HAPLN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.12090228
2synaptic vesicle maturation (GO:0016188)5.92846902
3neuronal action potential propagation (GO:0019227)5.66074771
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.57189734
5locomotory exploration behavior (GO:0035641)5.53205359
6synaptic vesicle exocytosis (GO:0016079)5.42314933
7glutamate secretion (GO:0014047)5.35474756
8regulation of synaptic vesicle exocytosis (GO:2000300)5.23686575
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02197605
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.94244361
11neurotransmitter secretion (GO:0007269)4.80329123
12vocalization behavior (GO:0071625)4.80067175
13regulation of synaptic vesicle transport (GO:1902803)4.72475665
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.58135627
15amino acid import (GO:0043090)4.55240149
16neuromuscular process controlling posture (GO:0050884)4.48665438
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.44339719
18regulation of glutamate receptor signaling pathway (GO:1900449)4.39331630
19regulation of neuronal synaptic plasticity (GO:0048168)4.22633135
20cellular potassium ion homeostasis (GO:0030007)4.22145318
21positive regulation of dendritic spine development (GO:0060999)4.17851570
22gamma-aminobutyric acid transport (GO:0015812)4.17651827
23negative regulation of dendrite morphogenesis (GO:0050774)4.13399164
24exploration behavior (GO:0035640)4.10205388
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.09348051
26synaptic transmission, glutamatergic (GO:0035249)4.04316647
27glutamate receptor signaling pathway (GO:0007215)3.99167012
28positive regulation of dendritic spine morphogenesis (GO:0061003)3.97383000
29sodium ion export (GO:0071436)3.96575092
30regulation of voltage-gated calcium channel activity (GO:1901385)3.92473742
31cerebellar Purkinje cell differentiation (GO:0021702)3.90936917
32neurotransmitter transport (GO:0006836)3.90515144
33regulation of synapse maturation (GO:0090128)3.89569503
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.88128180
35protein localization to synapse (GO:0035418)3.87320016
36central nervous system myelination (GO:0022010)3.84627048
37axon ensheathment in central nervous system (GO:0032291)3.84627048
38postsynaptic membrane organization (GO:0001941)3.82858704
39positive regulation of neurotransmitter transport (GO:0051590)3.80958357
40positive regulation of neurotransmitter secretion (GO:0001956)3.80565594
41neuron-neuron synaptic transmission (GO:0007270)3.79528854
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74436111
43long-term memory (GO:0007616)3.74416794
44glycine transport (GO:0015816)3.73334019
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71133108
46proline transport (GO:0015824)3.69674406
47activation of protein kinase A activity (GO:0034199)3.67596743
48acidic amino acid transport (GO:0015800)3.62619319
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.59214001
50regulation of neurotransmitter levels (GO:0001505)3.57742254
51neurotransmitter uptake (GO:0001504)3.51057142
52neuron cell-cell adhesion (GO:0007158)3.50889348
53layer formation in cerebral cortex (GO:0021819)3.50533318
54positive regulation of membrane potential (GO:0045838)3.48345577
55cell communication by electrical coupling (GO:0010644)3.46085161
56synaptic vesicle endocytosis (GO:0048488)3.45720983
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44745558
58chemosensory behavior (GO:0007635)3.42419284
59regulation of dendritic spine development (GO:0060998)3.41129422
60regulation of synaptic plasticity (GO:0048167)3.39717686
61dendritic spine morphogenesis (GO:0060997)3.32287371
62cerebellar Purkinje cell layer development (GO:0021680)3.31209588
63regulation of neurotransmitter secretion (GO:0046928)3.30529471
64regulation of postsynaptic membrane potential (GO:0060078)3.30202513
65regulation of vesicle fusion (GO:0031338)3.28485726
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.27340873
67long-term synaptic potentiation (GO:0060291)3.26616298
68neuromuscular process controlling balance (GO:0050885)3.26363255
69L-glutamate transport (GO:0015813)3.25805236
70regulation of synapse structural plasticity (GO:0051823)3.25788753
71detection of calcium ion (GO:0005513)3.24215484
72transmission of nerve impulse (GO:0019226)3.21413214
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18706618
74neurotransmitter-gated ion channel clustering (GO:0072578)3.18034823
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.17590322
76positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.17157011
77neuromuscular synaptic transmission (GO:0007274)3.15098453
78vesicle docking involved in exocytosis (GO:0006904)3.14455039
79cytoskeletal anchoring at plasma membrane (GO:0007016)3.14439739
80cell communication involved in cardiac conduction (GO:0086065)3.13135947
81dicarboxylic acid transport (GO:0006835)3.12961558
82regulation of ARF protein signal transduction (GO:0032012)3.11685412
83membrane depolarization during action potential (GO:0086010)3.10037064
84potassium ion import (GO:0010107)3.09673125
85L-amino acid import (GO:0043092)3.06787935
86serotonin metabolic process (GO:0042428)3.06522803
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06374884
88vesicle transport along microtubule (GO:0047496)3.06200527
89innervation (GO:0060384)3.05976369
90regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.04362777
91cerebellar granule cell differentiation (GO:0021707)3.03001336
92regulation of calcium ion-dependent exocytosis (GO:0017158)3.02740399
93regulation of neurotransmitter transport (GO:0051588)3.01666159
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00778069
95long term synaptic depression (GO:0060292)2.99467894
96neuron recognition (GO:0008038)2.96769157
97positive regulation of synapse maturation (GO:0090129)2.94965224
98signal release (GO:0023061)2.93281052
99synaptic transmission (GO:0007268)2.92118955
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91426043
101neuromuscular process (GO:0050905)2.90956504
102membrane depolarization (GO:0051899)2.90895456
103calcium ion-dependent exocytosis (GO:0017156)2.89747897
104potassium ion homeostasis (GO:0055075)2.87440286
105regulation of dendritic spine morphogenesis (GO:0061001)2.87305884
106neuronal ion channel clustering (GO:0045161)2.86924220
107regulation of synaptic transmission (GO:0050804)2.84906869
108positive regulation of exocytosis (GO:0045921)2.84095261
109response to pheromone (GO:0019236)2.83306384
110regulation of synaptic transmission, glutamatergic (GO:0051966)2.83267349
111regulation of exocytosis (GO:0017157)2.83021817
112cell differentiation in hindbrain (GO:0021533)2.81474817
113adult walking behavior (GO:0007628)2.79488171
114cellular sodium ion homeostasis (GO:0006883)2.78785922
115dendritic spine organization (GO:0097061)2.78589719
116synaptic vesicle transport (GO:0048489)2.76910172
117establishment of synaptic vesicle localization (GO:0097480)2.76910172
118membrane hyperpolarization (GO:0060081)2.74420056
119suckling behavior (GO:0001967)2.74236081
120positive regulation of synaptic transmission (GO:0050806)2.73743502
121G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.72508919
122dendrite morphogenesis (GO:0048813)2.72190713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.13072180
2REST_21632747_ChIP-Seq_MESCs_Mouse3.06962741
3GBX2_23144817_ChIP-Seq_PC3_Human3.06393862
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03238023
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03214666
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86252921
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.74405736
8DROSHA_22980978_ChIP-Seq_HELA_Human2.63582568
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63209200
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63209200
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63121616
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59455474
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58696410
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.52495712
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48221172
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40965001
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33367769
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.20352149
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18614478
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.17861184
21* EZH2_27304074_Chip-Seq_ESCs_Mouse2.12632372
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06163738
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.05740006
24* EED_16625203_ChIP-ChIP_MESCs_Mouse2.05116593
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99713074
26* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93447668
27* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91833798
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.80303774
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73693324
30SMAD4_21799915_ChIP-Seq_A2780_Human1.59552313
31ZNF274_21170338_ChIP-Seq_K562_Hela1.56185592
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55141135
33* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54315502
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51002099
35RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49840439
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48134433
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45496041
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39472674
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35462530
40AR_21572438_ChIP-Seq_LNCaP_Human1.35374361
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34136638
42TAF15_26573619_Chip-Seq_HEK293_Human1.31970624
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31798416
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28285749
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.27895351
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25913387
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25264913
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.25028013
49AR_19668381_ChIP-Seq_PC3_Human1.24974114
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24454559
51STAT3_23295773_ChIP-Seq_U87_Human1.20940876
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19580904
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18312687
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18295434
55* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17631249
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17113429
57KDM2B_26808549_Chip-Seq_K562_Human1.16610623
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15765840
59AR_25329375_ChIP-Seq_VCAP_Human1.14607764
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14358806
61P300_19829295_ChIP-Seq_ESCs_Human1.10250965
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08980142
63* LXR_22292898_ChIP-Seq_THP-1_Human1.08914962
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.06599288
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05673012
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04343076
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03624727
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.03216884
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02911724
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02193880
71TCF4_23295773_ChIP-Seq_U87_Human1.01572709
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01171155
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01123834
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00900722
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00432304
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00417170
77DPY_21335234_ChIP-Seq_ESCs_Mouse1.00384516
78* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00090282
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97852993
80OCT4_19829295_ChIP-Seq_ESCs_Human0.97769995
81SMAD3_21741376_ChIP-Seq_ESCs_Human0.96146146
82CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95891480
83* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95615973
84* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95564896
85RXR_22108803_ChIP-Seq_LS180_Human0.94373269
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94316931
87YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94246209
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92703494
89IGF1R_20145208_ChIP-Seq_DFB_Human0.92646470
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92126063
91* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92034064
92RING1B_27294783_Chip-Seq_NPCs_Mouse0.90495436
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.90321583
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90163262
95* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89399575
96P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89229022
97SMC4_20622854_ChIP-Seq_HELA_Human0.88770714
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.88749796
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88055335
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88021199
101RUNX2_22187159_ChIP-Seq_PCA_Human0.87324042
102BCAT_22108803_ChIP-Seq_LS180_Human0.87277230
103BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87052684
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86516422
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86434546
106RNF2_27304074_Chip-Seq_NSC_Mouse0.86222435
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86122874
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.84382369
109CTCF_27219007_Chip-Seq_Bcells_Human0.84374369
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83879473
111SMAD4_21741376_ChIP-Seq_EPCs_Human0.83687706
112KLF4_19829295_ChIP-Seq_ESCs_Human0.83565327
113GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83372785
114AHR_22903824_ChIP-Seq_MCF-7_Human0.83352941
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82496362
116CREB1_26743006_Chip-Seq_LNCaP_Human0.82049585
117EGR1_19032775_ChIP-ChIP_M12_Human0.81527238
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.81063125
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80470073
120RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80009843
121* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78763520
122MYC_19915707_ChIP-ChIP_AK7_Human0.78241738
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78096248
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77403073
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76765320
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76547171
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.76321886
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.74905455
129SMAD4_21741376_ChIP-Seq_ESCs_Human0.74312652
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72605209
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.72603811
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.71648193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.35436841
2MP0003880_abnormal_central_pattern4.55830391
3MP0003635_abnormal_synaptic_transmissio4.12929075
4MP0004270_analgesia3.59120142
5MP0009046_muscle_twitch3.33141662
6MP0009745_abnormal_behavioral_response3.29256583
7MP0002064_seizures3.25533053
8MP0002063_abnormal_learning/memory/cond3.11039590
9MP0001968_abnormal_touch/_nociception2.78114329
10MP0002272_abnormal_nervous_system2.74837824
11MP0002572_abnormal_emotion/affect_behav2.60147580
12MP0002734_abnormal_mechanical_nocicepti2.49362460
13MP0001501_abnormal_sleep_pattern2.42266295
14MP0009780_abnormal_chondrocyte_physiolo2.40814342
15MP0001486_abnormal_startle_reflex2.35303731
16MP0002909_abnormal_adrenal_gland2.34356775
17MP0005423_abnormal_somatic_nervous2.27754234
18MP0008569_lethality_at_weaning2.17458776
19MP0003329_amyloid_beta_deposits2.15595347
20MP0001440_abnormal_grooming_behavior2.12433490
21MP0002736_abnormal_nociception_after2.11732850
22MP0002067_abnormal_sensory_capabilities2.02165265
23MP0002733_abnormal_thermal_nociception1.92391404
24MP0001970_abnormal_pain_threshold1.85472652
25MP0002735_abnormal_chemical_nociception1.82939393
26MP0005646_abnormal_pituitary_gland1.80718127
27MP0004858_abnormal_nervous_system1.75295408
28MP0003283_abnormal_digestive_organ1.68983402
29MP0002184_abnormal_innervation1.64724854
30MP0004811_abnormal_neuron_physiology1.64408966
31MP0003879_abnormal_hair_cell1.64113210
32MP0002822_catalepsy1.63321988
33MP0002557_abnormal_social/conspecific_i1.60288644
34MP0000955_abnormal_spinal_cord1.59722061
35MP0000013_abnormal_adipose_tissue1.58244359
36MP0004142_abnormal_muscle_tone1.56011557
37MP0005386_behavior/neurological_phenoty1.54991354
38MP0004924_abnormal_behavior1.54991354
39MP0003123_paternal_imprinting1.54985587
40MP0004043_abnormal_pH_regulation1.52933839
41MP0004147_increased_porphyrin_level1.48736517
42MP0003633_abnormal_nervous_system1.47119842
43MP0006276_abnormal_autonomic_nervous1.43204867
44MP0002066_abnormal_motor_capabilities/c1.43119776
45MP0003122_maternal_imprinting1.39775311
46MP0002837_dystrophic_cardiac_calcinosis1.37275199
47MP0004885_abnormal_endolymph1.37171057
48MP0001502_abnormal_circadian_rhythm1.35357418
49MP0004145_abnormal_muscle_electrophysio1.29948987
50MP0001984_abnormal_olfaction1.27940766
51MP0003787_abnormal_imprinting1.27813469
52MP0002882_abnormal_neuron_morphology1.27017840
53MP0010386_abnormal_urinary_bladder1.25554130
54MP0005645_abnormal_hypothalamus_physiol1.22489148
55MP0000778_abnormal_nervous_system1.20788975
56MP0003631_nervous_system_phenotype1.20283384
57MP0008961_abnormal_basal_metabolism1.14004711
58MP0005535_abnormal_body_temperature1.13826774
59MP0002229_neurodegeneration1.11726454
60MP0000604_amyloidosis1.04716516
61MP0003690_abnormal_glial_cell1.04463354
62MP0008877_abnormal_DNA_methylation1.01049505
63MP0002069_abnormal_eating/drinking_beha0.97376049
64MP0002693_abnormal_pancreas_physiology0.95422740
65MP0003172_abnormal_lysosome_physiology0.94672272
66MP0002152_abnormal_brain_morphology0.92338012
67MP0002876_abnormal_thyroid_physiology0.91538779
68MP0008872_abnormal_physiological_respon0.90860335
69MP0003632_abnormal_nervous_system0.90827210
70MP0000920_abnormal_myelination0.90330150
71MP0001346_abnormal_lacrimal_gland0.88219807
72MP0005379_endocrine/exocrine_gland_phen0.86060337
73MP0003183_abnormal_peptide_metabolism0.85566367
74MP0001944_abnormal_pancreas_morphology0.85236260
75MP0003634_abnormal_glial_cell0.84840379
76MP0001905_abnormal_dopamine_level0.83229086
77MP0003075_altered_response_to0.82518172
78MP0008874_decreased_physiological_sensi0.80175005
79MP0003195_calcinosis0.79875618
80MP0000566_synostosis0.78790146
81MP0002078_abnormal_glucose_homeostasis0.77893832
82MP0001177_atelectasis0.76850878
83MP0000751_myopathy0.76124028
84MP0004085_abnormal_heartbeat0.74548161
85MP0001529_abnormal_vocalization0.73791586
86MP0001765_abnormal_ion_homeostasis0.73717980
87MP0002877_abnormal_melanocyte_morpholog0.72868364
88MP0001963_abnormal_hearing_physiology0.72456022
89MP0009379_abnormal_foot_pigmentation0.70417581
90MP0004742_abnormal_vestibular_system0.69775288
91MP0005551_abnormal_eye_electrophysiolog0.67782900
92MP0005083_abnormal_biliary_tract0.66534747
93MP0005167_abnormal_blood-brain_barrier0.65896730
94MP0002638_abnormal_pupillary_reflex0.65510030
95MP0001986_abnormal_taste_sensitivity0.64009207
96MP0001348_abnormal_lacrimal_gland0.64002161
97MP0003137_abnormal_impulse_conducting0.63254497
98MP0003953_abnormal_hormone_level0.62567204
99MP0001299_abnormal_eye_distance/0.62321305
100MP0001188_hyperpigmentation0.62268245
101MP0001485_abnormal_pinna_reflex0.61812453
102MP0004233_abnormal_muscle_weight0.60583444
103MP0002090_abnormal_vision0.60071205
104MP0001664_abnormal_digestion0.59754314
105MP0004215_abnormal_myocardial_fiber0.59455768
106MP0003045_fibrosis0.58113812
107MP0000003_abnormal_adipose_tissue0.57982258
108MP0005166_decreased_susceptibility_to0.57835774
109MP0005448_abnormal_energy_balance0.57636764
110MP0004484_altered_response_of0.57082984
111MP0010769_abnormal_survival0.56526980
112MP0004510_myositis0.56053060
113MP0002752_abnormal_somatic_nervous0.54060458
114MP0010768_mortality/aging0.52971841
115MP0010770_preweaning_lethality0.52903851
116MP0002082_postnatal_lethality0.52903851
117MP0000579_abnormal_nail_morphology0.51971440
118MP0003956_abnormal_body_size0.51961564
119MP0003121_genomic_imprinting0.51460114
120MP0005409_darkened_coat_color0.48150641
121MP0002089_abnormal_postnatal_growth/wei0.47888083
122MP0003861_abnormal_nervous_system0.47519688
123MP0005623_abnormal_meninges_morphology0.47078466
124MP0002873_normal_phenotype0.46252194
125MP0000026_abnormal_inner_ear0.45018176
126MP0002169_no_abnormal_phenotype0.44923985

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.71349694
2Myokymia (HP:0002411)6.32340502
3Visual hallucinations (HP:0002367)5.83761632
4Focal seizures (HP:0007359)5.52348542
5Atonic seizures (HP:0010819)5.36606135
6Absence seizures (HP:0002121)4.59890505
7Febrile seizures (HP:0002373)4.54447272
8Action tremor (HP:0002345)4.49241060
9Progressive cerebellar ataxia (HP:0002073)4.42989902
10Epileptic encephalopathy (HP:0200134)4.42034781
11Generalized tonic-clonic seizures (HP:0002069)4.15199112
12Dialeptic seizures (HP:0011146)4.12381728
13Supranuclear gaze palsy (HP:0000605)3.92078256
14Cerebral hypomyelination (HP:0006808)3.38981345
15Dysdiadochokinesis (HP:0002075)3.34847633
16Gaze-evoked nystagmus (HP:0000640)3.33927567
17Impaired vibration sensation in the lower limbs (HP:0002166)3.33439589
18Dysmetria (HP:0001310)3.29180961
19Depression (HP:0000716)3.28769830
20Limb dystonia (HP:0002451)3.24889211
21Truncal ataxia (HP:0002078)3.15266422
22Anxiety (HP:0000739)3.11626396
23Obstructive sleep apnea (HP:0002870)3.11211697
24Postural instability (HP:0002172)3.08937417
25Poor eye contact (HP:0000817)3.08166324
26Ankle clonus (HP:0011448)3.05968021
27Impaired smooth pursuit (HP:0007772)3.05947413
28Impaired social interactions (HP:0000735)2.96359389
29Abnormal social behavior (HP:0012433)2.96359389
30Abnormal eating behavior (HP:0100738)2.94929550
31Status epilepticus (HP:0002133)2.93575910
32Ventricular fibrillation (HP:0001663)2.90206452
33Scanning speech (HP:0002168)2.89339880
34Hemiplegia (HP:0002301)2.88242977
35Papilledema (HP:0001085)2.84930415
36Intention tremor (HP:0002080)2.81300490
37Abnormality of the lower motor neuron (HP:0002366)2.78984578
38Epileptiform EEG discharges (HP:0011182)2.78293924
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.75570173
40EEG with generalized epileptiform discharges (HP:0011198)2.73054402
41Amblyopia (HP:0000646)2.69749404
42Akinesia (HP:0002304)2.67803807
43Urinary bladder sphincter dysfunction (HP:0002839)2.67026623
44Broad-based gait (HP:0002136)2.65624923
45Agitation (HP:0000713)2.63674766
46Hypsarrhythmia (HP:0002521)2.61810816
47Sleep apnea (HP:0010535)2.60680055
48Pheochromocytoma (HP:0002666)2.60402390
49Hemiparesis (HP:0001269)2.59606050
50Abnormality of ocular smooth pursuit (HP:0000617)2.57487286
51Hyperventilation (HP:0002883)2.52139384
52Dysmetric saccades (HP:0000641)2.51773147
53Genetic anticipation (HP:0003743)2.51542082
54Neurofibrillary tangles (HP:0002185)2.51032143
55Spastic gait (HP:0002064)2.50797218
56Bradykinesia (HP:0002067)2.50052412
57Cerebral inclusion bodies (HP:0100314)2.47573475
58Bundle branch block (HP:0011710)2.44355915
59Diplopia (HP:0000651)2.37372591
60Abnormality of binocular vision (HP:0011514)2.37372591
61Urinary urgency (HP:0000012)2.33966947
62Generalized myoclonic seizures (HP:0002123)2.29644016
63Confusion (HP:0001289)2.28661029
64Impaired vibratory sensation (HP:0002495)2.27335845
65Apathy (HP:0000741)2.26659632
66Neuroendocrine neoplasm (HP:0100634)2.25267588
67Excessive salivation (HP:0003781)2.24858925
68Drooling (HP:0002307)2.24858925
69Peripheral hypomyelination (HP:0007182)2.24807687
70Choreoathetosis (HP:0001266)2.24329691
71Mutism (HP:0002300)2.23420062
72Torticollis (HP:0000473)2.20266907
73Spastic tetraparesis (HP:0001285)2.19850359
74Focal dystonia (HP:0004373)2.19498032
75Postural tremor (HP:0002174)2.19268079
76Hyperinsulinemic hypoglycemia (HP:0000825)2.13037038
77Progressive inability to walk (HP:0002505)2.11658938
78Tetraplegia (HP:0002445)2.09383387
79Megalencephaly (HP:0001355)2.09112871
80Abnormality of saccadic eye movements (HP:0000570)2.08843695
81Gait ataxia (HP:0002066)2.08702741
82CNS hypomyelination (HP:0003429)2.06584454
83Global brain atrophy (HP:0002283)2.05922518
84Absent speech (HP:0001344)2.05133762
85Diminished motivation (HP:0000745)2.05019770
86Psychosis (HP:0000709)2.04915225
87Neuronal loss in central nervous system (HP:0002529)2.04737218
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04286620
89Degeneration of the lateral corticospinal tracts (HP:0002314)2.04286620
90Termporal pattern (HP:0011008)2.02314741
91Insidious onset (HP:0003587)2.02314741
92Failure to thrive in infancy (HP:0001531)2.01904188
93Clonus (HP:0002169)2.01452599
94Delusions (HP:0000746)2.01294777
95Stereotypic behavior (HP:0000733)1.96322050
96Hypoglycemic seizures (HP:0002173)1.94182971
97Aplasia involving bones of the upper limbs (HP:0009823)1.93025960
98Aplasia of the phalanges of the hand (HP:0009802)1.93025960
99Aplasia involving bones of the extremities (HP:0009825)1.93025960
100Resting tremor (HP:0002322)1.92153203
101Cortical visual impairment (HP:0100704)1.91561645
102Morphological abnormality of the pyramidal tract (HP:0002062)1.91094140
103Insomnia (HP:0100785)1.90479982
104Bronchomalacia (HP:0002780)1.90407941
105Craniofacial dystonia (HP:0012179)1.88837972
106Limb ataxia (HP:0002070)1.88390683
107Split foot (HP:0001839)1.87355662
108Lower limb muscle weakness (HP:0007340)1.86916821
109Rigidity (HP:0002063)1.85821376
110Heart block (HP:0012722)1.85235445
111Abnormality of the corticospinal tract (HP:0002492)1.84215342
112Annular pancreas (HP:0001734)1.82492238
113Lower limb amyotrophy (HP:0007210)1.80941086
114Spinal canal stenosis (HP:0003416)1.80581421
115Memory impairment (HP:0002354)1.80031712
116Dementia (HP:0000726)1.78872015
117Rapidly progressive (HP:0003678)1.76024280
118Type II lissencephaly (HP:0007260)1.72366309
119Polyphagia (HP:0002591)1.71076439
120Increased circulating renin level (HP:0000848)1.71040723
121Lower limb asymmetry (HP:0100559)1.69794780
122Restlessness (HP:0000711)1.68370366
123Abnormality of calcium-phosphate metabolism (HP:0100530)1.66990967
124Incomplete penetrance (HP:0003829)1.66807808
125Abnormality of the periventricular white matter (HP:0002518)1.66134494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.91042146
2MAP3K93.79263900
3EPHA43.46118477
4MAP3K43.25007014
5PRKD33.09669191
6MINK12.71558852
7MAP2K72.57572140
8MAP2K42.35612117
9PAK62.31412033
10DAPK22.27314437
11CAMKK12.16509850
12KSR22.13478652
13NTRK12.13428667
14RIPK42.12260916
15MAP3K122.04572335
16CAMKK21.78339873
17STK381.76503395
18MARK11.64343787
19MAP3K21.62009756
20NTRK21.56155339
21CDK191.51479007
22ARAF1.48300354
23CDK51.46143565
24GRK51.40005395
25PRKCG1.35811591
26PLK21.35635828
27PNCK1.34914284
28DAPK11.34610626
29UHMK11.32972048
30KSR11.24418979
31PRKCH1.20299049
32WNK11.17414366
33PINK11.17075652
34INSRR1.15034996
35SCYL21.14621056
36MAP3K131.12965332
37BMPR21.06964980
38FES1.06307800
39TYRO31.05996431
40MAP3K10.98359469
41PRPF4B0.97501754
42RET0.95071330
43SGK4940.93426497
44SGK2230.93426497
45CAMK2A0.90488239
46STK110.89538682
47SIK20.89492342
48CAMK10.88457144
49CASK0.86765269
50TNIK0.86388896
51TNK20.85506747
52CAMK2B0.85153241
53PRKG20.84929686
54PAK30.84345113
55MAPK130.83515270
56CDC42BPA0.81983762
57ALK0.81407822
58PDK10.77072744
59MAP3K110.75959848
60PDPK10.75625011
61LMTK20.75430020
62CDK150.73577363
63CDK180.73227068
64DAPK30.72891770
65TAOK10.71961794
66OXSR10.71602041
67CDK140.70866345
68SGK20.70551417
69LATS20.70487798
70FGFR20.70048994
71CAMK2G0.69568513
72SGK30.69057925
73FER0.67652544
74LIMK10.65354205
75RAF10.65324083
76MAPK120.65311455
77RIPK10.63710101
78NME10.63062364
79CDK11A0.61798379
80TESK10.61385314
81CAMK2D0.60860645
82PTK2B0.59618478
83SGK10.59394390
84CAMK1G0.58620067
85BRSK10.57817026
86DYRK1A0.54547234
87PRKCE0.53815042
88NEK60.52658217
89RPS6KA30.52566669
90PHKG20.51711768
91PHKG10.51711768
92MAPK100.51483596
93HIPK20.49695054
94PKN10.49292737
95MAP2K10.45773578
96AKT30.45655694
97MARK20.44738323
98WNK40.43769060
99PRKCZ0.43244164
100PDGFRA0.40061742
101MAP3K70.40029716
102BRAF0.39845210
103ERBB20.39632679
104CAMK40.38959504
105ROCK20.35266746
106PRKD20.34808578
107PRKCA0.34186461
108CSNK1G20.32862709
109FYN0.32280887
110PRKG10.29581604
111PRKCB0.28775708
112TAOK20.28488911
113CSNK1E0.28440956
114PRKACA0.26675965
115SRC0.26582284
116DMPK0.25935588
117MAPK80.25036729
118ROCK10.24685959

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.48326672
2Synaptic vesicle cycle_Homo sapiens_hsa047213.40518585
3Long-term potentiation_Homo sapiens_hsa047202.71140519
4GABAergic synapse_Homo sapiens_hsa047272.63127323
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53166794
6Insulin secretion_Homo sapiens_hsa049112.49228603
7Circadian entrainment_Homo sapiens_hsa047132.47478780
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.46379969
9Glutamatergic synapse_Homo sapiens_hsa047242.41649108
10Amphetamine addiction_Homo sapiens_hsa050312.40819024
11Olfactory transduction_Homo sapiens_hsa047402.22368288
12Morphine addiction_Homo sapiens_hsa050322.18422343
13Salivary secretion_Homo sapiens_hsa049702.05769287
14Nitrogen metabolism_Homo sapiens_hsa009102.01271531
15Dopaminergic synapse_Homo sapiens_hsa047281.96630604
16Taste transduction_Homo sapiens_hsa047421.86645889
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86117014
18Gastric acid secretion_Homo sapiens_hsa049711.85309069
19Vitamin B6 metabolism_Homo sapiens_hsa007501.85100273
20Cholinergic synapse_Homo sapiens_hsa047251.71388661
21Long-term depression_Homo sapiens_hsa047301.63877237
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63314672
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63296205
24Collecting duct acid secretion_Homo sapiens_hsa049661.59916540
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53020742
26Type II diabetes mellitus_Homo sapiens_hsa049301.48899679
27Cocaine addiction_Homo sapiens_hsa050301.43955749
28Renin secretion_Homo sapiens_hsa049241.42928120
29Calcium signaling pathway_Homo sapiens_hsa040201.39313042
30Oxytocin signaling pathway_Homo sapiens_hsa049211.38423659
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36603667
32Pancreatic secretion_Homo sapiens_hsa049721.34807203
33Serotonergic synapse_Homo sapiens_hsa047261.34788977
34GnRH signaling pathway_Homo sapiens_hsa049121.31890701
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29898509
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27948537
37Vibrio cholerae infection_Homo sapiens_hsa051101.24368361
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22762554
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.21747706
40Estrogen signaling pathway_Homo sapiens_hsa049151.13576464
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13189197
42cAMP signaling pathway_Homo sapiens_hsa040241.11849207
43Gap junction_Homo sapiens_hsa045401.08117038
44Thyroid hormone synthesis_Homo sapiens_hsa049180.99414793
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98749042
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98022934
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95769274
48Glioma_Homo sapiens_hsa052140.94631899
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92272072
50Cardiac muscle contraction_Homo sapiens_hsa042600.89735053
51Melanogenesis_Homo sapiens_hsa049160.87342287
52Bile secretion_Homo sapiens_hsa049760.86330707
53Mineral absorption_Homo sapiens_hsa049780.82096520
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.81964016
55Type I diabetes mellitus_Homo sapiens_hsa049400.81157520
56Histidine metabolism_Homo sapiens_hsa003400.81040968
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79737469
58Glucagon signaling pathway_Homo sapiens_hsa049220.79525033
59Arginine and proline metabolism_Homo sapiens_hsa003300.78564542
60Dorso-ventral axis formation_Homo sapiens_hsa043200.77536957
61Arginine biosynthesis_Homo sapiens_hsa002200.75237636
62ErbB signaling pathway_Homo sapiens_hsa040120.75174294
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73826582
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.68695012
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67628388
66Oocyte meiosis_Homo sapiens_hsa041140.66956012
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65486632
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65049254
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.63296718
70Inositol phosphate metabolism_Homo sapiens_hsa005620.61490044
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58526943
72Prion diseases_Homo sapiens_hsa050200.57263474
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55434945
74Circadian rhythm_Homo sapiens_hsa047100.53639647
75Choline metabolism in cancer_Homo sapiens_hsa052310.53431496
76Alzheimers disease_Homo sapiens_hsa050100.50990934
77mTOR signaling pathway_Homo sapiens_hsa041500.49822051
78MAPK signaling pathway_Homo sapiens_hsa040100.49789534
79Protein digestion and absorption_Homo sapiens_hsa049740.49567497
80Axon guidance_Homo sapiens_hsa043600.49329292
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.48008043
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46684749
83VEGF signaling pathway_Homo sapiens_hsa043700.44158464
84Dilated cardiomyopathy_Homo sapiens_hsa054140.42219719
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41178599
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40107233
87Butanoate metabolism_Homo sapiens_hsa006500.39755625
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39594043
89Insulin signaling pathway_Homo sapiens_hsa049100.39364721
90Endocytosis_Homo sapiens_hsa041440.35533896
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.35018846
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33751806
93Oxidative phosphorylation_Homo sapiens_hsa001900.32722905
94Ras signaling pathway_Homo sapiens_hsa040140.31789661
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.30957441
96Fat digestion and absorption_Homo sapiens_hsa049750.27095799
97Fatty acid biosynthesis_Homo sapiens_hsa000610.26926109
98Rap1 signaling pathway_Homo sapiens_hsa040150.26481446
99Renin-angiotensin system_Homo sapiens_hsa046140.25801869
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25282709
101Wnt signaling pathway_Homo sapiens_hsa043100.24844296
102beta-Alanine metabolism_Homo sapiens_hsa004100.24733747
103Tight junction_Homo sapiens_hsa045300.24700328
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23452886
105Phenylalanine metabolism_Homo sapiens_hsa003600.23297328
106Ovarian steroidogenesis_Homo sapiens_hsa049130.23275772
107Lysosome_Homo sapiens_hsa041420.22417700
108Alcoholism_Homo sapiens_hsa050340.22237206
109Phototransduction_Homo sapiens_hsa047440.21772134
110Non-small cell lung cancer_Homo sapiens_hsa052230.20195408
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20165243
112African trypanosomiasis_Homo sapiens_hsa051430.19729366
113Sulfur metabolism_Homo sapiens_hsa009200.19197042
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18647949
115Biosynthesis of amino acids_Homo sapiens_hsa012300.17391108
116Vitamin digestion and absorption_Homo sapiens_hsa049770.15610965
117Glycerolipid metabolism_Homo sapiens_hsa005610.13609959
118AMPK signaling pathway_Homo sapiens_hsa041520.12587530

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