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Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.64181879
2L-phenylalanine catabolic process (GO:0006559)7.64181879
3L-phenylalanine metabolic process (GO:0006558)7.26391053
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.26391053
5aromatic amino acid family catabolic process (GO:0009074)6.91501849
6indole-containing compound catabolic process (GO:0042436)6.30361745
7indolalkylamine catabolic process (GO:0046218)6.30361745
8tryptophan catabolic process (GO:0006569)6.30361745
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.17742246
10kynurenine metabolic process (GO:0070189)6.10072980
11bile acid biosynthetic process (GO:0006699)5.97143529
12tryptophan metabolic process (GO:0006568)5.91887638
13urea metabolic process (GO:0019627)5.83427054
14urea cycle (GO:0000050)5.83427054
15glyoxylate metabolic process (GO:0046487)5.65451890
16high-density lipoprotein particle remodeling (GO:0034375)5.51221193
17negative regulation of fibrinolysis (GO:0051918)5.48262398
18complement activation, alternative pathway (GO:0006957)5.45648303
19protein carboxylation (GO:0018214)5.40887099
20peptidyl-glutamic acid carboxylation (GO:0017187)5.40887099
21sulfur amino acid catabolic process (GO:0000098)5.38064371
22nitrogen cycle metabolic process (GO:0071941)5.36413035
23regulation of fibrinolysis (GO:0051917)5.35873175
24regulation of protein activation cascade (GO:2000257)5.35433080
25cysteine metabolic process (GO:0006534)5.34903657
26alpha-linolenic acid metabolic process (GO:0036109)5.34632664
27detection of other organism (GO:0098543)5.27101300
28serine family amino acid catabolic process (GO:0009071)5.14559750
29bile acid metabolic process (GO:0008206)5.08476396
30detection of bacterium (GO:0016045)5.06240541
31regulation of complement activation (GO:0030449)5.01898488
32aromatic amino acid family metabolic process (GO:0009072)5.00056393
33homocysteine metabolic process (GO:0050667)4.93384399
34detection of molecule of bacterial origin (GO:0032490)4.93384381
35detection of external biotic stimulus (GO:0098581)4.87679265
36tyrosine metabolic process (GO:0006570)4.83551309
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.79006159
38killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.78046272
39disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.78046272
40regulation of cholesterol esterification (GO:0010872)4.78017580
41reverse cholesterol transport (GO:0043691)4.77441288
42regulation of triglyceride catabolic process (GO:0010896)4.75895867
43phospholipid efflux (GO:0033700)4.71590484
44protein-lipid complex remodeling (GO:0034368)4.69802712
45macromolecular complex remodeling (GO:0034367)4.69802712
46plasma lipoprotein particle remodeling (GO:0034369)4.69802712
47* alpha-amino acid catabolic process (GO:1901606)4.62634576
48amino-acid betaine metabolic process (GO:0006577)4.60667269
49acylglycerol homeostasis (GO:0055090)4.60131269
50triglyceride homeostasis (GO:0070328)4.60131269
51indolalkylamine metabolic process (GO:0006586)4.47567306
52negative regulation of cholesterol transport (GO:0032375)4.46590098
53negative regulation of sterol transport (GO:0032372)4.46590098
54lysine metabolic process (GO:0006553)4.46408306
55lysine catabolic process (GO:0006554)4.46408306
56epoxygenase P450 pathway (GO:0019373)4.43719109
57exogenous drug catabolic process (GO:0042738)4.42425065
58coenzyme catabolic process (GO:0009109)4.42351152
59amine catabolic process (GO:0009310)4.41969773
60cellular biogenic amine catabolic process (GO:0042402)4.41969773
61bile acid and bile salt transport (GO:0015721)4.41891209
62omega-hydroxylase P450 pathway (GO:0097267)4.40683528
63glycine metabolic process (GO:0006544)4.34684515
64plasma lipoprotein particle clearance (GO:0034381)4.33846666
65leukocyte migration involved in inflammatory response (GO:0002523)4.28358348
66positive regulation by organism of defense response of other organism involved in symbiotic interact4.27153242
67modulation by symbiont of host immune response (GO:0052553)4.27153242
68positive regulation by symbiont of host defense response (GO:0052509)4.27153242
69modulation by symbiont of host defense response (GO:0052031)4.27153242
70modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.27153242
71modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.27153242
72cellular ketone body metabolic process (GO:0046950)4.27035231
73cellular glucuronidation (GO:0052695)4.26332721
74detection of biotic stimulus (GO:0009595)4.25609019
75* cellular amino acid catabolic process (GO:0009063)4.24077961
76negative regulation of protein activation cascade (GO:2000258)4.20573281
77cholesterol efflux (GO:0033344)4.19660448
78regulation of humoral immune response (GO:0002920)4.19277131
79benzene-containing compound metabolic process (GO:0042537)4.13319898
80serine family amino acid metabolic process (GO:0009069)4.12906257
81fibrinolysis (GO:0042730)4.12293235
82arginine metabolic process (GO:0006525)4.08928619
83cellular modified amino acid catabolic process (GO:0042219)4.08120982
84ethanol oxidation (GO:0006069)4.07929702
85negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.06098350
86negative regulation of cell killing (GO:0031342)4.06098350
87* imidazole-containing compound metabolic process (GO:0052803)4.05642538
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.03841608
89low-density lipoprotein particle remodeling (GO:0034374)4.01061182
90aldehyde catabolic process (GO:0046185)3.98386608
91* glutamate metabolic process (GO:0006536)3.98020682
92dicarboxylic acid biosynthetic process (GO:0043650)3.95620028
93serine family amino acid biosynthetic process (GO:0009070)3.94804022
94plasma lipoprotein particle assembly (GO:0034377)3.92279955
95blood coagulation, intrinsic pathway (GO:0007597)3.84160601
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.82754832
97complement activation (GO:0006956)3.81740782
98drug catabolic process (GO:0042737)3.81373956
99negative regulation of lipase activity (GO:0060192)3.81052366
100complement activation, classical pathway (GO:0006958)3.80878991
101regulation of bile acid biosynthetic process (GO:0070857)3.80790138
102cofactor catabolic process (GO:0051187)3.80660775
103glucuronate metabolic process (GO:0019585)3.80326192
104uronic acid metabolic process (GO:0006063)3.80326192
105protein activation cascade (GO:0072376)3.78478746
106very-low-density lipoprotein particle assembly (GO:0034379)3.73639800
107macrophage activation involved in immune response (GO:0002281)3.73316430
108cholesterol homeostasis (GO:0042632)3.71188655
109positive regulation of gamma-delta T cell activation (GO:0046645)3.71052509
110acute-phase response (GO:0006953)3.69949734
111* organic acid catabolic process (GO:0016054)3.69375006
112* carboxylic acid catabolic process (GO:0046395)3.69375006
113ketone body metabolic process (GO:1902224)3.69121346
114neutrophil activation involved in immune response (GO:0002283)3.68075830
115positive regulation of triglyceride lipase activity (GO:0061365)3.65911172
116positive regulation of lipoprotein lipase activity (GO:0051006)3.65911172
117acetyl-CoA metabolic process (GO:0006084)3.65170781
118sterol homeostasis (GO:0055092)3.64442947
119regulation of cholesterol homeostasis (GO:2000188)3.64251948
120phospholipid homeostasis (GO:0055091)3.64249798
121cytolysis (GO:0019835)3.64079740
122positive regulation of lipid catabolic process (GO:0050996)3.62593453
123NAD biosynthetic process (GO:0009435)3.62472250
124opsonization (GO:0008228)3.56929735
125plasma lipoprotein particle organization (GO:0071827)3.56794920
126pyridine nucleotide biosynthetic process (GO:0019363)3.56220783
127nicotinamide nucleotide biosynthetic process (GO:0019359)3.56220783
128negative regulation of lymphocyte mediated immunity (GO:0002707)3.55763954
129cellular extravasation (GO:0045123)3.55710936
130keratinization (GO:0031424)3.51552535
131negative regulation of complement activation (GO:0045916)3.48476488
132positive regulation of blood coagulation (GO:0030194)3.43307379
133positive regulation of hemostasis (GO:1900048)3.43307379
134antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.42797034
135establishment of skin barrier (GO:0061436)3.41950902
136response to peptidoglycan (GO:0032494)3.38974536
137positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.37015941
138negative regulation of B cell mediated immunity (GO:0002713)3.35011025
139negative regulation of immunoglobulin mediated immune response (GO:0002890)3.35011025
140antigen processing and presentation of endogenous antigen (GO:0019883)3.34822635
141neutrophil mediated immunity (GO:0002446)3.26928258
142positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.26630678
143negative regulation of humoral immune response (GO:0002921)3.23831064
144positive regulation of coagulation (GO:0050820)3.18923400
145negative regulation of hemostasis (GO:1900047)3.11925634
146negative regulation of blood coagulation (GO:0030195)3.11925634
147microglial cell activation (GO:0001774)3.07275894
148regulation of gamma-delta T cell activation (GO:0046643)3.04961258
149regulation of B cell receptor signaling pathway (GO:0050855)3.04213664
150antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.03153303
151regulation of interferon-beta biosynthetic process (GO:0045357)3.01893956
152neutrophil activation (GO:0042119)3.01602173
153regulation of acute inflammatory response (GO:0002673)2.97171565
154response to interleukin-15 (GO:0070672)2.92773490
155macrophage activation (GO:0042116)2.92230255
156positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90838550
157positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.89549800
158negative regulation of leukocyte mediated immunity (GO:0002704)2.88997990
159acute inflammatory response (GO:0002526)2.88820945
160regulation of apoptotic cell clearance (GO:2000425)2.88781016
161regulation of water loss via skin (GO:0033561)2.86910381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.15082067
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.98226648
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.98177838
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.36219982
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.26985512
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.83094824
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.56757909
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97918629
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.77910400
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.25937998
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.14776868
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.96759012
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86310214
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71043076
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.64195530
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.63457958
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44985051
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43117713
19RUNX_20019798_ChIP-Seq_JUKART_Human2.26458210
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23977002
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20172852
22* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5239896
23VDR_24763502_ChIP-Seq_THP-1_Human1.99745622
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99237673
25SPI1_23547873_ChIP-Seq_NB4_Human1.84705396
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81402887
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81302240
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80457058
29SCL_19346495_ChIP-Seq_HPC-7_Human1.78969185
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76001168
31VDR_24787735_ChIP-Seq_THP-1_Human1.75664570
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71242809
33SPI1_23127762_ChIP-Seq_K562_Human1.70241256
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69346185
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68417124
36VDR_21846776_ChIP-Seq_THP-1_Human1.66825268
37HTT_18923047_ChIP-ChIP_STHdh_Human1.66597285
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.58531295
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56706503
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.53956221
41MYB_26560356_Chip-Seq_TH1_Human1.52198572
42MYB_26560356_Chip-Seq_TH2_Human1.50029435
43MAF_26560356_Chip-Seq_TH1_Human1.43736205
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39714743
45CLOCK_20551151_ChIP-Seq_293T_Human1.39056434
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.39037643
47TCF7_22412390_ChIP-Seq_EML_Mouse1.37196123
48* HNF4A_19822575_ChIP-Seq_HepG2_Human1.31376897
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.30640630
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28580851
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28547008
52GATA1_22025678_ChIP-Seq_K562_Human1.27645557
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25914567
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25348708
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24065262
56GATA3_27048872_Chip-Seq_THYMUS_Human1.22722395
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21752631
58UTX_26944678_Chip-Seq_JUKART_Human1.21387794
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18588573
60RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17609729
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17129511
62* PU_27001747_Chip-Seq_BMDM_Mouse1.14715436
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14654544
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14620022
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12891771
66* GATA3_26560356_Chip-Seq_TH2_Human1.12036262
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08424720
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.08113078
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07285084
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06140313
71GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05381746
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01166523
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99031713
74KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97748503
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95627870
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94832504
77ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94682258
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90883726
79EGR1_19374776_ChIP-ChIP_THP-1_Human0.90698136
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89686004
81* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89339971
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89214425
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88890977
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88644971
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88641878
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86988072
87IRF8_22096565_ChIP-ChIP_GC-B_Human0.86356768
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85736479
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85735740
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85647109
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85478573
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85264156
93* GATA4_25053715_ChIP-Seq_YYC3_Human0.84060516
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83983365
95RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83815158
96KDM2B_26808549_Chip-Seq_DND41_Human0.83412055
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83278887
98MAF_26560356_Chip-Seq_TH2_Human0.82228990
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82050857
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.81809194
101* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80451552
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78560113
103SPI1_20517297_ChIP-Seq_HL60_Human0.76533810
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73326778
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73326778
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72946185
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72220501
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71653856
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.68088535
110CEBPB_22108803_ChIP-Seq_LS180_Human0.67698205
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66959902
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66932893
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.66014916
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65801865
115TP63_17297297_ChIP-ChIP_HaCaT_Human0.65217942
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65128184
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63230695
118TAF15_26573619_Chip-Seq_HEK293_Human0.61495619
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61207657
120EGR1_19032775_ChIP-ChIP_M12_Human0.60395356
121ZNF263_19887448_ChIP-Seq_K562_Human0.59492452
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.59094961
123RARB_24833708_ChIP-Seq_LIVER_Mouse0.58746488
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.57438202
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57302175
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.57028691
127STAT1_17558387_ChIP-Seq_HELA_Human0.54853197
128AR_20517297_ChIP-Seq_VCAP_Human0.54688429
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.54314505
130BCAT_22108803_ChIP-Seq_LS180_Human0.54039723
131MYC_19915707_ChIP-ChIP_AK7_Human0.53236807
132LXR_22292898_ChIP-Seq_THP-1_Human0.51952716
133CBP_21632823_ChIP-Seq_H3396_Human0.51756399
134ESET_19884257_ChIP-Seq_ESCs_Mouse0.50449100
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49934680
136P53_21459846_ChIP-Seq_SAOS-2_Human0.49849985
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.49534362
138* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.48189657
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.48132689
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.46831718
141* TAF2_19829295_ChIP-Seq_ESCs_Human0.45282325
142P63_26484246_Chip-Seq_KERATINOCYTES_Human0.45190651
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.45088815
144PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44330970
145* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.43530382
146SOX2_20726797_ChIP-Seq_SW620_Human0.43417750
147* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43321820
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.42796677
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.42049489
150* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42029637
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41799295
152E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.41547292
153GATA2_19941826_ChIP-Seq_K562_Human0.41002624
154CDX2_22108803_ChIP-Seq_LS180_Human0.40894399
155* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40403715
156CRX_20693478_ChIP-Seq_RETINA_Mouse0.39498241
157GATA6_25053715_ChIP-Seq_YYC3_Human0.39319218
158FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39132831
159MYC_27129775_Chip-Seq_CORNEA_Mouse0.38684722
160OCT4_21477851_ChIP-Seq_ESCs_Mouse0.37942052
161GATA1_19941826_ChIP-Seq_K562_Human0.37856552
162TP63_23658742_ChIP-Seq_EP156T_Human0.37714550
163GATA3_24758297_ChIP-Seq_MCF-7_Human0.37438376
164STAT3_1855785_ChIP-Seq_MESCs_Mouse0.36799010
165GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.36798710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.05778729
2MP0005360_urolithiasis7.49370710
3MP0005085_abnormal_gallbladder_physiolo6.36736168
4MP0005365_abnormal_bile_salt6.04829097
5MP0008875_abnormal_xenobiotic_pharmacok5.04559941
6MP0003806_abnormal_nucleotide_metabolis4.13868524
7MP0003252_abnormal_bile_duct3.84870567
8MP0010329_abnormal_lipoprotein_level3.50272990
9MP0009840_abnormal_foam_cell3.16689983
10MP0005083_abnormal_biliary_tract2.99681913
11MP0003195_calcinosis2.90722368
12MP0005332_abnormal_amino_acid2.72046518
13MP0001666_abnormal_nutrient_absorption2.52351631
14MP0002419_abnormal_innate_immunity2.44606122
15MP0003191_abnormal_cellular_cholesterol2.44043545
16MP0003303_peritoneal_inflammation2.31915697
17MP0001835_abnormal_antigen_presentation2.19606593
18MP0004019_abnormal_vitamin_homeostasis2.16374679
19MP0009785_altered_susceptibility_to2.13561677
20MP0000609_abnormal_liver_physiology2.11212518
21MP0005025_abnormal_response_to2.11182674
22MP0002118_abnormal_lipid_homeostasis2.07958496
23MP0005451_abnormal_body_composition1.96245534
24MP0002138_abnormal_hepatobiliary_system1.94605731
25MP0000685_abnormal_immune_system1.92842780
26MP0001800_abnormal_humoral_immune1.91167192
27MP0003868_abnormal_feces_composition1.83646914
28MP0005319_abnormal_enzyme/_coenzyme1.75559818
29MP0004883_abnormal_blood_vessel1.70728938
30MP0005387_immune_system_phenotype1.68237397
31MP0001790_abnormal_immune_system1.68237397
32MP0001764_abnormal_homeostasis1.64908636
33MP0005000_abnormal_immune_tolerance1.63046458
34MP0002723_abnormal_immune_serum1.61125382
35MP0001533_abnormal_skeleton_physiology1.58072881
36MP0002254_reproductive_system_inflammat1.57197196
37MP0008260_abnormal_autophagy1.53705821
38MP0009697_abnormal_copulation1.51220250
39MP0005671_abnormal_response_to1.50933251
40MP0002420_abnormal_adaptive_immunity1.49963157
41MP0005584_abnormal_enzyme/coenzyme_acti1.48887641
42MP0001819_abnormal_immune_cell1.48051207
43MP0001851_eye_inflammation1.45328792
44MP0002452_abnormal_antigen_presenting1.44600052
45MP0000465_gastrointestinal_hemorrhage1.42537159
46MP0005164_abnormal_response_to1.42198119
47MP0003011_delayed_dark_adaptation1.42039791
48MP0003828_pulmonary_edema1.41995685
49MP0003300_gastrointestinal_ulcer1.38894526
50MP0003172_abnormal_lysosome_physiology1.33860199
51MP0002405_respiratory_system_inflammati1.30462441
52MP0003763_abnormal_thymus_physiology1.29587016
53MP0005647_abnormal_sex_gland1.22987533
54MP0003705_abnormal_hypodermis_morpholog1.21105075
55MP0003186_abnormal_redox_activity1.20511274
56MP0002148_abnormal_hypersensitivity_rea1.20139890
57MP0010155_abnormal_intestine_physiology1.18996253
58MP0009643_abnormal_urine_homeostasis1.17130496
59MP0000858_altered_metastatic_potential1.16886430
60MP0002796_impaired_skin_barrier1.16806105
61MP0003656_abnormal_erythrocyte_physiolo1.13168803
62MP0009764_decreased_sensitivity_to1.10003923
63MP0000598_abnormal_liver_morphology1.09662104
64MP0002277_abnormal_respiratory_mucosa1.09153038
65MP0000716_abnormal_immune_system1.07819688
66MP0000604_amyloidosis1.06847285
67MP0002396_abnormal_hematopoietic_system1.06237062
68MP0001545_abnormal_hematopoietic_system1.05578085
69MP0005397_hematopoietic_system_phenotyp1.05578085
70MP0002398_abnormal_bone_marrow1.05560182
71MP0002166_altered_tumor_susceptibility1.04331325
72MP0003878_abnormal_ear_physiology1.01425267
73MP0005377_hearing/vestibular/ear_phenot1.01425267
74MP0009763_increased_sensitivity_to1.01393252
75MP0000689_abnormal_spleen_morphology1.00527228
76MP0001915_intracranial_hemorrhage0.98870090
77MP0009333_abnormal_splenocyte_physiolog0.97617591
78MP0002998_abnormal_bone_remodeling0.96063717
79MP0002722_abnormal_immune_system0.95152790
80MP0003183_abnormal_peptide_metabolism0.94080160
81MP0002876_abnormal_thyroid_physiology0.92869848
82MP0000569_abnormal_digit_pigmentation0.90442726
83MP0004381_abnormal_hair_follicle0.88899460
84MP0008469_abnormal_protein_level0.88422695
85MP0005636_abnormal_mineral_homeostasis0.85754283
86MP0010368_abnormal_lymphatic_system0.84169411
87MP0009642_abnormal_blood_homeostasis0.83222222
88MP0005408_hypopigmentation0.80632452
89MP0009765_abnormal_xenobiotic_induced0.79753836
90MP0002429_abnormal_blood_cell0.78993635
91MP0005670_abnormal_white_adipose0.78547983
92MP0003866_abnormal_defecation0.77893238
93MP0002009_preneoplasia0.77077307
94MP0002971_abnormal_brown_adipose0.75836309
95MP0005058_abnormal_lysosome_morphology0.74980377
96MP0005376_homeostasis/metabolism_phenot0.74938212
97MP0000249_abnormal_blood_vessel0.71595133
98MP0002078_abnormal_glucose_homeostasis0.70824140
99MP0000015_abnormal_ear_pigmentation0.69971226
100MP0005334_abnormal_fat_pad0.69173752
101MP0006036_abnormal_mitochondrial_physio0.67156747
102MP0005084_abnormal_gallbladder_morpholo0.67061521
103MP0003690_abnormal_glial_cell0.66502611
104MP0005409_darkened_coat_color0.65794916
105MP0005220_abnormal_exocrine_pancreas0.65091219
106MP0004782_abnormal_surfactant_physiolog0.64380789
107MP0005535_abnormal_body_temperature0.63616039
108MP0000579_abnormal_nail_morphology0.63297303
109MP0009053_abnormal_anal_canal0.62525125
110MP0001661_extended_life_span0.62218009
111MP0003329_amyloid_beta_deposits0.61190831
112MP0004130_abnormal_muscle_cell0.61131650
113MP0002060_abnormal_skin_morphology0.61101204
114MP0010234_abnormal_vibrissa_follicle0.60137676
115MP0005266_abnormal_metabolism0.57059705
116MP0005448_abnormal_energy_balance0.55510137
117MP0005464_abnormal_platelet_physiology0.54841759
118MP0003436_decreased_susceptibility_to0.54160914
119MP0000639_abnormal_adrenal_gland0.54126534
120MP0003724_increased_susceptibility_to0.52445991
121MP0001756_abnormal_urination0.51757285
122MP0003638_abnormal_response/metabolism_0.51466375
123MP0005501_abnormal_skin_physiology0.50840909
124MP0003453_abnormal_keratinocyte_physiol0.47433802
125MP0005395_other_phenotype0.46484045
126MP0004947_skin_inflammation0.46079017
127MP0003718_maternal_effect0.46035199
128MP0008874_decreased_physiological_sensi0.45407767
129MP0006035_abnormal_mitochondrial_morpho0.44923420
130MP0006082_CNS_inflammation0.44749718
131MP0001243_abnormal_dermal_layer0.43826626
132MP0002136_abnormal_kidney_physiology0.43473283
133MP0000427_abnormal_hair_cycle0.43230280
134MP0002822_catalepsy0.42544936
135MP0005248_abnormal_Harderian_gland0.41202039
136MP0008873_increased_physiological_sensi0.41006073
137MP0003075_altered_response_to0.40962979
138MP0002928_abnormal_bile_duct0.39542825
139MP0005666_abnormal_adipose_tissue0.39123227
140MP0001216_abnormal_epidermal_layer0.38840792
141MP0005275_abnormal_skin_tensile0.37530656
142MP0005166_decreased_susceptibility_to0.36218271
143MP0003953_abnormal_hormone_level0.35853851
144MP0000647_abnormal_sebaceous_gland0.33800069
145MP0009384_cardiac_valve_regurgitation0.33480425
146MP0009115_abnormal_fat_cell0.33471326
147MP0009672_abnormal_birth_weight0.33034304
148MP0001853_heart_inflammation0.32562115
149MP0009931_abnormal_skin_appearance0.31222258
150MP0002132_abnormal_respiratory_system0.30969174
151MP0001845_abnormal_inflammatory_respons0.30882982
152MP0008872_abnormal_physiological_respon0.30105889

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.42400096
2Intrahepatic cholestasis (HP:0001406)7.41340801
3Deep venous thrombosis (HP:0002625)7.37339863
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.80038808
5Prolonged partial thromboplastin time (HP:0003645)6.68386312
6Hypobetalipoproteinemia (HP:0003563)6.35410230
7Xanthomatosis (HP:0000991)6.28398012
8Hyperlipoproteinemia (HP:0010980)5.55653912
9Complement deficiency (HP:0004431)5.52053527
10Eczematoid dermatitis (HP:0000976)5.50983831
11Joint hemorrhage (HP:0005261)4.92926792
12Increased IgE level (HP:0003212)4.82854275
13Hypolipoproteinemia (HP:0010981)4.73427626
14Epidermoid cyst (HP:0200040)4.61619724
15Hyperammonemia (HP:0001987)4.53087393
16Myositis (HP:0100614)4.39918218
17Abnormality of the common coagulation pathway (HP:0010990)4.39321722
18Orchitis (HP:0100796)4.38713383
19Hyperglycinemia (HP:0002154)4.35705548
20Abnormality of methionine metabolism (HP:0010901)4.35067347
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.34999094
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.29471618
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.28283462
24Optic neuritis (HP:0100653)4.22349925
25Retrobulbar optic neuritis (HP:0100654)4.22349925
26Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15770736
27Fat malabsorption (HP:0002630)4.15651414
28Hypoalphalipoproteinemia (HP:0003233)4.12477593
29Abnormality of complement system (HP:0005339)4.11601851
30Ketosis (HP:0001946)4.08939111
31Gangrene (HP:0100758)3.97558075
32Recurrent bacterial skin infections (HP:0005406)3.95337128
33Abnormality of pyrimidine metabolism (HP:0004353)3.91291256
34Hyperglycinuria (HP:0003108)3.90214970
35Abnormality of glycine metabolism (HP:0010895)3.86664137
36Abnormality of serine family amino acid metabolism (HP:0010894)3.86664137
37Recurrent abscess formation (HP:0002722)3.85775190
38Conjugated hyperbilirubinemia (HP:0002908)3.83424232
39Abnormality of the intrinsic pathway (HP:0010989)3.68208460
40Hypoglycemic coma (HP:0001325)3.64077927
41Hypercholesterolemia (HP:0003124)3.62257930
42Keratoconjunctivitis sicca (HP:0001097)3.51092108
43Gastrointestinal infarctions (HP:0005244)3.36568674
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27080473
45Hyperbilirubinemia (HP:0002904)3.26166709
46Abnormality of fatty-acid metabolism (HP:0004359)3.23481097
47Keratoconjunctivitis (HP:0001096)3.19318055
48Steatorrhea (HP:0002570)3.16862764
49Recurrent skin infections (HP:0001581)3.11223965
50Myocardial infarction (HP:0001658)3.08499262
51Delayed CNS myelination (HP:0002188)3.07262026
52Systemic lupus erythematosus (HP:0002725)3.06077912
53Abnormality of nucleobase metabolism (HP:0010932)3.04208564
54Epistaxis (HP:0000421)3.04165491
55Abnormality of serum amino acid levels (HP:0003112)3.04085435
56Abnormality of macrophages (HP:0004311)2.99247176
57Abnormality of secondary sexual hair (HP:0009888)2.98458684
58Abnormality of the axillary hair (HP:0100134)2.98458684
59Spontaneous hematomas (HP:0007420)2.93824584
60Hypochromic microcytic anemia (HP:0004840)2.90159967
61Spontaneous abortion (HP:0005268)2.89284934
62Hepatocellular carcinoma (HP:0001402)2.88021713
63Meningitis (HP:0001287)2.83607728
64Ketoacidosis (HP:0001993)2.82087086
65Peritonitis (HP:0002586)2.80792366
66Skin nodule (HP:0200036)2.76941345
67Stomatitis (HP:0010280)2.73560145
68Gingivitis (HP:0000230)2.72639209
69Purpura (HP:0000979)2.72152697
70Urticaria (HP:0001025)2.71098225
71Hypochromic anemia (HP:0001931)2.70054922
72Metabolic acidosis (HP:0001942)2.68256877
73Vascular calcification (HP:0004934)2.66799126
74Prolonged bleeding time (HP:0003010)2.65664472
75Elevated erythrocyte sedimentation rate (HP:0003565)2.64222484
76Abnormality of nail color (HP:0100643)2.61126975
77Glomerulonephritis (HP:0000099)2.61061603
78Abnormality of purine metabolism (HP:0004352)2.60667218
79Anorexia (HP:0002039)2.56546792
80Arterial thrombosis (HP:0004420)2.55485815
81Lethargy (HP:0001254)2.52374791
82Recurrent gram-negative bacterial infections (HP:0005420)2.50777148
83Mitral stenosis (HP:0001718)2.49597858
84Chronic obstructive pulmonary disease (HP:0006510)2.49120843
85Obstructive lung disease (HP:0006536)2.49120843
86Acanthocytosis (HP:0001927)2.48877383
87Dicarboxylic aciduria (HP:0003215)2.48024485
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48024485
89Abnormal gallbladder morphology (HP:0012437)2.44459860
90Amyloidosis (HP:0011034)2.38596280
91Neonatal onset (HP:0003623)2.38129951
92Cerebral edema (HP:0002181)2.37387394
93Cholelithiasis (HP:0001081)2.36597530
94Cardiovascular calcification (HP:0011915)2.36318474
95Vasculitis (HP:0002633)2.35449925
96Encephalitis (HP:0002383)2.34933329
97Joint swelling (HP:0001386)2.34107174
98Spastic diplegia (HP:0001264)2.33289401
99Irritability (HP:0000737)2.31994447
100Hypoglycemic seizures (HP:0002173)2.30989822
101Erythroderma (HP:0001019)2.30634967
102Recurrent fungal infections (HP:0002841)2.29025257
103Palmoplantar hyperkeratosis (HP:0000972)2.27820610
104Mediastinal lymphadenopathy (HP:0100721)2.27458918
105Malnutrition (HP:0004395)2.27167710
106Gout (HP:0001997)2.25116178
107Gingival bleeding (HP:0000225)2.24365852
108Cholecystitis (HP:0001082)2.23387519
109Abnormal gallbladder physiology (HP:0012438)2.23387519
110Menorrhagia (HP:0000132)2.20802373
111Hemoptysis (HP:0002105)2.20378327
112Esophageal varix (HP:0002040)2.17390403
113Osteomalacia (HP:0002749)2.17364123
114Pustule (HP:0200039)2.15596746
115Palmar hyperkeratosis (HP:0010765)2.14188986
116Pancreatitis (HP:0001733)2.13206317
117Brushfield spots (HP:0001088)2.11136994
118Increased serum ferritin (HP:0003281)2.10059874
119Abnormal delayed hypersensitivity skin test (HP:0002963)2.08708713
120Erythema (HP:0010783)2.08129333
121Enlarged kidneys (HP:0000105)2.05647090
122Thrombophlebitis (HP:0004418)2.04266419
123Thick nail (HP:0001805)2.03122907
124Episodic fever (HP:0001954)2.02690337
125Pulmonary infiltrates (HP:0002113)2.02622453
126Opisthotonus (HP:0002179)2.02137701
127Sensorimotor neuropathy (HP:0007141)2.01968019
128Hemorrhage of the eye (HP:0011885)2.01290193
129Rickets (HP:0002748)2.00921579
130Periodontitis (HP:0000704)2.00610322
131Abnormality of the gallbladder (HP:0005264)2.00024832
132Vomiting (HP:0002013)1.99743470
133Abnormal platelet volume (HP:0011876)1.99161742
134Hypophosphatemic rickets (HP:0004912)1.99148863
135Abnormality of proline metabolism (HP:0010907)1.98910005
136Hydroxyprolinuria (HP:0003080)1.98910005
137Late onset (HP:0003584)1.98275880
138Hypotrichosis (HP:0001006)1.97015805
139Generalized aminoaciduria (HP:0002909)1.94084825
140Poikilocytosis (HP:0004447)1.93215108
141Renal cortical cysts (HP:0000803)1.92770195
142Pruritus (HP:0000989)1.88628185
143Fair hair (HP:0002286)1.88526688
144Recurrent cutaneous fungal infections (HP:0011370)1.87203075
145Chronic mucocutaneous candidiasis (HP:0002728)1.87203075
146Chest pain (HP:0100749)1.87013306
147Hyperinsulinemic hypoglycemia (HP:0000825)1.86521963
148Nephritis (HP:0000123)1.85357370
149Abnormality of iron homeostasis (HP:0011031)1.84286313
150Abnormal enzyme/coenzyme activity (HP:0012379)1.83190049
151Polycythemia (HP:0001901)1.82891833
152Hypergammaglobulinemia (HP:0010702)1.82786337
153Alkalosis (HP:0001948)1.82142178
154Abnormality of the peritoneum (HP:0002585)1.81806376
155Abnormality of transition element cation homeostasis (HP:0011030)1.81178345
156Parakeratosis (HP:0001036)1.81002218
157Dry hair (HP:0011359)1.77514318
158Premature loss of primary teeth (HP:0006323)1.77162098
159Abnormality of the pleura (HP:0002103)1.77072500
160Elevated hepatic transaminases (HP:0002910)1.76786695
161Acne (HP:0001061)1.76396126
162Abnormal cartilage morphology (HP:0002763)1.76367928
163Status epilepticus (HP:0002133)1.72384369
164Abnormality of vitamin metabolism (HP:0100508)1.71506191
165Pulmonary embolism (HP:0002204)1.71477346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.63140841
2FGFR44.62838580
3SIK14.49149856
4ERN14.20573583
5RIPK43.95407079
6INSRR3.12919557
7TAOK33.06287513
8ERBB42.94057528
9IRAK42.92033002
10MST1R2.84524805
11MAP4K12.41402791
12STK242.37358234
13MAP2K42.26139201
14FES2.03843218
15PIK3CG1.97774226
16TNK21.88202241
17ZAP701.87103151
18TYK21.83576880
19MAPK111.78376786
20LATS11.68537331
21PKN21.60738114
22PRPF4B1.57987385
23MAP3K141.57860188
24KIT1.57221235
25FLT31.55413329
26DAPK21.48094603
27PTK61.47645929
28HCK1.46249175
29BTK1.44161470
30FGFR21.43741422
31KSR21.43740085
32JAK31.39297166
33ABL21.38496363
34SYK1.37532244
35FGR1.34299515
36NEK91.32500225
37MAP3K71.31973044
38YES11.28441413
39TXK1.25977917
40TAOK11.25524333
41TRIB31.24219094
42JAK21.22141748
43PINK11.21073900
44FRK1.20170944
45TBK11.18338714
46PRKAA21.17616277
47MAP3K31.09941543
48LYN1.08940205
49KDR1.08825825
50MAPK151.08414754
51NLK1.06608926
52EPHA31.06260117
53EPHB11.05377047
54JAK11.03730544
55MET1.02655875
56ERBB21.00047582
57MAP2K30.96632591
58MAPK40.96382985
59IRAK30.96064153
60PDK10.93195379
61GRK60.92749379
62DYRK1B0.91631928
63MARK20.91571112
64LCK0.89292250
65PRKCZ0.87892942
66SIK30.84833985
67TEC0.82708967
68MAPK120.82668650
69MARK30.81272491
70STK38L0.81051128
71CSK0.79960454
72CDK60.79018697
73LRRK20.75485121
74GRK10.75435469
75BLK0.74952732
76MAP3K110.74072642
77PRKACG0.73146027
78IKBKE0.73130935
79STK100.71777909
80TIE10.71712465
81MAP2K60.71598203
82MAP3K100.71384917
83TGFBR20.71284383
84CAMK1D0.70340239
85MATK0.69055865
86RAF10.67729575
87CAMK2G0.67706203
88GSK3A0.67121284
89PKN10.66801908
90FGFR30.66374508
91WNK10.66296488
92MAPK70.65049459
93BMPR20.62146477
94STK110.60996795
95CDK120.60230952
96PRKCQ0.55737888
97PRKAA10.54317843
98SGK30.53216987
99CAMKK20.53068334
100PBK0.52475918
101TAOK20.51621347
102PTK20.50676461
103CSF1R0.49260128
104FYN0.48789581
105IGF1R0.48507599
106MAP3K130.46905701
107MAP3K60.44859070
108IRAK10.44727253
109RIPK10.43777375
110ICK0.43662148
111EPHA40.42904509
112HIPK20.41530720
113CSNK1G10.40231730
114PRKD20.40161029
115SGK20.40075786
116PDPK10.39843745
117SIK20.38747428
118MOS0.38535800
119MAPKAPK20.38272824
120MAP2K10.37875792
121STK380.37069939
122EGFR0.35678699
123MAP3K50.35470771
124KSR10.35109821
125ITK0.34783686
126TRPM70.34421580
127PRKCG0.34216321
128GRK70.34173438
129IRAK20.33898347
130MAP3K10.30710468
131FER0.29753204
132BMX0.29590963
133IKBKB0.29502149
134FGFR10.28562567
135PRKCA0.28289417
136CAMK40.27825672
137ABL10.27471350
138CDK40.27370291
139MAPKAPK30.27022922
140MAP3K20.26229278
141CHUK0.24797691
142EPHB20.24387613
143RET0.24143989
144SGK2230.23589025
145SGK4940.23589025
146MAP2K20.22309897

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56083400
2Nitrogen metabolism_Homo sapiens_hsa009103.58934259
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38156356
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31227386
5Arginine biosynthesis_Homo sapiens_hsa002203.13278960
6Complement and coagulation cascades_Homo sapiens_hsa046102.83003656
7Tryptophan metabolism_Homo sapiens_hsa003802.70353759
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59209532
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56156593
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54434802
11Fatty acid degradation_Homo sapiens_hsa000712.41347243
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33510877
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26712674
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20102773
15Peroxisome_Homo sapiens_hsa041462.06922095
16Butanoate metabolism_Homo sapiens_hsa006502.06669677
17Chemical carcinogenesis_Homo sapiens_hsa052042.00370596
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98746052
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.98528186
20Staphylococcus aureus infection_Homo sapiens_hsa051501.93367351
21Propanoate metabolism_Homo sapiens_hsa006401.85181480
22Caffeine metabolism_Homo sapiens_hsa002321.84556045
23* Histidine metabolism_Homo sapiens_hsa003401.83671352
24PPAR signaling pathway_Homo sapiens_hsa033201.82578653
25Retinol metabolism_Homo sapiens_hsa008301.78849241
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.75547973
27Leishmaniasis_Homo sapiens_hsa051401.73169482
28Fatty acid metabolism_Homo sapiens_hsa012121.73129803
29beta-Alanine metabolism_Homo sapiens_hsa004101.73012456
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72380835
31Osteoclast differentiation_Homo sapiens_hsa043801.68755970
32Phenylalanine metabolism_Homo sapiens_hsa003601.66244271
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65282294
34Selenocompound metabolism_Homo sapiens_hsa004501.54965143
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52502327
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51398017
37Tyrosine metabolism_Homo sapiens_hsa003501.51109069
38Bile secretion_Homo sapiens_hsa049761.44329001
39Fatty acid elongation_Homo sapiens_hsa000621.40848427
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38840407
41Sulfur metabolism_Homo sapiens_hsa009201.34703829
42ABC transporters_Homo sapiens_hsa020101.29079344
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.28092599
44Steroid biosynthesis_Homo sapiens_hsa001001.27492499
45Pyruvate metabolism_Homo sapiens_hsa006201.26304686
46Starch and sucrose metabolism_Homo sapiens_hsa005001.25281737
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21841005
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21371000
49Folate biosynthesis_Homo sapiens_hsa007901.19985148
50Tuberculosis_Homo sapiens_hsa051521.18555348
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.15246699
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14849099
53Biosynthesis of amino acids_Homo sapiens_hsa012301.14415749
54B cell receptor signaling pathway_Homo sapiens_hsa046621.14299116
55Fat digestion and absorption_Homo sapiens_hsa049751.14261944
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11357309
57NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03463778
58Carbon metabolism_Homo sapiens_hsa012001.02585734
59Malaria_Homo sapiens_hsa051441.02162708
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00389121
61Acute myeloid leukemia_Homo sapiens_hsa052210.98191909
62Arginine and proline metabolism_Homo sapiens_hsa003300.95576424
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.95316422
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94270142
65Vitamin B6 metabolism_Homo sapiens_hsa007500.92502452
66Sulfur relay system_Homo sapiens_hsa041220.89503873
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89230811
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86871918
69Platelet activation_Homo sapiens_hsa046110.85759173
70Vitamin digestion and absorption_Homo sapiens_hsa049770.85668949
71Measles_Homo sapiens_hsa051620.78636363
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78098695
73Legionellosis_Homo sapiens_hsa051340.77300959
74Lysine degradation_Homo sapiens_hsa003100.76617019
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.76247594
76Chemokine signaling pathway_Homo sapiens_hsa040620.76094932
77One carbon pool by folate_Homo sapiens_hsa006700.72791016
78Other glycan degradation_Homo sapiens_hsa005110.72374960
79Hematopoietic cell lineage_Homo sapiens_hsa046400.72000051
80Influenza A_Homo sapiens_hsa051640.71452719
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.66758160
82Glutathione metabolism_Homo sapiens_hsa004800.66298172
83Glycerolipid metabolism_Homo sapiens_hsa005610.65275789
84Graft-versus-host disease_Homo sapiens_hsa053320.63613466
85Non-small cell lung cancer_Homo sapiens_hsa052230.63612615
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62712282
87Dorso-ventral axis formation_Homo sapiens_hsa043200.61978016
88Phagosome_Homo sapiens_hsa041450.61383815
89T cell receptor signaling pathway_Homo sapiens_hsa046600.60402995
90Toxoplasmosis_Homo sapiens_hsa051450.58679906
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58097500
92Fatty acid biosynthesis_Homo sapiens_hsa000610.56905267
93Primary immunodeficiency_Homo sapiens_hsa053400.56748196
94Allograft rejection_Homo sapiens_hsa053300.55844627
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.54546701
96VEGF signaling pathway_Homo sapiens_hsa043700.53550547
97Herpes simplex infection_Homo sapiens_hsa051680.51688616
98Autoimmune thyroid disease_Homo sapiens_hsa053200.51135232
99Pancreatic cancer_Homo sapiens_hsa052120.49827236
100Pentose phosphate pathway_Homo sapiens_hsa000300.49418358
101TNF signaling pathway_Homo sapiens_hsa046680.49309242
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48775976
103FoxO signaling pathway_Homo sapiens_hsa040680.48276076
104Choline metabolism in cancer_Homo sapiens_hsa052310.47552634
105* Metabolic pathways_Homo sapiens_hsa011000.45450478
106Hepatitis B_Homo sapiens_hsa051610.40139065
107Prolactin signaling pathway_Homo sapiens_hsa049170.39623982
108Linoleic acid metabolism_Homo sapiens_hsa005910.38578744
109Prion diseases_Homo sapiens_hsa050200.37459820
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36996121
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33560740
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31666192
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31611921
114GnRH signaling pathway_Homo sapiens_hsa049120.30265161
115Renal cell carcinoma_Homo sapiens_hsa052110.30171996
116Antigen processing and presentation_Homo sapiens_hsa046120.30019507
117Chronic myeloid leukemia_Homo sapiens_hsa052200.29111526
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28814013
119Inositol phosphate metabolism_Homo sapiens_hsa005620.26792899
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.21558706
121Insulin resistance_Homo sapiens_hsa049310.20707242
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19583099
123Galactose metabolism_Homo sapiens_hsa000520.18929275
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.18536380
125Fructose and mannose metabolism_Homo sapiens_hsa000510.15067988
126Glucagon signaling pathway_Homo sapiens_hsa049220.04895775
127Arachidonic acid metabolism_Homo sapiens_hsa005900.01168132
128Lysosome_Homo sapiens_hsa04142-0.2527299
129Bladder cancer_Homo sapiens_hsa05219-0.2503200
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2493725
131Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2443257
132Renin-angiotensin system_Homo sapiens_hsa04614-0.2166920
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2132174
134Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2087326
135Amoebiasis_Homo sapiens_hsa05146-0.1977488
136Pertussis_Homo sapiens_hsa05133-0.1796189
137Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1546090
138Hepatitis C_Homo sapiens_hsa05160-0.1467208
139Insulin signaling pathway_Homo sapiens_hsa04910-0.1425195
140Ether lipid metabolism_Homo sapiens_hsa00565-0.1343270
141Regulation of autophagy_Homo sapiens_hsa04140-0.1147915
142African trypanosomiasis_Homo sapiens_hsa05143-0.1128403
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1062025
144Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0905792
145Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0902014
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0619431
147Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0408348
148AMPK signaling pathway_Homo sapiens_hsa04152-0.0186865

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