H3F3AP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.37225251
2behavioral response to nicotine (GO:0035095)5.27143385
3pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.24686063
4chaperone-mediated protein transport (GO:0072321)4.67678708
5ribosomal small subunit assembly (GO:0000028)4.59551357
6pyrimidine nucleotide catabolic process (GO:0006244)4.49851908
7pyrimidine nucleobase catabolic process (GO:0006208)4.42719472
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.29581053
9NADH dehydrogenase complex assembly (GO:0010257)4.29581053
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.29581053
11protein complex biogenesis (GO:0070271)4.29456705
12viral transcription (GO:0019083)3.99474613
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83959874
14ATP synthesis coupled proton transport (GO:0015986)3.83959874
15mitochondrial respiratory chain complex assembly (GO:0033108)3.82179437
16pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.79620965
17translational termination (GO:0006415)3.77441642
18base-excision repair, AP site formation (GO:0006285)3.76721582
19DNA deamination (GO:0045006)3.74872939
20deoxyribonucleotide catabolic process (GO:0009264)3.62825434
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54517739
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54517739
23substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.47951094
24substrate-independent telencephalic tangential migration (GO:0021826)3.47951094
25ribosomal small subunit biogenesis (GO:0042274)3.43332509
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43237549
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39938982
28nucleobase catabolic process (GO:0046113)3.32772533
29translational elongation (GO:0006414)3.32611169
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.31579347
31regulation of cilium movement (GO:0003352)3.31036874
32negative regulation of response to food (GO:0032096)3.29601869
33negative regulation of appetite (GO:0032099)3.29601869
34protein polyglutamylation (GO:0018095)3.28793825
35deoxyribose phosphate catabolic process (GO:0046386)3.26612349
36cell proliferation in forebrain (GO:0021846)3.25230132
37positive regulation of T cell apoptotic process (GO:0070234)3.23529096
38negative regulation of telomere maintenance (GO:0032205)3.23396819
39electron transport chain (GO:0022900)3.22667613
40respiratory electron transport chain (GO:0022904)3.20536811
41negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.18518637
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12508843
43GTP biosynthetic process (GO:0006183)3.08875989
44metallo-sulfur cluster assembly (GO:0031163)3.08797924
45iron-sulfur cluster assembly (GO:0016226)3.08797924
46cotranslational protein targeting to membrane (GO:0006613)3.07934970
47maturation of SSU-rRNA (GO:0030490)3.06590665
48viral life cycle (GO:0019058)3.06514612
49ubiquinone biosynthetic process (GO:0006744)3.05688480
50protein targeting to ER (GO:0045047)3.05029598
51amine catabolic process (GO:0009310)3.04551282
52cellular biogenic amine catabolic process (GO:0042402)3.04551282
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03161260
54seminiferous tubule development (GO:0072520)3.02680491
55sequestering of actin monomers (GO:0042989)3.02609284
56protein-cofactor linkage (GO:0018065)2.98496127
57cellular protein complex disassembly (GO:0043624)2.97930364
58protein localization to endoplasmic reticulum (GO:0070972)2.97873184
59platelet dense granule organization (GO:0060155)2.97124291
60establishment of protein localization to endoplasmic reticulum (GO:0072599)2.88649870
61positive regulation of protein homooligomerization (GO:0032464)2.86298391
62pyrimidine-containing compound catabolic process (GO:0072529)2.80685075
63establishment of mitochondrion localization (GO:0051654)2.77850437
64ubiquinone metabolic process (GO:0006743)2.76411396
65lysosome localization (GO:0032418)2.72114358
66protein complex disassembly (GO:0043241)2.71338595
67arginine catabolic process (GO:0006527)2.69651107
68negative regulation of heart rate (GO:0010459)2.69205230
692-deoxyribonucleotide metabolic process (GO:0009394)2.69184530
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.68980577
71cytochrome complex assembly (GO:0017004)2.68781257
72deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.67355756
73respiratory chain complex IV assembly (GO:0008535)2.66526080
74negative regulation of transcription regulatory region DNA binding (GO:2000678)2.65112086
75hydrogen ion transmembrane transport (GO:1902600)2.59015258
76negative regulation of DNA-templated transcription, elongation (GO:0032785)2.58372967
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56827621
78macromolecular complex disassembly (GO:0032984)2.56820131
79epithelial cilium movement (GO:0003351)2.55693190
80nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54719434
81positive regulation of prostaglandin secretion (GO:0032308)2.54641149
82mitochondrial calcium ion transport (GO:0006851)2.54612775
83positive regulation of mast cell activation (GO:0033005)2.52468136
84autophagic vacuole fusion (GO:0000046)2.52400137
85neurofilament cytoskeleton organization (GO:0060052)2.51651181
86UTP biosynthetic process (GO:0006228)2.51624443
87synaptic transmission, cholinergic (GO:0007271)2.48709475
88deoxyribose phosphate metabolic process (GO:0019692)2.48530027
89CTP metabolic process (GO:0046036)2.45090820
90CTP biosynthetic process (GO:0006241)2.45090820
91intraciliary transport (GO:0042073)2.44953992
92neutrophil activation involved in immune response (GO:0002283)2.43990502
93purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.42260429
94termination of RNA polymerase III transcription (GO:0006386)2.41613067
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.41613067
96pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.40691157
97establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.39455555
98mitochondrion transport along microtubule (GO:0047497)2.39455555
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39000876
100positive regulation of lymphocyte apoptotic process (GO:0070230)2.38735952

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.73402188
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.38819191
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.49798169
4ELF1_17652178_ChIP-ChIP_JURKAT_Human2.75832866
5IRF1_19129219_ChIP-ChIP_H3396_Human2.49327215
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42408562
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.40894866
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39082815
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35936941
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.20282382
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.18007931
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.15861248
13ZNF274_21170338_ChIP-Seq_K562_Hela2.07750738
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.03932028
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03158834
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.98932141
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98695417
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.90535125
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87154537
20IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75510888
21THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72298301
22EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.68375587
23BCL6_27268052_Chip-Seq_Bcells_Human1.66728865
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66033508
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65450871
26CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65384705
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64640885
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63220643
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.61710203
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60462889
31YY1_22570637_ChIP-Seq_MALME-3M_Human1.59195366
32CIITA_25753668_ChIP-Seq_RAJI_Human1.53330682
33NANOG_20526341_ChIP-Seq_ESCs_Human1.52261755
34GABP_19822575_ChIP-Seq_HepG2_Human1.51755990
35RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50124899
36CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50092865
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48454292
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.48236939
39FOXP3_21729870_ChIP-Seq_TREG_Human1.47329251
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46922372
41VDR_23849224_ChIP-Seq_CD4+_Human1.45576185
42ERA_21632823_ChIP-Seq_H3396_Human1.43042588
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39468558
44REST_21632747_ChIP-Seq_MESCs_Mouse1.36112928
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35636433
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35032427
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.34386179
48TP53_22573176_ChIP-Seq_HFKS_Human1.33695676
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31498908
50E2F1_20622854_ChIP-Seq_HELA_Human1.31430572
51SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30487132
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28529301
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28221322
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27851646
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.27526169
56P68_20966046_ChIP-Seq_HELA_Human1.26774628
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25733217
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.24861846
59TAF2_19829295_ChIP-Seq_ESCs_Human1.20436485
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.19880081
61P300_27268052_Chip-Seq_Bcells_Human1.18610522
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18032249
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17904308
64BCOR_27268052_Chip-Seq_Bcells_Human1.16391777
65PHF8_20622854_ChIP-Seq_HELA_Human1.14801178
66CTCF_20526341_ChIP-Seq_ESCs_Human1.14192525
67MYC_18940864_ChIP-ChIP_HL60_Human1.13915903
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13593323
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12528573
70SA1_27219007_Chip-Seq_Bcells_Human1.12422061
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10012241
72STAT1_20625510_ChIP-Seq_HELA_Human1.09903891
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08903266
74XRN2_22483619_ChIP-Seq_HELA_Human1.04994365
75CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04811052
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04298645
77FOXP1_21924763_ChIP-Seq_HESCs_Human1.03756389
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03532881
79CTCF_27219007_Chip-Seq_Bcells_Human1.02092016
80TTF2_22483619_ChIP-Seq_HELA_Human1.00967545
81VDR_22108803_ChIP-Seq_LS180_Human1.00939217
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00149095
83MYC_19829295_ChIP-Seq_ESCs_Human0.99210295
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98718516
85MYC_18555785_ChIP-Seq_MESCs_Mouse0.97694994
86SPI1_20517297_ChIP-Seq_HL60_Human0.97225079
87RAC3_21632823_ChIP-Seq_H3396_Human0.93923208
88SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93581813
89OCT4_19829295_ChIP-Seq_ESCs_Human0.93071361
90SOX2_21211035_ChIP-Seq_LN229_Human0.91652137
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90671308
92NCOR_22424771_ChIP-Seq_293T_Human0.90515141
93CTCF_26484167_Chip-Seq_Bcells_Mouse0.90170875
94P53_21459846_ChIP-Seq_SAOS-2_Human0.89149244
95VDR_21846776_ChIP-Seq_THP-1_Human0.88865963
96EZH2_27294783_Chip-Seq_ESCs_Mouse0.87875403
97CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87513512
98UTX_26944678_Chip-Seq_JUKART_Human0.87411264
99OCT4_20526341_ChIP-Seq_ESCs_Human0.86182297
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85426912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.25064882
2MP0003787_abnormal_imprinting4.00216909
3MP0002653_abnormal_ependyma_morphology3.72143307
4MP0008877_abnormal_DNA_methylation2.92722368
5MP0008789_abnormal_olfactory_epithelium2.75576482
6MP0006276_abnormal_autonomic_nervous2.65320221
7MP0003122_maternal_imprinting2.63095893
8MP0005394_taste/olfaction_phenotype2.55298566
9MP0005499_abnormal_olfactory_system2.55298566
10MP0009379_abnormal_foot_pigmentation2.51774104
11MP0003121_genomic_imprinting2.38448268
12MP0005464_abnormal_platelet_physiology2.10778982
13MP0005084_abnormal_gallbladder_morpholo2.02390194
14MP0004142_abnormal_muscle_tone1.98299742
15MP0001529_abnormal_vocalization1.77035663
16MP0001968_abnormal_touch/_nociception1.76346881
17MP0003011_delayed_dark_adaptation1.74505838
18MP0003880_abnormal_central_pattern1.73294464
19MP0002163_abnormal_gland_morphology1.68326103
20MP0003123_paternal_imprinting1.61243442
21MP0002132_abnormal_respiratory_system1.55851716
22MP0005671_abnormal_response_to1.54808237
23MP0005645_abnormal_hypothalamus_physiol1.53081518
24MP0001986_abnormal_taste_sensitivity1.53033383
25MP0002736_abnormal_nociception_after1.50022939
26MP0001905_abnormal_dopamine_level1.48546715
27MP0002733_abnormal_thermal_nociception1.43316240
28MP0002102_abnormal_ear_morphology1.41706478
29MP0008872_abnormal_physiological_respon1.37630126
30MP0002876_abnormal_thyroid_physiology1.33157249
31MP0004147_increased_porphyrin_level1.32546709
32MP0001485_abnormal_pinna_reflex1.32402791
33MP0001970_abnormal_pain_threshold1.29089739
34MP0003724_increased_susceptibility_to1.28960117
35MP0001835_abnormal_antigen_presentation1.24799334
36MP0000778_abnormal_nervous_system1.24077789
37MP0003646_muscle_fatigue1.23587963
38MP0005646_abnormal_pituitary_gland1.22589094
39MP0005551_abnormal_eye_electrophysiolog1.22277324
40MP0002638_abnormal_pupillary_reflex1.18490407
41MP0003878_abnormal_ear_physiology1.18080566
42MP0005377_hearing/vestibular/ear_phenot1.18080566
43MP0002272_abnormal_nervous_system1.14947092
44MP0005423_abnormal_somatic_nervous1.14662139
45MP0008995_early_reproductive_senescence1.12620280
46MP0003186_abnormal_redox_activity1.11284765
47MP0004133_heterotaxia1.09343497
48MP0002557_abnormal_social/conspecific_i1.07920960
49MP0008058_abnormal_DNA_repair1.07346189
50MP0002822_catalepsy1.04291562
51MP0000631_abnormal_neuroendocrine_gland1.03827825
52MP0001919_abnormal_reproductive_system1.01517121
53MP0009764_decreased_sensitivity_to1.00651718
54MP0005083_abnormal_biliary_tract1.00172391
55MP0002735_abnormal_chemical_nociception0.99950459
56MP0001984_abnormal_olfaction0.99729540
57MP0001293_anophthalmia0.99642456
58MP0001663_abnormal_digestive_system0.99264178
59MP0001800_abnormal_humoral_immune0.99021662
60MP0006036_abnormal_mitochondrial_physio0.98452875
61MP0000372_irregular_coat_pigmentation0.96132760
62MP0004742_abnormal_vestibular_system0.94959047
63MP0000230_abnormal_systemic_arterial0.92120948
64MP0005389_reproductive_system_phenotype0.92090066
65MP0005025_abnormal_response_to0.90999908
66MP0003718_maternal_effect0.90313083
67MP0006035_abnormal_mitochondrial_morpho0.89837041
68MP0002095_abnormal_skin_pigmentation0.89603104
69MP0002752_abnormal_somatic_nervous0.89112204
70MP0002723_abnormal_immune_serum0.87916654
71MP0009046_muscle_twitch0.87399101
72MP0009745_abnormal_behavioral_response0.87181360
73MP0005387_immune_system_phenotype0.86836885
74MP0001790_abnormal_immune_system0.86836885
75MP0002420_abnormal_adaptive_immunity0.85743289
76MP0005410_abnormal_fertilization0.84687652
77MP0002067_abnormal_sensory_capabilities0.83960710
78MP0001819_abnormal_immune_cell0.83658664
79MP0000465_gastrointestinal_hemorrhage0.82776689
80MP0002277_abnormal_respiratory_mucosa0.82740636
81MP0003879_abnormal_hair_cell0.82188120
82MP0002210_abnormal_sex_determination0.81826442
83MP0005075_abnormal_melanosome_morpholog0.81795026
84MP0000955_abnormal_spinal_cord0.81318669
85MP0009278_abnormal_bone_marrow0.80320193
86MP0006072_abnormal_retinal_apoptosis0.79951854
87MP0009765_abnormal_xenobiotic_induced0.79926715
88MP0000049_abnormal_middle_ear0.79724251
89MP0008875_abnormal_xenobiotic_pharmacok0.79465417
90MP0004859_abnormal_synaptic_plasticity0.79415369
91MP0002160_abnormal_reproductive_system0.78980261
92MP0003635_abnormal_synaptic_transmissio0.78684897
93MP0002572_abnormal_emotion/affect_behav0.77777655
94MP0002452_abnormal_antigen_presenting0.77727802
95MP0003866_abnormal_defecation0.77680857
96MP0002148_abnormal_hypersensitivity_rea0.77339072
97MP0005195_abnormal_posterior_eye0.75443739
98MP0003938_abnormal_ear_development0.73355019
99MP0001119_abnormal_female_reproductive0.71835462
100MP0000689_abnormal_spleen_morphology0.71709390

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.92013253
2Abnormal mitochondria in muscle tissue (HP:0008316)3.72032800
3Acute encephalopathy (HP:0006846)3.62878659
4Mitochondrial inheritance (HP:0001427)3.57754165
5Reticulocytopenia (HP:0001896)3.23840878
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.18882898
7Hepatocellular necrosis (HP:0001404)3.16623842
8Polyphagia (HP:0002591)3.13417521
9Petechiae (HP:0000967)3.09912793
10Increased CSF lactate (HP:0002490)3.02154124
11Progressive macrocephaly (HP:0004481)3.02023194
12Abnormality of the labia minora (HP:0012880)2.92749055
13Abnormality of the heme biosynthetic pathway (HP:0010472)2.92524788
14Abnormality of midbrain morphology (HP:0002418)2.88142970
15Molar tooth sign on MRI (HP:0002419)2.88142970
163-Methylglutaconic aciduria (HP:0003535)2.85746076
17Pancreatic fibrosis (HP:0100732)2.84868761
18Prolonged bleeding time (HP:0003010)2.83280544
19Hepatic necrosis (HP:0002605)2.81089605
20Abnormality of cells of the erythroid lineage (HP:0012130)2.75086301
21Myokymia (HP:0002411)2.72638377
22Pancreatic cysts (HP:0001737)2.61040675
23Abnormal rod and cone electroretinograms (HP:0008323)2.59206408
24Stomatitis (HP:0010280)2.56951119
25Increased IgM level (HP:0003496)2.55575024
26Renal Fanconi syndrome (HP:0001994)2.52890707
27Abnormal number of erythroid precursors (HP:0012131)2.50933265
28Elevated erythrocyte sedimentation rate (HP:0003565)2.49774576
29Hyperglycinemia (HP:0002154)2.45675796
30Agitation (HP:0000713)2.41007008
31Lissencephaly (HP:0001339)2.39379626
32True hermaphroditism (HP:0010459)2.37947930
33Lipid accumulation in hepatocytes (HP:0006561)2.37848722
34Hyperthyroidism (HP:0000836)2.37161654
35Medial flaring of the eyebrow (HP:0010747)2.36091871
36Rib fusion (HP:0000902)2.35132766
37Aplasia/Hypoplasia of the spleen (HP:0010451)2.35121443
38Cerebral edema (HP:0002181)2.32192116
39Increased intramyocellular lipid droplets (HP:0012240)2.31179895
40Nephronophthisis (HP:0000090)2.26961729
41Optic disc pallor (HP:0000543)2.26884207
42Increased hepatocellular lipid droplets (HP:0006565)2.25855331
43Asplenia (HP:0001746)2.25022576
44Abolished electroretinogram (ERG) (HP:0000550)2.20964159
45Purpura (HP:0000979)2.20714190
46Severe visual impairment (HP:0001141)2.20075038
47Pendular nystagmus (HP:0012043)2.19805109
48Pachygyria (HP:0001302)2.18390548
49Type 2 muscle fiber atrophy (HP:0003554)2.13703651
50Failure to thrive in infancy (HP:0001531)2.12443479
51Increased muscle lipid content (HP:0009058)2.11057393
52Lactic acidosis (HP:0003128)2.10724764
53Sclerocornea (HP:0000647)2.08618142
54Muscle fiber atrophy (HP:0100295)2.06662256
55Absent thumb (HP:0009777)2.04361574
56Pallor (HP:0000980)2.03272290
57Gait imbalance (HP:0002141)1.99359342
58Anomalous pulmonary venous return (HP:0010772)1.98496081
59Growth hormone deficiency (HP:0000824)1.97733196
60Increased serum lactate (HP:0002151)1.97699634
61Poor suck (HP:0002033)1.97583336
62Optic nerve coloboma (HP:0000588)1.97027577
63Abnormal hair whorl (HP:0010721)1.96893746
64Type II lissencephaly (HP:0007260)1.94273406
65Anencephaly (HP:0002323)1.94120342
66Colon cancer (HP:0003003)1.92003316
67Adrenal hypoplasia (HP:0000835)1.91057592
68Congenital stationary night blindness (HP:0007642)1.90995388
69Congenital primary aphakia (HP:0007707)1.87809260
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86357300
71Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85544741
72Obstructive lung disease (HP:0006536)1.85184241
73Chronic obstructive pulmonary disease (HP:0006510)1.85184241
74Abnormality of renal resorption (HP:0011038)1.84783741
75Bony spicule pigmentary retinopathy (HP:0007737)1.84419025
76Exertional dyspnea (HP:0002875)1.83962369
77Aplastic anemia (HP:0001915)1.82802206
78Decreased central vision (HP:0007663)1.82503624
79Horseshoe kidney (HP:0000085)1.81454814
80Nephrogenic diabetes insipidus (HP:0009806)1.80635947
81Neutropenia (HP:0001875)1.80039571
82Pancytopenia (HP:0001876)1.80035374
83Thyroid-stimulating hormone excess (HP:0002925)1.78947712
84Cerebral palsy (HP:0100021)1.77943925
85Macrocytic anemia (HP:0001972)1.74711300
86Abnormality of the renal medulla (HP:0100957)1.72438240
87Respiratory failure (HP:0002878)1.71958005
88Exercise intolerance (HP:0003546)1.70734099
89Abnormality of DNA repair (HP:0003254)1.69477966
90Oligomenorrhea (HP:0000876)1.67753647
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67198929
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67198929
93Abnormal respiratory epithelium morphology (HP:0012253)1.67114790
94Abnormal respiratory motile cilium morphology (HP:0005938)1.67114790
95Retinal dysplasia (HP:0007973)1.64539348
96Abnormality of magnesium homeostasis (HP:0004921)1.64464012
97Hypochromic microcytic anemia (HP:0004840)1.63646154
98Lethargy (HP:0001254)1.63564448
99Retinitis pigmentosa (HP:0000510)1.62581047
100Progressive microcephaly (HP:0000253)1.62288061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.33811340
2MAP3K112.98326414
3DYRK22.95831151
4TAOK32.85623445
5CDK192.80948006
6TESK22.64036258
7MAP4K22.61334669
8STK162.47115698
9VRK22.28710467
10ZAK2.23553691
11NUAK12.17424179
12MAP4K12.04764607
13TXK2.01377829
14ADRBK21.96433510
15MAP2K71.71643135
16TLK11.63749765
17WNK31.57473122
18BTK1.51992861
19KDR1.47195726
20TNK21.46541673
21MAPK131.42954492
22MINK11.40315603
23PIM21.39172183
24DYRK31.32376155
25DYRK1B1.28372285
26FES1.27766361
27AURKA1.24883805
28WNK41.14206851
29SYK1.12412168
30GRK11.09568441
31CASK1.09484991
32VRK11.06119892
33PINK11.05409868
34GRK61.05249278
35CDC71.04134573
36LRRK21.03878979
37LIMK10.98409370
38SIK20.96636507
39BMPR1B0.95614832
40CSNK1G30.95513984
41PRKCQ0.94567873
42CSNK1G20.93778933
43MARK10.88239455
44TEC0.86387518
45ARAF0.85679885
46MAP3K40.81950102
47PRKCG0.81840836
48PKN10.81041555
49LYN0.79084997
50MARK20.77044554
51PAK10.75634212
52ADRBK10.74648889
53PRKCH0.73431757
54IRAK40.71370103
55ITK0.70822251
56PAK30.69894907
57CAMK10.69855387
58IKBKB0.69542187
59CSNK1G10.66556084
60OXSR10.66375020
61TESK10.66361694
62GRK50.66047895
63ABL20.65716696
64CSF1R0.65169191
65ATR0.64310251
66MARK30.62067749
67MATK0.61409111
68TRIM280.58963859
69CSK0.58801597
70INSRR0.58696640
71LCK0.55484969
72PRKCZ0.55389711
73DAPK30.55321460
74CAMKK10.54764532
75PRKCD0.54669431
76PLK10.53309260
77STK110.52618069
78CSNK1A1L0.52185097
79PRKACA0.51456502
80RPS6KA50.49575017
81PIM10.47665520
82DAPK10.46805094
83NTRK20.45722915
84BRAF0.44839127
85BMX0.44432207
86DAPK20.44114886
87TIE10.43816784
88MAP2K40.43446621
89CSNK2A20.43339408
90KIT0.41477952
91PRKCI0.41389079
92HCK0.41172588
93EPHB20.40467815
94DYRK1A0.40344477
95PASK0.39842929
96CDK140.38862035
97ZAP700.38379365
98PRKCA0.38221287
99CSNK1A10.37579491
100FGR0.37422249

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.26114229
2Ribosome_Homo sapiens_hsa030104.03901139
3Parkinsons disease_Homo sapiens_hsa050124.03001435
4Huntingtons disease_Homo sapiens_hsa050162.63088339
5RNA polymerase_Homo sapiens_hsa030202.58110210
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.31725631
7Alzheimers disease_Homo sapiens_hsa050102.30272644
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27796008
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.27766477
10Cardiac muscle contraction_Homo sapiens_hsa042602.22336287
11Primary immunodeficiency_Homo sapiens_hsa053402.06706211
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88398789
13Proteasome_Homo sapiens_hsa030501.72877110
14Base excision repair_Homo sapiens_hsa034101.71263539
15Pyrimidine metabolism_Homo sapiens_hsa002401.69967057
16Linoleic acid metabolism_Homo sapiens_hsa005911.64118777
17Phototransduction_Homo sapiens_hsa047441.57490066
18Fanconi anemia pathway_Homo sapiens_hsa034601.56317701
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48700216
20Sulfur relay system_Homo sapiens_hsa041221.46741552
21Homologous recombination_Homo sapiens_hsa034401.44589228
22DNA replication_Homo sapiens_hsa030301.42422389
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42110144
24Mismatch repair_Homo sapiens_hsa034301.38853479
25Fatty acid elongation_Homo sapiens_hsa000621.36383683
26Collecting duct acid secretion_Homo sapiens_hsa049661.34968090
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33459931
28Allograft rejection_Homo sapiens_hsa053301.31309968
29Arachidonic acid metabolism_Homo sapiens_hsa005901.31178394
30Autoimmune thyroid disease_Homo sapiens_hsa053201.26421043
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26139944
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25332726
33Peroxisome_Homo sapiens_hsa041461.25302191
34Graft-versus-host disease_Homo sapiens_hsa053321.22623108
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19168832
36Regulation of autophagy_Homo sapiens_hsa041401.16937163
37Asthma_Homo sapiens_hsa053101.16492024
38Steroid biosynthesis_Homo sapiens_hsa001001.15741361
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15114485
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11135916
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05593206
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.00914891
43Ether lipid metabolism_Homo sapiens_hsa005650.96691835
44Type I diabetes mellitus_Homo sapiens_hsa049400.94694557
45Butanoate metabolism_Homo sapiens_hsa006500.90693655
46Basal transcription factors_Homo sapiens_hsa030220.90423855
47Protein export_Homo sapiens_hsa030600.88836035
48Purine metabolism_Homo sapiens_hsa002300.87778709
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86229723
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84268641
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84161621
52Nicotine addiction_Homo sapiens_hsa050330.83404350
53Olfactory transduction_Homo sapiens_hsa047400.83218046
54RNA degradation_Homo sapiens_hsa030180.82759859
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82089389
56Systemic lupus erythematosus_Homo sapiens_hsa053220.80980505
57Hematopoietic cell lineage_Homo sapiens_hsa046400.80721831
58Metabolic pathways_Homo sapiens_hsa011000.78045130
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77788957
60Alcoholism_Homo sapiens_hsa050340.75998383
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75161217
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74978211
63Caffeine metabolism_Homo sapiens_hsa002320.73562393
64Folate biosynthesis_Homo sapiens_hsa007900.71552123
65Synaptic vesicle cycle_Homo sapiens_hsa047210.67746986
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65423864
67Morphine addiction_Homo sapiens_hsa050320.63553823
68Fat digestion and absorption_Homo sapiens_hsa049750.63142942
69Glutathione metabolism_Homo sapiens_hsa004800.60419185
70Tryptophan metabolism_Homo sapiens_hsa003800.59555499
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55702607
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55653299
73Platelet activation_Homo sapiens_hsa046110.55248577
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54999612
75Viral myocarditis_Homo sapiens_hsa054160.54726022
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.53048322
77Serotonergic synapse_Homo sapiens_hsa047260.51883908
78Nucleotide excision repair_Homo sapiens_hsa034200.51621746
79Propanoate metabolism_Homo sapiens_hsa006400.50117244
80Phagosome_Homo sapiens_hsa041450.50081355
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.49521210
82Nitrogen metabolism_Homo sapiens_hsa009100.49199222
83Chemical carcinogenesis_Homo sapiens_hsa052040.48026620
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46605317
85Chemokine signaling pathway_Homo sapiens_hsa040620.45807567
86GABAergic synapse_Homo sapiens_hsa047270.43673769
87Rheumatoid arthritis_Homo sapiens_hsa053230.42995926
88Antigen processing and presentation_Homo sapiens_hsa046120.42900541
89Staphylococcus aureus infection_Homo sapiens_hsa051500.42384036
90One carbon pool by folate_Homo sapiens_hsa006700.41632978
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.40996908
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40256512
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39675453
94Glycerolipid metabolism_Homo sapiens_hsa005610.39281210
95Retinol metabolism_Homo sapiens_hsa008300.39105575
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36702227
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.36654499
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31924023
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31549068
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.30598079

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