HADHA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1carnitine shuttle (GO:0006853)5.93067251
2tricarboxylic acid cycle (GO:0006099)5.75310406
3fatty acid transmembrane transport (GO:1902001)5.74749354
4lysine metabolic process (GO:0006553)5.58036949
5lysine catabolic process (GO:0006554)5.58036949
6Golgi transport vesicle coating (GO:0048200)5.13393681
7COPI coating of Golgi vesicle (GO:0048205)5.13393681
8* fatty acid beta-oxidation (GO:0006635)5.11601163
92-oxoglutarate metabolic process (GO:0006103)5.04877651
10regulation of sequestering of triglyceride (GO:0010889)5.04013666
11sarcomere organization (GO:0045214)4.78178239
12carnitine transmembrane transport (GO:1902603)4.66558955
13aspartate family amino acid catabolic process (GO:0009068)4.59525780
14regulation of fatty acid oxidation (GO:0046320)4.58758987
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.52345290
16alpha-linolenic acid metabolic process (GO:0036109)4.52183040
17* fatty acid oxidation (GO:0019395)4.51089906
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.50462745
19cardiac myofibril assembly (GO:0055003)4.49241579
20regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.47161167
21amino-acid betaine transport (GO:0015838)4.46297653
22carnitine transport (GO:0015879)4.46297653
23* fatty acid catabolic process (GO:0009062)4.44608978
24acetyl-CoA metabolic process (GO:0006084)4.43819079
25positive regulation of fatty acid beta-oxidation (GO:0032000)4.43675227
26* lipid oxidation (GO:0034440)4.42151324
27glyoxylate metabolic process (GO:0046487)4.34981119
28regulation of triglyceride catabolic process (GO:0010896)4.33590534
29amino-acid betaine metabolic process (GO:0006577)4.27591207
30carnitine metabolic process (GO:0009437)4.26156967
31positive regulation of fatty acid oxidation (GO:0046321)4.22328670
32NADH metabolic process (GO:0006734)4.18508483
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.18485868
34L-phenylalanine metabolic process (GO:0006558)4.18485868
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.15819815
36L-phenylalanine catabolic process (GO:0006559)4.15819815
37short-chain fatty acid metabolic process (GO:0046459)4.14937013
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.14274935
39cellular ketone body metabolic process (GO:0046950)4.13140686
40valine metabolic process (GO:0006573)4.12601704
41negative regulation of potassium ion transmembrane transport (GO:1901380)4.05502804
42tricarboxylic acid metabolic process (GO:0072350)4.05087168
43bundle of His cell to Purkinje myocyte communication (GO:0086069)4.04555791
44branched-chain amino acid catabolic process (GO:0009083)4.03813306
45biotin metabolic process (GO:0006768)4.01189942
46* monocarboxylic acid catabolic process (GO:0072329)3.98220834
47low-density lipoprotein particle clearance (GO:0034383)3.94792569
48myofibril assembly (GO:0030239)3.94110421
49regulation of acyl-CoA biosynthetic process (GO:0050812)3.93554443
50kynurenine metabolic process (GO:0070189)3.92420392
51regulation of fatty acid beta-oxidation (GO:0031998)3.81702622
52branched-chain amino acid metabolic process (GO:0009081)3.76805831
53very-low-density lipoprotein particle assembly (GO:0034379)3.75722438
54pentose-phosphate shunt (GO:0006098)3.75326257
55oxaloacetate metabolic process (GO:0006107)3.66412116
56proline biosynthetic process (GO:0006561)3.66060082
57succinate metabolic process (GO:0006105)3.63053002
58ketone body metabolic process (GO:1902224)3.59808533
59negative regulation of fatty acid biosynthetic process (GO:0045717)3.59639459
60regulation of coenzyme metabolic process (GO:0051196)3.59278823
61regulation of cofactor metabolic process (GO:0051193)3.59278823
62aromatic amino acid family catabolic process (GO:0009074)3.58920066
63phospholipid homeostasis (GO:0055091)3.58865849
64ethanol oxidation (GO:0006069)3.55223704
65NADPH regeneration (GO:0006740)3.54684733
66positive regulation of lipid catabolic process (GO:0050996)3.53989376
67quaternary ammonium group transport (GO:0015697)3.52588471
68muscle filament sliding (GO:0030049)3.49208207
69actin-myosin filament sliding (GO:0033275)3.49208207
70sulfur amino acid catabolic process (GO:0000098)3.48360395
71cardiac muscle contraction (GO:0060048)3.46967537
72regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.43950656
73ventricular cardiac muscle cell action potential (GO:0086005)3.42975458
74pinocytosis (GO:0006907)3.42418008
75COPII vesicle coating (GO:0048208)3.41728816
76nitrogen cycle metabolic process (GO:0071941)3.38901795
77creatine metabolic process (GO:0006600)3.38887101
78cardiac muscle cell development (GO:0055013)3.35579638
79positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.32613267
80glycosphingolipid catabolic process (GO:0046479)3.32127210
81angiotensin maturation (GO:0002003)3.31794944
82plasma lipoprotein particle clearance (GO:0034381)3.31475214
83fatty acid homeostasis (GO:0055089)3.28519804
84bile acid biosynthetic process (GO:0006699)3.27757172
85homocysteine metabolic process (GO:0050667)3.27615267
86acylglycerol homeostasis (GO:0055090)3.25907126
87triglyceride homeostasis (GO:0070328)3.25907126
88negative regulation of fatty acid metabolic process (GO:0045922)3.25733579
89fructose metabolic process (GO:0006000)3.25731977
90regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.25239809
91* carboxylic acid catabolic process (GO:0046395)3.25075471
92* organic acid catabolic process (GO:0016054)3.25075471
93dicarboxylic acid biosynthetic process (GO:0043650)3.22128168
94alpha-amino acid catabolic process (GO:1901606)3.21738574
95cysteine metabolic process (GO:0006534)3.21113668
96regulation of cholesterol metabolic process (GO:0090181)3.19851920
97serine family amino acid catabolic process (GO:0009071)3.18845519
98intracellular lipid transport (GO:0032365)3.17994658
99complement activation, alternative pathway (GO:0006957)3.16870093
100tryptophan catabolic process (GO:0006569)3.15562387
101indole-containing compound catabolic process (GO:0042436)3.15562387
102indolalkylamine catabolic process (GO:0046218)3.15562387
103protein-lipid complex assembly (GO:0065005)3.15300749
104heart trabecula formation (GO:0060347)3.13750858
105cardiac cell development (GO:0055006)3.13590488
106urea cycle (GO:0000050)3.12961692
107urea metabolic process (GO:0019627)3.12961692
108negative regulation of fibrinolysis (GO:0051918)3.12000053
109regulation of skeletal muscle contraction (GO:0014819)3.11951997
110regulation of sulfur metabolic process (GO:0042762)3.11475510
111plasma lipoprotein particle assembly (GO:0034377)3.11193814
112regulation of cholesterol esterification (GO:0010872)3.10654593
113glycolipid catabolic process (GO:0019377)3.10433125
114peptidyl-glutamic acid carboxylation (GO:0017187)3.08814684
115protein carboxylation (GO:0018214)3.08814684
116cellular amino acid catabolic process (GO:0009063)3.08302088
117positive regulation of triglyceride metabolic process (GO:0090208)3.08245672
118retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.08034336
119glucose catabolic process (GO:0006007)3.04640687
120plasma membrane repair (GO:0001778)3.04496689
121glucose 6-phosphate metabolic process (GO:0051156)3.03027638
122regulation of cholesterol homeostasis (GO:2000188)3.02005849
123gluconeogenesis (GO:0006094)2.99055947
124response to thyroid hormone (GO:0097066)2.97652462
125regulation of cholesterol storage (GO:0010885)2.94486442
126formation of translation preinitiation complex (GO:0001731)2.93079363
127monosaccharide biosynthetic process (GO:0046364)2.91897106
128negative regulation of erythrocyte differentiation (GO:0045647)2.90874210
129oligosaccharide catabolic process (GO:0009313)2.85287189
130protoporphyrinogen IX metabolic process (GO:0046501)2.82774338
131glutamine family amino acid biosynthetic process (GO:0009084)2.80680163
132hexose biosynthetic process (GO:0019319)2.79737939
133phospholipid efflux (GO:0033700)2.71839617
134intestinal absorption (GO:0050892)2.69981655
135triglyceride catabolic process (GO:0019433)2.69057952
136proline metabolic process (GO:0006560)2.67145528
137barbed-end actin filament capping (GO:0051016)2.66306785
138cellular response to thyroid hormone stimulus (GO:0097067)2.66017921
139vesicle coating (GO:0006901)2.62579380
140actin-mediated cell contraction (GO:0070252)2.58687477
141epoxygenase P450 pathway (GO:0019373)2.55193895
142regulation of protein activation cascade (GO:2000257)2.54352150
143cellular hyperosmotic response (GO:0071474)2.53981496
144positive regulation of lipoprotein lipase activity (GO:0051006)2.52190928
145positive regulation of triglyceride lipase activity (GO:0061365)2.52190928
146protein-lipid complex subunit organization (GO:0071825)2.51983427
147peptide catabolic process (GO:0043171)2.51374854
148regulation of complement activation (GO:0030449)2.51372090
149protein-lipid complex remodeling (GO:0034368)2.50619119
150macromolecular complex remodeling (GO:0034367)2.50619119
151plasma lipoprotein particle remodeling (GO:0034369)2.50619119
152regulation of translational fidelity (GO:0006450)2.50356605
153acylglycerol catabolic process (GO:0046464)2.49615680
154neutral lipid catabolic process (GO:0046461)2.49615680
155low-density lipoprotein particle remodeling (GO:0034374)2.48839649
156ceramide catabolic process (GO:0046514)2.48197178
157fat-soluble vitamin biosynthetic process (GO:0042362)2.46902028
158acyl-CoA biosynthetic process (GO:0071616)2.46309881
159thioester biosynthetic process (GO:0035384)2.46309881
160plasma lipoprotein particle organization (GO:0071827)2.45778730
161nuclear pore complex assembly (GO:0051292)2.45660406
162regulation of fatty acid biosynthetic process (GO:0042304)2.44282064
163desmosome organization (GO:0002934)2.42831625
164maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41115010
165regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.40665422
166oxidative phosphorylation (GO:0006119)2.40438450
167linoleic acid metabolic process (GO:0043651)2.40239639
168regulation of cholesterol biosynthetic process (GO:0045540)2.38948745
169glycolytic process (GO:0006096)2.38768780
170nucleoside diphosphate biosynthetic process (GO:0009133)2.38521451
171triglyceride metabolic process (GO:0006641)2.36521333

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.61869356
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.54731764
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.91190263
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.45736865
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.86480670
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.43913434
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.84193973
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.49618211
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.49046198
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00648669
11E2F7_22180533_ChIP-Seq_HELA_Human2.87775821
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.79404462
13CLOCK_20551151_ChIP-Seq_293T_Human2.74995380
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.53431595
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43290046
16ZNF263_19887448_ChIP-Seq_K562_Human2.40758189
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.40382918
18TBX20_22080862_ChIP-Seq_HEART_Mouse2.30490814
19TBX20_22328084_ChIP-Seq_HEART_Mouse2.30490814
20EP300_21415370_ChIP-Seq_HL-1_Mouse2.09606044
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.92186921
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74857140
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74315924
24GATA1_22025678_ChIP-Seq_K562_Human1.73719816
25AR_21909140_ChIP-Seq_LNCAP_Human1.72095165
26* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.69493630
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.69214464
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64305327
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.64141348
30MYC_22102868_ChIP-Seq_BL_Human1.63564598
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59680157
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56455950
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55384648
34VDR_21846776_ChIP-Seq_THP-1_Human1.55122734
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.53070991
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51526387
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50116808
38* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.45508548
39TFEB_21752829_ChIP-Seq_HELA_Human1.42330805
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38480627
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38070568
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37476987
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37012991
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36278482
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35716114
46GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34687848
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34393909
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33882557
49* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33832049
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33047182
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.29847341
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28880832
53* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25022486
54* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24051575
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23143897
56NCOR1_26117541_ChIP-Seq_K562_Human1.22891080
57TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21702430
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18988260
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18347898
60* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17773638
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16422294
62* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.15894093
63* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15021491
64* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15010587
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14952589
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14135143
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13961984
68HNF4A_19822575_ChIP-Seq_HepG2_Human1.13801539
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13677117
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12286204
71CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10855913
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10114169
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10089084
74E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09882691
75* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09255777
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08164073
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07580710
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06505678
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06374031
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06143285
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06080494
82LXR_22292898_ChIP-Seq_THP-1_Human1.05666868
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.03767417
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03200470
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03059694
86TCF7_22412390_ChIP-Seq_EML_Mouse1.02220320
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01291607
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00790491
89* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00647478
90VDR_24763502_ChIP-Seq_THP-1_Human1.00083647
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99382576
92RACK7_27058665_Chip-Seq_MCF-7_Human0.99129792
93MAF_26560356_Chip-Seq_TH1_Human0.98928567
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97755845
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97551645
96RUNX1_22412390_ChIP-Seq_EML_Mouse0.97384531
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97262794
98GATA1_19941826_ChIP-Seq_K562_Human0.97109360
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.97078472
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95812183
101* SRF_21415370_ChIP-Seq_HL-1_Mouse0.95424493
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94147548
103SPI1_23127762_ChIP-Seq_K562_Human0.93871551
104ATF3_27146783_Chip-Seq_COLON_Human0.93841133
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93416535
106* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93399249
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93037166
108TP63_17297297_ChIP-ChIP_HaCaT_Human0.92675258
109GATA4_25053715_ChIP-Seq_YYC3_Human0.88220639
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85809872
111TRIM28_21343339_ChIP-Seq_HEK293_Human0.85631447
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.84566827
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84444343
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82907969
115GATA2_19941826_ChIP-Seq_K562_Human0.82297754
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81597225
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79147112
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79104721
119GATA2_21666600_ChIP-Seq_HMVEC_Human0.78236979
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.77537329
121GATA6_25053715_ChIP-Seq_YYC3_Human0.76452322
122BCOR_27268052_Chip-Seq_Bcells_Human0.76066074
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75635200
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75371760
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.75341974
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.75206453
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.75123059
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75100930
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74317080
130P68_20966046_ChIP-Seq_HELA_Human0.73464904
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.72246220
132TP63_22573176_ChIP-Seq_HFKS_Human0.71192068
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70458513
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70200303
135CEBPB_22108803_ChIP-Seq_LS180_Human0.68544705
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.68422140
137FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.67821265
138SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66854617
139SPI1_20517297_ChIP-Seq_HL60_Human0.66804777
140IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.66792771
141BCL6_27268052_Chip-Seq_Bcells_Human0.66139396
142RXRA_24833708_ChIP-Seq_LIVER_Mouse0.65728212
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.64755408
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.64623654
145KDM2B_26808549_Chip-Seq_DND41_Human0.64079978
146EGR1_19032775_ChIP-ChIP_M12_Human0.64060353
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.63881327
148GATA3_24758297_ChIP-Seq_MCF-7_Human0.63833511
149* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.63570324
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62793733
151KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.62602469
152CTCF_21964334_Chip-Seq_Bcells_Human0.62538713
153* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.61014845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.01385964
2MP0002139_abnormal_hepatobiliary_system4.20396439
3MP0005360_urolithiasis4.01998149
4MP0003646_muscle_fatigue3.88240115
5MP0004084_abnormal_cardiac_muscle3.74807089
6MP0005085_abnormal_gallbladder_physiolo3.60055307
7MP0005365_abnormal_bile_salt3.39447545
8MP0000751_myopathy3.07613093
9MP0004215_abnormal_myocardial_fiber3.02843735
10MP0004130_abnormal_muscle_cell2.95204348
11MP0005330_cardiomyopathy2.90538520
12MP0004036_abnormal_muscle_relaxation2.81085432
13MP0003806_abnormal_nucleotide_metabolis2.75295835
14MP0005058_abnormal_lysosome_morphology2.70139120
15MP0005670_abnormal_white_adipose2.57476203
16MP0000749_muscle_degeneration2.33613465
17MP0008875_abnormal_xenobiotic_pharmacok2.32726080
18MP0003252_abnormal_bile_duct2.31179498
19MP0010329_abnormal_lipoprotein_level2.27643655
20MP0005666_abnormal_adipose_tissue2.26841254
21MP0004087_abnormal_muscle_fiber2.21783668
22MP0009840_abnormal_foam_cell2.18079856
23MP0008775_abnormal_heart_ventricle2.12160674
24MP0002972_abnormal_cardiac_muscle2.07937565
25MP0010234_abnormal_vibrissa_follicle2.06214202
26MP0006036_abnormal_mitochondrial_physio1.96071483
27MP0010630_abnormal_cardiac_muscle1.95346722
28MP0005385_cardiovascular_system_phenoty1.93040398
29MP0001544_abnormal_cardiovascular_syste1.93040398
30MP0006138_congestive_heart_failure1.80902890
31MP0003705_abnormal_hypodermis_morpholog1.80804434
32* MP0005332_abnormal_amino_acid1.77969722
33MP0005620_abnormal_muscle_contractility1.77634511
34MP0003303_peritoneal_inflammation1.77530425
35MP0002877_abnormal_melanocyte_morpholog1.76640464
36MP0000750_abnormal_muscle_regeneration1.73448538
37MP0003195_calcinosis1.71783772
38MP0002269_muscular_atrophy1.70674910
39MP0005083_abnormal_biliary_tract1.68930593
40MP0003137_abnormal_impulse_conducting1.66743963
41MP0003191_abnormal_cellular_cholesterol1.65059498
42MP0004185_abnormal_adipocyte_glucose1.64444796
43* MP0002118_abnormal_lipid_homeostasis1.63076584
44MP0003221_abnormal_cardiomyocyte_apopto1.50923294
45MP0002106_abnormal_muscle_physiology1.49499069
46* MP0000609_abnormal_liver_physiology1.46378245
47MP0005375_adipose_tissue_phenotype1.45953337
48MP0001666_abnormal_nutrient_absorption1.44984199
49* MP0005319_abnormal_enzyme/_coenzyme1.44565150
50MP0002971_abnormal_brown_adipose1.43169872
51MP0004484_altered_response_of1.39419403
52MP0010352_gastrointestinal_tract_polyps1.34818264
53MP0008260_abnormal_autophagy1.34068094
54MP0003828_pulmonary_edema1.33338202
55MP0010368_abnormal_lymphatic_system1.33058447
56MP0005409_darkened_coat_color1.29939470
57MP0000747_muscle_weakness1.29800274
58MP0002396_abnormal_hematopoietic_system1.24979937
59MP0005584_abnormal_enzyme/coenzyme_acti1.20508090
60MP0004085_abnormal_heartbeat1.20242328
61MP0005369_muscle_phenotype1.18189006
62* MP0000759_abnormal_skeletal_muscle1.17882130
63MP0000858_altered_metastatic_potential1.16452080
64MP0002166_altered_tumor_susceptibility1.15700014
65MP0008438_abnormal_cutaneous_collagen1.12625141
66MP0005408_hypopigmentation1.12501229
67MP0005464_abnormal_platelet_physiology1.11584245
68MP0005451_abnormal_body_composition1.10478846
69MP0004264_abnormal_extraembryonic_tissu1.04848020
70* MP0009643_abnormal_urine_homeostasis1.04808827
71MP0004147_increased_porphyrin_level1.02445858
72MP0004233_abnormal_muscle_weight1.02430428
73MP0003453_abnormal_keratinocyte_physiol1.00447361
74MP0006035_abnormal_mitochondrial_morpho1.00431594
75MP0001545_abnormal_hematopoietic_system0.99945124
76MP0005397_hematopoietic_system_phenotyp0.99945124
77* MP0002078_abnormal_glucose_homeostasis0.97085447
78MP0002332_abnormal_exercise_endurance0.96596536
79MP0003172_abnormal_lysosome_physiology0.95365164
80MP0000604_amyloidosis0.94772121
81MP0001915_intracranial_hemorrhage0.94126483
82MP0001853_heart_inflammation0.93229914
83MP0002127_abnormal_cardiovascular_syste0.92483769
84MP0005334_abnormal_fat_pad0.91929441
85MP0002796_impaired_skin_barrier0.91882327
86MP0000343_altered_response_to0.90843010
87MP0005266_abnormal_metabolism0.90627167
88MP0004957_abnormal_blastocyst_morpholog0.88953253
89MP0003566_abnormal_cell_adhesion0.88655155
90MP0000003_abnormal_adipose_tissue0.88123308
91MP0003941_abnormal_skin_development0.87459176
92MP0003950_abnormal_plasma_membrane0.85862612
93MP0005501_abnormal_skin_physiology0.85715838
94MP0004510_myositis0.84675236
95MP0004145_abnormal_muscle_electrophysio0.84593343
96MP0004019_abnormal_vitamin_homeostasis0.84155302
97MP0003567_abnormal_fetal_cardiomyocyte0.83721789
98MP0005535_abnormal_body_temperature0.83364450
99MP0010155_abnormal_intestine_physiology0.82832042
100MP0005166_decreased_susceptibility_to0.81692243
101MP0005165_increased_susceptibility_to0.81549826
102MP0003183_abnormal_peptide_metabolism0.80314582
103MP0005275_abnormal_skin_tensile0.79772908
104MP0000230_abnormal_systemic_arterial0.79352366
105MP0003279_aneurysm0.79164680
106MP0003186_abnormal_redox_activity0.78757011
107MP0004043_abnormal_pH_regulation0.78650490
108MP0009115_abnormal_fat_cell0.78621258
109MP0005076_abnormal_cell_differentiation0.78270433
110MP0002138_abnormal_hepatobiliary_system0.78152024
111MP0004782_abnormal_surfactant_physiolog0.78134808
112* MP0000266_abnormal_heart_morphology0.78105272
113MP0002009_preneoplasia0.77947457
114MP0001730_embryonic_growth_arrest0.77895627
115MP0001727_abnormal_embryo_implantation0.77084905
116MP0002060_abnormal_skin_morphology0.76151398
117MP0003656_abnormal_erythrocyte_physiolo0.75178509
118MP0008007_abnormal_cellular_replicative0.72291145
119* MP0000598_abnormal_liver_morphology0.72137522
120MP0003329_amyloid_beta_deposits0.70578387
121MP0009672_abnormal_birth_weight0.70384517
122MP0002128_abnormal_blood_circulation0.69738355
123MP0002970_abnormal_white_adipose0.69523360
124MP0000013_abnormal_adipose_tissue0.69311585
125MP0001764_abnormal_homeostasis0.68572073
126MP0008961_abnormal_basal_metabolism0.66446954
127MP0009384_cardiac_valve_regurgitation0.63999078
128MP0001661_extended_life_span0.63910503
129MP0009763_increased_sensitivity_to0.63876279
130MP0001756_abnormal_urination0.62103311
131MP0004272_abnormal_basement_membrane0.60687294
132MP0003868_abnormal_feces_composition0.58803032
133MP0005448_abnormal_energy_balance0.58287212
134* MP0009642_abnormal_blood_homeostasis0.58029950
135MP0002108_abnormal_muscle_morphology0.56864186
136MP0003300_gastrointestinal_ulcer0.55345708
137MP0001879_abnormal_lymphatic_vessel0.55299399

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.00477355
2Ventricular tachycardia (HP:0004756)4.82212028
3* Sudden death (HP:0001699)4.70607540
4* Myoglobinuria (HP:0002913)4.40865290
5Exercise-induced myalgia (HP:0003738)4.30032807
6Right ventricular cardiomyopathy (HP:0011663)4.18402870
7Ketosis (HP:0001946)4.15305767
8Ketoacidosis (HP:0001993)4.13772031
9Hyperglycinuria (HP:0003108)4.09365878
10Exercise-induced muscle cramps (HP:0003710)4.02319509
11* Abnormality of fatty-acid metabolism (HP:0004359)3.96813477
12Dicarboxylic aciduria (HP:0003215)3.89768972
13Abnormality of dicarboxylic acid metabolism (HP:0010995)3.89768972
14* Hyperammonemia (HP:0001987)3.80298689
15Lipoatrophy (HP:0100578)3.77909173
16Nemaline bodies (HP:0003798)3.75434542
17Centrally nucleated skeletal muscle fibers (HP:0003687)3.70356091
18Calf muscle hypertrophy (HP:0008981)3.68337444
19Atrial fibrillation (HP:0005110)3.67511973
20Abnormality of glycine metabolism (HP:0010895)3.65378190
21Abnormality of serine family amino acid metabolism (HP:0010894)3.65378190
22Muscle fiber splitting (HP:0003555)3.63578484
23Xanthomatosis (HP:0000991)3.62013192
24Palpitations (HP:0001962)3.58084523
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.58009834
26Muscle fiber inclusion bodies (HP:0100299)3.57972258
27Hyporeflexia of lower limbs (HP:0002600)3.57794393
28Deep venous thrombosis (HP:0002625)3.57428247
29* Rhabdomyolysis (HP:0003201)3.43077549
30Intrahepatic cholestasis (HP:0001406)3.42455357
31Hypoalphalipoproteinemia (HP:0003233)3.39781551
32Primary atrial arrhythmia (HP:0001692)3.37497562
33Muscle hypertrophy of the lower extremities (HP:0008968)3.29686399
34Supraventricular tachycardia (HP:0004755)3.24648139
35Asymmetric septal hypertrophy (HP:0001670)3.21490020
36Syncope (HP:0001279)3.20461761
37Supraventricular arrhythmia (HP:0005115)3.20407147
38Hepatic necrosis (HP:0002605)3.14906841
39Increased connective tissue (HP:0009025)3.14753643
40* Dilated cardiomyopathy (HP:0001644)3.13542563
41Abnormality of aromatic amino acid family metabolism (HP:0004338)3.11703749
42Abnormality of glycolysis (HP:0004366)3.11256921
43Atrioventricular block (HP:0001678)3.09875884
44Generalized aminoaciduria (HP:0002909)3.08327041
45Bundle branch block (HP:0011710)3.07628211
46Abnormal gallbladder physiology (HP:0012438)3.06866063
47Cholecystitis (HP:0001082)3.06866063
48Hyperglycinemia (HP:0002154)3.05783378
49Distal lower limb muscle weakness (HP:0009053)3.03257633
50Hyperlipoproteinemia (HP:0010980)3.03254616
51Abnormality of the left ventricular outflow tract (HP:0011103)3.01520833
52Subaortic stenosis (HP:0001682)3.01520833
53Abnormality of the calf musculature (HP:0001430)3.00257850
54Increased serum pyruvate (HP:0003542)2.96512804
55Hypolipoproteinemia (HP:0010981)2.93366336
56Cerebral edema (HP:0002181)2.90496951
57Heart block (HP:0012722)2.88572720
58Ventricular arrhythmia (HP:0004308)2.81593927
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.79980474
60Type 1 muscle fiber predominance (HP:0003803)2.78008091
61Increased muscle lipid content (HP:0009058)2.76271835
62Systemic lupus erythematosus (HP:0002725)2.73565766
63Difficulty running (HP:0009046)2.72857909
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.72629680
65Abnormal atrioventricular conduction (HP:0005150)2.71935478
66Vertebral compression fractures (HP:0002953)2.66954269
67Metabolic acidosis (HP:0001942)2.66366433
68Hyperinsulinemic hypoglycemia (HP:0000825)2.63258132
69Polycythemia (HP:0001901)2.62824291
70Abnormality of skeletal muscle fiber size (HP:0012084)2.62267623
71Hypobetalipoproteinemia (HP:0003563)2.61437765
72Nausea (HP:0002018)2.59515737
73Complement deficiency (HP:0004431)2.52508416
74Epidermoid cyst (HP:0200040)2.50347405
75Abnormality of complement system (HP:0005339)2.50291895
76EMG: myopathic abnormalities (HP:0003458)2.50210371
77Conjunctival hamartoma (HP:0100780)2.49778650
78Prolonged QT interval (HP:0001657)2.49264709
79* Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.48135125
80Abnormality of glutamine family amino acid metabolism (HP:0010902)2.47019851
81Skin nodule (HP:0200036)2.46013401
82Lethargy (HP:0001254)2.45897374
83Prolonged partial thromboplastin time (HP:0003645)2.39920294
84Progressive muscle weakness (HP:0003323)2.38927532
85Myopathic facies (HP:0002058)2.37306188
86Proximal tubulopathy (HP:0000114)2.34547826
87Distal lower limb amyotrophy (HP:0008944)2.33517450
88Reticulocytosis (HP:0001923)2.32715311
89Hyperglycemia (HP:0003074)2.30201181
90Ragged-red muscle fibers (HP:0003200)2.30129564
91Abnormality of serum amino acid levels (HP:0003112)2.29229371
92Abnormality of glycolipid metabolism (HP:0010969)2.29063060
93Abnormality of liposaccharide metabolism (HP:0010968)2.29063060
94Abnormality of glycosphingolipid metabolism (HP:0004343)2.29063060
95Myocardial infarction (HP:0001658)2.27396508
96Increased variability in muscle fiber diameter (HP:0003557)2.24172555
97Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23936413
98Neck muscle weakness (HP:0000467)2.23741624
99Cholelithiasis (HP:0001081)2.23644174
100Muscle stiffness (HP:0003552)2.22965635
101Ventricular fibrillation (HP:0001663)2.22333467
102Renal cortical cysts (HP:0000803)2.21714635
103Acute encephalopathy (HP:0006846)2.19897283
104Fat malabsorption (HP:0002630)2.18984487
105Hypoglycemic seizures (HP:0002173)2.15811267
106Hepatocellular necrosis (HP:0001404)2.15365588
107Vomiting (HP:0002013)2.15039273
108Hemorrhage of the eye (HP:0011885)2.10010051
109Abnormal gallbladder morphology (HP:0012437)2.09801759
110Lymphangioma (HP:0100764)2.05245819
111Hypercholesterolemia (HP:0003124)2.04870809
112Abnormality of sulfur amino acid metabolism (HP:0004339)2.02167782
113Late onset (HP:0003584)2.01502745
114Abnormality of the common coagulation pathway (HP:0010990)2.00273032
115Abnormality of purine metabolism (HP:0004352)1.99404434
116Protrusio acetabuli (HP:0003179)1.97478820
117Abnormal mitochondria in muscle tissue (HP:0008316)1.97140994
118Osteolytic defects of the hand bones (HP:0009699)1.97104953
119Osteolytic defects of the phalanges of the hand (HP:0009771)1.97104953
120Myotonia (HP:0002486)1.96962282
121Steatorrhea (HP:0002570)1.96495130
122Neonatal death (HP:0003811)1.94786665
123Increased intramyocellular lipid droplets (HP:0012240)1.93403531
124Gout (HP:0001997)1.92741511
125Fatigue (HP:0012378)1.91991546
126Ileus (HP:0002595)1.91631647
127Hamartoma of the eye (HP:0010568)1.91367120
128* Lactic acidosis (HP:0003128)1.90820697
129Difficulty climbing stairs (HP:0003551)1.90699109
130Hyperbilirubinemia (HP:0002904)1.90350707
131Abnormal cartilage morphology (HP:0002763)1.89958138
132Multiple enchondromatosis (HP:0005701)1.89943657
133Glomerulonephritis (HP:0000099)1.88616812
134Hydroxyprolinuria (HP:0003080)1.88554033
135Mildly elevated creatine phosphokinase (HP:0008180)1.76882346
136Ulnar deviation of the wrist (HP:0003049)1.76842892
137Abnormality of the Achilles tendon (HP:0005109)1.76688880
138Vacuolated lymphocytes (HP:0001922)1.76356808
139Breech presentation (HP:0001623)1.74197429
140Premature rupture of membranes (HP:0001788)1.73888910
141Abnormality of the tricuspid valve (HP:0001702)1.73193618
142Flat acetabular roof (HP:0003180)1.71092801
143Foot dorsiflexor weakness (HP:0009027)1.70947658
144Abnormality of the gallbladder (HP:0005264)1.69996439
145Asymmetry of the thorax (HP:0001555)1.69834357
146Achilles tendon contracture (HP:0001771)1.69474606
147Back pain (HP:0003418)1.68312767
148Abnormality of the foot musculature (HP:0001436)1.66838274
149Abnormality of reticulocytes (HP:0004312)1.64211754
150Eczematoid dermatitis (HP:0000976)1.60803545
151Purpura (HP:0000979)1.60088502
152Abnormality of the intrinsic pathway (HP:0010989)1.60043629
153Neoplasm of head and neck (HP:0012288)1.59507339
154Esophageal neoplasm (HP:0100751)1.59507339
155Colitis (HP:0002583)1.59368281
156Esophageal varix (HP:0002040)1.59059868
157Dysostosis multiplex (HP:0000943)1.59013380
158Hypertriglyceridemia (HP:0002155)1.58382153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.60316179
2TTN4.24514619
3TRIB34.11866875
4PDK33.81258741
5PDK43.81258741
6PKN23.73767162
7LMTK23.38318695
8OBSCN2.63664285
9SCYL22.48978313
10PHKG12.44543225
11PHKG22.44543225
12MYLK2.38741906
13PRPF4B2.34068233
14SIK12.29448996
15EIF2AK12.28589070
16PDK22.27336594
17ERN11.96020667
18TIE11.92229420
19NEK11.91612665
20NME21.89601087
21DMPK1.89052846
22TAOK21.85843665
23SMG11.80635296
24FGFR41.73989192
25PIK3CA1.67020916
26INSRR1.63478842
27IRAK31.62375111
28FLT31.57362506
29EIF2AK31.51871184
30RIPK11.44132456
31PINK11.42671428
32KSR21.38752664
33MKNK21.37739781
34CAMK1D1.32585105
35STK241.32530363
36PBK1.27411780
37JAK31.27370053
38CDK121.24812204
39MKNK11.24767653
40PRKAA21.18791050
41PTK61.18471309
42RPS6KB21.17621598
43MAP3K71.15609479
44MAP3K11.12586281
45PAK41.10734232
46NEK91.07135694
47WNK41.07023546
48MAP3K21.06658452
49PDGFRA1.05622148
50STK38L1.05009670
51MAP2K31.03958260
52MAP3K101.03027038
53LATS11.02644557
54PRKD10.98152019
55MAP3K80.98040932
56PRKAA10.96978427
57EPHB10.95504854
58ILK0.93891958
59ZAP700.92468579
60TTK0.91360232
61KDR0.91286576
62PAK30.90703176
63TGFBR20.89827294
64TAOK10.89522780
65MST1R0.88815835
66RIPK40.83092311
67MAPK110.82004894
68MAP3K30.81668561
69MAP3K140.81087450
70TESK20.79039484
71ABL20.78247593
72TESK10.76383872
73CAMK1G0.76362786
74ICK0.74705663
75PIM20.74016041
76STK40.72980609
77MAPK120.71346708
78CLK10.69663753
79PIK3CG0.65951849
80MAPKAPK30.62278529
81JAK10.62263586
82ROCK10.61726562
83LRRK20.60881007
84PDPK10.59599490
85MTOR0.57433352
86GRK70.56549257
87TYK20.55904515
88CAMK2D0.55693602
89MAP3K50.55641394
90RAF10.54612368
91EEF2K0.54403016
92JAK20.54264180
93PRKACG0.54049484
94BMPR20.53821494
95PAK20.53338197
96MAP3K60.53026049
97FGFR30.50906006
98DDR20.50855786
99TRPM70.50572394
100MUSK0.50238607
101EPHA30.50207950
102PDK10.49047756
103CAMK40.48162049
104MAP4K10.47888042
105LATS20.47747250
106CDC42BPA0.47245135
107TBK10.46838876
108MET0.45218903
109YES10.45192843
110STK380.43133147
111MAP3K120.42977744
112MOS0.42383801
113PTK20.42216901
114RET0.40330058
115DAPK30.40256226
116SGK30.39956335
117ARAF0.39325813
118CDK40.38961229
119ALK0.38250388
120EPHB20.37544096
121EPHA20.37168984
122STK100.37053921
123FRK0.36128009
124FGFR20.35739997
125NTRK10.35598677
126PKN10.34859518
127PRKG20.31896860
128RPS6KC10.30701213
129RPS6KL10.30701213
130PRKACB0.29882516
131WNK10.29037345
132DYRK1B0.28784969
133PRKCH0.28436876
134MAP3K110.28096991
135AKT20.27934439
136ZAK0.27397259
137ERBB40.26739605
138MAP2K10.26666334
139RPS6KA10.26638418
140RPS6KA60.25736446
141FER0.25192792
142GSK3A0.24457693
143CDK60.24347881
144PTK2B0.23479010
145PDGFRB0.22901908

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.23148989
2* Fatty acid degradation_Homo sapiens_hsa000713.73760590
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.64075382
4* Propanoate metabolism_Homo sapiens_hsa006403.54058253
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.47820950
6* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.23234868
7* Fatty acid metabolism_Homo sapiens_hsa012122.90777085
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.89129627
9Other glycan degradation_Homo sapiens_hsa005112.57987466
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.56076938
11PPAR signaling pathway_Homo sapiens_hsa033202.43670702
12Nitrogen metabolism_Homo sapiens_hsa009102.42471881
13* Carbon metabolism_Homo sapiens_hsa012002.34030375
14Pyruvate metabolism_Homo sapiens_hsa006202.30303645
15Arginine biosynthesis_Homo sapiens_hsa002202.24068607
16* Tryptophan metabolism_Homo sapiens_hsa003802.17462352
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00692692
18* Butanoate metabolism_Homo sapiens_hsa006501.96891714
19Peroxisome_Homo sapiens_hsa041461.80765440
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61728095
21Renin-angiotensin system_Homo sapiens_hsa046141.55206870
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54489161
23* Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49771123
24Biosynthesis of amino acids_Homo sapiens_hsa012301.49080702
25Complement and coagulation cascades_Homo sapiens_hsa046101.45773404
26Starch and sucrose metabolism_Homo sapiens_hsa005001.45418311
27* beta-Alanine metabolism_Homo sapiens_hsa004101.45282376
28* Fatty acid elongation_Homo sapiens_hsa000621.37699280
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35493191
30Fatty acid biosynthesis_Homo sapiens_hsa000611.32239135
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29819478
32Cardiac muscle contraction_Homo sapiens_hsa042601.28086284
33Fat digestion and absorption_Homo sapiens_hsa049751.25947706
34Phenylalanine metabolism_Homo sapiens_hsa003601.23647487
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21661073
36Caffeine metabolism_Homo sapiens_hsa002321.19603719
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18304611
38Dilated cardiomyopathy_Homo sapiens_hsa054141.16538581
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16199684
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14327544
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12513525
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.12204955
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12154895
44Bile secretion_Homo sapiens_hsa049761.06424345
45Selenocompound metabolism_Homo sapiens_hsa004501.06090706
46* Lysine degradation_Homo sapiens_hsa003101.04157704
47Tyrosine metabolism_Homo sapiens_hsa003501.01445876
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99640054
49Parkinsons disease_Homo sapiens_hsa050120.96215438
50Chemical carcinogenesis_Homo sapiens_hsa052040.95590336
51Histidine metabolism_Homo sapiens_hsa003400.95236262
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93570221
53Sulfur metabolism_Homo sapiens_hsa009200.93268116
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92885877
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.92713670
56Insulin resistance_Homo sapiens_hsa049310.92138167
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.90839616
58Arginine and proline metabolism_Homo sapiens_hsa003300.89965205
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87830887
60Thyroid cancer_Homo sapiens_hsa052160.87216736
61ABC transporters_Homo sapiens_hsa020100.86859431
62Glycerolipid metabolism_Homo sapiens_hsa005610.86478873
63Oxidative phosphorylation_Homo sapiens_hsa001900.85293078
64Staphylococcus aureus infection_Homo sapiens_hsa051500.80244983
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78974419
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78819258
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.78222817
68Retinol metabolism_Homo sapiens_hsa008300.77842982
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.76080357
70Lysosome_Homo sapiens_hsa041420.74866698
71Glucagon signaling pathway_Homo sapiens_hsa049220.72006087
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71822375
73Pentose phosphate pathway_Homo sapiens_hsa000300.66992821
74AMPK signaling pathway_Homo sapiens_hsa041520.65871328
75Acute myeloid leukemia_Homo sapiens_hsa052210.65364497
76Alzheimers disease_Homo sapiens_hsa050100.63071673
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61519692
78Galactose metabolism_Homo sapiens_hsa000520.59874115
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59748743
80Chronic myeloid leukemia_Homo sapiens_hsa052200.58229822
81Insulin signaling pathway_Homo sapiens_hsa049100.54129435
82Sulfur relay system_Homo sapiens_hsa041220.53308775
83Folate biosynthesis_Homo sapiens_hsa007900.52214627
84Fructose and mannose metabolism_Homo sapiens_hsa000510.51472809
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49156880
86Leishmaniasis_Homo sapiens_hsa051400.44231510
87Huntingtons disease_Homo sapiens_hsa050160.43504567
88* Metabolic pathways_Homo sapiens_hsa011000.43430069
89Viral myocarditis_Homo sapiens_hsa054160.43321355
90Pancreatic cancer_Homo sapiens_hsa052120.42654011
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42620097
92Mineral absorption_Homo sapiens_hsa049780.41744517
93Non-small cell lung cancer_Homo sapiens_hsa052230.40894922
94Glutathione metabolism_Homo sapiens_hsa004800.40867342
95Bladder cancer_Homo sapiens_hsa052190.39028152
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.36947342
97Vitamin digestion and absorption_Homo sapiens_hsa049770.36119805
98Asthma_Homo sapiens_hsa053100.35171860
99Protein digestion and absorption_Homo sapiens_hsa049740.31981704
100Toxoplasmosis_Homo sapiens_hsa051450.31709820
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31283895
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30917375
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30752588
104N-Glycan biosynthesis_Homo sapiens_hsa005100.30725536
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.30434049
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28972738
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.28662255
108Antigen processing and presentation_Homo sapiens_hsa046120.27392507
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.27116241
110Vitamin B6 metabolism_Homo sapiens_hsa007500.26206338
111Pertussis_Homo sapiens_hsa051330.24368831
112Sphingolipid metabolism_Homo sapiens_hsa006000.22568496
113Influenza A_Homo sapiens_hsa051640.22523820
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20656977
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20303231
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18659911
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15356094
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.12260765
119Focal adhesion_Homo sapiens_hsa045100.11657183
120Type II diabetes mellitus_Homo sapiens_hsa049300.09920365
121ECM-receptor interaction_Homo sapiens_hsa045120.09134547
122HIF-1 signaling pathway_Homo sapiens_hsa040660.08568651
123One carbon pool by folate_Homo sapiens_hsa006700.07471915
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.06683660
125Amoebiasis_Homo sapiens_hsa051460.04237565
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.01523480
127Linoleic acid metabolism_Homo sapiens_hsa005910.01511177
128Steroid biosynthesis_Homo sapiens_hsa001000.01393749
129Prion diseases_Homo sapiens_hsa050200.00902245

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