GZMK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative thymic T cell selection (GO:0045060)9.33945768
2regulation of isotype switching to IgG isotypes (GO:0048302)8.94740801
3negative regulation of cell killing (GO:0031342)8.19939473
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.19939473
5positive regulation of gamma-delta T cell activation (GO:0046645)7.62788413
6thymic T cell selection (GO:0045061)7.61065022
7T cell migration (GO:0072678)7.57852570
8interferon-gamma production (GO:0032609)7.37865130
9activated T cell proliferation (GO:0050798)7.18345268
10positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)7.10565564
11positive regulation of natural killer cell mediated immunity (GO:0002717)7.10565564
12positive regulation of immune response to tumor cell (GO:0002839)7.03383431
13regulation of immune response to tumor cell (GO:0002837)7.03383431
14regulation of response to tumor cell (GO:0002834)7.03383431
15positive regulation of response to tumor cell (GO:0002836)7.03383431
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.92745756
17regulation of natural killer cell mediated cytotoxicity (GO:0042269)6.66809539
18regulation of natural killer cell mediated immunity (GO:0002715)6.66809539
19T cell selection (GO:0045058)6.56130237
20sequestering of actin monomers (GO:0042989)6.40937586
21positive T cell selection (GO:0043368)6.39168308
22positive thymic T cell selection (GO:0045059)6.27047269
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.95844041
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.95289994
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.95289994
26regulation of gamma-delta T cell differentiation (GO:0045586)5.91910384
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.84751368
28cellular response to interleukin-15 (GO:0071350)5.72131002
29T cell costimulation (GO:0031295)5.57205339
30T cell receptor signaling pathway (GO:0050852)5.54443481
31cytidine deamination (GO:0009972)5.52847001
32cytidine metabolic process (GO:0046087)5.52847001
33cytidine catabolic process (GO:0006216)5.52847001
34regulation of B cell receptor signaling pathway (GO:0050855)5.51902046
35positive regulation of isotype switching (GO:0045830)5.45440017
36lymphocyte costimulation (GO:0031294)5.45163524
37response to interleukin-15 (GO:0070672)5.41040631
38actin nucleation (GO:0045010)5.38822208
39cytolysis (GO:0019835)5.33402551
40regulation of gamma-delta T cell activation (GO:0046643)5.24400292
41positive regulation of alpha-beta T cell proliferation (GO:0046641)5.23927780
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.09266824
43pyrimidine ribonucleoside catabolic process (GO:0046133)5.00519053
44regulation of alpha-beta T cell proliferation (GO:0046640)4.95870505
45leukocyte aggregation (GO:0070486)4.93839955
46positive regulation of B cell mediated immunity (GO:0002714)4.89907687
47positive regulation of immunoglobulin mediated immune response (GO:0002891)4.89907687
48heterotypic cell-cell adhesion (GO:0034113)4.85091833
49antigen processing and presentation of endogenous antigen (GO:0019883)4.82425142
50DNA deamination (GO:0045006)4.80742343
51positive regulation of DNA recombination (GO:0045911)4.79731902
52positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.71408809
53regulation of leukocyte mediated cytotoxicity (GO:0001910)4.65228928
54lymphocyte migration (GO:0072676)4.54108028
55antigen receptor-mediated signaling pathway (GO:0050851)4.46933726
56positive regulation of B cell differentiation (GO:0045579)4.46139726
57regulation of isotype switching (GO:0045191)4.45986915
58negative regulation of T cell mediated immunity (GO:0002710)4.35130799
59regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.33565771
60negative regulation of T cell apoptotic process (GO:0070233)4.32895361
61negative regulation of stress fiber assembly (GO:0051497)4.31453310
62regulation of interleukin-2 biosynthetic process (GO:0045076)4.25429414
63negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.23751358
64regulation of immunoglobulin mediated immune response (GO:0002889)4.20997957
65positive regulation of cell killing (GO:0031343)4.19021590
66regulation of T cell tolerance induction (GO:0002664)4.18875803
67cellular defense response (GO:0006968)4.17340915
68regulation of defense response to virus by virus (GO:0050690)4.14406974
69leukocyte cell-cell adhesion (GO:0007159)4.12782318
70regulation of regulatory T cell differentiation (GO:0045589)4.11158043
71negative regulation of T cell receptor signaling pathway (GO:0050860)4.10756884
72regulation of T cell receptor signaling pathway (GO:0050856)4.09947962
73positive regulation of T cell mediated cytotoxicity (GO:0001916)4.08926947
74regulation of cell killing (GO:0031341)4.08691128
75mast cell activation (GO:0045576)4.08479087
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.08432769
77regulation of T cell mediated cytotoxicity (GO:0001914)4.05306594
78regulation of B cell mediated immunity (GO:0002712)4.04401962
79positive regulation of calcium-mediated signaling (GO:0050850)4.04360523
80antigen processing and presentation via MHC class Ib (GO:0002475)4.00242880
81regulation of activation of Janus kinase activity (GO:0010533)3.93398151
82respiratory burst (GO:0045730)3.80860117
83positive regulation of interleukin-8 secretion (GO:2000484)3.78614951
84positive regulation of interleukin-2 production (GO:0032743)3.74515236
85Arp2/3 complex-mediated actin nucleation (GO:0034314)3.71409526
86positive regulation of lamellipodium assembly (GO:0010592)3.60785015
87positive regulation of lymphocyte mediated immunity (GO:0002708)3.52733127
88regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.52585477
89positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.50594728
90regulation of lymphocyte mediated immunity (GO:0002706)3.46854473
91leukocyte tethering or rolling (GO:0050901)3.46668053
92T cell differentiation (GO:0030217)3.46121567
93positive regulation of interleukin-4 production (GO:0032753)3.41698954
94T cell activation (GO:0042110)3.40543689
95negative regulation of viral genome replication (GO:0045071)3.40234300
96natural killer cell activation (GO:0030101)3.36131756
97negative regulation of lymphocyte mediated immunity (GO:0002707)3.35521874
98T cell proliferation (GO:0042098)3.34753948
99positive regulation of immunoglobulin production (GO:0002639)3.32682920
100negative regulation of phagocytosis (GO:0050765)3.32603864
101cellular response to type I interferon (GO:0071357)3.28748705
102type I interferon signaling pathway (GO:0060337)3.28748705
103negative regulation of type 2 immune response (GO:0002829)3.27934868
104regulation of T cell chemotaxis (GO:0010819)3.26400369
105positive regulation of T cell chemotaxis (GO:0010820)3.26400369
106immune response-activating cell surface receptor signaling pathway (GO:0002429)3.25153813
107response to type I interferon (GO:0034340)3.24815013
108positive regulation of viral genome replication (GO:0045070)3.23943884
109positive regulation of tolerance induction (GO:0002645)3.23681519
110positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.21559856
111negative regulation of execution phase of apoptosis (GO:1900118)3.21134750
112negative regulation of actin filament bundle assembly (GO:0032232)3.21132293
113lymphocyte chemotaxis (GO:0048247)3.19332192
114immunoglobulin mediated immune response (GO:0016064)3.17629457
115NIK/NF-kappaB signaling (GO:0038061)3.17436444
116T cell mediated immunity (GO:0002456)3.14944337
117regulation of T cell apoptotic process (GO:0070232)3.14297681
118positive regulation of T cell mediated immunity (GO:0002711)3.07563582
119regulation of response to interferon-gamma (GO:0060330)3.07005732
120response to interferon-beta (GO:0035456)3.06277013
121regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.05953702
122mast cell activation involved in immune response (GO:0002279)3.05950438
123mast cell degranulation (GO:0043303)3.05950438
124B cell receptor signaling pathway (GO:0050853)3.05671702
125dendritic cell chemotaxis (GO:0002407)3.01748898
126positive regulation of T cell activation (GO:0050870)2.99982413
127regulation of B cell differentiation (GO:0045577)2.99939770
128negative regulation of oxidoreductase activity (GO:0051354)2.99552019
129positive regulation of leukocyte mediated immunity (GO:0002705)2.96871412
130regulation of immunoglobulin production (GO:0002637)2.89909059
131signal complex assembly (GO:0007172)2.87211649
132positive regulation of T cell proliferation (GO:0042102)2.86440987
133positive regulation of lamellipodium organization (GO:1902745)2.84245680
134regulation of tolerance induction (GO:0002643)2.83789030
135alpha-beta T cell activation (GO:0046631)2.83430805
136positive regulation of uterine smooth muscle contraction (GO:0070474)2.81751197
137negative T cell selection (GO:0043383)10.0186624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.35519912
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.66788935
3E2F7_22180533_ChIP-Seq_HELA_Human5.03711419
4STAT4_19710469_ChIP-ChIP_TH1__Mouse4.23732189
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.12893573
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.98181505
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.85171577
8RUNX_20019798_ChIP-Seq_JUKART_Human3.75538571
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.65271792
10MYB_26560356_Chip-Seq_TH2_Human3.60719566
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.59014049
12IRF8_22096565_ChIP-ChIP_GC-B_Human3.51395730
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21996159
14MAF_26560356_Chip-Seq_TH1_Human2.98469781
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.81908674
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.79502307
17* MYB_26560356_Chip-Seq_TH1_Human2.70727533
18* UTX_26944678_Chip-Seq_JUKART_Human2.70579470
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63661785
20MYC_22102868_ChIP-Seq_BL_Human2.51760244
21MAF_26560356_Chip-Seq_TH2_Human2.27341528
22GATA3_27048872_Chip-Seq_THYMUS_Human2.21076003
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20598407
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19150363
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13350180
26SPI1_23547873_ChIP-Seq_NB4_Human2.12166527
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.04037751
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.00223348
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.96693565
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95451200
31RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.86672504
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85163522
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81968373
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.77050030
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76144241
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74756535
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.73658362
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72467780
39VDR_21846776_ChIP-Seq_THP-1_Human1.57162785
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56445663
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53146422
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50751320
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47871374
44GATA3_26560356_Chip-Seq_TH2_Human1.47532235
45IRF1_19129219_ChIP-ChIP_H3396_Human1.47459966
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46400788
47VDR_22108803_ChIP-Seq_LS180_Human1.45101231
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44509334
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43083019
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42856437
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42552968
52SPI1_23127762_ChIP-Seq_K562_Human1.39398926
53BCL6_27268052_Chip-Seq_Bcells_Human1.38236862
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35309611
55VDR_23849224_ChIP-Seq_CD4+_Human1.34755433
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34516999
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33760139
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32945077
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29607043
60FOXP3_21729870_ChIP-Seq_TREG_Human1.26231800
61TCF7_22412390_ChIP-Seq_EML_Mouse1.26212137
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25885048
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21354033
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19944070
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17837757
66ELK1_19687146_ChIP-ChIP_HELA_Human1.17313039
67* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16499773
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.16222504
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14247473
70HTT_18923047_ChIP-ChIP_STHdh_Human1.12891206
71KDM2B_26808549_Chip-Seq_DND41_Human1.11087984
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10187082
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09883925
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09624260
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09560569
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08346052
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07973259
78CIITA_25753668_ChIP-Seq_RAJI_Human1.07000969
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03377244
80PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01903797
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01830427
82BCOR_27268052_Chip-Seq_Bcells_Human1.01681125
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01624274
84SCL_19346495_ChIP-Seq_HPC-7_Human1.00011097
85VDR_24763502_ChIP-Seq_THP-1_Human0.99943061
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98389212
87P300_27268052_Chip-Seq_Bcells_Human0.98222044
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97627746
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97271542
90* NANOG_20526341_ChIP-Seq_ESCs_Human0.95035939
91SA1_27219007_Chip-Seq_Bcells_Human0.92678677
92* FLI1_21867929_ChIP-Seq_CD8_Mouse0.91562594
93RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91506519
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.91214130
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90499417
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89735127
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89224803
98NCOR_22424771_ChIP-Seq_293T_Human0.89211200
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.88760791
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88423214
101RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87986733
102GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85931519
103FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85350356
104PU_27001747_Chip-Seq_BMDM_Mouse0.83945022
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83503952
106EST1_17652178_ChIP-ChIP_JURKAT_Human0.82802584
107E2F1_20622854_ChIP-Seq_HELA_Human0.82372977
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.81892047
109AR_20517297_ChIP-Seq_VCAP_Human0.81108698
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80469356
111KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.78839179
112CTCF_20526341_ChIP-Seq_ESCs_Human0.78633386
113* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.78513352
114BCAT_22108803_ChIP-Seq_LS180_Human0.77724319
115SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76846847
116TAF2_19829295_ChIP-Seq_ESCs_Human0.76498185
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76202347
118GATA6_21074721_ChIP-Seq_CACO-2_Human0.75858118
119ERG_20517297_ChIP-Seq_VCAP_Human0.75356362
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.74897976
121EZH2_22144423_ChIP-Seq_EOC_Human0.74451940
122EGR1_19032775_ChIP-ChIP_M12_Human0.74374795
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74257289
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73636547
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73331684
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.73184322
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70930779
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.70837696
129BP1_19119308_ChIP-ChIP_Hs578T_Human0.70447200
130* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.69305137
131GATA3_26560356_Chip-Seq_TH1_Human0.69262599
132STAT1_20625510_ChIP-Seq_HELA_Human0.68780482
133GATA3_21878914_ChIP-Seq_MCF-7_Human0.68755693
134NFE2_27457419_Chip-Seq_LIVER_Mouse0.68662741
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.67208534
136KDM2B_26808549_Chip-Seq_SUP-B15_Human0.66822347
137SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.66451586
138CTCF_26484167_Chip-Seq_Bcells_Mouse0.66147113
139CREB1_15753290_ChIP-ChIP_HEK293T_Human0.66079516
140LXR_22292898_ChIP-Seq_THP-1_Human0.65604298
141SPI1_20517297_ChIP-Seq_HL60_Human0.64355309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.53103240
2MP0003763_abnormal_thymus_physiology6.43562481
3MP0006082_CNS_inflammation4.05097117
4MP0009333_abnormal_splenocyte_physiolog3.66484432
5MP0000858_altered_metastatic_potential3.32551773
6MP0002420_abnormal_adaptive_immunity3.28598036
7MP0001819_abnormal_immune_cell3.22212949
8MP0001800_abnormal_humoral_immune3.16825274
9MP0000685_abnormal_immune_system3.12119317
10MP0002398_abnormal_bone_marrow3.11290407
11MP0005000_abnormal_immune_tolerance2.98277036
12MP0005025_abnormal_response_to2.89340886
13MP0002723_abnormal_immune_serum2.87031778
14MP0001790_abnormal_immune_system2.85920365
15MP0005387_immune_system_phenotype2.85920365
16MP0003448_altered_tumor_morphology2.83160491
17MP0009785_altered_susceptibility_to2.73912839
18MP0000703_abnormal_thymus_morphology2.68878687
19MP0000716_abnormal_immune_system2.65114515
20MP0002452_abnormal_antigen_presenting2.54140639
21MP0002405_respiratory_system_inflammati2.51432616
22MP0002166_altered_tumor_susceptibility2.50324254
23MP0002722_abnormal_immune_system2.39691945
24MP0001835_abnormal_antigen_presentation2.29489418
25MP0000689_abnormal_spleen_morphology2.25413792
26MP0002006_tumorigenesis2.23024957
27MP0002429_abnormal_blood_cell2.15227460
28MP0004947_skin_inflammation1.95004128
29MP0003724_increased_susceptibility_to1.93506611
30MP0005464_abnormal_platelet_physiology1.92167457
31MP0002148_abnormal_hypersensitivity_rea1.87996794
32MP0003436_decreased_susceptibility_to1.86639982
33MP0002933_joint_inflammation1.84738937
34MP0002419_abnormal_innate_immunity1.83556567
35MP0003646_muscle_fatigue1.75802774
36MP0003045_fibrosis1.74866414
37MP0001845_abnormal_inflammatory_respons1.69605140
38MP0002132_abnormal_respiratory_system1.67190623
39MP0005645_abnormal_hypothalamus_physiol1.66959810
40MP0010155_abnormal_intestine_physiology1.60522191
41MP0003866_abnormal_defecation1.57600762
42MP0002277_abnormal_respiratory_mucosa1.48164542
43MP0001986_abnormal_taste_sensitivity1.38283624
44MP0002019_abnormal_tumor_incidence1.33489236
45MP0002396_abnormal_hematopoietic_system1.32086762
46MP0001873_stomach_inflammation1.31155899
47MP0008469_abnormal_protein_level1.20819482
48MP0003878_abnormal_ear_physiology1.20205703
49MP0005377_hearing/vestibular/ear_phenot1.20205703
50MP0002822_catalepsy1.15528706
51MP0008872_abnormal_physiological_respon1.12345285
52MP0003806_abnormal_nucleotide_metabolis1.11631284
53MP0008057_abnormal_DNA_replication1.10934467
54MP0002009_preneoplasia1.06381944
55MP0001853_heart_inflammation1.03261261
56MP0002102_abnormal_ear_morphology1.00866757
57MP0009764_decreased_sensitivity_to0.98467846
58MP0003011_delayed_dark_adaptation0.98089403
59MP0001851_eye_inflammation0.97886973
60MP0004957_abnormal_blastocyst_morpholog0.97034228
61MP0009763_increased_sensitivity_to0.96623917
62MP0003787_abnormal_imprinting0.96289866
63MP0002998_abnormal_bone_remodeling0.96100521
64MP0006054_spinal_hemorrhage0.95686561
65MP0001533_abnormal_skeleton_physiology0.93517919
66MP0008961_abnormal_basal_metabolism0.91400868
67MP0005166_decreased_susceptibility_to0.89460049
68MP0008877_abnormal_DNA_methylation0.87568888
69MP0001542_abnormal_bone_strength0.86552778
70MP0005451_abnormal_body_composition0.86412905
71MP0001919_abnormal_reproductive_system0.83174302
72MP0003950_abnormal_plasma_membrane0.82289701
73MP0000604_amyloidosis0.80816126
74MP0005410_abnormal_fertilization0.79474389
75MP0010352_gastrointestinal_tract_polyps0.78126562
76MP0004808_abnormal_hematopoietic_stem0.77593674
77MP0003075_altered_response_to0.75772493
78MP0001765_abnormal_ion_homeostasis0.74316657
79MP0001529_abnormal_vocalization0.74096492
80MP0000920_abnormal_myelination0.73753316
81MP0005584_abnormal_enzyme/coenzyme_acti0.70098117
82MP0004883_abnormal_blood_vessel0.69481429
83MP0003300_gastrointestinal_ulcer0.69274161
84MP0005623_abnormal_meninges_morphology0.68507826
85MP0002693_abnormal_pancreas_physiology0.66394543
86MP0003690_abnormal_glial_cell0.66093126
87MP0000490_abnormal_crypts_of0.65954712
88MP0002138_abnormal_hepatobiliary_system0.65553824
89MP0003279_aneurysm0.64739309
90MP0005058_abnormal_lysosome_morphology0.63890741
91MP0002136_abnormal_kidney_physiology0.63707308
92MP0003137_abnormal_impulse_conducting0.63622082
93MP0008873_increased_physiological_sensi0.61632104
94MP0003172_abnormal_lysosome_physiology0.61195064
95MP0001968_abnormal_touch/_nociception0.60501769
96MP0002163_abnormal_gland_morphology0.60299660
97MP0004510_myositis0.59711019
98MP0003656_abnormal_erythrocyte_physiolo0.58876049
99MP0009643_abnormal_urine_homeostasis0.57864429
100MP0005390_skeleton_phenotype0.56354334
101MP0008875_abnormal_xenobiotic_pharmacok0.56036866
102MP0003183_abnormal_peptide_metabolism0.55198706
103MP0001243_abnormal_dermal_layer0.54204836
104MP0005551_abnormal_eye_electrophysiolog0.54116481
105MP0001191_abnormal_skin_condition0.53952898
106MP0004130_abnormal_muscle_cell0.53641688
107MP0005636_abnormal_mineral_homeostasis0.53285407
108MP0004145_abnormal_muscle_electrophysio0.52615584
109MP0003786_premature_aging0.52149260
110MP0001501_abnormal_sleep_pattern0.50702461
111MP0009642_abnormal_blood_homeostasis0.50059999
112MP0008995_early_reproductive_senescence0.49839378
113MP0001663_abnormal_digestive_system0.49369672
114MP0003693_abnormal_embryo_hatching0.49038916
115MP0004147_increased_porphyrin_level0.48673324
116MP0002083_premature_death0.48606034
117MP0003252_abnormal_bile_duct0.47942733
118MP0005164_abnormal_response_to0.47597549
119MP0003077_abnormal_cell_cycle0.46833648
120MP0003880_abnormal_central_pattern0.46661877
121MP0005379_endocrine/exocrine_gland_phen0.45402619
122MP0010234_abnormal_vibrissa_follicle0.44506985
123MP0003795_abnormal_bone_structure0.44247688
124MP0000609_abnormal_liver_physiology0.43537815
125MP0008770_decreased_survivor_rate0.42901081
126MP0004859_abnormal_synaptic_plasticity0.42741000
127MP0005023_abnormal_wound_healing0.41940396
128MP0003566_abnormal_cell_adhesion0.41245405
129MP0004381_abnormal_hair_follicle0.40039477
130MP0002127_abnormal_cardiovascular_syste0.39641028
131MP0003943_abnormal_hepatobiliary_system0.39530746
132MP0003111_abnormal_nucleus_morphology0.39118963
133MP0000613_abnormal_salivary_gland0.37202395
134MP0005360_urolithiasis0.34938906
135MP0010094_abnormal_chromosome_stability0.33758257
136MP0000477_abnormal_intestine_morphology0.32847991
137MP0000465_gastrointestinal_hemorrhage0.31367004
138MP0009745_abnormal_behavioral_response0.31331745
139MP0005310_abnormal_salivary_gland0.31045849
140MP0008874_decreased_physiological_sensi0.30051151
141MP0001905_abnormal_dopamine_level0.29552074
142MP0005075_abnormal_melanosome_morpholog0.29347663

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.11091722
2Abnormality of T cell number (HP:0011839)8.65583131
3Aplastic anemia (HP:0001915)7.12068434
4Nasal polyposis (HP:0100582)5.49129554
5Combined immunodeficiency (HP:0005387)5.30531199
6Abnormality of T cells (HP:0002843)5.22105640
7Severe combined immunodeficiency (HP:0004430)4.82160192
8Elevated erythrocyte sedimentation rate (HP:0003565)4.81181221
9Hypoproteinemia (HP:0003075)4.48918676
10Gastrointestinal infarctions (HP:0005244)4.47318518
11Abnormality of the nasal mucosa (HP:0000433)4.38104831
12Abnormality of oral frenula (HP:0000190)4.35988337
13Joint swelling (HP:0001386)4.24399902
14Chronic otitis media (HP:0000389)4.10051076
15Encephalitis (HP:0002383)4.07192952
16Increased IgM level (HP:0003496)4.05636893
17Recurrent bronchitis (HP:0002837)4.02379937
18IgG deficiency (HP:0004315)3.87023215
19IgM deficiency (HP:0002850)3.76333187
20Pustule (HP:0200039)3.76261059
21Myositis (HP:0100614)3.69161325
22Diplopia (HP:0000651)3.45565933
23Abnormality of binocular vision (HP:0011514)3.45565933
24Recurrent abscess formation (HP:0002722)3.45382806
25Absent rod-and cone-mediated responses on ERG (HP:0007688)3.42110344
26Recurrent viral infections (HP:0004429)3.38335162
27Abnormality of eosinophils (HP:0001879)3.36242985
28Renal cortical cysts (HP:0000803)3.31266776
29Abnormality of the prostate (HP:0008775)3.30815606
30Meningitis (HP:0001287)3.26308633
31Congenital stationary night blindness (HP:0007642)3.23726024
32Eczematoid dermatitis (HP:0000976)3.22234784
33Leukocytosis (HP:0001974)3.17550952
34Abnormality of B cell number (HP:0010975)3.16048149
35Trigonocephaly (HP:0000243)3.15963452
36Lymphopenia (HP:0001888)3.12993242
37Keratoconjunctivitis sicca (HP:0001097)3.07641582
38Obstructive lung disease (HP:0006536)3.07292732
39Chronic obstructive pulmonary disease (HP:0006510)3.07292732
403-Methylglutaconic aciduria (HP:0003535)3.06132990
41Pancytopenia (HP:0001876)3.04733333
42Abnormality of cells of the lymphoid lineage (HP:0012140)2.95592178
43Autoimmune hemolytic anemia (HP:0001890)2.94515552
44Ureteral stenosis (HP:0000071)2.91800266
45Recurrent fungal infections (HP:0002841)2.87500426
46Autoimmune thrombocytopenia (HP:0001973)2.86138773
47Spontaneous hematomas (HP:0007420)2.84700716
48Hemoptysis (HP:0002105)2.82078246
49Amaurosis fugax (HP:0100576)2.76154181
50Pulmonary embolism (HP:0002204)2.76011512
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.74429542
52Eosinophilia (HP:0001880)2.74361734
53Keratoconjunctivitis (HP:0001096)2.72261922
54Abnormal rod and cone electroretinograms (HP:0008323)2.69875975
55Panhypogammaglobulinemia (HP:0003139)2.66768932
56Amyotrophic lateral sclerosis (HP:0007354)2.65979487
57Ureteral obstruction (HP:0006000)2.65747012
58Stomach cancer (HP:0012126)2.61796498
59Increased intramyocellular lipid droplets (HP:0012240)2.59982747
60Basal cell carcinoma (HP:0002671)2.56157255
61Mediastinal lymphadenopathy (HP:0100721)2.55735839
62Recurrent otitis media (HP:0000403)2.50644951
63Stomatitis (HP:0010280)2.49182063
64Nonimmune hydrops fetalis (HP:0001790)2.48999671
65Epistaxis (HP:0000421)2.46844541
66Thyroiditis (HP:0100646)2.45310443
67Pulmonary infiltrates (HP:0002113)2.44731855
68Vasculitis (HP:0002633)2.43339866
69Hypergammaglobulinemia (HP:0010702)2.42295522
70Retrobulbar optic neuritis (HP:0100654)2.41518294
71Optic neuritis (HP:0100653)2.41518294
72Recurrent skin infections (HP:0001581)2.40441232
73Recurrent sinusitis (HP:0011108)2.39236620
74Abnormal foot bone ossification (HP:0010675)2.37869657
75Abnormal platelet volume (HP:0011876)2.32613092
76Dislocated radial head (HP:0003083)2.29580182
77Gangrene (HP:0100758)2.28081743
78Arterial thrombosis (HP:0004420)2.27758712
79Increased muscle lipid content (HP:0009058)2.27352828
80Lymphoma (HP:0002665)2.27318357
81Gastrointestinal inflammation (HP:0004386)2.27279913
82Pigmentary retinal degeneration (HP:0001146)2.26899445
83Papilloma (HP:0012740)2.26126941
84Verrucae (HP:0200043)2.26126941
85Chronic mucocutaneous candidiasis (HP:0002728)2.25037194
86Recurrent cutaneous fungal infections (HP:0011370)2.25037194
87Recurrent gram-negative bacterial infections (HP:0005420)2.23395319
88Bilateral sensorineural hearing impairment (HP:0008619)2.23213629
89Oral leukoplakia (HP:0002745)2.21276517
90Aortic dissection (HP:0002647)2.21138745
91Abnormality of the alveolar ridges (HP:0006477)2.20644002
92Granulocytopenia (HP:0001913)2.19811899
93Abnormality of the fingertips (HP:0001211)2.19192144
94Bronchitis (HP:0012387)2.18702828
95B lymphocytopenia (HP:0010976)2.16978583
96Chronic sinusitis (HP:0011109)2.15946367
97Chest pain (HP:0100749)2.15574545
98Prostate neoplasm (HP:0100787)2.14699952
99Papilledema (HP:0001085)2.13270342
100Increased IgE level (HP:0003212)2.12732965
101Abnormality of the radial head (HP:0003995)2.12646830
102Anorexia (HP:0002039)2.11523242
103Mitochondrial inheritance (HP:0001427)2.10130674
104Acrocyanosis (HP:0001063)2.08898465
105Attenuation of retinal blood vessels (HP:0007843)2.06625565
106Recurrent bacterial skin infections (HP:0005406)2.05279266
107Abnormality of macrophages (HP:0004311)2.01819926
108Orchitis (HP:0100796)2.00952631
109Hypoalbuminemia (HP:0003073)1.99621954
110Abnormal albumin level (HP:0012116)1.99621954
111Premature graying of hair (HP:0002216)1.98872512
112Radial bowing (HP:0002986)1.98638739
113Vertebral arch anomaly (HP:0008438)1.97945366
114Increased hepatocellular lipid droplets (HP:0006565)1.97516843
115Cellular immunodeficiency (HP:0005374)1.96232160
116Inflammation of the large intestine (HP:0002037)1.95768495
117Severe visual impairment (HP:0001141)1.95280982
118Cerebral palsy (HP:0100021)1.94069794
119Hemiplegia (HP:0002301)1.92828456
120Abnormality of T cell physiology (HP:0011840)1.91791417
121Prolonged bleeding time (HP:0003010)1.91303682
122Chronic diarrhea (HP:0002028)1.91068520
123Increased mean platelet volume (HP:0011877)1.90605769
124Periorbital edema (HP:0100539)1.87849912
125Purpura (HP:0000979)1.87505828
126Acute hepatic failure (HP:0006554)1.84765746
127Growth hormone excess (HP:0000845)1.84668577
128Hypochromic anemia (HP:0001931)1.83004705
129Microcytic anemia (HP:0001935)1.80254492
130Bronchiectasis (HP:0002110)1.79153727
131Hypoplasia of the thymus (HP:0000778)1.78444804
132Acute necrotizing encephalopathy (HP:0006965)1.77362503
133Petechiae (HP:0000967)1.74024509
134Urticaria (HP:0001025)1.73840414
135Renal Fanconi syndrome (HP:0001994)1.73802332
136Lipid accumulation in hepatocytes (HP:0006561)1.73398023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.44832360
2MAP4K16.19252001
3ITK5.36219069
4SCYL23.20064674
5MST43.16184176
6TESK22.98439909
7ZAP702.96745273
8GRK62.70872099
9STK102.69048277
10JAK32.53481138
11CSK2.20486171
12MUSK2.15858015
13LCK2.10891007
14CLK12.09310206
15MAP3K121.88477360
16TNK21.81835575
17TYK21.75582658
18FES1.62859472
19JAK11.58309330
20MAP3K111.54024074
21PRKCQ1.49991322
22CAMKK11.45913713
23GRK71.44981220
24LRRK21.44601349
25SYK1.43084508
26TEC1.39898470
27CAMKK21.36535032
28KDR1.35864865
29BLK1.35529622
30FGFR41.32461437
31PRKCH1.32399498
32STK161.29477744
33VRK21.24775345
34ZAK1.23581028
35NME21.23507062
36RIPK41.23316011
37CDC71.20935997
38IKBKE1.20546189
39SIK31.14292377
40BTK1.13026711
41IRAK41.12548160
42SIK21.11024426
43VRK11.06072403
44NLK1.04443677
45TYRO31.03969997
46MAP3K140.97205494
47MELK0.95071048
48TESK10.92915513
49HCK0.91887360
50TTN0.88827137
51DMPK0.88747604
52ADRBK20.88507496
53TBK10.86376169
54PASK0.85242762
55GRK10.76835932
56TAOK20.73256290
57MAP3K100.72953142
58STK240.71619828
59ILK0.70576876
60ALK0.68501838
61TRPM70.68014410
62FGFR30.67694316
63PINK10.66865929
64LYN0.66436007
65PRKD30.61088321
66TSSK60.60883484
67FYN0.59630067
68ROCK10.59539713
69TRIB30.59381399
70IGF1R0.58769376
71MAP2K60.57389536
72ADRBK10.55637746
73PIK3CG0.54473472
74INSR0.53384423
75KIT0.51471203
76TLK10.50725164
77JAK20.50203436
78MAP3K30.49384908
79MARK30.47557681
80CSF1R0.46386093
81DAPK10.45680646
82TAOK10.45390018
83NUAK10.43927674
84MAP3K50.42768922
85EIF2AK10.40966447
86PRKCD0.40328426
87PIM10.40094361
88BUB10.39915772
89NEK20.39645604
90FRK0.36735957
91BCKDK0.36679804
92GRK50.35883993
93WNK40.34713527
94ERBB30.34327137
95CDK190.33069833
96CDK180.33040053
97MAP4K20.32509354
98TGFBR20.31520500
99PDK10.31394669
100PDGFRB0.31334214
101MAP3K130.29259173
102RPS6KC10.28730160
103RPS6KL10.28730160
104CDK40.28587720
105CDK150.28431493
106PRKG20.28127752
107OBSCN0.27777210
108RPS6KA50.27674594
109STK380.26586920
110RAF10.26519166
111CDK11A0.26467210
112RPS6KA60.25413850
113TAOK30.25175867
114MAPK110.25073755
115PRKCA0.24890059
116ROCK20.24410339
117EEF2K0.24394329
118EPHB10.24375228
119PRPF4B0.24339310
120PRKCB0.23252151
121INSRR0.23161120
122IKBKB0.23128437
123PAK10.22695209
124NEK90.22351282
125CSNK1G30.22014134
126BMPR20.21970895
127MYLK0.21511325
128LIMK10.21145062
129ERBB20.20852264
130FGR0.20763463
131MAPKAPK20.20257474
132RPS6KA40.19402526
133EGFR0.18987654
134BMX0.18971665
135AURKB0.16463325
136ABL10.16345006
137SRC0.16219649
138MAPK90.14807773
139NEK60.14390108
140PRKACA0.13331777
141MAPK150.12720713

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053328.40901219
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.96036135
3Primary immunodeficiency_Homo sapiens_hsa053404.65591210
4Antigen processing and presentation_Homo sapiens_hsa046123.91107132
5T cell receptor signaling pathway_Homo sapiens_hsa046603.49180107
6Allograft rejection_Homo sapiens_hsa053303.37652120
7Viral myocarditis_Homo sapiens_hsa054162.72984021
8Type I diabetes mellitus_Homo sapiens_hsa049402.54287041
9Autoimmune thyroid disease_Homo sapiens_hsa053202.44601908
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.41320918
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19376278
12Measles_Homo sapiens_hsa051622.12571689
13Oxidative phosphorylation_Homo sapiens_hsa001902.01045079
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.76632607
15Ribosome_Homo sapiens_hsa030101.48975830
16Hematopoietic cell lineage_Homo sapiens_hsa046401.39892204
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.39186165
18Phototransduction_Homo sapiens_hsa047441.38077389
19Leishmaniasis_Homo sapiens_hsa051401.31027803
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18732595
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15598776
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14904836
23Nitrogen metabolism_Homo sapiens_hsa009101.14106226
24DNA replication_Homo sapiens_hsa030301.13425896
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11156295
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.10293358
27Chemokine signaling pathway_Homo sapiens_hsa040621.08955348
28Staphylococcus aureus infection_Homo sapiens_hsa051501.03179872
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01781233
30Mismatch repair_Homo sapiens_hsa034301.01283211
31Shigellosis_Homo sapiens_hsa051311.00888346
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99230516
33B cell receptor signaling pathway_Homo sapiens_hsa046620.98707934
34Rheumatoid arthritis_Homo sapiens_hsa053230.97360144
35Osteoclast differentiation_Homo sapiens_hsa043800.94772272
36Proteasome_Homo sapiens_hsa030500.93162194
37Linoleic acid metabolism_Homo sapiens_hsa005910.89468017
38Cardiac muscle contraction_Homo sapiens_hsa042600.87177905
39Base excision repair_Homo sapiens_hsa034100.81696799
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79930426
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77448541
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77384902
43Platelet activation_Homo sapiens_hsa046110.76723439
44Legionellosis_Homo sapiens_hsa051340.76499851
45Huntingtons disease_Homo sapiens_hsa050160.73638001
46Asthma_Homo sapiens_hsa053100.72620026
47HTLV-I infection_Homo sapiens_hsa051660.71146401
48Apoptosis_Homo sapiens_hsa042100.70629108
49Herpes simplex infection_Homo sapiens_hsa051680.69398211
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69076840
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69015577
52VEGF signaling pathway_Homo sapiens_hsa043700.68430208
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.67265331
54Salmonella infection_Homo sapiens_hsa051320.63695738
55Systemic lupus erythematosus_Homo sapiens_hsa053220.63549528
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62027872
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61872897
58Hepatitis B_Homo sapiens_hsa051610.61830636
59Pancreatic cancer_Homo sapiens_hsa052120.60900726
60ABC transporters_Homo sapiens_hsa020100.60316561
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58601772
62Pertussis_Homo sapiens_hsa051330.58234411
63Malaria_Homo sapiens_hsa051440.57098424
64Influenza A_Homo sapiens_hsa051640.56269260
65RNA polymerase_Homo sapiens_hsa030200.55137248
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53345423
67Peroxisome_Homo sapiens_hsa041460.52398010
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.50563889
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50091534
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49375903
71Non-homologous end-joining_Homo sapiens_hsa034500.49133612
72Colorectal cancer_Homo sapiens_hsa052100.47379636
73Tuberculosis_Homo sapiens_hsa051520.45431341
74Toxoplasmosis_Homo sapiens_hsa051450.43415897
75African trypanosomiasis_Homo sapiens_hsa051430.41037291
76Taste transduction_Homo sapiens_hsa047420.40807153
77Retinol metabolism_Homo sapiens_hsa008300.39272967
78Rap1 signaling pathway_Homo sapiens_hsa040150.38447096
79Long-term potentiation_Homo sapiens_hsa047200.37167579
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.36421856
81Chemical carcinogenesis_Homo sapiens_hsa052040.35841895
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.35403815
83Epstein-Barr virus infection_Homo sapiens_hsa051690.34699799
84TNF signaling pathway_Homo sapiens_hsa046680.34142479
85Regulation of autophagy_Homo sapiens_hsa041400.33899459
86Non-small cell lung cancer_Homo sapiens_hsa052230.33677139
87Endocytosis_Homo sapiens_hsa041440.33138713
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29244967
89Hepatitis C_Homo sapiens_hsa051600.28585202
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28584222
91Phagosome_Homo sapiens_hsa041450.28523371
92MAPK signaling pathway_Homo sapiens_hsa040100.28496405
93Caffeine metabolism_Homo sapiens_hsa002320.27521680
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27439595
95Renin secretion_Homo sapiens_hsa049240.27388292
96p53 signaling pathway_Homo sapiens_hsa041150.27053699
97Parkinsons disease_Homo sapiens_hsa050120.26819621
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.25355909
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24411583
100Spliceosome_Homo sapiens_hsa030400.23019497
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22930983
102Ras signaling pathway_Homo sapiens_hsa040140.22193714
103RNA degradation_Homo sapiens_hsa030180.19838880
104Dilated cardiomyopathy_Homo sapiens_hsa054140.19121626
105Arachidonic acid metabolism_Homo sapiens_hsa005900.18876382
106Calcium signaling pathway_Homo sapiens_hsa040200.18411787
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.17690648
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.17428555
109Gastric acid secretion_Homo sapiens_hsa049710.17102330
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16810471
111Prion diseases_Homo sapiens_hsa050200.16779144
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16371732
113Viral carcinogenesis_Homo sapiens_hsa052030.15814284
114FoxO signaling pathway_Homo sapiens_hsa040680.15646538
115Nicotine addiction_Homo sapiens_hsa050330.14097925
116Purine metabolism_Homo sapiens_hsa002300.13978028
117Morphine addiction_Homo sapiens_hsa050320.13958285
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13433642
119Salivary secretion_Homo sapiens_hsa049700.12443711
120Renal cell carcinoma_Homo sapiens_hsa052110.12328089
121Oxytocin signaling pathway_Homo sapiens_hsa049210.11809167
122Focal adhesion_Homo sapiens_hsa045100.11507384
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.10401683
124Nucleotide excision repair_Homo sapiens_hsa034200.09992518
125Cell cycle_Homo sapiens_hsa041100.09885067
126Pyrimidine metabolism_Homo sapiens_hsa002400.08576636
127Protein export_Homo sapiens_hsa030600.08031343
128Acute myeloid leukemia_Homo sapiens_hsa052210.07882416
129cAMP signaling pathway_Homo sapiens_hsa040240.07535615
130Complement and coagulation cascades_Homo sapiens_hsa046100.07522780
131Amphetamine addiction_Homo sapiens_hsa050310.06296079
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.05744633
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.05712956
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04830679
135Alzheimers disease_Homo sapiens_hsa050100.04427682
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.03203469
137Oocyte meiosis_Homo sapiens_hsa041140.02849246
138Olfactory transduction_Homo sapiens_hsa047400.02693728
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02059664

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