HAND2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)7.53327457
2sarcomere organization (GO:0045214)7.48941735
3endocardial cushion morphogenesis (GO:0003203)6.60423907
4* cardiac chamber formation (GO:0003207)6.45253323
5myofibril assembly (GO:0030239)6.32153069
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.79824472
7negative regulation of potassium ion transmembrane transport (GO:1901380)5.76565074
8mesenchyme morphogenesis (GO:0072132)5.75270977
9cardiac muscle cell development (GO:0055013)5.72564673
10enteric nervous system development (GO:0048484)5.67001676
11cardiac muscle contraction (GO:0060048)5.62016459
12* cardiac ventricle formation (GO:0003211)5.41635242
13cardiac cell development (GO:0055006)5.33815469
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.28470977
15exogenous drug catabolic process (GO:0042738)5.21285643
16arginine catabolic process (GO:0006527)5.10755656
17heart trabecula formation (GO:0060347)5.06672686
18cardiac muscle tissue morphogenesis (GO:0055008)5.00771275
19actin-myosin filament sliding (GO:0033275)5.00191016
20muscle filament sliding (GO:0030049)5.00191016
21plasma membrane repair (GO:0001778)4.98418160
22ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.94129635
23* adult heart development (GO:0007512)4.93731030
24ventricular cardiac muscle cell action potential (GO:0086005)4.92949214
25positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.86382928
26* cell migration involved in heart development (GO:0060973)4.80694688
27regulation of the force of heart contraction (GO:0002026)4.78446335
28regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.76484262
29regulation of actin filament-based movement (GO:1903115)4.72182190
30actomyosin structure organization (GO:0031032)4.69128893
31* negative regulation of striated muscle cell apoptotic process (GO:0010664)4.68676792
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.65584565
33regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.58033972
34tricarboxylic acid cycle (GO:0006099)4.57607152
35bundle of His cell to Purkinje myocyte communication (GO:0086069)4.55916706
36muscle tissue morphogenesis (GO:0060415)4.47502814
37regulation of cardioblast differentiation (GO:0051890)4.45065750
38actin-mediated cell contraction (GO:0070252)4.36193855
39cardiac muscle tissue development (GO:0048738)4.34033749
40* sympathetic nervous system development (GO:0048485)4.31187774
41dopaminergic neuron differentiation (GO:0071542)4.26548591
42embryonic heart tube development (GO:0035050)4.25026040
43negative regulation of dendrite morphogenesis (GO:0050774)4.24613469
44* negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.22544812
45cardiac muscle hypertrophy (GO:0003300)4.22312313
46drug catabolic process (GO:0042737)4.19889702
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.19555427
48outflow tract septum morphogenesis (GO:0003148)4.19426101
49striated muscle contraction (GO:0006941)4.18620034
50regulation of striated muscle contraction (GO:0006942)4.17898901
51negative regulation of potassium ion transport (GO:0043267)4.14963597
52neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.05393339
53positive regulation of cardiac muscle cell proliferation (GO:0060045)4.00348594
54heart process (GO:0003015)3.96712959
55heart contraction (GO:0060047)3.96712959
56striated muscle hypertrophy (GO:0014897)3.94887890
57cell communication involved in cardiac conduction (GO:0086065)3.94076163
58regulation of sarcomere organization (GO:0060297)3.92088606
59behavioral response to nicotine (GO:0035095)3.90202016
604-hydroxyproline metabolic process (GO:0019471)3.85047631
61regulation of relaxation of muscle (GO:1901077)3.82970361
62atrioventricular valve morphogenesis (GO:0003181)3.80213122
63regulation of cardiac muscle contraction (GO:0055117)3.80054561
64positive regulation of cardiac muscle tissue growth (GO:0055023)3.75986565
65regulation of membrane repolarization (GO:0060306)3.75905726
66cell migration in hindbrain (GO:0021535)3.74209619
67cell communication by electrical coupling (GO:0010644)3.73341281
68regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.68417333
69phenol-containing compound catabolic process (GO:0019336)3.65980827
70carnitine shuttle (GO:0006853)3.63333725
71cardiac septum morphogenesis (GO:0060411)3.60070151
72positive regulation of cardiac muscle tissue development (GO:0055025)3.59836157
73ventricular cardiac muscle cell development (GO:0055015)3.59026435
74* regulation of heart morphogenesis (GO:2000826)3.57871590
75cardiac muscle cell proliferation (GO:0060038)3.57837719
76atrial septum morphogenesis (GO:0060413)3.55289274
77regulation of skeletal muscle contraction (GO:0014819)3.55035602
78* regulation of striated muscle cell apoptotic process (GO:0010662)3.54569333
79muscle hypertrophy (GO:0014896)3.49707930
80regulation of cell communication by electrical coupling (GO:0010649)3.49181013
81relaxation of cardiac muscle (GO:0055119)3.48030656
82mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.46747593
83negative regulation of myotube differentiation (GO:0010832)3.46376332
84trabecula formation (GO:0060343)3.44874555
85heart valve morphogenesis (GO:0003179)3.44685280
86protein hydroxylation (GO:0018126)3.40025481
87positive regulation of heart growth (GO:0060421)3.39680459
88regulation of cardiac muscle cell contraction (GO:0086004)3.38853837
89oxygen transport (GO:0015671)3.38004510
90regulation of heart rate (GO:0002027)3.37008584
91cardiac right ventricle morphogenesis (GO:0003215)3.35779717
92regulation of heart contraction (GO:0008016)3.31336364
93peptidyl-proline hydroxylation (GO:0019511)3.30926758
94positive regulation of fatty acid beta-oxidation (GO:0032000)3.29728663
95ganglion development (GO:0061548)3.29707898
96cardiac muscle cell action potential involved in contraction (GO:0086002)3.25102730
97actin filament-based movement (GO:0030048)3.24729389
98behavioral response to ethanol (GO:0048149)3.24367645
99cardiac septum development (GO:0003279)3.23961773
100energy coupled proton transport, down electrochemical gradient (GO:0015985)3.23176376
101ATP synthesis coupled proton transport (GO:0015986)3.23176376
102regulation of cardiac muscle cell proliferation (GO:0060043)3.21826799
103regulation of fatty acid oxidation (GO:0046320)3.21671922
104adrenergic receptor signaling pathway (GO:0071875)3.21164337
105negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19945765
106regulation of cardiac muscle tissue development (GO:0055024)3.19454150
107response to parathyroid hormone (GO:0071107)3.17940136
108fatty acid transmembrane transport (GO:1902001)3.17042604
109cardiac muscle cell action potential (GO:0086001)3.16967059
110regulation of respiratory gaseous exchange (GO:0043576)3.16922973
111venous blood vessel morphogenesis (GO:0048845)3.15098851
112negative regulation of skeletal muscle tissue development (GO:0048642)3.11944908
113arginine metabolic process (GO:0006525)3.11134367
114positive regulation of heart contraction (GO:0045823)3.10439046
1152-oxoglutarate metabolic process (GO:0006103)3.07784951
116regulation of heart growth (GO:0060420)3.05575339
117response to inactivity (GO:0014854)3.04656081
118positive regulation of fatty acid oxidation (GO:0046321)3.03197596
119positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.03130660
120striated muscle cell development (GO:0055002)3.01416130
121cardiac muscle hypertrophy in response to stress (GO:0014898)2.99274551
122muscle hypertrophy in response to stress (GO:0003299)2.99274551
123cardiac muscle adaptation (GO:0014887)2.99274551
124cellular response to prostaglandin stimulus (GO:0071379)2.97839852
125regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.96945817
126body morphogenesis (GO:0010171)2.96945611
127regulation of cardiac muscle tissue growth (GO:0055021)2.95923701
128regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.95235742
129response to BMP (GO:0071772)2.95101829
130cellular response to BMP stimulus (GO:0071773)2.95101829
131* regulation of cardiac muscle cell apoptotic process (GO:0010665)2.94296573
132regulation of heart rate by cardiac conduction (GO:0086091)2.92364812
133mesoderm formation (GO:0001707)2.92026731
134norepinephrine metabolic process (GO:0042415)2.89201208
135regulation of ATPase activity (GO:0043462)2.88953374
136regulation of ATP catabolic process (GO:1903289)2.88953374
137regulation of muscle contraction (GO:0006937)2.88188984
138neuron projection extension involved in neuron projection guidance (GO:1902284)2.87555193
139axon extension involved in axon guidance (GO:0048846)2.87555193
140muscle cell fate commitment (GO:0042693)2.86764542
141endocardial cushion development (GO:0003197)2.86736571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.31263377
2EP300_21415370_ChIP-Seq_HL-1_Mouse3.49566868
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.33418344
4ZNF263_19887448_ChIP-Seq_K562_Human3.23762111
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.16520861
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00397151
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.00109587
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.91634904
9* TBX20_22328084_ChIP-Seq_HEART_Mouse2.87716537
10* TBX20_22080862_ChIP-Seq_HEART_Mouse2.87716537
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61884201
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.51060257
13* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.49297189
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40150980
15CLOCK_20551151_ChIP-Seq_293T_Human2.35134314
16RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.30887314
17GATA1_22025678_ChIP-Seq_K562_Human2.23250039
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21195943
19MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.14633756
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13547967
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.11950142
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.07798397
23* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.99482674
24* RNF2_27304074_Chip-Seq_ESCs_Mouse1.97844621
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96916168
26* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95880651
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87254232
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85685851
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.83672117
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.82281599
31LXR_22292898_ChIP-Seq_THP-1_Human1.80696823
32* RING1B_27294783_Chip-Seq_NPCs_Mouse1.73518638
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.71795356
34RXR_22158963_ChIP-Seq_LIVER_Mouse1.70470592
35* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70413081
36* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68204306
37* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68204306
38* CBX2_27304074_Chip-Seq_ESCs_Mouse1.66252781
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.65644413
40KDM2B_26808549_Chip-Seq_K562_Human1.65585127
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.64829088
42ISL1_27105846_Chip-Seq_CPCs_Mouse1.63908306
43KDM2B_26808549_Chip-Seq_DND41_Human1.62377762
44* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.59786550
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.58996647
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57874474
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56270642
48RACK7_27058665_Chip-Seq_MCF-7_Human1.55401328
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53962933
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53775292
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52473114
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50929259
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49263675
54* EZH2_27304074_Chip-Seq_ESCs_Mouse1.48903982
55* TP53_20018659_ChIP-ChIP_R1E_Mouse1.46911250
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46633298
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45368671
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44448138
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.44429330
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.43708040
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42813976
62CTCF_27219007_Chip-Seq_Bcells_Human1.42082983
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41349101
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39441152
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.39262769
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38173358
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35013061
68* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34929030
69* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34725310
70* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34680328
71* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33024071
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30720987
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30107405
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29442281
75* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28886561
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28072130
77DROSHA_22980978_ChIP-Seq_HELA_Human1.26012550
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24700230
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24683922
80ATF3_27146783_Chip-Seq_COLON_Human1.24485799
81* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23074137
82CREB1_26743006_Chip-Seq_LNCaP_Human1.22426634
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22321569
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21429093
85* EZH2_27294783_Chip-Seq_ESCs_Mouse1.20712752
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16485876
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15871539
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15843885
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.15652654
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.14755490
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.14295721
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14142686
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09591573
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08606034
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08438007
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07643200
97ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07551802
98* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07387065
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05446393
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05360030
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04670610
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.04028769
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03402659
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03075491
105TP63_22573176_ChIP-Seq_HFKS_Human1.02344825
106* RING1B_27294783_Chip-Seq_ESCs_Mouse1.02104135
107* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01168219
108EZH2_22144423_ChIP-Seq_EOC_Human1.00719648
109* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00096609
110ESR1_21235772_ChIP-Seq_MCF-7_Human0.99987336
111ZNF274_21170338_ChIP-Seq_K562_Hela0.98936344
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97889865
113WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97835825
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97555373
115GBX2_23144817_ChIP-Seq_PC3_Human0.96604855
116GATA1_19941826_ChIP-Seq_K562_Human0.96136479
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95926504
118* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95420562
119SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95363818
120OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94587759
121* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94550104
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94042559
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.94005122
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.93382202
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92246669
126TP53_23651856_ChIP-Seq_MEFs_Mouse0.89243774
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88706172
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.88459776
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87187456
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87098521
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84853892
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84259364
133GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83257244
134SMC3_22415368_ChIP-Seq_MEFs_Mouse0.80856805
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.80270503
136* RNF2_27304074_Chip-Seq_NSC_Mouse0.75604506
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.75513173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.72748238
2MP0003646_muscle_fatigue5.60352681
3MP0002837_dystrophic_cardiac_calcinosis5.59411398
4MP0000751_myopathy3.93137809
5MP0004036_abnormal_muscle_relaxation3.86403148
6MP0002009_preneoplasia3.47273492
7MP0004215_abnormal_myocardial_fiber3.37960330
8MP0005330_cardiomyopathy3.12243652
9MP0008775_abnormal_heart_ventricle3.02924843
10MP0002822_catalepsy2.94247532
11MP0000749_muscle_degeneration2.80903241
12MP0002127_abnormal_cardiovascular_syste2.67247377
13* MP0002972_abnormal_cardiac_muscle2.65761412
14MP0004233_abnormal_muscle_weight2.57553494
15* MP0006138_congestive_heart_failure2.47544916
16MP0003137_abnormal_impulse_conducting2.38425450
17* MP0001544_abnormal_cardiovascular_syste2.35804671
18* MP0005385_cardiovascular_system_phenoty2.35804671
19MP0004087_abnormal_muscle_fiber2.33054225
20* MP0010630_abnormal_cardiac_muscle2.28596740
21MP0003122_maternal_imprinting2.18583304
22MP0004484_altered_response_of2.11506843
23MP0005275_abnormal_skin_tensile2.09959108
24* MP0005620_abnormal_muscle_contractility2.08888773
25MP0002638_abnormal_pupillary_reflex2.04263852
26MP0003123_paternal_imprinting2.03841317
27MP0004085_abnormal_heartbeat2.00782272
28MP0004858_abnormal_nervous_system1.95414403
29MP0004130_abnormal_muscle_cell1.94699794
30MP0002653_abnormal_ependyma_morphology1.93934537
31MP0002269_muscular_atrophy1.87215191
32MP0000750_abnormal_muscle_regeneration1.78209066
33* MP0002106_abnormal_muscle_physiology1.77098746
34MP0003279_aneurysm1.58186786
35MP0003828_pulmonary_edema1.54160789
36MP0003221_abnormal_cardiomyocyte_apopto1.53852595
37MP0005623_abnormal_meninges_morphology1.50194295
38* MP0000759_abnormal_skeletal_muscle1.48846373
39* MP0003567_abnormal_fetal_cardiomyocyte1.46161832
40* MP0005369_muscle_phenotype1.42701149
41MP0000747_muscle_weakness1.37255112
42MP0004510_myositis1.36709676
43MP0003705_abnormal_hypodermis_morpholog1.31407109
44MP0002909_abnormal_adrenal_gland1.31180524
45MP0008438_abnormal_cutaneous_collagen1.29996117
46MP0005083_abnormal_biliary_tract1.25003525
47MP0001661_extended_life_span1.22926669
48MP0005409_darkened_coat_color1.22092731
49MP0000538_abnormal_urinary_bladder1.21517583
50MP0004272_abnormal_basement_membrane1.21458483
51MP0010368_abnormal_lymphatic_system1.19118106
52MP0004145_abnormal_muscle_electrophysio1.18415619
53MP0001958_emphysema1.17311392
54MP0009250_abnormal_appendicular_skeleto1.11255573
55MP0003942_abnormal_urinary_system1.10111555
56* MP0000266_abnormal_heart_morphology1.08532215
57MP0002234_abnormal_pharynx_morphology1.06263072
58MP0005167_abnormal_blood-brain_barrier1.03348831
59MP0001664_abnormal_digestion1.02427303
60MP0005670_abnormal_white_adipose1.01844031
61MP0003566_abnormal_cell_adhesion1.01442248
62MP0005197_abnormal_uvea_morphology0.97596390
63MP0003941_abnormal_skin_development0.96996633
64MP0000003_abnormal_adipose_tissue0.95723147
65MP0000428_abnormal_craniofacial_morphol0.95258730
66MP0003283_abnormal_digestive_organ0.93008746
67MP0000534_abnormal_ureter_morphology0.92747622
68MP0005666_abnormal_adipose_tissue0.92551489
69* MP0002751_abnormal_autonomic_nervous0.92337995
70MP0005187_abnormal_penis_morphology0.92290636
71MP0000230_abnormal_systemic_arterial0.92007677
72MP0004043_abnormal_pH_regulation0.91795262
73MP0005375_adipose_tissue_phenotype0.89274019
74MP0010030_abnormal_orbit_morphology0.88913892
75MP0000462_abnormal_digestive_system0.87050402
76MP0002697_abnormal_eye_size0.85866756
77MP0000537_abnormal_urethra_morphology0.84551496
78MP0000767_abnormal_smooth_muscle0.81440751
79MP0005508_abnormal_skeleton_morphology0.81202083
80MP0005085_abnormal_gallbladder_physiolo0.80485167
81MP0006036_abnormal_mitochondrial_physio0.80446802
82MP0003045_fibrosis0.80238479
83MP0009840_abnormal_foam_cell0.79731938
84MP0003950_abnormal_plasma_membrane0.79200350
85MP0004264_abnormal_extraembryonic_tissu0.78617756
86MP0002332_abnormal_exercise_endurance0.78118064
87MP0003385_abnormal_body_wall0.77721954
88MP0008961_abnormal_basal_metabolism0.76649440
89MP0001270_distended_abdomen0.76063381
90MP0000516_abnormal_urinary_system0.73705770
91MP0005367_renal/urinary_system_phenotyp0.73705770
92* MP0003935_abnormal_craniofacial_develop0.73433006
93* MP0002128_abnormal_blood_circulation0.73415267
94MP0001730_embryonic_growth_arrest0.72379995
95MP0010386_abnormal_urinary_bladder0.71395646
96MP0001756_abnormal_urination0.70269314
97MP0002932_abnormal_joint_morphology0.70136598
98MP0001299_abnormal_eye_distance/0.69947781
99* MP0003937_abnormal_limbs/digits/tail_de0.69123048
100MP0002184_abnormal_innervation0.68533456
101MP0002295_abnormal_pulmonary_circulatio0.67237113
102MP0002249_abnormal_larynx_morphology0.66477312
103* MP0003984_embryonic_growth_retardation0.65176181
104MP0001879_abnormal_lymphatic_vessel0.65081157
105* MP0002088_abnormal_embryonic_growth/wei0.63605381
106MP0003121_genomic_imprinting0.63142867
107MP0004883_abnormal_blood_vessel0.62958773
108MP0009053_abnormal_anal_canal0.62292990
109MP0002166_altered_tumor_susceptibility0.61612599
110MP0005645_abnormal_hypothalamus_physiol0.61257095
111* MP0002109_abnormal_limb_morphology0.59498724
112MP0002102_abnormal_ear_morphology0.59256071
113MP0000343_altered_response_to0.56275563
114MP0001348_abnormal_lacrimal_gland0.56039001
115MP0005503_abnormal_tendon_morphology0.55696823
116* MP0002925_abnormal_cardiovascular_devel0.55407963
117MP0003787_abnormal_imprinting0.55214426
118MP0005193_abnormal_anterior_eye0.54938296
119MP0002114_abnormal_axial_skeleton0.54009648
120MP0005165_increased_susceptibility_to0.53494902
121MP0001340_abnormal_eyelid_morphology0.52468161
122* MP0001614_abnormal_blood_vessel0.51812359
123MP0000639_abnormal_adrenal_gland0.51325896
124MP0005266_abnormal_metabolism0.51323759
125* MP0005319_abnormal_enzyme/_coenzyme0.50947304
126MP0003959_abnormal_lean_body0.50703382
127MP0003948_abnormal_gas_homeostasis0.50027207
128MP0002108_abnormal_muscle_morphology0.49849454
129MP0003868_abnormal_feces_composition0.48677756
130MP0009384_cardiac_valve_regurgitation0.48644423
131MP0006072_abnormal_retinal_apoptosis0.46940724
132MP0005451_abnormal_body_composition0.45829456
133MP0000733_abnormal_muscle_development0.43521949
134MP0002078_abnormal_glucose_homeostasis0.43375264
135MP0003115_abnormal_respiratory_system0.42340756
136* MP0000249_abnormal_blood_vessel0.41835907

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.25763883
2Ventricular tachycardia (HP:0004756)5.85480090
3Atrial fibrillation (HP:0005110)5.28160470
4Subaortic stenosis (HP:0001682)5.08578014
5Abnormality of the left ventricular outflow tract (HP:0011103)5.08578014
6Primary atrial arrhythmia (HP:0001692)5.00188128
7Supraventricular tachycardia (HP:0004755)4.84982377
8Abnormality of the phalanges of the 2nd finger (HP:0009541)4.84785370
9Supraventricular arrhythmia (HP:0005115)4.77955243
10Lipoatrophy (HP:0100578)4.70983939
11Calf muscle hypertrophy (HP:0008981)4.59830975
12Right ventricular cardiomyopathy (HP:0011663)4.54581269
13Exercise-induced muscle cramps (HP:0003710)4.50033961
14Pheochromocytoma (HP:0002666)4.40759615
15Syncope (HP:0001279)4.37834748
16Muscle fiber splitting (HP:0003555)4.31085726
17Abnormality of the calf musculature (HP:0001430)4.30356282
18Asymmetry of the thorax (HP:0001555)4.23835932
19Hyporeflexia of lower limbs (HP:0002600)4.22472149
20Palpitations (HP:0001962)4.16101242
21Muscle hypertrophy of the lower extremities (HP:0008968)4.06393547
22Prolonged QT interval (HP:0001657)4.00871159
23Exercise-induced myalgia (HP:0003738)3.97554504
24Neuroendocrine neoplasm (HP:0100634)3.83974068
25Asymmetric septal hypertrophy (HP:0001670)3.71208012
26Myoglobinuria (HP:0002913)3.68899990
27Dilated cardiomyopathy (HP:0001644)3.64428872
28Annular pancreas (HP:0001734)3.58726801
29Ventricular arrhythmia (HP:0004308)3.51015690
30EMG: myopathic abnormalities (HP:0003458)3.45814329
31Bundle branch block (HP:0011710)3.42809724
32Abnormality of the 2nd finger (HP:0004100)3.34636313
33Ventricular fibrillation (HP:0001663)3.30642404
34Hypercortisolism (HP:0001578)3.21348716
35Atrioventricular block (HP:0001678)3.19104453
36Enlarged penis (HP:0000040)3.17768921
37Partial duplication of the phalanx of hand (HP:0009999)3.11579452
38Orthostatic hypotension (HP:0001278)3.08477838
39Increased connective tissue (HP:0009025)3.05250776
40Heart block (HP:0012722)2.99406115
41Myotonia (HP:0002486)2.97390149
42Abnormality of the phalanges of the hallux (HP:0010057)2.97170366
43Bowel diverticulosis (HP:0005222)2.87350350
44Abnormal EKG (HP:0003115)2.86331816
45Abnormal atrioventricular conduction (HP:0005150)2.84014164
46Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.82395585
47Rhabdomyolysis (HP:0003201)2.75118237
48Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.74805383
49Left ventricular hypertrophy (HP:0001712)2.73805621
50Aortic aneurysm (HP:0004942)2.73400709
51Abnormal autonomic nervous system physiology (HP:0012332)2.68041175
52Hypoventilation (HP:0002791)2.63644498
53Turricephaly (HP:0000262)2.62611002
54Cerebral hemorrhage (HP:0001342)2.61367042
55Abnormal connection of the cardiac segments (HP:0011545)2.58264964
56Abnormal ventriculo-arterial connection (HP:0011563)2.58264964
57Transposition of the great arteries (HP:0001669)2.58264964
58Neoplasm of the peripheral nervous system (HP:0100007)2.53842523
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.52825359
60Protrusio acetabuli (HP:0003179)2.52420864
61Premature rupture of membranes (HP:0001788)2.52071614
62Coronal craniosynostosis (HP:0004440)2.47654688
63Patent foramen ovale (HP:0001655)2.44841557
64Bicornuate uterus (HP:0000813)2.44746931
65Depressed nasal tip (HP:0000437)2.41739511
66Congenital malformation of the right heart (HP:0011723)2.33652591
67Double outlet right ventricle (HP:0001719)2.33652591
68Potter facies (HP:0002009)2.33306284
69Facial shape deformation (HP:0011334)2.33306284
70Ketoacidosis (HP:0001993)2.33278336
71Difficulty climbing stairs (HP:0003551)2.32679707
72Pulmonary artery stenosis (HP:0004415)2.30921990
73Abnormality of the parathyroid morphology (HP:0011766)2.30359313
74Esophageal atresia (HP:0002032)2.29874672
75Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.24227678
76Type 1 muscle fiber predominance (HP:0003803)2.23854473
77Shallow orbits (HP:0000586)2.23622147
78Abnormality of the phalanges of the 5th finger (HP:0004213)2.21876642
79Limb-girdle muscle atrophy (HP:0003797)2.21508925
80Hypoglycemic coma (HP:0001325)2.21071541
81Hypothermia (HP:0002045)2.19579890
82Truncus arteriosus (HP:0001660)2.18698306
83Difficulty running (HP:0009046)2.18215225
84Broad metatarsal (HP:0001783)2.17930006
85Bradycardia (HP:0001662)2.17614009
86Abnormality of calcium-phosphate metabolism (HP:0100530)2.17117869
87Cerebral edema (HP:0002181)2.16780559
88Aortic dissection (HP:0002647)2.13860418
89Bladder diverticulum (HP:0000015)2.12653728
90Conjunctival hamartoma (HP:0100780)2.11304818
91Hyperthyroidism (HP:0000836)2.11173716
92Periauricular skin pits (HP:0100277)2.10558845
93Preauricular pit (HP:0004467)2.10558845
94Intestinal atresia (HP:0011100)2.10338051
95Palmoplantar keratoderma (HP:0000982)2.09960704
96Hepatic necrosis (HP:0002605)2.09907114
97Hypoplastic heart (HP:0001961)2.08117772
98Ragged-red muscle fibers (HP:0003200)2.05555025
99Goiter (HP:0000853)2.04839596
100Centrally nucleated skeletal muscle fibers (HP:0003687)2.04363666
101Sudden cardiac death (HP:0001645)2.04088960
102Amblyopia (HP:0000646)2.00087783
103Hypoplastic left heart (HP:0004383)1.99650716
104Lymphangioma (HP:0100764)1.98045180
105Long toe (HP:0010511)1.97834992
106Acute necrotizing encephalopathy (HP:0006965)1.95662781
107Congestive heart failure (HP:0001635)1.95473001
108Abnormality of the foot musculature (HP:0001436)1.94002060
109Abnormal mitochondria in muscle tissue (HP:0008316)1.93097739
110Soft skin (HP:0000977)1.91570927
111Abnormal umbilical cord blood vessels (HP:0011403)1.90250887
112Single umbilical artery (HP:0001195)1.90250887
113Abnormality of the fetal cardiovascular system (HP:0010948)1.90250887
114Neoplasm of the adrenal gland (HP:0100631)1.88834646
115Scapular winging (HP:0003691)1.88751513
116Aneurysm (HP:0002617)1.88452270
117Hip contracture (HP:0003273)1.88265228
118Exotropia (HP:0000577)1.88224450
119Testicular neoplasm (HP:0010788)1.87023517
120Failure to thrive in infancy (HP:0001531)1.86765106
121Wide anterior fontanel (HP:0000260)1.86582679
122Neonatal hypoglycemia (HP:0001998)1.85670568
123Neuroblastic tumors (HP:0004376)1.84949229
124Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.84949229
125Neuroblastoma (HP:0003006)1.84949229
126Primitive neuroectodermal tumor (HP:0030065)1.84949229
127Ketosis (HP:0001946)1.84326604
128Agitation (HP:0000713)1.82767897
129Increased variability in muscle fiber diameter (HP:0003557)1.82757860
130Intestinal polyposis (HP:0200008)1.79835783
131Muscle stiffness (HP:0003552)1.79656957
132EMG: neuropathic changes (HP:0003445)1.79234984
133Skin nodule (HP:0200036)1.79123064
134Abnormality of the tricuspid valve (HP:0001702)1.78760515
135Distal lower limb muscle weakness (HP:0009053)1.77076888
136Hepatocellular necrosis (HP:0001404)1.75890465
137Foot dorsiflexor weakness (HP:0009027)1.75383600
138Disproportionate tall stature (HP:0001519)1.75337862
139Striae distensae (HP:0001065)1.74903508
140Abnormality of the aortic arch (HP:0012303)1.72580640
141Abnormality of fatty-acid metabolism (HP:0004359)1.71981355
142Cerebral aneurysm (HP:0004944)1.71639408
143Cholelithiasis (HP:0001081)1.71600047
144Acute encephalopathy (HP:0006846)1.70084974
145Hyperammonemia (HP:0001987)1.69303092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.61698652
2TTN4.47721949
3PKN23.97576757
4MYLK3.81531789
5FLT33.34572507
6LMTK23.29486322
7TRIB33.23236942
8NTRK12.76848232
9PHKG22.61453032
10PHKG12.61453032
11AKT32.48860618
12PDGFRA2.47014982
13NEK12.44062446
14DMPK2.37446142
15OBSCN2.32013074
16SIK11.90717123
17STK241.90415153
18PTK21.89055297
19PDK41.85257875
20PDK31.85257875
21BCKDK1.84333627
22GRK71.75099691
23ILK1.61757921
24EEF2K1.59391180
25CAMK41.49842987
26TIE11.48024492
27PIK3CA1.47289292
28RET1.44710227
29RPS6KC11.42531343
30RPS6KL11.42531343
31MET1.40019179
32PAK31.37069651
33RIPK11.34354447
34CDC42BPA1.30862505
35DAPK31.21398931
36RPS6KA61.21366758
37ROCK11.19952705
38CAMK11.17852922
39EPHB21.15381760
40PRKD11.13416265
41MUSK1.13379483
42STK38L1.11047437
43MAP3K61.06682430
44PDGFRB1.05918208
45INSRR1.05342757
46SCYL21.04430786
47WNK41.01871100
48LATS21.00572937
49DYRK1B0.90962296
50PDK20.89022678
51TLK10.88202579
52CAMK2D0.88155004
53TRPM70.87895683
54RPS6KA20.86893976
55PTK60.85955111
56NME20.84786614
57MAP3K100.82969801
58FGFR20.81724388
59ERN10.81721313
60ICK0.80807414
61ROCK20.71728218
62MTOR0.71233057
63MAP2K30.71089638
64LIMK10.71066008
65ALK0.71050918
66ERBB20.68706202
67NTRK20.68489135
68PTK2B0.68424206
69MAPK120.66258400
70LRRK20.64173287
71MAP3K70.64153061
72TGFBR10.63132981
73STK40.61393910
74LATS10.60932227
75CDK40.59469952
76WNK10.59320446
77ADRBK10.58127162
78MAP2K10.57771074
79PINK10.55305152
80MAPKAPK30.53709221
81ZAP700.52864355
82SMG10.49342770
83FGFR10.49294528
84KDR0.48967379
85CAMK2A0.48708171
86PRKAA20.47399286
87PRKD30.47118699
88PRKAA10.46281366
89CAMK2G0.45790680
90PKN10.45562340
91PRKACG0.45462611
92DDR20.44445194
93PRKCE0.43968156
94NEK90.42807759
95PRKG20.42743070
96MAPK70.41895554
97MATK0.40516939
98PAK20.39812918
99IGF1R0.39622412
100PRKACA0.39040793
101PRPF4B0.38396600
102AKT20.38370905
103MAP3K50.37983192
104AKT10.37597595
105PRKACB0.36534334
106GRK50.36410292
107NEK20.35988622
108UHMK10.35626743
109PRKD20.35396443
110TGFBR20.33977367
111FER0.33506779
112MAP3K30.33292211
113NLK0.32765127
114TYRO30.31444217
115CLK10.30979070
116MELK0.29996315
117MAP3K40.29807026
118RPS6KA10.29355628
119SRPK10.28671812
120FGFR40.28227909
121CDK60.25908119
122MAPK10.25676113
123MARK20.21798330
124SRC0.21524733
125MAPK80.19837305
126PRKCH0.19506965
127MAPK40.18241022
128MAPK110.17867879

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.58129499
2Cardiac muscle contraction_Homo sapiens_hsa042603.50999258
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.49961461
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.46048930
5Dilated cardiomyopathy_Homo sapiens_hsa054143.29005647
6Arginine biosynthesis_Homo sapiens_hsa002203.00177040
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.89267302
8Parkinsons disease_Homo sapiens_hsa050122.68132427
9Oxidative phosphorylation_Homo sapiens_hsa001902.47242995
10Propanoate metabolism_Homo sapiens_hsa006402.43350952
11Fatty acid degradation_Homo sapiens_hsa000712.40071910
12Carbon metabolism_Homo sapiens_hsa012002.21289149
13Alzheimers disease_Homo sapiens_hsa050101.97231545
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.89505269
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89425786
16Fatty acid metabolism_Homo sapiens_hsa012121.85492794
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79648439
18Phenylalanine metabolism_Homo sapiens_hsa003601.78896062
19Arginine and proline metabolism_Homo sapiens_hsa003301.71523040
20Pyruvate metabolism_Homo sapiens_hsa006201.62755400
21Tryptophan metabolism_Homo sapiens_hsa003801.62634598
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61256018
23Biosynthesis of amino acids_Homo sapiens_hsa012301.59139754
24Tyrosine metabolism_Homo sapiens_hsa003501.56544590
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56329801
26Huntingtons disease_Homo sapiens_hsa050161.53948707
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.48359133
28Butanoate metabolism_Homo sapiens_hsa006501.41131014
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.36400441
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28252859
31Protein digestion and absorption_Homo sapiens_hsa049741.24674471
32Non-small cell lung cancer_Homo sapiens_hsa052231.19271808
33Small cell lung cancer_Homo sapiens_hsa052221.18109770
34Viral myocarditis_Homo sapiens_hsa054161.16877657
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10724214
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09495863
37PPAR signaling pathway_Homo sapiens_hsa033201.07751665
38Glucagon signaling pathway_Homo sapiens_hsa049221.05964270
39TGF-beta signaling pathway_Homo sapiens_hsa043501.04088557
40Bile secretion_Homo sapiens_hsa049761.03776230
41Alcoholism_Homo sapiens_hsa050341.02577122
42Lysine degradation_Homo sapiens_hsa003100.98407400
43Glioma_Homo sapiens_hsa052140.97561080
44Galactose metabolism_Homo sapiens_hsa000520.97370461
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96694373
46Insulin resistance_Homo sapiens_hsa049310.93936585
47Fatty acid elongation_Homo sapiens_hsa000620.90838864
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90152183
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89381559
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89325202
51Melanoma_Homo sapiens_hsa052180.89218815
52Hedgehog signaling pathway_Homo sapiens_hsa043400.88159626
53Starch and sucrose metabolism_Homo sapiens_hsa005000.86771859
54Insulin signaling pathway_Homo sapiens_hsa049100.85838574
55Ovarian steroidogenesis_Homo sapiens_hsa049130.82589317
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80340783
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80186454
58Fructose and mannose metabolism_Homo sapiens_hsa000510.78768778
59AMPK signaling pathway_Homo sapiens_hsa041520.78668821
60Axon guidance_Homo sapiens_hsa043600.77722218
61Endometrial cancer_Homo sapiens_hsa052130.77248993
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.76482224
63MicroRNAs in cancer_Homo sapiens_hsa052060.76422420
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.76381559
65Prion diseases_Homo sapiens_hsa050200.76292264
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75678925
67Chronic myeloid leukemia_Homo sapiens_hsa052200.73209306
68Focal adhesion_Homo sapiens_hsa045100.73153488
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73015917
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72695051
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72067360
72Thyroid cancer_Homo sapiens_hsa052160.71332843
73Pathways in cancer_Homo sapiens_hsa052000.69731485
74HIF-1 signaling pathway_Homo sapiens_hsa040660.69267821
75Type II diabetes mellitus_Homo sapiens_hsa049300.69034474
76Systemic lupus erythematosus_Homo sapiens_hsa053220.68777637
77Renin secretion_Homo sapiens_hsa049240.68502108
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68501643
79Hippo signaling pathway_Homo sapiens_hsa043900.66366625
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65730995
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62542368
82Histidine metabolism_Homo sapiens_hsa003400.57227617
83Amphetamine addiction_Homo sapiens_hsa050310.56439352
84beta-Alanine metabolism_Homo sapiens_hsa004100.55196733
85Wnt signaling pathway_Homo sapiens_hsa043100.54790641
86Prostate cancer_Homo sapiens_hsa052150.53611317
87Circadian entrainment_Homo sapiens_hsa047130.52509959
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51349483
89Choline metabolism in cancer_Homo sapiens_hsa052310.50454652
90Cocaine addiction_Homo sapiens_hsa050300.50429108
91Amoebiasis_Homo sapiens_hsa051460.49590169
92Pentose phosphate pathway_Homo sapiens_hsa000300.49270478
93Insulin secretion_Homo sapiens_hsa049110.49240026
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.49178309
95Fat digestion and absorption_Homo sapiens_hsa049750.48517053
96Tight junction_Homo sapiens_hsa045300.46036966
97Rap1 signaling pathway_Homo sapiens_hsa040150.45682189
98Gap junction_Homo sapiens_hsa045400.45288773
99Estrogen signaling pathway_Homo sapiens_hsa049150.45080637
100Circadian rhythm_Homo sapiens_hsa047100.44772941
101Calcium signaling pathway_Homo sapiens_hsa040200.43449034
102Colorectal cancer_Homo sapiens_hsa052100.43141116
103Adherens junction_Homo sapiens_hsa045200.43135664
104Melanogenesis_Homo sapiens_hsa049160.42743159
105Cholinergic synapse_Homo sapiens_hsa047250.42474949
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42078510
107ECM-receptor interaction_Homo sapiens_hsa045120.41302310
108mRNA surveillance pathway_Homo sapiens_hsa030150.41095502
109mTOR signaling pathway_Homo sapiens_hsa041500.40609341
110VEGF signaling pathway_Homo sapiens_hsa043700.40027963
111Pancreatic cancer_Homo sapiens_hsa052120.38551889
112Dopaminergic synapse_Homo sapiens_hsa047280.38414285
113Oxytocin signaling pathway_Homo sapiens_hsa049210.37927881
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.36560950
115Salivary secretion_Homo sapiens_hsa049700.35261259
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34852226
117GnRH signaling pathway_Homo sapiens_hsa049120.34771806
118Notch signaling pathway_Homo sapiens_hsa043300.34121315
119Morphine addiction_Homo sapiens_hsa050320.33422910
120Proteoglycans in cancer_Homo sapiens_hsa052050.32773029
121cAMP signaling pathway_Homo sapiens_hsa040240.32489459
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31159395
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30588735
124Peroxisome_Homo sapiens_hsa041460.30541948
125Gastric acid secretion_Homo sapiens_hsa049710.30514243
126Pancreatic secretion_Homo sapiens_hsa049720.30186405
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.28748849
128Platelet activation_Homo sapiens_hsa046110.28073011
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27081724
130Long-term depression_Homo sapiens_hsa047300.26124458
131Thyroid hormone synthesis_Homo sapiens_hsa049180.24832743
132Basal cell carcinoma_Homo sapiens_hsa052170.24040259
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.23830360
134Metabolic pathways_Homo sapiens_hsa011000.21608578
135Glycerolipid metabolism_Homo sapiens_hsa005610.20507368
136Renal cell carcinoma_Homo sapiens_hsa052110.20020716
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.18790043

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