GZMH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.58325230
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.79457671
3activated T cell proliferation (GO:0050798)6.50911647
4regulation of B cell receptor signaling pathway (GO:0050855)6.25513525
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.06993892
6antigen processing and presentation of endogenous antigen (GO:0019883)6.04833434
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.99721035
8negative regulation of cell killing (GO:0031342)5.99721035
9cytidine deamination (GO:0009972)5.85037011
10cytidine metabolic process (GO:0046087)5.85037011
11cytidine catabolic process (GO:0006216)5.85037011
12regulation of natural killer cell mediated immunity (GO:0002715)5.84886507
13regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.84886507
14positive regulation of natural killer cell mediated immunity (GO:0002717)5.64586870
15positive regulation of gamma-delta T cell activation (GO:0046645)5.41592173
16T cell migration (GO:0072678)5.36195291
17negative T cell selection (GO:0043383)5.32408887
18positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.19466587
19pyrimidine ribonucleoside catabolic process (GO:0046133)5.17063502
20positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.12228213
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.01875996
22positive T cell selection (GO:0043368)4.97710831
23DNA deamination (GO:0045006)4.86198080
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.85987073
25regulation of activation of Janus kinase activity (GO:0010533)4.85280452
26cellular response to interleukin-15 (GO:0071350)4.81227138
27regulation of leukocyte mediated cytotoxicity (GO:0001910)4.78178169
28leukocyte aggregation (GO:0070486)4.73519944
29positive regulation of T cell mediated cytotoxicity (GO:0001916)4.72531656
30Arp2/3 complex-mediated actin nucleation (GO:0034314)4.69252613
31regulation of T cell tolerance induction (GO:0002664)4.68543466
32antigen processing and presentation via MHC class Ib (GO:0002475)4.60455089
33positive regulation of cell killing (GO:0031343)4.57722669
34positive thymic T cell selection (GO:0045059)4.52021402
35negative thymic T cell selection (GO:0045060)4.46619186
36regulation of cell killing (GO:0031341)4.31752052
37regulation of T cell mediated cytotoxicity (GO:0001914)4.31540409
38thymic T cell selection (GO:0045061)4.27592858
39regulation of isotype switching to IgG isotypes (GO:0048302)4.25960103
40regulation of B cell differentiation (GO:0045577)4.24530743
41regulation of gamma-delta T cell differentiation (GO:0045586)4.22808107
42positive regulation of tolerance induction (GO:0002645)4.21913734
43response to interleukin-15 (GO:0070672)4.21288103
44T cell selection (GO:0045058)4.16300399
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.10135687
46negative regulation of phagocytosis (GO:0050765)4.10090143
47cellular defense response (GO:0006968)4.07995215
48actin nucleation (GO:0045010)4.02754036
49lymphocyte migration (GO:0072676)4.02668875
50regulation of tolerance induction (GO:0002643)3.99007682
51positive regulation of calcium-mediated signaling (GO:0050850)3.98977920
52regulation of regulatory T cell differentiation (GO:0045589)3.97983134
53regulation of gamma-delta T cell activation (GO:0046643)3.96584094
54interferon-gamma production (GO:0032609)3.77749381
55negative regulation of viral genome replication (GO:0045071)3.76848642
56positive regulation of B cell differentiation (GO:0045579)3.72543133
57regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.68828599
58* cytolysis (GO:0019835)3.68811956
59T cell receptor signaling pathway (GO:0050852)3.68653269
60mast cell activation (GO:0045576)3.68329670
61positive regulation of lymphocyte mediated immunity (GO:0002708)3.68299108
62respiratory burst (GO:0045730)3.67426466
63type I interferon signaling pathway (GO:0060337)3.63515051
64cellular response to type I interferon (GO:0071357)3.63515051
65response to type I interferon (GO:0034340)3.61277240
66negative regulation of leukocyte mediated immunity (GO:0002704)3.58247591
67regulation of alpha-beta T cell proliferation (GO:0046640)3.55700507
68lymphocyte chemotaxis (GO:0048247)3.50871570
69negative regulation of lymphocyte mediated immunity (GO:0002707)3.50240828
70positive regulation of T cell mediated immunity (GO:0002711)3.44799267
71antigen receptor-mediated signaling pathway (GO:0050851)3.39940374
72regulation of T cell receptor signaling pathway (GO:0050856)3.32605952
73positive regulation of leukocyte mediated immunity (GO:0002705)3.32572750
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.32469076
75regulation of interleukin-2 biosynthetic process (GO:0045076)3.32341689
76mast cell activation involved in immune response (GO:0002279)3.30444891
77mast cell degranulation (GO:0043303)3.30444891
78negative regulation of T cell apoptotic process (GO:0070233)3.27914762
79response to interferon-beta (GO:0035456)3.27831687
80T cell costimulation (GO:0031295)3.27216376
81positive regulation of T cell chemotaxis (GO:0010820)3.25402466
82regulation of T cell chemotaxis (GO:0010819)3.25402466
83positive regulation of alpha-beta T cell proliferation (GO:0046641)3.23351361
84lymphocyte costimulation (GO:0031294)3.23218523
85negative regulation of stress fiber assembly (GO:0051497)3.23116388
86immunoglobulin mediated immune response (GO:0016064)3.19249026
87regulation of lymphocyte mediated immunity (GO:0002706)3.18352794
88macrophage chemotaxis (GO:0048246)3.17422572
89leukocyte degranulation (GO:0043299)3.16629374
90regulation of lymphocyte chemotaxis (GO:1901623)3.16409104
91negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.13370458
92negative regulation of interleukin-12 production (GO:0032695)3.10205228
93natural killer cell activation (GO:0030101)3.06970078
94regulation of T cell mediated immunity (GO:0002709)3.06309502
95detection of bacterium (GO:0016045)3.05852033
96positive regulation of interleukin-4 production (GO:0032753)3.05308482
97myeloid cell activation involved in immune response (GO:0002275)3.04462865
98positive regulation of defense response to virus by host (GO:0002230)3.03317267
99macrophage activation involved in immune response (GO:0002281)3.01399296
100positive regulation of isotype switching (GO:0045830)2.96610869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.96480079
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.64341515
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.45393963
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.19226933
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.70600150
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.50942372
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.26897409
8RUNX_20019798_ChIP-Seq_JUKART_Human3.26777918
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.13955469
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.11942773
11MYB_26560356_Chip-Seq_TH2_Human3.04712356
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.00677850
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.94363884
14MAF_26560356_Chip-Seq_TH1_Human2.56009265
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.55103732
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50923592
17MYB_26560356_Chip-Seq_TH1_Human2.49215339
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48558608
19UTX_26944678_Chip-Seq_JUKART_Human2.47336263
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36795119
21GATA3_27048872_Chip-Seq_THYMUS_Human2.28284081
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.21209470
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.10539744
24MAF_26560356_Chip-Seq_TH2_Human2.02671952
25SPI1_23547873_ChIP-Seq_NB4_Human1.96061743
26GATA3_26560356_Chip-Seq_TH2_Human1.89781771
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.87543461
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87514955
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.80431982
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78435711
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74228147
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70653769
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62137687
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60290407
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.52880178
36VDR_24763502_ChIP-Seq_THP-1_Human1.50686924
37GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50665764
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42174376
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.41909465
40BCL6_27268052_Chip-Seq_Bcells_Human1.39966880
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39402703
42VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.37133550
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36151945
44SCL_19346495_ChIP-Seq_HPC-7_Human1.32772951
45SPI1_23127762_ChIP-Seq_K562_Human1.29936937
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25840024
47RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25596003
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25149528
49BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21381726
50EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20176951
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20121749
52RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17923430
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15818862
54VDR_21846776_ChIP-Seq_THP-1_Human1.15351854
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.15089558
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10737345
57MYC_22102868_ChIP-Seq_BL_Human1.06269719
58VDR_24787735_ChIP-Seq_THP-1_Human1.04718193
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03389695
60BCOR_27268052_Chip-Seq_Bcells_Human1.02644408
61TAF2_19829295_ChIP-Seq_ESCs_Human1.00227019
62SA1_27219007_Chip-Seq_Bcells_Human0.99544238
63RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98377920
64E2F1_20622854_ChIP-Seq_HELA_Human0.97464067
65YY1_22570637_ChIP-Seq_MALME-3M_Human0.97200156
66SPI1_20517297_ChIP-Seq_HL60_Human0.96998088
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95848840
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95818505
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94689989
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94551601
71MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94194898
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93345801
73P300_27268052_Chip-Seq_Bcells_Human0.92131884
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91970797
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91759766
76NANOG_20526341_ChIP-Seq_ESCs_Human0.89981478
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89399733
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89223666
79* CTCF_20526341_ChIP-Seq_ESCs_Human0.88051076
80GATA3_26560356_Chip-Seq_TH1_Human0.87420687
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87399946
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86502687
83CIITA_25753668_ChIP-Seq_RAJI_Human0.86427687
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83818449
85EGR1_19032775_ChIP-ChIP_M12_Human0.80405117
86HTT_18923047_ChIP-ChIP_STHdh_Human0.80377555
87P68_20966046_ChIP-Seq_HELA_Human0.79455439
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77893650
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76630842
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75152893
91RAC3_21632823_ChIP-Seq_H3396_Human0.74190004
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72402759
93PHF8_20622854_ChIP-Seq_HELA_Human0.72197197
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.71877272
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71787126
96DROSHA_22980978_ChIP-Seq_HELA_Human0.71619819
97SA1_27219007_Chip-Seq_ERYTHROID_Human0.70966289
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.70937960
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.70688324
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.70040557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.21006266
2MP0006082_CNS_inflammation4.85710704
3MP0001835_abnormal_antigen_presentation4.19676710
4MP0003763_abnormal_thymus_physiology3.80643133
5MP0009785_altered_susceptibility_to3.66848036
6MP0003436_decreased_susceptibility_to3.09685401
7MP0001800_abnormal_humoral_immune3.08225726
8MP0001790_abnormal_immune_system3.07254060
9MP0005387_immune_system_phenotype3.07254060
10MP0005000_abnormal_immune_tolerance3.06863146
11MP0005025_abnormal_response_to3.06463657
12MP0009333_abnormal_splenocyte_physiolog2.95679684
13MP0000685_abnormal_immune_system2.87719656
14MP0002166_altered_tumor_susceptibility2.78770258
15MP0002420_abnormal_adaptive_immunity2.78498039
16MP0002723_abnormal_immune_serum2.72723770
17MP0001819_abnormal_immune_cell2.70574889
18MP0003724_increased_susceptibility_to2.62442208
19MP0001873_stomach_inflammation2.60801107
20MP0002452_abnormal_antigen_presenting2.45663826
21MP0002419_abnormal_innate_immunity2.39500149
22MP0002132_abnormal_respiratory_system2.35885662
23MP0002405_respiratory_system_inflammati2.25917325
24MP0003866_abnormal_defecation2.15802163
25MP0002398_abnormal_bone_marrow2.11038152
26MP0000716_abnormal_immune_system2.10515938
27MP0010155_abnormal_intestine_physiology2.06219055
28MP0002148_abnormal_hypersensitivity_rea2.05140077
29MP0002006_tumorigenesis2.03205471
30MP0001845_abnormal_inflammatory_respons1.82116022
31MP0000703_abnormal_thymus_morphology1.77040823
32MP0000689_abnormal_spleen_morphology1.68698749
33MP0002722_abnormal_immune_system1.65952415
34MP0005464_abnormal_platelet_physiology1.63412484
35MP0002429_abnormal_blood_cell1.62411587
36MP0003300_gastrointestinal_ulcer1.60071975
37MP0000858_altered_metastatic_potential1.46289048
38MP0003448_altered_tumor_morphology1.41875179
39MP0008469_abnormal_protein_level1.41082314
40MP0003045_fibrosis1.40891976
41MP0001533_abnormal_skeleton_physiology1.37278704
42MP0004947_skin_inflammation1.32144894
43MP0002933_joint_inflammation1.32130661
44MP0002277_abnormal_respiratory_mucosa1.20717864
45MP0004381_abnormal_hair_follicle1.19844461
46MP0003646_muscle_fatigue1.18379450
47MP0003183_abnormal_peptide_metabolism1.17017130
48MP0005166_decreased_susceptibility_to1.11513454
49MP0003878_abnormal_ear_physiology1.06130220
50MP0005377_hearing/vestibular/ear_phenot1.06130220
51MP0003690_abnormal_glial_cell1.03402101
52MP0009763_increased_sensitivity_to1.02940932
53MP0001851_eye_inflammation1.02025425
54MP0004883_abnormal_blood_vessel1.01070486
55MP0002163_abnormal_gland_morphology0.97104757
56MP0005310_abnormal_salivary_gland0.89658365
57MP0001663_abnormal_digestive_system0.87043010
58MP0002653_abnormal_ependyma_morphology0.84398053
59MP0009764_decreased_sensitivity_to0.84303136
60MP0005645_abnormal_hypothalamus_physiol0.84200239
61MP0001919_abnormal_reproductive_system0.83346964
62MP0002693_abnormal_pancreas_physiology0.82091201
63MP0000490_abnormal_crypts_of0.81711494
64MP0005075_abnormal_melanosome_morpholog0.79359814
65MP0002998_abnormal_bone_remodeling0.76422819
66MP0003303_peritoneal_inflammation0.73626691
67MP0002019_abnormal_tumor_incidence0.70348400
68MP0001986_abnormal_taste_sensitivity0.66911076
69MP0001853_heart_inflammation0.66615991
70MP0008873_increased_physiological_sensi0.65643797
71MP0002254_reproductive_system_inflammat0.65584127
72MP0002138_abnormal_hepatobiliary_system0.63190072
73MP0000920_abnormal_myelination0.62941025
74MP0001348_abnormal_lacrimal_gland0.61883764
75MP0005164_abnormal_response_to0.61072563
76MP0000465_gastrointestinal_hemorrhage0.60277821
77MP0001765_abnormal_ion_homeostasis0.60011564
78MP0002102_abnormal_ear_morphology0.58338698
79MP0003787_abnormal_imprinting0.58236836
80MP0008872_abnormal_physiological_respon0.57474743
81MP0001905_abnormal_dopamine_level0.53338647
82MP0002136_abnormal_kidney_physiology0.52249013
83MP0004130_abnormal_muscle_cell0.51794893
84MP0003075_altered_response_to0.50696881
85MP0009643_abnormal_urine_homeostasis0.49547237
86MP0004185_abnormal_adipocyte_glucose0.48697916
87MP0001501_abnormal_sleep_pattern0.48635413
88MP0005389_reproductive_system_phenotype0.45151540
89MP0004142_abnormal_muscle_tone0.44525605
90MP0005381_digestive/alimentary_phenotyp0.43849700
91MP0000249_abnormal_blood_vessel0.42418225
92MP0003795_abnormal_bone_structure0.42190718
93MP0009642_abnormal_blood_homeostasis0.42011670
94MP0002876_abnormal_thyroid_physiology0.41802081
95MP0005390_skeleton_phenotype0.41648589
96MP0003638_abnormal_response/metabolism_0.41176305
97MP0001119_abnormal_female_reproductive0.38702826
98MP0003252_abnormal_bile_duct0.37941385
99MP0003786_premature_aging0.37586621
100MP0005379_endocrine/exocrine_gland_phen0.35533594

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)6.54608907
2T lymphocytopenia (HP:0005403)6.39396911
3Elevated erythrocyte sedimentation rate (HP:0003565)5.98015787
4Increased IgM level (HP:0003496)5.28942031
5Abnormality of T cells (HP:0002843)4.98234947
6Autoimmune hemolytic anemia (HP:0001890)4.93239873
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.89953754
8Abnormality of macrophages (HP:0004311)4.64857327
9Myositis (HP:0100614)4.61322614
10Encephalitis (HP:0002383)4.56581380
11Hypoproteinemia (HP:0003075)4.41045016
12Stomatitis (HP:0010280)4.29426202
13Aplastic anemia (HP:0001915)4.24112981
14Nasal polyposis (HP:0100582)3.97768029
15Recurrent bacterial skin infections (HP:0005406)3.95033937
16Eczematoid dermatitis (HP:0000976)3.83532271
17Optic neuritis (HP:0100653)3.78654919
18Retrobulbar optic neuritis (HP:0100654)3.78654919
19Abnormality of eosinophils (HP:0001879)3.78583854
20Recurrent abscess formation (HP:0002722)3.77494564
21Eosinophilia (HP:0001880)3.76817155
22Autoimmune thrombocytopenia (HP:0001973)3.75923858
23Severe combined immunodeficiency (HP:0004430)3.73618738
24Meningitis (HP:0001287)3.70828781
25Recurrent fungal infections (HP:0002841)3.66090498
26Chronic mucocutaneous candidiasis (HP:0002728)3.62994604
27Recurrent cutaneous fungal infections (HP:0011370)3.62994604
28Orchitis (HP:0100796)3.60729290
29IgG deficiency (HP:0004315)3.59117540
30Abnormality of T cell physiology (HP:0011840)3.55808383
31Abnormality of cells of the lymphoid lineage (HP:0012140)3.44868245
32Hypergammaglobulinemia (HP:0010702)3.42663393
33Recurrent viral infections (HP:0004429)3.41685379
34Mediastinal lymphadenopathy (HP:0100721)3.41198843
35Lymphopenia (HP:0001888)3.37940634
36Granulocytopenia (HP:0001913)3.36370642
37Leukocytosis (HP:0001974)3.31167224
38Abnormality of the nasal mucosa (HP:0000433)3.28720321
39Gastrointestinal infarctions (HP:0005244)3.28118027
40Recurrent bronchitis (HP:0002837)3.21442915
41Recurrent skin infections (HP:0001581)3.15522233
42Pustule (HP:0200039)3.12457546
43Pulmonary infiltrates (HP:0002113)3.08897197
44Increased IgE level (HP:0003212)3.04707642
45Vasculitis (HP:0002633)3.04094091
46Hemiplegia (HP:0002301)3.03706297
47Keratoconjunctivitis (HP:0001096)3.03697677
48Hypochromic anemia (HP:0001931)3.02840079
49Chronic diarrhea (HP:0002028)2.98804386
50Combined immunodeficiency (HP:0005387)2.95341823
51Acute hepatic failure (HP:0006554)2.93716588
52Agammaglobulinemia (HP:0004432)2.87232278
53Spontaneous hematomas (HP:0007420)2.86938944
54Chronic obstructive pulmonary disease (HP:0006510)2.83629435
55Obstructive lung disease (HP:0006536)2.83629435
56Keratoconjunctivitis sicca (HP:0001097)2.82354305
57Chest pain (HP:0100749)2.79773398
58IgM deficiency (HP:0002850)2.74507747
59Chronic otitis media (HP:0000389)2.69573174
60Panhypogammaglobulinemia (HP:0003139)2.66121477
61Joint swelling (HP:0001386)2.62457288
62Thyroiditis (HP:0100646)2.59691370
63Recurrent gram-negative bacterial infections (HP:0005420)2.58466884
64Lymphoma (HP:0002665)2.54177091
65Urticaria (HP:0001025)2.36517503
66Abnormality of B cell number (HP:0010975)2.35779100
67Arterial thrombosis (HP:0004420)2.35359039
68Inflammation of the large intestine (HP:0002037)2.34837377
69Pulmonary embolism (HP:0002204)2.27420868
70Hemoptysis (HP:0002105)2.27182033
71Microcytic anemia (HP:0001935)2.20213984
72Hypochromic microcytic anemia (HP:0004840)2.16870708
733-Methylglutaconic aciduria (HP:0003535)2.15690096
74Gastrointestinal inflammation (HP:0004386)2.14436662
75Gingival bleeding (HP:0000225)2.12213809
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07472632
77Gangrene (HP:0100758)2.07380382
78Increased serum ferritin (HP:0003281)2.06289685
79Anorexia (HP:0002039)2.05505564
80Pancytopenia (HP:0001876)1.98333224
81Bronchitis (HP:0012387)1.94471751
82Severe visual impairment (HP:0001141)1.92787346
83Chronic sinusitis (HP:0011109)1.92343050
84Epistaxis (HP:0000421)1.91699410
85Amyotrophic lateral sclerosis (HP:0007354)1.90737043
86Episodic fever (HP:0001954)1.87728839
87Recurrent otitis media (HP:0000403)1.86895795
88Keratitis (HP:0000491)1.86758112
89Abnormality of the pleura (HP:0002103)1.86367655
90Prolonged bleeding time (HP:0003010)1.84993378
91Abnormality of pyrimidine metabolism (HP:0004353)1.83747483
92Hypoplasia of the thymus (HP:0000778)1.83639105
93Congenital stationary night blindness (HP:0007642)1.79950975
94Glomerulopathy (HP:0100820)1.76535226
95B lymphocytopenia (HP:0010976)1.75239558
96Tetany (HP:0001281)1.74612659
97Hyponatremia (HP:0002902)1.74187928
98Abnormality of the prostate (HP:0008775)1.74149370
99Increased CSF protein (HP:0002922)1.72130578
100Attenuation of retinal blood vessels (HP:0007843)1.71190225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.54965852
2KDR4.59648713
3TESK24.33664833
4TXK3.84346898
5TAOK33.57864632
6ZAP702.96435619
7ITK2.75760979
8TESK12.66707156
9MAP3K112.51129906
10FES2.36008597
11TNK22.35469967
12RIPK42.24997575
13CSK2.13820911
14LIMK11.98384105
15BTK1.83120982
16SYK1.76138131
17IRAK41.75974330
18TLK11.74858750
19TEC1.70314954
20LCK1.51317199
21SCYL21.49479269
22BLK1.43496355
23GRK61.40238197
24MAP2K61.35445751
25PIK3CG1.35199616
26MAP3K121.33428796
27TYK21.27284346
28MST41.25227702
29GRK71.25132645
30TBK11.24541169
31IKBKE1.21626939
32ZAK1.20116357
33PRKCQ1.16733831
34ADRBK21.10026932
35MARK31.09546633
36EPHB11.09459153
37LYN1.07900262
38HCK1.06709975
39CAMKK21.06242092
40JAK31.01313555
41TGFBR21.00672462
42JAK10.98362860
43MAP2K30.97628208
44PIM10.95617937
45BMPR20.94899981
46STK100.93548807
47CSF1R0.87325570
48CAMKK10.86742668
49PASK0.83797125
50WNK40.83065985
51CLK10.82992948
52TAOK20.82900417
53PTK2B0.79692082
54IKBKB0.77270422
55PRPF4B0.75552619
56TAOK10.75342990
57MAP3K30.67783674
58MAP3K50.65283668
59VRK10.64859973
60MAP3K140.63780674
61BCKDK0.62802335
62KIT0.61931445
63PDK10.60375702
64FGR0.59482601
65MAPKAPK30.59274657
66FYN0.59202681
67JAK20.57094521
68MAP3K130.56020516
69LRRK20.54730287
70GRK50.51755473
71PRKCH0.50128133
72PIK3CA0.47161273
73ADRBK10.46463939
74CDK40.43420154
75MAPKAPK20.42742952
76PTK60.42223403
77ACVR1B0.41718761
78HIPK20.38860512
79PDGFRB0.37994245
80CDC42BPA0.35965016
81MAP3K10.35859658
82VRK20.35565350
83GRK10.35017210
84ERN10.32774250
85INSR0.31776854
86RPS6KA50.29227017
87DAPK10.28809205
88MAPK120.23863949
89MATK0.23246717
90IGF1R0.22751485
91ROCK10.22578596
92OXSR10.22388959
93MAPK110.21680014
94PAK10.19496294
95STK390.19448359
96MAPK70.18683839
97MAPK130.18262514
98ABL10.17293825
99MAP4K20.16629823
100MYLK0.15992074

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.58020265
2Graft-versus-host disease_Homo sapiens_hsa053324.99246345
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.14071474
4Antigen processing and presentation_Homo sapiens_hsa046123.86624934
5Allograft rejection_Homo sapiens_hsa053303.61668751
6Autoimmune thyroid disease_Homo sapiens_hsa053203.58846349
7T cell receptor signaling pathway_Homo sapiens_hsa046603.10468323
8Type I diabetes mellitus_Homo sapiens_hsa049402.90210776
9Hematopoietic cell lineage_Homo sapiens_hsa046402.43982498
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22331428
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11055234
12Measles_Homo sapiens_hsa051622.02113644
13Proteasome_Homo sapiens_hsa030502.00979921
14Viral myocarditis_Homo sapiens_hsa054161.97711615
15Malaria_Homo sapiens_hsa051441.92438346
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.87906790
17Leishmaniasis_Homo sapiens_hsa051401.61390548
18Osteoclast differentiation_Homo sapiens_hsa043801.60358133
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58754194
20Staphylococcus aureus infection_Homo sapiens_hsa051501.53877632
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49742186
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45950579
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45898076
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37928535
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28534016
26Shigellosis_Homo sapiens_hsa051311.25545493
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23969221
28B cell receptor signaling pathway_Homo sapiens_hsa046621.21775320
29Chemokine signaling pathway_Homo sapiens_hsa040621.19035895
30Herpes simplex infection_Homo sapiens_hsa051681.12646404
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.11711153
32Salmonella infection_Homo sapiens_hsa051321.07850307
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07834705
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.05581857
35Rheumatoid arthritis_Homo sapiens_hsa053231.03482929
36Tuberculosis_Homo sapiens_hsa051520.98639414
37Phototransduction_Homo sapiens_hsa047440.98630751
38Oxidative phosphorylation_Homo sapiens_hsa001900.92999335
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89839114
40Pertussis_Homo sapiens_hsa051330.86704849
41African trypanosomiasis_Homo sapiens_hsa051430.85155909
42Legionellosis_Homo sapiens_hsa051340.84231041
43TNF signaling pathway_Homo sapiens_hsa046680.84113681
44Influenza A_Homo sapiens_hsa051640.84035534
45Parkinsons disease_Homo sapiens_hsa050120.83811312
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83407994
47Asthma_Homo sapiens_hsa053100.79915285
48Apoptosis_Homo sapiens_hsa042100.78698521
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78472602
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.78415494
51Toxoplasmosis_Homo sapiens_hsa051450.77653101
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70242002
53Linoleic acid metabolism_Homo sapiens_hsa005910.67856813
54Epstein-Barr virus infection_Homo sapiens_hsa051690.66943096
55Platelet activation_Homo sapiens_hsa046110.63379395
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56834753
57Regulation of autophagy_Homo sapiens_hsa041400.56558441
58Phagosome_Homo sapiens_hsa041450.56109310
59Nitrogen metabolism_Homo sapiens_hsa009100.53482290
60Alzheimers disease_Homo sapiens_hsa050100.51853634
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51126824
62Ribosome_Homo sapiens_hsa030100.49977182
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47912632
64HTLV-I infection_Homo sapiens_hsa051660.46715882
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.46441320
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45053839
67Endocytosis_Homo sapiens_hsa041440.40681231
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40607540
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39878894
70RNA polymerase_Homo sapiens_hsa030200.36184437
71VEGF signaling pathway_Homo sapiens_hsa043700.35705040
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34957738
73Hepatitis B_Homo sapiens_hsa051610.34941944
74Olfactory transduction_Homo sapiens_hsa047400.32883854
75Systemic lupus erythematosus_Homo sapiens_hsa053220.29982198
76Caffeine metabolism_Homo sapiens_hsa002320.27112329
77Viral carcinogenesis_Homo sapiens_hsa052030.26095675
78MAPK signaling pathway_Homo sapiens_hsa040100.26055816
79Hepatitis C_Homo sapiens_hsa051600.23156914
80Arachidonic acid metabolism_Homo sapiens_hsa005900.22968409
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22810141
82Rap1 signaling pathway_Homo sapiens_hsa040150.21528106
83Cardiac muscle contraction_Homo sapiens_hsa042600.20169174
84Huntingtons disease_Homo sapiens_hsa050160.20056036
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19134134
86Collecting duct acid secretion_Homo sapiens_hsa049660.16380524
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14162747
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13115435
89Ras signaling pathway_Homo sapiens_hsa040140.12111129
90Acute myeloid leukemia_Homo sapiens_hsa052210.11077334
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.08616761
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.07947581
93Renin secretion_Homo sapiens_hsa049240.05139265
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.05094719
95Sulfur metabolism_Homo sapiens_hsa009200.04906645
96Mineral absorption_Homo sapiens_hsa049780.04858105
97Non-small cell lung cancer_Homo sapiens_hsa052230.04784896
98FoxO signaling pathway_Homo sapiens_hsa040680.04772359
99Ether lipid metabolism_Homo sapiens_hsa005650.01951409
100ABC transporters_Homo sapiens_hsa020100.01807192

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