H1FX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)6.69097136
2paraxial mesoderm development (GO:0048339)4.24768991
3negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.23940873
4regulation of mammary gland epithelial cell proliferation (GO:0033599)4.20301058
5establishment of apical/basal cell polarity (GO:0035089)4.16054765
6pre-miRNA processing (GO:0031054)4.15789668
7planar cell polarity pathway involved in neural tube closure (GO:0090179)4.08834425
8cell migration in hindbrain (GO:0021535)3.93512942
9peptidyl-arginine omega-N-methylation (GO:0035247)3.84892803
10regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.79152104
11establishment or maintenance of monopolar cell polarity (GO:0061339)3.77044330
12establishment of monopolar cell polarity (GO:0061162)3.77044330
13negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.74461518
14apoptotic process involved in morphogenesis (GO:0060561)3.71190377
15lymph vessel development (GO:0001945)3.69312229
16response to muramyl dipeptide (GO:0032495)3.67815460
17polarized epithelial cell differentiation (GO:0030859)3.66685298
18regulation of posttranscriptional gene silencing (GO:0060147)3.66442977
19regulation of gene silencing by miRNA (GO:0060964)3.66442977
20regulation of gene silencing by RNA (GO:0060966)3.66442977
21positive thymic T cell selection (GO:0045059)3.65304078
22heterochromatin organization (GO:0070828)3.62140151
23viral transcription (GO:0019083)3.61162009
24nucleosome disassembly (GO:0006337)3.52613146
25protein-DNA complex disassembly (GO:0032986)3.52613146
26peptidyl-arginine methylation (GO:0018216)3.48380503
27peptidyl-arginine N-methylation (GO:0035246)3.48380503
28mannose metabolic process (GO:0006013)3.47882293
29regulation of response to osmotic stress (GO:0047484)3.47513796
30positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.45769510
31mitotic sister chromatid segregation (GO:0000070)3.44002800
32cellular hyperosmotic response (GO:0071474)3.42601857
33thymic T cell selection (GO:0045061)3.41177224
34translational termination (GO:0006415)3.34889684
35activation of MAPKKK activity (GO:0000185)3.33052442
36histone arginine methylation (GO:0034969)3.27915282
37modulation by virus of host process (GO:0019054)3.27116584
38sister chromatid segregation (GO:0000819)3.25920851
39spliceosomal tri-snRNP complex assembly (GO:0000244)3.23772441
40proximal/distal pattern formation (GO:0009954)3.23538528
41lateral sprouting from an epithelium (GO:0060601)3.23077593
42negative regulation of mRNA processing (GO:0050686)3.22156410
43regulation of stem cell maintenance (GO:2000036)3.20017962
44negative regulation of cell size (GO:0045792)3.19980178
45negative regulation of RNA splicing (GO:0033119)3.17517273
46cochlea morphogenesis (GO:0090103)3.16400863
47intracellular estrogen receptor signaling pathway (GO:0030520)3.14090009
48RNA stabilization (GO:0043489)3.09180435
49mRNA stabilization (GO:0048255)3.09180435
50embryonic process involved in female pregnancy (GO:0060136)3.07811969
51regulation of hippo signaling (GO:0035330)3.06190932
52DNA replication-dependent nucleosome assembly (GO:0006335)3.05700942
53DNA replication-dependent nucleosome organization (GO:0034723)3.05700942
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01555933
55DNA unwinding involved in DNA replication (GO:0006268)3.01482602
56protein localization to kinetochore (GO:0034501)3.01096666
57protein complex disassembly (GO:0043241)2.97658253
58establishment of planar polarity (GO:0001736)2.92539165
59establishment of tissue polarity (GO:0007164)2.92539165
60negative regulation of myotube differentiation (GO:0010832)2.91034847
61positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.89797324
62Peyers patch development (GO:0048541)2.89245590
63mucosal-associated lymphoid tissue development (GO:0048537)2.89245590
64positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88779530
65protein retention in ER lumen (GO:0006621)2.88204015
66modulation by symbiont of host cellular process (GO:0044068)2.87670099
67ribosomal small subunit biogenesis (GO:0042274)2.86568174
68osteoblast development (GO:0002076)2.86376479
69cellular protein complex disassembly (GO:0043624)2.84241518
70regulation of early endosome to late endosome transport (GO:2000641)2.83568068
71trophectodermal cell differentiation (GO:0001829)2.83294720
72histone H4-K12 acetylation (GO:0043983)2.82690121
73convergent extension (GO:0060026)2.82499186
74response to peptidoglycan (GO:0032494)2.82432592
75translational elongation (GO:0006414)2.82161491
76histone H3-K36 demethylation (GO:0070544)2.81891217
77microtubule depolymerization (GO:0007019)2.80231121
78positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.80115864
79cell-cell junction maintenance (GO:0045217)2.79782338
80peptidyl-lysine dimethylation (GO:0018027)2.79518064
81response to laminar fluid shear stress (GO:0034616)2.78995448
82positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.78276814
83regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.78276814
84entrainment of circadian clock by photoperiod (GO:0043153)2.77412337
85termination of RNA polymerase II transcription (GO:0006369)2.77310995
86translational initiation (GO:0006413)2.75886168
87positive regulation of histone deacetylation (GO:0031065)2.74813123
88spinal cord development (GO:0021510)2.74278328
89maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73177696
90macromolecular complex disassembly (GO:0032984)2.72393789
91regulation of monocyte differentiation (GO:0045655)2.71696691
92positive regulation by host of viral transcription (GO:0043923)2.71098822
93histone H3 deacetylation (GO:0070932)2.70659623
94negative regulation of mRNA metabolic process (GO:1903312)2.70576914
95poly(A)+ mRNA export from nucleus (GO:0016973)2.70397834
96negative regulation of granulocyte differentiation (GO:0030853)2.70017697
97anatomical structure regression (GO:0060033)2.69742077
983-UTR-mediated mRNA stabilization (GO:0070935)2.69157917
99mammary gland epithelial cell differentiation (GO:0060644)2.68878961
100regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.67291484
101protein localization to chromosome, centromeric region (GO:0071459)2.67088667
102establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.66876294
103outer ear morphogenesis (GO:0042473)2.66555192
104negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.66457174
105body morphogenesis (GO:0010171)2.65306590
106Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.64947402
107T cell selection (GO:0045058)2.64606075
108negative regulation of catenin import into nucleus (GO:0035414)2.63774133
109negative regulation of necroptotic process (GO:0060546)2.63240249
110layer formation in cerebral cortex (GO:0021819)2.62306100
111negative regulation of DNA repair (GO:0045738)2.62257408
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62029521
113regulation of histone H3-K27 methylation (GO:0061085)2.60602529
114histone H4-K5 acetylation (GO:0043981)2.60558170
115histone H4-K8 acetylation (GO:0043982)2.60558170
116apoptotic process involved in development (GO:1902742)2.59274525
117viral life cycle (GO:0019058)2.58623175
118pituitary gland development (GO:0021983)2.57865266
119negative regulation of skeletal muscle tissue development (GO:0048642)2.57734838
120head development (GO:0060322)2.57577692
121histone H4 deacetylation (GO:0070933)2.56690268
122maternal placenta development (GO:0001893)2.56193466
123regulation of leukocyte degranulation (GO:0043300)2.56174182
124embryonic foregut morphogenesis (GO:0048617)2.55899799
125UV protection (GO:0009650)2.55308774
126positive regulation of gamma-delta T cell activation (GO:0046645)2.54207823
127positive T cell selection (GO:0043368)2.53884981
128notochord development (GO:0030903)2.53428544
129regulation of establishment of planar polarity (GO:0090175)2.53135859
130regulation of apoptotic process involved in morphogenesis (GO:1902337)2.52945689
131nodal signaling pathway (GO:0038092)2.52478045
132negative regulation of striated muscle cell differentiation (GO:0051154)2.52264039
133spliceosomal snRNP assembly (GO:0000387)2.51004019
134spliceosomal complex assembly (GO:0000245)2.50906095
135chromatin assembly (GO:0031497)2.50739699
136mRNA splicing, via spliceosome (GO:0000398)2.50550948
137RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.50550948
138non-canonical Wnt signaling pathway (GO:0035567)2.50389779
139negative regulation of phagocytosis (GO:0050765)2.48683788
140ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.48652403
141activation of JUN kinase activity (GO:0007257)2.46668913
142negative regulation of cell aging (GO:0090344)2.46368145
143regulation of mRNA stability (GO:0043488)2.45983232
144RNA splicing, via transesterification reactions (GO:0000375)2.45257740
145protein targeting to plasma membrane (GO:0072661)2.44389529
146pentose-phosphate shunt (GO:0006098)2.44031356
147dosage compensation (GO:0007549)2.43404296
148DNA replication checkpoint (GO:0000076)2.42628894
149SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.41866787
150mitotic chromosome condensation (GO:0007076)2.41851848
151DNA strand elongation involved in DNA replication (GO:0006271)2.41845220
152regulation of NFAT protein import into nucleus (GO:0051532)2.40403135
153definitive hemopoiesis (GO:0060216)2.39293392
154leukocyte aggregation (GO:0070486)2.39144456
155regulation of chromatin binding (GO:0035561)2.38759418
156regulation of histone H3-K9 methylation (GO:0051570)2.38256217
157regulation of double-strand break repair (GO:2000779)2.38157530
158cellular response to virus (GO:0098586)2.38003443
159negative regulation of DNA-templated transcription, elongation (GO:0032785)2.37722459
160RNA localization (GO:0006403)2.37635630
161regulation of glucose import in response to insulin stimulus (GO:2001273)2.36147713
162neural tube closure (GO:0001843)2.36107399
163DNA replication initiation (GO:0006270)2.36014577
164negative regulation of interleukin-8 production (GO:0032717)2.35935239
165protein targeting to ER (GO:0045047)2.35592505
166negative regulation of B cell apoptotic process (GO:0002903)2.34761678
167maturation of SSU-rRNA (GO:0030490)2.33815328
168glial cell proliferation (GO:0014009)2.33434128
169cranial nerve morphogenesis (GO:0021602)2.33248096
170regulation of DNA damage checkpoint (GO:2000001)2.33025770
171negative regulation of glial cell proliferation (GO:0060253)2.31955279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.52209446
2* FOXM1_23109430_ChIP-Seq_U2OS_Human3.80639289
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.39255441
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.12789983
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.08058751
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.58580024
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.54754810
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32803448
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30364026
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29808167
11* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26982904
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.20417637
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.20417637
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.20417637
15VDR_24763502_ChIP-Seq_THP-1_Human2.20179139
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18163966
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.09734497
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.08417017
19ZFP281_27345836_Chip-Seq_ESCs_Mouse2.03961239
20RACK7_27058665_Chip-Seq_MCF-7_Human2.01544587
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01015505
22MYC_22102868_ChIP-Seq_BL_Human1.99701094
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95370493
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93640520
25* XRN2_22483619_ChIP-Seq_HELA_Human1.88901115
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.87148259
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86118385
28* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84898763
29UTX_26944678_Chip-Seq_JUKART_Human1.84355841
30MAF_26560356_Chip-Seq_TH1_Human1.80386828
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79260775
32SOX2_18555785_ChIP-Seq_MESCs_Mouse1.77993581
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.75806651
34* LXR_22292898_ChIP-Seq_THP-1_Human1.68592401
35KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.68452892
36VDR_21846776_ChIP-Seq_THP-1_Human1.66617650
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.65789173
38MAF_26560356_Chip-Seq_TH2_Human1.65282392
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64855986
40KDM2B_26808549_Chip-Seq_DND41_Human1.62786086
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58825515
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57780465
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56056657
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52174645
45POU5F1_16518401_ChIP-PET_MESCs_Mouse1.51021371
46SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.49618276
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48906681
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.48008277
49KDM2B_26808549_Chip-Seq_K562_Human1.47371512
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46792193
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46158836
52* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45182023
53NANOG_21062744_ChIP-ChIP_HESCs_Human1.44920070
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44518959
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.44295770
56EZH2_22144423_ChIP-Seq_EOC_Human1.42683348
57* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42496867
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41633756
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.41049614
60NCOR1_26117541_ChIP-Seq_K562_Human1.36135185
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.35789043
62TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35501654
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35298302
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34850664
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.34679149
66SCL_19346495_ChIP-Seq_HPC-7_Human1.34603655
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32450136
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32317034
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.31751829
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31721753
71* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31478747
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30537221
73SMC4_20622854_ChIP-Seq_HELA_Human1.29944813
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29573028
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29356232
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29332505
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28952647
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.27724692
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25673460
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.25097304
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24858467
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24173526
83TTF2_22483619_ChIP-Seq_HELA_Human1.23668526
84TCF7_22412390_ChIP-Seq_EML_Mouse1.23201539
85CREB1_26743006_Chip-Seq_LNCaP_Human1.22920424
86PKCTHETA_26484144_Chip-Seq_BREAST_Human1.22668107
87MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21871606
88CIITA_25753668_ChIP-Seq_RAJI_Human1.21844685
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20721632
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19182243
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18982745
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18912619
93NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18462046
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.18322397
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17871228
96BCOR_27268052_Chip-Seq_Bcells_Human1.16896521
97TET1_21451524_ChIP-Seq_MESCs_Mouse1.16389735
98EGR1_19374776_ChIP-ChIP_THP-1_Human1.14296006
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13675222
100CTCF_27219007_Chip-Seq_Bcells_Human1.13629265
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12184989
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12148370
103* BCL6_27268052_Chip-Seq_Bcells_Human1.12144547
104* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11960647
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11945207
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11887808
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11450634
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11398221
109OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11239962
110SOX2_16153702_ChIP-ChIP_HESCs_Human1.11202619
111TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10966765
112* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10710407
113SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10662745
114P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10391381
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10205250
116FOXP1_21924763_ChIP-Seq_HESCs_Human1.10096166
117MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09893866
118TP53_22127205_ChIP-Seq_IMR90_Human1.09049511
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08661871
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08523020
121SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08124469
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08032229
123CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07050680
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06538135
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06411170
126SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05907100
127POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05405696
128EZH2_27304074_Chip-Seq_ESCs_Mouse1.05169117
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05155607
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04595943
131CTCF_26484167_Chip-Seq_Bcells_Mouse1.04353310
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03736782
133ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03197449
134PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03100229
135* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01645801
136P68_20966046_ChIP-Seq_HELA_Human1.01539042
137MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01359535
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01287902
139E2F1_21310950_ChIP-Seq_MCF-7_Human1.01058789
140ZNF263_19887448_ChIP-Seq_K562_Human1.00929478
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00840184
142RING1B_27294783_Chip-Seq_ESCs_Mouse1.00113114
143CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99834179
144* CTCF_21964334_Chip-Seq_Bcells_Human0.99246400
145* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98642320
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.98385994
147SA1_27219007_Chip-Seq_ERYTHROID_Human0.97806244
148ETS1_21867929_ChIP-Seq_TH2_Mouse0.97339642
149RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97077555
150SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96527871
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.95901915
152PHF8_20622854_ChIP-Seq_HELA_Human0.95757968
153RUNX1_27514584_Chip-Seq_MCF-7_Human0.95675441
154ATF3_27146783_Chip-Seq_COLON_Human0.95032246
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92551656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.41016443
2MP0010030_abnormal_orbit_morphology3.25862209
3MP0004185_abnormal_adipocyte_glucose2.92012181
4MP0003303_peritoneal_inflammation2.68677306
5MP0002249_abnormal_larynx_morphology2.64633319
6MP0003123_paternal_imprinting2.50227586
7MP0000049_abnormal_middle_ear2.47141341
8MP0003119_abnormal_digestive_system2.44888163
9MP0002009_preneoplasia2.42649096
10MP0005623_abnormal_meninges_morphology2.36183512
11MP0005058_abnormal_lysosome_morphology2.35600991
12MP0003283_abnormal_digestive_organ2.30540009
13MP0006292_abnormal_olfactory_placode2.29108925
14MP0003436_decreased_susceptibility_to2.29013736
15MP0003122_maternal_imprinting2.28178049
16MP0004133_heterotaxia2.25415492
17MP0002877_abnormal_melanocyte_morpholog2.21441234
18MP0003111_abnormal_nucleus_morphology2.15554709
19MP0000537_abnormal_urethra_morphology2.14822019
20MP0003763_abnormal_thymus_physiology2.14803629
21MP0009053_abnormal_anal_canal2.08098873
22MP0003385_abnormal_body_wall2.05643771
23MP0002396_abnormal_hematopoietic_system2.03550568
24MP0001346_abnormal_lacrimal_gland1.95952849
25MP0005666_abnormal_adipose_tissue1.95757101
26MP0000681_abnormal_thyroid_gland1.94294799
27MP0003172_abnormal_lysosome_physiology1.86995588
28MP0004957_abnormal_blastocyst_morpholog1.86217521
29MP0009379_abnormal_foot_pigmentation1.85159891
30MP0003890_abnormal_embryonic-extraembry1.83593678
31MP0002282_abnormal_trachea_morphology1.80079466
32MP0005076_abnormal_cell_differentiation1.79777966
33MP0003077_abnormal_cell_cycle1.77629001
34MP0004808_abnormal_hematopoietic_stem1.77420492
35MP0002932_abnormal_joint_morphology1.77165190
36MP0005451_abnormal_body_composition1.74851981
37MP0000428_abnormal_craniofacial_morphol1.74637696
38MP0003942_abnormal_urinary_system1.74301469
39MP0002234_abnormal_pharynx_morphology1.73635939
40MP0002085_abnormal_embryonic_tissue1.70052579
41MP0003315_abnormal_perineum_morphology1.69789703
42MP0002084_abnormal_developmental_patter1.67623373
43MP0001545_abnormal_hematopoietic_system1.67071028
44MP0005397_hematopoietic_system_phenotyp1.67071028
45MP0008057_abnormal_DNA_replication1.67028631
46MP0008789_abnormal_olfactory_epithelium1.66745956
47MP0003861_abnormal_nervous_system1.66671416
48MP0005394_taste/olfaction_phenotype1.66526181
49MP0005499_abnormal_olfactory_system1.66526181
50MP0005409_darkened_coat_color1.66332353
51MP0003121_genomic_imprinting1.66037991
52MP0000703_abnormal_thymus_morphology1.64085049
53MP0003693_abnormal_embryo_hatching1.63003930
54MP0010094_abnormal_chromosome_stability1.59569453
55MP0003937_abnormal_limbs/digits/tail_de1.56519855
56MP0003115_abnormal_respiratory_system1.55052672
57MP0000678_abnormal_parathyroid_gland1.54771133
58MP0004197_abnormal_fetal_growth/weight/1.52850033
59MP0003938_abnormal_ear_development1.51585073
60MP0001293_anophthalmia1.51281834
61MP0003755_abnormal_palate_morphology1.50799903
62MP0002116_abnormal_craniofacial_bone1.49585026
63MP0003935_abnormal_craniofacial_develop1.49348339
64MP0003453_abnormal_keratinocyte_physiol1.47758334
65MP0002163_abnormal_gland_morphology1.46332187
66MP0003705_abnormal_hypodermis_morpholog1.45923009
67MP0000778_abnormal_nervous_system1.45535457
68MP0005375_adipose_tissue_phenotype1.45145332
69MP0004858_abnormal_nervous_system1.43039721
70MP0008932_abnormal_embryonic_tissue1.42382720
71MP0002398_abnormal_bone_marrow1.42338038
72MP0001348_abnormal_lacrimal_gland1.39849792
73MP0002751_abnormal_autonomic_nervous1.39046640
74MP0003300_gastrointestinal_ulcer1.37334026
75MP0001730_embryonic_growth_arrest1.33776203
76MP0000534_abnormal_ureter_morphology1.33268270
77MP0009333_abnormal_splenocyte_physiolog1.33208865
78MP0008260_abnormal_autophagy1.33022613
79MP0001672_abnormal_embryogenesis/_devel1.31398397
80MP0005380_embryogenesis_phenotype1.31398397
81MP0000350_abnormal_cell_proliferation1.31119123
82MP0002111_abnormal_tail_morphology1.31046926
83MP0005501_abnormal_skin_physiology1.28286431
84MP0004947_skin_inflammation1.27528631
85MP0002697_abnormal_eye_size1.26691020
86MP0002796_impaired_skin_barrier1.25310373
87MP0000566_synostosis1.25019086
88MP0009840_abnormal_foam_cell1.25014909
89MP0002114_abnormal_axial_skeleton1.24810434
90MP0002722_abnormal_immune_system1.23902454
91MP0001697_abnormal_embryo_size1.23850468
92MP0002092_abnormal_eye_morphology1.23310000
93MP0000685_abnormal_immune_system1.20918504
94MP0001502_abnormal_circadian_rhythm1.18933501
95MP0001188_hyperpigmentation1.17759612
96MP0000858_altered_metastatic_potential1.16328980
97MP0003567_abnormal_fetal_cardiomyocyte1.16311832
98MP0002233_abnormal_nose_morphology1.15855781
99MP0009250_abnormal_appendicular_skeleto1.14042586
100MP0004381_abnormal_hair_follicle1.13609398
101MP0000432_abnormal_head_morphology1.13184494
102MP0002420_abnormal_adaptive_immunity1.13036082
103MP0005025_abnormal_response_to1.12025986
104MP0000631_abnormal_neuroendocrine_gland1.10167769
105MP0001819_abnormal_immune_cell1.09586764
106MP0004859_abnormal_synaptic_plasticity1.09266843
107MP0002081_perinatal_lethality1.08600775
108MP0002080_prenatal_lethality1.06850605
109MP0000716_abnormal_immune_system1.06774364
110MP0002210_abnormal_sex_determination1.05858645
111MP0000955_abnormal_spinal_cord1.05714006
112MP0002152_abnormal_brain_morphology1.04732288
113MP0002088_abnormal_embryonic_growth/wei1.04282423
114MP0003984_embryonic_growth_retardation1.04211563
115MP0002429_abnormal_blood_cell1.03954694
116MP0009278_abnormal_bone_marrow1.03471652
117MP0001873_stomach_inflammation1.03138448
118MP0002098_abnormal_vibrissa_morphology1.02718099
119MP0001286_abnormal_eye_development1.01258450
120MP0001851_eye_inflammation1.00630649
121MP0000467_abnormal_esophagus_morphology1.00428473
122MP0001340_abnormal_eyelid_morphology0.99887585
123MP0001800_abnormal_humoral_immune0.98793879
124MP0004233_abnormal_muscle_weight0.98712763
125MP0001849_ear_inflammation0.97995331
126MP0004264_abnormal_extraembryonic_tissu0.97830242
127MP0005000_abnormal_immune_tolerance0.97741613
128MP0001145_abnormal_male_reproductive0.97390380
129MP0002086_abnormal_extraembryonic_tissu0.97177667
130MP0002419_abnormal_innate_immunity0.96930897
131MP0000490_abnormal_crypts_of0.96117044
132MP0000003_abnormal_adipose_tissue0.95625428
133MP0008877_abnormal_DNA_methylation0.95247794
134MP0009672_abnormal_birth_weight0.93719348
135MP0008961_abnormal_basal_metabolism0.93445358
136MP0008007_abnormal_cellular_replicative0.92640396
137MP0006072_abnormal_retinal_apoptosis0.91168119
138MP0000762_abnormal_tongue_morphology0.89515997
139MP0000689_abnormal_spleen_morphology0.89331271
140MP0009931_abnormal_skin_appearance0.89270777
141MP0001929_abnormal_gametogenesis0.88555073
142MP0002822_catalepsy0.88522556
143MP0005257_abnormal_intraocular_pressure0.88016596
144MP0002177_abnormal_outer_ear0.88004173
145MP0009703_decreased_birth_body0.87840362
146MP0000733_abnormal_muscle_development0.87054918
147MP0003329_amyloid_beta_deposits0.86859993
148MP0010630_abnormal_cardiac_muscle0.85215910
149MP0010234_abnormal_vibrissa_follicle0.84703879
150MP0005391_vision/eye_phenotype0.83991009
151MP0005464_abnormal_platelet_physiology0.83678493
152MP0002723_abnormal_immune_serum0.83060426
153MP0003698_abnormal_male_reproductive0.81201001
154MP0002452_abnormal_antigen_presenting0.81144738
155MP0002089_abnormal_postnatal_growth/wei0.80930694
156MP0004782_abnormal_surfactant_physiolog0.80343762
157MP0001270_distended_abdomen0.80075353
158MP0002938_white_spotting0.79484845
159MP0000313_abnormal_cell_death0.78756269
160MP0004510_myositis0.78444581
161MP0003191_abnormal_cellular_cholesterol0.78352881
162MP0004130_abnormal_muscle_cell0.77776131
163MP0003136_yellow_coat_color0.76672156
164MP0004885_abnormal_endolymph0.76190906
165MP0001853_heart_inflammation0.75875595
166MP0000462_abnormal_digestive_system0.75063603
167MP0001835_abnormal_antigen_presentation0.74859694
168MP0008770_decreased_survivor_rate0.74170340
169MP0003091_abnormal_cell_migration0.71972508
170MP0002405_respiratory_system_inflammati0.71725841
171MP0000477_abnormal_intestine_morphology0.67626713

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.60955311
2Renal duplication (HP:0000075)4.51833127
3Broad distal phalanx of finger (HP:0009836)3.62152820
4Abnormality of the lower motor neuron (HP:0002366)3.46570301
5Insomnia (HP:0100785)3.20612921
6Rib fusion (HP:0000902)3.13560071
7Overriding aorta (HP:0002623)3.05697993
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96710856
9Short 4th metacarpal (HP:0010044)2.96710856
10Renovascular hypertension (HP:0100817)2.95563022
11Abnormality of the fingertips (HP:0001211)2.93440186
12Hyperthyroidism (HP:0000836)2.86726063
13Concave nail (HP:0001598)2.80265613
14Increased nuchal translucency (HP:0010880)2.79825558
15Cellulitis (HP:0100658)2.76350799
16Abnormal number of incisors (HP:0011064)2.69786847
17Elfin facies (HP:0004428)2.67239302
18Abnormality of the aortic arch (HP:0012303)2.62589683
19Hypercortisolism (HP:0001578)2.60664760
20Germ cell neoplasia (HP:0100728)2.60078392
21Ulnar bowing (HP:0003031)2.59050548
22Abnormality of the thoracic spine (HP:0100711)2.58015075
23Broad face (HP:0000283)2.56946554
24Increased IgE level (HP:0003212)2.55304346
25Medulloblastoma (HP:0002885)2.55083254
26Polygenic inheritance (HP:0010982)2.49762087
27Thoracic kyphosis (HP:0002942)2.49254723
28Supernumerary spleens (HP:0009799)2.49000044
29Morphological abnormality of the middle ear (HP:0008609)2.48584810
30Long palpebral fissure (HP:0000637)2.47574010
31Supernumerary ribs (HP:0005815)2.47556147
32Selective tooth agenesis (HP:0001592)2.46818249
33Pointed chin (HP:0000307)2.45475984
34Abnormality of the 4th metacarpal (HP:0010012)2.45473191
35Abnormality of the diencephalon (HP:0010662)2.45366887
36Annular pancreas (HP:0001734)2.44806692
37Obstructive lung disease (HP:0006536)2.42358675
38Chronic obstructive pulmonary disease (HP:0006510)2.42358675
39Shallow orbits (HP:0000586)2.42083802
40Missing ribs (HP:0000921)2.37460712
41Broad alveolar ridges (HP:0000187)2.36607950
42Eczematoid dermatitis (HP:0000976)2.36012061
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.35035617
44Colon cancer (HP:0003003)2.34554421
45Flat cornea (HP:0007720)2.32393026
46Achilles tendon contracture (HP:0001771)2.32224850
47Bladder diverticulum (HP:0000015)2.29454493
48Colitis (HP:0002583)2.28093439
49Aplasia/Hypoplasia of the patella (HP:0006498)2.27326110
50Patellar aplasia (HP:0006443)2.26348899
51Ependymoma (HP:0002888)2.25971693
52Hypertensive crisis (HP:0100735)2.22199497
53Acute lymphatic leukemia (HP:0006721)2.21300922
54Disproportionate tall stature (HP:0001519)2.20402496
55Supernumerary bones of the axial skeleton (HP:0009144)2.19834153
56Abnormality of the columella (HP:0009929)2.19690161
57Abnormality of the distal phalanx of the thumb (HP:0009617)2.18478597
58Myopathic facies (HP:0002058)2.17985268
59Growth hormone excess (HP:0000845)2.16135953
60Agammaglobulinemia (HP:0004432)2.15846213
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15192921
62Hyperparathyroidism (HP:0000843)2.14019314
63Spina bifida occulta (HP:0003298)2.12909941
64Bronchomalacia (HP:0002780)2.12420343
65Generalized hypotonia (HP:0001290)2.11666481
66Bowel incontinence (HP:0002607)2.11361034
67Lower limb asymmetry (HP:0100559)2.10932895
68Gastrointestinal inflammation (HP:0004386)2.10850362
69Coronal craniosynostosis (HP:0004440)2.10161580
70Reticulocytopenia (HP:0001896)2.08982266
71Astrocytoma (HP:0009592)2.06122809
72Abnormality of the astrocytes (HP:0100707)2.06122809
73Abnormality of the labia minora (HP:0012880)2.05454675
74Arnold-Chiari malformation (HP:0002308)2.04255666
75Vertebral fusion (HP:0002948)2.03265870
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01938439
77Abnormal large intestine physiology (HP:0012700)2.00846050
78Syringomyelia (HP:0003396)2.00845168
79Spinal cord lesions (HP:0100561)2.00845168
80Stridor (HP:0010307)2.00529510
81Seborrheic dermatitis (HP:0001051)2.00443566
82Pseudobulbar signs (HP:0002200)1.99924290
83Patellar dislocation (HP:0002999)1.99744373
84Recurrent bacterial skin infections (HP:0005406)1.99160967
85Asymmetric growth (HP:0100555)1.98183312
86Tented upper lip vermilion (HP:0010804)1.97642016
87Bowel diverticulosis (HP:0005222)1.96186120
88Abnormality of cells of the erythroid lineage (HP:0012130)1.95773681
89Neoplasm of striated muscle (HP:0009728)1.95641850
90Broad thumb (HP:0011304)1.95572269
91Meningitis (HP:0001287)1.94731308
92Short phalanx of the thumb (HP:0009660)1.93848804
93Partial duplication of the phalanx of hand (HP:0009999)1.92945391
94Neoplasm of the heart (HP:0100544)1.92927000
95High anterior hairline (HP:0009890)1.91616487
96Broad palm (HP:0001169)1.91515846
97Abnormality of the Achilles tendon (HP:0005109)1.91465134
98Short 5th finger (HP:0009237)1.91043365
99Recurrent abscess formation (HP:0002722)1.90914280
100Large eyes (HP:0001090)1.90834318
101Abnormality of the phalanges of the hallux (HP:0010057)1.90169685
102Metaphyseal cupping (HP:0003021)1.90076453
103Thin ribs (HP:0000883)1.88951813
104Truncus arteriosus (HP:0001660)1.88895964
105Dislocated radial head (HP:0003083)1.88365016
106Abnormality of chromosome segregation (HP:0002916)1.87318244
107Reticulocytosis (HP:0001923)1.86936952
108Increased variability in muscle fiber diameter (HP:0003557)1.86660940
109Shawl scrotum (HP:0000049)1.86621087
110Abnormal ventriculo-arterial connection (HP:0011563)1.86279071
111Transposition of the great arteries (HP:0001669)1.86279071
112Abnormal connection of the cardiac segments (HP:0011545)1.86279071
113Aplasia/hypoplasia of the humerus (HP:0006507)1.86147916
114Megalocornea (HP:0000485)1.85630502
115Atresia of the external auditory canal (HP:0000413)1.85195308
116Turricephaly (HP:0000262)1.85103735
117Rectal prolapse (HP:0002035)1.85046487
118Ankyloglossia (HP:0010296)1.84533571
119Hepatoblastoma (HP:0002884)1.84108117
120Abnormality of the distal phalanges of the toes (HP:0010182)1.83648915
121Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.83098978
122Atelectasis (HP:0100750)1.82929082
123Distal lower limb amyotrophy (HP:0008944)1.82919317
124Facial hemangioma (HP:0000329)1.82491253
125Recurrent viral infections (HP:0004429)1.81916046
126Abnormality of the radial head (HP:0003995)1.79759328
127Easy fatigability (HP:0003388)1.79592919
128Panhypogammaglobulinemia (HP:0003139)1.79256698
129Asymmetry of the thorax (HP:0001555)1.78773327
130Overlapping toe (HP:0001845)1.78593874
131Amblyopia (HP:0000646)1.76840624
132Abnormality of the intervertebral disk (HP:0005108)1.76758785
133Bilateral microphthalmos (HP:0007633)1.76390570
134Hemivertebrae (HP:0002937)1.75868481
135Neoplasm of the oral cavity (HP:0100649)1.73111126
136Abnormality of abdominal situs (HP:0011620)1.72187637
137Abdominal situs inversus (HP:0003363)1.72187637
138Mediastinal lymphadenopathy (HP:0100721)1.71834684
139Esophageal atresia (HP:0002032)1.71755568
140Congenital diaphragmatic hernia (HP:0000776)1.71148342
141Nephroblastoma (Wilms tumor) (HP:0002667)1.70730622
142Genu recurvatum (HP:0002816)1.69836303
143Deviation of the hallux (HP:0010051)1.69148353
144Abnormality of reticulocytes (HP:0004312)1.69113903
145Double outlet right ventricle (HP:0001719)1.68628926
146Congenital malformation of the right heart (HP:0011723)1.68628926
147Hand muscle atrophy (HP:0009130)1.68010621
148Mitral regurgitation (HP:0001653)1.67573365
149Bulbar palsy (HP:0001283)1.66608534
150Hallux valgus (HP:0001822)1.66105298
151Segmental peripheral demyelination/remyelination (HP:0003481)1.65984081
152Obsessive-compulsive behavior (HP:0000722)1.65951736
153Inflammation of the large intestine (HP:0002037)1.64845306
154Skin tags (HP:0010609)1.64172862
155Hypoparathyroidism (HP:0000829)1.64097662
156Precocious puberty (HP:0000826)1.63986907
157Anophthalmia (HP:0000528)1.63901678
158Abnormal sex determination (HP:0012244)1.63857154
159Sex reversal (HP:0012245)1.63857154
160Broad phalanges of the hand (HP:0009768)1.63708884
161Deep palmar crease (HP:0006191)1.63360294
162Abnormality of skeletal muscle fiber size (HP:0012084)1.62982832
163Flat acetabular roof (HP:0003180)1.62906414
164Verrucae (HP:0200043)1.61935102
165Papilloma (HP:0012740)1.61935102
166Absent radius (HP:0003974)1.61728901
167Supernumerary nipples (HP:0002558)1.61722242
168Obstructive sleep apnea (HP:0002870)1.61446571
169Sacral dimple (HP:0000960)1.60820825
170Large earlobe (HP:0009748)1.60353249
171Aplasia/Hypoplasia of the thymus (HP:0010515)1.60119219
172Short humerus (HP:0005792)1.59786480
173Vertebral compression fractures (HP:0002953)1.59330994
174Abnormality of the parietal bone (HP:0002696)1.59222876
175Embryonal renal neoplasm (HP:0011794)1.58997236
176Aplasia involving forearm bones (HP:0009822)1.57644749
177Absent forearm bone (HP:0003953)1.57644749
178Viral hepatitis (HP:0006562)1.55864848
179Aplasia/Hypoplasia of the sternum (HP:0006714)1.55689894
180Supranuclear gaze palsy (HP:0000605)1.55578176
181J-shaped sella turcica (HP:0002680)1.55063399
182Flattened epiphyses (HP:0003071)1.54749089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.10177747
2ICK3.44374814
3SMG13.06201356
4TLK12.84737571
5CDK122.84175452
6CDC72.57100467
7ERN12.46845944
8PRKD32.34522425
9LATS22.32663746
10DYRK32.10060718
11SIK12.09596699
12TYRO32.09586376
13TRIB32.06518477
14UHMK11.92847782
15MAP4K11.89945767
16BUB11.89441834
17NME21.89363005
18MAP2K31.80959878
19MAP3K111.71199574
20EPHB21.71076692
21MKNK21.69911602
22TAOK21.65339357
23EEF2K1.62478620
24NEK21.58439586
25SRPK11.58123491
26HIPK21.56932233
27TTK1.56069642
28DDR21.49145878
29IRAK31.48588974
30PRKD21.46291205
31CDK71.39227443
32SIK21.38636022
33PDGFRA1.35690694
34MKNK11.34545071
35MARK11.30321463
36CHEK21.30153447
37PKN21.29596932
38DYRK1B1.27592412
39MAP2K21.27440227
40GRK61.26277869
41ARAF1.22567909
42PLK11.21774627
43MAP3K131.20855047
44FES1.20025713
45CDK41.19916346
46MAP3K11.18950542
47TAOK11.18880420
48WEE11.16755421
49ALK1.13580030
50MAP3K41.13245822
51IRAK21.11179974
52RPS6KC11.10320223
53RPS6KL11.10320223
54BMX1.08200365
55MAP3K91.06951244
56BRD41.05649688
57RIPK41.05351264
58MAP3K61.04198736
59RPS6KB21.02963484
60MTOR1.02295283
61BRAF1.01653049
62IRAK40.97951485
63RPS6KA20.97094952
64TNK20.96352601
65DYRK20.96019097
66AURKA0.88974782
67TBK10.88644891
68RPS6KA60.86916422
69SIK30.84722062
70LRRK20.84119251
71ILK0.83728562
72CHEK10.83663230
73BRSK10.83634666
74KSR20.83401981
75BTK0.83255371
76KSR10.80123615
77CDK60.79796838
78PDPK10.79219571
79MAPK110.78861057
80* CDK20.77302427
81RIPK10.76908090
82CDK11A0.76640105
83TESK20.76253933
84PAK40.74750665
85NEK10.74474574
86CDK150.74392191
87ATR0.74364619
88MAPK120.73062289
89TESK10.72774009
90MATK0.72304336
91CDK190.71964810
92CDK180.70933374
93FGFR40.70859079
94CAMKK10.70790892
95DAPK10.69681766
96ZAP700.69193855
97AURKB0.67741210
98PAK10.67078509
99TTN0.66870661
100PASK0.66514496
101CDK140.66379093
102MOS0.65763514
103MARK20.63941811
104RPS6KA10.63900174
105SCYL20.63634894
106KDR0.62446274
107CSNK1E0.62216195
108MAP3K20.61826189
109MINK10.61538442
110MARK30.61431468
111MAP3K30.60775390
112MAP3K80.60524953
113CDK10.60309138
114PTK60.59208407
115PDK10.59085939
116PAK60.58983359
117ERBB20.57916965
118PRKCI0.57465199
119MAP2K70.57229014
120PTK20.57199999
121RPS6KA40.55900345
122NTRK20.54122020
123CDK90.53230386
124EPHA40.52499872
125DAPK30.52497042
126AKT20.52188449
127HCK0.52181315
128NTRK10.52055660
129CLK10.52032590
130ATM0.51783487
131RET0.50306537
132LIMK10.50020216
133PAK20.49788115
134CDC42BPA0.46965459
135STK40.45816174
136PLK30.45716444
137MAPK40.45157125
138IKBKB0.45145054
139MAPK150.44295237
140TYK20.44260402
141PRKDC0.44071101
142PRPF4B0.43177741
143DAPK20.43119297
144DYRK1A0.43068131
145STK110.42431167
146CAMK40.42073421
147PNCK0.41321571
148CDK80.40928426
149MAPK70.40918135
150SGK30.40690105
151AKT10.33987310
152MAP3K140.33832711
153MAP3K70.33197687
154IKBKE0.33096586
155MAPK80.32992921
156CSF1R0.30821773
157ITK0.30266160
158CAMK1D0.30138453

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030403.18791959
2DNA replication_Homo sapiens_hsa030303.01701971
3Basal cell carcinoma_Homo sapiens_hsa052172.96283073
4Ribosome_Homo sapiens_hsa030102.84686240
5Hedgehog signaling pathway_Homo sapiens_hsa043402.71767528
6Mismatch repair_Homo sapiens_hsa034302.68681680
7B cell receptor signaling pathway_Homo sapiens_hsa046622.38509553
8mRNA surveillance pathway_Homo sapiens_hsa030152.35171009
9Other glycan degradation_Homo sapiens_hsa005112.21358770
10RNA transport_Homo sapiens_hsa030132.15339148
11Cell cycle_Homo sapiens_hsa041102.14939019
12Hippo signaling pathway_Homo sapiens_hsa043902.03876101
13Base excision repair_Homo sapiens_hsa034102.03003404
14Notch signaling pathway_Homo sapiens_hsa043302.00372345
15Homologous recombination_Homo sapiens_hsa034401.96326128
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.91987463
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.85812688
18Oocyte meiosis_Homo sapiens_hsa041141.82385588
19Wnt signaling pathway_Homo sapiens_hsa043101.71051775
20Bladder cancer_Homo sapiens_hsa052191.69645627
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.64740627
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64668676
23Melanogenesis_Homo sapiens_hsa049161.46199670
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41947500
25Nucleotide excision repair_Homo sapiens_hsa034201.40663528
26MicroRNAs in cancer_Homo sapiens_hsa052061.40015533
27Fanconi anemia pathway_Homo sapiens_hsa034601.38174041
28Osteoclast differentiation_Homo sapiens_hsa043801.37369628
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36383995
30T cell receptor signaling pathway_Homo sapiens_hsa046601.35169201
31Axon guidance_Homo sapiens_hsa043601.34921688
32Sulfur relay system_Homo sapiens_hsa041221.33604977
33Colorectal cancer_Homo sapiens_hsa052101.31743746
34Chronic myeloid leukemia_Homo sapiens_hsa052201.30789011
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29648957
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29458473
37Leishmaniasis_Homo sapiens_hsa051401.28933968
38Thyroid cancer_Homo sapiens_hsa052161.28743177
39Endometrial cancer_Homo sapiens_hsa052131.28601444
40Gap junction_Homo sapiens_hsa045401.26314827
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23225777
42One carbon pool by folate_Homo sapiens_hsa006701.20911900
43Glioma_Homo sapiens_hsa052141.20715109
44Hepatitis B_Homo sapiens_hsa051611.19770226
45Alcoholism_Homo sapiens_hsa050341.18969026
46Pentose phosphate pathway_Homo sapiens_hsa000301.18019938
47VEGF signaling pathway_Homo sapiens_hsa043701.17939313
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13752637
49Non-small cell lung cancer_Homo sapiens_hsa052231.11682777
50mTOR signaling pathway_Homo sapiens_hsa041501.07492484
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04746671
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.04227108
53ErbB signaling pathway_Homo sapiens_hsa040121.03762723
54RNA degradation_Homo sapiens_hsa030181.01597173
55Apoptosis_Homo sapiens_hsa042101.00640858
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00018464
57Herpes simplex infection_Homo sapiens_hsa051680.96987004
58HTLV-I infection_Homo sapiens_hsa051660.96509909
59Estrogen signaling pathway_Homo sapiens_hsa049150.95233864
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.93203501
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93071543
62FoxO signaling pathway_Homo sapiens_hsa040680.93044229
63Long-term potentiation_Homo sapiens_hsa047200.92153487
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91855988
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91609334
66Pathways in cancer_Homo sapiens_hsa052000.90677671
67GnRH signaling pathway_Homo sapiens_hsa049120.90292126
68Dorso-ventral axis formation_Homo sapiens_hsa043200.89612639
69Proteoglycans in cancer_Homo sapiens_hsa052050.89139500
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88221957
71Influenza A_Homo sapiens_hsa051640.86686168
72TGF-beta signaling pathway_Homo sapiens_hsa043500.86576891
73Tight junction_Homo sapiens_hsa045300.84374169
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83981387
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83830695
76Tuberculosis_Homo sapiens_hsa051520.82044612
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.79598313
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.78019132
79Inositol phosphate metabolism_Homo sapiens_hsa005620.77608690
80Dopaminergic synapse_Homo sapiens_hsa047280.76836454
81Systemic lupus erythematosus_Homo sapiens_hsa053220.76111348
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76034825
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75453063
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74768026
85Adherens junction_Homo sapiens_hsa045200.73395820
86Melanoma_Homo sapiens_hsa052180.72139784
87TNF signaling pathway_Homo sapiens_hsa046680.71970349
88Hepatitis C_Homo sapiens_hsa051600.71394194
89Toxoplasmosis_Homo sapiens_hsa051450.71325344
90Renal cell carcinoma_Homo sapiens_hsa052110.71129646
91Primary immunodeficiency_Homo sapiens_hsa053400.71102309
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69809783
93Lysine degradation_Homo sapiens_hsa003100.69803583
94Long-term depression_Homo sapiens_hsa047300.69712053
95Amphetamine addiction_Homo sapiens_hsa050310.69597014
96Small cell lung cancer_Homo sapiens_hsa052220.68326830
97HIF-1 signaling pathway_Homo sapiens_hsa040660.66668272
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.66452671
99p53 signaling pathway_Homo sapiens_hsa041150.66202998
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65452064
101Epstein-Barr virus infection_Homo sapiens_hsa051690.65431790
102Rap1 signaling pathway_Homo sapiens_hsa040150.64115319
103Viral carcinogenesis_Homo sapiens_hsa052030.63817920
104Chemokine signaling pathway_Homo sapiens_hsa040620.63784758
105Insulin signaling pathway_Homo sapiens_hsa049100.63189753
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63037265
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.62544654
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62451295
109Endocytosis_Homo sapiens_hsa041440.62154029
110Measles_Homo sapiens_hsa051620.61353497
111Viral myocarditis_Homo sapiens_hsa054160.60409490
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.58496699
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57333050
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56372627
115Glutamatergic synapse_Homo sapiens_hsa047240.55732852
116Focal adhesion_Homo sapiens_hsa045100.55323455
117Acute myeloid leukemia_Homo sapiens_hsa052210.55286160
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.54953923
119Salmonella infection_Homo sapiens_hsa051320.54855348
120Shigellosis_Homo sapiens_hsa051310.54137377
121RNA polymerase_Homo sapiens_hsa030200.53006100
122Cocaine addiction_Homo sapiens_hsa050300.52725636
123Type II diabetes mellitus_Homo sapiens_hsa049300.52571563
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.52457565
125Pyrimidine metabolism_Homo sapiens_hsa002400.51885350
126Oxytocin signaling pathway_Homo sapiens_hsa049210.51537177
127Insulin resistance_Homo sapiens_hsa049310.51215219
128Prostate cancer_Homo sapiens_hsa052150.50579244
129Circadian entrainment_Homo sapiens_hsa047130.50001028
130MAPK signaling pathway_Homo sapiens_hsa040100.49201958
131Platelet activation_Homo sapiens_hsa046110.48940571
132Basal transcription factors_Homo sapiens_hsa030220.48610247
133Amoebiasis_Homo sapiens_hsa051460.48030675
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47980691
135Choline metabolism in cancer_Homo sapiens_hsa052310.47827582
136Olfactory transduction_Homo sapiens_hsa047400.47368750
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45587067
138Glucagon signaling pathway_Homo sapiens_hsa049220.43766857
139Pancreatic cancer_Homo sapiens_hsa052120.41963975
140AMPK signaling pathway_Homo sapiens_hsa041520.41343982
141Prolactin signaling pathway_Homo sapiens_hsa049170.40144686
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39645959
143Prion diseases_Homo sapiens_hsa050200.36659191
144Ras signaling pathway_Homo sapiens_hsa040140.36461166
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36377576
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35339508
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35290019

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