HAUS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1meiotic chromosome segregation (GO:0045132)5.03513214
2CENP-A containing nucleosome assembly (GO:0034080)4.97326346
3chromatin remodeling at centromere (GO:0031055)4.86125324
4mitotic metaphase plate congression (GO:0007080)4.85357653
5DNA strand elongation involved in DNA replication (GO:0006271)4.82793674
6kinetochore organization (GO:0051383)4.80485969
7attachment of spindle microtubules to kinetochore (GO:0008608)4.75235763
8telomere maintenance via semi-conservative replication (GO:0032201)4.67327313
9DNA strand elongation (GO:0022616)4.63339375
10metaphase plate congression (GO:0051310)4.62178654
11DNA replication checkpoint (GO:0000076)4.62017984
12protein localization to kinetochore (GO:0034501)4.58786793
13DNA replication-independent nucleosome assembly (GO:0006336)4.48574511
14DNA replication-independent nucleosome organization (GO:0034724)4.48574511
15DNA replication initiation (GO:0006270)4.44012482
16telomere maintenance via recombination (GO:0000722)4.38105098
17mitotic recombination (GO:0006312)4.25401340
18mitotic chromosome condensation (GO:0007076)4.20232415
19purine nucleobase biosynthetic process (GO:0009113)4.19422632
20establishment of chromosome localization (GO:0051303)4.16100637
21histone exchange (GO:0043486)4.11503094
22nucleobase biosynthetic process (GO:0046112)4.11291747
23kinetochore assembly (GO:0051382)4.09550861
24protein localization to chromosome, centromeric region (GO:0071459)4.08829080
25protein K11-linked deubiquitination (GO:0035871)4.05562002
26DNA unwinding involved in DNA replication (GO:0006268)3.98916219
27ribosomal small subunit assembly (GO:0000028)3.94781033
28DNA replication-dependent nucleosome assembly (GO:0006335)3.88458794
29DNA replication-dependent nucleosome organization (GO:0034723)3.88458794
30mitotic sister chromatid segregation (GO:0000070)3.80618737
31maturation of SSU-rRNA (GO:0030490)3.79621758
32telomere maintenance via telomere lengthening (GO:0010833)3.76024093
33regulation of spindle organization (GO:0090224)3.73858244
34piRNA metabolic process (GO:0034587)3.66470349
35regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.66331471
36regulation of mitotic spindle checkpoint (GO:1903504)3.66331471
37nuclear pore organization (GO:0006999)3.65542429
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61843751
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.58469850
40recombinational repair (GO:0000725)3.56599773
41neural tube formation (GO:0001841)3.55362276
42mitotic nuclear envelope disassembly (GO:0007077)3.55093664
43behavioral response to nicotine (GO:0035095)3.54328612
44double-strand break repair via homologous recombination (GO:0000724)3.52456007
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.51172605
46sister chromatid segregation (GO:0000819)3.50736157
47maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.48573526
48regulation of double-strand break repair via homologous recombination (GO:0010569)3.41832515
49mitotic sister chromatid cohesion (GO:0007064)3.41813697
50centriole replication (GO:0007099)3.35663129
51postreplication repair (GO:0006301)3.34722944
52spindle checkpoint (GO:0031577)3.32284532
53nuclear pore complex assembly (GO:0051292)3.31551212
54tachykinin receptor signaling pathway (GO:0007217)3.30738140
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30574763
56chromatin assembly or disassembly (GO:0006333)3.29145895
57DNA double-strand break processing (GO:0000729)3.29036898
58rRNA catabolic process (GO:0016075)3.28273854
59membrane disassembly (GO:0030397)3.27227137
60nuclear envelope disassembly (GO:0051081)3.27227137
61chromosome segregation (GO:0007059)3.27193634
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.26576493
63telomere organization (GO:0032200)3.24317841
64mismatch repair (GO:0006298)3.23513001
65telomere maintenance (GO:0000723)3.22676041
66somatic diversification of immune receptors via somatic mutation (GO:0002566)3.21949124
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.21949124
68positive regulation of chromosome segregation (GO:0051984)3.20365374
69replication fork processing (GO:0031297)3.19026337
70DNA deamination (GO:0045006)3.18313772
71DNA ligation (GO:0006266)3.17830785
72regulation of chromosome segregation (GO:0051983)3.17297043
73regulation of mitotic spindle organization (GO:0060236)3.16489128
74response to pheromone (GO:0019236)3.15037441
75spindle assembly checkpoint (GO:0071173)3.14604152
76negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14292137
77negative regulation of sister chromatid segregation (GO:0033046)3.14292137
78negative regulation of mitotic sister chromatid separation (GO:2000816)3.14292137
79negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14292137
80regulation of nuclear cell cycle DNA replication (GO:0033262)3.14143372
81synapsis (GO:0007129)3.13767041
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13397703
83negative regulation of chromosome segregation (GO:0051985)3.11835409
84somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.11636496
85isotype switching (GO:0045190)3.11636496
86somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.11636496
87protein localization to chromosome (GO:0034502)3.10580911
88regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10325582
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10290144
90protein K6-linked ubiquitination (GO:0085020)3.10083473
91ATP-dependent chromatin remodeling (GO:0043044)3.07711992
92ribosome biogenesis (GO:0042254)3.06825772
93proteasome assembly (GO:0043248)3.06430814
94fucose catabolic process (GO:0019317)3.06260145
95L-fucose metabolic process (GO:0042354)3.06260145
96L-fucose catabolic process (GO:0042355)3.06260145
97mitotic spindle assembly checkpoint (GO:0007094)3.06080177
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04596596
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04596596
100regulation of centrosome cycle (GO:0046605)3.03748689
101transcription-coupled nucleotide-excision repair (GO:0006283)3.03022758
102IMP biosynthetic process (GO:0006188)3.02771232
103mitotic spindle checkpoint (GO:0071174)3.00145697
104DNA topological change (GO:0006265)2.99958044
105ribonucleoprotein complex biogenesis (GO:0022613)2.99451607
106regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99166876
107ribosomal large subunit biogenesis (GO:0042273)2.98743600
108regulation of DNA endoreduplication (GO:0032875)2.97780596
109preassembly of GPI anchor in ER membrane (GO:0016254)2.97302108
110ribosome assembly (GO:0042255)2.97071761
111regulation of sister chromatid segregation (GO:0033045)2.96755401
112regulation of mitotic sister chromatid separation (GO:0010965)2.96755401
113regulation of mitotic sister chromatid segregation (GO:0033047)2.96755401
114protein K63-linked deubiquitination (GO:0070536)2.95967508
115formation of translation preinitiation complex (GO:0001731)2.95918179
116regulation of meiosis I (GO:0060631)2.94552532
117reciprocal DNA recombination (GO:0035825)2.93724869
118reciprocal meiotic recombination (GO:0007131)2.93724869
119G1/S transition of mitotic cell cycle (GO:0000082)2.93377136
120cell cycle G1/S phase transition (GO:0044843)2.93377136
121regulation of centriole replication (GO:0046599)2.91853281
122resolution of meiotic recombination intermediates (GO:0000712)2.91139744
123ribosomal small subunit biogenesis (GO:0042274)2.90903243
124rRNA processing (GO:0006364)2.90248221
125translesion synthesis (GO:0019985)2.88576160
126IMP metabolic process (GO:0046040)2.88130222
127mitotic cell cycle (GO:0000278)2.87829161
128viral mRNA export from host cell nucleus (GO:0046784)2.84666955
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83833904
130positive regulation of mitotic sister chromatid separation (GO:1901970)2.83833904
131male meiosis I (GO:0007141)2.81099830
132exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75689002
133nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72200639
134negative regulation of DNA recombination (GO:0045910)2.69202809
135somatic diversification of immunoglobulins (GO:0016445)2.68601104
136interkinetic nuclear migration (GO:0022027)2.68130983
137negative regulation of telomere maintenance (GO:0032205)2.67896112
138histone H2A acetylation (GO:0043968)2.65825938
139organelle disassembly (GO:1903008)2.65510172
140maturation of 5.8S rRNA (GO:0000460)2.65403360
141DNA recombination (GO:0006310)2.62793521
142peptidyl-threonine dephosphorylation (GO:0035970)2.62641888
143monoubiquitinated protein deubiquitination (GO:0035520)2.61343316
144protein K48-linked deubiquitination (GO:0071108)2.59519778
145regulation of telomere maintenance (GO:0032204)2.59462404
146DNA methylation involved in gamete generation (GO:0043046)2.56919303
147somatic diversification of immune receptors (GO:0002200)2.56807048
148pseudouridine synthesis (GO:0001522)2.56276425
149protein prenylation (GO:0018342)2.54939922
150prenylation (GO:0097354)2.54939922
151establishment of protein localization to Golgi (GO:0072600)2.51272980
152positive regulation of defense response to virus by host (GO:0002230)2.51122218
153somatic recombination of immunoglobulin gene segments (GO:0016447)2.51099626
154DNA-dependent DNA replication (GO:0006261)2.50655616
155double-strand break repair (GO:0006302)2.49344042
156microtubule anchoring (GO:0034453)2.49128343
157kynurenine metabolic process (GO:0070189)2.46809508
158positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.46044446
159positive regulation of mRNA metabolic process (GO:1903313)2.44992238
160ubiquinone biosynthetic process (GO:0006744)2.44721129
161negative regulation by host of viral transcription (GO:0043922)2.44667153
162histone mRNA metabolic process (GO:0008334)2.43667492
163somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.43536861
164somatic cell DNA recombination (GO:0016444)2.43536861
165DNA demethylation (GO:0080111)2.42789613
166positive regulation of mRNA processing (GO:0050685)2.42532880
167DNA catabolic process, exonucleolytic (GO:0000738)2.41723755
168mitochondrial RNA metabolic process (GO:0000959)2.41533971
169positive regulation of histone H3-K4 methylation (GO:0051571)2.41148590
170gene silencing by RNA (GO:0031047)2.41098671
171tryptophan metabolic process (GO:0006568)2.40005295
172protein-cofactor linkage (GO:0018065)2.39451111
173indolalkylamine metabolic process (GO:0006586)2.38881993
174negative T cell selection (GO:0043383)2.38154593
175tryptophan catabolic process (GO:0006569)2.36909236
176indole-containing compound catabolic process (GO:0042436)2.36909236
177indolalkylamine catabolic process (GO:0046218)2.36909236
178S-adenosylmethionine metabolic process (GO:0046500)2.35823327
179positive regulation of oligodendrocyte differentiation (GO:0048714)2.35779583
180microtubule depolymerization (GO:0007019)2.35224585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.35770516
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.84382889
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.37801988
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.78119695
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.65751640
6ZNF274_21170338_ChIP-Seq_K562_Hela3.45114713
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34503918
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06809976
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.94555258
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.83258280
11VDR_22108803_ChIP-Seq_LS180_Human2.83009759
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.81556233
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68705987
14EWS_26573619_Chip-Seq_HEK293_Human2.62067521
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59233509
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53719201
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52999241
18AR_21909140_ChIP-Seq_LNCAP_Human2.46599730
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46285837
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.44547148
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44144717
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41820709
23VDR_23849224_ChIP-Seq_CD4+_Human2.40797974
24FUS_26573619_Chip-Seq_HEK293_Human2.37003246
25IGF1R_20145208_ChIP-Seq_DFB_Human2.36296734
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.27752563
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27734996
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27589333
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.24863357
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14934069
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10604816
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09571707
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07494244
34XRN2_22483619_ChIP-Seq_HELA_Human2.05543322
35FOXP3_21729870_ChIP-Seq_TREG_Human2.05055148
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04393713
37IRF1_19129219_ChIP-ChIP_H3396_Human2.04181357
38ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01969220
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99614651
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98079224
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97728604
42ELK1_19687146_ChIP-ChIP_HELA_Human1.94114031
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92507564
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86973686
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86673397
46TAF15_26573619_Chip-Seq_HEK293_Human1.86079274
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84082834
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83793033
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.83692722
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83677928
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81693652
52ER_23166858_ChIP-Seq_MCF-7_Human1.79759827
53DCP1A_22483619_ChIP-Seq_HELA_Human1.77642148
54GABP_19822575_ChIP-Seq_HepG2_Human1.69265701
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69246763
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66320290
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66167561
58P300_19829295_ChIP-Seq_ESCs_Human1.63419201
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61671167
60TTF2_22483619_ChIP-Seq_HELA_Human1.61242443
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61114765
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56772167
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56441577
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56416208
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53466200
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50503087
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50107862
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49153282
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48836340
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48099848
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48088719
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46569171
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46402458
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45153081
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44617033
76TP53_22573176_ChIP-Seq_HFKS_Human1.42265998
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.40679755
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39043811
79GBX2_23144817_ChIP-Seq_PC3_Human1.38949359
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38236440
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37322493
82KDM5A_27292631_Chip-Seq_BREAST_Human1.36124704
83CIITA_25753668_ChIP-Seq_RAJI_Human1.35716676
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35508999
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35001309
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32970871
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.31915824
88GATA3_26560356_Chip-Seq_TH2_Human1.28435213
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27534032
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27032879
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25259063
92* SPI1_23547873_ChIP-Seq_NB4_Human1.24871282
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22643650
94CBP_20019798_ChIP-Seq_JUKART_Human1.22289027
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22289027
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21251232
97STAT3_23295773_ChIP-Seq_U87_Human1.21163569
98MYC_22102868_ChIP-Seq_BL_Human1.21096001
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.19474479
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16878791
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16800951
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.16722854
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.15559478
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14734667
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13822070
106* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12573677
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12539796
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12115779
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.11120446
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11120446
111MYC_18940864_ChIP-ChIP_HL60_Human1.10828913
112* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08902701
113TFEB_21752829_ChIP-Seq_HELA_Human1.08273351
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06223275
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.04153981
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.03708490
117TCF4_23295773_ChIP-Seq_U87_Human1.03292876
118MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02987358
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02651620
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02456321
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.02287210
122SOX2_19829295_ChIP-Seq_ESCs_Human1.01680540
123NANOG_19829295_ChIP-Seq_ESCs_Human1.01680540
124BCAT_22108803_ChIP-Seq_LS180_Human0.98206283
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97505118
126RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95018241
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94170439
128KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93744749
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93168143
130CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92230393
131* GATA3_26560356_Chip-Seq_TH1_Human0.91776727
132SCL_19346495_ChIP-Seq_HPC-7_Human0.91345236
133GATA3_27048872_Chip-Seq_THYMUS_Human0.91007420
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90383790
135AR_20517297_ChIP-Seq_VCAP_Human0.89459163
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89450001
137SMAD4_21799915_ChIP-Seq_A2780_Human0.89276624
138RUNX_20019798_ChIP-Seq_JUKART_Human0.89102584
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.88982213
140AR_25329375_ChIP-Seq_VCAP_Human0.88706865
141SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88685454
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88222194
143CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85736403
144SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85501208
145MYB_26560356_Chip-Seq_TH2_Human0.85294440
146STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83763201
147IRF8_21731497_ChIP-ChIP_J774_Mouse0.83588549
148IRF8_22096565_ChIP-ChIP_GC-B_Human0.83170210
149MYB_26560356_Chip-Seq_TH1_Human0.79249566
150VDR_21846776_ChIP-Seq_THP-1_Human0.78416729
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75640994
152* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74552355
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73715340
154FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73704733
155STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72517222
156PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.70534166
157RUNX1_22412390_ChIP-Seq_EML_Mouse0.70367805
158CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.68844941
159FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.68674504
160SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68538504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.19220981
2MP0003693_abnormal_embryo_hatching5.04612921
3MP0008057_abnormal_DNA_replication4.36839256
4MP0003111_abnormal_nucleus_morphology4.15417532
5MP0004957_abnormal_blastocyst_morpholog4.10549435
6MP0003077_abnormal_cell_cycle3.93211959
7MP0008058_abnormal_DNA_repair3.79433874
8MP0002396_abnormal_hematopoietic_system3.38941214
9MP0008877_abnormal_DNA_methylation3.04200668
10MP0008007_abnormal_cellular_replicative3.03011148
11MP0008932_abnormal_embryonic_tissue2.51578738
12MP0003786_premature_aging2.35976824
13MP0003195_calcinosis2.22741752
14MP0010307_abnormal_tumor_latency2.16299711
15MP0002102_abnormal_ear_morphology2.12886175
16MP0004808_abnormal_hematopoietic_stem2.10401244
17MP0005645_abnormal_hypothalamus_physiol1.95147179
18MP0000350_abnormal_cell_proliferation1.94224582
19MP0006072_abnormal_retinal_apoptosis1.85458284
20MP0003763_abnormal_thymus_physiology1.84291294
21MP0000569_abnormal_digit_pigmentation1.83934800
22MP0001730_embryonic_growth_arrest1.80884267
23MP0000490_abnormal_crypts_of1.77247299
24MP0001545_abnormal_hematopoietic_system1.76996036
25MP0005397_hematopoietic_system_phenotyp1.76996036
26MP0001919_abnormal_reproductive_system1.72060939
27MP0002398_abnormal_bone_marrow1.64827425
28MP0002019_abnormal_tumor_incidence1.61274810
29MP0001968_abnormal_touch/_nociception1.60177154
30MP0001835_abnormal_antigen_presentation1.58955703
31MP0009333_abnormal_splenocyte_physiolog1.58435435
32MP0002210_abnormal_sex_determination1.58230569
33MP0003123_paternal_imprinting1.57092464
34MP0003787_abnormal_imprinting1.55567627
35MP0001986_abnormal_taste_sensitivity1.54119245
36MP0005253_abnormal_eye_physiology1.51527065
37MP0005551_abnormal_eye_electrophysiolog1.49962970
38MP0000313_abnormal_cell_death1.47951897
39MP0003718_maternal_effect1.46905716
40MP0010386_abnormal_urinary_bladder1.46811484
41MP0005084_abnormal_gallbladder_morpholo1.46321639
42MP0000703_abnormal_thymus_morphology1.45063662
43MP0000689_abnormal_spleen_morphology1.45018604
44MP0001501_abnormal_sleep_pattern1.44069520
45MP0003646_muscle_fatigue1.42492201
46MP0002736_abnormal_nociception_after1.42204618
47MP0000427_abnormal_hair_cycle1.41909710
48MP0002722_abnormal_immune_system1.41608097
49MP0004142_abnormal_muscle_tone1.41034967
50MP0000631_abnormal_neuroendocrine_gland1.40162567
51MP0005671_abnormal_response_to1.36903046
52MP0001697_abnormal_embryo_size1.36590628
53MP0004147_increased_porphyrin_level1.34613141
54MP0001929_abnormal_gametogenesis1.33096120
55MP0008872_abnormal_physiological_respon1.29264563
56MP0001145_abnormal_male_reproductive1.28697395
57MP0001672_abnormal_embryogenesis/_devel1.28627491
58MP0005380_embryogenesis_phenotype1.28627491
59MP0010352_gastrointestinal_tract_polyps1.28039198
60MP0002638_abnormal_pupillary_reflex1.27294574
61MP0001800_abnormal_humoral_immune1.26311108
62MP0002928_abnormal_bile_duct1.24819771
63MP0002006_tumorigenesis1.24645830
64MP0005646_abnormal_pituitary_gland1.23757294
65MP0000372_irregular_coat_pigmentation1.23715775
66MP0002166_altered_tumor_susceptibility1.23624947
67MP0000716_abnormal_immune_system1.22227702
68MP0006292_abnormal_olfactory_placode1.22019549
69MP0002429_abnormal_blood_cell1.21860903
70MP0000653_abnormal_sex_gland1.20965886
71MP0002080_prenatal_lethality1.20542687
72MP0006054_spinal_hemorrhage1.19041901
73MP0000685_abnormal_immune_system1.18125801
74MP0002420_abnormal_adaptive_immunity1.16180400
75MP0001119_abnormal_female_reproductive1.14973082
76MP0004742_abnormal_vestibular_system1.14826165
77MP0001819_abnormal_immune_cell1.14245594
78MP0003984_embryonic_growth_retardation1.12929384
79MP0004043_abnormal_pH_regulation1.12848223
80MP0003567_abnormal_fetal_cardiomyocyte1.11949524
81MP0000465_gastrointestinal_hemorrhage1.11731635
82MP0009697_abnormal_copulation1.08378288
83MP0002452_abnormal_antigen_presenting1.08258250
84MP0002009_preneoplasia1.07314723
85MP0002088_abnormal_embryonic_growth/wei1.07177647
86MP0002277_abnormal_respiratory_mucosa1.06725889
87MP0002095_abnormal_skin_pigmentation1.05162967
88MP0008961_abnormal_basal_metabolism1.04439117
89MP0002723_abnormal_immune_serum1.03958644
90MP0006035_abnormal_mitochondrial_morpho1.01495896
91MP0002086_abnormal_extraembryonic_tissu1.01106474
92MP0002085_abnormal_embryonic_tissue1.01074915
93MP0001853_heart_inflammation0.98382970
94MP0009785_altered_susceptibility_to0.97705117
95MP0002837_dystrophic_cardiac_calcinosis0.97543004
96MP0009745_abnormal_behavioral_response0.94177529
97MP0003011_delayed_dark_adaptation0.94090515
98MP0003186_abnormal_redox_activity0.90557245
99MP0005000_abnormal_immune_tolerance0.90325853
100MP0002876_abnormal_thyroid_physiology0.89950610
101MP0009046_muscle_twitch0.89673654
102MP0003121_genomic_imprinting0.88132838
103MP0004145_abnormal_muscle_electrophysio0.88017626
104MP0002084_abnormal_developmental_patter0.86589997
105MP0002163_abnormal_gland_morphology0.86211232
106MP0003806_abnormal_nucleotide_metabolis0.85094933
107MP0000647_abnormal_sebaceous_gland0.84345194
108MP0005464_abnormal_platelet_physiology0.83582764
109MP0005266_abnormal_metabolism0.83530584
110MP0005379_endocrine/exocrine_gland_phen0.83215451
111MP0001529_abnormal_vocalization0.82796647
112MP0002405_respiratory_system_inflammati0.82771147
113MP0005025_abnormal_response_to0.82433902
114MP0001764_abnormal_homeostasis0.82264967
115MP0005410_abnormal_fertilization0.81526340
116MP0004197_abnormal_fetal_growth/weight/0.80033844
117MP0003315_abnormal_perineum_morphology0.79788549
118MP0003724_increased_susceptibility_to0.77841544
119MP0000858_altered_metastatic_potential0.77731882
120MP0004885_abnormal_endolymph0.77396004
121MP0002751_abnormal_autonomic_nervous0.77117974
122MP0003890_abnormal_embryonic-extraembry0.76688396
123MP0001915_intracranial_hemorrhage0.75197932
124MP0005075_abnormal_melanosome_morpholog0.74566046
125MP0005310_abnormal_salivary_gland0.73448231
126MP0005384_cellular_phenotype0.73315532
127MP0005621_abnormal_cell_physiology0.72814642
128MP0006276_abnormal_autonomic_nervous0.72747711
129MP0002132_abnormal_respiratory_system0.72344464
130MP0005174_abnormal_tail_pigmentation0.72136790
131MP0000383_abnormal_hair_follicle0.71812980
132MP0003880_abnormal_central_pattern0.71748656
133MP0002148_abnormal_hypersensitivity_rea0.70874688
134MP0001293_anophthalmia0.70236815
135MP0009764_decreased_sensitivity_to0.69262640
136MP0000015_abnormal_ear_pigmentation0.69237877
137MP0002272_abnormal_nervous_system0.69122867
138MP0005389_reproductive_system_phenotype0.68938319
139MP0002067_abnormal_sensory_capabilities0.68524086
140MP0010155_abnormal_intestine_physiology0.68333124
141MP0003448_altered_tumor_morphology0.68120999
142MP0003943_abnormal_hepatobiliary_system0.66001850
143MP0006036_abnormal_mitochondrial_physio0.65972530
144MP0003699_abnormal_female_reproductive0.64845790
145MP0009379_abnormal_foot_pigmentation0.64496864
146MP0003656_abnormal_erythrocyte_physiolo0.64218424
147MP0002419_abnormal_innate_immunity0.63412990
148MP0008995_early_reproductive_senescence0.63225402
149MP0002160_abnormal_reproductive_system0.62454998
150MP0001873_stomach_inflammation0.62214962
151MP0005076_abnormal_cell_differentiation0.61755530
152MP0003698_abnormal_male_reproductive0.61570545

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.61343276
2Chromsome breakage (HP:0040012)5.12301891
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.65791386
4Aplastic anemia (HP:0001915)4.06470764
5Abnormality of chromosome stability (HP:0003220)3.96945343
6Reticulocytopenia (HP:0001896)3.85919688
7Pancreatic cysts (HP:0001737)3.81548946
8Abnormal number of erythroid precursors (HP:0012131)3.64030863
9Abnormality of cells of the erythroid lineage (HP:0012130)3.59193779
10Colon cancer (HP:0003003)3.58508709
11Breast hypoplasia (HP:0003187)3.56273276
12Congenital stationary night blindness (HP:0007642)3.48988724
13Pancreatic fibrosis (HP:0100732)3.38843010
14Abnormality of the preputium (HP:0100587)3.37774283
15Medulloblastoma (HP:0002885)3.36332355
16Meckel diverticulum (HP:0002245)3.33172090
17Abnormality of the ileum (HP:0001549)3.19119851
18Myelodysplasia (HP:0002863)3.16227881
19Molar tooth sign on MRI (HP:0002419)3.09314628
20Abnormality of midbrain morphology (HP:0002418)3.09314628
21Patellar aplasia (HP:0006443)3.06382257
22Aplasia/Hypoplasia of the uvula (HP:0010293)3.05789214
23True hermaphroditism (HP:0010459)3.00608363
24Oral leukoplakia (HP:0002745)3.00052629
25Duodenal stenosis (HP:0100867)2.92138344
26Small intestinal stenosis (HP:0012848)2.92138344
27Abnormality of the renal cortex (HP:0011035)2.88832728
28Agnosia (HP:0010524)2.88201323
29Stomach cancer (HP:0012126)2.85603060
30Aplasia/Hypoplasia of the patella (HP:0006498)2.81624305
31Chronic hepatic failure (HP:0100626)2.77730948
32Renal cortical cysts (HP:0000803)2.75805378
33Bone marrow hypocellularity (HP:0005528)2.75647221
34Type II lissencephaly (HP:0007260)2.75322449
35Rhabdomyosarcoma (HP:0002859)2.71782277
36Impulsivity (HP:0100710)2.71604820
37B lymphocytopenia (HP:0010976)2.69887595
38Abnormality of B cell number (HP:0010975)2.69887595
39Nephronophthisis (HP:0000090)2.69297800
40Volvulus (HP:0002580)2.67428663
41Abnormal spermatogenesis (HP:0008669)2.64842626
42IgM deficiency (HP:0002850)2.64643292
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63815657
44Abnormality of alanine metabolism (HP:0010916)2.63815657
45Hyperalaninemia (HP:0003348)2.63815657
46Panhypogammaglobulinemia (HP:0003139)2.57574776
47Lymphoma (HP:0002665)2.53204707
48Degeneration of anterior horn cells (HP:0002398)2.53031303
49Abnormality of the anterior horn cell (HP:0006802)2.53031303
50Carpal bone hypoplasia (HP:0001498)2.52611195
51Acute myeloid leukemia (HP:0004808)2.52193337
52Abnormal lung lobation (HP:0002101)2.51941114
53Thrombocytosis (HP:0001894)2.50863035
5411 pairs of ribs (HP:0000878)2.48413322
55Attenuation of retinal blood vessels (HP:0007843)2.47354834
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.46081622
57Ectopic kidney (HP:0000086)2.43653951
58Premature graying of hair (HP:0002216)2.43209067
59Amaurosis fugax (HP:0100576)2.43196895
60Selective tooth agenesis (HP:0001592)2.41547037
61Clubbing of toes (HP:0100760)2.39555908
62Sloping forehead (HP:0000340)2.39370337
63Abnormality of the pons (HP:0007361)2.37636771
64Microretrognathia (HP:0000308)2.37200128
65Absent thumb (HP:0009777)2.36934624
66Combined immunodeficiency (HP:0005387)2.36460168
67Abnormality of DNA repair (HP:0003254)2.36333511
68Abnormality of the renal medulla (HP:0100957)2.34859534
69Progressive inability to walk (HP:0002505)2.34766963
70Pancytopenia (HP:0001876)2.34339199
71Hyperventilation (HP:0002883)2.32500098
72Abnormality of the duodenum (HP:0002246)2.32007162
73Severe combined immunodeficiency (HP:0004430)2.30892703
74Pallor (HP:0000980)2.29382437
75Nephroblastoma (Wilms tumor) (HP:0002667)2.26884093
76Rough bone trabeculation (HP:0100670)2.26653660
77Medial flaring of the eyebrow (HP:0010747)2.26469633
78Fair hair (HP:0002286)2.26109021
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.25961532
80Genetic anticipation (HP:0003743)2.25798506
81Duplicated collecting system (HP:0000081)2.25468491
82IgG deficiency (HP:0004315)2.23262168
83Protruding tongue (HP:0010808)2.21378449
84Supernumerary spleens (HP:0009799)2.20656266
85Oligodactyly (hands) (HP:0001180)2.20505350
86Ependymoma (HP:0002888)2.19943136
87Abolished electroretinogram (ERG) (HP:0000550)2.18213362
88Abnormal biliary tract physiology (HP:0012439)2.16997772
89Bile duct proliferation (HP:0001408)2.16997772
90Inability to walk (HP:0002540)2.16367995
91Entropion (HP:0000621)2.15392998
92Macrocytic anemia (HP:0001972)2.14560377
93Abnormality of the heme biosynthetic pathway (HP:0010472)2.14298256
94Abnormality of the carotid arteries (HP:0005344)2.12386273
95Embryonal renal neoplasm (HP:0011794)2.11905572
96Absent radius (HP:0003974)2.10949816
97Thyroiditis (HP:0100646)2.10479825
98Cerebral hypomyelination (HP:0006808)2.09416301
99Abnormality of the renal collecting system (HP:0004742)2.09330204
100Cerebellar dysplasia (HP:0007033)2.08755500
101Aplasia/Hypoplasia of the thymus (HP:0010515)2.07259674
102Broad-based gait (HP:0002136)2.07243131
103Cellular immunodeficiency (HP:0005374)2.06394793
104Hypoplasia of the pons (HP:0012110)2.05990978
105T lymphocytopenia (HP:0005403)2.04918301
106Gaze-evoked nystagmus (HP:0000640)2.04047679
107Type 2 muscle fiber atrophy (HP:0003554)2.03570940
108Pendular nystagmus (HP:0012043)2.03226147
109Clumsiness (HP:0002312)2.02426539
110Lissencephaly (HP:0001339)2.01819635
111Short tibia (HP:0005736)2.01384563
112Sclerocornea (HP:0000647)2.00873548
113Neoplasm of the pancreas (HP:0002894)2.00594138
114Stomatitis (HP:0010280)2.00439556
115Squamous cell carcinoma (HP:0002860)2.00250989
116Cafe-au-lait spot (HP:0000957)1.98847190
117Basal cell carcinoma (HP:0002671)1.98431268
118Hypoplasia of the thymus (HP:0000778)1.97499132
119Abnormal rod and cone electroretinograms (HP:0008323)1.96376956
120Abnormality of the labia minora (HP:0012880)1.95531798
121Abnormality of the fingertips (HP:0001211)1.94934843
122Aplasia involving forearm bones (HP:0009822)1.93120552
123Absent forearm bone (HP:0003953)1.93120552
124Abnormality of T cell number (HP:0011839)1.93073435
125Petechiae (HP:0000967)1.92981683
126Cystic liver disease (HP:0006706)1.92860935
127Facial hemangioma (HP:0000329)1.91612279
128Recurrent viral infections (HP:0004429)1.91273159
129Increased nuchal translucency (HP:0010880)1.91149313
130Muscle fiber atrophy (HP:0100295)1.91053147
131Type I transferrin isoform profile (HP:0003642)1.89937298
132Slender long bone (HP:0003100)1.89764147
133Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88456688
134Abnormality of the prostate (HP:0008775)1.88346346
135Overlapping toe (HP:0001845)1.88218880
136Poikiloderma (HP:0001029)1.88180080
137Tracheoesophageal fistula (HP:0002575)1.87877252
138Triphalangeal thumb (HP:0001199)1.87461178
139Azoospermia (HP:0000027)1.86657458
140Abnormality of T cells (HP:0002843)1.86193987
141Prominent nose (HP:0000448)1.86048280
142Lipid accumulation in hepatocytes (HP:0006561)1.85799848
143Granulocytopenia (HP:0001913)1.85705805
144Abnormal trabecular bone morphology (HP:0100671)1.84623347
145Cleft eyelid (HP:0000625)1.83481448
146Retinal dysplasia (HP:0007973)1.83196683
147Prostate neoplasm (HP:0100787)1.81032922
148Congenital, generalized hypertrichosis (HP:0004540)1.79809668
149Abnormality of eosinophils (HP:0001879)1.77352454
1503-Methylglutaconic aciduria (HP:0003535)1.75775127
151Anencephaly (HP:0002323)1.72371285
152Abnormal drinking behavior (HP:0030082)1.71813972
153Polydipsia (HP:0001959)1.71813972
154Abnormality of T cell physiology (HP:0011840)1.71210088
155Postaxial foot polydactyly (HP:0001830)1.70497762
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.70307056
157Congenital primary aphakia (HP:0007707)1.68461733
158Small hand (HP:0200055)1.68085991
159Methylmalonic acidemia (HP:0002912)1.67098709
160Increased hepatocellular lipid droplets (HP:0006565)1.67044237
161Constricted visual fields (HP:0001133)1.66403726
162Congenital hepatic fibrosis (HP:0002612)1.65202481
163Large for gestational age (HP:0001520)1.64389928
164Nephrogenic diabetes insipidus (HP:0009806)1.62865517
165Generalized hypopigmentation of hair (HP:0011358)1.62452740
166Increased CSF lactate (HP:0002490)1.62265575
167Astigmatism (HP:0000483)1.61691014
168Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.61089875
169Increased serum lactate (HP:0002151)1.60571824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.59971494
2CDC74.26213090
3BUB14.20042368
4FRK3.79683101
5EIF2AK13.15598559
6NEK23.08271143
7ACVR1B2.95831550
8NUAK12.84432701
9BRSK22.83978437
10PLK42.61189109
11SRPK12.58033945
12TTK2.28206408
13BMPR1B2.26760515
14VRK12.17114346
15PLK12.09777894
16MAP4K12.08409686
17STK162.05436022
18EIF2AK32.00695406
19ADRBK21.98360712
20NME21.97466000
21NEK11.97082309
22MKNK11.90317777
23CCNB11.89845637
24WNK31.88525141
25AURKB1.78194837
26TRIM281.71027294
27ATR1.70514365
28GRK11.67383469
29BRSK11.66816965
30PLK31.61158169
31TXK1.57537493
32STK101.57081531
33TSSK61.54652584
34MAPK131.52342391
35MAP4K21.49964540
36CDK71.49494203
37STK41.47284879
38PINK11.46313876
39CHEK21.45305970
40RPS6KA41.39747489
41CAMKK21.37439670
42MKNK21.35010399
43TEC1.30890679
44BCR1.29655204
45MAP3K41.28686298
46CDK41.23331635
47DYRK31.22844504
48WNK41.21822118
49MAP3K81.21611417
50CDK81.14476984
51TLK11.13088107
52PIM11.11071159
53CHEK11.10801768
54ZAK1.07430114
55CLK11.03854713
56AURKA1.03156420
57IKBKE1.02599173
58TGFBR11.02591455
59INSRR1.01502612
60PBK1.00456500
61MAPKAPK31.00058971
62RPS6KB20.99261748
63EIF2AK20.98636841
64PIK3CA0.96785974
65TESK20.93220217
66ATM0.93167226
67PASK0.90771864
68BTK0.88684195
69SCYL20.87467517
70BCKDK0.86814098
71TNIK0.84484982
72PIM20.80684927
73MST40.78693455
74EPHA30.78588560
75IRAK40.76577918
76KIT0.75484737
77MAP2K70.74892905
78STK38L0.73718688
79MELK0.72753890
80CDK20.71610540
81FLT30.71473313
82AKT30.68956126
83SIK30.68788212
84OXSR10.66621361
85CSNK2A10.66462051
86CDK10.65891307
87BMPR20.65186481
88GRK60.64945801
89PLK20.64134946
90RPS6KA50.63927368
91MAP3K140.63312898
92PRKCQ0.62161855
93CDK60.61929547
94PNCK0.61658547
95CSNK2A20.59204825
96PAK30.59172743
97MUSK0.58420206
98ZAP700.57937557
99CASK0.57277197
100JAK30.56967691
101NEK90.55026381
102LRRK20.51766901
103MAP2K30.51268475
104CSF1R0.50753133
105ADRBK10.50325414
106CDK120.50019139
107STK390.49892140
108TYK20.48995073
109STK30.48151081
110CSNK1G20.47499327
111BRD40.47040981
112SIK20.46277935
113BRAF0.45242024
114LYN0.44450684
115PRKCG0.43534545
116ITK0.42003204
117PRKCI0.41609563
118KDR0.40936496
119TAOK30.40900991
120PAK40.39318270
121MAPK150.38355541
122SYK0.36865122
123NME10.35821575
124TRPM70.35629889
125PRKCE0.35602222
126PAK10.35538904
127MARK30.32494107
128NEK60.31095415
129EEF2K0.30937636
130CSNK1A1L0.30500053
131CSNK1G30.30108575
132LCK0.29814958
133IKBKB0.27985840
134YES10.26538634
135CSNK1G10.25940806
136PRKDC0.25554463
137CHUK0.24307437
138ALK0.24209723
139CDK30.22256525
140MAPKAPK50.21769845
141RAF10.19279296
142NLK0.19158174
143ERBB30.18371388
144RPS6KB10.18242148
145MAPK140.17779270

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.11005912
2Mismatch repair_Homo sapiens_hsa034304.52075585
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53125484
4Homologous recombination_Homo sapiens_hsa034403.48482531
5Base excision repair_Homo sapiens_hsa034103.18501009
6RNA polymerase_Homo sapiens_hsa030203.13318334
7Spliceosome_Homo sapiens_hsa030403.06288213
8Non-homologous end-joining_Homo sapiens_hsa034502.94714097
9Cell cycle_Homo sapiens_hsa041102.92392286
10Nucleotide excision repair_Homo sapiens_hsa034202.90756247
11Ribosome_Homo sapiens_hsa030102.88016838
12Proteasome_Homo sapiens_hsa030502.86431035
13RNA transport_Homo sapiens_hsa030132.77587827
14Fanconi anemia pathway_Homo sapiens_hsa034602.66133052
15Basal transcription factors_Homo sapiens_hsa030222.39963219
16Nitrogen metabolism_Homo sapiens_hsa009102.39851538
17Pyrimidine metabolism_Homo sapiens_hsa002402.33158204
18One carbon pool by folate_Homo sapiens_hsa006701.98453864
19RNA degradation_Homo sapiens_hsa030181.96027814
20Phototransduction_Homo sapiens_hsa047441.93941525
21Linoleic acid metabolism_Homo sapiens_hsa005911.82347572
22p53 signaling pathway_Homo sapiens_hsa041151.68902185
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66425133
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61243134
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49841694
26Regulation of autophagy_Homo sapiens_hsa041401.47980449
27mRNA surveillance pathway_Homo sapiens_hsa030151.47200466
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46878816
29Nicotine addiction_Homo sapiens_hsa050331.40296111
30Caffeine metabolism_Homo sapiens_hsa002321.38484561
31Purine metabolism_Homo sapiens_hsa002301.36028327
32Primary immunodeficiency_Homo sapiens_hsa053401.34298440
33Systemic lupus erythematosus_Homo sapiens_hsa053221.26225428
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25063870
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22276828
36Herpes simplex infection_Homo sapiens_hsa051681.21507453
37Circadian rhythm_Homo sapiens_hsa047101.20928287
38Epstein-Barr virus infection_Homo sapiens_hsa051691.19046906
39Propanoate metabolism_Homo sapiens_hsa006401.17257207
40Butanoate metabolism_Homo sapiens_hsa006501.16402273
41Ether lipid metabolism_Homo sapiens_hsa005651.15727057
42Oxidative phosphorylation_Homo sapiens_hsa001901.12893609
43Antigen processing and presentation_Homo sapiens_hsa046121.10457450
44Olfactory transduction_Homo sapiens_hsa047401.09443118
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08950238
46Protein export_Homo sapiens_hsa030601.06162548
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94876053
48Viral carcinogenesis_Homo sapiens_hsa052030.93492479
49Vitamin B6 metabolism_Homo sapiens_hsa007500.93286389
50Oocyte meiosis_Homo sapiens_hsa041140.90336075
51Taste transduction_Homo sapiens_hsa047420.86657176
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80975519
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.78597568
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76285839
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76237866
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75817358
57Folate biosynthesis_Homo sapiens_hsa007900.74978615
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.74767844
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74224030
60Type I diabetes mellitus_Homo sapiens_hsa049400.73628423
61Measles_Homo sapiens_hsa051620.72724856
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.72569645
63Hematopoietic cell lineage_Homo sapiens_hsa046400.72485841
64HTLV-I infection_Homo sapiens_hsa051660.71438463
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70135578
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.68919522
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66524796
68Pentose phosphate pathway_Homo sapiens_hsa000300.65257473
69Morphine addiction_Homo sapiens_hsa050320.65107651
70Tryptophan metabolism_Homo sapiens_hsa003800.64217331
71Small cell lung cancer_Homo sapiens_hsa052220.63003372
72Dorso-ventral axis formation_Homo sapiens_hsa043200.61541458
73Peroxisome_Homo sapiens_hsa041460.60380375
74ABC transporters_Homo sapiens_hsa020100.60294720
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59509408
76Allograft rejection_Homo sapiens_hsa053300.59267654
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58797703
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58303194
79Thyroid cancer_Homo sapiens_hsa052160.57148123
80Selenocompound metabolism_Homo sapiens_hsa004500.56719904
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55928448
82MicroRNAs in cancer_Homo sapiens_hsa052060.54610449
83Apoptosis_Homo sapiens_hsa042100.52742857
84Legionellosis_Homo sapiens_hsa051340.52303034
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51658455
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48569191
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48087096
88Graft-versus-host disease_Homo sapiens_hsa053320.46246654
89Hepatitis B_Homo sapiens_hsa051610.45712797
90Influenza A_Homo sapiens_hsa051640.44832068
91Sulfur relay system_Homo sapiens_hsa041220.44255091
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.42629412
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42193617
94Asthma_Homo sapiens_hsa053100.41525685
95Huntingtons disease_Homo sapiens_hsa050160.40074071
96Shigellosis_Homo sapiens_hsa051310.38608147
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.36524493
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35996093
99Autoimmune thyroid disease_Homo sapiens_hsa053200.33097622
100Glutathione metabolism_Homo sapiens_hsa004800.32528814
101Alcoholism_Homo sapiens_hsa050340.32474685
102Leishmaniasis_Homo sapiens_hsa051400.32295779
103Serotonergic synapse_Homo sapiens_hsa047260.31545466
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30638197
105N-Glycan biosynthesis_Homo sapiens_hsa005100.30604696
106Colorectal cancer_Homo sapiens_hsa052100.28007467
107Alzheimers disease_Homo sapiens_hsa050100.27355854
108B cell receptor signaling pathway_Homo sapiens_hsa046620.26892019
109Parkinsons disease_Homo sapiens_hsa050120.24913709
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.24347853
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.24189081
112Rheumatoid arthritis_Homo sapiens_hsa053230.24154449
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24071370
114TGF-beta signaling pathway_Homo sapiens_hsa043500.23742213
115Viral myocarditis_Homo sapiens_hsa054160.22527349
116Biosynthesis of amino acids_Homo sapiens_hsa012300.20554292
117T cell receptor signaling pathway_Homo sapiens_hsa046600.19409702
118Pancreatic cancer_Homo sapiens_hsa052120.18564669
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18544375
120Pathways in cancer_Homo sapiens_hsa052000.18446064
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16874295
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15788070
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15085615
124Chronic myeloid leukemia_Homo sapiens_hsa052200.14956211
125Metabolic pathways_Homo sapiens_hsa011000.14867580
126Arachidonic acid metabolism_Homo sapiens_hsa005900.13836295
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13788964
128Renin-angiotensin system_Homo sapiens_hsa046140.12803044
129Toxoplasmosis_Homo sapiens_hsa051450.11935315
130Platelet activation_Homo sapiens_hsa046110.11863130
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11734179
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.10608833
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09535802
134FoxO signaling pathway_Homo sapiens_hsa040680.08995407
135Acute myeloid leukemia_Homo sapiens_hsa052210.08926343
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07914296

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