H1F0

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.66238030
2Golgi transport vesicle coating (GO:0048200)4.66238030
3protoporphyrinogen IX metabolic process (GO:0046501)4.56463580
4very-low-density lipoprotein particle assembly (GO:0034379)4.44718832
5exocrine pancreas development (GO:0031017)4.39792664
6hemoglobin metabolic process (GO:0020027)3.84777627
7plasma lipoprotein particle assembly (GO:0034377)3.80450215
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.76587657
9proline biosynthetic process (GO:0006561)3.75241224
10desmosome organization (GO:0002934)3.72711594
11negative regulation of fibrinolysis (GO:0051918)3.72009251
12planar cell polarity pathway involved in neural tube closure (GO:0090179)3.65949409
13protein-lipid complex assembly (GO:0065005)3.63369718
14protein retention in ER lumen (GO:0006621)3.60862547
15protoporphyrinogen IX biosynthetic process (GO:0006782)3.60669090
16cytoskeletal anchoring at plasma membrane (GO:0007016)3.57733989
17regulation of response to osmotic stress (GO:0047484)3.54026202
18midgut development (GO:0007494)3.48845592
19embryonic process involved in female pregnancy (GO:0060136)3.45075402
204-hydroxyproline metabolic process (GO:0019471)3.43094736
21polarized epithelial cell differentiation (GO:0030859)3.41831553
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.41122418
23regulation of cardioblast proliferation (GO:0003264)3.30110740
24regulation of secondary heart field cardioblast proliferation (GO:0003266)3.30110740
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.27586553
26protein carboxylation (GO:0018214)3.25505301
27peptidyl-glutamic acid carboxylation (GO:0017187)3.25505301
28positive regulation of fatty acid beta-oxidation (GO:0032000)3.25201918
29embryonic foregut morphogenesis (GO:0048617)3.20954507
30G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.17482244
31proline metabolic process (GO:0006560)3.14715315
32regulation of fatty acid beta-oxidation (GO:0031998)3.09573770
33dorsal/ventral axis specification (GO:0009950)3.03550783
34hippo signaling (GO:0035329)3.03386645
35epithelial cell-cell adhesion (GO:0090136)3.00582711
36nephron tubule formation (GO:0072079)3.00029532
37regulation of fibrinolysis (GO:0051917)2.99868566
38renal system development (GO:0072001)2.99459856
39regulation of heart morphogenesis (GO:2000826)2.97078815
40lysine metabolic process (GO:0006553)2.95055113
41lysine catabolic process (GO:0006554)2.95055113
42positive regulation of glycogen biosynthetic process (GO:0045725)2.94849167
43intestinal cholesterol absorption (GO:0030299)2.94146998
44activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.93904919
45regulation of cholesterol biosynthetic process (GO:0045540)2.93298943
46negative regulation of erythrocyte differentiation (GO:0045647)2.92738874
47epithelial cell differentiation involved in prostate gland development (GO:0060742)2.91292216
48insulin-like growth factor receptor signaling pathway (GO:0048009)2.91184993
49positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.91140558
50cell-cell junction maintenance (GO:0045217)2.89559581
51cochlea morphogenesis (GO:0090103)2.88409695
52glucose 6-phosphate metabolic process (GO:0051156)2.88363628
53positive regulation of nuclease activity (GO:0032075)2.87289347
54outer ear morphogenesis (GO:0042473)2.87093662
55basement membrane organization (GO:0071711)2.85927365
56maternal placenta development (GO:0001893)2.85521757
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82011397
58L-phenylalanine metabolic process (GO:0006558)2.82011397
59porphyrin-containing compound biosynthetic process (GO:0006779)2.81527668
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.78257933
61L-phenylalanine catabolic process (GO:0006559)2.78257933
62regulation of cholesterol esterification (GO:0010872)2.77164352
63negative regulation of catenin import into nucleus (GO:0035414)2.76288636
64protein heterotrimerization (GO:0070208)2.72250008
65neuron projection extension involved in neuron projection guidance (GO:1902284)2.71698758
66axon extension involved in axon guidance (GO:0048846)2.71698758
67mesenchyme morphogenesis (GO:0072132)2.71613857
68mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.71210503
69positive regulation of extracellular matrix organization (GO:1903055)2.70781316
70RNA localization (GO:0006403)2.70535251
71low-density lipoprotein particle remodeling (GO:0034374)2.70051872
72hemidesmosome assembly (GO:0031581)2.69023818
73bundle of His cell to Purkinje myocyte communication (GO:0086069)2.68457539
74regulation of cholesterol homeostasis (GO:2000188)2.65293616
75endocardial cushion development (GO:0003197)2.64824922
76establishment of apical/basal cell polarity (GO:0035089)2.64626972
77positive regulation of hormone biosynthetic process (GO:0046886)2.64077675
78Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.63557542
79COPII vesicle coating (GO:0048208)2.62797892
80cellular response to prostaglandin stimulus (GO:0071379)2.61296082
81gastrulation with mouth forming second (GO:0001702)2.59855899
82skin morphogenesis (GO:0043589)2.59077186
83positive regulation of fatty acid biosynthetic process (GO:0045723)2.58957433
84regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.58595599
85alpha-linolenic acid metabolic process (GO:0036109)2.58508476
86endocardial cushion morphogenesis (GO:0003203)2.57957238
87endoplasmic reticulum unfolded protein response (GO:0030968)2.57739594
88receptor recycling (GO:0001881)2.57544233
89branching involved in mammary gland duct morphogenesis (GO:0060444)2.57106299
90plasma lipoprotein particle organization (GO:0071827)2.56739664
91regulation of bile acid biosynthetic process (GO:0070857)2.56700074
92regulation of fatty acid biosynthetic process (GO:0042304)2.56591014
93regulation of protein activation cascade (GO:2000257)2.56133506
94regulation of apoptotic cell clearance (GO:2000425)2.56103762
953-UTR-mediated mRNA stabilization (GO:0070935)2.55165523
96protein-lipid complex subunit organization (GO:0071825)2.54920638
97negative regulation of fatty acid transport (GO:2000192)2.54887366
98barbed-end actin filament capping (GO:0051016)2.54586831
99collagen fibril organization (GO:0030199)2.54307023
100intestinal absorption (GO:0050892)2.54036939
101positive regulation of fatty acid oxidation (GO:0046321)2.53761050
102retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53454720
103regulation of establishment of planar polarity (GO:0090175)2.52897280
104semaphorin-plexin signaling pathway (GO:0071526)2.52719479
105regulation of complement activation (GO:0030449)2.51536950
106positive regulation of hormone metabolic process (GO:0032352)2.51024478
107definitive hemopoiesis (GO:0060216)2.50521364
108negative regulation of cell size (GO:0045792)2.49986378
109protein-DNA complex disassembly (GO:0032986)2.49924225
110nucleosome disassembly (GO:0006337)2.49924225
111lung epithelium development (GO:0060428)2.49917587
112regulation of nuclease activity (GO:0032069)2.48630967
113endocrine pancreas development (GO:0031018)2.48491581
114non-canonical Wnt signaling pathway (GO:0035567)2.47660032
115positive regulation of glycogen metabolic process (GO:0070875)2.47179558
116collecting duct development (GO:0072044)2.45259067
117regulation of plasminogen activation (GO:0010755)2.44608886
118negative regulation of fatty acid biosynthetic process (GO:0045717)2.44224246
119ER-nucleus signaling pathway (GO:0006984)2.44122400
120type B pancreatic cell development (GO:0003323)2.43023091
121positive regulation of gastrulation (GO:2000543)2.42348545
122cell proliferation involved in metanephros development (GO:0072203)2.42229946
123cellular response to unfolded protein (GO:0034620)2.42018881
124branching involved in salivary gland morphogenesis (GO:0060445)2.41904915
125embryonic retina morphogenesis in camera-type eye (GO:0060059)2.41851088
126peptidyl-lysine dimethylation (GO:0018027)2.41612224
127cell-substrate adherens junction assembly (GO:0007045)2.41073202
128focal adhesion assembly (GO:0048041)2.41073202
129blood coagulation, intrinsic pathway (GO:0007597)2.40647333
130cell junction maintenance (GO:0034331)2.40606539
131layer formation in cerebral cortex (GO:0021819)2.40181754
132negative regulation of chondrocyte differentiation (GO:0032331)2.40180129
133adherens junction assembly (GO:0034333)2.39858483
134mitotic chromosome condensation (GO:0007076)2.39252351
135establishment of tissue polarity (GO:0007164)2.38979457
136establishment of planar polarity (GO:0001736)2.38979457
137convergent extension (GO:0060026)2.38630080
138low-density lipoprotein particle clearance (GO:0034383)2.38323430
139porphyrin-containing compound metabolic process (GO:0006778)2.37550937
140paraxial mesoderm development (GO:0048339)2.37292447
141protein localization to endosome (GO:0036010)2.36738098
142glyoxylate metabolic process (GO:0046487)2.36724861
143positive regulation of mesenchymal cell proliferation (GO:0002053)2.36642567
144lateral sprouting from an epithelium (GO:0060601)2.36549811
145protein-lipid complex remodeling (GO:0034368)2.36539036
146macromolecular complex remodeling (GO:0034367)2.36539036
147plasma lipoprotein particle remodeling (GO:0034369)2.36539036
148cell migration involved in sprouting angiogenesis (GO:0002042)2.36512429
149positive regulation of triglyceride lipase activity (GO:0061365)2.36422089
150positive regulation of lipoprotein lipase activity (GO:0051006)2.36422089
151regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.35898300
152regulation of cardioblast differentiation (GO:0051890)2.35896148
153regulation of RNA export from nucleus (GO:0046831)2.34660725
154regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.34408314
155activation of Rac GTPase activity (GO:0032863)2.34222962
156mRNA stabilization (GO:0048255)2.33988773
157RNA stabilization (GO:0043489)2.33988773
158mesenchymal cell proliferation (GO:0010463)2.33594273
159dopaminergic neuron differentiation (GO:0071542)2.33165610
160regulation of extracellular matrix organization (GO:1903053)2.33116222
161embryonic camera-type eye morphogenesis (GO:0048596)2.32389495
162regulation of glucose import in response to insulin stimulus (GO:2001273)2.32027160
163cysteine metabolic process (GO:0006534)2.31762271
164epithelial cell fate commitment (GO:0072148)2.31707461
165glial cell proliferation (GO:0014009)2.31610468
166embryonic eye morphogenesis (GO:0048048)2.30892968
167protein targeting to plasma membrane (GO:0072661)2.30848160
168pinocytosis (GO:0006907)2.30275556
169glandular epithelial cell development (GO:0002068)2.30189751
170cellular response to epidermal growth factor stimulus (GO:0071364)2.30131322
171maintenance of protein localization in organelle (GO:0072595)2.30102080
172sulfur amino acid catabolic process (GO:0000098)2.30045451
173glandular epithelial cell differentiation (GO:0002067)2.29902771
174anatomical structure regression (GO:0060033)2.27486447
175pattern specification involved in kidney development (GO:0061004)2.26194075
176ectoderm development (GO:0007398)2.25812421
177endothelial cell morphogenesis (GO:0001886)2.24988597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.02789048
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.99588788
3* CLOCK_20551151_ChIP-Seq_293T_Human3.30295959
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.01081344
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.92138201
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.86170228
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.83944295
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.77933985
9* RXR_22158963_ChIP-Seq_LIVER_Mouse2.74809439
10ZNF263_19887448_ChIP-Seq_K562_Human2.62314155
11* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.59431754
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54895657
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52132176
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43831435
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33456777
16* LXR_22158963_ChIP-Seq_LIVER_Mouse2.32019451
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.07996933
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97048431
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.89050192
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88153778
21* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76077359
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.74262886
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68046500
24* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67754828
25* RACK7_27058665_Chip-Seq_MCF-7_Human1.65539162
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.64367665
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.63119314
28P300_27058665_Chip-Seq_ZR-75-30cells_Human1.62389684
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61569596
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.59768509
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.59701867
32* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58418780
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58180629
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55670470
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54460877
36LXR_22292898_ChIP-Seq_THP-1_Human1.54104480
37NFIB_24661679_ChIP-Seq_LUNG_Mouse1.53502099
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.53022706
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51830168
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51524917
41ATF3_27146783_Chip-Seq_COLON_Human1.51493715
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49841255
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.48661548
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46452214
45* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46133533
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45008164
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44906619
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43486264
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42759390
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42550896
51VDR_21846776_ChIP-Seq_THP-1_Human1.41193808
52CREB1_26743006_Chip-Seq_LNCaP_Human1.40479005
53ISL1_27105846_Chip-Seq_CPCs_Mouse1.39175680
54KDM2B_26808549_Chip-Seq_K562_Human1.36784838
55AR_21909140_ChIP-Seq_LNCAP_Human1.35458984
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.35304722
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34922445
58* GATA6_25053715_ChIP-Seq_YYC3_Human1.34276453
59* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34105873
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32630661
61GATA1_19941826_ChIP-Seq_K562_Human1.32408581
62KDM2B_26808549_Chip-Seq_DND41_Human1.31992755
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31280286
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31010143
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30856259
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.30491873
67FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.30173250
68CHD1_26751641_Chip-Seq_LNCaP_Human1.29055851
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29036570
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27332390
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27116361
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.26870584
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.26870584
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.26360553
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.25929550
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25403883
77* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23905134
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23505190
79TP53_22127205_ChIP-Seq_IMR90_Human1.23313540
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22305883
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22082137
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.19548113
83* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19359733
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18707404
85FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18518150
86* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18229035
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17585442
88* FOXO3_23340844_ChIP-Seq_DLD1_Human1.17301280
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17291378
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16698153
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16369068
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.16096806
93GATA4_25053715_ChIP-Seq_YYC3_Human1.15495102
94FOXA2_19822575_ChIP-Seq_HepG2_Human1.15068871
95P68_20966046_ChIP-Seq_HELA_Human1.14132599
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13524820
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.13460258
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.13017351
99NCOR1_26117541_ChIP-Seq_K562_Human1.12074452
100* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10323165
101* TCF7_22412390_ChIP-Seq_EML_Mouse1.09532725
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08906600
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07877384
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07655393
105* TET1_21451524_ChIP-Seq_MESCs_Mouse1.07355889
106EP300_21415370_ChIP-Seq_HL-1_Mouse1.05673500
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05635194
108SOX2_20726797_ChIP-Seq_SW620_Human1.05407592
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03880279
110* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03032991
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02550830
112SMC4_20622854_ChIP-Seq_HELA_Human1.02052606
113SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01061600
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00634232
115SA1_27219007_Chip-Seq_ERYTHROID_Human0.99403747
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99153444
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98589094
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98412302
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.97600858
120EED_16625203_ChIP-ChIP_MESCs_Mouse0.96882375
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96833129
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92392628
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92309442
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91328355
125EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90615289
126PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89807499
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88654660
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88206461
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87851835
130MYC_22102868_ChIP-Seq_BL_Human0.87449430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.79392552
2MP0003656_abnormal_erythrocyte_physiolo3.23584581
3MP0000537_abnormal_urethra_morphology2.98309352
4MP0003283_abnormal_digestive_organ2.97280103
5MP0010030_abnormal_orbit_morphology2.92091217
6MP0008438_abnormal_cutaneous_collagen2.87821033
7MP0004147_increased_porphyrin_level2.78709406
8MP0010234_abnormal_vibrissa_follicle2.73053104
9MP0009053_abnormal_anal_canal2.59001729
10MP0005409_darkened_coat_color2.36573817
11MP0002234_abnormal_pharynx_morphology2.35365879
12MP0004272_abnormal_basement_membrane2.33364828
13MP0002139_abnormal_hepatobiliary_system2.29822837
14MP0006054_spinal_hemorrhage2.18296440
15MP0005503_abnormal_tendon_morphology2.05613052
16MP0005360_urolithiasis2.01529321
17MP0002877_abnormal_melanocyte_morpholog1.99469894
18MP0005275_abnormal_skin_tensile1.97753245
19MP0005187_abnormal_penis_morphology1.92304384
20MP0005501_abnormal_skin_physiology1.90609161
21MP0005220_abnormal_exocrine_pancreas1.90487900
22MP0005451_abnormal_body_composition1.86806420
23MP0001666_abnormal_nutrient_absorption1.83384761
24MP0005365_abnormal_bile_salt1.78411387
25MP0005058_abnormal_lysosome_morphology1.76609534
26MP0005083_abnormal_biliary_tract1.76273442
27MP0003191_abnormal_cellular_cholesterol1.65922430
28MP0003942_abnormal_urinary_system1.65478538
29MP0004858_abnormal_nervous_system1.65461932
30MP0000462_abnormal_digestive_system1.65084175
31MP0001849_ear_inflammation1.62288244
32MP0003252_abnormal_bile_duct1.59687152
33MP0005666_abnormal_adipose_tissue1.58724112
34MP0009840_abnormal_foam_cell1.53479705
35MP0009384_cardiac_valve_regurgitation1.51828423
36MP0002896_abnormal_bone_mineralization1.50603475
37MP0000534_abnormal_ureter_morphology1.49098844
38MP0000733_abnormal_muscle_development1.48533056
39MP0005076_abnormal_cell_differentiation1.48513377
40MP0003115_abnormal_respiratory_system1.44824218
41MP0010678_abnormal_skin_adnexa1.44813742
42MP0005085_abnormal_gallbladder_physiolo1.42221536
43MP0003123_paternal_imprinting1.42017284
44MP0003385_abnormal_body_wall1.40925524
45MP0002932_abnormal_joint_morphology1.40230396
46MP0005623_abnormal_meninges_morphology1.39949992
47MP0003119_abnormal_digestive_system1.38327280
48MP0010368_abnormal_lymphatic_system1.38243735
49MP0000428_abnormal_craniofacial_morphol1.37583344
50MP0000049_abnormal_middle_ear1.33115004
51MP0009250_abnormal_appendicular_skeleto1.31767065
52MP0005248_abnormal_Harderian_gland1.31518055
53MP0003122_maternal_imprinting1.29551102
54MP0002938_white_spotting1.28700271
55MP0004782_abnormal_surfactant_physiolog1.28120267
56MP0003937_abnormal_limbs/digits/tail_de1.27737889
57MP0002697_abnormal_eye_size1.23194071
58MP0000566_synostosis1.23007515
59MP0002282_abnormal_trachea_morphology1.22497391
60MP0003300_gastrointestinal_ulcer1.22209361
61MP0002098_abnormal_vibrissa_morphology1.21925128
62MP0000678_abnormal_parathyroid_gland1.21598143
63MP0002249_abnormal_larynx_morphology1.18957482
64MP0002233_abnormal_nose_morphology1.18107463
65MP0000003_abnormal_adipose_tissue1.17277742
66MP0000467_abnormal_esophagus_morphology1.16744605
67MP0000579_abnormal_nail_morphology1.15481985
68MP0001299_abnormal_eye_distance/1.14998022
69MP0003329_amyloid_beta_deposits1.14970784
70MP0000762_abnormal_tongue_morphology1.14967117
71MP0001270_distended_abdomen1.14664416
72MP0002060_abnormal_skin_morphology1.14136621
73MP0003935_abnormal_craniofacial_develop1.13732880
74MP0005257_abnormal_intraocular_pressure1.12646754
75MP0001944_abnormal_pancreas_morphology1.10659455
76MP0001346_abnormal_lacrimal_gland1.10626966
77MP0005508_abnormal_skeleton_morphology1.10348668
78MP0000383_abnormal_hair_follicle1.09495759
79MP0004264_abnormal_extraembryonic_tissu1.07099092
80MP0010630_abnormal_cardiac_muscle1.07054801
81MP0008260_abnormal_autophagy1.06666949
82MP0002092_abnormal_eye_morphology1.06289955
83MP0003755_abnormal_palate_morphology1.04650980
84MP0009278_abnormal_bone_marrow1.02633583
85MP0005670_abnormal_white_adipose1.00956224
86MP0001730_embryonic_growth_arrest1.00499393
87MP0001915_intracranial_hemorrhage0.99050949
88MP0000647_abnormal_sebaceous_gland0.98953806
89MP0004185_abnormal_adipocyte_glucose0.98120433
90MP0002009_preneoplasia0.98115221
91MP0008961_abnormal_basal_metabolism0.97061117
92MP0002116_abnormal_craniofacial_bone0.96228471
93MP0009780_abnormal_chondrocyte_physiolo0.96123576
94MP0000163_abnormal_cartilage_morphology0.95689517
95MP0003566_abnormal_cell_adhesion0.94525649
96MP0001216_abnormal_epidermal_layer0.94097280
97MP0009931_abnormal_skin_appearance0.93136235
98MP0003195_calcinosis0.92752509
99MP0000377_abnormal_hair_follicle0.92736909
100MP0000013_abnormal_adipose_tissue0.92648817
101MP0002111_abnormal_tail_morphology0.90848865
102MP0004197_abnormal_fetal_growth/weight/0.89533950
103MP0002086_abnormal_extraembryonic_tissu0.88541598
104MP0001958_emphysema0.86728527
105MP0005408_hypopigmentation0.86569024
106MP0004233_abnormal_muscle_weight0.86398328
107MP0005023_abnormal_wound_healing0.86182979
108MP0002089_abnormal_postnatal_growth/wei0.86135980
109MP0010329_abnormal_lipoprotein_level0.85357796
110MP0000613_abnormal_salivary_gland0.84804747
111MP0005375_adipose_tissue_phenotype0.84787003
112MP0009672_abnormal_birth_weight0.84489878
113MP0001293_anophthalmia0.83698332
114MP0003453_abnormal_keratinocyte_physiol0.83593105
115MP0003567_abnormal_fetal_cardiomyocyte0.83498998
116MP0003868_abnormal_feces_composition0.83017235
117MP0010771_integument_phenotype0.82668755
118MP0003984_embryonic_growth_retardation0.81063308
119MP0006138_congestive_heart_failure0.80318808
120MP0004087_abnormal_muscle_fiber0.79859339
121MP0008789_abnormal_olfactory_epithelium0.79506042
122MP0003315_abnormal_perineum_morphology0.79397430
123* MP0002080_prenatal_lethality0.79128323
124MP0000432_abnormal_head_morphology0.79123007
125MP0000609_abnormal_liver_physiology0.78717946
126MP0002796_impaired_skin_barrier0.78588005
127MP0002115_abnormal_skeleton_extremities0.77895279
128MP0001340_abnormal_eyelid_morphology0.76610417
129MP0002088_abnormal_embryonic_growth/wei0.76276954
130MP0001672_abnormal_embryogenesis/_devel0.76254823
131MP0005380_embryogenesis_phenotype0.76254823
132MP0002084_abnormal_developmental_patter0.76079076
133MP0003172_abnormal_lysosome_physiology0.74705107
134MP0005636_abnormal_mineral_homeostasis0.72710865
135MP0010352_gastrointestinal_tract_polyps0.70552946
136MP0000627_abnormal_mammary_gland0.68809729
137MP0000681_abnormal_thyroid_gland0.68380529
138MP0003943_abnormal_hepatobiliary_system0.67717701
139MP0000477_abnormal_intestine_morphology0.67676874
140MP0004808_abnormal_hematopoietic_stem0.67134533

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.08915958
2Shallow orbits (HP:0000586)3.73505231
3Flat acetabular roof (HP:0003180)3.65920668
4Premature rupture of membranes (HP:0001788)3.55164203
5Reticulocytosis (HP:0001923)3.31412961
6Renal duplication (HP:0000075)3.02304238
7Abnormality of the heme biosynthetic pathway (HP:0010472)3.00321518
8Ankle contracture (HP:0006466)2.93113392
9Broad metatarsal (HP:0001783)2.92030442
10Abnormality of carpal bone ossification (HP:0006257)2.91840754
11Poikilocytosis (HP:0004447)2.90174192
12Short 4th metacarpal (HP:0010044)2.89517451
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.89517451
14Lymphangioma (HP:0100764)2.86206956
15Atrophic scars (HP:0001075)2.85571326
16Abnormality of the 4th metacarpal (HP:0010012)2.78726266
17Bladder diverticulum (HP:0000015)2.78006749
18Vertebral compression fractures (HP:0002953)2.72122231
19Buphthalmos (HP:0000557)2.63342510
20Hemorrhage of the eye (HP:0011885)2.62103023
21Cerebral aneurysm (HP:0004944)2.60001713
22Deep venous thrombosis (HP:0002625)2.54993113
23Broad palm (HP:0001169)2.54747638
24Coronal craniosynostosis (HP:0004440)2.53004415
25Turricephaly (HP:0000262)2.52086625
26Renovascular hypertension (HP:0100817)2.51559617
27Fragile skin (HP:0001030)2.49304657
28Hyperacusis (HP:0010780)2.48079659
29Abnormal ossification of hand bones (HP:0005921)2.47408359
30Small epiphyses (HP:0010585)2.47309831
31Deviation of the hallux (HP:0010051)2.46492919
32Abnormal tarsal ossification (HP:0008369)2.44622937
33Hypoglycemic coma (HP:0001325)2.44398449
34Enlarged penis (HP:0000040)2.44137328
35Hallux valgus (HP:0001822)2.43836764
36Acanthocytosis (HP:0001927)2.40792607
37Ketoacidosis (HP:0001993)2.36048369
38Mitral valve prolapse (HP:0001634)2.34926084
39Thin bony cortex (HP:0002753)2.33105949
40Exostoses (HP:0100777)2.31357493
41Abnormality of the Achilles tendon (HP:0005109)2.28324266
42Elfin facies (HP:0004428)2.26238774
43Diaphragmatic weakness (HP:0009113)2.23223058
44Congenital glaucoma (HP:0001087)2.22142434
45Cholelithiasis (HP:0001081)2.21437267
46Neonatal short-limb short stature (HP:0008921)2.20678452
47Growth hormone excess (HP:0000845)2.19727236
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.19381584
49Rectal prolapse (HP:0002035)2.18797836
50Prolonged partial thromboplastin time (HP:0003645)2.18477812
51Overriding aorta (HP:0002623)2.14796829
52Subacute progressive viral hepatitis (HP:0006572)2.14755295
53Menorrhagia (HP:0000132)2.13626877
54Abnormal hand bone ossification (HP:0010660)2.12188439
55Hypercholesterolemia (HP:0003124)2.11767722
56Right ventricular cardiomyopathy (HP:0011663)2.11651829
57Cholecystitis (HP:0001082)2.11113060
58Abnormal gallbladder physiology (HP:0012438)2.11113060
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.10004751
60Broad face (HP:0000283)2.09324939
61Soft skin (HP:0000977)2.07738549
62Abnormality of reticulocytes (HP:0004312)2.07708953
63Abnormality of endocrine pancreas physiology (HP:0012093)2.07119593
64Abnormality of the pancreatic islet cells (HP:0006476)2.07119593
65Back pain (HP:0003418)2.06788647
66Joint hemorrhage (HP:0005261)2.05860206
67Abnormality of complement system (HP:0005339)2.04952765
68Abnormality of the common coagulation pathway (HP:0010990)2.04239577
69Achilles tendon contracture (HP:0001771)2.04210262
70Complement deficiency (HP:0004431)2.01823216
71Aortic dissection (HP:0002647)2.00686470
72Type 1 muscle fiber predominance (HP:0003803)1.99952740
73Abnormality of the acetabulum (HP:0003170)1.99908498
7411 pairs of ribs (HP:0000878)1.99324341
75Abnormality of the distal phalanx of the thumb (HP:0009617)1.98488990
76Macroorchidism (HP:0000053)1.98086224
77Blue sclerae (HP:0000592)1.97977956
78Hepatoblastoma (HP:0002884)1.97910479
79Insomnia (HP:0100785)1.97809785
80Ketosis (HP:0001946)1.97115971
81Distal lower limb amyotrophy (HP:0008944)1.95618155
82Bowel diverticulosis (HP:0005222)1.94184791
83Late onset (HP:0003584)1.93412714
84Aneurysm (HP:0002617)1.93166232
85Spastic diplegia (HP:0001264)1.91444595
86Hyperparathyroidism (HP:0000843)1.91009225
87Down-sloping shoulders (HP:0200021)1.90934937
88Germ cell neoplasia (HP:0100728)1.90653556
89Mildly elevated creatine phosphokinase (HP:0008180)1.89541209
90Xanthomatosis (HP:0000991)1.88367073
91Hypoglycemic seizures (HP:0002173)1.87890086
92Milia (HP:0001056)1.87778450
93Abnormality of the aortic arch (HP:0012303)1.86695991
94Abnormal gallbladder morphology (HP:0012437)1.86095866
95Neonatal death (HP:0003811)1.86083381
96Ankyloglossia (HP:0010296)1.85707387
97Cupped ribs (HP:0000887)1.83823759
98Hyperextensible skin (HP:0000974)1.83143455
99Distal lower limb muscle weakness (HP:0009053)1.82546043
100Cerebral inclusion bodies (HP:0100314)1.81439910
101Abnormal foot bone ossification (HP:0010675)1.79382320
102Cervical subluxation (HP:0003308)1.78547040
103Long toe (HP:0010511)1.78175894
104Polycythemia (HP:0001901)1.78058861
105Flat cornea (HP:0007720)1.77444348
106Abnormality of dentin (HP:0010299)1.77285535
107Abnormality of the nasal septum (HP:0000419)1.76196056
108Limited elbow extension (HP:0001377)1.75426587
109Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75106975
110Heterotopia (HP:0002282)1.74385421
111Overgrowth (HP:0001548)1.74379082
112Dilatation of the ascending aorta (HP:0005111)1.74279048
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74062624
114Absent epiphyses (HP:0010577)1.74062624
115Coxa vara (HP:0002812)1.74058873
116Wide anterior fontanel (HP:0000260)1.73555484
117Ulnar bowing (HP:0003031)1.73413269
118Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72462728
119Biconcave vertebral bodies (HP:0004586)1.72457348
120Abnormality of the calcaneus (HP:0008364)1.71496532
121Visceral angiomatosis (HP:0100761)1.70948141
122Arterial tortuosity (HP:0005116)1.69893558
123Hyperinsulinemic hypoglycemia (HP:0000825)1.68911064
124Asymmetry of the thorax (HP:0001555)1.68824100
125Peritonitis (HP:0002586)1.68353641
126Hypercortisolism (HP:0001578)1.68330661
127Intrahepatic cholestasis (HP:0001406)1.68074236
128Disproportionate tall stature (HP:0001519)1.67907468
129Gout (HP:0001997)1.67864052
130Abnormality of the thoracic spine (HP:0100711)1.67351818
131Missing ribs (HP:0000921)1.67286189
132Myopathic facies (HP:0002058)1.66961353
133Vertebral hypoplasia (HP:0008417)1.66834594
134Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.66834594
135Natal tooth (HP:0000695)1.66817814
136Pterygium (HP:0001059)1.66404346
137Epiphyseal dysplasia (HP:0002656)1.65330467
138Neurofibrillary tangles (HP:0002185)1.64621478
139Neoplasm of the heart (HP:0100544)1.64060956
140Spinal rigidity (HP:0003306)1.64003740
141Increased nuchal translucency (HP:0010880)1.63892255
142Scapular winging (HP:0003691)1.63347461
143Bronchomalacia (HP:0002780)1.63167136
144Wormian bones (HP:0002645)1.63086868
145Aortic aneurysm (HP:0004942)1.62624916
146Hypoplastic labia majora (HP:0000059)1.60430141
147Increased connective tissue (HP:0009025)1.59718363
148Abnormality of the distal phalanges of the toes (HP:0010182)1.58691252
149Hyperglycemia (HP:0003074)1.58570415
150Insidious onset (HP:0003587)1.58073178
151Termporal pattern (HP:0011008)1.58073178
152Rhizomelia (HP:0008905)1.57990610
153Vertebral arch anomaly (HP:0008438)1.57832139
154Pancreatic islet-cell hyperplasia (HP:0004510)1.57811024
155Abnormality of the gastric mucosa (HP:0004295)1.57209052
156Obstructive sleep apnea (HP:0002870)1.56736093
157Hemangiomatosis (HP:0007461)1.56281026
158Abnormality of the gallbladder (HP:0005264)1.56178518
159Deviation of the thumb (HP:0009603)1.55071384
160Pseudobulbar signs (HP:0002200)1.54733099
161Sprengel anomaly (HP:0000912)1.54225104
162Septate vagina (HP:0001153)1.53881134
163Advanced eruption of teeth (HP:0006288)1.53794773
164Exercise-induced myalgia (HP:0003738)1.53211468
165Intestinal polyp (HP:0005266)1.52619108
166Upper limb amyotrophy (HP:0009129)1.52294934
167Distal upper limb amyotrophy (HP:0007149)1.52294934
168Flattened epiphyses (HP:0003071)1.51932814
169Woolly hair (HP:0002224)1.51084379
170Abnormal pancreas size (HP:0012094)1.51036839
171Limb-girdle muscle weakness (HP:0003325)1.50618227
172Follicular hyperkeratosis (HP:0007502)1.50370624
173Alacrima (HP:0000522)1.49233172
174Striae distensae (HP:0001065)1.49169882
175Microglossia (HP:0000171)1.49157098
176Partial duplication of thumb phalanx (HP:0009944)1.48071707
177Hepatocellular carcinoma (HP:0001402)1.47656601
178Short 5th finger (HP:0009237)1.47224051
179Premature skin wrinkling (HP:0100678)1.47195990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.30928860
2PKN24.13247071
3CDK123.00814698
4PRPF4B2.94199478
5LATS12.92961870
6EPHB22.84783494
7PTK62.72232729
8PASK2.69942940
9SIK12.67864793
10PDGFRA2.55026212
11DDR22.44016679
12ERN12.34731467
13MAP3K102.24228483
14RIPK12.22883188
15EIF2AK12.16366924
16EEF2K2.09893076
17SMG11.94715150
18TAOK21.84284797
19TTN1.81522434
20PAK41.77574239
21MET1.77151371
22DYRK1B1.75988147
23BCKDK1.71755258
24IRAK31.63504968
25PTK21.50947430
26MAP2K21.44874703
27FER1.44293909
28FGFR21.43862604
29MST1R1.43342145
30LRRK21.43109355
31WNK41.39859598
32SCYL21.37383308
33ERBB21.27405850
34FGFR31.22214984
35FGFR41.16818142
36MAPK151.15850255
37ICK1.15107532
38MAP3K21.11975432
39CDK61.11033805
40LMTK21.10521676
41ILK1.09406963
42FLT31.08327442
43MAP3K31.07918073
44FGFR11.04112255
45CDK71.03881120
46NEK21.03842148
47KSR11.03819111
48PAK21.03066769
49TAOK11.01479601
50STK31.01093855
51EPHA31.01034452
52MTOR0.98679371
53BMX0.98116522
54MAPKAPK30.97590048
55INSRR0.95739305
56MARK20.95150365
57NEK10.92824814
58RET0.92115742
59EPHB10.90572575
60NME20.90464333
61UHMK10.89259064
62KSR20.88110106
63TGFBR10.87991705
64PAK30.87937230
65HIPK20.87022735
66MAP2K30.86287017
67DMPK0.84187275
68PDGFRB0.82755088
69SIK20.79724831
70BRD40.78750284
71PRKD30.78320364
72CAMKK10.77970191
73PIK3CA0.76953859
74LIMK10.73977274
75FRK0.73794420
76TYRO30.72960189
77LATS20.71393192
78SGK30.69051633
79MAP2K10.67658351
80PDPK10.67627919
81RPS6KB20.66718879
82MAP3K60.66427442
83AKT30.65700956
84CDK90.62513428
85RPS6KL10.62177716
86RPS6KC10.62177716
87MAP3K80.60883083
88BRSK10.60865806
89CDK80.59672410
90ARAF0.57638216
91CAMK1D0.57485625
92CSNK1A1L0.56344771
93MAP3K110.56139306
94PRKD10.54859616
95TIE10.54694952
96MAP3K70.54606308
97PRKD20.53662092
98ROCK10.52541286
99DYRK30.51989280
100MAPK110.50257140
101CAMK1G0.50027920
102BCR0.48413813
103TESK10.48312809
104SGK4940.48308845
105SGK2230.48308845
106NTRK10.48201726
107AKT20.47400766
108IRAK20.45655795
109RPS6KA40.45268626
110STK380.45084614
111PIM20.44698935
112TGFBR20.43825658
113MATK0.43375626
114NEK90.42893378
115AURKB0.42795950
116GSK3A0.42614837
117SIK30.41510768
118EPHA20.40197828
119CDK40.39395015
120CDC42BPA0.37768596
121RPS6KA60.37222344
122KDR0.36648470
123STK390.36516922
124MELK0.35355879
125ERBB30.35201645
126PRKAA20.34880664
127ROCK20.33585394
128ERBB40.33567422
129WNK10.33515065
130MAPK100.32677458
131TESK20.32532442
132CDC70.32160902
133CDK20.31478375
134CSNK1G10.31376979
135RPS6KA10.31279351
136PRKAA10.30863442
137PBK0.30416356
138CSNK1G30.28507145
139PAK60.28359536
140MAP3K10.24595526
141SRC0.24572103
142RPS6KA20.24531522
143PRKCI0.24226786

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.40625938
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.29566039
3Nitrogen metabolism_Homo sapiens_hsa009102.37792579
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22001388
5Basal cell carcinoma_Homo sapiens_hsa052172.14860644
6Protein digestion and absorption_Homo sapiens_hsa049742.07087185
7Sulfur metabolism_Homo sapiens_hsa009202.01974411
8Fat digestion and absorption_Homo sapiens_hsa049751.97017832
9Fatty acid degradation_Homo sapiens_hsa000711.96550107
10Other glycan degradation_Homo sapiens_hsa005111.87583509
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87564684
12Hedgehog signaling pathway_Homo sapiens_hsa043401.75737804
13Tryptophan metabolism_Homo sapiens_hsa003801.75191288
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.68518796
15Fructose and mannose metabolism_Homo sapiens_hsa000511.67865055
16ECM-receptor interaction_Homo sapiens_hsa045121.67273768
17Butanoate metabolism_Homo sapiens_hsa006501.65154826
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.62022806
19Lysine degradation_Homo sapiens_hsa003101.61722563
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55991995
21Bladder cancer_Homo sapiens_hsa052191.55685344
22Selenocompound metabolism_Homo sapiens_hsa004501.51034984
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44865244
24Pentose phosphate pathway_Homo sapiens_hsa000301.44726377
25Hippo signaling pathway_Homo sapiens_hsa043901.42685600
26Fatty acid metabolism_Homo sapiens_hsa012121.41388289
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40145262
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38909284
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36934196
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34264082
31Fatty acid biosynthesis_Homo sapiens_hsa000611.34245036
32Prion diseases_Homo sapiens_hsa050201.33697833
33Propanoate metabolism_Homo sapiens_hsa006401.30022184
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29410942
35Focal adhesion_Homo sapiens_hsa045101.27216799
36Bile secretion_Homo sapiens_hsa049761.26462641
37Arginine biosynthesis_Homo sapiens_hsa002201.26347047
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26036960
39Proteoglycans in cancer_Homo sapiens_hsa052051.23495005
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23238552
41Notch signaling pathway_Homo sapiens_hsa043301.16716409
42Small cell lung cancer_Homo sapiens_hsa052221.16450028
43Galactose metabolism_Homo sapiens_hsa000521.14800637
44Acute myeloid leukemia_Homo sapiens_hsa052211.12112141
45Chronic myeloid leukemia_Homo sapiens_hsa052201.11003317
46Pancreatic secretion_Homo sapiens_hsa049721.10287680
47Histidine metabolism_Homo sapiens_hsa003401.07547114
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.06076855
49Tight junction_Homo sapiens_hsa045301.04871504
50PPAR signaling pathway_Homo sapiens_hsa033201.04095234
51Adherens junction_Homo sapiens_hsa045201.03866665
52ErbB signaling pathway_Homo sapiens_hsa040121.03368050
53Endometrial cancer_Homo sapiens_hsa052131.00152530
54Pyruvate metabolism_Homo sapiens_hsa006200.99245199
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96310603
56Insulin resistance_Homo sapiens_hsa049310.96285408
57VEGF signaling pathway_Homo sapiens_hsa043700.93958485
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.92459989
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.91944626
60Folate biosynthesis_Homo sapiens_hsa007900.90228702
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88524558
62Biosynthesis of amino acids_Homo sapiens_hsa012300.88367999
63Starch and sucrose metabolism_Homo sapiens_hsa005000.88286880
64Carbon metabolism_Homo sapiens_hsa012000.85590739
65MicroRNAs in cancer_Homo sapiens_hsa052060.84834410
66Choline metabolism in cancer_Homo sapiens_hsa052310.84341399
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82941073
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82902391
69Melanogenesis_Homo sapiens_hsa049160.82200074
70AMPK signaling pathway_Homo sapiens_hsa041520.80657700
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79861213
72Tyrosine metabolism_Homo sapiens_hsa003500.79824656
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79500486
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78258099
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77635284
76N-Glycan biosynthesis_Homo sapiens_hsa005100.77169965
77Amoebiasis_Homo sapiens_hsa051460.76578408
78HIF-1 signaling pathway_Homo sapiens_hsa040660.75793025
79Phenylalanine metabolism_Homo sapiens_hsa003600.75620214
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.73684428
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73495943
82Renin-angiotensin system_Homo sapiens_hsa046140.72449355
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72265218
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72229421
85Renal cell carcinoma_Homo sapiens_hsa052110.71921467
86Thyroid cancer_Homo sapiens_hsa052160.71513433
87Axon guidance_Homo sapiens_hsa043600.71500871
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69574727
89Inositol phosphate metabolism_Homo sapiens_hsa005620.68709363
90Wnt signaling pathway_Homo sapiens_hsa043100.66906266
91Chemical carcinogenesis_Homo sapiens_hsa052040.65830171
92Prostate cancer_Homo sapiens_hsa052150.65272229
93Arginine and proline metabolism_Homo sapiens_hsa003300.65254972
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64842518
95GnRH signaling pathway_Homo sapiens_hsa049120.64451159
96beta-Alanine metabolism_Homo sapiens_hsa004100.63813824
97Colorectal cancer_Homo sapiens_hsa052100.61136937
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.60433149
99Steroid biosynthesis_Homo sapiens_hsa001000.60192565
100Insulin signaling pathway_Homo sapiens_hsa049100.59449588
101Systemic lupus erythematosus_Homo sapiens_hsa053220.59422733
102Non-small cell lung cancer_Homo sapiens_hsa052230.58795077
103Glioma_Homo sapiens_hsa052140.57983390
104Pancreatic cancer_Homo sapiens_hsa052120.57825827
105Complement and coagulation cascades_Homo sapiens_hsa046100.57144919
106Peroxisome_Homo sapiens_hsa041460.57108784
107mTOR signaling pathway_Homo sapiens_hsa041500.57069712
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56009191
109Endocytosis_Homo sapiens_hsa041440.55750207
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55714581
111Thyroid hormone synthesis_Homo sapiens_hsa049180.54611115
112Glucagon signaling pathway_Homo sapiens_hsa049220.52987938
113Pathways in cancer_Homo sapiens_hsa052000.52862037
114Fatty acid elongation_Homo sapiens_hsa000620.52146359
115Prolactin signaling pathway_Homo sapiens_hsa049170.51880318
116Vitamin digestion and absorption_Homo sapiens_hsa049770.51547332
117TGF-beta signaling pathway_Homo sapiens_hsa043500.51547248
118Type II diabetes mellitus_Homo sapiens_hsa049300.51350683
119FoxO signaling pathway_Homo sapiens_hsa040680.51040230
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51021421
121mRNA surveillance pathway_Homo sapiens_hsa030150.49842377
122ABC transporters_Homo sapiens_hsa020100.49602683
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48990382
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48899151
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.48453121
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47984540
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47274554
128Estrogen signaling pathway_Homo sapiens_hsa049150.46311958
129Dilated cardiomyopathy_Homo sapiens_hsa054140.46094173
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.45411575
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45272626
132Hepatitis C_Homo sapiens_hsa051600.44656299

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