HAS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)9.88060246
2cornea development in camera-type eye (GO:0061303)6.74398549
3negative regulation of stress fiber assembly (GO:0051497)6.37415130
4protein heterotrimerization (GO:0070208)6.22824133
5extracellular fibril organization (GO:0043206)6.00090484
6myelination in peripheral nervous system (GO:0022011)5.91908942
7peripheral nervous system axon ensheathment (GO:0032292)5.91908942
8myoblast migration (GO:0051451)5.86117348
9negative regulation of Rho protein signal transduction (GO:0035024)5.72888783
10collagen fibril organization (GO:0030199)5.59162725
11skeletal muscle adaptation (GO:0043501)5.57963522
12regulation of vitamin D biosynthetic process (GO:0060556)5.45665257
13fibril organization (GO:0097435)5.42736287
14positive regulation of heat generation (GO:0031652)4.99721000
15cellular response to cadmium ion (GO:0071276)4.98861483
16negative regulation of actin filament bundle assembly (GO:0032232)4.89740477
17keratan sulfate biosynthetic process (GO:0018146)4.85135314
18peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.78828901
19response to peptidoglycan (GO:0032494)4.62978947
20ovulation from ovarian follicle (GO:0001542)4.61261734
21endothelial cell morphogenesis (GO:0001886)4.60787303
22positive regulation of p38MAPK cascade (GO:1900745)4.54640434
23epithelial cell-cell adhesion (GO:0090136)4.35323232
24regulation of fever generation (GO:0031620)4.32441598
25regulation of chemokine biosynthetic process (GO:0045073)4.32410496
26neuronal ion channel clustering (GO:0045161)4.30364981
27negative regulation of interleukin-12 production (GO:0032695)4.27973504
28sequestering of extracellular ligand from receptor (GO:0035581)4.22214195
29regulation of vitamin metabolic process (GO:0030656)4.20355338
30regulation of T-helper 2 cell differentiation (GO:0045628)4.11199962
31regulation of T-helper 1 cell differentiation (GO:0045625)4.10336083
32low-density lipoprotein particle clearance (GO:0034383)4.05528016
33* extracellular matrix assembly (GO:0085029)4.02889135
34keratan sulfate metabolic process (GO:0042339)4.01976922
35negative regulation of nitric oxide biosynthetic process (GO:0045019)3.96724838
36complement activation, alternative pathway (GO:0006957)3.92137904
37regulation of plasminogen activation (GO:0010755)3.89118881
38regulation of heat generation (GO:0031650)3.87138784
39regulation of membrane protein ectodomain proteolysis (GO:0051043)3.85632652
40positive regulation of chemokine biosynthetic process (GO:0045080)3.84249507
41muscle cell migration (GO:0014812)3.82924213
42collagen metabolic process (GO:0032963)3.79373413
43regulation of mitochondrial depolarization (GO:0051900)3.70706457
44bone trabecula formation (GO:0060346)3.69884198
45skin morphogenesis (GO:0043589)3.68357304
46regulation of nitric oxide biosynthetic process (GO:0045428)3.67768772
47regulation of mononuclear cell migration (GO:0071675)3.67639771
48regulation of chronic inflammatory response (GO:0002676)3.63137101
49multicellular organismal macromolecule metabolic process (GO:0044259)3.61179258
50positive regulation of type 2 immune response (GO:0002830)3.60862643
51positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.60247149
52ovulation (GO:0030728)3.59441295
53regulation of dendritic cell antigen processing and presentation (GO:0002604)3.58786106
54positive regulation of nitric oxide biosynthetic process (GO:0045429)3.58743929
55positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.55572457
56collagen catabolic process (GO:0030574)3.55440980
57detection of molecule of bacterial origin (GO:0032490)3.54815987
58regulation of p38MAPK cascade (GO:1900744)3.50049122
59behavioral response to pain (GO:0048266)3.49599927
60positive regulation of cell junction assembly (GO:1901890)3.45657164
61positive regulation of focal adhesion assembly (GO:0051894)3.45657164
62regulation of cytokine secretion involved in immune response (GO:0002739)3.44025010
63multicellular organismal metabolic process (GO:0044236)3.42236666
64positive regulation of adherens junction organization (GO:1903393)3.42126780
65regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.41500207
66chondrocyte proliferation (GO:0035988)3.41384249
67negative regulation of lipid storage (GO:0010888)3.40320001
68lipopolysaccharide-mediated signaling pathway (GO:0031663)3.39662199
69dermatan sulfate biosynthetic process (GO:0030208)3.36976268
70barbed-end actin filament capping (GO:0051016)3.36026839
71positive regulation of acute inflammatory response (GO:0002675)3.35933201
72regulation of heterotypic cell-cell adhesion (GO:0034114)3.34392313
73multicellular organismal catabolic process (GO:0044243)3.29190506
74blood vessel maturation (GO:0001955)3.28267228
75germinal center formation (GO:0002467)3.27172573
76oxygen transport (GO:0015671)3.25443166
77regulation of immunoglobulin secretion (GO:0051023)3.25130799
78defense response to protozoan (GO:0042832)3.22225137
79response to inactivity (GO:0014854)3.17738906
80negative regulation of amino acid transport (GO:0051956)3.16536791
81positive regulation of macrophage cytokine production (GO:0060907)3.14284780
82wound healing, spreading of epidermal cells (GO:0035313)3.11284530
83negative regulation of interleukin-8 production (GO:0032717)3.10479391
84regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.09432662
85retina vasculature morphogenesis in camera-type eye (GO:0061299)3.08451478
86positive regulation of neutrophil chemotaxis (GO:0090023)3.08397218
87positive regulation of neutrophil migration (GO:1902624)3.08397218
88response to protozoan (GO:0001562)3.08223137
89sulfur compound catabolic process (GO:0044273)3.07849648
90NIK/NF-kappaB signaling (GO:0038061)3.07050257
91regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.06281483
92response to BMP (GO:0071772)3.06149729
93cellular response to BMP stimulus (GO:0071773)3.06149729
94cellular sodium ion homeostasis (GO:0006883)3.05422901
95short-term memory (GO:0007614)3.05167574
96positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.04162299
97regulation of complement activation (GO:0030449)3.02654978
98dermatan sulfate metabolic process (GO:0030205)3.02214805
99negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.02118488
100negative regulation of cell-matrix adhesion (GO:0001953)3.02071154
101growth hormone secretion (GO:0030252)3.01595518
102regulation of type 2 immune response (GO:0002828)3.01035549
103neuron projection extension involved in neuron projection guidance (GO:1902284)3.00997089
104axon extension involved in axon guidance (GO:0048846)3.00997089
105negative regulation of cytokine production involved in immune response (GO:0002719)2.99915238
106cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.99710149
107regulation of interferon-alpha production (GO:0032647)2.99208324
108positive regulation of astrocyte differentiation (GO:0048711)2.98380281
109type I interferon signaling pathway (GO:0060337)2.97002560
110cellular response to type I interferon (GO:0071357)2.97002560
111endodermal cell differentiation (GO:0035987)2.95585964
112negative regulation of gluconeogenesis (GO:0045721)2.95062768
113regulation of macrophage cytokine production (GO:0010935)2.94091043
114response to type I interferon (GO:0034340)2.92636226
115positive regulation of granulocyte chemotaxis (GO:0071624)2.92002981
116interleukin-6-mediated signaling pathway (GO:0070102)2.91445057
117macrophage activation involved in immune response (GO:0002281)2.91303283
118positive regulation of T-helper cell differentiation (GO:0045624)2.90203147
119extracellular matrix disassembly (GO:0022617)2.87275060
120monocyte chemotaxis (GO:0002548)2.86481773
121negative regulation of tumor necrosis factor production (GO:0032720)2.85003545
122T-helper 1 type immune response (GO:0042088)2.84367912
123opsonization (GO:0008228)2.83575393
124positive regulation of interleukin-6 production (GO:0032755)2.82864390
125glycosaminoglycan catabolic process (GO:0006027)2.82749286
126regulation of podosome assembly (GO:0071801)2.81927081
127regulation of T-helper cell differentiation (GO:0045622)2.81738572
128* extracellular matrix organization (GO:0030198)2.81365254
129CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.80728852
130* extracellular structure organization (GO:0043062)2.80272895
131cellular response to lipopolysaccharide (GO:0071222)2.76043316
132regulation of cardiac muscle cell differentiation (GO:2000725)2.75892236
133negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.75686262
134UDP-N-acetylglucosamine metabolic process (GO:0006047)2.74501523
135positive regulation of NF-kappaB import into nucleus (GO:0042346)2.74264068
136striated muscle hypertrophy (GO:0014897)2.73303009
137adhesion of symbiont to host (GO:0044406)2.72524060
138regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.70677407
139regulation of protein import into nucleus, translocation (GO:0033158)2.70276879
140regulation of interleukin-8 biosynthetic process (GO:0045414)2.69766916
141positive regulation of chemokine production (GO:0032722)2.69632309
142regulation of Rho protein signal transduction (GO:0035023)2.68986500
143regulation of protein activation cascade (GO:2000257)2.68893462
144cellular response to molecule of bacterial origin (GO:0071219)2.66926467
145JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.66831359
146decidualization (GO:0046697)2.65375529
147positive regulation of natural killer cell differentiation (GO:0032825)2.64616391
148cell adhesion mediated by integrin (GO:0033627)2.63883874
149negative regulation of cytokine secretion (GO:0050710)2.63024855
150response to manganese ion (GO:0010042)2.62166075
151aminoglycan catabolic process (GO:0006026)2.61944752
152glomerular basement membrane development (GO:0032836)2.61708643
153myeloid dendritic cell differentiation (GO:0043011)2.60764894
154negative regulation of complement activation (GO:0045916)2.60655161
155regulation of type I interferon-mediated signaling pathway (GO:0060338)2.59881480
156regulation of interleukin-6 production (GO:0032675)2.56847935
157response to muramyl dipeptide (GO:0032495)2.56276940
158negative regulation of heart growth (GO:0061117)2.55864067
159negative regulation of cardiac muscle tissue growth (GO:0055022)2.55864067
160negative regulation of organic acid transport (GO:0032891)2.54906086
161regulation of NF-kappaB import into nucleus (GO:0042345)2.53855850
162positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.53302760
163negative regulation of production of molecular mediator of immune response (GO:0002701)2.53071828
164muscle cell fate commitment (GO:0042693)2.52091388
165apoptotic cell clearance (GO:0043277)2.51920798
166chronic inflammatory response (GO:0002544)2.51121524
167positive regulation of cholesterol efflux (GO:0010875)2.49149247
168smooth muscle tissue development (GO:0048745)2.48271752
169branching involved in labyrinthine layer morphogenesis (GO:0060670)2.45870391
170regulation of vascular endothelial growth factor production (GO:0010574)2.45562624
171tissue remodeling (GO:0048771)2.45482674
172muscle hypertrophy (GO:0014896)2.43991024
173* glycosaminoglycan biosynthetic process (GO:0006024)2.43759029
174mRNA transcription (GO:0009299)2.42678278
175regulation of lipid storage (GO:0010883)2.41588988
176negative regulation of smooth muscle cell migration (GO:0014912)2.40718638
177regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.40256568
178activation of MAPKKK activity (GO:0000185)2.39615066
179virion attachment to host cell (GO:0019062)2.39315929
180adhesion of symbiont to host cell (GO:0044650)2.39315929
181* aminoglycan biosynthetic process (GO:0006023)2.39060092
182positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.38850182
183positive regulation of lipid storage (GO:0010884)2.38691259
184non-canonical Wnt signaling pathway (GO:0035567)2.38687966
185negative regulation of monooxygenase activity (GO:0032769)2.38409698
186regulation of neutrophil chemotaxis (GO:0090022)2.36933931
187regulation of neutrophil migration (GO:1902622)2.36933931
188cell aggregation (GO:0098743)2.36125645
189negative regulation of cytokine biosynthetic process (GO:0042036)2.33350729
190regulation of interleukin-12 production (GO:0032655)2.33240551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.79812773
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.79764631
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.96162988
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.81169838
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.53802344
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53743404
7ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.38244285
8CLOCK_20551151_ChIP-Seq_293T_Human2.36403309
9EZH2_22144423_ChIP-Seq_EOC_Human2.35856107
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.24092079
11* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.22051091
12CJUN_26792858_Chip-Seq_BT549_Human2.20289541
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.19159886
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16429523
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.16327709
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15951400
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12427500
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10855334
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.09925179
20* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08668926
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06520077
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05097319
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.04850385
24AR_21572438_ChIP-Seq_LNCaP_Human2.02911847
25* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02147952
26CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01481349
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.00938953
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00246339
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00246339
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99881951
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97342129
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96417531
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.95163872
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89829154
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85129664
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.82878760
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73241865
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73099666
39GBX2_23144817_ChIP-Seq_PC3_Human1.70467434
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67786934
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.67414684
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66800778
43VDR_21846776_ChIP-Seq_THP-1_Human1.66344428
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.65168853
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.64719447
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61022924
47VDR_24763502_ChIP-Seq_THP-1_Human1.60566334
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.60431015
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60342202
50TP53_16413492_ChIP-PET_HCT116_Human1.60218023
51TP53_18474530_ChIP-ChIP_U2OS_Human1.56030195
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55341603
53* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55203492
54* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54435929
55LXR_22292898_ChIP-Seq_THP-1_Human1.51172055
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48942328
57DROSHA_22980978_ChIP-Seq_HELA_Human1.48614898
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46914763
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.44568017
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44346054
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42981594
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42981594
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42706919
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38827315
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38605263
66* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37132283
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36971879
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36952898
69* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36610969
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.35735812
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34186492
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33690429
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28890607
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28028090
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26404411
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25343180
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24639349
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23171044
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23171044
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23171044
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.22377978
82* BRD4_25478319_ChIP-Seq_HGPS_Human1.22312578
83* EZH2_27294783_Chip-Seq_ESCs_Mouse1.21159430
84* UBF1/2_26484160_Chip-Seq_HMECs_Human1.20843589
85KDM2B_26808549_Chip-Seq_DND41_Human1.19661385
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17423658
87RACK7_27058665_Chip-Seq_MCF-7_Human1.16924426
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15375640
89TCF7_22412390_ChIP-Seq_EML_Mouse1.14976141
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14662540
91VDR_24787735_ChIP-Seq_THP-1_Human1.12089064
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12069512
93AHR_22903824_ChIP-Seq_MCF-7_Human1.11491735
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11375428
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10870199
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10635980
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09662214
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09471821
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09437040
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08673924
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08326635
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.08216243
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08193484
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08193484
105TBX20_22080862_ChIP-Seq_HEART_Mouse1.06887610
106TBX20_22328084_ChIP-Seq_HEART_Mouse1.06887610
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06733245
108ELK3_25401928_ChIP-Seq_HUVEC_Human1.06638476
109KDM2B_26808549_Chip-Seq_K562_Human1.06595498
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06582733
111FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06501784
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05465504
113RXR_22158963_ChIP-Seq_LIVER_Mouse1.05302900
114SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05152867
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03816352
116STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03019317
117WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02347991
118RXR_22108803_ChIP-Seq_LS180_Human1.02151030
119SOX2_20726797_ChIP-Seq_SW620_Human1.01660906
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01614637
121* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00804212
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00070916
123SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99164247
124GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96775445
125* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95477405
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93751898
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93704090
128SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93695121
129GATA1_22025678_ChIP-Seq_K562_Human0.93359659
130SMAD4_21799915_ChIP-Seq_A2780_Human0.93045216
131GATA1_19941826_ChIP-Seq_K562_Human0.93030961
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92605178
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.92305237
134TCF4_18268006_ChIP-ChIP_LS174T_Human0.92074398
135MAF_26560356_Chip-Seq_TH1_Human0.91978158
136TP53_20018659_ChIP-ChIP_R1E_Mouse0.91678735
137ESR1_20079471_ChIP-ChIP_T-47D_Human0.90867585
138CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89492880
139LXR_22158963_ChIP-Seq_LIVER_Mouse0.88849250
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.88718735
141KLF5_25053715_ChIP-Seq_YYC3_Human0.88077723
142SA1_22415368_ChIP-Seq_MEFs_Mouse0.87446813
143E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86944704
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86603059
145TP53_22127205_ChIP-Seq_IMR90_Human0.86190420
146ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86149397
147ERG_21242973_ChIP-ChIP_JURKAT_Human0.85784053
148PU_27001747_Chip-Seq_BMDM_Mouse0.84778605
149* EGR1_19032775_ChIP-ChIP_M12_Human0.84694141
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83488404
151SPI1_23127762_ChIP-Seq_K562_Human0.83428809
152ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80867325
153BCAT_22108803_ChIP-Seq_LS180_Human0.80567498
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80512204
155BP1_19119308_ChIP-ChIP_Hs578T_Human0.80333678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology8.54798931
2MP0008438_abnormal_cutaneous_collagen7.38663170
3MP0005275_abnormal_skin_tensile6.93328573
4MP0005257_abnormal_intraocular_pressure6.43279566
5MP0001958_emphysema3.13287985
6MP0006082_CNS_inflammation2.98320670
7MP0003436_decreased_susceptibility_to2.96725437
8MP0002108_abnormal_muscle_morphology2.76456270
9MP0005508_abnormal_skeleton_morphology2.69040364
10MP0003724_increased_susceptibility_to2.64356055
11MP0003303_peritoneal_inflammation2.47312481
12MP0009785_altered_susceptibility_to2.42464725
13MP0004272_abnormal_basement_membrane2.39361939
14MP0006054_spinal_hemorrhage2.37541148
15MP0002148_abnormal_hypersensitivity_rea2.36634714
16MP0009840_abnormal_foam_cell2.21790596
17MP0003279_aneurysm2.21310108
18MP0003300_gastrointestinal_ulcer2.18523000
19MP0000751_myopathy2.07874931
20MP0002254_reproductive_system_inflammat2.06594535
21MP0002933_joint_inflammation2.05016324
22MP0002060_abnormal_skin_morphology2.03541981
23MP0003950_abnormal_plasma_membrane2.02632531
24MP0002332_abnormal_exercise_endurance2.01411857
25MP0005000_abnormal_immune_tolerance1.87364770
26MP0003705_abnormal_hypodermis_morpholog1.83469449
27MP0009764_decreased_sensitivity_to1.83017005
28MP0004947_skin_inflammation1.81504244
29MP0005390_skeleton_phenotype1.79747648
30MP0005387_immune_system_phenotype1.79189821
31MP0001790_abnormal_immune_system1.79189821
32MP0005058_abnormal_lysosome_morphology1.78830878
33MP0010368_abnormal_lymphatic_system1.78724753
34MP0005451_abnormal_body_composition1.71164217
35MP0002419_abnormal_innate_immunity1.65788242
36MP0003453_abnormal_keratinocyte_physiol1.64971362
37MP0002295_abnormal_pulmonary_circulatio1.62975879
38MP0005167_abnormal_blood-brain_barrier1.61754446
39MP0005023_abnormal_wound_healing1.60658351
40MP0005025_abnormal_response_to1.56999878
41MP0003566_abnormal_cell_adhesion1.55272603
42MP0005623_abnormal_meninges_morphology1.48137738
43MP0001835_abnormal_antigen_presentation1.48118513
44MP0004510_myositis1.45345691
45MP0000750_abnormal_muscle_regeneration1.38836768
46MP0005076_abnormal_cell_differentiation1.38456962
47MP0003690_abnormal_glial_cell1.36508146
48MP0001533_abnormal_skeleton_physiology1.36054609
49MP0001542_abnormal_bone_strength1.34423661
50MP0002405_respiratory_system_inflammati1.34193766
51MP0003075_altered_response_to1.31473667
52MP0001545_abnormal_hematopoietic_system1.28675893
53MP0005397_hematopoietic_system_phenotyp1.28675893
54MP0000858_altered_metastatic_potential1.25793032
55MP0000343_altered_response_to1.20139061
56MP0002723_abnormal_immune_serum1.19470198
57MP0001853_heart_inflammation1.18718556
58MP0002452_abnormal_antigen_presenting1.17618542
59MP0008469_abnormal_protein_level1.17192769
60MP0001845_abnormal_inflammatory_respons1.16410129
61MP0003045_fibrosis1.16313583
62MP0000163_abnormal_cartilage_morphology1.16257100
63MP0000013_abnormal_adipose_tissue1.16126397
64MP0005164_abnormal_response_to1.12441243
65MP0009250_abnormal_appendicular_skeleto1.07936386
66MP0001243_abnormal_dermal_layer1.06693285
67MP0010155_abnormal_intestine_physiology1.06273473
68MP0002282_abnormal_trachea_morphology1.02605809
69MP0002998_abnormal_bone_remodeling1.02477637
70MP0000767_abnormal_smooth_muscle1.02223357
71MP0003091_abnormal_cell_migration1.01947515
72MP0005666_abnormal_adipose_tissue1.01424548
73MP0005369_muscle_phenotype1.01329924
74MP0008004_abnormal_stomach_pH0.98527472
75MP0005197_abnormal_uvea_morphology0.97930581
76MP0001800_abnormal_humoral_immune0.97337633
77MP0005165_increased_susceptibility_to0.96171281
78MP0002115_abnormal_skeleton_extremities0.95882133
79MP0003828_pulmonary_edema0.95874593
80MP0002133_abnormal_respiratory_system0.95504881
81MP0005388_respiratory_system_phenotype0.95504881
82MP0009780_abnormal_chondrocyte_physiolo0.94629202
83MP0005535_abnormal_body_temperature0.93640693
84MP0002896_abnormal_bone_mineralization0.93146877
85MP0005375_adipose_tissue_phenotype0.92670274
86MP0010030_abnormal_orbit_morphology0.91084476
87MP0002166_altered_tumor_susceptibility0.90837242
88MP0003191_abnormal_cellular_cholesterol0.89766348
89MP0001879_abnormal_lymphatic_vessel0.87077801
90MP0004883_abnormal_blood_vessel0.86983590
91MP0005595_abnormal_vascular_smooth0.84875288
92MP0009278_abnormal_bone_marrow0.84658612
93MP0009763_increased_sensitivity_to0.82952137
94MP0002006_tumorigenesis0.82736001
95MP0001819_abnormal_immune_cell0.82707329
96MP0002420_abnormal_adaptive_immunity0.81946147
97MP0010352_gastrointestinal_tract_polyps0.80696627
98MP0003115_abnormal_respiratory_system0.80404029
99MP0000685_abnormal_immune_system0.79581769
100MP0000604_amyloidosis0.78983862
101MP0002113_abnormal_skeleton_development0.78810958
102MP0002090_abnormal_vision0.78473389
103MP0003448_altered_tumor_morphology0.77671364
104MP0003941_abnormal_skin_development0.76954670
105MP0003385_abnormal_body_wall0.76874163
106MP0005171_absent_coat_pigmentation0.75426919
107MP0005671_abnormal_response_to0.74900702
108MP0010771_integument_phenotype0.73331793
109MP0000733_abnormal_muscle_development0.73314919
110MP0001851_eye_inflammation0.72669758
111MP0000534_abnormal_ureter_morphology0.71211104
112MP0002877_abnormal_melanocyte_morpholog0.70816841
113MP0004808_abnormal_hematopoietic_stem0.70752733
114MP0003656_abnormal_erythrocyte_physiolo0.69807771
115MP0001501_abnormal_sleep_pattern0.69250041
116MP0001299_abnormal_eye_distance/0.68180325
117MP0002249_abnormal_larynx_morphology0.67292051
118MP0004858_abnormal_nervous_system0.66689368
119MP0003172_abnormal_lysosome_physiology0.65796484
120MP0004233_abnormal_muscle_weight0.65783294
121MP0000747_muscle_weakness0.65181327
122MP0001177_atelectasis0.65058905
123MP0004484_altered_response_of0.63012023
124MP0009333_abnormal_splenocyte_physiolog0.62264335
125MP0009765_abnormal_xenobiotic_induced0.60023034
126MP0000249_abnormal_blood_vessel0.58745918
127MP0001175_abnormal_lung_morphology0.57323068
128MP0002106_abnormal_muscle_physiology0.56994303
129MP0003795_abnormal_bone_structure0.56025697
130MP0000749_muscle_degeneration0.55976415
131MP0002168_other_aberrant_phenotype0.55711272
132MP0004134_abnormal_chest_morphology0.55375361
133MP0009384_cardiac_valve_regurgitation0.54348778
134MP0002128_abnormal_blood_circulation0.52663811
135MP0001614_abnormal_blood_vessel0.52336222
136MP0000003_abnormal_adipose_tissue0.52176118
137MP0002932_abnormal_joint_morphology0.51892163
138MP0004087_abnormal_muscle_fiber0.48582638
139MP0005166_decreased_susceptibility_to0.45748902
140MP0000759_abnormal_skeletal_muscle0.45378607
141MP0002925_abnormal_cardiovascular_devel0.43033596
142MP0003283_abnormal_digestive_organ0.40807452
143MP0005330_cardiomyopathy0.39946314
144MP0002089_abnormal_postnatal_growth/wei0.39467644
145MP0002109_abnormal_limb_morphology0.39209925
146MP0008961_abnormal_basal_metabolism0.39009828
147MP0009053_abnormal_anal_canal0.38713695
148MP0004085_abnormal_heartbeat0.38504235
149MP0003942_abnormal_urinary_system0.38223210
150MP0004859_abnormal_synaptic_plasticity0.37823827

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.84022733
2Increased connective tissue (HP:0009025)5.78901719
3Premature rupture of membranes (HP:0001788)5.71429950
4Ankle contracture (HP:0006466)5.70451482
5Flat cornea (HP:0007720)5.14470402
6Broad metatarsal (HP:0001783)5.08540717
7Popliteal pterygium (HP:0009756)4.98259961
8Soft skin (HP:0000977)4.61863443
9Follicular hyperkeratosis (HP:0007502)4.45604157
10Muscle fiber splitting (HP:0003555)4.43364131
11Type 1 muscle fiber predominance (HP:0003803)4.28486755
12Spinal rigidity (HP:0003306)4.17846559
13Orchitis (HP:0100796)4.01210318
14Pulmonary artery stenosis (HP:0004415)4.00876554
15Aortic dissection (HP:0002647)4.00293126
16Abnormality of glycolipid metabolism (HP:0010969)3.96531364
17Abnormality of liposaccharide metabolism (HP:0010968)3.96531364
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.96531364
19Interstitial pulmonary disease (HP:0006530)3.88402085
20Wrist flexion contracture (HP:0001239)3.84876541
21Vertebral compression fractures (HP:0002953)3.83963897
22Slender build (HP:0001533)3.80512354
23Abnormality of placental membranes (HP:0011409)3.78221531
24Amniotic constriction ring (HP:0009775)3.78221531
25Optic neuritis (HP:0100653)3.75037448
26Retrobulbar optic neuritis (HP:0100654)3.75037448
27Striae distensae (HP:0001065)3.71358166
28Cerebral aneurysm (HP:0004944)3.69475747
29Dilatation of the ascending aorta (HP:0005111)3.67302207
30Systemic lupus erythematosus (HP:0002725)3.62654855
31Cervical subluxation (HP:0003308)3.62584580
32Shallow orbits (HP:0000586)3.60090155
33Amyloidosis (HP:0011034)3.58104534
34Bladder diverticulum (HP:0000015)3.47663416
35Mitral valve prolapse (HP:0001634)3.47245927
36Myositis (HP:0100614)3.45838620
37Aplasia of the musculature (HP:0100854)3.42038087
38Neonatal short-limb short stature (HP:0008921)3.39328185
39Fetal akinesia sequence (HP:0001989)3.35846194
40Rectal prolapse (HP:0002035)3.33289801
41Malignant hyperthermia (HP:0002047)3.33262232
42Complement deficiency (HP:0004431)3.20604858
43Recurrent gram-negative bacterial infections (HP:0005420)3.18441066
44Increased variability in muscle fiber diameter (HP:0003557)3.14920609
45Atrophic scars (HP:0001075)3.14606199
46Mildly elevated creatine phosphokinase (HP:0008180)3.12613251
47Aortic aneurysm (HP:0004942)3.12259240
48Bronchomalacia (HP:0002780)3.08483250
49Wormian bones (HP:0002645)3.07974793
50Abnormality of the neuromuscular junction (HP:0003398)3.06808432
51Fatigable weakness (HP:0003473)3.06808432
52Mesangial abnormality (HP:0001966)3.00633187
53Peritonitis (HP:0002586)2.97585734
54Thin ribs (HP:0000883)2.96924968
55Dysostosis multiplex (HP:0000943)2.91194174
56Type 2 muscle fiber atrophy (HP:0003554)2.88714347
57Abnormality of complement system (HP:0005339)2.88590800
58Hyperextensible skin (HP:0000974)2.86201846
59Muscle fiber atrophy (HP:0100295)2.84702256
60Akinesia (HP:0002304)2.83565933
61Round ear (HP:0100830)2.81215222
62Abnormality of skeletal muscle fiber size (HP:0012084)2.79178901
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77819009
64Abnormality of polysaccharide metabolism (HP:0011012)2.77819009
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77819009
66Easy fatigability (HP:0003388)2.75432354
67Joint laxity (HP:0001388)2.75142900
68Biconcave vertebral bodies (HP:0004586)2.73671576
69Fragile skin (HP:0001030)2.71718454
70Urinary glycosaminoglycan excretion (HP:0003541)2.64470119
71Mucopolysacchariduria (HP:0008155)2.64470119
72Abnormality of dentin (HP:0010299)2.60916074
73Myocardial infarction (HP:0001658)2.59977298
74Nuclear cataract (HP:0100018)2.57892219
75Osteoarthritis (HP:0002758)2.54701108
76Abnormality of macrophages (HP:0004311)2.49434394
77Genu recurvatum (HP:0002816)2.49038544
78Vascular tortuosity (HP:0004948)2.49037330
79Patent foramen ovale (HP:0001655)2.48768946
80Pterygium (HP:0001059)2.46404150
81Fused cervical vertebrae (HP:0002949)2.44024723
82Stomatitis (HP:0010280)2.42136499
83Duplicated collecting system (HP:0000081)2.39337939
84Distal lower limb amyotrophy (HP:0008944)2.39216321
85Axonal loss (HP:0003447)2.39157295
86Hypoventilation (HP:0002791)2.36835020
87Arterial tortuosity (HP:0005116)2.35767558
88Venous insufficiency (HP:0005293)2.34970435
89Venous abnormality (HP:0002624)2.34114025
90Narrow nasal bridge (HP:0000446)2.33116744
91Keratoconjunctivitis sicca (HP:0001097)2.32754700
92Mitral stenosis (HP:0001718)2.32420466
93Glomerulonephritis (HP:0000099)2.32275261
94Loss of speech (HP:0002371)2.32102684
95Gowers sign (HP:0003391)2.31210659
96Hypoplastic ischia (HP:0003175)2.26433778
97Mediastinal lymphadenopathy (HP:0100721)2.24888588
98Camptodactyly of toe (HP:0001836)2.23594155
99Asymmetric septal hypertrophy (HP:0001670)2.22809398
100Blue sclerae (HP:0000592)2.22339428
101Autoimmune thrombocytopenia (HP:0001973)2.21949570
102Aortic regurgitation (HP:0001659)2.21929431
103Broad ribs (HP:0000885)2.20834933
104Abnormal delivery (HP:0001787)2.19385267
105Osteolytic defects of the hand bones (HP:0009699)2.17529242
106Osteolytic defects of the phalanges of the hand (HP:0009771)2.17529242
107Generalized amyotrophy (HP:0003700)2.17257573
108Mild short stature (HP:0003502)2.13732358
109Abnormality of the pericardium (HP:0001697)2.12943859
110Short hallux (HP:0010109)2.11301490
111Neurofibrillary tangles (HP:0002185)2.05101713
112Eczematoid dermatitis (HP:0000976)2.04285959
113Keratoconjunctivitis (HP:0001096)2.03791713
114Abnormality of the costochondral junction (HP:0000919)2.03714310
115Thin bony cortex (HP:0002753)2.03019321
116Acrocyanosis (HP:0001063)2.02607169
117Hypoplasia of the iris (HP:0007676)2.02459605
118Mitral regurgitation (HP:0001653)2.02304582
119Hematochezia (HP:0002573)2.01968493
120Hemorrhage of the eye (HP:0011885)2.01966644
121Overgrowth (HP:0001548)2.01944273
122Abnormality of the ischium (HP:0003174)1.99398695
123Elbow flexion contracture (HP:0002987)1.95334884
124Elevated erythrocyte sedimentation rate (HP:0003565)1.94651039
125Distal lower limb muscle weakness (HP:0009053)1.93488031
126Aneurysm (HP:0002617)1.92729755
127Abnormality of the renal collecting system (HP:0004742)1.92481169
128Disinhibition (HP:0000734)1.92297081
129Ovoid vertebral bodies (HP:0003300)1.91853074
130Corneal dystrophy (HP:0001131)1.91835017
131Limited hip movement (HP:0008800)1.90954831
132Hypercortisolism (HP:0001578)1.90657033
133Lower limb amyotrophy (HP:0007210)1.90218398
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90075840
135Hip contracture (HP:0003273)1.89674172
136Abnormality of the acetabulum (HP:0003170)1.87744387
137Limb-girdle muscle weakness (HP:0003325)1.87595725
138Aplasia/Hypoplasia of the hallux (HP:0008362)1.87195930
139Delayed closure of the anterior fontanelle (HP:0001476)1.86292640
140Gangrene (HP:0100758)1.85905759
141Mutism (HP:0002300)1.85829065
142Vacuolated lymphocytes (HP:0001922)1.85323069
143Flexion contracture of toe (HP:0005830)1.85044726
144Joint contractures involving the joints of the feet (HP:0100492)1.85044726
145Ectopia lentis (HP:0001083)1.83671317
146Increased IgE level (HP:0003212)1.82586843
147Wide anterior fontanel (HP:0000260)1.81454093
148Atrioventricular block (HP:0001678)1.81088104
149Emphysema (HP:0002097)1.79564629
150Arterial thrombosis (HP:0004420)1.79119284
151Spondylolisthesis (HP:0003302)1.78447752
152Protruding ear (HP:0000411)1.77710342
153Thoracolumbar scoliosis (HP:0002944)1.76635988
154Increased cerebral lipofuscin (HP:0011813)1.75700652
155Ureteral duplication (HP:0000073)1.75633959
156Joint stiffness (HP:0001387)1.74995770
157Pulmonary infiltrates (HP:0002113)1.74838250
158Bulbar palsy (HP:0001283)1.73006642
159Disproportionate tall stature (HP:0001519)1.72925652
160Increased serum ferritin (HP:0003281)1.72113760
161Alopecia of scalp (HP:0002293)1.71023850
162Weak cry (HP:0001612)1.70461025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.74560944
2DDR24.36680362
3IRAK33.91973054
4EPHA33.54536031
5MAP3K33.39914601
6ERN13.08070579
7RIPK12.91776930
8SIK32.84063500
9TSSK62.74471127
10EPHB12.72683636
11TGFBR22.47793671
12CSK2.08862045
13FGFR42.00216376
14PDGFRA1.99698435
15GRK71.99025069
16FER1.87712021
17PTK2B1.85107058
18MAP3K141.82032512
19IRAK41.77329594
20PIM21.75197873
21BLK1.75073988
22CLK11.69170138
23CDC42BPA1.68290561
24TIE11.56726459
25TTN1.54195447
26SIK11.50719678
27MAP2K31.47852153
28MAPK151.47481109
29IRAK11.43747938
30BMPR21.42392246
31MAPKAPK51.41912628
32BCR1.38629674
33NME21.38455727
34EPHB21.36838971
35LATS11.36099260
36IRAK21.34795950
37MOS1.33862032
38GRK51.33103444
39LATS21.32826960
40ERBB41.32133974
41PLK21.28958492
42MAP3K111.28344529
43MAP3K61.26384596
44TBK11.25396080
45ABL21.23624058
46ZAP701.21325923
47TYK21.20703848
48TRIB31.18432526
49PRKCH1.16205962
50BMX1.14699884
51MATK1.13857114
52JAK31.08822870
53GSK3A1.08437473
54DMPK1.08187811
55TAOK11.08166953
56DAPK21.07696365
57PRKD31.05540706
58FGFR31.03443223
59ADRBK21.03284871
60ERBB31.00587620
61MAP3K20.97189470
62PDGFRB0.97189050
63PAK20.95805633
64MAP3K50.92082228
65MYLK0.86560559
66MAP3K10.85820254
67MST1R0.83797497
68PAK40.82021502
69WNK10.81594153
70KSR10.78733059
71IKBKB0.74985403
72SIK20.74817038
73MAPK40.74671651
74EPHA40.74183447
75TRPM70.73306573
76CASK0.70550852
77JAK20.70444780
78JAK10.69857510
79PIK3CG0.69421057
80CDK60.67631258
81NTRK30.67205581
82TESK10.66982500
83CDK150.66592857
84PTK20.65848984
85IKBKE0.64889454
86MAP3K90.64142766
87MAP3K70.62843062
88TXK0.62116595
89INSR0.61831602
90CDK140.61680668
91NLK0.61508096
92ARAF0.61486160
93DYRK30.61448069
94CDK180.59242268
95RPS6KA40.58865051
96DAPK30.58452201
97CDK11A0.57666487
98NME10.57493572
99ADRBK10.55746495
100STK240.55685782
101PTK60.53929704
102DYRK1A0.53530723
103CHUK0.51797846
104MAP2K10.51069101
105FGR0.50958804
106HIPK20.50140498
107MAPK120.49851317
108PDPK10.49753760
109MAPKAPK20.49751900
110FGFR10.48006854
111PDK20.47887768
112MAP3K40.47690462
113RIPK40.47525783
114NEK90.47370769
115PIM10.46463269
116KIT0.46256646
117PAK60.45719467
118STK100.45378601
119NTRK10.45359460
120PRKD20.43186090
121PRPF4B0.43104366
122MET0.42902362
123SRC0.42754398
124PRKCE0.42581160
125MAPK70.41465524
126PRKAA20.40466502
127FES0.40093635
128LYN0.40093354
129RET0.39424863
130MAP4K10.38671576
131ABL10.37922178
132DYRK1B0.37238919
133MARK20.36802427
134INSRR0.36291506
135ROCK20.35322812
136CDK50.34380143
137LCK0.33726601
138PRKG20.33696760
139RPS6KA20.33429685
140ROCK10.32873315
141MAP3K130.32709596
142MINK10.32638909
143MAP2K70.31967499
144MAP2K40.31652884
145TAOK20.31315107
146CAMK40.29834296
147KSR20.29322721
148HCK0.28649656
149PKN10.27031005
150PAK10.26800801
151SYK0.25879594

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.56879936
2Malaria_Homo sapiens_hsa051443.89087951
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.60390127
4Protein digestion and absorption_Homo sapiens_hsa049742.41287773
5Focal adhesion_Homo sapiens_hsa045102.35762852
6Prion diseases_Homo sapiens_hsa050202.34858557
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05350825
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.93184758
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.83641758
10TNF signaling pathway_Homo sapiens_hsa046681.82119294
11Other glycan degradation_Homo sapiens_hsa005111.81861677
12Amoebiasis_Homo sapiens_hsa051461.78235466
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77150416
14Dilated cardiomyopathy_Homo sapiens_hsa054141.66099117
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58823719
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.54080924
17Lysosome_Homo sapiens_hsa041421.53795900
18Cocaine addiction_Homo sapiens_hsa050301.51731804
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50709131
20African trypanosomiasis_Homo sapiens_hsa051431.50664562
21Complement and coagulation cascades_Homo sapiens_hsa046101.50073457
22Graft-versus-host disease_Homo sapiens_hsa053321.40962661
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.37518379
24Proteoglycans in cancer_Homo sapiens_hsa052051.35100934
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33332801
26Allograft rejection_Homo sapiens_hsa053301.31862857
27Estrogen signaling pathway_Homo sapiens_hsa049151.30640509
28Asthma_Homo sapiens_hsa053101.30226800
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.30027468
30Osteoclast differentiation_Homo sapiens_hsa043801.29936445
31Phagosome_Homo sapiens_hsa041451.28081475
32Hematopoietic cell lineage_Homo sapiens_hsa046401.26244654
33Toxoplasmosis_Homo sapiens_hsa051451.25405128
34TGF-beta signaling pathway_Homo sapiens_hsa043501.25283411
35Bladder cancer_Homo sapiens_hsa052191.25221617
36Amphetamine addiction_Homo sapiens_hsa050311.22942642
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21770185
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16576519
39Mineral absorption_Homo sapiens_hsa049781.12333140
40GnRH signaling pathway_Homo sapiens_hsa049121.09847890
41Rheumatoid arthritis_Homo sapiens_hsa053231.09369911
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06155096
43Measles_Homo sapiens_hsa051621.04201111
44Legionellosis_Homo sapiens_hsa051341.02301040
45Type II diabetes mellitus_Homo sapiens_hsa049301.02183484
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.01826188
47Renin secretion_Homo sapiens_hsa049241.00858024
48Fatty acid biosynthesis_Homo sapiens_hsa000610.99128810
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98874614
50MAPK signaling pathway_Homo sapiens_hsa040100.98535122
51Leishmaniasis_Homo sapiens_hsa051400.98120556
52Dorso-ventral axis formation_Homo sapiens_hsa043200.97013801
53Insulin resistance_Homo sapiens_hsa049310.96482606
54Small cell lung cancer_Homo sapiens_hsa052220.96347912
55Pertussis_Homo sapiens_hsa051330.94592314
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90876432
57Sphingolipid metabolism_Homo sapiens_hsa006000.90734685
58Shigellosis_Homo sapiens_hsa051310.89902212
59MicroRNAs in cancer_Homo sapiens_hsa052060.87318473
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87244196
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86931167
62Staphylococcus aureus infection_Homo sapiens_hsa051500.86359361
63Oxytocin signaling pathway_Homo sapiens_hsa049210.85688355
64Gap junction_Homo sapiens_hsa045400.85428543
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81660516
66Chemokine signaling pathway_Homo sapiens_hsa040620.81579088
67Morphine addiction_Homo sapiens_hsa050320.81528887
68Axon guidance_Homo sapiens_hsa043600.80587948
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80443619
70Autoimmune thyroid disease_Homo sapiens_hsa053200.80323773
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80291756
72Acute myeloid leukemia_Homo sapiens_hsa052210.79281398
73Nicotine addiction_Homo sapiens_hsa050330.78813370
74Hedgehog signaling pathway_Homo sapiens_hsa043400.78789783
75Herpes simplex infection_Homo sapiens_hsa051680.78011825
76Circadian entrainment_Homo sapiens_hsa047130.76573878
77Salmonella infection_Homo sapiens_hsa051320.75333795
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74106178
79VEGF signaling pathway_Homo sapiens_hsa043700.74023699
80Platelet activation_Homo sapiens_hsa046110.72208197
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71792887
82cAMP signaling pathway_Homo sapiens_hsa040240.71357652
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.69691140
84GABAergic synapse_Homo sapiens_hsa047270.69658442
85Calcium signaling pathway_Homo sapiens_hsa040200.69381430
86Rap1 signaling pathway_Homo sapiens_hsa040150.69184146
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68418986
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67728582
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67486148
90Pathways in cancer_Homo sapiens_hsa052000.67449369
91Basal cell carcinoma_Homo sapiens_hsa052170.66263545
92Hippo signaling pathway_Homo sapiens_hsa043900.65541500
93Adherens junction_Homo sapiens_hsa045200.64475894
94Melanogenesis_Homo sapiens_hsa049160.64340615
95Synaptic vesicle cycle_Homo sapiens_hsa047210.63961608
96Dopaminergic synapse_Homo sapiens_hsa047280.63507534
97Cholinergic synapse_Homo sapiens_hsa047250.62859292
98Tuberculosis_Homo sapiens_hsa051520.61688446
99Prolactin signaling pathway_Homo sapiens_hsa049170.61559926
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60974548
101HIF-1 signaling pathway_Homo sapiens_hsa040660.60915108
102Salivary secretion_Homo sapiens_hsa049700.60063188
103Long-term potentiation_Homo sapiens_hsa047200.59912252
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.59597188
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.58263088
106Chronic myeloid leukemia_Homo sapiens_hsa052200.58167655
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57450876
108Type I diabetes mellitus_Homo sapiens_hsa049400.57411746
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57225112
110Circadian rhythm_Homo sapiens_hsa047100.56644992
111FoxO signaling pathway_Homo sapiens_hsa040680.56523579
112PPAR signaling pathway_Homo sapiens_hsa033200.56273237
113ErbB signaling pathway_Homo sapiens_hsa040120.56023494
114Melanoma_Homo sapiens_hsa052180.55556905
115Glioma_Homo sapiens_hsa052140.55538827
116Hepatitis B_Homo sapiens_hsa051610.55506240
117B cell receptor signaling pathway_Homo sapiens_hsa046620.55382184
118Influenza A_Homo sapiens_hsa051640.55079527
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54878822
120Taste transduction_Homo sapiens_hsa047420.53675183
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52631958
122Gastric acid secretion_Homo sapiens_hsa049710.51698529
123Prostate cancer_Homo sapiens_hsa052150.51481953
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51069104
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50728443
126Viral myocarditis_Homo sapiens_hsa054160.50524758
127Apoptosis_Homo sapiens_hsa042100.50312455
128Ras signaling pathway_Homo sapiens_hsa040140.50248790
129Hepatitis C_Homo sapiens_hsa051600.50030247
130Insulin secretion_Homo sapiens_hsa049110.49445449
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.49099515
132Wnt signaling pathway_Homo sapiens_hsa043100.48918325
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46812063
134HTLV-I infection_Homo sapiens_hsa051660.46462052
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.45959354
136T cell receptor signaling pathway_Homo sapiens_hsa046600.41270720
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35861838
138Endocytosis_Homo sapiens_hsa041440.35661123
139Ovarian steroidogenesis_Homo sapiens_hsa049130.35401066
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32406019
141mTOR signaling pathway_Homo sapiens_hsa041500.31950780
142Sulfur metabolism_Homo sapiens_hsa009200.31430048
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29992501
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29826057
145Notch signaling pathway_Homo sapiens_hsa043300.29592970
146Pancreatic cancer_Homo sapiens_hsa052120.29314877
147Galactose metabolism_Homo sapiens_hsa000520.28546076
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28498646

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