H6PD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.63270566
2L-phenylalanine catabolic process (GO:0006559)6.63270566
3L-phenylalanine metabolic process (GO:0006558)6.38124841
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.38124841
5aromatic amino acid family catabolic process (GO:0009074)5.92538085
6complement activation, alternative pathway (GO:0006957)5.58957790
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.52573976
8alpha-linolenic acid metabolic process (GO:0036109)5.47628138
9tryptophan catabolic process (GO:0006569)5.34779408
10indole-containing compound catabolic process (GO:0042436)5.34779408
11indolalkylamine catabolic process (GO:0046218)5.34779408
12glyoxylate metabolic process (GO:0046487)5.33586965
13regulation of protein activation cascade (GO:2000257)5.31677719
14kynurenine metabolic process (GO:0070189)5.30071175
15negative regulation of fibrinolysis (GO:0051918)5.26635734
16bile acid biosynthetic process (GO:0006699)5.24607351
17cysteine metabolic process (GO:0006534)5.21269635
18sulfur amino acid catabolic process (GO:0000098)5.13676749
19urea cycle (GO:0000050)5.07138467
20urea metabolic process (GO:0019627)5.07138467
21regulation of complement activation (GO:0030449)5.05824155
22tryptophan metabolic process (GO:0006568)5.04834633
23protein carboxylation (GO:0018214)5.04383354
24peptidyl-glutamic acid carboxylation (GO:0017187)5.04383354
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.96995995
26regulation of fibrinolysis (GO:0051917)4.92112901
27high-density lipoprotein particle remodeling (GO:0034375)4.72584735
28nitrogen cycle metabolic process (GO:0071941)4.65976577
29lysine metabolic process (GO:0006553)4.65798906
30lysine catabolic process (GO:0006554)4.65798906
31homocysteine metabolic process (GO:0050667)4.61031709
32regulation of triglyceride catabolic process (GO:0010896)4.57245668
33serine family amino acid catabolic process (GO:0009071)4.54884412
34bile acid metabolic process (GO:0008206)4.51374930
35amino-acid betaine metabolic process (GO:0006577)4.40304861
36triglyceride homeostasis (GO:0070328)4.38110759
37acylglycerol homeostasis (GO:0055090)4.38110759
38plasma lipoprotein particle clearance (GO:0034381)4.37451181
39reverse cholesterol transport (GO:0043691)4.29059293
40aromatic amino acid family metabolic process (GO:0009072)4.25424865
41tyrosine metabolic process (GO:0006570)4.16550104
42protein-lipid complex remodeling (GO:0034368)4.13877664
43macromolecular complex remodeling (GO:0034367)4.13877664
44plasma lipoprotein particle remodeling (GO:0034369)4.13877664
45alpha-amino acid catabolic process (GO:1901606)4.12581557
46exogenous drug catabolic process (GO:0042738)4.12321857
47regulation of cholesterol esterification (GO:0010872)4.03817073
48ethanol oxidation (GO:0006069)3.98067627
49phospholipid efflux (GO:0033700)3.97410888
50positive regulation of fatty acid beta-oxidation (GO:0032000)3.87892200
51negative regulation of cholesterol transport (GO:0032375)3.86637806
52negative regulation of sterol transport (GO:0032372)3.86637806
53bile acid and bile salt transport (GO:0015721)3.86554228
54cellular amino acid catabolic process (GO:0009063)3.85656322
55phospholipid homeostasis (GO:0055091)3.82914412
56cellular modified amino acid catabolic process (GO:0042219)3.81893923
57coenzyme catabolic process (GO:0009109)3.81867718
58cellular ketone body metabolic process (GO:0046950)3.81033620
59fibrinolysis (GO:0042730)3.79316160
60acetyl-CoA metabolic process (GO:0006084)3.77610505
61valine metabolic process (GO:0006573)3.76979448
62regulation of cholesterol homeostasis (GO:2000188)3.76817238
63glycine metabolic process (GO:0006544)3.76480256
64positive regulation of lipid catabolic process (GO:0050996)3.76422713
65fatty acid beta-oxidation (GO:0006635)3.75912970
66serine family amino acid metabolic process (GO:0009069)3.75487359
67glutamate metabolic process (GO:0006536)3.72518892
68indolalkylamine metabolic process (GO:0006586)3.71860461
69cellular glucuronidation (GO:0052695)3.70680548
70complement activation (GO:0006956)3.70352442
71fatty acid oxidation (GO:0019395)3.69846812
72complement activation, classical pathway (GO:0006958)3.66581226
73benzene-containing compound metabolic process (GO:0042537)3.65455517
74cholesterol efflux (GO:0033344)3.65446794
752-oxoglutarate metabolic process (GO:0006103)3.64777706
76lipid oxidation (GO:0034440)3.62322765
77cytolysis (GO:0019835)3.61338393
78cellular biogenic amine catabolic process (GO:0042402)3.57230514
79amine catabolic process (GO:0009310)3.57230514
80dicarboxylic acid biosynthetic process (GO:0043650)3.54910687
81protein activation cascade (GO:0072376)3.53982502
82imidazole-containing compound metabolic process (GO:0052803)3.53633155
83plasma lipoprotein particle assembly (GO:0034377)3.53396423
84short-chain fatty acid metabolic process (GO:0046459)3.53355476
85fatty acid catabolic process (GO:0009062)3.52530639
86negative regulation of lipase activity (GO:0060192)3.51594063
87carboxylic acid catabolic process (GO:0046395)3.51591358
88organic acid catabolic process (GO:0016054)3.51591358
89drug catabolic process (GO:0042737)3.49533897
90cholesterol homeostasis (GO:0042632)3.49446848
91monocarboxylic acid catabolic process (GO:0072329)3.48499776
92low-density lipoprotein particle clearance (GO:0034383)3.48129909
93epoxygenase P450 pathway (GO:0019373)3.46473838
94sterol homeostasis (GO:0055092)3.45451593
95aldehyde catabolic process (GO:0046185)3.43977755
96negative regulation of protein activation cascade (GO:2000258)3.42911906
97positive regulation of triglyceride lipase activity (GO:0061365)3.41627288
98positive regulation of lipoprotein lipase activity (GO:0051006)3.41627288
99opsonization (GO:0008228)3.41586437
100serine family amino acid biosynthetic process (GO:0009070)3.41122698
101drug transmembrane transport (GO:0006855)3.40779570
102regulation of apoptotic cell clearance (GO:2000425)3.39283222
103omega-hydroxylase P450 pathway (GO:0097267)3.36589617
104regulation of plasminogen activation (GO:0010755)3.10623990
105positive regulation of extracellular matrix organization (GO:1903055)3.06349428
106negative regulation of complement activation (GO:0045916)2.96280322
107negative regulation of fatty acid transport (GO:2000192)2.90954158
108acute-phase response (GO:0006953)2.85798580
109ethanol metabolic process (GO:0006067)2.82327804
110negative regulation of blood coagulation (GO:0030195)2.81329836
111negative regulation of hemostasis (GO:1900047)2.81329836
112regulation of humoral immune response (GO:0002920)2.79580074
113mannose metabolic process (GO:0006013)2.77533078
114blood coagulation, intrinsic pathway (GO:0007597)2.66016196
115negative regulation of humoral immune response (GO:0002921)2.60503503
116negative regulation of coagulation (GO:0050819)2.59817178
117positive regulation of blood coagulation (GO:0030194)2.53585206
118positive regulation of hemostasis (GO:1900048)2.53585206
119negative regulation of wound healing (GO:0061045)2.50808531
120virion attachment to host cell (GO:0019062)2.47730488
121adhesion of symbiont to host cell (GO:0044650)2.47730488
122response to mercury ion (GO:0046689)2.46918316
123regulation of extracellular matrix disassembly (GO:0010715)2.46075338
124adhesion of symbiont to host (GO:0044406)2.45765892
125drug metabolic process (GO:0017144)2.45072702
126basement membrane organization (GO:0071711)2.42392723
127positive regulation of coagulation (GO:0050820)2.39524706
128positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.38137188
129regulation of extracellular matrix organization (GO:1903053)2.35624124
130negative regulation of lipid transport (GO:0032369)2.34220220
131hormone catabolic process (GO:0042447)2.32441079
132detection of molecule of bacterial origin (GO:0032490)2.30783202
133insulin-like growth factor receptor signaling pathway (GO:0048009)2.27910234
134glucuronate metabolic process (GO:0019585)2.26197334
135uronic acid metabolic process (GO:0006063)2.26197334
136barbed-end actin filament capping (GO:0051016)2.23796252
137regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.23369230
138macroautophagy (GO:0016236)2.22854033
139skin morphogenesis (GO:0043589)2.22299425
140positive regulation of endothelial cell apoptotic process (GO:2000353)2.18598082
141positive regulation of cholesterol efflux (GO:0010875)2.17949554
142regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.17732415
143lipoprotein metabolic process (GO:0042157)2.17563669
144cell migration involved in heart development (GO:0060973)2.16905079
145apoptotic cell clearance (GO:0043277)2.16482283
146fat-soluble vitamin biosynthetic process (GO:0042362)2.14025446
147growth hormone receptor signaling pathway (GO:0060396)2.13119326
148vascular endothelial growth factor signaling pathway (GO:0038084)2.12531704
149detection of external biotic stimulus (GO:0098581)2.12390372
150regulation of membrane protein ectodomain proteolysis (GO:0051043)2.11118502
151positive regulation of cholesterol transport (GO:0032376)2.10095979
152positive regulation of sterol transport (GO:0032373)2.10095979
153endodermal cell differentiation (GO:0035987)2.09876840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.51064924
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.51724264
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.32414768
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.95894096
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.74290888
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.68403907
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.21710297
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.87382106
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.28220299
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.82612560
11* CLOCK_20551151_ChIP-Seq_293T_Human2.53490554
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5614379
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95635416
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86222726
15GATA1_22025678_ChIP-Seq_K562_Human1.85350079
16* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83664975
17BP1_19119308_ChIP-ChIP_Hs578T_Human1.83087614
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73301303
19* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70815576
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.65762723
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65571831
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49031360
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40834954
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39167232
25* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38407517
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.36759054
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32711626
28NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30109588
29* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29965332
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26611216
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26512120
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.24878659
33TCF7_22412390_ChIP-Seq_EML_Mouse1.24814436
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.24409224
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24036253
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.23790448
37* IRF8_27001747_Chip-Seq_BMDM_Mouse1.21862943
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18792760
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15971119
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.15827191
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15682909
42VDR_24787735_ChIP-Seq_THP-1_Human1.15349479
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14693622
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14372607
45KDM2B_26808549_Chip-Seq_DND41_Human1.14012287
46DROSHA_22980978_ChIP-Seq_HELA_Human1.12796500
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11602756
48* RUNX_20019798_ChIP-Seq_JUKART_Human1.10873946
49VDR_24763502_ChIP-Seq_THP-1_Human1.10284701
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.09601188
51* KDM2B_26808549_Chip-Seq_K562_Human1.09022552
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08621391
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08315660
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06786886
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05923822
56* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05574106
57VDR_21846776_ChIP-Seq_THP-1_Human1.04507271
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02779611
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01050094
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00790747
61RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00174897
62* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00084608
63ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99131324
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98837710
65ZNF263_19887448_ChIP-Seq_K562_Human0.98581662
66SPI1_23127762_ChIP-Seq_K562_Human0.98503749
67* GATA4_25053715_ChIP-Seq_YYC3_Human0.98237792
68FOXO3_23340844_ChIP-Seq_DLD1_Human0.97814539
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97565056
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97497356
71PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97088385
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97032846
73* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95716321
74STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95432755
75SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93869717
76SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90988421
77* KDM2B_26808549_Chip-Seq_JURKAT_Human0.88271080
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87620037
79HTT_18923047_ChIP-ChIP_STHdh_Human0.87480120
80CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87182318
81* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86866888
82DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86525966
83RUNX1_27514584_Chip-Seq_MCF-7_Human0.85845948
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85709288
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85469932
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85394308
87* LXR_22292898_ChIP-Seq_THP-1_Human0.84582176
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83099104
89* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82765943
90* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82542957
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82268622
92NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82268622
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82253814
94ESR1_20079471_ChIP-ChIP_T-47D_Human0.82067677
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81723187
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.79936635
97* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.76698885
98* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76407459
99TP63_17297297_ChIP-ChIP_HaCaT_Human0.75524793
100CDX2_20551321_ChIP-Seq_CACO-2_Human0.75073543
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73626393
102TBX20_22080862_ChIP-Seq_HEART_Mouse0.72635327
103TBX20_22328084_ChIP-Seq_HEART_Mouse0.72635327
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70382836
105GATA1_19941826_ChIP-Seq_K562_Human0.70312079
106RACK7_27058665_Chip-Seq_MCF-7_Human0.69504538
107SOX2_20726797_ChIP-Seq_SW620_Human0.69328339
108* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69315794
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.69301335
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68174024
111* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.66747675
112GATA2_19941826_ChIP-Seq_K562_Human0.65645202
113BRD4_27068464_Chip-Seq_AML-cells_Mouse0.65177014
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.63308680
115* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.63112433
116* GATA6_25053715_ChIP-Seq_YYC3_Human0.63002847
117RARA_24833708_ChIP-Seq_LIVER_Mouse0.62493682
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62461057
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.61998310
120AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61482512
121* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.61273683
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60130976
123EGR1_19032775_ChIP-ChIP_M12_Human0.59347279
124* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58118995
125CEBPB_22108803_ChIP-Seq_LS180_Human0.57996165
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.57137362
127GATA3_24758297_ChIP-Seq_MCF-7_Human0.56104714
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.55563645
129* ELK3_25401928_ChIP-Seq_HUVEC_Human0.54608663
130SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.54560349
131RARB_24833708_ChIP-Seq_LIVER_Mouse0.53306709
132HIF1A_21447827_ChIP-Seq_MCF-7_Human0.53211409
133RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.52962465
134* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.52461834
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52333588
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.52171605
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.51351680
138CJUN_26792858_Chip-Seq_BT549_Human0.51132089
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.49898546
140P63_26484246_Chip-Seq_KERATINOCYTES_Human0.49813819
141ATF3_27146783_Chip-Seq_COLON_Human0.49756089
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.49227718
143MYB_21317192_ChIP-Seq_ERMYB_Mouse0.48763241
144GATA1_19941827_ChIP-Seq_MEL_Mouse0.48523647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.26842686
2MP0005360_urolithiasis6.72108797
3MP0005365_abnormal_bile_salt5.52803300
4MP0005085_abnormal_gallbladder_physiolo5.42336264
5MP0008875_abnormal_xenobiotic_pharmacok4.41625285
6MP0003252_abnormal_bile_duct3.71117446
7MP0010329_abnormal_lipoprotein_level3.49755214
8MP0003806_abnormal_nucleotide_metabolis3.40086364
9MP0009840_abnormal_foam_cell2.92969830
10MP0003191_abnormal_cellular_cholesterol2.79890508
11MP0005083_abnormal_biliary_tract2.70728903
12MP0005332_abnormal_amino_acid2.62616270
13MP0003279_aneurysm2.49539584
14MP0003195_calcinosis2.41188103
15MP0001666_abnormal_nutrient_absorption2.30364023
16MP0005503_abnormal_tendon_morphology2.21381474
17MP0000751_myopathy2.20841822
18MP0000609_abnormal_liver_physiology2.15931990
19MP0002138_abnormal_hepatobiliary_system2.13812392
20MP0002118_abnormal_lipid_homeostasis2.11969374
21MP0004019_abnormal_vitamin_homeostasis2.05595460
22MP0003705_abnormal_hypodermis_morpholog2.01031305
23MP0005670_abnormal_white_adipose1.98668834
24MP0005319_abnormal_enzyme/_coenzyme1.80484222
25MP0003091_abnormal_cell_migration1.58025083
26MP0008438_abnormal_cutaneous_collagen1.57326426
27MP0009643_abnormal_urine_homeostasis1.51846967
28MP0003868_abnormal_feces_composition1.47351088
29* MP0005584_abnormal_enzyme/coenzyme_acti1.44031192
30MP0005257_abnormal_intraocular_pressure1.43119456
31MP0004130_abnormal_muscle_cell1.40895117
32MP0002933_joint_inflammation1.40096158
33MP0000767_abnormal_smooth_muscle1.38944183
34MP0001764_abnormal_homeostasis1.37943898
35MP0003303_peritoneal_inflammation1.35734456
36MP0003186_abnormal_redox_activity1.34018989
37MP0002998_abnormal_bone_remodeling1.32900263
38MP0004510_myositis1.29490720
39MP0005666_abnormal_adipose_tissue1.28313694
40MP0010368_abnormal_lymphatic_system1.28229914
41MP0005409_darkened_coat_color1.21825517
42MP0003011_delayed_dark_adaptation1.21309155
43MP0000598_abnormal_liver_morphology1.19953864
44MP0004858_abnormal_nervous_system1.18242433
45MP0002254_reproductive_system_inflammat1.17138453
46MP0002108_abnormal_muscle_morphology1.16368555
47MP0003045_fibrosis1.16131302
48MP0000685_abnormal_immune_system1.16066534
49MP0003828_pulmonary_edema1.15934676
50MP0003172_abnormal_lysosome_physiology1.12002509
51MP0002971_abnormal_brown_adipose1.10011574
52MP0009764_decreased_sensitivity_to1.09688342
53MP0006054_spinal_hemorrhage1.09211473
54MP0002896_abnormal_bone_mineralization1.05564194
55MP0000604_amyloidosis1.05302705
56MP0009763_increased_sensitivity_to1.03485908
57MP0003656_abnormal_erythrocyte_physiolo1.02332241
58MP0002419_abnormal_innate_immunity1.02287278
59MP0005647_abnormal_sex_gland1.02224866
60MP0005451_abnormal_body_composition1.01447616
61MP0005636_abnormal_mineral_homeostasis0.99039137
62MP0004036_abnormal_muscle_relaxation0.96707006
63MP0005334_abnormal_fat_pad0.95643644
64MP0005387_immune_system_phenotype0.95193979
65MP0001790_abnormal_immune_system0.95193979
66MP0004947_skin_inflammation0.94763802
67MP0005595_abnormal_vascular_smooth0.94582456
68MP0004087_abnormal_muscle_fiber0.94147714
69MP0002876_abnormal_thyroid_physiology0.93547476
70MP0001661_extended_life_span0.93483483
71MP0001756_abnormal_urination0.93295271
72MP0006138_congestive_heart_failure0.93024668
73MP0009697_abnormal_copulation0.92946104
74MP0008469_abnormal_protein_level0.92672816
75MP0005390_skeleton_phenotype0.91881950
76MP0008004_abnormal_stomach_pH0.91527658
77MP0002837_dystrophic_cardiac_calcinosis0.90106110
78MP0000749_muscle_degeneration0.89437914
79MP0003724_increased_susceptibility_to0.89361214
80MP0000733_abnormal_muscle_development0.88781895
81MP0005275_abnormal_skin_tensile0.88609145
82MP0000759_abnormal_skeletal_muscle0.87401561
83MP0009780_abnormal_chondrocyte_physiolo0.87100314
84MP0004185_abnormal_adipocyte_glucose0.86856813
85MP0005025_abnormal_response_to0.86184956
86* MP0009642_abnormal_blood_homeostasis0.84010203
87MP0000747_muscle_weakness0.83578770
88MP0009785_altered_susceptibility_to0.83016882
89MP0002078_abnormal_glucose_homeostasis0.82908207
90MP0000013_abnormal_adipose_tissue0.82186847
91MP0005220_abnormal_exocrine_pancreas0.82141196
92MP0005058_abnormal_lysosome_morphology0.82065865
93MP0005076_abnormal_cell_differentiation0.81789511
94MP0003950_abnormal_plasma_membrane0.81737308
95MP0003300_gastrointestinal_ulcer0.81567124
96MP0005508_abnormal_skeleton_morphology0.80935172
97MP0001851_eye_inflammation0.80637706
98MP0000858_altered_metastatic_potential0.80583672
99MP0001542_abnormal_bone_strength0.80384093
100MP0005330_cardiomyopathy0.78284443
101MP0009384_cardiac_valve_regurgitation0.77968139
102MP0001849_ear_inflammation0.77752208
103MP0005375_adipose_tissue_phenotype0.77733960
104MP0001915_intracranial_hemorrhage0.77222664
105MP0006082_CNS_inflammation0.76953164
106MP0009115_abnormal_fat_cell0.76887292
107MP0002136_abnormal_kidney_physiology0.76726897
108MP0003453_abnormal_keratinocyte_physiol0.76703640
109MP0010155_abnormal_intestine_physiology0.75297961
110MP0002332_abnormal_exercise_endurance0.75176845
111MP0005084_abnormal_gallbladder_morpholo0.74105354
112MP0002106_abnormal_muscle_physiology0.73681334
113MP0006036_abnormal_mitochondrial_physio0.71643469
114MP0005535_abnormal_body_temperature0.71167257
115MP0005376_homeostasis/metabolism_phenot0.70825563
116MP0004782_abnormal_surfactant_physiolog0.69548365
117MP0003436_decreased_susceptibility_to0.69360974
118MP0003690_abnormal_glial_cell0.67451213
119MP0005408_hypopigmentation0.65073660
120MP0002060_abnormal_skin_morphology0.65029476
121MP0002168_other_aberrant_phenotype0.64285766
122MP0002928_abnormal_bile_duct0.63444577
123MP0009765_abnormal_xenobiotic_induced0.63176997
124MP0005464_abnormal_platelet_physiology0.62636846
125MP0005023_abnormal_wound_healing0.61723333
126MP0005448_abnormal_energy_balance0.60618144
127MP0002970_abnormal_white_adipose0.58950996
128MP0009053_abnormal_anal_canal0.57170240
129MP0000249_abnormal_blood_vessel0.55825185
130MP0003566_abnormal_cell_adhesion0.54356220
131MP0002796_impaired_skin_barrier0.54177228
132MP0002295_abnormal_pulmonary_circulatio0.53899003
133MP0004272_abnormal_basement_membrane0.53321648
134MP0005164_abnormal_response_to0.53278502
135MP0010234_abnormal_vibrissa_follicle0.52123757
136MP0001958_emphysema0.50820196
137MP0003329_amyloid_beta_deposits0.50059105
138MP0001881_abnormal_mammary_gland0.48462619
139MP0005395_other_phenotype0.48057237
140MP0003075_altered_response_to0.47340498
141MP0000230_abnormal_systemic_arterial0.46428355
142MP0005266_abnormal_metabolism0.46291165
143MP0003959_abnormal_lean_body0.45751880
144MP0004883_abnormal_blood_vessel0.45695372
145MP0005166_decreased_susceptibility_to0.45691569
146MP0002135_abnormal_kidney_morphology0.45497900
147MP0001243_abnormal_dermal_layer0.43080796
148MP0005167_abnormal_blood-brain_barrier0.42383336
149MP0001765_abnormal_ion_homeostasis0.42275545
150MP0001533_abnormal_skeleton_physiology0.40350393
151MP0001845_abnormal_inflammatory_respons0.40097413

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.83082932
2Intrahepatic cholestasis (HP:0001406)6.35651196
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.15991836
4Xanthomatosis (HP:0000991)5.87658052
5Complement deficiency (HP:0004431)5.86571289
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.68399297
7Prolonged partial thromboplastin time (HP:0003645)5.44835984
8Hypobetalipoproteinemia (HP:0003563)5.20651415
9Hyperlipoproteinemia (HP:0010980)4.93176797
10Protrusio acetabuli (HP:0003179)4.39098392
11Abnormality of complement system (HP:0005339)4.35659906
12Abnormality of the common coagulation pathway (HP:0010990)4.31459898
13Joint hemorrhage (HP:0005261)4.29855879
14Hyperammonemia (HP:0001987)4.29185755
15Hypolipoproteinemia (HP:0010981)4.26790065
16Epidermoid cyst (HP:0200040)4.18543431
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12929059
18Ketosis (HP:0001946)4.12134169
19Hyperglycinuria (HP:0003108)4.08991967
20Hypoalphalipoproteinemia (HP:0003233)4.04842677
21Hyperglycinemia (HP:0002154)3.99601351
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.99409265
23Abnormality of serine family amino acid metabolism (HP:0010894)3.89588735
24Abnormality of glycine metabolism (HP:0010895)3.89588735
25Hypoglycemic coma (HP:0001325)3.85915258
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.71261094
27Type 1 muscle fiber predominance (HP:0003803)3.66257927
28Premature rupture of membranes (HP:0001788)3.62245669
29Abnormality of the intrinsic pathway (HP:0010989)3.57141023
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.56923535
31Fat malabsorption (HP:0002630)3.56139957
32Abnormality of fatty-acid metabolism (HP:0004359)3.44473451
33Abnormality of methionine metabolism (HP:0010901)3.38792772
34Aortic aneurysm (HP:0004942)3.36214306
35Hypercholesterolemia (HP:0003124)3.34339642
36Systemic lupus erythematosus (HP:0002725)3.34093980
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26882882
38Aortic dissection (HP:0002647)3.25755607
39Myocardial infarction (HP:0001658)3.21924876
40Ketoacidosis (HP:0001993)3.10723269
41Conjugated hyperbilirubinemia (HP:0002908)3.05624970
42Abnormality of purine metabolism (HP:0004352)2.97515616
43Abnormality of nucleobase metabolism (HP:0010932)2.95474641
44Vascular tortuosity (HP:0004948)2.94111139
45Skin nodule (HP:0200036)2.92561068
46Abnormality of pyrimidine metabolism (HP:0004353)2.91392692
47Increased connective tissue (HP:0009025)2.90466417
48Cerebral aneurysm (HP:0004944)2.88087713
49Increased variability in muscle fiber diameter (HP:0003557)2.86763798
50Hepatocellular carcinoma (HP:0001402)2.85165782
51Hyperbilirubinemia (HP:0002904)2.83881402
52Gout (HP:0001997)2.83400859
53Spontaneous abortion (HP:0005268)2.78958036
54Arterial tortuosity (HP:0005116)2.73772627
55Delayed CNS myelination (HP:0002188)2.67986026
56Glomerulonephritis (HP:0000099)2.65354041
57Abnormality of serum amino acid levels (HP:0003112)2.64547281
58Cervical subluxation (HP:0003308)2.62032551
59Steatorrhea (HP:0002570)2.61427720
60Asymmetric septal hypertrophy (HP:0001670)2.61345789
61Esophageal varix (HP:0002040)2.60700221
62Abnormality of skeletal muscle fiber size (HP:0012084)2.59773999
63Metabolic acidosis (HP:0001942)2.52070625
64Dicarboxylic aciduria (HP:0003215)2.51540980
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51540980
66Aneurysm (HP:0002617)2.51240777
67Vascular calcification (HP:0004934)2.50978438
68Spastic diplegia (HP:0001264)2.47333831
69Exercise-induced myalgia (HP:0003738)2.47179370
70Recurrent gram-negative bacterial infections (HP:0005420)2.46434328
71Urinary glycosaminoglycan excretion (HP:0003541)2.43414598
72Mucopolysacchariduria (HP:0008155)2.43414598
73Mitral stenosis (HP:0001718)2.42466148
74Vertebral compression fractures (HP:0002953)2.41811099
75Cardiovascular calcification (HP:0011915)2.40742668
76Spinal rigidity (HP:0003306)2.39240408
77Abnormality of proline metabolism (HP:0010907)2.38346337
78Hydroxyprolinuria (HP:0003080)2.38346337
79Hemorrhage of the eye (HP:0011885)2.37452215
80Amyloidosis (HP:0011034)2.37397321
81Dilatation of the ascending aorta (HP:0005111)2.35483000
82Mildly elevated creatine phosphokinase (HP:0008180)2.34812883
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.32055397
84Abnormality of polysaccharide metabolism (HP:0011012)2.32055397
85Abnormality of glycosaminoglycan metabolism (HP:0004371)2.32055397
86Hypoglycemic seizures (HP:0002173)2.30946031
87Hypochromic microcytic anemia (HP:0004840)2.26596849
88Abnormal cartilage morphology (HP:0002763)2.26463004
89Lethargy (HP:0001254)2.26293957
90Abnormal gallbladder morphology (HP:0012437)2.24050158
91Ulnar deviation of the wrist (HP:0003049)2.23419327
92Cholelithiasis (HP:0001081)2.23249463
93Dysostosis multiplex (HP:0000943)2.22835793
94Malnutrition (HP:0004395)2.22760512
95Nephritis (HP:0000123)2.22117604
96Generalized aminoaciduria (HP:0002909)2.22018089
97Gingival bleeding (HP:0000225)2.21294467
98Hypertriglyceridemia (HP:0002155)2.20295598
99Blue sclerae (HP:0000592)2.19881755
100Pancreatitis (HP:0001733)2.19777961
101Sensorimotor neuropathy (HP:0007141)2.17860645
102Mitral valve prolapse (HP:0001634)2.17643645
103Cholecystitis (HP:0001082)2.17268306
104Abnormal gallbladder physiology (HP:0012438)2.17268306
105Broad metatarsal (HP:0001783)2.17025445
106Bladder diverticulum (HP:0000015)2.16609245
107Late onset (HP:0003584)2.16192526
108Neonatal onset (HP:0003623)2.15334964
109Eczematoid dermatitis (HP:0000976)2.15113982
110Round ear (HP:0100830)2.14125658
111Ankle contracture (HP:0006466)2.12254047
112Menorrhagia (HP:0000132)2.11479132
113Acanthocytosis (HP:0001927)2.10112675
114Slender build (HP:0001533)2.07244167
115Spondylolisthesis (HP:0003302)2.06985586
116Soft skin (HP:0000977)2.06267362
117Wormian bones (HP:0002645)2.05446804
118Hyperuricemia (HP:0002149)2.03802032
119Increased purine levels (HP:0004368)2.03802032
120Muscle fiber splitting (HP:0003555)2.03750978
121Atrophic scars (HP:0001075)2.02317997
122Irritability (HP:0000737)2.02203986
123Thrombophlebitis (HP:0004418)2.01701665
124Fragile skin (HP:0001030)2.01650509
125Joint stiffness (HP:0001387)2.01508562
126Obstructive sleep apnea (HP:0002870)2.01055193
127Vomiting (HP:0002013)1.97515502
128Distal lower limb muscle weakness (HP:0009053)1.97078448
129Muscle fiber inclusion bodies (HP:0100299)1.96125894
130Enlarged kidneys (HP:0000105)1.94915624
131Thin bony cortex (HP:0002753)1.94244963
132Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93556314
133Spontaneous hematomas (HP:0007420)1.93040448
134Shallow orbits (HP:0000586)1.92656806
135Nemaline bodies (HP:0003798)1.91647972
136Osteolytic defects of the phalanges of the hand (HP:0009771)1.91283412
137Osteolytic defects of the hand bones (HP:0009699)1.91283412
138Proximal tubulopathy (HP:0000114)1.91144693
139Ovoid vertebral bodies (HP:0003300)1.89478880
140Follicular hyperkeratosis (HP:0007502)1.88983834
141Abnormality of iron homeostasis (HP:0011031)1.88251884
142Abnormal enzyme/coenzyme activity (HP:0012379)1.87049957
143Abnormality of transition element cation homeostasis (HP:0011030)1.86638169
144Purpura (HP:0000979)1.86510578
145Brushfield spots (HP:0001088)1.85358705
146Neonatal short-limb short stature (HP:0008921)1.83843060
147Hyperinsulinemic hypoglycemia (HP:0000825)1.83012487
148Abnormality of the gallbladder (HP:0005264)1.82816753
149Cerebral edema (HP:0002181)1.81005902
150Striae distensae (HP:0001065)1.79848811
151Alkalosis (HP:0001948)1.79509528
152Emphysema (HP:0002097)1.78339901
153Biconcave vertebral bodies (HP:0004586)1.78057901
154Joint laxity (HP:0001388)1.77884680
155Polycythemia (HP:0001901)1.77789223
156Hyporeflexia of lower limbs (HP:0002600)1.77740080
157Hyperglycemia (HP:0003074)1.77616078
158Opisthotonus (HP:0002179)1.77436821
159Abnormality of the Achilles tendon (HP:0005109)1.76197417
160Gastrointestinal infarctions (HP:0005244)1.73733166
161Rickets (HP:0002748)1.73322513
162Abnormal delivery (HP:0001787)1.72500846
163Peritonitis (HP:0002586)1.72253367
164Centrally nucleated skeletal muscle fibers (HP:0003687)1.70891142
165Broad face (HP:0000283)1.67603735
166Distal lower limb amyotrophy (HP:0008944)1.67313458
167Gingivitis (HP:0000230)1.67189984
168Aortic regurgitation (HP:0001659)1.67095642
169Abnormality of glycolipid metabolism (HP:0010969)1.66562027
170Abnormality of glycosphingolipid metabolism (HP:0004343)1.66562027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.31480794
2ERN14.62954017
3SIK13.91586528
4FGFR43.74512595
5TRIB33.71150977
6PKN22.49334389
7MST1R2.34467333
8PRPF4B2.32915971
9TAOK32.31866568
10INSRR2.28789090
11CAMK1D2.04835540
12LATS11.96204773
13ERBB41.94064654
14TGFBR21.86825231
15PTK61.75239985
16CDC42BPA1.67872105
17FLT31.67311566
18RIPK11.64716150
19NEK91.64598229
20FRK1.59355620
21ICK1.58614749
22TYK21.55921824
23MAPK111.51163794
24OBSCN1.45234136
25EPHB11.41206228
26MAP3K131.41167070
27PIK3CG1.40404946
28FGFR21.37130482
29BLK1.36497240
30TIE11.34122729
31MAP2K31.33521154
32TRPM71.31229109
33CAMK1G1.30682436
34JAK11.23499156
35KDR1.20658485
36PRKAA21.18773852
37PRKD21.18349853
38MAP3K71.17771886
39AKT31.17317571
40PDGFRA1.16778059
41TTN1.14411847
42MAP3K31.14227800
43MAP2K41.12521673
44MAP3K101.11864022
45MAPK71.11813674
46MET1.10902820
47JAK21.09663396
48MARK21.08028589
49SMG11.05528271
50MAPKAPK31.04962090
51ABL21.04353159
52EPHA31.04089282
53FGFR31.01832179
54TBK11.00663725
55CDK61.00406555
56HIPK20.92994740
57CDK120.91443707
58NLK0.86991609
59PTK20.86687048
60MAP3K10.84521503
61MYLK0.82863072
62MOS0.82624860
63EPHA20.81814861
64CSK0.81728606
65RPS6KA20.81164288
66LRRK20.78483929
67GSK3A0.78425620
68STK380.77711399
69MAP4K10.74747492
70PDK40.74557030
71PDK30.74557030
72IRAK30.70150608
73STK38L0.69502640
74ERBB20.68605335
75MTOR0.67331176
76MAPK40.66688177
77GRK60.65787965
78DAPK20.63539903
79PRKAA10.60999279
80EPHB20.60650566
81BMX0.60287135
82CSF1R0.60005511
83FER0.59509841
84SGK30.59485262
85RPS6KL10.58338590
86RPS6KC10.58338590
87PDPK10.58070089
88MAP2K10.57972941
89MAPK120.56585387
90HCK0.56281445
91DYRK1B0.55966196
92PTK2B0.55728000
93PHKG10.55446709
94PHKG20.55446709
95ZAP700.54815703
96KSR20.54371431
97MELK0.54252189
98PRKACG0.53205079
99MAP3K140.52522064
100STK30.52496510
101RET0.51723312
102PRKCZ0.49738205
103CHUK0.49698629
104RPS6KA60.49212185
105JAK30.48363971
106TNK20.47284592
107IGF1R0.46379593
108MAP3K20.45618693
109FES0.45469167
110MAP3K60.44847839
111PAK20.44539840
112BTK0.43688353
113TAOK20.42945173
114WNK10.42616775
115MAP3K110.42612807
116PIK3CA0.41547848
117MAP2K60.40863080
118IRAK10.40771353
119SGK20.40577116
120KIT0.40284554
121PAK40.40074117
122EGFR0.39380702
123IKBKE0.38364750
124PINK10.38304842
125PDK20.37637514
126CDK40.37592231
127PRKCH0.37300789
128WNK40.37277055
129LMTK20.37173257
130DDR20.36001465
131PDGFRB0.34552953
132PRKD10.34029663
133FGFR10.33996372
134MAP2K20.32506003
135LATS20.32437182
136PDK10.31428843
137MAPK150.31364907
138CAMK2G0.30851472
139ABL10.30724540
140EEF2K0.30399871

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.20000759
2Nitrogen metabolism_Homo sapiens_hsa009103.55927519
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15497362
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06693128
5Arginine biosynthesis_Homo sapiens_hsa002202.86067238
6Complement and coagulation cascades_Homo sapiens_hsa046102.85497254
7Fatty acid degradation_Homo sapiens_hsa000712.71220518
8Tryptophan metabolism_Homo sapiens_hsa003802.65199314
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62835275
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59672543
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45248515
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35586847
13PPAR signaling pathway_Homo sapiens_hsa033202.25224302
14Propanoate metabolism_Homo sapiens_hsa006402.23970204
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18760400
16Peroxisome_Homo sapiens_hsa041462.10384840
17Butanoate metabolism_Homo sapiens_hsa006502.06655108
18Fatty acid metabolism_Homo sapiens_hsa012122.05439772
19Staphylococcus aureus infection_Homo sapiens_hsa051501.96682409
20Caffeine metabolism_Homo sapiens_hsa002321.93856842
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92793160
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78628921
23beta-Alanine metabolism_Homo sapiens_hsa004101.77067209
24Chemical carcinogenesis_Homo sapiens_hsa052041.75957347
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73466192
26Histidine metabolism_Homo sapiens_hsa003401.71523672
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.69253678
28Retinol metabolism_Homo sapiens_hsa008301.53478698
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53240568
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.53061244
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52045681
32Selenocompound metabolism_Homo sapiens_hsa004501.52011218
33Pyruvate metabolism_Homo sapiens_hsa006201.51192488
34Phenylalanine metabolism_Homo sapiens_hsa003601.49957535
35Bile secretion_Homo sapiens_hsa049761.45998370
36Tyrosine metabolism_Homo sapiens_hsa003501.34274292
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33301418
38Starch and sucrose metabolism_Homo sapiens_hsa005001.32041993
39ABC transporters_Homo sapiens_hsa020101.25419834
40Sulfur metabolism_Homo sapiens_hsa009201.24549207
41Fat digestion and absorption_Homo sapiens_hsa049751.23689608
42* Carbon metabolism_Homo sapiens_hsa012001.22742051
43Fatty acid elongation_Homo sapiens_hsa000621.20678821
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19869460
45Biosynthesis of amino acids_Homo sapiens_hsa012301.16821065
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.13015499
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12238362
48Focal adhesion_Homo sapiens_hsa045101.05775551
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03027648
50Folate biosynthesis_Homo sapiens_hsa007901.01956856
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93052913
52Steroid biosynthesis_Homo sapiens_hsa001000.92938838
53Lysine degradation_Homo sapiens_hsa003100.92356279
54Glycerolipid metabolism_Homo sapiens_hsa005610.92223346
55Vitamin digestion and absorption_Homo sapiens_hsa049770.90124498
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.90067270
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89928122
58Arachidonic acid metabolism_Homo sapiens_hsa005900.88820077
59Fatty acid biosynthesis_Homo sapiens_hsa000610.88736631
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88609224
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.88377914
62Osteoclast differentiation_Homo sapiens_hsa043800.88104213
63Sulfur relay system_Homo sapiens_hsa041220.85052386
64Arginine and proline metabolism_Homo sapiens_hsa003300.84921128
65Vitamin B6 metabolism_Homo sapiens_hsa007500.84543169
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82012292
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79920153
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76451385
69Leishmaniasis_Homo sapiens_hsa051400.75143905
70Acute myeloid leukemia_Homo sapiens_hsa052210.73650150
71Glutathione metabolism_Homo sapiens_hsa004800.72035754
72Toxoplasmosis_Homo sapiens_hsa051450.71642135
73Notch signaling pathway_Homo sapiens_hsa043300.68247973
74Dilated cardiomyopathy_Homo sapiens_hsa054140.68144680
75Platelet activation_Homo sapiens_hsa046110.64851313
76TNF signaling pathway_Homo sapiens_hsa046680.64685807
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64385208
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.61769359
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.58080074
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56273842
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.56191814
82Proteoglycans in cancer_Homo sapiens_hsa052050.55488998
83One carbon pool by folate_Homo sapiens_hsa006700.53699818
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.53660527
85Chronic myeloid leukemia_Homo sapiens_hsa052200.53127679
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50936008
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49939250
88VEGF signaling pathway_Homo sapiens_hsa043700.49886091
89B cell receptor signaling pathway_Homo sapiens_hsa046620.48509289
90Insulin resistance_Homo sapiens_hsa049310.47882875
91Tuberculosis_Homo sapiens_hsa051520.47744646
92Prolactin signaling pathway_Homo sapiens_hsa049170.47610505
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46567025
94GnRH signaling pathway_Homo sapiens_hsa049120.46245261
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.45922470
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44306179
97* Pentose phosphate pathway_Homo sapiens_hsa000300.44025932
98African trypanosomiasis_Homo sapiens_hsa051430.43306923
99Allograft rejection_Homo sapiens_hsa053300.42298968
100Prion diseases_Homo sapiens_hsa050200.41151428
101Dorso-ventral axis formation_Homo sapiens_hsa043200.40711820
102Viral myocarditis_Homo sapiens_hsa054160.40687376
103Small cell lung cancer_Homo sapiens_hsa052220.39986692
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.38407767
105Choline metabolism in cancer_Homo sapiens_hsa052310.38384152
106Pancreatic cancer_Homo sapiens_hsa052120.38100835
107Influenza A_Homo sapiens_hsa051640.37666683
108* Metabolic pathways_Homo sapiens_hsa011000.37487401
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.37209797
110Renal cell carcinoma_Homo sapiens_hsa052110.37125213
111Hematopoietic cell lineage_Homo sapiens_hsa046400.35625573
112FoxO signaling pathway_Homo sapiens_hsa040680.35427155
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35122201
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34935564
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33016519
116Fructose and mannose metabolism_Homo sapiens_hsa000510.29900780
117AMPK signaling pathway_Homo sapiens_hsa041520.27714979
118Galactose metabolism_Homo sapiens_hsa000520.27119433
119Glucagon signaling pathway_Homo sapiens_hsa049220.20101466
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.19337175
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19332635
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.14776598
123Linoleic acid metabolism_Homo sapiens_hsa005910.07851962
124Insulin signaling pathway_Homo sapiens_hsa049100.07818531
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06291083
126Amoebiasis_Homo sapiens_hsa051460.04914739
127ECM-receptor interaction_Homo sapiens_hsa045120.02297189
128Lysosome_Homo sapiens_hsa041420.01184800
129Renin-angiotensin system_Homo sapiens_hsa046140.00406873
130Malaria_Homo sapiens_hsa05144-0.1161035
131Other glycan degradation_Homo sapiens_hsa00511-0.0990446
132Pertussis_Homo sapiens_hsa05133-0.0852773
133Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0841374
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0821481
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0807043
136Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0790803
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0766870
138Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0733143
139Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0694890
140Hepatitis C_Homo sapiens_hsa05160-0.0643992
141Bladder cancer_Homo sapiens_hsa05219-0.0591113
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0156369
143Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0093717
144Protein digestion and absorption_Homo sapiens_hsa04974-0.0086605

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