H2AFV

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.95032545
2regulation of odontogenesis of dentin-containing tooth (GO:0042487)6.92967223
3ribosomal small subunit assembly (GO:0000028)6.80008953
4transmission of nerve impulse (GO:0019226)6.71987229
5translational termination (GO:0006415)6.57990643
6ribosomal small subunit biogenesis (GO:0042274)5.69994318
7translational elongation (GO:0006414)5.69389835
8maturation of SSU-rRNA (GO:0030490)5.57765398
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.56237389
10cotranslational protein targeting to membrane (GO:0006613)5.44521411
11protein targeting to ER (GO:0045047)5.41592286
12sex differentiation (GO:0007548)5.41356570
13ribosomal large subunit biogenesis (GO:0042273)5.37263422
14telomere maintenance via semi-conservative replication (GO:0032201)5.27950530
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.26189013
16cellular protein complex disassembly (GO:0043624)5.24385537
17DNA strand elongation involved in DNA replication (GO:0006271)5.22469591
18establishment of protein localization to endoplasmic reticulum (GO:0072599)5.11466659
19viral life cycle (GO:0019058)5.11105681
20protein localization to endoplasmic reticulum (GO:0070972)5.05764211
21DNA strand elongation (GO:0022616)4.96089477
22translational initiation (GO:0006413)4.93214882
23DNA deamination (GO:0045006)4.85220419
24protein complex disassembly (GO:0043241)4.81596769
25mitotic recombination (GO:0006312)4.63571568
26telomere maintenance via recombination (GO:0000722)4.60565988
27macromolecular complex disassembly (GO:0032984)4.51381024
28chaperone-mediated protein transport (GO:0072321)4.42970899
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.40890149
30regulation of somitogenesis (GO:0014807)4.23231604
31spinal cord association neuron differentiation (GO:0021527)4.21560828
32chromatin remodeling at centromere (GO:0031055)4.15056213
33DNA unwinding involved in DNA replication (GO:0006268)4.13846321
34DNA replication initiation (GO:0006270)4.13308363
35CENP-A containing nucleosome assembly (GO:0034080)4.12799174
36kinetochore organization (GO:0051383)4.12355032
37kinetochore assembly (GO:0051382)4.07706602
38nuclear-transcribed mRNA catabolic process (GO:0000956)4.06583879
39nucleotide-excision repair, DNA gap filling (GO:0006297)4.05830858
40mitotic metaphase plate congression (GO:0007080)4.04996456
41negative regulation of oligodendrocyte differentiation (GO:0048715)4.03590543
42telomere maintenance via telomere lengthening (GO:0010833)4.02859198
43transcription-coupled nucleotide-excision repair (GO:0006283)4.01566453
44neuron fate specification (GO:0048665)3.88365868
45translation (GO:0006412)3.86905122
46chromosome condensation (GO:0030261)3.86633501
47mRNA catabolic process (GO:0006402)3.82901544
48spliceosomal snRNP assembly (GO:0000387)3.79013794
49pyrimidine dimer repair (GO:0006290)3.76363193
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.64411636
51DNA replication-independent nucleosome assembly (GO:0006336)3.64351195
52DNA replication-independent nucleosome organization (GO:0034724)3.64351195
53metaphase plate congression (GO:0051310)3.62853654
54RNA catabolic process (GO:0006401)3.61458381
55viral mRNA export from host cell nucleus (GO:0046784)3.60740041
56ribonucleoprotein complex biogenesis (GO:0022613)3.59740971
57DNA replication checkpoint (GO:0000076)3.56415203
58establishment of mitotic spindle localization (GO:0040001)3.55250933
59substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.51820087
60substrate-independent telencephalic tangential migration (GO:0021826)3.51820087
61left/right pattern formation (GO:0060972)3.50658617
62establishment of chromosome localization (GO:0051303)3.46302302
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46161433
64negative regulation of RNA splicing (GO:0033119)3.44941879
65mitotic sister chromatid segregation (GO:0000070)3.44077014
66somite development (GO:0061053)3.43009294
67spliceosomal complex assembly (GO:0000245)3.42061955
68protein targeting to membrane (GO:0006612)3.41322371
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.40947633
70protein localization to chromosome, centromeric region (GO:0071459)3.40612942
71negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.37454402
72protein localization to kinetochore (GO:0034501)3.37418980
73microtubule depolymerization (GO:0007019)3.36119737
74regulation of mitochondrial translation (GO:0070129)3.33866612
75histone exchange (GO:0043486)3.29897171
76adult walking behavior (GO:0007628)3.28820317
77negative regulation of cell cycle G2/M phase transition (GO:1902750)3.28438763
78axonal fasciculation (GO:0007413)3.27387626
79replication fork processing (GO:0031297)3.26093877
80establishment of mitotic spindle orientation (GO:0000132)3.25593749
81termination of RNA polymerase II transcription (GO:0006369)3.21853889
82establishment of protein localization to mitochondrial membrane (GO:0090151)3.20875600
83resolution of meiotic recombination intermediates (GO:0000712)3.18941808
84eye photoreceptor cell differentiation (GO:0001754)3.18307888
85photoreceptor cell differentiation (GO:0046530)3.18307888
86establishment of integrated proviral latency (GO:0075713)3.17407181
87attachment of spindle microtubules to kinetochore (GO:0008608)3.17136606
88pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.15565415
89sister chromatid segregation (GO:0000819)3.13468636
90establishment of spindle orientation (GO:0051294)3.13028779
91neuron projection extension involved in neuron projection guidance (GO:1902284)3.11226990
92axon extension involved in axon guidance (GO:0048846)3.11226990
93response to UV-B (GO:0010224)3.09684381
94DNA ligation (GO:0006266)3.09258714
95rRNA processing (GO:0006364)3.08345715
96DNA replication-dependent nucleosome assembly (GO:0006335)3.07115019
97DNA replication-dependent nucleosome organization (GO:0034723)3.07115019
98DNA topological change (GO:0006265)3.06662682
99rRNA modification (GO:0000154)3.06361604
100histone mRNA metabolic process (GO:0008334)3.06311657
101DNA packaging (GO:0006323)3.05598007
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04265263
103multicellular organismal signaling (GO:0035637)3.01210693
104regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.00172724
105cellular component biogenesis (GO:0044085)2.99161290
106regulation of odontogenesis (GO:0042481)2.98914571
107rRNA metabolic process (GO:0016072)2.98226061
108negative regulation of telomere maintenance (GO:0032205)2.97556030
109establishment of spindle localization (GO:0051293)2.95594092
110mRNA splicing, via spliceosome (GO:0000398)2.95327279
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.95327279
112telomere organization (GO:0032200)2.94163276
113ATP-dependent chromatin remodeling (GO:0043044)2.93384684
114telomere maintenance (GO:0000723)2.93356706
115base-excision repair (GO:0006284)2.93117007
116nucleotide-excision repair (GO:0006289)2.92534504
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91698894
118RNA splicing, via transesterification reactions (GO:0000375)2.91481525
119dorsal/ventral neural tube patterning (GO:0021904)2.90348720
120pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88810399
121mitotic sister chromatid cohesion (GO:0007064)2.88688877
122negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88502980
123cell proliferation in forebrain (GO:0021846)2.88299373
124regulation of spindle organization (GO:0090224)2.87958826
125negative regulation of mRNA processing (GO:0050686)2.87930739
126oxidative phosphorylation (GO:0006119)2.86021415
127formation of translation preinitiation complex (GO:0001731)2.85909150
128mitotic chromosome condensation (GO:0007076)2.85892737
129heterochromatin organization (GO:0070828)2.83433247
130protein neddylation (GO:0045116)2.83312126
131regulation of double-strand break repair via homologous recombination (GO:0010569)2.83149639
132negative regulation of Notch signaling pathway (GO:0045746)2.82501053
133DNA integration (GO:0015074)2.79202509
134chromatin assembly or disassembly (GO:0006333)2.78923890
135protein complex localization (GO:0031503)2.78571736
136meiotic chromosome segregation (GO:0045132)2.77680045
137positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76825272
138dendritic spine morphogenesis (GO:0060997)2.74332298
139axon extension (GO:0048675)2.70819935
140tongue development (GO:0043586)2.70575755
141mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68826246
142regulation of centriole replication (GO:0046599)2.67168577
143radial glial cell differentiation (GO:0060019)2.64696966
144maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63447397
145protein localization to chromosome (GO:0034502)2.62828030
146DNA strand renaturation (GO:0000733)2.62056611
147axon ensheathment in central nervous system (GO:0032291)2.60696216
148central nervous system myelination (GO:0022010)2.60696216
149body morphogenesis (GO:0010171)2.60485806
150short-term memory (GO:0007614)2.59682227
151cerebral cortex development (GO:0021987)2.56196445
152ATP synthesis coupled proton transport (GO:0015986)2.53221144

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* E2F7_22180533_ChIP-Seq_HELA_Human8.09462360
2EZH2_22144423_ChIP-Seq_EOC_Human5.55948453
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.94070144
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.23315833
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85060896
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76205202
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.59373662
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21398797
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07282398
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99957561
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97625636
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96931519
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.93591364
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.93450797
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85877164
16* XRN2_22483619_ChIP-Seq_HELA_Human2.78113561
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73845714
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66750694
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.59542151
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58821666
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55285089
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33098004
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21368831
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15978393
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15069793
26DCP1A_22483619_ChIP-Seq_HELA_Human2.07444022
27VDR_23849224_ChIP-Seq_CD4+_Human2.06976047
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.05932407
29TTF2_22483619_ChIP-Seq_HELA_Human2.03237274
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01797082
31FOXP3_21729870_ChIP-Seq_TREG_Human1.94231330
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92451188
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89976830
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88921990
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.81950917
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.81263190
37GABP_19822575_ChIP-Seq_HepG2_Human1.81126395
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78556866
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78208299
40AR_21909140_ChIP-Seq_LNCAP_Human1.78138086
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77837659
42CIITA_25753668_ChIP-Seq_RAJI_Human1.77195589
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76213363
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74452023
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73565634
46* E2F1_21310950_ChIP-Seq_MCF-7_Human1.71444872
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69248386
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.66439744
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65852808
50KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.58916207
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57405754
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52582458
53VDR_21846776_ChIP-Seq_THP-1_Human1.48948491
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45754558
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45096708
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43777232
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41896608
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41564551
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41110798
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40171898
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.39999568
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39719573
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39471215
64MYC_22102868_ChIP-Seq_BL_Human1.38578725
65* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35460597
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32951033
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32488939
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32050453
69ELK1_19687146_ChIP-ChIP_HELA_Human1.29161184
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.28992254
71IRF1_19129219_ChIP-ChIP_H3396_Human1.28778644
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.27757370
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26479844
74MYC_18940864_ChIP-ChIP_HL60_Human1.24817074
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23854267
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23746806
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21305061
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20977746
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20103435
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18164107
81KDM5A_27292631_Chip-Seq_BREAST_Human1.17381953
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15193563
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10771204
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.10603362
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.09989653
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.07727268
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06700809
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06553208
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.05985967
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05550648
91ELK1_22589737_ChIP-Seq_MCF10A_Human1.03114001
92TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01897942
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.01555602
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00603753
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00531571
96YY1_22570637_ChIP-Seq_MALME-3M_Human0.98265683
97RNF2_27304074_Chip-Seq_NSC_Mouse0.97876815
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97042898
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96737193
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95781016
101CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95433204
102EGR1_19374776_ChIP-ChIP_THP-1_Human0.95403762
103OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95346008
104REST_18959480_ChIP-ChIP_MESCs_Mouse0.93304747
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93052066
106SOX9_26525672_Chip-Seq_HEART_Mouse0.92986500
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91434724
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90146775
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.89671221
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89043604
111KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86856056
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86811901
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85480393
114* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85086309
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84582812
116EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83804913
117RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83804913
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83105086
119REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82561699
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82142243
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81643049
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.81379354
123* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81340369
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81222811
125MAF_26560356_Chip-Seq_TH2_Human0.79921465
126FOXP1_21924763_ChIP-Seq_HESCs_Human0.79090715
127JARID2_20075857_ChIP-Seq_MESCs_Mouse0.78469467
128REST_21632747_ChIP-Seq_MESCs_Mouse0.77953170
129FUS_26573619_Chip-Seq_HEK293_Human0.77807090
130ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76529394
131RBPJ_22232070_ChIP-Seq_NCS_Mouse0.76047447
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74731454
133SPI1_23547873_ChIP-Seq_NB4_Human0.74293282
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74190942
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.74059170
136RING1B_27294783_Chip-Seq_ESCs_Mouse0.73908508
137SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73743316
138* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72920987
139PADI4_21655091_ChIP-ChIP_MCF-7_Human0.72914679
140LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72802187
141SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.72558666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.61109123
2MP0009379_abnormal_foot_pigmentation4.34160014
3MP0004957_abnormal_blastocyst_morpholog3.95300210
4MP0003111_abnormal_nucleus_morphology3.92358068
5MP0003077_abnormal_cell_cycle3.86722255
6MP0010094_abnormal_chromosome_stability3.73243966
7MP0003787_abnormal_imprinting3.62210142
8MP0003011_delayed_dark_adaptation3.21574683
9MP0008058_abnormal_DNA_repair2.82246550
10MP0008007_abnormal_cellular_replicative2.80880565
11MP0000372_irregular_coat_pigmentation2.65212845
12MP0008932_abnormal_embryonic_tissue2.59571892
13MP0008057_abnormal_DNA_replication2.47976007
14MP0006292_abnormal_olfactory_placode2.45912288
15MP0005171_absent_coat_pigmentation2.45062926
16MP0010030_abnormal_orbit_morphology2.43651300
17MP0000049_abnormal_middle_ear2.29050074
18MP0003122_maternal_imprinting2.28683632
19MP0005379_endocrine/exocrine_gland_phen2.11888412
20MP0003283_abnormal_digestive_organ1.86722462
21MP0002233_abnormal_nose_morphology1.85955544
22MP0000778_abnormal_nervous_system1.81821801
23MP0003123_paternal_imprinting1.80968479
24MP0008789_abnormal_olfactory_epithelium1.79312476
25MP0003315_abnormal_perineum_morphology1.78459105
26MP0001270_distended_abdomen1.74078096
27MP0003786_premature_aging1.73110145
28MP0002822_catalepsy1.70069821
29MP0002396_abnormal_hematopoietic_system1.69432566
30MP0001529_abnormal_vocalization1.65916023
31MP0000350_abnormal_cell_proliferation1.64677505
32MP0000534_abnormal_ureter_morphology1.63875615
33MP0002653_abnormal_ependyma_morphology1.62755429
34MP0009053_abnormal_anal_canal1.57855906
35MP0002249_abnormal_larynx_morphology1.57055006
36MP0001730_embryonic_growth_arrest1.53004898
37MP0000490_abnormal_crypts_of1.47892595
38MP0006276_abnormal_autonomic_nervous1.45371967
39MP0000566_synostosis1.44246367
40MP0009046_muscle_twitch1.43906008
41MP0004808_abnormal_hematopoietic_stem1.43636482
42MP0000313_abnormal_cell_death1.41874263
43MP0000750_abnormal_muscle_regeneration1.34630824
44MP0000858_altered_metastatic_potential1.32238117
45MP0003861_abnormal_nervous_system1.31626281
46MP0002092_abnormal_eye_morphology1.29922593
47MP0009278_abnormal_bone_marrow1.29343488
48MP0002116_abnormal_craniofacial_bone1.26462013
49MP0003938_abnormal_ear_development1.26130752
50MP0003880_abnormal_central_pattern1.25851167
51MP0003136_yellow_coat_color1.23676140
52MP0001485_abnormal_pinna_reflex1.22639573
53MP0001905_abnormal_dopamine_level1.22510637
54MP0000569_abnormal_digit_pigmentation1.21866460
55MP0003942_abnormal_urinary_system1.21408195
56MP0002928_abnormal_bile_duct1.21154826
57MP0001293_anophthalmia1.20473285
58MP0006036_abnormal_mitochondrial_physio1.20052009
59MP0005394_taste/olfaction_phenotype1.19284670
60MP0005499_abnormal_olfactory_system1.19284670
61MP0002019_abnormal_tumor_incidence1.18833169
62MP0002085_abnormal_embryonic_tissue1.18567984
63MP0001697_abnormal_embryo_size1.18519444
64MP0002234_abnormal_pharynx_morphology1.14304075
65MP0003119_abnormal_digestive_system1.13831865
66MP0002102_abnormal_ear_morphology1.11939025
67MP0000955_abnormal_spinal_cord1.11905759
68MP0002184_abnormal_innervation1.11899960
69MP0001672_abnormal_embryogenesis/_devel1.11894826
70MP0005380_embryogenesis_phenotype1.11894826
71MP0002152_abnormal_brain_morphology1.11771220
72MP0002210_abnormal_sex_determination1.11124298
73MP0002132_abnormal_respiratory_system1.10672142
74MP0002080_prenatal_lethality1.08794171
75MP0003763_abnormal_thymus_physiology1.07919993
76MP0005195_abnormal_posterior_eye1.07863108
77MP0005174_abnormal_tail_pigmentation1.06657298
78MP0000631_abnormal_neuroendocrine_gland1.06577835
79MP0006035_abnormal_mitochondrial_morpho1.05696932
80MP0002932_abnormal_joint_morphology1.04115473
81MP0008877_abnormal_DNA_methylation1.03159567
82MP0005423_abnormal_somatic_nervous1.02842815
83MP0003567_abnormal_fetal_cardiomyocyte1.02376387
84MP0005646_abnormal_pituitary_gland1.02146414
85MP0002752_abnormal_somatic_nervous1.01421462
86MP0000537_abnormal_urethra_morphology1.01258720
87MP0002882_abnormal_neuron_morphology1.01030137
88MP0004381_abnormal_hair_follicle0.99272074
89MP0003936_abnormal_reproductive_system0.99021171
90MP0002272_abnormal_nervous_system0.97772447
91MP0001188_hyperpigmentation0.97605578
92MP0000703_abnormal_thymus_morphology0.97133924
93MP0005248_abnormal_Harderian_gland0.95853403
94MP0004859_abnormal_synaptic_plasticity0.95750788
95MP0000026_abnormal_inner_ear0.95468226
96MP0001545_abnormal_hematopoietic_system0.95386078
97MP0005397_hematopoietic_system_phenotyp0.95386078
98MP0003984_embryonic_growth_retardation0.95171130
99MP0004811_abnormal_neuron_physiology0.94962545
100MP0005220_abnormal_exocrine_pancreas0.94420193
101MP0003937_abnormal_limbs/digits/tail_de0.93953412
102MP0002163_abnormal_gland_morphology0.93818427
103MP0002160_abnormal_reproductive_system0.93712872
104MP0002088_abnormal_embryonic_growth/wei0.92927783
105MP0002282_abnormal_trachea_morphology0.92124877
106MP0009384_cardiac_valve_regurgitation0.89122840
107MP0002938_white_spotting0.88666732
108MP0003303_peritoneal_inflammation0.87889357
109MP0003718_maternal_effect0.86722371
110MP0003935_abnormal_craniofacial_develop0.86548850
111MP0002084_abnormal_developmental_patter0.85665065
112MP0003385_abnormal_body_wall0.85146008
113MP0002557_abnormal_social/conspecific_i0.85037548
114MP0009333_abnormal_splenocyte_physiolog0.84791888
115MP0002067_abnormal_sensory_capabilities0.84376534
116MP0000427_abnormal_hair_cycle0.83768213
117MP0003890_abnormal_embryonic-extraembry0.82681081
118MP0001346_abnormal_lacrimal_gland0.81834150
119MP0001727_abnormal_embryo_implantation0.81764359
120MP0001145_abnormal_male_reproductive0.81521231
121MP0003121_genomic_imprinting0.80703340
122MP0002095_abnormal_skin_pigmentation0.80573541
123MP0004142_abnormal_muscle_tone0.80356970
124MP0004133_heterotaxia0.80017406
125MP0001119_abnormal_female_reproductive0.79677435
126MP0002098_abnormal_vibrissa_morphology0.79647174
127MP0002751_abnormal_autonomic_nervous0.79305028
128MP0000358_abnormal_cell_content/0.79294878
129MP0001286_abnormal_eye_development0.79222029
130MP0008995_early_reproductive_senescence0.77414012
131MP0002086_abnormal_extraembryonic_tissu0.76514189
132MP0003186_abnormal_redox_activity0.76451322
133MP0005257_abnormal_intraocular_pressure0.76015091
134MP0006054_spinal_hemorrhage0.75371200
135MP0002697_abnormal_eye_size0.75128015
136MP0002114_abnormal_axial_skeleton0.74853165
137MP0000428_abnormal_craniofacial_morphol0.74660565
138MP0002722_abnormal_immune_system0.74476847
139MP0002063_abnormal_learning/memory/cond0.73570736
140MP0004197_abnormal_fetal_growth/weight/0.73321180
141MP0002111_abnormal_tail_morphology0.72980678
142MP0002398_abnormal_bone_marrow0.72855691
143MP0000678_abnormal_parathyroid_gland0.72674481
144MP0000465_gastrointestinal_hemorrhage0.71825222
145MP0006072_abnormal_retinal_apoptosis0.71802738
146MP0005501_abnormal_skin_physiology0.70487697
147MP0000653_abnormal_sex_gland0.70240335
148MP0001663_abnormal_digestive_system0.69900097
149MP0003755_abnormal_palate_morphology0.69355764
150MP0005391_vision/eye_phenotype0.67959679
151MP0001929_abnormal_gametogenesis0.67910854
152MP0002638_abnormal_pupillary_reflex0.66684933
153MP0008569_lethality_at_weaning0.66026257
154MP0002109_abnormal_limb_morphology0.65287688
155MP0004147_increased_porphyrin_level0.64659571
156MP0009745_abnormal_behavioral_response0.63283707
157MP0001963_abnormal_hearing_physiology0.62891132

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.60770134
2Abnormality of cells of the erythroid lineage (HP:0012130)4.91437407
3Colon cancer (HP:0003003)4.89842967
4Aplasia/Hypoplasia of the sacrum (HP:0008517)4.86211279
5Abnormal number of erythroid precursors (HP:0012131)4.78627409
6Irregular epiphyses (HP:0010582)4.49360961
7Large eyes (HP:0001090)4.24493723
8Rectal prolapse (HP:0002035)4.24001853
9Macrocytic anemia (HP:0001972)4.13707981
10Microretrognathia (HP:0000308)4.12809413
11Broad distal phalanx of finger (HP:0009836)4.04402675
12Rhabdomyosarcoma (HP:0002859)3.96639458
13Patent foramen ovale (HP:0001655)3.81903400
14Pallor (HP:0000980)3.81712745
15Cerebellar dysplasia (HP:0007033)3.67418094
16Aplastic anemia (HP:0001915)3.61220300
1711 pairs of ribs (HP:0000878)3.56813805
18Impulsivity (HP:0100710)3.52132598
19Lissencephaly (HP:0001339)3.42429737
20Medulloblastoma (HP:0002885)3.34122673
21Oral leukoplakia (HP:0002745)3.14594706
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.10951582
23Absent thumb (HP:0009777)3.02872972
24Patellar aplasia (HP:0006443)3.02170320
25Abnormal hemoglobin (HP:0011902)3.01153698
26Chromsome breakage (HP:0040012)3.00839371
27Meckel diverticulum (HP:0002245)2.98514150
28Rib fusion (HP:0000902)2.97612522
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96999974
30Abnormality of the ileum (HP:0001549)2.92275264
31Abnormality of the preputium (HP:0100587)2.89695873
32Aplasia/Hypoplasia of the patella (HP:0006498)2.89359451
33Abnormal number of incisors (HP:0011064)2.84455551
34Abnormality of the labia minora (HP:0012880)2.79940809
35Triphalangeal thumb (HP:0001199)2.79212732
36Hypoplastic pelvis (HP:0008839)2.76879188
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73541609
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73541609
39Hepatocellular necrosis (HP:0001404)2.64336456
40Oligodactyly (hands) (HP:0001180)2.61969275
41Neoplasm of striated muscle (HP:0009728)2.61829206
42Abnormality of DNA repair (HP:0003254)2.61082376
43Hemiparesis (HP:0001269)2.60302497
44Type II lissencephaly (HP:0007260)2.60170116
45Mitochondrial inheritance (HP:0001427)2.60069066
46Tracheomalacia (HP:0002779)2.57943397
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.57342925
48Hyperthyroidism (HP:0000836)2.56900009
49Neoplasm of the pancreas (HP:0002894)2.55214245
50Flat capital femoral epiphysis (HP:0003370)2.53739706
51Adrenal hypoplasia (HP:0000835)2.49687579
52Pendular nystagmus (HP:0012043)2.43516943
53Absent epiphyses (HP:0010577)2.43486804
54Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.43486804
55Abnormality of chromosome stability (HP:0003220)2.40409521
56Rough bone trabeculation (HP:0100670)2.39924778
57Neoplasm of the colon (HP:0100273)2.39818163
58Oligodactyly (HP:0012165)2.39560170
59Duodenal stenosis (HP:0100867)2.39480314
60Small intestinal stenosis (HP:0012848)2.39480314
61Acute necrotizing encephalopathy (HP:0006965)2.39045015
62Missing ribs (HP:0000921)2.36886177
63Septo-optic dysplasia (HP:0100842)2.36569537
64Thrombocytosis (HP:0001894)2.34472705
65Hepatic necrosis (HP:0002605)2.33735534
66Disproportionate short-trunk short stature (HP:0003521)2.32680357
67Exertional dyspnea (HP:0002875)2.30972317
68Increased CSF lactate (HP:0002490)2.29056170
69Papilledema (HP:0001085)2.28379885
70Ectopic kidney (HP:0000086)2.28256576
71Medial flaring of the eyebrow (HP:0010747)2.26829232
72Irregular vertebral endplates (HP:0003301)2.26203764
73Birth length less than 3rd percentile (HP:0003561)2.26093180
74Selective tooth agenesis (HP:0001592)2.25837601
75Abnormality of the 4th metacarpal (HP:0010012)2.25817899
76Abnormal mitochondria in muscle tissue (HP:0008316)2.24614668
77Pachygyria (HP:0001302)2.23577579
78Beaking of vertebral bodies (HP:0004568)2.22023545
79Hypochromic anemia (HP:0001931)2.21992129
80Partial duplication of thumb phalanx (HP:0009944)2.21319087
81Nephroblastoma (Wilms tumor) (HP:0002667)2.19713046
82Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18983673
83Abnormality of the proximal phalanges of the hand (HP:0009834)2.18657652
84Abnormal lung lobation (HP:0002101)2.17579748
85Hypoplastic iliac wings (HP:0002866)2.17105780
86Increased hepatocellular lipid droplets (HP:0006565)2.17012301
87Breast hypoplasia (HP:0003187)2.16487652
88Myelodysplasia (HP:0002863)2.16219475
89Duplication of thumb phalanx (HP:0009942)2.14983394
90Esophageal atresia (HP:0002032)2.13195151
91Depressed nasal ridge (HP:0000457)2.12946136
92Spastic tetraparesis (HP:0001285)2.09282182
93Partial duplication of the phalanx of hand (HP:0009999)2.08898516
94Horseshoe kidney (HP:0000085)2.08191625
95Broad phalanges of the hand (HP:0009768)2.05474230
96Cortical dysplasia (HP:0002539)2.04201260
97Abnormality of the duodenum (HP:0002246)2.02334376
98Heterotopia (HP:0002282)2.01822495
99Bicuspid aortic valve (HP:0001647)2.01587095
100Gait imbalance (HP:0002141)2.01518744
101Increased serum lactate (HP:0002151)2.01421452
102Embryonal renal neoplasm (HP:0011794)2.00658270
103Optic nerve coloboma (HP:0000588)2.00356853
104Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.99506410
105Vertebral hypoplasia (HP:0008417)1.99506410
106Sloping forehead (HP:0000340)1.98893741
107Biliary tract neoplasm (HP:0100574)1.98074288
108Congenital primary aphakia (HP:0007707)1.97808383
109Tracheoesophageal fistula (HP:0002575)1.97233298
110Carpal bone hypoplasia (HP:0001498)1.96973688
111Abnormality of reticulocytes (HP:0004312)1.94533783
112Broad finger (HP:0001500)1.94055897
113Trismus (HP:0000211)1.93965416
114Hypoplasia of the radius (HP:0002984)1.91108934
115Abnormality of the metopic suture (HP:0005556)1.90683979
116Secondary amenorrhea (HP:0000869)1.89947542
117Progressive external ophthalmoplegia (HP:0000590)1.89543884
118Progressive macrocephaly (HP:0004481)1.89354005
119Turricephaly (HP:0000262)1.88800516
120Pancytopenia (HP:0001876)1.88660548
121Esophageal neoplasm (HP:0100751)1.87896983
122Neoplasm of head and neck (HP:0012288)1.87896983
123Nephrogenic diabetes insipidus (HP:0009806)1.87894076
124Acute encephalopathy (HP:0006846)1.87872045
125Lipid accumulation in hepatocytes (HP:0006561)1.87236684
126Poikiloderma (HP:0001029)1.87215604
127Premature graying of hair (HP:0002216)1.86106018
128Bone marrow hypocellularity (HP:0005528)1.83818446
129Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83339589
130Flattened epiphyses (HP:0003071)1.82843700
131Respiratory difficulties (HP:0002880)1.82442865
132Embryonal neoplasm (HP:0002898)1.82423214
133Abnormality of the epiphysis of the femoral head (HP:0010574)1.81552733
134Delayed epiphyseal ossification (HP:0002663)1.81043843
135Hypoplastic ilia (HP:0000946)1.80235942
136Neoplasm of the rectum (HP:0100743)1.79771518
137Abnormality of the vertebral endplates (HP:0005106)1.79036621
138Thoracic kyphosis (HP:0002942)1.78434413
139Absent radius (HP:0003974)1.78132214
140Cerebellar hypoplasia (HP:0001321)1.77180538
141Holoprosencephaly (HP:0001360)1.77095569
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76940975
143Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.76388556
144Increased intramyocellular lipid droplets (HP:0012240)1.75316208
145Duplicated collecting system (HP:0000081)1.74701081
146Carpal synostosis (HP:0009702)1.74431193
147Abnormality of the carotid arteries (HP:0005344)1.72705460
148Broad phalanx (HP:0006009)1.72225846
149Hypoplasia of the brainstem (HP:0002365)1.72099133
150Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72099133
151Polymicrogyria (HP:0002126)1.71047548
152Postnatal microcephaly (HP:0005484)1.70952776
153Maternal diabetes (HP:0009800)1.70226865
154Acute lymphatic leukemia (HP:0006721)1.70016559
155Absent septum pellucidum (HP:0001331)1.69469263
156Myokymia (HP:0002411)1.69410651
157Abnormality of the fingertips (HP:0001211)1.69180014
158Aplasia involving forearm bones (HP:0009822)1.68789816
159Absent forearm bone (HP:0003953)1.68789816
160Concave nail (HP:0001598)1.68562841
161Flat acetabular roof (HP:0003180)1.68374450
162Anencephaly (HP:0002323)1.68095643
163Fibular hypoplasia (HP:0003038)1.67303527
164Meningocele (HP:0002435)1.67167252
165Abnormality of femoral epiphyses (HP:0006499)1.66795741
166Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.66795741
167Poor coordination (HP:0002370)1.66640922
168Neoplasm of the adrenal cortex (HP:0100641)1.65840009
169Broad thumb (HP:0011304)1.65642827
170Progressive muscle weakness (HP:0003323)1.65314109
171Abnormality of the diencephalon (HP:0010662)1.63327906
172Abnormality of the anterior horn cell (HP:0006802)1.63062957
173Degeneration of anterior horn cells (HP:0002398)1.63062957
174Diastasis recti (HP:0001540)1.62138325
175Broad foot (HP:0001769)1.61275080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.74207082
2WEE13.60052947
3STK163.56050383
4RPS6KA43.38504314
5ACVR1B3.21673750
6TLK13.21022339
7MAP3K103.12843223
8SRPK12.88722892
9NME22.73093264
10VRK22.57109455
11PASK2.55309026
12CDC72.54440275
13NEK22.49424093
14MAP3K62.36621719
15DYRK32.07524419
16MINK12.03187253
17VRK12.02864637
18EEF2K1.90565040
19AURKB1.88451556
20TTK1.84274482
21MKNK11.80009097
22CDK191.78854391
23TESK21.75685695
24TAF11.67045562
25EIF2AK11.64692443
26MKNK21.63318760
27PLK11.59631899
28PRKD31.54883652
29CCNB11.52331507
30MAP3K91.50699552
31MAP3K111.49036997
32BRSK21.46701075
33CDK41.44826372
34RPS6KA51.40678110
35RPS6KB21.40415748
36PIK3CA1.38361208
37CDK71.35328476
38BRSK11.30237744
39WNK41.20661146
40BRD41.20225131
41WNK31.18302621
42ATR1.18195515
43NTRK21.14492057
44RIPK11.11005614
45TGFBR11.10751546
46TYRO31.10634004
47LMTK21.06629985
48PLK41.06478475
49DMPK1.05993349
50CDK81.04552975
51CDK141.04018281
52AURKA1.03151370
53BCKDK1.02807038
54PAK40.99494615
55CDK150.97823914
56DYRK20.96585251
57NTRK30.95656945
58CHEK20.94666360
59MARK30.93780333
60MAPKAPK30.93776990
61CDK180.91918975
62NUAK10.88108597
63STK40.85925893
64KDR0.84603057
65SIK20.81751808
66UHMK10.80920392
67PNCK0.79726724
68MAP2K40.79691547
69EPHB20.79612906
70STK390.79343592
71AKT20.78733546
72EPHA40.77775730
73STK110.76250516
74NTRK10.75846439
75IRAK40.75435469
76CSNK2A10.71512306
77PAK60.71164453
78CSNK1E0.70991995
79CASK0.70289665
80PBK0.70167693
81OXSR10.69956978
82PLK20.69725465
83CHEK10.69477970
84NEK10.66347677
85MAP3K80.65977440
86IRAK10.63232706
87LRRK20.63034984
88ARAF0.62184942
89CSNK1G20.60366409
90STK30.58911266
91CLK10.58055432
92PAK10.57694406
93MAPK110.57591048
94NME10.57248095
95PTK60.57193957
96PRKDC0.57009370
97MAP3K40.56666993
98BRAF0.56038769
99ALK0.55000981
100MARK10.53927219
101ILK0.53678039
102IRAK20.53024991
103PRKCG0.52788948
104CDK60.52420096
105BTK0.52046845
106PLK30.51804659
107YES10.51631571
108MAPK130.50939455
109DYRK1B0.50715252
110CDK20.50346035
111RPS6KA10.49368689
112CSNK2A20.49180404
113ABL20.48087565
114MELK0.47996644
115MAPKAPK50.47414788
116MAP2K20.46752029
117PINK10.45000521
118PRKD20.44325554
119CSNK1G30.44097290
120AKT10.42421267
121TESK10.42320945
122CDK10.41937917
123ATM0.40965545
124ZAK0.40415697
125FLT30.38956975
126RPS6KC10.38516381
127RPS6KL10.38516381
128PRKCI0.38420283
129BCR0.37717545
130NEK90.37592330
131PIM20.36635904
132ERBB20.36516150
133MAPK140.36243017
134CAMK2D0.35997873
135CDK120.35456588
136KSR10.33742634
137OBSCN0.33297057
138TSSK60.33126910
139MAP4K10.32499261
140MARK20.32383607
141EIF2AK30.32291571
142MAP3K120.32281899
143TEC0.32170183
144CAMK10.31633295
145CDK11A0.31068104
146RPS6KA60.30846317
147RPS6KA20.30104463
148KIT0.26441396
149PIM10.25327804
150EIF2AK20.25197911
151STK100.25193318
152MST40.25138815
153MAP2K70.24470952

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.92796365
2DNA replication_Homo sapiens_hsa030305.43490913
3Mismatch repair_Homo sapiens_hsa034304.56294573
4Spliceosome_Homo sapiens_hsa030403.89423265
5Butanoate metabolism_Homo sapiens_hsa006503.86100702
6Homologous recombination_Homo sapiens_hsa034403.81113491
7Base excision repair_Homo sapiens_hsa034103.38406989
8Nucleotide excision repair_Homo sapiens_hsa034203.30695187
9Proteasome_Homo sapiens_hsa030502.86768216
10RNA polymerase_Homo sapiens_hsa030202.75363183
11Pyrimidine metabolism_Homo sapiens_hsa002402.58289774
12Fanconi anemia pathway_Homo sapiens_hsa034602.57226031
13Cell cycle_Homo sapiens_hsa041102.34042875
14RNA transport_Homo sapiens_hsa030132.13729934
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06647514
16One carbon pool by folate_Homo sapiens_hsa006701.79849081
17RNA degradation_Homo sapiens_hsa030181.75487725
18Parkinsons disease_Homo sapiens_hsa050121.64890551
19Oxidative phosphorylation_Homo sapiens_hsa001901.50169095
20* Systemic lupus erythematosus_Homo sapiens_hsa053221.45754955
21Basal transcription factors_Homo sapiens_hsa030221.40159512
22Non-homologous end-joining_Homo sapiens_hsa034501.35953487
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35329214
24Huntingtons disease_Homo sapiens_hsa050161.34932322
25Purine metabolism_Homo sapiens_hsa002301.25787872
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24120784
27mRNA surveillance pathway_Homo sapiens_hsa030151.20747739
28p53 signaling pathway_Homo sapiens_hsa041151.20705740
29Protein export_Homo sapiens_hsa030601.09644347
30Steroid biosynthesis_Homo sapiens_hsa001001.01935982
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99973157
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97631834
33Axon guidance_Homo sapiens_hsa043600.95132996
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94057875
35Herpes simplex infection_Homo sapiens_hsa051680.88898447
36Alzheimers disease_Homo sapiens_hsa050100.88152640
37Sulfur relay system_Homo sapiens_hsa041220.86631113
38Folate biosynthesis_Homo sapiens_hsa007900.82940575
39Epstein-Barr virus infection_Homo sapiens_hsa051690.82740196
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82125926
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82125221
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80093561
43Primary immunodeficiency_Homo sapiens_hsa053400.79543960
44Dopaminergic synapse_Homo sapiens_hsa047280.77333826
45Basal cell carcinoma_Homo sapiens_hsa052170.76038333
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.75268452
47Cocaine addiction_Homo sapiens_hsa050300.74719592
48Notch signaling pathway_Homo sapiens_hsa043300.74182326
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.69833607
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68838790
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68159952
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67698576
53Pentose phosphate pathway_Homo sapiens_hsa000300.65862631
54Dilated cardiomyopathy_Homo sapiens_hsa054140.64293088
55Melanoma_Homo sapiens_hsa052180.64143614
56Fatty acid elongation_Homo sapiens_hsa000620.63398198
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63225175
58Olfactory transduction_Homo sapiens_hsa047400.59933586
59HTLV-I infection_Homo sapiens_hsa051660.59888516
60Melanogenesis_Homo sapiens_hsa049160.59097109
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59001212
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58188128
63Oocyte meiosis_Homo sapiens_hsa041140.57351819
64* Alcoholism_Homo sapiens_hsa050340.55794391
65Insulin secretion_Homo sapiens_hsa049110.55327106
66Pyruvate metabolism_Homo sapiens_hsa006200.53141386
67Fatty acid degradation_Homo sapiens_hsa000710.53003129
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48715404
69Cardiac muscle contraction_Homo sapiens_hsa042600.48242927
70Glutathione metabolism_Homo sapiens_hsa004800.47964968
71Biosynthesis of amino acids_Homo sapiens_hsa012300.47796071
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47494375
73Colorectal cancer_Homo sapiens_hsa052100.47025046
74Propanoate metabolism_Homo sapiens_hsa006400.46434729
75Vitamin B6 metabolism_Homo sapiens_hsa007500.46388532
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46356673
77Viral carcinogenesis_Homo sapiens_hsa052030.46270458
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46129688
79MicroRNAs in cancer_Homo sapiens_hsa052060.45571857
80Small cell lung cancer_Homo sapiens_hsa052220.44541220
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43452513
82Nicotine addiction_Homo sapiens_hsa050330.42322733
83Fatty acid metabolism_Homo sapiens_hsa012120.41347472
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41338516
85Antigen processing and presentation_Homo sapiens_hsa046120.40940895
86Glioma_Homo sapiens_hsa052140.40065046
87Morphine addiction_Homo sapiens_hsa050320.37122629
88Gap junction_Homo sapiens_hsa045400.37018381
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36206098
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35170688
91Pancreatic cancer_Homo sapiens_hsa052120.34284088
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32947136
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32786755
94Hedgehog signaling pathway_Homo sapiens_hsa043400.32723146
95Amphetamine addiction_Homo sapiens_hsa050310.32526927
96Glutamatergic synapse_Homo sapiens_hsa047240.32418463
97GABAergic synapse_Homo sapiens_hsa047270.32109764
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.31899706
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31360845
100Thyroid cancer_Homo sapiens_hsa052160.31172321
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31014951
102Metabolic pathways_Homo sapiens_hsa011000.30424506
103Circadian entrainment_Homo sapiens_hsa047130.29622207
104Selenocompound metabolism_Homo sapiens_hsa004500.29445879
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29135054
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29008223
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.27926134
108Bladder cancer_Homo sapiens_hsa052190.27443663
109Hippo signaling pathway_Homo sapiens_hsa043900.27200714
110Carbon metabolism_Homo sapiens_hsa012000.26990160
111Arachidonic acid metabolism_Homo sapiens_hsa005900.24516065
112Arginine and proline metabolism_Homo sapiens_hsa003300.23332371
113Apoptosis_Homo sapiens_hsa042100.22800162
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22248867
115Pathways in cancer_Homo sapiens_hsa052000.22218306
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.21318279
117N-Glycan biosynthesis_Homo sapiens_hsa005100.21227010
118Hepatitis B_Homo sapiens_hsa051610.20699134
119Galactose metabolism_Homo sapiens_hsa000520.19221948
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18499015
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18307729
122TGF-beta signaling pathway_Homo sapiens_hsa043500.16425172
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15132916
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13324083
125Measles_Homo sapiens_hsa051620.13217570
126Wnt signaling pathway_Homo sapiens_hsa043100.13135878
127Retinol metabolism_Homo sapiens_hsa008300.11738757
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11087004
129Legionellosis_Homo sapiens_hsa051340.10214968
130Non-small cell lung cancer_Homo sapiens_hsa052230.10064248
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.08321886
132Chronic myeloid leukemia_Homo sapiens_hsa052200.07744539
133Hematopoietic cell lineage_Homo sapiens_hsa046400.07660712
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05195438
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.04745966
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.04684977
137Renin-angiotensin system_Homo sapiens_hsa046140.03132762
138Influenza A_Homo sapiens_hsa051640.01686723

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