H3F3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. Pseudogenes of this gene have been identified on the X chromosome, and on chromosomes 5, 13 and 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.51428348
2viral mRNA export from host cell nucleus (GO:0046784)3.91181635
3L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.84942368
4regulation of cilium movement (GO:0003352)3.76922280
5proteasome assembly (GO:0043248)3.75810180
6neural tube formation (GO:0001841)3.75169470
7protein-cofactor linkage (GO:0018065)3.69589145
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.68562534
9CENP-A containing nucleosome assembly (GO:0034080)3.67328430
10piRNA metabolic process (GO:0034587)3.63644828
11cullin deneddylation (GO:0010388)3.53813821
12amino acid salvage (GO:0043102)3.48801671
13L-methionine salvage (GO:0071267)3.48801671
14L-methionine biosynthetic process (GO:0071265)3.48801671
15protein deneddylation (GO:0000338)3.46290048
16chromatin remodeling at centromere (GO:0031055)3.44469140
17behavioral response to nicotine (GO:0035095)3.42075368
18DNA deamination (GO:0045006)3.42031939
19platelet dense granule organization (GO:0060155)3.30554175
20maturation of SSU-rRNA (GO:0030490)3.28376836
21DNA double-strand break processing (GO:0000729)3.27281031
22DNA replication-independent nucleosome organization (GO:0034724)3.24787529
23DNA replication-independent nucleosome assembly (GO:0006336)3.24787529
24DNA ligation (GO:0006266)3.24503078
25attachment of spindle microtubules to kinetochore (GO:0008608)3.24403666
26protein complex biogenesis (GO:0070271)3.24225891
27protein localization to cilium (GO:0061512)3.23308241
28telomere maintenance via semi-conservative replication (GO:0032201)3.19762524
29ribosomal small subunit biogenesis (GO:0042274)3.19134067
30kinetochore organization (GO:0051383)3.18348967
31pyrimidine nucleobase catabolic process (GO:0006208)3.14577380
32GPI anchor metabolic process (GO:0006505)3.13016733
33positive regulation of mitochondrial fission (GO:0090141)3.11689431
34preassembly of GPI anchor in ER membrane (GO:0016254)3.11400138
35telomere maintenance via recombination (GO:0000722)3.08529303
36fucose catabolic process (GO:0019317)3.08485920
37L-fucose metabolic process (GO:0042354)3.08485920
38L-fucose catabolic process (GO:0042355)3.08485920
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07467078
40response to pheromone (GO:0019236)3.06550389
41metallo-sulfur cluster assembly (GO:0031163)3.05127113
42iron-sulfur cluster assembly (GO:0016226)3.05127113
43protein polyglutamylation (GO:0018095)3.01607060
44mitotic recombination (GO:0006312)3.01518557
45retinal cone cell development (GO:0046549)3.01189560
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00484310
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.99416207
48mitochondrial respiratory chain complex assembly (GO:0033108)2.99323222
49negative regulation of telomere maintenance (GO:0032205)2.98737440
50indole-containing compound catabolic process (GO:0042436)2.98189433
51indolalkylamine catabolic process (GO:0046218)2.98189433
52tryptophan catabolic process (GO:0006569)2.98189433
53viral transcription (GO:0019083)2.98011945
54RNA capping (GO:0036260)2.93809754
557-methylguanosine RNA capping (GO:0009452)2.93809754
56tryptophan metabolic process (GO:0006568)2.92692518
57indolalkylamine metabolic process (GO:0006586)2.92651123
587-methylguanosine mRNA capping (GO:0006370)2.92074100
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91880000
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91409827
61DNA strand elongation involved in DNA replication (GO:0006271)2.90775200
62termination of RNA polymerase III transcription (GO:0006386)2.89880774
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.89880774
64histone H2A acetylation (GO:0043968)2.89657044
65kinetochore assembly (GO:0051382)2.88715260
66mannosylation (GO:0097502)2.88365825
67mitochondrial respiratory chain complex I assembly (GO:0032981)2.88205789
68NADH dehydrogenase complex assembly (GO:0010257)2.88205789
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88205789
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88199560
71water-soluble vitamin biosynthetic process (GO:0042364)2.88179860
72respiratory chain complex IV assembly (GO:0008535)2.87085139
73intraciliary transport (GO:0042073)2.86892109
74translational termination (GO:0006415)2.86005038
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85352249
76DNA topological change (GO:0006265)2.84598950
77behavioral response to ethanol (GO:0048149)2.84461156
78DNA strand elongation (GO:0022616)2.83286244
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80084408
80nonmotile primary cilium assembly (GO:0035058)2.79027470
81spliceosomal snRNP assembly (GO:0000387)2.77915205
82histone exchange (GO:0043486)2.76848316
83cytochrome complex assembly (GO:0017004)2.76318901
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76292208
85negative regulation of ligase activity (GO:0051352)2.76292208
86regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.76103851
87regulation of mitotic spindle checkpoint (GO:1903504)2.76103851
88regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.75968658
89gamma-aminobutyric acid transport (GO:0015812)2.75086920
90epithelial cilium movement (GO:0003351)2.74063655
91spliceosomal complex assembly (GO:0000245)2.73552069
92transcription-coupled nucleotide-excision repair (GO:0006283)2.73027038
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.72464125
94organelle disassembly (GO:1903008)2.70847153
95GPI anchor biosynthetic process (GO:0006506)2.70334187
96DNA catabolic process, exonucleolytic (GO:0000738)2.70059880
97ribosomal large subunit biogenesis (GO:0042273)2.69992365
98DNA replication initiation (GO:0006270)2.68697644
99base-excision repair, AP site formation (GO:0006285)2.68388556
100histone mRNA metabolic process (GO:0008334)2.68359113
101cotranslational protein targeting to membrane (GO:0006613)2.67989936
102termination of RNA polymerase II transcription (GO:0006369)2.67987731
103protein neddylation (GO:0045116)2.66980964
104termination of RNA polymerase I transcription (GO:0006363)2.66091871
105DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65609295
106kynurenine metabolic process (GO:0070189)2.64998404
107DNA-templated transcription, termination (GO:0006353)2.64187784
108telomere maintenance via telomere lengthening (GO:0010833)2.63638323
109protein targeting to ER (GO:0045047)2.63042289
110pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.63041010
111axoneme assembly (GO:0035082)2.62743542
112mitotic metaphase plate congression (GO:0007080)2.62521028
113signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.62340540
114signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.62340540
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.62340540
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.61920152
117negative regulation of sister chromatid segregation (GO:0033046)2.61920152
118negative regulation of mitotic sister chromatid separation (GO:2000816)2.61920152
119negative regulation of mitotic sister chromatid segregation (GO:0033048)2.61920152
120transcription elongation from RNA polymerase I promoter (GO:0006362)2.60735323
121purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.60664166
122RNA splicing, via transesterification reactions (GO:0000375)2.60614653
123cilium morphogenesis (GO:0060271)2.60413674
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.60214046
125ribonucleoprotein complex biogenesis (GO:0022613)2.59766957
126intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.59663435
127signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.59663435
128spindle assembly checkpoint (GO:0071173)2.59563250
129aggressive behavior (GO:0002118)2.59265465
130RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.59044742
131mRNA splicing, via spliceosome (GO:0000398)2.59044742
132DNA methylation involved in gamete generation (GO:0043046)2.58600614
133DNA demethylation (GO:0080111)2.58565599
134prenylation (GO:0097354)2.58358818
135protein prenylation (GO:0018342)2.58358818
136signal transduction involved in cell cycle checkpoint (GO:0072395)2.57634302
137negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.55995471
138mitotic spindle assembly checkpoint (GO:0007094)2.54899366
139maturation of 5.8S rRNA (GO:0000460)2.54710810
140epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.54679495
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53016084
142tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53016084
143negative regulation of RNA splicing (GO:0033119)2.52439160
144signal transduction involved in DNA integrity checkpoint (GO:0072401)2.51860669
145signal transduction involved in DNA damage checkpoint (GO:0072422)2.51860669
146negative regulation of chromosome segregation (GO:0051985)2.51731479
147protein localization to endoplasmic reticulum (GO:0070972)2.51095119
148negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49876603
149S-adenosylmethionine metabolic process (GO:0046500)2.49429341
150regulation of cellular amino acid metabolic process (GO:0006521)2.48847571
151meiotic chromosome segregation (GO:0045132)2.48712986
152mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.48708828
153spindle checkpoint (GO:0031577)2.48077963
154sequestering of actin monomers (GO:0042989)2.47234138
155viral life cycle (GO:0019058)2.46569064
156regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.45040519
157positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.44605062
158metaphase plate congression (GO:0051310)2.44527588
159establishment of protein localization to endoplasmic reticulum (GO:0072599)2.44098872
160antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.43951494
161methionine biosynthetic process (GO:0009086)2.43813484
162nucleobase catabolic process (GO:0046113)2.42587771
163translational elongation (GO:0006414)2.42561425
164photoreceptor cell maintenance (GO:0045494)2.41837439
165auditory receptor cell stereocilium organization (GO:0060088)2.41780565
166cilium organization (GO:0044782)2.41663166
167transcription elongation from RNA polymerase II promoter (GO:0006368)2.41189548
168protein K11-linked ubiquitination (GO:0070979)2.40600518
169centriole assembly (GO:0098534)2.40298666
170ATP-dependent chromatin remodeling (GO:0043044)2.40147969
171RNA destabilization (GO:0050779)2.40072568
172negative regulation of DNA recombination (GO:0045910)2.39955440
173nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.39706124
174centriole replication (GO:0007099)2.38800177
175microtubule depolymerization (GO:0007019)2.38523814
176DNA damage response, detection of DNA damage (GO:0042769)2.37997643
177viral protein processing (GO:0019082)2.37197437
178male meiosis (GO:0007140)2.36493432
179regulation of microtubule-based movement (GO:0060632)2.35534618
180DNA integration (GO:0015074)2.35527772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.10752361
2ZNF274_21170338_ChIP-Seq_K562_Hela4.06472599
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48071727
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.47400802
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.42594117
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.40819802
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40600133
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22672363
9* EST1_17652178_ChIP-ChIP_JURKAT_Human3.17804386
10IGF1R_20145208_ChIP-Seq_DFB_Human3.00015154
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98761100
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85038462
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80762753
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79497122
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.77240207
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72031805
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.60690531
18* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59895050
19* VDR_23849224_ChIP-Seq_CD4+_Human2.58424107
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53331133
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52358754
22VDR_22108803_ChIP-Seq_LS180_Human2.51635996
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.50056595
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49991509
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48888973
26ELK1_19687146_ChIP-ChIP_HELA_Human2.47822173
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34827654
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34740009
29HOXB4_20404135_ChIP-ChIP_EML_Mouse2.31072529
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27443661
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25236262
32* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20777642
33FUS_26573619_Chip-Seq_HEK293_Human2.19153272
34ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17027609
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.16208099
36* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13210357
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11852834
38* XRN2_22483619_ChIP-Seq_HELA_Human2.10565750
39GBX2_23144817_ChIP-Seq_PC3_Human2.10101176
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09552600
41MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08765897
42TAF15_26573619_Chip-Seq_HEK293_Human2.08298840
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03650882
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02974598
45* TTF2_22483619_ChIP-Seq_HELA_Human1.93848917
46* FOXP3_21729870_ChIP-Seq_TREG_Human1.90804334
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89042957
48* DCP1A_22483619_ChIP-Seq_HELA_Human1.87397658
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.80053874
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79723711
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.79316927
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77178787
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75613979
54P300_19829295_ChIP-Seq_ESCs_Human1.74037889
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72740043
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72281636
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70616108
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69032688
59ER_23166858_ChIP-Seq_MCF-7_Human1.66530167
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.62596640
61* GABP_19822575_ChIP-Seq_HepG2_Human1.60662720
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58836304
63TP53_22573176_ChIP-Seq_HFKS_Human1.58761163
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57902878
65CIITA_25753668_ChIP-Seq_RAJI_Human1.56923072
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56809985
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56483294
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55929396
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54660208
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49247737
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48983098
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48254359
73CBP_20019798_ChIP-Seq_JUKART_Human1.47831370
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47831370
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43414110
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41365066
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38990832
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.37776031
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36247516
80AR_21909140_ChIP-Seq_LNCAP_Human1.34885763
81* E2F1_21310950_ChIP-Seq_MCF-7_Human1.34791310
82TP63_17297297_ChIP-ChIP_HaCaT_Human1.34745707
83SCL_19346495_ChIP-Seq_HPC-7_Human1.33918181
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33511129
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31930386
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.31718866
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30627097
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30032308
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29951581
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29722683
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27303587
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27066979
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24841412
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24583087
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23880652
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23756283
97* SPI1_23547873_ChIP-Seq_NB4_Human1.22991653
98* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22778299
99RNF2_27304074_Chip-Seq_NSC_Mouse1.21798748
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21130928
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20116704
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20093250
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20075262
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.19680382
105FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19680382
106NANOG_19829295_ChIP-Seq_ESCs_Human1.19090698
107SOX2_19829295_ChIP-Seq_ESCs_Human1.19090698
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18062442
109MYC_18940864_ChIP-ChIP_HL60_Human1.17621113
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16837989
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16753894
112EWS_26573619_Chip-Seq_HEK293_Human1.15169935
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13893092
114AR_20517297_ChIP-Seq_VCAP_Human1.12679361
115IRF1_19129219_ChIP-ChIP_H3396_Human1.12293651
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.10664555
117NCOR_22424771_ChIP-Seq_293T_Human1.10436332
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10374130
119PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10109661
120NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08217882
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08170468
122PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08145256
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05768878
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04936997
125EGR1_19374776_ChIP-ChIP_THP-1_Human1.04236320
126ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03641831
127BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03021268
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02597915
129BCAT_22108803_ChIP-Seq_LS180_Human1.02588642
130AR_25329375_ChIP-Seq_VCAP_Human1.02389235
131KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02359676
132EZH2_27294783_Chip-Seq_NPCs_Mouse1.02138607
133GATA3_21878914_ChIP-Seq_MCF-7_Human1.01413599
134NANOG_16153702_ChIP-ChIP_HESCs_Human1.01109562
135* GATA3_26560356_Chip-Seq_TH2_Human1.01066762
136STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00578782
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99386680
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99386680
139CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99040889
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98720502
141FLI1_21867929_ChIP-Seq_TH2_Mouse0.97236732
142SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97093701
143NFE2_27457419_Chip-Seq_LIVER_Mouse0.96940033
144KDM5A_27292631_Chip-Seq_BREAST_Human0.95613177
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94424646
146SMAD4_21799915_ChIP-Seq_A2780_Human0.93654612
147TCF4_22108803_ChIP-Seq_LS180_Human0.93112704
148IRF8_22096565_ChIP-ChIP_GC-B_Human0.93017949
149PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91815466
150FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91674825
151FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91144127
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90317922
153SALL4_22934838_ChIP-ChIP_CD34+_Human0.90258290
154MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87231267
155E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87178105
156MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85223634
157* SOX2_16153702_ChIP-ChIP_HESCs_Human0.83763053
158CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83345310
159BP1_19119308_ChIP-ChIP_Hs578T_Human0.80307070
160* SOX17_20123909_ChIP-Seq_XEN_Mouse0.79094029
161PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78745306
162HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76099633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.15528492
2MP0008058_abnormal_DNA_repair2.79589572
3MP0006292_abnormal_olfactory_placode2.71490862
4MP0008007_abnormal_cellular_replicative2.69056115
5MP0010094_abnormal_chromosome_stability2.67253516
6MP0003880_abnormal_central_pattern2.59292318
7MP0006276_abnormal_autonomic_nervous2.45803629
8MP0003077_abnormal_cell_cycle2.34934652
9MP0005646_abnormal_pituitary_gland2.22029193
10MP0003786_premature_aging2.21413447
11MP0004957_abnormal_blastocyst_morpholog2.18636725
12MP0001529_abnormal_vocalization2.14676107
13MP0001984_abnormal_olfaction2.10301194
14MP0003111_abnormal_nucleus_morphology2.07352822
15MP0010030_abnormal_orbit_morphology2.03198097
16MP0001968_abnormal_touch/_nociception2.00205869
17MP0008789_abnormal_olfactory_epithelium1.97975319
18MP0002938_white_spotting1.96783490
19MP0008995_early_reproductive_senescence1.92800823
20MP0005084_abnormal_gallbladder_morpholo1.88191984
21MP0002736_abnormal_nociception_after1.87302645
22MP0005551_abnormal_eye_electrophysiolog1.83261156
23MP0008057_abnormal_DNA_replication1.80277500
24MP0002396_abnormal_hematopoietic_system1.74755408
25MP0000566_synostosis1.74615931
26MP0005253_abnormal_eye_physiology1.74607180
27MP0002132_abnormal_respiratory_system1.73094339
28MP0009046_muscle_twitch1.70611178
29MP0003315_abnormal_perineum_morphology1.69205501
30MP0003941_abnormal_skin_development1.66056865
31MP0008877_abnormal_DNA_methylation1.65647077
32MP0009379_abnormal_foot_pigmentation1.60572423
33MP0002009_preneoplasia1.60163754
34MP0001501_abnormal_sleep_pattern1.59779002
35MP0002638_abnormal_pupillary_reflex1.58518634
36MP0002277_abnormal_respiratory_mucosa1.58369973
37MP0004142_abnormal_muscle_tone1.55717932
38MP0005075_abnormal_melanosome_morpholog1.54708518
39MP0008932_abnormal_embryonic_tissue1.54125959
40MP0004808_abnormal_hematopoietic_stem1.52881350
41MP0001835_abnormal_antigen_presentation1.50364415
42MP0008875_abnormal_xenobiotic_pharmacok1.47071554
43MP0002138_abnormal_hepatobiliary_system1.46848488
44MP0001486_abnormal_startle_reflex1.46083354
45MP0002095_abnormal_skin_pigmentation1.44975378
46MP0003195_calcinosis1.43567108
47MP0003763_abnormal_thymus_physiology1.42117530
48MP0005645_abnormal_hypothalamus_physiol1.41878650
49MP0001188_hyperpigmentation1.41804330
50MP0009745_abnormal_behavioral_response1.40432769
51MP0002272_abnormal_nervous_system1.38847297
52MP0000490_abnormal_crypts_of1.38507820
53MP0001986_abnormal_taste_sensitivity1.37283780
54MP0004147_increased_porphyrin_level1.36103826
55MP0000383_abnormal_hair_follicle1.35928386
56MP0000465_gastrointestinal_hemorrhage1.35716655
57MP0009764_decreased_sensitivity_to1.34879477
58MP0003011_delayed_dark_adaptation1.34596863
59MP0000049_abnormal_middle_ear1.33617213
60MP0000516_abnormal_urinary_system1.31943817
61MP0005367_renal/urinary_system_phenotyp1.31943817
62MP0002653_abnormal_ependyma_morphology1.30106579
63MP0002148_abnormal_hypersensitivity_rea1.29892591
64MP0002102_abnormal_ear_morphology1.27720205
65MP0008872_abnormal_physiological_respon1.23577771
66MP0006035_abnormal_mitochondrial_morpho1.23269855
67MP0003943_abnormal_hepatobiliary_system1.23253752
68MP0002822_catalepsy1.22871616
69MP0009785_altered_susceptibility_to1.22784073
70MP0003122_maternal_imprinting1.21834383
71MP0001764_abnormal_homeostasis1.17566616
72MP0002210_abnormal_sex_determination1.15153122
73MP0005499_abnormal_olfactory_system1.14576062
74MP0005394_taste/olfaction_phenotype1.14576062
75MP0001346_abnormal_lacrimal_gland1.14475398
76MP0003718_maternal_effect1.12701704
77MP0003724_increased_susceptibility_to1.12191980
78MP0002572_abnormal_emotion/affect_behav1.11999931
79MP0004782_abnormal_surfactant_physiolog1.08619269
80MP0001919_abnormal_reproductive_system1.08270312
81MP0006072_abnormal_retinal_apoptosis1.08056361
82MP0000372_irregular_coat_pigmentation1.06468028
83MP0002735_abnormal_chemical_nociception1.05031667
84MP0001929_abnormal_gametogenesis1.03102759
85MP0005671_abnormal_response_to1.02366983
86MP0002098_abnormal_vibrissa_morphology1.02036821
87MP0001853_heart_inflammation1.01640002
88MP0001905_abnormal_dopamine_level1.00973075
89MP0001119_abnormal_female_reproductive1.00880255
90MP0001502_abnormal_circadian_rhythm0.99885368
91MP0001286_abnormal_eye_development0.99557889
92MP0002733_abnormal_thermal_nociception0.99482066
93MP0005386_behavior/neurological_phenoty0.98977773
94MP0004924_abnormal_behavior0.98977773
95MP0005389_reproductive_system_phenotype0.98852323
96MP0004381_abnormal_hair_follicle0.98442956
97MP0005397_hematopoietic_system_phenotyp0.98179809
98MP0001545_abnormal_hematopoietic_system0.98179809
99MP0002398_abnormal_bone_marrow0.97990921
100MP0002282_abnormal_trachea_morphology0.97231976
101MP0003937_abnormal_limbs/digits/tail_de0.97090253
102MP0002557_abnormal_social/conspecific_i0.96683977
103MP0002234_abnormal_pharynx_morphology0.96541074
104MP0004133_heterotaxia0.96013654
105MP0000427_abnormal_hair_cycle0.95725416
106MP0000647_abnormal_sebaceous_gland0.95605997
107MP0005174_abnormal_tail_pigmentation0.95425405
108MP0002751_abnormal_autonomic_nervous0.94997783
109MP0003121_genomic_imprinting0.93857922
110MP0000350_abnormal_cell_proliferation0.93747591
111MP0004885_abnormal_endolymph0.92581149
112MP0001970_abnormal_pain_threshold0.91880215
113MP0001293_anophthalmia0.91719938
114MP0006036_abnormal_mitochondrial_physio0.91226148
115MP0002928_abnormal_bile_duct0.91221961
116MP0000703_abnormal_thymus_morphology0.90706435
117MP0000015_abnormal_ear_pigmentation0.90534662
118MP0003938_abnormal_ear_development0.90381314
119MP0000313_abnormal_cell_death0.90332645
120MP0003698_abnormal_male_reproductive0.89895196
121MP0002233_abnormal_nose_morphology0.88582459
122MP0005408_hypopigmentation0.88372464
123MP0004043_abnormal_pH_regulation0.87374315
124MP0009333_abnormal_splenocyte_physiolog0.87246652
125MP0001873_stomach_inflammation0.87142598
126MP0002452_abnormal_antigen_presenting0.86970123
127MP0009278_abnormal_bone_marrow0.86118183
128MP0002420_abnormal_adaptive_immunity0.86002879
129MP0002876_abnormal_thyroid_physiology0.85891297
130MP0005410_abnormal_fertilization0.85735727
131MP0002177_abnormal_outer_ear0.85440308
132MP0001145_abnormal_male_reproductive0.85098543
133MP0001819_abnormal_immune_cell0.84558493
134MP0005000_abnormal_immune_tolerance0.84202152
135MP0002405_respiratory_system_inflammati0.83880424
136MP0002064_seizures0.83645145
137MP0000653_abnormal_sex_gland0.82072762
138MP0003942_abnormal_urinary_system0.81552112
139MP0010155_abnormal_intestine_physiology0.81143323
140MP0002722_abnormal_immune_system0.80813885
141MP0009697_abnormal_copulation0.80405210
142MP0006054_spinal_hemorrhage0.79457962
143MP0000631_abnormal_neuroendocrine_gland0.79375162
144MP0004742_abnormal_vestibular_system0.79125090
145MP0000569_abnormal_digit_pigmentation0.78469318
146MP0000689_abnormal_spleen_morphology0.78112798
147MP0002019_abnormal_tumor_incidence0.77656921
148MP0005423_abnormal_somatic_nervous0.77637528
149MP0000716_abnormal_immune_system0.77508387
150MP0000613_abnormal_salivary_gland0.77083888
151MP0001800_abnormal_humoral_immune0.76561636
152MP0002723_abnormal_immune_serum0.75984233
153MP0005025_abnormal_response_to0.75948246
154MP0003787_abnormal_imprinting0.75932267
155MP0003635_abnormal_synaptic_transmissio0.75665886
156MP0001186_pigmentation_phenotype0.75497178
157MP0000681_abnormal_thyroid_gland0.74585816
158MP0000537_abnormal_urethra_morphology0.74249953
159MP0000678_abnormal_parathyroid_gland0.74132922
160MP0002063_abnormal_learning/memory/cond0.73343354
161MP0005391_vision/eye_phenotype0.73156665
162MP0002752_abnormal_somatic_nervous0.71779972
163MP0009765_abnormal_xenobiotic_induced0.70370432
164MP0001485_abnormal_pinna_reflex0.70047267
165MP0002067_abnormal_sensory_capabilities0.69718566

Predicted human phenotypes

RankGene SetZ-score
1Nephronophthisis (HP:0000090)3.30483489
2True hermaphroditism (HP:0010459)3.22656032
3Methylmalonic acidemia (HP:0002912)3.13002580
4Abnormal number of erythroid precursors (HP:0012131)3.06818309
5Abnormality of cells of the erythroid lineage (HP:0012130)3.01196353
6Reticulocytopenia (HP:0001896)3.00825046
7Gait imbalance (HP:0002141)2.91192909
8Acute necrotizing encephalopathy (HP:0006965)2.91084228
9Birth length less than 3rd percentile (HP:0003561)2.90851231
10Congenital primary aphakia (HP:0007707)2.88091090
11Type II lissencephaly (HP:0007260)2.86579398
12Mitochondrial inheritance (HP:0001427)2.84416601
13Nephrogenic diabetes insipidus (HP:0009806)2.83553343
14Abnormal lung lobation (HP:0002101)2.82596585
15Patellar aplasia (HP:0006443)2.79586449
16Abnormality of the renal medulla (HP:0100957)2.78161911
17Hepatocellular necrosis (HP:0001404)2.74966834
1811 pairs of ribs (HP:0000878)2.74519539
19Abolished electroretinogram (ERG) (HP:0000550)2.73474657
20Increased CSF lactate (HP:0002490)2.72472895
21Abnormal mitochondria in muscle tissue (HP:0008316)2.72186425
22Aplasia/Hypoplasia of the patella (HP:0006498)2.72051394
23Attenuation of retinal blood vessels (HP:0007843)2.70291184
24Aplastic anemia (HP:0001915)2.69504824
25Progressive macrocephaly (HP:0004481)2.65493092
26Pancreatic fibrosis (HP:0100732)2.65024254
27Lissencephaly (HP:0001339)2.63217315
28Chromsome breakage (HP:0040012)2.61407128
29Hepatic necrosis (HP:0002605)2.57929130
30Methylmalonic aciduria (HP:0012120)2.56955068
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55305926
32Congenital stationary night blindness (HP:0007642)2.53093091
33Type I transferrin isoform profile (HP:0003642)2.50083358
34Abnormality of the renal cortex (HP:0011035)2.46174371
35Type 2 muscle fiber atrophy (HP:0003554)2.45803496
36Optic nerve coloboma (HP:0000588)2.43409517
37Acute encephalopathy (HP:0006846)2.43210358
38Pancreatic cysts (HP:0001737)2.38255857
39Bile duct proliferation (HP:0001408)2.38106983
40Abnormal biliary tract physiology (HP:0012439)2.38106983
41Retinal dysplasia (HP:0007973)2.35188233
42Increased hepatocellular lipid droplets (HP:0006565)2.29973632
43Abnormality of the preputium (HP:0100587)2.28742675
44Prostate neoplasm (HP:0100787)2.28614405
45Pendular nystagmus (HP:0012043)2.26637746
46Lipid accumulation in hepatocytes (HP:0006561)2.24742646
47Decreased central vision (HP:0007663)2.24468567
48Muscle fiber atrophy (HP:0100295)2.24312023
49Renal cortical cysts (HP:0000803)2.23808802
50Abnormality of the labia minora (HP:0012880)2.19334496
51Myelodysplasia (HP:0002863)2.17785024
52Optic disc pallor (HP:0000543)2.15386879
53Meckel diverticulum (HP:0002245)2.14650959
54Breast hypoplasia (HP:0003187)2.13455560
55Stomatitis (HP:0010280)2.13060946
56Cystic liver disease (HP:0006706)2.13018863
57Progressive inability to walk (HP:0002505)2.10668761
58Genital tract atresia (HP:0001827)2.10505097
59Vaginal atresia (HP:0000148)2.10099075
60Hyperglycinemia (HP:0002154)2.09784124
61Increased serum lactate (HP:0002151)2.09238325
62Pallor (HP:0000980)2.08942238
63Abnormality of the ileum (HP:0001549)2.06564530
64Tubulointerstitial nephritis (HP:0001970)2.04724681
65Chronic hepatic failure (HP:0100626)2.04624427
66Focal motor seizures (HP:0011153)2.03768125
67Amyotrophic lateral sclerosis (HP:0007354)2.02936233
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02402948
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02402948
70Short tibia (HP:0005736)2.01909108
71Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99929370
72Absent speech (HP:0001344)1.99233947
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98656071
74Facial cleft (HP:0002006)1.97078761
75Congenital hepatic fibrosis (HP:0002612)1.96772796
76Small intestinal stenosis (HP:0012848)1.96754056
77Duodenal stenosis (HP:0100867)1.96754056
78Abnormality of B cell number (HP:0010975)1.96458974
79Aplasia/Hypoplasia of the tibia (HP:0005772)1.96431087
80Lactic acidosis (HP:0003128)1.96421489
81Inability to walk (HP:0002540)1.96241271
82Preaxial hand polydactyly (HP:0001177)1.96034006
83IgM deficiency (HP:0002850)1.95618067
84Abnormality of chromosome stability (HP:0003220)1.93442117
85Abnormality of the intervertebral disk (HP:0005108)1.93250615
86Medial flaring of the eyebrow (HP:0010747)1.91479840
87Hyperventilation (HP:0002883)1.89938130
88Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89183749
89Abnormal respiratory motile cilium morphology (HP:0005938)1.89165748
90Abnormal respiratory epithelium morphology (HP:0012253)1.89165748
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.88756437
92Patchy hypopigmentation of hair (HP:0011365)1.87916811
93Abnormality of the vitamin B12 metabolism (HP:0004341)1.87768225
94Supernumerary spleens (HP:0009799)1.87700942
95Male pseudohermaphroditism (HP:0000037)1.87660969
96Postaxial foot polydactyly (HP:0001830)1.87470471
97Clubbing of toes (HP:0100760)1.86277772
98Elevated erythrocyte sedimentation rate (HP:0003565)1.86024149
99Colon cancer (HP:0003003)1.84473297
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83738815
101Abnormality of alanine metabolism (HP:0010916)1.83738815
102Hyperalaninemia (HP:0003348)1.83738815
103Pachygyria (HP:0001302)1.83442974
104Increased intramyocellular lipid droplets (HP:0012240)1.83375533
105Postaxial hand polydactyly (HP:0001162)1.82596912
106Sclerocornea (HP:0000647)1.82051338
107Bone marrow hypocellularity (HP:0005528)1.82037303
108Gonadotropin excess (HP:0000837)1.81858608
109Abnormality of vitamin B metabolism (HP:0004340)1.81661091
110Abnormality of the renal collecting system (HP:0004742)1.81573261
111Aplasia/hypoplasia of the uterus (HP:0008684)1.81257121
112Congenital, generalized hypertrichosis (HP:0004540)1.81120583
113Cerebral edema (HP:0002181)1.80416996
114Abnormality of male internal genitalia (HP:0000022)1.80023194
115Atrophy/Degeneration involving motor neurons (HP:0007373)1.79985793
116Abnormality of the prostate (HP:0008775)1.79799062
117Abnormality of the heme biosynthetic pathway (HP:0010472)1.79704188
118Anencephaly (HP:0002323)1.79696729
119Molar tooth sign on MRI (HP:0002419)1.79242605
120Abnormality of midbrain morphology (HP:0002418)1.79242605
121Severe combined immunodeficiency (HP:0004430)1.78179638
122Thyroiditis (HP:0100646)1.77783280
123Abnormal spermatogenesis (HP:0008669)1.77559321
124Nephroblastoma (Wilms tumor) (HP:0002667)1.77423803
125Rough bone trabeculation (HP:0100670)1.76956138
126Oral leukoplakia (HP:0002745)1.76734403
127Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76507597
128Limb dystonia (HP:0002451)1.75974255
129Abnormal respiratory motile cilium physiology (HP:0012261)1.75928250
130Abnormal rod and cone electroretinograms (HP:0008323)1.75226885
131Generalized aminoaciduria (HP:0002909)1.75065780
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74029325
133Premature graying of hair (HP:0002216)1.73266865
134Specific learning disability (HP:0001328)1.72775637
135Abnormality of the anterior horn cell (HP:0006802)1.72696764
136Degeneration of anterior horn cells (HP:0002398)1.72696764
137Cleft eyelid (HP:0000625)1.72097030
138Sparse eyelashes (HP:0000653)1.71366978
139Triphalangeal thumb (HP:0001199)1.70194728
140Severe visual impairment (HP:0001141)1.69678831
141Abnormal ciliary motility (HP:0012262)1.69629291
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.69481327
143Absent/shortened dynein arms (HP:0200106)1.69481327
144Stomach cancer (HP:0012126)1.69443500
145Intestinal atresia (HP:0011100)1.68224955
1463-Methylglutaconic aciduria (HP:0003535)1.67638063
147Lip pit (HP:0100267)1.67608796
148Depressed nasal ridge (HP:0000457)1.66682017
149Macrocytic anemia (HP:0001972)1.66271053
150Parakeratosis (HP:0001036)1.65883531
151Aplasia/Hypoplasia of the sternum (HP:0006714)1.65513258
152Abnormal sex determination (HP:0012244)1.65262457
153Sex reversal (HP:0012245)1.65262457
154Abnormality of the duodenum (HP:0002246)1.64376228
155Petechiae (HP:0000967)1.64149481
156Embryonal renal neoplasm (HP:0011794)1.63769088
157Thrombocytosis (HP:0001894)1.62661758
158IgG deficiency (HP:0004315)1.61408517
159Abnormality of the axillary hair (HP:0100134)1.60022326
160Abnormality of secondary sexual hair (HP:0009888)1.60022326
161Median cleft lip (HP:0000161)1.59293022
162Ectopic kidney (HP:0000086)1.59269740
163Lymphoma (HP:0002665)1.58785728
164Volvulus (HP:0002580)1.58244012
165Hypothermia (HP:0002045)1.57222369
166Microretrognathia (HP:0000308)1.56291368
167Abnormal protein glycosylation (HP:0012346)1.55788611
168Abnormal glycosylation (HP:0012345)1.55788611
169Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.55788611
170Abnormal protein N-linked glycosylation (HP:0012347)1.55788611
171Optic neuritis (HP:0100653)1.55097054
172Retrobulbar optic neuritis (HP:0100654)1.55097054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.00146158
2BUB13.33896412
3MKNK13.30872145
4STK163.14784444
5TRIM283.08740900
6TAOK32.70357883
7PLK42.61152787
8SRPK12.55104385
9WEE12.54645209
10ERBB32.54041105
11CCNB12.52278320
12DYRK32.46896332
13VRK12.46444377
14FRK2.35158999
15WNK32.32199504
16ACVR1B2.29391709
17MKNK22.11551018
18BMPR1B2.03969026
19BCKDK1.95059187
20PINK11.92744931
21TGFBR11.92465735
22IRAK41.84377247
23EIF2AK11.80242410
24MAP3K41.71731794
25RPS6KB21.66681722
26DYRK21.58748620
27BRSK21.58106292
28CDC71.52200923
29MAP2K71.50793562
30EPHA21.49088395
31MST41.47421566
32TXK1.43767036
33SIK31.41847028
34EIF2AK31.40788320
35RPS6KA41.33500991
36PBK1.33190516
37CSNK1G21.32091603
38YES11.30109941
39ZAK1.27745531
40EIF2AK21.26407459
41PASK1.23902736
42MAPK151.22423039
43MAPKAPK51.21434498
44BCR1.19606671
45PLK31.18777436
46CDK81.18349879
47PLK11.13913967
48IRAK11.09859937
49TEC1.08408798
50NUAK11.08017806
51IRAK31.07203560
52NEK21.07173698
53ATR1.07001461
54TSSK61.06713853
55MUSK1.05505819
56CDK31.04134107
57PLK21.03850984
58CDK191.03667805
59TGFBR21.01986773
60VRK21.01442942
61INSRR1.00546094
62OXSR10.98463677
63* AURKB0.97472278
64IKBKE0.96658569
65CDK70.96103949
66IRAK20.95516091
67PIM20.90580263
68PRKCE0.89650216
69BTK0.88826484
70MAP3K120.88595885
71CASK0.85998097
72BMPR20.85339633
73NLK0.84264645
74KIT0.84166981
75DYRK1B0.80684067
76BRSK10.80510034
77IKBKB0.80472068
78MAPK130.80446759
79ADRBK20.77510448
80MINK10.76824587
81TNIK0.74182855
82MAP3K50.73054818
83ITK0.72989533
84AURKA0.72976779
85TLK10.71936155
86NME20.70983492
87* RPS6KA50.69014921
88MAP4K10.68663927
89TESK20.68073178
90CSNK1G30.67804160
91CHEK20.67789011
92CLK10.66032807
93TTK0.65594462
94TIE10.65439067
95FES0.64347651
96MAP2K20.62838299
97FLT30.61431778
98DAPK20.60573685
99PRKCG0.60508340
100GRK10.60407922
101CSNK2A10.59763900
102PAK40.59400040
103CDK90.59281459
104CSF1R0.59206713
105PAK30.58965767
106DYRK1A0.58930086
107SYK0.58921286
108STK40.56933414
109PIM10.56584492
110EPHA40.56036107
111MAP3K140.55792190
112TBK10.54862004
113PIK3CA0.54167719
114* CHUK0.53712775
115BLK0.52440356
116CSNK1G10.51751575
117BRD40.51220637
118CAMKK20.51045619
119ABL10.50358028
120NME10.50031297
121ADRBK10.49680575
122KDR0.48532788
123MAP2K40.47960382
124MAPKAPK30.47498732
125MAPKAPK20.47191615
126MARK10.44927494
127PRKCQ0.44521786
128EPHA30.43808513
129GRK70.43233654
130CSNK1A10.42754284
131ATM0.42624921
132PKN10.42605409
133STK100.42300662
134NEK60.41061634
135LIMK10.39675678
136SIK20.39546834
137CAMK2A0.39392636
138RPS6KA60.39256587
139CSNK1A1L0.38407662
140LYN0.37647724
141GRK60.37542414
142RPS6KL10.37018599
143RPS6KC10.37018599

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.37716757
2Spliceosome_Homo sapiens_hsa030403.21936891
3Ribosome_Homo sapiens_hsa030103.18178574
4RNA polymerase_Homo sapiens_hsa030203.07659326
5Proteasome_Homo sapiens_hsa030503.05929955
6Mismatch repair_Homo sapiens_hsa034302.90709140
7Base excision repair_Homo sapiens_hsa034102.60994884
8Homologous recombination_Homo sapiens_hsa034402.60704831
9Nucleotide excision repair_Homo sapiens_hsa034202.25509054
10Basal transcription factors_Homo sapiens_hsa030222.23177403
11Type I diabetes mellitus_Homo sapiens_hsa049402.22413916
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22260843
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21871579
14Cell cycle_Homo sapiens_hsa041102.21077089
15Pyrimidine metabolism_Homo sapiens_hsa002402.16795863
16Fanconi anemia pathway_Homo sapiens_hsa034602.02098582
17RNA transport_Homo sapiens_hsa030132.00712294
18Protein export_Homo sapiens_hsa030601.98447583
19RNA degradation_Homo sapiens_hsa030181.90706509
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89354547
21Non-homologous end-joining_Homo sapiens_hsa034501.75078951
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53426696
23Nitrogen metabolism_Homo sapiens_hsa009101.50720411
24p53 signaling pathway_Homo sapiens_hsa041151.47158938
25Collecting duct acid secretion_Homo sapiens_hsa049661.46402449
26Caffeine metabolism_Homo sapiens_hsa002321.39924086
27mRNA surveillance pathway_Homo sapiens_hsa030151.35421211
28Nicotine addiction_Homo sapiens_hsa050331.34984286
29Butanoate metabolism_Homo sapiens_hsa006501.34341437
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33031891
31Propanoate metabolism_Homo sapiens_hsa006401.32355634
32Purine metabolism_Homo sapiens_hsa002301.31371360
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30335158
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28051903
35Herpes simplex infection_Homo sapiens_hsa051681.27879290
36Epstein-Barr virus infection_Homo sapiens_hsa051691.18598257
37Olfactory transduction_Homo sapiens_hsa047401.16748236
38Allograft rejection_Homo sapiens_hsa053301.15609554
39Primary immunodeficiency_Homo sapiens_hsa053401.12407182
40Asthma_Homo sapiens_hsa053101.11920973
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.11717973
42Peroxisome_Homo sapiens_hsa041461.11208473
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09284109
44Alzheimers disease_Homo sapiens_hsa050101.09045916
45Selenocompound metabolism_Homo sapiens_hsa004501.07679409
46Fatty acid elongation_Homo sapiens_hsa000621.06824532
47Legionellosis_Homo sapiens_hsa051341.05414623
48Phototransduction_Homo sapiens_hsa047441.04831711
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02816610
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02618283
51Arachidonic acid metabolism_Homo sapiens_hsa005901.01734102
52* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98788810
53Measles_Homo sapiens_hsa051620.96115230
54Autoimmune thyroid disease_Homo sapiens_hsa053200.95318854
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.93840599
56Antigen processing and presentation_Homo sapiens_hsa046120.92032573
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90762027
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90731874
59Hematopoietic cell lineage_Homo sapiens_hsa046400.89594657
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85217604
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84473986
62Leishmaniasis_Homo sapiens_hsa051400.84238602
63Tryptophan metabolism_Homo sapiens_hsa003800.83965589
64GABAergic synapse_Homo sapiens_hsa047270.83635480
65Taste transduction_Homo sapiens_hsa047420.83025307
66HTLV-I infection_Homo sapiens_hsa051660.81762772
67Graft-versus-host disease_Homo sapiens_hsa053320.81337909
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78342971
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78143576
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77783964
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77662352
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76648419
73Morphine addiction_Homo sapiens_hsa050320.74456556
74* Systemic lupus erythematosus_Homo sapiens_hsa053220.74157815
75Viral carcinogenesis_Homo sapiens_hsa052030.73376607
76Viral myocarditis_Homo sapiens_hsa054160.73264402
77Staphylococcus aureus infection_Homo sapiens_hsa051500.72946272
78One carbon pool by folate_Homo sapiens_hsa006700.71406906
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70715104
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68439629
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.67376229
82Shigellosis_Homo sapiens_hsa051310.66613172
83Notch signaling pathway_Homo sapiens_hsa043300.66207588
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65351190
85Sphingolipid metabolism_Homo sapiens_hsa006000.64973644
86Influenza A_Homo sapiens_hsa051640.64218627
87Apoptosis_Homo sapiens_hsa042100.63361330
88Hepatitis B_Homo sapiens_hsa051610.62417372
89Synaptic vesicle cycle_Homo sapiens_hsa047210.61119543
90Basal cell carcinoma_Homo sapiens_hsa052170.58997813
91Chemical carcinogenesis_Homo sapiens_hsa052040.58439994
92Huntingtons disease_Homo sapiens_hsa050160.58023590
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57188318
94N-Glycan biosynthesis_Homo sapiens_hsa005100.55416286
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54488158
96Small cell lung cancer_Homo sapiens_hsa052220.54195247
97Circadian entrainment_Homo sapiens_hsa047130.52932602
98Cardiac muscle contraction_Homo sapiens_hsa042600.52860803
99Malaria_Homo sapiens_hsa051440.52256547
100Pertussis_Homo sapiens_hsa051330.51591531
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50398079
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.50325666
103MicroRNAs in cancer_Homo sapiens_hsa052060.50161652
104Parkinsons disease_Homo sapiens_hsa050120.49345024
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49319397
106Metabolic pathways_Homo sapiens_hsa011000.48941900
107TGF-beta signaling pathway_Homo sapiens_hsa043500.47751591
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45846439
109Hedgehog signaling pathway_Homo sapiens_hsa043400.44720955
110Hippo signaling pathway_Homo sapiens_hsa043900.44684130
111Serotonergic synapse_Homo sapiens_hsa047260.43928739
112Glutathione metabolism_Homo sapiens_hsa004800.43608095
113Linoleic acid metabolism_Homo sapiens_hsa005910.43019070
114TNF signaling pathway_Homo sapiens_hsa046680.42567302
115Colorectal cancer_Homo sapiens_hsa052100.42497531
116Pathways in cancer_Homo sapiens_hsa052000.41724182
117Rheumatoid arthritis_Homo sapiens_hsa053230.40449288
118Salmonella infection_Homo sapiens_hsa051320.40241958
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.38123558
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37945075
121Oocyte meiosis_Homo sapiens_hsa041140.37694078
122Ether lipid metabolism_Homo sapiens_hsa005650.37596930
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37580118
124Salivary secretion_Homo sapiens_hsa049700.37128865
125Phagosome_Homo sapiens_hsa041450.37125791
126Dopaminergic synapse_Homo sapiens_hsa047280.36702708
127* Alcoholism_Homo sapiens_hsa050340.36527081
128Toxoplasmosis_Homo sapiens_hsa051450.35955664
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35597280
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35501398
131beta-Alanine metabolism_Homo sapiens_hsa004100.34971524
132T cell receptor signaling pathway_Homo sapiens_hsa046600.34803143
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.33625359
134Thyroid cancer_Homo sapiens_hsa052160.33067694
135Hepatitis C_Homo sapiens_hsa051600.31788179
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.30957897
137Circadian rhythm_Homo sapiens_hsa047100.30877983
138Oxidative phosphorylation_Homo sapiens_hsa001900.29649490
139Folate biosynthesis_Homo sapiens_hsa007900.28950616
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28203865
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28015110
142Osteoclast differentiation_Homo sapiens_hsa043800.27771659
143Regulation of autophagy_Homo sapiens_hsa041400.27279295
144Prostate cancer_Homo sapiens_hsa052150.26906540

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