H2BFM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.68126598
2doxorubicin metabolic process (GO:0044598)8.68126598
3daunorubicin metabolic process (GO:0044597)8.68126598
4kinetochore organization (GO:0051383)6.47892389
5cell wall macromolecule catabolic process (GO:0016998)6.38968353
6cell wall macromolecule metabolic process (GO:0044036)6.38968353
7piRNA metabolic process (GO:0034587)6.30959591
8kinetochore assembly (GO:0051382)6.24538928
9cellular extravasation (GO:0045123)6.13982983
10pyrimidine nucleobase catabolic process (GO:0006208)5.95790546
11vitamin D metabolic process (GO:0042359)5.57241421
12aminoglycoside antibiotic metabolic process (GO:0030647)5.48616294
13vitamin biosynthetic process (GO:0009110)5.41372957
14cytidine metabolic process (GO:0046087)5.27078424
15cytidine catabolic process (GO:0006216)5.27078424
16cytidine deamination (GO:0009972)5.27078424
17regulation of vitamin metabolic process (GO:0030656)5.17801634
18regulation of gene expression by genetic imprinting (GO:0006349)5.08921300
19microtubule depolymerization (GO:0007019)4.88356345
20DNA methylation involved in gamete generation (GO:0043046)4.87117009
21regulation of mitotic spindle organization (GO:0060236)4.82283823
22head development (GO:0060322)4.81898577
23nucleobase catabolic process (GO:0046113)4.73829567
24substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.66365383
25substrate-independent telencephalic tangential migration (GO:0021826)4.66365383
26regulation of spindle organization (GO:0090224)4.63808635
27metaphase plate congression (GO:0051310)4.61566103
28presynaptic membrane organization (GO:0097090)4.60606036
29behavioral response to nicotine (GO:0035095)4.59572780
30regulation of sister chromatid cohesion (GO:0007063)4.53448106
31presynaptic membrane assembly (GO:0097105)4.50023669
32atrial cardiac muscle cell action potential (GO:0086014)4.47956166
33chromatin remodeling at centromere (GO:0031055)4.44015425
34CENP-A containing nucleosome assembly (GO:0034080)4.43260054
35mitotic sister chromatid segregation (GO:0000070)4.40067166
36polyol biosynthetic process (GO:0046173)4.37426839
37protein localization to chromosome, centromeric region (GO:0071459)4.33828223
38sister chromatid segregation (GO:0000819)4.22952105
39olfactory bulb development (GO:0021772)4.20847732
40DNA integration (GO:0015074)4.19974361
41protein localization to kinetochore (GO:0034501)4.19571009
42negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.16844376
43postsynaptic membrane organization (GO:0001941)4.16366978
44meiotic chromosome segregation (GO:0045132)4.13421327
45ribosomal small subunit assembly (GO:0000028)4.02097996
46mitotic chromosome condensation (GO:0007076)4.00956090
47forebrain neuron differentiation (GO:0021879)3.97451533
48negative regulation of epidermal cell differentiation (GO:0045605)3.96203056
49meiotic cell cycle (GO:0051321)3.90826723
50regulation of respiratory burst (GO:0060263)3.89788124
51S-adenosylmethionine metabolic process (GO:0046500)3.87630423
52regulation of mitochondrial translation (GO:0070129)3.84025497
53pyrimidine ribonucleoside catabolic process (GO:0046133)3.78861075
54cerebral cortex radially oriented cell migration (GO:0021799)3.78210064
55chromosome organization involved in meiosis (GO:0070192)3.75277263
56somite development (GO:0061053)3.65681611
57axonal fasciculation (GO:0007413)3.64615980
58genetic imprinting (GO:0071514)3.64606200
59mitotic metaphase plate congression (GO:0007080)3.63022772
60histone exchange (GO:0043486)3.62753153
61neuron cell-cell adhesion (GO:0007158)3.62462536
62neuron recognition (GO:0008038)3.58722671
63retinal ganglion cell axon guidance (GO:0031290)3.58002985
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.57647681
65NADH dehydrogenase complex assembly (GO:0010257)3.57647681
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57647681
67positive regulation of digestive system process (GO:0060456)3.55437641
68central nervous system projection neuron axonogenesis (GO:0021952)3.55252179
69attachment of spindle microtubules to kinetochore (GO:0008608)3.55238111
70L-methionine salvage (GO:0071267)3.54925235
71L-methionine biosynthetic process (GO:0071265)3.54925235
72amino acid salvage (GO:0043102)3.54925235
73response to pheromone (GO:0019236)3.54896364
74regulation of hydrogen peroxide metabolic process (GO:0010310)3.54850222
75male meiosis (GO:0007140)3.53798796
76chromosome segregation (GO:0007059)3.53413187
77meiotic nuclear division (GO:0007126)3.51176303
78neurotransmitter-gated ion channel clustering (GO:0072578)3.48961177
79regulation of meiosis I (GO:0060631)3.44851251
80DNA replication-independent nucleosome organization (GO:0034724)3.42689504
81DNA replication-independent nucleosome assembly (GO:0006336)3.42689504
82tachykinin receptor signaling pathway (GO:0007217)3.42610238
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.41446844
84response to UV-C (GO:0010225)3.40212730
85positive regulation of chemokine secretion (GO:0090197)3.39149002
86fat-soluble vitamin catabolic process (GO:0042363)3.36295731
87vitamin catabolic process (GO:0009111)3.36295731
88establishment of mitochondrion localization (GO:0051654)3.35964220
89pre-miRNA processing (GO:0031054)3.34661412
90protein localization to synapse (GO:0035418)3.33628419
91short-term memory (GO:0007614)3.29621227
92intraciliary transport (GO:0042073)3.29181198
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.28099367
94transmission of nerve impulse (GO:0019226)3.27894185
95synapsis (GO:0007129)3.25119806
96establishment of chromosome localization (GO:0051303)3.25025379
97regulation of timing of cell differentiation (GO:0048505)3.23622145
98cornea development in camera-type eye (GO:0061303)3.23443801
99regulation of development, heterochronic (GO:0040034)3.21279268
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20049337
101positive regulation of mitochondrial fission (GO:0090141)3.18846875
102limb bud formation (GO:0060174)3.18503505
103potassium ion export (GO:0071435)3.18435255
104nucleotide-sugar biosynthetic process (GO:0009226)3.14555788
105calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.13974496
106negative regulation of translation, ncRNA-mediated (GO:0040033)3.13349971
107regulation of translation, ncRNA-mediated (GO:0045974)3.13349971
108negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.13349971
109behavioral response to ethanol (GO:0048149)3.11913623
110regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.10488016
111negative regulation of glial cell proliferation (GO:0060253)3.09259782
112protein complex biogenesis (GO:0070271)3.07412494
113epithelial cilium movement (GO:0003351)3.06349913
114regulation of cilium movement (GO:0003352)3.06273767
115negative regulation of transcription regulatory region DNA binding (GO:2000678)3.04603780
116synaptonemal complex assembly (GO:0007130)3.04549341
117nonmotile primary cilium assembly (GO:0035058)3.04500945
118DNA methylation (GO:0006306)3.03036591
119DNA alkylation (GO:0006305)3.03036591
120neuron fate determination (GO:0048664)3.02813801
121axoneme assembly (GO:0035082)3.00749725
122spinal cord development (GO:0021510)2.99738628
123negative regulation of cytokine biosynthetic process (GO:0042036)2.99500434
124negative regulation of epidermis development (GO:0045683)2.99345724
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98443114
126regulation of action potential (GO:0098900)2.97658908
127negative regulation of oligodendrocyte differentiation (GO:0048715)2.97408118
128male meiosis I (GO:0007141)2.94803054
129locomotory exploration behavior (GO:0035641)2.91338878
130chromatin assembly or disassembly (GO:0006333)2.90574455
131sequestering of actin monomers (GO:0042989)2.90495740
132regulation of helicase activity (GO:0051095)2.89980260
133regulation of retinoic acid receptor signaling pathway (GO:0048385)2.89875317
134central nervous system neuron axonogenesis (GO:0021955)2.88000669
135resolution of meiotic recombination intermediates (GO:0000712)2.87076084
136regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86981170
137chromosome condensation (GO:0030261)2.86597340
138translational termination (GO:0006415)2.86103120
139meiotic cell cycle process (GO:1903046)2.85995320
140appendage development (GO:0048736)2.84873345
141limb development (GO:0060173)2.84873345
142protein localization to cilium (GO:0061512)2.83299185
143mitochondrial respiratory chain complex assembly (GO:0033108)2.83239926
144cardiovascular system development (GO:0072358)2.82023533
145membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.81701881
146synapse assembly (GO:0007416)2.81357862
147acrosome assembly (GO:0001675)2.80961196
148chromatin assembly (GO:0031497)2.80865392
149replicative senescence (GO:0090399)2.80656409
150vocalization behavior (GO:0071625)2.78585706
151aggressive behavior (GO:0002118)2.78355966
152hindbrain development (GO:0030902)2.78292680
153dendritic spine morphogenesis (GO:0060997)2.77881835
154neuronal ion channel clustering (GO:0045161)2.75998579
155regulation of collateral sprouting (GO:0048670)2.71506942
156auditory behavior (GO:0031223)2.70934498
157cell proliferation in forebrain (GO:0021846)2.70451818
158adult walking behavior (GO:0007628)2.67724160
159mitochondrion transport along microtubule (GO:0047497)2.67408002
160establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67408002
161protein neddylation (GO:0045116)2.65557953
162regulation of non-canonical Wnt signaling pathway (GO:2000050)2.64541863
163dendrite morphogenesis (GO:0048813)2.63250516
164central nervous system myelination (GO:0022010)2.59135198
165axon ensheathment in central nervous system (GO:0032291)2.59135198
166protein-cofactor linkage (GO:0018065)2.56587070
167neural tube formation (GO:0001841)2.56302204
168negative regulation of astrocyte differentiation (GO:0048712)2.56017038
169microtubule bundle formation (GO:0001578)2.55368022
170cilium morphogenesis (GO:0060271)2.53947763
171pituitary gland development (GO:0021983)2.53918204
172protein polyglutamylation (GO:0018095)2.52685590
173cell migration in hindbrain (GO:0021535)2.51556592
174cilium organization (GO:0044782)2.51416502
175regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.51305684
176cilium assembly (GO:0042384)2.50402794
177regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.50397486
178cilium movement (GO:0003341)2.49939584
179positive regulation of synapse assembly (GO:0051965)2.48774200
180regulation of oligodendrocyte differentiation (GO:0048713)2.47879509
181detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46792494
182parturition (GO:0007567)2.46252756
183regulation of axon regeneration (GO:0048679)2.45427039
184regulation of neuron projection regeneration (GO:0070570)2.45427039
185cerebral cortex cell migration (GO:0021795)2.45341897
186glycerophospholipid catabolic process (GO:0046475)2.44603516
187ubiquinone metabolic process (GO:0006743)2.44241028
188hippocampus development (GO:0021766)2.43972667
189mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.43773116
190positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.43773116
191neuronal action potential propagation (GO:0019227)2.42239349
192behavioral defense response (GO:0002209)2.41907070
193behavioral fear response (GO:0001662)2.41907070
194negative regulation of glial cell differentiation (GO:0045686)2.41815419
195neuron migration (GO:0001764)2.40797749
196regulation of microtubule-based movement (GO:0060632)2.40356378
197ephrin receptor signaling pathway (GO:0048013)2.39279928
198fat-soluble vitamin biosynthetic process (GO:0042362)13.1132253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human8.71562791
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.54238085
3E2F7_22180533_ChIP-Seq_HELA_Human5.00082806
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.33137455
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.17850135
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.84831446
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66747304
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.61828862
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60856167
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.06396519
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83910345
12GBX2_23144817_ChIP-Seq_PC3_Human2.81322251
13ZNF274_21170338_ChIP-Seq_K562_Hela2.76741475
14AR_21909140_ChIP-Seq_LNCAP_Human2.67783460
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61008167
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50487729
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.50006397
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43110207
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.37986651
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.37370071
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.36429082
22EZH2_22144423_ChIP-Seq_EOC_Human2.28254117
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26369097
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25719772
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23228218
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23225184
27VDR_22108803_ChIP-Seq_LS180_Human2.20650280
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19012229
29FUS_26573619_Chip-Seq_HEK293_Human2.04652948
30EWS_26573619_Chip-Seq_HEK293_Human2.04356500
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01353896
32POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00696827
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98880674
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98780029
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97173949
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95724802
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.94402507
38REST_21632747_ChIP-Seq_MESCs_Mouse1.93795183
39XRN2_22483619_ChIP-Seq_HELA_Human1.92947095
40RNF2_27304074_Chip-Seq_NSC_Mouse1.92223272
41TAF15_26573619_Chip-Seq_HEK293_Human1.91918251
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89081690
43P300_19829295_ChIP-Seq_ESCs_Human1.84669712
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.82583568
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81471877
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81159964
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.79817950
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78517339
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74870370
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71520030
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69475708
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68942429
53DCP1A_22483619_ChIP-Seq_HELA_Human1.60515940
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57035002
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.51987487
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51469617
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47293715
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46763935
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.45282295
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43848229
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43150515
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43027751
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42396814
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.42123249
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40208110
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40160442
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.40023095
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39944916
69VDR_23849224_ChIP-Seq_CD4+_Human1.39752574
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39127798
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39048532
72* SMAD4_21799915_ChIP-Seq_A2780_Human1.38871470
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.38256562
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37954245
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37435586
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.35866312
77AR_25329375_ChIP-Seq_VCAP_Human1.35856498
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35703589
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35682822
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34227831
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.33780330
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.33247577
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32460922
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31390619
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30473724
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29551784
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28816319
88CBP_20019798_ChIP-Seq_JUKART_Human1.28816319
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28326397
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27698831
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27350306
92KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26084433
93RUNX2_22187159_ChIP-Seq_PCA_Human1.25008927
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24276438
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24276438
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23713298
97ETS1_20019798_ChIP-Seq_JURKAT_Human1.23695320
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22539927
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22227661
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.21741939
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21697438
102YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21564956
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.20395511
104RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20318220
105EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20318220
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19990892
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18322781
108SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17799085
109JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17500050
110FOXP3_21729870_ChIP-Seq_TREG_Human1.17175598
111KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16523838
112IRF1_19129219_ChIP-ChIP_H3396_Human1.15701117
113ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15236740
114TCF4_23295773_ChIP-Seq_U87_Human1.15002771
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14967313
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14895483
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14369110
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13539672
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13038818
120SOX2_16153702_ChIP-ChIP_HESCs_Human1.12614589
121BCAT_22108803_ChIP-Seq_LS180_Human1.10483276
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10147950
123ER_23166858_ChIP-Seq_MCF-7_Human1.09354624
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09314881
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08517265
126TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08376976
127CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08315725
128HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07678838
129SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07501077
130ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07260386
131RING1B_27294783_Chip-Seq_ESCs_Mouse1.06005027
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05054472
133PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04769555
134SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04428102
135E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04217429
136PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04113517
137SRF_21415370_ChIP-Seq_HL-1_Mouse1.03277615
138NANOG_18555785_Chip-Seq_ESCs_Mouse1.02054708
139JUN_21703547_ChIP-Seq_K562_Human1.01537410
140SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01367548
141RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00594682
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00265147
143HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00029947
144TCF4_22108803_ChIP-Seq_LS180_Human0.99951370
145MYC_18940864_ChIP-ChIP_HL60_Human0.99671357
146TAL1_26923725_Chip-Seq_HPCs_Mouse0.99555885
147STAT3_23295773_ChIP-Seq_U87_Human0.99012074
148NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96404670
149E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96339051
150SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96270063
151NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95922526
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95825514
153GATA3_21867929_ChIP-Seq_CD8_Mouse0.95232212
154SOX9_26525672_Chip-Seq_HEART_Mouse0.95227885
155FLI1_21867929_ChIP-Seq_TH2_Mouse0.94639233
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94517323
157YY1_22570637_ChIP-Seq_MALME-3M_Human0.94230696
158SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.93916979
159TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93814564
160ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93770956
161POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93572298
162ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93559001
163HOXB7_26014856_ChIP-Seq_BT474_Human0.93235114
164CTCF_26484167_Chip-Seq_Bcells_Mouse0.92524938
165SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91051689
166SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91024181
167EST1_17652178_ChIP-ChIP_JURKAT_Human0.90360239
168CIITA_25753668_ChIP-Seq_RAJI_Human0.88644542
169TP53_22573176_ChIP-Seq_HFKS_Human0.86965205
170KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85593517
171KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85593517
172KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85593517
173IGF1R_20145208_ChIP-Seq_DFB_Human0.85263910
174TTF2_22483619_ChIP-Seq_HELA_Human0.84665356
175CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84298986
176CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83658730
177HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82098864
178KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81700386
179SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79659330
180POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.78815300
181EGR1_19374776_ChIP-ChIP_THP-1_Human0.78735447
182RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77763473
183POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.76590258
184SOX2_22085726_ChIP-Seq_NPCs_Mouse0.74968381
185JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.74361538
186GABP_19822575_ChIP-Seq_HepG2_Human0.74119151
187KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73194298
188TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73136927

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot6.31946538
2MP0003878_abnormal_ear_physiology6.31946538
3MP0009379_abnormal_foot_pigmentation3.86343952
4MP0003806_abnormal_nucleotide_metabolis3.52894881
5MP0010094_abnormal_chromosome_stability3.52300448
6MP0001485_abnormal_pinna_reflex3.48666264
7MP0008004_abnormal_stomach_pH3.39546927
8MP0003880_abnormal_central_pattern3.34324983
9MP0004885_abnormal_endolymph3.23622159
10MP0005174_abnormal_tail_pigmentation3.21533289
11MP0003693_abnormal_embryo_hatching3.21291417
12MP0000678_abnormal_parathyroid_gland3.01095229
13MP0008995_early_reproductive_senescence2.96177165
14MP0005409_darkened_coat_color2.84345140
15MP0002102_abnormal_ear_morphology2.84017920
16MP0000778_abnormal_nervous_system2.83284058
17MP0002736_abnormal_nociception_after2.79993853
18MP0005499_abnormal_olfactory_system2.65173137
19MP0005394_taste/olfaction_phenotype2.65173137
20MP0008789_abnormal_olfactory_epithelium2.63132115
21MP0003122_maternal_imprinting2.58744754
22MP0003111_abnormal_nucleus_morphology2.45773862
23MP0002132_abnormal_respiratory_system2.35793300
24MP0003786_premature_aging2.30625616
25MP0008058_abnormal_DNA_repair2.30300433
26MP0002653_abnormal_ependyma_morphology2.28731470
27MP0003121_genomic_imprinting2.28653706
28MP0001968_abnormal_touch/_nociception2.27319281
29MP0006072_abnormal_retinal_apoptosis2.15039935
30MP0006276_abnormal_autonomic_nervous2.03249991
31MP0001929_abnormal_gametogenesis2.03243032
32MP0003077_abnormal_cell_cycle2.01904008
33MP0002234_abnormal_pharynx_morphology1.99033648
34MP0004957_abnormal_blastocyst_morpholog1.97565715
35MP0003123_paternal_imprinting1.96021080
36MP0000049_abnormal_middle_ear1.94072753
37MP0002139_abnormal_hepatobiliary_system1.93723782
38MP0005410_abnormal_fertilization1.83080168
39MP0000631_abnormal_neuroendocrine_gland1.82536283
40MP0000015_abnormal_ear_pigmentation1.77813784
41MP0004130_abnormal_muscle_cell1.74953509
42MP0008877_abnormal_DNA_methylation1.74623114
43MP0002210_abnormal_sex_determination1.73874068
44MP0003787_abnormal_imprinting1.73072514
45MP0000653_abnormal_sex_gland1.69001024
46MP0000613_abnormal_salivary_gland1.68859669
47MP0001145_abnormal_male_reproductive1.67485698
48MP0004215_abnormal_myocardial_fiber1.65819655
49MP0003137_abnormal_impulse_conducting1.65161427
50MP0003698_abnormal_male_reproductive1.63998713
51MP0002751_abnormal_autonomic_nervous1.61652527
52MP0004859_abnormal_synaptic_plasticity1.59710430
53MP0002184_abnormal_innervation1.56459444
54MP0003705_abnormal_hypodermis_morpholog1.54161040
55MP0005423_abnormal_somatic_nervous1.54000004
56MP0002272_abnormal_nervous_system1.52406379
57MP0002233_abnormal_nose_morphology1.51505197
58MP0002938_white_spotting1.51255774
59MP0003011_delayed_dark_adaptation1.50971099
60MP0003635_abnormal_synaptic_transmissio1.49598529
61MP0009745_abnormal_behavioral_response1.48847228
62MP0000955_abnormal_spinal_cord1.48787877
63MP0005253_abnormal_eye_physiology1.48548873
64MP0002063_abnormal_learning/memory/cond1.46052057
65MP0002822_catalepsy1.43812739
66MP0005551_abnormal_eye_electrophysiolog1.43200787
67MP0001188_hyperpigmentation1.38059161
68MP0009780_abnormal_chondrocyte_physiolo1.36729124
69MP0004133_heterotaxia1.36136972
70MP0001984_abnormal_olfaction1.35400234
71MP0002160_abnormal_reproductive_system1.35387243
72MP0001293_anophthalmia1.32669369
73MP0002752_abnormal_somatic_nervous1.32301861
74MP0004142_abnormal_muscle_tone1.31569114
75MP0002572_abnormal_emotion/affect_behav1.31412917
76MP0001286_abnormal_eye_development1.31032473
77MP0003755_abnormal_palate_morphology1.30378579
78MP0000681_abnormal_thyroid_gland1.29045550
79MP0004811_abnormal_neuron_physiology1.25888403
80MP0003937_abnormal_limbs/digits/tail_de1.24448741
81MP0002882_abnormal_neuron_morphology1.24393173
82MP0003861_abnormal_nervous_system1.24300229
83MP0009384_cardiac_valve_regurgitation1.23083809
84MP0008961_abnormal_basal_metabolism1.22817814
85MP0002928_abnormal_bile_duct1.22402554
86MP0000462_abnormal_digestive_system1.20360843
87MP0003718_maternal_effect1.19078211
88MP0005670_abnormal_white_adipose1.16925358
89MP0002734_abnormal_mechanical_nocicepti1.16797115
90MP0002152_abnormal_brain_morphology1.15494608
91MP0005195_abnormal_posterior_eye1.14730732
92MP0004924_abnormal_behavior1.08973164
93MP0005386_behavior/neurological_phenoty1.08973164
94MP0001919_abnormal_reproductive_system1.07455226
95MP0002067_abnormal_sensory_capabilities1.06971461
96MP0001119_abnormal_female_reproductive1.06121881
97MP0005647_abnormal_sex_gland1.04182973
98MP0005391_vision/eye_phenotype1.03821318
99MP0004233_abnormal_muscle_weight1.02768496
100MP0002876_abnormal_thyroid_physiology1.02705177
101MP0003385_abnormal_body_wall1.01160548
102MP0001502_abnormal_circadian_rhythm1.00468003
103MP0002064_seizures0.99672983
104MP0005389_reproductive_system_phenotype0.99226434
105MP0004270_analgesia0.99135621
106MP0006292_abnormal_olfactory_placode0.97965442
107MP0003942_abnormal_urinary_system0.97766289
108MP0002733_abnormal_thermal_nociception0.96564501
109MP0001970_abnormal_pain_threshold0.96393211
110MP0002095_abnormal_skin_pigmentation0.94350402
111MP0002163_abnormal_gland_morphology0.91871659
112MP0005645_abnormal_hypothalamus_physiol0.91585182
113MP0002735_abnormal_chemical_nociception0.90589255
114MP0002161_abnormal_fertility/fecundity0.89861104
115MP0005367_renal/urinary_system_phenotyp0.87962525
116MP0000516_abnormal_urinary_system0.87962525
117MP0008057_abnormal_DNA_replication0.87420989
118MP0000490_abnormal_crypts_of0.85255370
119MP0002697_abnormal_eye_size0.84284926
120MP0001986_abnormal_taste_sensitivity0.82479528
121MP0000569_abnormal_digit_pigmentation0.81712593
122MP0009053_abnormal_anal_canal0.80152239
123MP0003935_abnormal_craniofacial_develop0.79811776
124MP0006054_spinal_hemorrhage0.79599943
125MP0005075_abnormal_melanosome_morpholog0.79031466
126MP0000566_synostosis0.77787740
127MP0002396_abnormal_hematopoietic_system0.76949490
128MP0004145_abnormal_muscle_electrophysio0.76448990
129MP0002116_abnormal_craniofacial_bone0.72454802
130MP0002066_abnormal_motor_capabilities/c0.71851235
131MP0002177_abnormal_outer_ear0.71494925
132MP0001764_abnormal_homeostasis0.71396671
133MP0003699_abnormal_female_reproductive0.70736479
134MP0005332_abnormal_amino_acid0.70486931
135MP0003690_abnormal_glial_cell0.70222164
136MP0001486_abnormal_startle_reflex0.68701860
137MP0002081_perinatal_lethality0.68153113
138MP0002109_abnormal_limb_morphology0.67006767
139MP0005187_abnormal_penis_morphology0.66363047
140MP0009046_muscle_twitch0.66096328
141MP0002282_abnormal_trachea_morphology0.66076213
142MP0001963_abnormal_hearing_physiology0.65009030
143MP0002019_abnormal_tumor_incidence0.63712009
144MP0008007_abnormal_cellular_replicative0.62746827
145MP0000313_abnormal_cell_death0.62364169
146MP0004197_abnormal_fetal_growth/weight/0.62325786
147MP0004808_abnormal_hematopoietic_stem0.62210441
148MP0003172_abnormal_lysosome_physiology0.61391243
149MP0000350_abnormal_cell_proliferation0.61130851
150MP0002127_abnormal_cardiovascular_syste0.61045407
151MP0005501_abnormal_skin_physiology0.58130136
152MP0001529_abnormal_vocalization0.57890774
153MP0008875_abnormal_xenobiotic_pharmacok0.55256120
154MP0003936_abnormal_reproductive_system0.54453551
155MP0000026_abnormal_inner_ear0.53012259
156MP0002249_abnormal_larynx_morphology0.52498348
157MP0001849_ear_inflammation0.51442173
158MP0000647_abnormal_sebaceous_gland0.50497380
159MP0002557_abnormal_social/conspecific_i0.49978880
160MP0005266_abnormal_metabolism0.49598332
161MP0001664_abnormal_digestion0.48645145
162MP0004084_abnormal_cardiac_muscle0.48475581
163MP0003890_abnormal_embryonic-extraembry0.48299748
164MP0009703_decreased_birth_body0.48224375
165MP0001915_intracranial_hemorrhage0.47344396
166MP0002138_abnormal_hepatobiliary_system0.45793428
167MP0000467_abnormal_esophagus_morphology0.45031807
168MP0002638_abnormal_pupillary_reflex0.44440310
169MP0003186_abnormal_redox_activity0.44366479
170MP0003119_abnormal_digestive_system0.43279527
171MP0001727_abnormal_embryo_implantation0.43020847
172MP0005171_absent_coat_pigmentation0.41306197
173MP0003938_abnormal_ear_development0.40810229
174MP0005084_abnormal_gallbladder_morpholo0.40770034
175MP0003868_abnormal_feces_composition0.40380205

Predicted human phenotypes

RankGene SetZ-score
1Thin bony cortex (HP:0002753)7.48783618
2Delayed epiphyseal ossification (HP:0002663)6.51289148
3Abnormality of the costochondral junction (HP:0000919)5.92744538
4Widely patent fontanelles and sutures (HP:0004492)5.87350685
5Enlarged epiphyses (HP:0010580)5.73437200
6Renovascular hypertension (HP:0100817)5.05705209
7Hyperacusis (HP:0010780)4.58279709
8Overriding aorta (HP:0002623)4.49249619
9Elfin facies (HP:0004428)4.44746829
10Onycholysis (HP:0001806)4.27042645
11Toxemia of pregnancy (HP:0100603)4.22540074
12Sensory axonal neuropathy (HP:0003390)4.21909742
13Insomnia (HP:0100785)4.06888818
14Abnormality of nail color (HP:0100643)4.04919799
15Pancreatic fibrosis (HP:0100732)3.97119602
16Renal duplication (HP:0000075)3.89662512
17Wide cranial sutures (HP:0010537)3.85775592
18Tubular atrophy (HP:0000092)3.78924013
19Ventricular fibrillation (HP:0001663)3.75626026
20Flat cornea (HP:0007720)3.74910877
21Flat occiput (HP:0005469)3.74304205
22True hermaphroditism (HP:0010459)3.58285002
23Molar tooth sign on MRI (HP:0002419)3.57217020
24Abnormality of midbrain morphology (HP:0002418)3.57217020
25Increased nuchal translucency (HP:0010880)3.50678573
26Abnormal trabecular bone morphology (HP:0100671)3.48398343
27Microvesicular hepatic steatosis (HP:0001414)3.48290817
28Abnormality of secondary sexual hair (HP:0009888)3.46858053
29Abnormality of the axillary hair (HP:0100134)3.46858053
30Bile duct proliferation (HP:0001408)3.31475284
31Abnormal biliary tract physiology (HP:0012439)3.31475284
32Metaphyseal irregularity (HP:0003025)3.28415337
33Polygenic inheritance (HP:0010982)3.24912578
34Colon cancer (HP:0003003)3.24434293
35Medial flaring of the eyebrow (HP:0010747)3.19975197
36Cortical dysplasia (HP:0002539)3.19710218
37Multifactorial inheritance (HP:0001426)3.14455730
38Tibial bowing (HP:0002982)3.13300237
39Gait imbalance (HP:0002141)3.11873603
40Abnormal hemoglobin (HP:0011902)3.07438508
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.04878205
42Drooling (HP:0002307)3.02028744
43Retinal dysplasia (HP:0007973)2.94820505
44Congenital primary aphakia (HP:0007707)2.92745062
45Nephrogenic diabetes insipidus (HP:0009806)2.92140062
46Abnormality of the diencephalon (HP:0010662)2.91808895
47Optic nerve hypoplasia (HP:0000609)2.86569200
48Abnormality of the renal medulla (HP:0100957)2.84379564
49Tubulointerstitial nephritis (HP:0001970)2.83865956
50Chromsome breakage (HP:0040012)2.79592341
51Excessive salivation (HP:0003781)2.74166245
52Lissencephaly (HP:0001339)2.73094557
53Intestinal atresia (HP:0011100)2.71492926
54Brittle hair (HP:0002299)2.63806100
55Postaxial foot polydactyly (HP:0001830)2.63498584
56Bowel diverticulosis (HP:0005222)2.63133450
57Sclerocornea (HP:0000647)2.58559392
58Sparse eyelashes (HP:0000653)2.57981302
59Vitreoretinal degeneration (HP:0000655)2.55732519
60Furrowed tongue (HP:0000221)2.54542744
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53457472
62Septo-optic dysplasia (HP:0100842)2.53032359
63Postaxial hand polydactyly (HP:0001162)2.52410164
64Supernumerary spleens (HP:0009799)2.50998573
65Abnormality of DNA repair (HP:0003254)2.49578017
66Bladder diverticulum (HP:0000015)2.47640849
67Depressed nasal tip (HP:0000437)2.47463704
68Focal motor seizures (HP:0011153)2.47125357
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.46725945
70Hyperventilation (HP:0002883)2.45192711
71Blepharitis (HP:0000498)2.44446929
72Hepatoblastoma (HP:0002884)2.41844139
73Pendular nystagmus (HP:0012043)2.41613427
74Abnormality of the carotid arteries (HP:0005344)2.38751357
75Pachygyria (HP:0001302)2.36845795
76Narrow forehead (HP:0000341)2.35820468
77Cystic liver disease (HP:0006706)2.35474908
78Anencephaly (HP:0002323)2.35241354
79Congenital sensorineural hearing impairment (HP:0008527)2.32057046
80Vaginal atresia (HP:0000148)2.31703617
81Growth hormone deficiency (HP:0000824)2.31654771
82Genital tract atresia (HP:0001827)2.30718492
83Rickets (HP:0002748)2.30563470
84Clubbing of toes (HP:0100760)2.26025071
85Absent speech (HP:0001344)2.24523715
86Gonadotropin excess (HP:0000837)2.24136191
87Hip dysplasia (HP:0001385)2.22715894
88Occipital encephalocele (HP:0002085)2.21937871
89Broad-based gait (HP:0002136)2.21697752
90Broad alveolar ridges (HP:0000187)2.21142765
91Dynein arm defect of respiratory motile cilia (HP:0012255)2.21051040
92Absent/shortened dynein arms (HP:0200106)2.21051040
93Ankyloglossia (HP:0010296)2.19844410
94Biliary tract neoplasm (HP:0100574)2.19593356
95Hepatocellular necrosis (HP:0001404)2.19271048
96Cheilitis (HP:0100825)2.17091807
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16822413
98Focal seizures (HP:0007359)2.14332073
99Urticaria (HP:0001025)2.13739322
100Renal dysplasia (HP:0000110)2.13533483
101Nephronophthisis (HP:0000090)2.11940198
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.11686654
103Type II lissencephaly (HP:0007260)2.11468179
104Stenosis of the external auditory canal (HP:0000402)2.11214161
105Facial hemangioma (HP:0000329)2.10891240
106Femoral bowing (HP:0002980)2.10847494
107Areflexia of lower limbs (HP:0002522)2.08731891
108Prolonged QT interval (HP:0001657)2.08601966
109Amyotrophic lateral sclerosis (HP:0007354)2.08550689
110Polyphagia (HP:0002591)2.08505744
111Abnormality of the preputium (HP:0100587)2.08352353
112Oligodactyly (hands) (HP:0001180)2.07996411
113Reticulocytopenia (HP:0001896)2.06616468
114Preaxial hand polydactyly (HP:0001177)2.05593552
115Poor coordination (HP:0002370)2.04866489
116Tubulointerstitial abnormality (HP:0001969)2.04212115
117Abnormality of homocysteine metabolism (HP:0010919)2.04212078
118Homocystinuria (HP:0002156)2.04212078
119Abnormality of the metopic suture (HP:0005556)2.04125175
120Hypoplastic toenails (HP:0001800)2.03560314
121Progressive cerebellar ataxia (HP:0002073)2.03233857
122Male pseudohermaphroditism (HP:0000037)2.02104677
123Dandy-Walker malformation (HP:0001305)2.00487159
124Premature loss of primary teeth (HP:0006323)2.00472808
12511 pairs of ribs (HP:0000878)1.99994636
126Palmar hyperkeratosis (HP:0010765)1.98668599
127Ankle contracture (HP:0006466)1.98351476
128Pancreatic cysts (HP:0001737)1.97190540
129Specific learning disability (HP:0001328)1.96309508
130Myokymia (HP:0002411)1.95206345
131Curly hair (HP:0002212)1.94603365
132Dry hair (HP:0011359)1.94248416
133Limb dystonia (HP:0002451)1.92584924
134Anomalous pulmonary venous return (HP:0010772)1.91756644
135Absent eyebrow (HP:0002223)1.90732108
136Chorioretinal coloboma (HP:0000567)1.89478761
137Anophthalmia (HP:0000528)1.89115464
138Broad foot (HP:0001769)1.89085947
139Hyporeflexia of lower limbs (HP:0002600)1.88397065
140Palmoplantar hyperkeratosis (HP:0000972)1.88031280
141Renal hypoplasia (HP:0000089)1.87417755
142Adrenal hypoplasia (HP:0000835)1.86448232
143Aganglionic megacolon (HP:0002251)1.86017737
144Abnormality of the renal cortex (HP:0011035)1.85636857
145Impulsivity (HP:0100710)1.85442344
146Diastasis recti (HP:0001540)1.85142158
147Chronic hepatic failure (HP:0100626)1.84911658
148Congenital hepatic fibrosis (HP:0002612)1.84400903
149Abnormality of the labia minora (HP:0012880)1.83466774
150Abnormality of the lower motor neuron (HP:0002366)1.82626139
151Micropenis (HP:0000054)1.82114320
152Abnormal pancreas size (HP:0012094)1.80854056
153Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80737537
154Hypoplasia of the brainstem (HP:0002365)1.80737537
155Thrombocytosis (HP:0001894)1.80733397
156Generalized aminoaciduria (HP:0002909)1.80595269
157Osteomalacia (HP:0002749)1.80423798
158Abnormal hair whorl (HP:0010721)1.79965148
159Congenital malformation of the right heart (HP:0011723)1.79726201
160Double outlet right ventricle (HP:0001719)1.79726201
161Agnosia (HP:0010524)1.79661644
162Pili torti (HP:0003777)1.79619586
163Hepatic necrosis (HP:0002605)1.78398951
164Elevated alkaline phosphatase (HP:0003155)1.78214889
165Small hand (HP:0200055)1.78146484
166Rib fusion (HP:0000902)1.77551333
167Spastic paraplegia (HP:0001258)1.77260084
168Abnormality of the corticospinal tract (HP:0002492)1.76727013
169Optic nerve coloboma (HP:0000588)1.75123881
170Absent septum pellucidum (HP:0001331)1.74821218
171Scrotal hypoplasia (HP:0000046)1.73675051
172Selective tooth agenesis (HP:0001592)1.73562835
173Aplasia/Hypoplasia of the lens (HP:0008063)1.73409342
174Abnormality of alkaline phosphatase activity (HP:0004379)1.73260960
175Spastic tetraplegia (HP:0002510)1.72852632
176Short 4th metacarpal (HP:0010044)1.72597674
177Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72597674
178Cerebellar dysplasia (HP:0007033)1.72496112
179Abnormal lung lobation (HP:0002101)1.72464187
180Short foot (HP:0001773)1.71596160
181Agitation (HP:0000713)1.70210152
182Abnormality of the aortic arch (HP:0012303)1.69987100
183Intellectual disability, moderate (HP:0002342)1.68496948
184Multicystic kidney dysplasia (HP:0000003)1.68370847
185Abnormal enzyme/coenzyme activity (HP:0012379)1.67735584
186Breech presentation (HP:0001623)1.66105313
187Hypercalciuria (HP:0002150)1.65573507
188Abnormal respiratory motile cilium morphology (HP:0005938)1.64552848
189Abnormal respiratory epithelium morphology (HP:0012253)1.64552848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK7.70582738
2CASK4.81372972
3PBK4.70052919
4MARK13.44823289
5WEE13.42317748
6MAP3K43.33899245
7EIF2AK13.16872620
8BRSK23.01478106
9PDK32.89431452
10PDK42.89431452
11WNK32.84492449
12FRK2.79606058
13BUB12.78590074
14MAP2K72.59054486
15BCR2.52993955
16MAPK132.49640521
17TLK12.47726938
18MAP3K92.30936272
19DYRK22.25091153
20TRIM282.22240337
21YES12.18872540
22PRKD32.11007782
23RPS6KA42.09468116
24EPHA42.08699880
25MAP4K21.96549052
26GRK11.95149448
27LATS11.90991586
28EPHB21.73078470
29EIF2AK31.70529759
30DYRK31.62511547
31CDK121.60877018
32PDK21.59360690
33MINK11.52774872
34NME21.47064162
35TTK1.45288302
36ZAK1.43738525
37TYK21.41837466
38NEK21.40051040
39WNK41.34862473
40MAP3K111.33406455
41CDK71.32517866
42TYRO31.30016372
43PNCK1.29209844
44NTRK31.28037948
45IRAK31.27505738
46BRSK11.27330653
47BCKDK1.27069483
48FGFR41.25046820
49MAP2K41.22235620
50PLK11.22002266
51AURKB1.21879183
52NUAK11.19263627
53MAP3K121.15820147
54CSNK1G31.15506524
55SGK21.13913683
56ADRBK21.09356150
57SGK2231.08326849
58SGK4941.08326849
59STK41.07041093
60CSNK1G11.06457085
61NTRK11.04044583
62NTRK21.03964728
63DYRK1A1.02700870
64MKNK21.02579414
65PAK31.01036563
66PLK20.98395293
67CSNK1A1L0.96916831
68INSRR0.95470715
69KIT0.94469566
70CDC70.92321295
71EIF2AK20.90853167
72AURKA0.89593136
73BRD40.89014137
74MAP3K60.85683286
75SRPK10.84610872
76BMPR1B0.84307176
77PRKCE0.84297745
78TNIK0.82125316
79ACVR1B0.81037663
80CHEK20.77982979
81TRIB30.77379011
82DYRK1B0.75867742
83OXSR10.75842082
84TGFBR10.75803271
85ERBB30.75685963
86PIK3CA0.75036605
87NLK0.74782229
88UHMK10.73797999
89STK38L0.70216715
90ATR0.68408428
91STK110.68375870
92BRAF0.67324234
93LMTK20.65970948
94PKN10.64583455
95STK390.64393033
96RPS6KA50.63813542
97STK160.61770338
98KSR10.61571116
99EPHA30.61378220
100ILK0.60303173
101CAMKK20.59570678
102PLK40.59399530
103SIK20.58979110
104CHEK10.57423071
105CDK50.55589491
106CDK140.51350519
107PRKCZ0.49921446
108CDK11A0.48505632
109CDK180.48330655
110PASK0.47306742
111CCNB10.46844338
112NEK60.46837132
113CAMK2A0.45425064
114ATM0.45388828
115CDK150.44282473
116IKBKE0.43839290
117MYLK0.41328439
118SGK30.41174167
119CSNK1G20.41117142
120BTK0.40938472
121STK30.40761611
122CSNK1A10.39010997
123PRKACA0.38746630
124JAK10.38685815
125DMPK0.36822788
126CSNK1D0.36268728
127CDK10.36057727
128PAK60.34675114
129MKNK10.34332649
130CDK30.33378414
131DAPK20.33186119
132CDK40.33160850
133CDK90.33089442
134PAK40.32854819
135TIE10.32300426
136ERBB20.31095595
137PINK10.29961323
138RIPK10.29677131
139TAOK30.29376525
140CDK20.29296057
141CDK190.29242833
142SIK30.29037644
143TEC0.27555906
144MATK0.27219440
145VRK10.26982241
146IKBKB0.26343731
147SYK0.26104117
148WNK10.25480035
149CSNK2A20.25284694
150MTOR0.25032835
151MAPK70.20534005
152CSNK2A10.19616875
153PRKCA0.19438881
154CAMK40.18836817
155GSK3B0.17654089
156FLT30.17490675
157MAPK150.17249475
158PRKCG0.17246628
159AKT30.17159856
160MAPK10.17147401
161PRKCI0.16362438
162PRKAA10.16246204
163MAPK110.15061773
164CSF1R0.14256638
165PLK30.14040355

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001006.43610971
2Pentose phosphate pathway_Homo sapiens_hsa000304.48565300
3Mismatch repair_Homo sapiens_hsa034304.31393174
4Homologous recombination_Homo sapiens_hsa034403.83482201
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.99505601
6Nicotine addiction_Homo sapiens_hsa050332.97552384
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87941355
8Ribosome_Homo sapiens_hsa030102.80915043
9DNA replication_Homo sapiens_hsa030302.75020315
10Fanconi anemia pathway_Homo sapiens_hsa034602.64223806
11Phototransduction_Homo sapiens_hsa047442.47784301
12Nucleotide excision repair_Homo sapiens_hsa034202.44914364
13Folate biosynthesis_Homo sapiens_hsa007902.26639442
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.14343046
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05901011
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.89548054
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86042315
18Axon guidance_Homo sapiens_hsa043601.84705064
19Spliceosome_Homo sapiens_hsa030401.80254884
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77140284
21* Systemic lupus erythematosus_Homo sapiens_hsa053221.74294610
22Fatty acid degradation_Homo sapiens_hsa000711.73832071
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.70018934
24Dopaminergic synapse_Homo sapiens_hsa047281.65904379
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64994715
26GABAergic synapse_Homo sapiens_hsa047271.64937339
27Vitamin B6 metabolism_Homo sapiens_hsa007501.64089105
28Glutamatergic synapse_Homo sapiens_hsa047241.63496551
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.57515975
30Biosynthesis of amino acids_Homo sapiens_hsa012301.55930237
31Cocaine addiction_Homo sapiens_hsa050301.54925967
32Base excision repair_Homo sapiens_hsa034101.52813004
33Morphine addiction_Homo sapiens_hsa050321.52212202
34Hedgehog signaling pathway_Homo sapiens_hsa043401.51806029
35Cell cycle_Homo sapiens_hsa041101.48419023
36Circadian entrainment_Homo sapiens_hsa047131.41322257
37Fatty acid biosynthesis_Homo sapiens_hsa000611.41188281
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40198893
39RNA transport_Homo sapiens_hsa030131.39321216
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38602438
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.36533619
42Staphylococcus aureus infection_Homo sapiens_hsa051501.27245543
43Oxidative phosphorylation_Homo sapiens_hsa001901.27065993
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26619208
45Long-term depression_Homo sapiens_hsa047301.22814687
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20720059
47Huntingtons disease_Homo sapiens_hsa050161.18611311
48Hippo signaling pathway_Homo sapiens_hsa043901.17103224
49Serotonergic synapse_Homo sapiens_hsa047261.16691683
50Linoleic acid metabolism_Homo sapiens_hsa005911.16503041
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16239317
52Olfactory transduction_Homo sapiens_hsa047401.14551322
53Basal transcription factors_Homo sapiens_hsa030221.14486907
54Taste transduction_Homo sapiens_hsa047421.09010418
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08180836
56p53 signaling pathway_Homo sapiens_hsa041151.07228149
57Cholinergic synapse_Homo sapiens_hsa047251.06706615
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06357235
59Parkinsons disease_Homo sapiens_hsa050121.05833953
60Carbon metabolism_Homo sapiens_hsa012001.03375737
61Insulin secretion_Homo sapiens_hsa049111.03029650
62RNA polymerase_Homo sapiens_hsa030201.01329862
63Fructose and mannose metabolism_Homo sapiens_hsa000510.99875215
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99268611
65Ether lipid metabolism_Homo sapiens_hsa005650.98930435
66One carbon pool by folate_Homo sapiens_hsa006700.96682853
67Wnt signaling pathway_Homo sapiens_hsa043100.92636522
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92629321
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92580646
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92013565
71Pyrimidine metabolism_Homo sapiens_hsa002400.91826335
72Selenocompound metabolism_Homo sapiens_hsa004500.91158841
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90984883
74Amphetamine addiction_Homo sapiens_hsa050310.90550727
75Collecting duct acid secretion_Homo sapiens_hsa049660.89634059
76Fatty acid metabolism_Homo sapiens_hsa012120.88099138
77Metabolic pathways_Homo sapiens_hsa011000.85462367
78Synaptic vesicle cycle_Homo sapiens_hsa047210.85051863
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80119748
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78477173
81Herpes simplex infection_Homo sapiens_hsa051680.77823222
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.76749041
83Sulfur relay system_Homo sapiens_hsa041220.74349329
84Retinol metabolism_Homo sapiens_hsa008300.72431434
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71956322
86Regulation of autophagy_Homo sapiens_hsa041400.68201306
87Gap junction_Homo sapiens_hsa045400.63543380
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63259410
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63059863
90Colorectal cancer_Homo sapiens_hsa052100.62599044
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62512295
92Alzheimers disease_Homo sapiens_hsa050100.62204497
93Butanoate metabolism_Homo sapiens_hsa006500.59891953
94beta-Alanine metabolism_Homo sapiens_hsa004100.59262520
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59045685
96ABC transporters_Homo sapiens_hsa020100.58940330
97mRNA surveillance pathway_Homo sapiens_hsa030150.58132809
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57338613
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55706333
100Melanogenesis_Homo sapiens_hsa049160.55636627
101Gastric acid secretion_Homo sapiens_hsa049710.53074751
102Peroxisome_Homo sapiens_hsa041460.52700377
103Ovarian steroidogenesis_Homo sapiens_hsa049130.51727240
104* Alcoholism_Homo sapiens_hsa050340.51715671
105Pyruvate metabolism_Homo sapiens_hsa006200.51606118
106Fatty acid elongation_Homo sapiens_hsa000620.51363960
107Dorso-ventral axis formation_Homo sapiens_hsa043200.50535075
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50141592
109cAMP signaling pathway_Homo sapiens_hsa040240.49129749
110TGF-beta signaling pathway_Homo sapiens_hsa043500.48917861
111Notch signaling pathway_Homo sapiens_hsa043300.47908282
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47017481
113Purine metabolism_Homo sapiens_hsa002300.45284660
114Influenza A_Homo sapiens_hsa051640.44995943
115Propanoate metabolism_Homo sapiens_hsa006400.44339535
116Histidine metabolism_Homo sapiens_hsa003400.42309138
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41443438
118Ras signaling pathway_Homo sapiens_hsa040140.41281681
119Sphingolipid metabolism_Homo sapiens_hsa006000.40205155
120Melanoma_Homo sapiens_hsa052180.38985364
121Cardiac muscle contraction_Homo sapiens_hsa042600.38656967
122Lysine degradation_Homo sapiens_hsa003100.38128636
123Legionellosis_Homo sapiens_hsa051340.37806207
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36482911
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36185574
126Circadian rhythm_Homo sapiens_hsa047100.36065496
127Vibrio cholerae infection_Homo sapiens_hsa051100.35807508
128Oocyte meiosis_Homo sapiens_hsa041140.34059087
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33999987
130Non-homologous end-joining_Homo sapiens_hsa034500.33489605
131Renin-angiotensin system_Homo sapiens_hsa046140.32880320
132Protein export_Homo sapiens_hsa030600.32346229
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.32130632
134Vitamin digestion and absorption_Homo sapiens_hsa049770.29186276
135Tryptophan metabolism_Homo sapiens_hsa003800.28271181
136ErbB signaling pathway_Homo sapiens_hsa040120.27308781
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26469983
138N-Glycan biosynthesis_Homo sapiens_hsa005100.26294250
139Antigen processing and presentation_Homo sapiens_hsa046120.24993382
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24904104
141Phenylalanine metabolism_Homo sapiens_hsa003600.22907893
142Starch and sucrose metabolism_Homo sapiens_hsa005000.22512516
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.21174001
144RNA degradation_Homo sapiens_hsa030180.19501369
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18218017
146Arginine and proline metabolism_Homo sapiens_hsa003300.17760229
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17373453
148Basal cell carcinoma_Homo sapiens_hsa052170.12752374
149* Viral carcinogenesis_Homo sapiens_hsa052030.12633738
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12145077
151PPAR signaling pathway_Homo sapiens_hsa033200.11453119

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