616498
33Antigen processing and presentation_Homo sapiens_hsa046121.04769350
34Asthma_Homo sapiens_hsa053101.02607214
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02434280
36Autoimmune thyroid disease_Homo sapiens_hsa053201.02376081
37Herpes simplex infection_Homo sapiens_hsa051681.01598611
38Non-small cell lung cancer_Homo sapiens_hsa052230.99496112
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97853027
40Epstein-Barr virus infection_Homo sapiens_hsa051690.97421542
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96954963
42Selenocompound metabolism_Homo sapiens_hsa004500.95977002
43Primary immunodeficiency_Homo sapiens_hsa053400.93821168
44Graft-versus-host disease_Homo sapiens_hsa053320.92877524
45Systemic lupus erythematosus_Homo sapiens_hsa053220.91411270
46Biosynthesis of amino acids_Homo sapiens_hsa012300.90497506
47Vitamin B6 metabolism_Homo sapiens_hsa007500.82497558
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79567047
49Oocyte meiosis_Homo sapiens_hsa041140.78827642
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.76635940
51Fatty acid elongation_Homo sapiens_hsa000620.74949115
52N-Glycan biosynthesis_Homo sapiens_hsa005100.73004196
53Viral carcinogenesis_Homo sapiens_hsa052030.71043597
54Viral myocarditis_Homo sapiens_hsa054160.70941617
55Glutathione metabolism_Homo sapiens_hsa004800.70702723
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70577026
57Malaria_Homo sapiens_hsa051440.68825489
58Protein export_Homo sapiens_hsa030600.68547749
59Thyroid cancer_Homo sapiens_hsa052160.68320917
60Toxoplasmosis_Homo sapiens_hsa051450.65658509
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64677289
62Lysosome_Homo sapiens_hsa041420.60936929
63HTLV-I infection_Homo sapiens_hsa051660.60096607
64Type I diabetes mellitus_Homo sapiens_hsa049400.58892517
65Carbon metabolism_Homo sapiens_hsa012000.57474009
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56681331
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54636507
68Measles_Homo sapiens_hsa051620.53155133
69Legionellosis_Homo sapiens_hsa051340.53062183
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.52547361
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51770020
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48921969
73Pertussis_Homo sapiens_hsa051330.48085353
74HIF-1 signaling pathway_Homo sapiens_hsa040660.47587447
75Apoptosis_Homo sapiens_hsa042100.46601942
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46506285
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45565637
78Shigellosis_Homo sapiens_hsa051310.44486689
79T cell receptor signaling pathway_Homo sapiens_hsa046600.44180372
80Phagosome_Homo sapiens_hsa041450.43898026
81Small cell lung cancer_Homo sapiens_hsa052220.43773877
82Huntingtons disease_Homo sapiens_hsa050160.43094388
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43061310
84Hepatitis C_Homo sapiens_hsa051600.42691443
85Salmonella infection_Homo sapiens_hsa051320.41862537
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38480237
87Hepatitis B_Homo sapiens_hsa051610.38346172
88Fructose and mannose metabolism_Homo sapiens_hsa000510.37458811
89Galactose metabolism_Homo sapiens_hsa000520.36902733
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34823032
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34647492
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34196136
93Acute myeloid leukemia_Homo sapiens_hsa052210.33893849
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33254648
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.32964379
96Other glycan degradation_Homo sapiens_hsa005110.32756878
97Hematopoietic cell lineage_Homo sapiens_hsa046400.32733407
98Influenza A_Homo sapiens_hsa051640.32131785
99Metabolic pathways_Homo sapiens_hsa011000.30461425
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.29885367
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26576200
102Colorectal cancer_Homo sapiens_hsa052100.25204480
103B cell receptor signaling pathway_Homo sapiens_hsa046620.24657867
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23995812
105Pyruvate metabolism_Homo sapiens_hsa006200.23828104
106MicroRNAs in cancer_Homo sapiens_hsa052060.23613638
107Chronic myeloid leukemia_Homo sapiens_hsa052200.21619683
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21348167
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18303117
110Leishmaniasis_Homo sapiens_hsa051400.17716004
111Caffeine metabolism_Homo sapiens_hsa002320.16823048
112Parkinsons disease_Homo sapiens_hsa050120.16548566
113Bladder cancer_Homo sapiens_hsa052190.15694811
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15084988
115Pancreatic cancer_Homo sapiens_hsa052120.14528111
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14171981
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.13846933
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.13396139
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12884351
120Renin-angiotensin system_Homo sapiens_hsa046140.11804695
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10769473
122Alcoholism_Homo sapiens_hsa050340.10376758
123Arachidonic acid metabolism_Homo sapiens_hsa005900.09805497
124Notch signaling pathway_Homo sapiens_hsa043300.08475664

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