GUSBP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1arginine catabolic process (GO:0006527)5.05866661
2response to pheromone (GO:0019236)4.67233209
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.59507311
4tachykinin receptor signaling pathway (GO:0007217)4.36136323
5negative regulation of calcium ion transport into cytosol (GO:0010523)4.12430412
6DNA integration (GO:0015074)4.12067740
7platelet dense granule organization (GO:0060155)4.02770522
8respiratory chain complex IV assembly (GO:0008535)3.90473018
9positive regulation of cell size (GO:0045793)3.88268913
10metallo-sulfur cluster assembly (GO:0031163)3.78502202
11iron-sulfur cluster assembly (GO:0016226)3.78502202
12positive regulation of mitochondrial fission (GO:0090141)3.75678347
13epithelial cilium movement (GO:0003351)3.65115041
14arginine metabolic process (GO:0006525)3.64618443
15exogenous drug catabolic process (GO:0042738)3.58940844
16drug catabolic process (GO:0042737)3.58073180
17negative regulation of neurotransmitter transport (GO:0051589)3.57491820
18regulation of neurotransmitter uptake (GO:0051580)3.57264220
19positive regulation of guanylate cyclase activity (GO:0031284)3.56981110
20L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.56691659
21positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.53879321
22cytochrome complex assembly (GO:0017004)3.51658902
23pyrimidine nucleobase catabolic process (GO:0006208)3.49607592
24regulation of cilium movement (GO:0003352)3.48323255
25water-soluble vitamin biosynthetic process (GO:0042364)3.44351774
26mannosylation (GO:0097502)3.43344407
27ubiquinone biosynthetic process (GO:0006744)3.41763838
28response to lipoprotein particle (GO:0055094)3.40829871
29nonmotile primary cilium assembly (GO:0035058)3.31701295
30regulation of mitochondrial translation (GO:0070129)3.30375525
31positive regulation of action potential (GO:0045760)3.29507999
32retinal cone cell development (GO:0046549)3.27205933
33C-terminal protein lipidation (GO:0006501)3.15639557
34ubiquinone metabolic process (GO:0006743)3.12405198
35regulation of guanylate cyclase activity (GO:0031282)3.11437914
36C4-dicarboxylate transport (GO:0015740)3.10529779
37peptidyl-histidine modification (GO:0018202)3.09522779
38positive regulation of mRNA catabolic process (GO:0061014)3.08358391
39CTP biosynthetic process (GO:0006241)3.07119337
40CTP metabolic process (GO:0046036)3.07119337
41amino acid salvage (GO:0043102)3.03900798
42L-methionine salvage (GO:0071267)3.03900798
43L-methionine biosynthetic process (GO:0071265)3.03900798
44axoneme assembly (GO:0035082)3.03738422
45cellular ketone body metabolic process (GO:0046950)3.03586724
46limb bud formation (GO:0060174)3.02813885
47regulation of action potential (GO:0098900)3.01605680
48histone H2A acetylation (GO:0043968)3.00879492
49somite development (GO:0061053)3.00401880
50preassembly of GPI anchor in ER membrane (GO:0016254)2.99770061
51regulation of nuclear cell cycle DNA replication (GO:0033262)2.96035149
52photoreceptor cell maintenance (GO:0045494)2.95743765
53S-adenosylmethionine metabolic process (GO:0046500)2.95681760
54glial cell proliferation (GO:0014009)2.92477406
55nucleobase catabolic process (GO:0046113)2.91229648
56mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.90838300
57positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.90838300
58C-terminal protein amino acid modification (GO:0018410)2.89706770
59glyoxylate metabolic process (GO:0046487)2.88129564
60negative regulation of neurological system process (GO:0031645)2.86906098
61establishment of protein localization to Golgi (GO:0072600)2.86297583
62regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.84736926
63regulation of mRNA catabolic process (GO:0061013)2.82287278
64neural tube formation (GO:0001841)2.81922975
65quinone biosynthetic process (GO:1901663)2.79920025
66GPI anchor metabolic process (GO:0006505)2.79522796
67ketone body metabolic process (GO:1902224)2.79185712
68peptidyl-cysteine modification (GO:0018198)2.78730385
69pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.77469085
70UMP metabolic process (GO:0046049)2.77469085
71pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.77469085
72UMP biosynthetic process (GO:0006222)2.77469085
73protein targeting to Golgi (GO:0000042)2.75707959
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75540680
75regulation of mitotic spindle checkpoint (GO:1903504)2.75540680
76pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.74682103
77positive regulation of receptor biosynthetic process (GO:0010870)2.73911806
78aggressive behavior (GO:0002118)2.73080518
79protein polyglutamylation (GO:0018095)2.72413438
80detection of light stimulus involved in sensory perception (GO:0050962)2.72333146
81detection of light stimulus involved in visual perception (GO:0050908)2.72333146
82L-fucose metabolic process (GO:0042354)2.71209727
83L-fucose catabolic process (GO:0042355)2.71209727
84fucose catabolic process (GO:0019317)2.71209727
85protein deneddylation (GO:0000338)2.70581289
86pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.69537212
87misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.69069967
88cilium movement (GO:0003341)2.66705499
89base-excision repair, AP site formation (GO:0006285)2.66431342
90establishment of mitochondrion localization (GO:0051654)2.65566807
91DNA deamination (GO:0045006)2.65248637
92branched-chain amino acid catabolic process (GO:0009083)2.64956560
93protein localization to Golgi apparatus (GO:0034067)2.64819643
94protein complex biogenesis (GO:0070271)2.64468274
95DNA double-strand break processing (GO:0000729)2.63578357
96negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62618862
97gamma-aminobutyric acid transport (GO:0015812)2.61351350
98replication fork processing (GO:0031297)2.59542394
99axonal fasciculation (GO:0007413)2.56077106
100cullin deneddylation (GO:0010388)2.54847728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela5.04383301
2EZH2_22144423_ChIP-Seq_EOC_Human4.27697499
3IGF1R_20145208_ChIP-Seq_DFB_Human3.20723807
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.96914494
5FUS_26573619_Chip-Seq_HEK293_Human2.77169100
6GBX2_23144817_ChIP-Seq_PC3_Human2.73489041
7VDR_22108803_ChIP-Seq_LS180_Human2.65017492
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54985369
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51528450
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45199429
11TAF15_26573619_Chip-Seq_HEK293_Human2.37631426
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28372064
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26646692
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16321922
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04947071
16EWS_26573619_Chip-Seq_HEK293_Human2.00564152
17ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98447172
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89900446
19CBP_20019798_ChIP-Seq_JUKART_Human1.84304761
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.84304761
21P300_19829295_ChIP-Seq_ESCs_Human1.81605256
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.79378646
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.77278132
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.70662840
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64352809
26NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64321164
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63505649
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62178406
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.60128200
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.59079580
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56808518
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56174288
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52140695
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51308195
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.47535452
36STAT3_23295773_ChIP-Seq_U87_Human1.47328425
37ER_23166858_ChIP-Seq_MCF-7_Human1.44171265
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42684495
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38407170
40VDR_23849224_ChIP-Seq_CD4+_Human1.36240650
41BCAT_22108803_ChIP-Seq_LS180_Human1.36089458
42TCF4_22108803_ChIP-Seq_LS180_Human1.34288337
43TP53_22573176_ChIP-Seq_HFKS_Human1.33838676
44ELK1_19687146_ChIP-ChIP_HELA_Human1.31012938
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29262333
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28573072
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28483619
48SMAD4_21799915_ChIP-Seq_A2780_Human1.27856641
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27673865
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25902159
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25671961
52SOX2_19829295_ChIP-Seq_ESCs_Human1.25663989
53NANOG_19829295_ChIP-Seq_ESCs_Human1.25663989
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23222348
55MYC_18940864_ChIP-ChIP_HL60_Human1.22904660
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22612314
57FOXP3_21729870_ChIP-Seq_TREG_Human1.21588913
58TCF4_23295773_ChIP-Seq_U87_Human1.19202980
59AR_25329375_ChIP-Seq_VCAP_Human1.18995333
60IRF1_19129219_ChIP-ChIP_H3396_Human1.18988742
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17472129
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.16435437
63ERA_21632823_ChIP-Seq_H3396_Human1.15631941
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14817222
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13181630
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.13135770
67CIITA_25753668_ChIP-Seq_RAJI_Human1.12352460
68RUNX2_22187159_ChIP-Seq_PCA_Human1.10270173
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08789278
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08457265
71RNF2_27304074_Chip-Seq_NSC_Mouse1.07539583
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06911436
73AR_20517297_ChIP-Seq_VCAP_Human1.05428539
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.04211511
75GATA3_26560356_Chip-Seq_TH2_Human1.03864076
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03094866
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02561531
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00959352
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.00912402
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00051362
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99761572
82KDM5A_27292631_Chip-Seq_BREAST_Human0.99404293
83SMAD4_21741376_ChIP-Seq_EPCs_Human0.99251793
84REST_21632747_ChIP-Seq_MESCs_Mouse0.99159469
85JUN_21703547_ChIP-Seq_K562_Human0.98414562
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97886560
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97675236
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.96938649
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96687275
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96503431
91SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96035566
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95635622
93GABP_19822575_ChIP-Seq_HepG2_Human0.94315311
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93352323
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.92359462
96NCOR_22424771_ChIP-Seq_293T_Human0.91682007
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91472025
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.91472025
99HOXB7_26014856_ChIP-Seq_BT474_Human0.90706400
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90191003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.37231471
2MP0002234_abnormal_pharynx_morphology4.15587212
3MP0005645_abnormal_hypothalamus_physiol3.08753022
4MP0008058_abnormal_DNA_repair2.69408328
5MP0003718_maternal_effect2.53601002
6MP0002822_catalepsy2.48305757
7MP0002736_abnormal_nociception_after2.42944112
8MP0001968_abnormal_touch/_nociception2.36090889
9MP0004043_abnormal_pH_regulation2.32110280
10MP0003880_abnormal_central_pattern2.31893287
11MP0001986_abnormal_taste_sensitivity2.26224845
12MP0001984_abnormal_olfaction2.22023845
13MP0002735_abnormal_chemical_nociception2.17357970
14MP0004133_heterotaxia1.95872809
15MP0005167_abnormal_blood-brain_barrier1.94366624
16MP0005551_abnormal_eye_electrophysiolog1.93258703
17MP0008872_abnormal_physiological_respon1.85159234
18MP0010368_abnormal_lymphatic_system1.84148322
19MP0002102_abnormal_ear_morphology1.82395016
20MP0005253_abnormal_eye_physiology1.80045221
21MP0002638_abnormal_pupillary_reflex1.80025752
22MP0006072_abnormal_retinal_apoptosis1.78579212
23MP0008877_abnormal_DNA_methylation1.77549030
24MP0000566_synostosis1.75271171
25MP0004233_abnormal_muscle_weight1.74595823
26MP0000372_irregular_coat_pigmentation1.68864347
27MP0001529_abnormal_vocalization1.65637975
28MP0006276_abnormal_autonomic_nervous1.65432255
29MP0001764_abnormal_homeostasis1.62135717
30MP0005075_abnormal_melanosome_morpholog1.57058811
31MP0002837_dystrophic_cardiac_calcinosis1.50876368
32MP0005499_abnormal_olfactory_system1.49692081
33MP0005394_taste/olfaction_phenotype1.49692081
34MP0008789_abnormal_olfactory_epithelium1.46636816
35MP0001919_abnormal_reproductive_system1.46492410
36MP0008995_early_reproductive_senescence1.40418379
37MP0003011_delayed_dark_adaptation1.38137577
38MP0000516_abnormal_urinary_system1.37994392
39MP0005367_renal/urinary_system_phenotyp1.37994392
40MP0009745_abnormal_behavioral_response1.37254920
41MP0005670_abnormal_white_adipose1.35760916
42MP0010386_abnormal_urinary_bladder1.34798874
43MP0003195_calcinosis1.30129569
44MP0002751_abnormal_autonomic_nervous1.27085259
45MP0001486_abnormal_startle_reflex1.27078082
46MP0001970_abnormal_pain_threshold1.24783106
47MP0005423_abnormal_somatic_nervous1.24266286
48MP0008775_abnormal_heart_ventricle1.23105096
49MP0002734_abnormal_mechanical_nocicepti1.20524669
50MP0009046_muscle_twitch1.16565517
51MP0004924_abnormal_behavior1.16258536
52MP0005386_behavior/neurological_phenoty1.16258536
53MP0003787_abnormal_imprinting1.12107215
54MP0005389_reproductive_system_phenotype1.08788399
55MP0002233_abnormal_nose_morphology1.06156403
56MP0000631_abnormal_neuroendocrine_gland1.05951942
57MP0001501_abnormal_sleep_pattern1.05241294
58MP0005084_abnormal_gallbladder_morpholo1.05099648
59MP0002272_abnormal_nervous_system1.02851498
60MP0000569_abnormal_digit_pigmentation1.01161730
61MP0004270_analgesia0.99317177
62MP0004084_abnormal_cardiac_muscle0.98761134
63MP0004858_abnormal_nervous_system0.97640196
64MP0003698_abnormal_male_reproductive0.96201552
65MP0003786_premature_aging0.95848322
66MP0005410_abnormal_fertilization0.94529100
67MP0002572_abnormal_emotion/affect_behav0.93947158
68MP0005395_other_phenotype0.91968375
69MP0004859_abnormal_synaptic_plasticity0.91500585
70MP0010329_abnormal_lipoprotein_level0.89758076
71MP0002938_white_spotting0.89659679
72MP0005220_abnormal_exocrine_pancreas0.88273724
73MP0000465_gastrointestinal_hemorrhage0.87911903
74MP0002557_abnormal_social/conspecific_i0.84271392
75MP0001929_abnormal_gametogenesis0.83898855
76MP0006035_abnormal_mitochondrial_morpho0.83829609
77MP0002067_abnormal_sensory_capabilities0.83547341
78MP0002653_abnormal_ependyma_morphology0.83345384
79MP0004147_increased_porphyrin_level0.82943710
80MP0002733_abnormal_thermal_nociception0.82880759
81MP0000955_abnormal_spinal_cord0.81571620
82MP0000778_abnormal_nervous_system0.81202712
83MP0004885_abnormal_endolymph0.80066610
84MP0004484_altered_response_of0.79215144
85MP0002752_abnormal_somatic_nervous0.78700074
86MP0005646_abnormal_pituitary_gland0.78494330
87MP0004811_abnormal_neuron_physiology0.77392073
88MP0004142_abnormal_muscle_tone0.76716916
89MP0001756_abnormal_urination0.74474638
90MP0003635_abnormal_synaptic_transmissio0.73813333
91MP0001119_abnormal_female_reproductive0.72507913
92MP0000647_abnormal_sebaceous_gland0.72099996
93MP0001905_abnormal_dopamine_level0.71656102
94MP0000383_abnormal_hair_follicle0.71197567
95MP0002064_seizures0.70405554
96MP0000653_abnormal_sex_gland0.69887381
97MP0002882_abnormal_neuron_morphology0.69863317
98MP0005391_vision/eye_phenotype0.69159399
99MP0003121_genomic_imprinting0.68647531
100MP0001324_abnormal_eye_pigmentation0.68293844

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.17792649
2Anal stenosis (HP:0002025)3.86272445
3Medial flaring of the eyebrow (HP:0010747)3.45381842
4Lip pit (HP:0100267)3.43435474
5Gait imbalance (HP:0002141)3.40591258
6Congenital primary aphakia (HP:0007707)3.38860672
7Hyperventilation (HP:0002883)3.31399841
8Depressed nasal tip (HP:0000437)3.10331666
9Chronic hepatic failure (HP:0100626)3.09134298
10Pancreatic fibrosis (HP:0100732)3.06240803
11Nephrogenic diabetes insipidus (HP:0009806)3.05137172
12True hermaphroditism (HP:0010459)2.98630199
13Short 5th finger (HP:0009237)2.92197814
14Sparse lateral eyebrow (HP:0005338)2.91160672
15Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.85190637
16Congenital stationary night blindness (HP:0007642)2.77489920
17Renal cortical cysts (HP:0000803)2.75559375
18Autoimmune thrombocytopenia (HP:0001973)2.72529958
19Abnormal biliary tract physiology (HP:0012439)2.66992349
20Bile duct proliferation (HP:0001408)2.66992349
21Intestinal fistula (HP:0100819)2.62606073
22Abnormality of the renal cortex (HP:0011035)2.60467005
23Cerebellar dysplasia (HP:0007033)2.59776346
24Atonic seizures (HP:0010819)2.57997470
25Posterior subcapsular cataract (HP:0007787)2.56997859
26Severe visual impairment (HP:0001141)2.52035407
27Poor coordination (HP:0002370)2.47375375
28Lissencephaly (HP:0001339)2.46658658
29Vaginal atresia (HP:0000148)2.45334315
30Nephronophthisis (HP:0000090)2.44875936
31Genital tract atresia (HP:0001827)2.44795928
32Molar tooth sign on MRI (HP:0002419)2.44168767
33Abnormality of midbrain morphology (HP:0002418)2.44168767
34Progressive microcephaly (HP:0000253)2.42320919
35Intestinal atresia (HP:0011100)2.35547371
36Type II lissencephaly (HP:0007260)2.26997762
37Abnormality of the renal medulla (HP:0100957)2.26051222
38Cystic liver disease (HP:0006706)2.24183518
39Pachygyria (HP:0001302)2.22990087
40Ectropion (HP:0000656)2.22148728
41Abnormal mitochondria in muscle tissue (HP:0008316)2.21703503
42Methylmalonic acidemia (HP:0002912)2.21245015
43Hyperglycinemia (HP:0002154)2.20968703
44Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.19467327
45Short 1st metacarpal (HP:0010034)2.19467327
46Hepatic necrosis (HP:0002605)2.16842290
47Ureteral stenosis (HP:0000071)2.11216714
48Absent speech (HP:0001344)2.09310670
49Hepatocellular necrosis (HP:0001404)2.09224234
50Decreased central vision (HP:0007663)2.07281177
51Attenuation of retinal blood vessels (HP:0007843)2.07041054
52Acute encephalopathy (HP:0006846)2.04828563
53Postaxial hand polydactyly (HP:0001162)2.03570914
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03233704
55Abnormal protein N-linked glycosylation (HP:0012347)2.03233704
56Abnormal protein glycosylation (HP:0012346)2.03233704
57Abnormal glycosylation (HP:0012345)2.03233704
58Methylmalonic aciduria (HP:0012120)2.02021890
593-Methylglutaconic aciduria (HP:0003535)2.01437620
60Febrile seizures (HP:0002373)2.01344481
61Popliteal pterygium (HP:0009756)1.99265459
62Acute necrotizing encephalopathy (HP:0006965)1.96626162
63Long clavicles (HP:0000890)1.96280785
64Occipital encephalocele (HP:0002085)1.95832198
65Ureteral obstruction (HP:0006000)1.95305392
66Type 2 muscle fiber atrophy (HP:0003554)1.95218229
67Anal atresia (HP:0002023)1.94010932
68Abnormality of macular pigmentation (HP:0008002)1.92753086
69Retinal dysplasia (HP:0007973)1.91196059
70Increased serum lactate (HP:0002151)1.91079228
71Anencephaly (HP:0002323)1.90993254
72Poor head control (HP:0002421)1.90023800
73Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89725019
74Abnormality of the 1st metacarpal (HP:0010009)1.89126882
75Abnormality of the fingertips (HP:0001211)1.87889652
76Mitochondrial inheritance (HP:0001427)1.87139797
77Ectopic kidney (HP:0000086)1.86972023
78Broad foot (HP:0001769)1.86872124
79Supernumerary spleens (HP:0009799)1.86642815
80Specific learning disability (HP:0001328)1.86033978
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.85778168
82Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85086297
83Abolished electroretinogram (ERG) (HP:0000550)1.84884243
84Increased CSF lactate (HP:0002490)1.84494706
85Increased corneal curvature (HP:0100692)1.84147910
86Keratoconus (HP:0000563)1.84147910
87Tented upper lip vermilion (HP:0010804)1.80722460
88Bifid tongue (HP:0010297)1.80484804
89Proximal tubulopathy (HP:0000114)1.80273695
90Abnormal rod and cone electroretinograms (HP:0008323)1.80060823
91Sclerocornea (HP:0000647)1.79991335
92Hemiparesis (HP:0001269)1.78653655
93Postaxial foot polydactyly (HP:0001830)1.78609051
94Fibular aplasia (HP:0002990)1.77838434
95Abnormal respiratory epithelium morphology (HP:0012253)1.77280298
96Abnormal respiratory motile cilium morphology (HP:0005938)1.77280298
97Short phalanx of the thumb (HP:0009660)1.76502947
98Abnormality of the parathyroid morphology (HP:0011766)1.75567494
99Tubulointerstitial nephritis (HP:0001970)1.75395162
100Abnormality of the labia minora (HP:0012880)1.74901573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.11505282
2PINK14.09291411
3STK243.17871486
4STK393.06015162
5WNK42.84281667
6CCNB12.77934201
7ZAK2.67538337
8FRK2.60354844
9MAPK132.56515387
10BCKDK2.48084730
11MAP3K42.15376664
12WNK32.13276664
13BMPR1B2.06794535
14NUAK12.01346691
15CASK1.86797025
16MAPKAPK31.86510768
17MAP2K71.81699225
18MARK11.81676868
19TAOK31.73302561
20GRK11.57109147
21CSNK1G31.53105036
22TNIK1.48670152
23TRIM281.42052011
24CSNK1A1L1.41083991
25FLT31.37601090
26CSNK1G21.31348960
27CSNK1G11.28096476
28PDK21.23645528
29BCR1.20454152
30EPHA41.19593394
31DYRK31.17734121
32ERBB31.17102401
33ACVR1B1.14537766
34INSRR1.13962398
35ADRBK21.13944244
36CAMKK21.08953637
37SRPK11.08085618
38EEF2K1.05862796
39AKT31.04928315
40JAK30.98132820
41TXK0.95948017
42EPHA30.95238241
43PAK30.89678963
44CAMK10.88889655
45PRKCQ0.88014232
46KIT0.87350124
47CAMK40.87192739
48PIM20.78345704
49NTRK20.77289385
50MAP3K20.75781762
51PRKCE0.72779438
52MAP3K30.70008018
53FER0.68227101
54KDR0.66142578
55DYRK20.65835259
56ILK0.65136273
57CDC70.63291863
58EIF2AK30.62638342
59MAPKAPK50.61381580
60CHEK20.61350927
61DYRK1A0.57164356
62OXSR10.56302221
63PLK20.53923968
64BRD40.53493285
65VRK10.48092233
66PIK3CG0.47704009
67PRKCG0.45886995
68DAPK20.45326950
69MUSK0.45224666
70CSNK1A10.42339278
71TEC0.41706339
72BRSK20.41638542
73EPHB10.40210468
74RPS6KA50.39370598
75ADRBK10.37878540
76MINK10.37156167
77PRKAA10.36620356
78TNK20.36227170
79MAP2K40.35151442
80PRKACA0.34075602
81DAPK10.33383514
82CSNK1D0.32986705
83NEK60.32677512
84PRKCZ0.32294851
85ATM0.30491215
86ATR0.29753968
87CAMK2A0.29164840
88PKN10.28440683
89PRKCI0.28376811
90RPS6KB10.26929701
91NTRK30.26288124
92ABL10.26273209
93EIF2AK20.22517016
94PRKCA0.22509208
95CDK50.22420777
96MAP3K50.21751440
97PRKACG0.20895164
98HCK0.20843917
99PRKACB0.20657461
100OBSCN0.19351091

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.33131152
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.31705986
3Phototransduction_Homo sapiens_hsa047443.04140647
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.29300433
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27286675
6Non-homologous end-joining_Homo sapiens_hsa034502.27069454
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26043658
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21004590
9Selenocompound metabolism_Homo sapiens_hsa004502.14468401
10Butanoate metabolism_Homo sapiens_hsa006502.11601913
11Peroxisome_Homo sapiens_hsa041462.00497538
12Propanoate metabolism_Homo sapiens_hsa006401.88522338
13Fanconi anemia pathway_Homo sapiens_hsa034601.88082901
14Homologous recombination_Homo sapiens_hsa034401.82748336
15Olfactory transduction_Homo sapiens_hsa047401.75812584
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.75754966
17Taste transduction_Homo sapiens_hsa047421.72568292
18Nicotine addiction_Homo sapiens_hsa050331.69188596
19Arginine biosynthesis_Homo sapiens_hsa002201.68241116
20Regulation of autophagy_Homo sapiens_hsa041401.63880568
21Nitrogen metabolism_Homo sapiens_hsa009101.63485667
22Base excision repair_Homo sapiens_hsa034101.56778777
23Fatty acid elongation_Homo sapiens_hsa000621.51424450
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48415296
25RNA polymerase_Homo sapiens_hsa030201.46726271
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.43854401
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43146123
28Caffeine metabolism_Homo sapiens_hsa002321.40351412
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37119151
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31543397
31One carbon pool by folate_Homo sapiens_hsa006701.29941427
32Vitamin digestion and absorption_Homo sapiens_hsa049771.28286677
33Protein export_Homo sapiens_hsa030601.25465227
34Lysine degradation_Homo sapiens_hsa003101.21449255
35Linoleic acid metabolism_Homo sapiens_hsa005911.20690625
36Basal transcription factors_Homo sapiens_hsa030221.20568506
37RNA degradation_Homo sapiens_hsa030181.19106770
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14093197
39Primary immunodeficiency_Homo sapiens_hsa053401.13530305
40Pyrimidine metabolism_Homo sapiens_hsa002401.06055038
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05215801
42N-Glycan biosynthesis_Homo sapiens_hsa005101.03482867
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03214133
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02513428
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.01234485
46Fatty acid metabolism_Homo sapiens_hsa012120.99831067
47Nucleotide excision repair_Homo sapiens_hsa034200.98942923
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96510518
49Ether lipid metabolism_Homo sapiens_hsa005650.95781817
50Arginine and proline metabolism_Homo sapiens_hsa003300.95449720
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.94691343
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92499238
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90901615
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.89668998
55Collecting duct acid secretion_Homo sapiens_hsa049660.87844987
56Sphingolipid metabolism_Homo sapiens_hsa006000.87524422
57Chemical carcinogenesis_Homo sapiens_hsa052040.87211003
58Oxidative phosphorylation_Homo sapiens_hsa001900.86346552
59Metabolic pathways_Homo sapiens_hsa011000.86160773
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86125847
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83881837
62ABC transporters_Homo sapiens_hsa020100.83555493
63Purine metabolism_Homo sapiens_hsa002300.81534834
64Biosynthesis of amino acids_Homo sapiens_hsa012300.81055178
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79326932
66RNA transport_Homo sapiens_hsa030130.78234514
67Steroid biosynthesis_Homo sapiens_hsa001000.78026451
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77463445
69Vitamin B6 metabolism_Homo sapiens_hsa007500.76073352
70Retinol metabolism_Homo sapiens_hsa008300.75316011
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73857329
72Parkinsons disease_Homo sapiens_hsa050120.73723902
73Tryptophan metabolism_Homo sapiens_hsa003800.73552039
74Salivary secretion_Homo sapiens_hsa049700.65971996
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61067174
76Dopaminergic synapse_Homo sapiens_hsa047280.59203062
77Arachidonic acid metabolism_Homo sapiens_hsa005900.58337999
78Circadian entrainment_Homo sapiens_hsa047130.58301048
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.57694056
80Proteasome_Homo sapiens_hsa030500.56705737
81Carbon metabolism_Homo sapiens_hsa012000.56076617
82GABAergic synapse_Homo sapiens_hsa047270.54878808
83Sulfur metabolism_Homo sapiens_hsa009200.53226803
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52745340
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49768880
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49008400
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47858637
88Huntingtons disease_Homo sapiens_hsa050160.47635617
89AMPK signaling pathway_Homo sapiens_hsa041520.45676934
90beta-Alanine metabolism_Homo sapiens_hsa004100.45327855
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43414748
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.42705596
93mRNA surveillance pathway_Homo sapiens_hsa030150.42684154
94Pyruvate metabolism_Homo sapiens_hsa006200.42630724
95Fat digestion and absorption_Homo sapiens_hsa049750.39970858
96Morphine addiction_Homo sapiens_hsa050320.37626698
97Fructose and mannose metabolism_Homo sapiens_hsa000510.35608634
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33249501
99Glycerolipid metabolism_Homo sapiens_hsa005610.33177787
100Long-term depression_Homo sapiens_hsa047300.32251666

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »