GUF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.52148047
2nuclear pore organization (GO:0006999)5.04840356
3definitive hemopoiesis (GO:0060216)4.79958562
4mitotic sister chromatid cohesion (GO:0007064)4.70710336
5polyketide metabolic process (GO:0030638)4.45033077
6doxorubicin metabolic process (GO:0044598)4.45033077
7daunorubicin metabolic process (GO:0044597)4.45033077
8ribosomal small subunit assembly (GO:0000028)4.28277579
9lymphoid progenitor cell differentiation (GO:0002320)4.27048705
10platelet dense granule organization (GO:0060155)4.14035343
11pore complex assembly (GO:0046931)3.94075758
12intra-S DNA damage checkpoint (GO:0031573)3.77809688
13tRNA methylation (GO:0030488)3.65628678
14double-strand break repair via nonhomologous end joining (GO:0006303)3.65270466
15non-recombinational repair (GO:0000726)3.65270466
16sister chromatid segregation (GO:0000819)3.60061237
17positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.55635891
18establishment of integrated proviral latency (GO:0075713)3.55586411
19positive regulation of mitotic sister chromatid separation (GO:1901970)3.54921983
20positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.54921983
21positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.54921983
22IMP metabolic process (GO:0046040)3.54129945
23mRNA splice site selection (GO:0006376)3.52837826
24IMP biosynthetic process (GO:0006188)3.52744153
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52659341
26chromatin remodeling at centromere (GO:0031055)3.46777435
27facial nerve structural organization (GO:0021612)3.46192064
28ribosome assembly (GO:0042255)3.45437409
29CENP-A containing nucleosome assembly (GO:0034080)3.45416439
30mitotic sister chromatid segregation (GO:0000070)3.37957934
31mitotic metaphase plate congression (GO:0007080)3.36049648
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33901751
33somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27822948
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.27822948
35mitotic nuclear envelope disassembly (GO:0007077)3.25544365
36protein localization to chromosome, centromeric region (GO:0071459)3.22886893
37DNA strand elongation involved in DNA replication (GO:0006271)3.20980395
38necroptotic process (GO:0070266)3.20034913
39histone H3-K4 trimethylation (GO:0080182)3.18337272
40kinetochore organization (GO:0051383)3.17719504
41mitotic chromosome condensation (GO:0007076)3.17439905
42secretory granule organization (GO:0033363)3.15675048
43DNA replication checkpoint (GO:0000076)3.13076250
44protein localization to kinetochore (GO:0034501)3.12755964
45pre-miRNA processing (GO:0031054)3.12230319
46positive regulation of chromosome segregation (GO:0051984)3.12219632
47DNA duplex unwinding (GO:0032508)3.10417114
48regulation of histone H3-K27 methylation (GO:0061085)3.09606948
49regulation of translational fidelity (GO:0006450)3.08241701
50regulation of nuclear cell cycle DNA replication (GO:0033262)3.07957352
51DNA geometric change (GO:0032392)3.07145923
52negative regulation of DNA recombination (GO:0045910)3.07140357
53metaphase plate congression (GO:0051310)3.07099259
54urogenital system development (GO:0001655)3.06435333
55regulation of helicase activity (GO:0051095)3.05777290
56regulation of DNA endoreduplication (GO:0032875)3.03206228
57cranial nerve structural organization (GO:0021604)3.03165838
58DNA double-strand break processing (GO:0000729)3.03051752
59regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02550920
60L-fucose catabolic process (GO:0042355)3.02076718
61fucose catabolic process (GO:0019317)3.02076718
62L-fucose metabolic process (GO:0042354)3.02076718
63regulation of sister chromatid segregation (GO:0033045)3.00576213
64regulation of mitotic sister chromatid separation (GO:0010965)3.00576213
65regulation of mitotic sister chromatid segregation (GO:0033047)3.00576213
66nuclear envelope disassembly (GO:0051081)2.99923039
67membrane disassembly (GO:0030397)2.99923039
68regulation of RNA export from nucleus (GO:0046831)2.99840214
69DNA strand elongation (GO:0022616)2.99058053
70negative regulation of DNA-dependent DNA replication (GO:2000104)2.97760520
71meiotic chromosome segregation (GO:0045132)2.96862175
72regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96140658
73regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96140658
74postsynaptic membrane organization (GO:0001941)2.95899040
75megakaryocyte development (GO:0035855)2.94646069
76righting reflex (GO:0060013)2.94551072
77ribonucleoprotein complex disassembly (GO:0032988)2.92819498
78DNA damage response, detection of DNA damage (GO:0042769)2.92083477
79DNA replication initiation (GO:0006270)2.89706583
80mitotic spindle checkpoint (GO:0071174)2.89259525
81spindle checkpoint (GO:0031577)2.87890178
82regulation of chromosome segregation (GO:0051983)2.87562424
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87286124
84phospholipid scrambling (GO:0017121)2.87059162
85negative regulation of mitotic sister chromatid separation (GO:2000816)2.86982924
86negative regulation of sister chromatid segregation (GO:0033046)2.86982924
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86982924
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86982924
89negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86982924
90purine nucleobase biosynthetic process (GO:0009113)2.86771406
91negative regulation of chromosome segregation (GO:0051985)2.86748472
92peptidyl-lysine trimethylation (GO:0018023)2.84997770
93histone exchange (GO:0043486)2.84815669
94interkinetic nuclear migration (GO:0022027)2.84754425
95negative regulation of RNA splicing (GO:0033119)2.84283504
96maturation of 5.8S rRNA (GO:0000460)2.84140241
97DNA replication-independent nucleosome organization (GO:0034724)2.81964811
98DNA replication-independent nucleosome assembly (GO:0006336)2.81964811
99formation of translation preinitiation complex (GO:0001731)2.81879492
100poly(A)+ mRNA export from nucleus (GO:0016973)2.80726585
101regulation of centriole replication (GO:0046599)2.78159928
102histone H2A acetylation (GO:0043968)2.77245119
103mitotic spindle assembly checkpoint (GO:0007094)2.77114268
104nucleobase biosynthetic process (GO:0046112)2.75625661
105mature B cell differentiation involved in immune response (GO:0002313)2.74940895
106regulation of mRNA splicing, via spliceosome (GO:0048024)2.73879090
107negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.73384582
108ATP-dependent chromatin remodeling (GO:0043044)2.73078924
109spindle assembly checkpoint (GO:0071173)2.72878433
110regulation of mitotic spindle organization (GO:0060236)2.69946773
111RNA-dependent DNA replication (GO:0006278)2.69364194
112DNA integration (GO:0015074)2.69113735
113regulation of sister chromatid cohesion (GO:0007063)2.68930592
114negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.68790041
115establishment of chromosome localization (GO:0051303)2.68522409
116mitochondrial RNA metabolic process (GO:0000959)2.68319115
117mitotic G2/M transition checkpoint (GO:0044818)2.67471676
118DNA deamination (GO:0045006)2.66933813
119regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.66358598
120organelle disassembly (GO:1903008)2.66020159
121tRNA aminoacylation (GO:0043039)2.64534965
122amino acid activation (GO:0043038)2.64534965
123regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64457136
124cranial nerve morphogenesis (GO:0021602)2.64158834
125histone H3 deacetylation (GO:0070932)2.63997082
126DNA topological change (GO:0006265)2.63817742
127negative regulation of cell cycle G2/M phase transition (GO:1902750)2.63813615
128respiratory chain complex IV assembly (GO:0008535)2.63335536
129tRNA aminoacylation for protein translation (GO:0006418)2.61839903
130aminoglycoside antibiotic metabolic process (GO:0030647)2.61334502
131somatic recombination of immunoglobulin gene segments (GO:0016447)2.61050995
132regulation of regulatory T cell differentiation (GO:0045589)2.60574287
133fucosylation (GO:0036065)2.59551565
134folic acid-containing compound biosynthetic process (GO:0009396)2.59407073
135resolution of meiotic recombination intermediates (GO:0000712)2.58530110
136DNA ligation (GO:0006266)2.58470811
137regulation of centrosome cycle (GO:0046605)2.56613158
138ribosome biogenesis (GO:0042254)2.56548496
139regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.56183073
140L-serine metabolic process (GO:0006563)2.56169762
141regulation of non-canonical Wnt signaling pathway (GO:2000050)2.56088106
142developmental pigmentation (GO:0048066)2.55483738
143negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.54866754
144negative regulation of T-helper cell differentiation (GO:0045623)2.54866754
145regulation of translational termination (GO:0006449)2.54842076
146telomere maintenance via semi-conservative replication (GO:0032201)2.54392365
147DNA synthesis involved in DNA repair (GO:0000731)2.53846375
148endosome to pigment granule transport (GO:0043485)2.53433109
149endosome to melanosome transport (GO:0035646)2.53433109
150B cell differentiation (GO:0030183)2.53257155
151presynaptic membrane assembly (GO:0097105)2.52951572
152regulation of spindle organization (GO:0090224)2.52932071
153regulation of translational elongation (GO:0006448)2.52331906
154cytochrome complex assembly (GO:0017004)2.52228142
155cell differentiation involved in metanephros development (GO:0072202)2.52120128
156regulation of mitochondrial translation (GO:0070129)2.49647193
157preassembly of GPI anchor in ER membrane (GO:0016254)2.49014253
158neural tube formation (GO:0001841)2.48042363
159programmed necrotic cell death (GO:0097300)2.47480028
160lymph node development (GO:0048535)2.47250693
161startle response (GO:0001964)2.47108890
162telomere maintenance via recombination (GO:0000722)2.45716597
163negative regulation of transcription by competitive promoter binding (GO:0010944)2.43386200
164mitotic recombination (GO:0006312)2.42427469
165RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.42302435
166tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.42302435
167positive regulation of granulocyte differentiation (GO:0030854)2.42105855
168synapsis (GO:0007129)2.40413291
169response to pheromone (GO:0019236)2.39792347
170necrotic cell death (GO:0070265)2.39693337
171generation of neurons (GO:0048699)2.39531012
172regulation of pigment cell differentiation (GO:0050932)2.38606309
173maturation of SSU-rRNA (GO:0030490)2.37589284
174negative regulation of mRNA processing (GO:0050686)2.35932653
175pseudouridine synthesis (GO:0001522)2.34492471
176peptidyl-lysine methylation (GO:0018022)2.34037971
177histamine secretion (GO:0001821)2.33307465
178histamine transport (GO:0051608)2.32586253
179mature B cell differentiation (GO:0002335)2.32432295
180positive regulation of DNA-dependent DNA replication (GO:2000105)2.31561425
181DNA unwinding involved in DNA replication (GO:0006268)2.29869928
182RNA methylation (GO:0001510)2.27900689
183tRNA modification (GO:0006400)2.27459657
184translesion synthesis (GO:0019985)2.26057183
185positive regulation of histone methylation (GO:0031062)2.26002244
186toxin transport (GO:1901998)2.25764457
187response to interferon-beta (GO:0035456)2.25432003
188T cell differentiation in thymus (GO:0033077)2.24445294
189positive regulation of histone H3-K4 methylation (GO:0051571)2.23091878
190positive regulation of respiratory burst (GO:0060267)2.22921068

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.91362564
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.25448953
3EZH2_22144423_ChIP-Seq_EOC_Human4.22834788
4GBX2_23144817_ChIP-Seq_PC3_Human3.33780560
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18756846
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.12419540
7* MYC_18555785_ChIP-Seq_MESCs_Mouse2.96035187
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.87501821
9SCL_19346495_ChIP-Seq_HPC-7_Human2.71204262
10AR_21909140_ChIP-Seq_LNCAP_Human2.60107138
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50914885
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.50511765
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44240778
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42400157
15IGF1R_20145208_ChIP-Seq_DFB_Human2.39924819
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.27751111
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24201556
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.24029002
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.21832535
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21142896
21PADI4_21655091_ChIP-ChIP_MCF-7_Human2.20363981
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13651359
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12936168
24EWS_26573619_Chip-Seq_HEK293_Human2.12219487
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10176695
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.10136033
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08225268
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99221535
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96605669
30FUS_26573619_Chip-Seq_HEK293_Human1.94271554
31IRF1_19129219_ChIP-ChIP_H3396_Human1.94032791
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91190518
33* ETS1_20019798_ChIP-Seq_JURKAT_Human1.90777061
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89464842
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88634697
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86056740
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.85710867
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84169425
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82725440
40VDR_23849224_ChIP-Seq_CD4+_Human1.81746719
41TAF15_26573619_Chip-Seq_HEK293_Human1.79624811
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74909678
43GATA1_22025678_ChIP-Seq_K562_Human1.73101087
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.71285771
45* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70999390
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69059914
47DCP1A_22483619_ChIP-Seq_HELA_Human1.63119789
48* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62071165
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58149332
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54368569
51ZNF274_21170338_ChIP-Seq_K562_Hela1.53779685
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53092555
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52239239
54* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52029076
55* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50490346
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49586968
57TTF2_22483619_ChIP-Seq_HELA_Human1.49462558
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48239688
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.47501486
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46802276
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46625574
62GABP_19822575_ChIP-Seq_HepG2_Human1.45027570
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.44705866
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.44185060
65P53_22387025_ChIP-Seq_ESCs_Mouse1.43920189
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43166665
67P300_19829295_ChIP-Seq_ESCs_Human1.42493637
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42374553
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40632532
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.39951906
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39675723
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39548442
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39446171
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39170564
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38880874
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.38506957
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.38050031
78VDR_22108803_ChIP-Seq_LS180_Human1.37688526
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.35196995
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32571395
81P300_18555785_Chip-Seq_ESCs_Mouse1.30139147
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29999039
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.29898919
84NMYC_18555785_Chip-Seq_ESCs_Mouse1.29878278
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28368641
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28096305
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27287349
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.25321284
89CIITA_25753668_ChIP-Seq_RAJI_Human1.24829804
90XRN2_22483619_ChIP-Seq_HELA_Human1.24705297
91* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24201373
92RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23976816
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23630134
94IRF8_22096565_ChIP-ChIP_GC-B_Human1.23153470
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.22979159
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21582803
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21279402
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21159880
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20692740
100* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19969147
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19875240
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19483318
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18647243
104RNF2_27304074_Chip-Seq_NSC_Mouse1.17423593
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.15335455
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15257075
107ZFX_18555785_Chip-Seq_ESCs_Mouse1.13351512
108PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13304233
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11885822
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11506695
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.10249813
112CTCF_18555785_Chip-Seq_ESCs_Mouse1.09862678
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09647023
114SMAD4_21799915_ChIP-Seq_A2780_Human1.09011172
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08882943
116MYC_18940864_ChIP-ChIP_HL60_Human1.07305629
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07283536
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.06691101
119SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05564899
120* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05154187
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04812032
122SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04595928
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04588178
124KDM5A_27292631_Chip-Seq_BREAST_Human1.04183078
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03686050
126* TFEB_21752829_ChIP-Seq_HELA_Human1.03314269
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02405980
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02308290
129LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02159672
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02079648
131SOX2_18555785_Chip-Seq_ESCs_Mouse1.01525273
132FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99540523
133WT1_19549856_ChIP-ChIP_CCG9911_Human0.99231646
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.98732474
135PU1_27457419_Chip-Seq_LIVER_Mouse0.98626061
136ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98330508
137TCF4_23295773_ChIP-Seq_U87_Human0.97956091
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.97694385
139FOXP3_21729870_ChIP-Seq_TREG_Human0.97685010
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97601294
141SMAD_19615063_ChIP-ChIP_OVARY_Human0.97146640
142ELK1_19687146_ChIP-ChIP_HELA_Human0.97048699
143ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97027042
144KLF4_18555785_Chip-Seq_ESCs_Mouse0.96951684
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96945108
146AR_21572438_ChIP-Seq_LNCaP_Human0.96692936
147SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96427470
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95661146
149CBP_20019798_ChIP-Seq_JUKART_Human0.95661146
150SOX9_26525672_Chip-Seq_HEART_Mouse0.92940157
151POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90407941
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88377076
153GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85263751
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.84536974
155TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82883999
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82852988
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82577900
158CHD1_26751641_Chip-Seq_LNCaP_Human0.81661087
159FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81022051
160REST_19997604_ChIP-ChIP_NEURONS_Mouse0.80822611
161SOX17_20123909_ChIP-Seq_XEN_Mouse0.80161462
162ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79353048
163FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78197419
164CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77751657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.20391227
2MP0006292_abnormal_olfactory_placode3.95933354
3MP0005174_abnormal_tail_pigmentation3.85745529
4MP0004957_abnormal_blastocyst_morpholog3.14597997
5MP0005409_darkened_coat_color2.94924759
6MP0000569_abnormal_digit_pigmentation2.85137451
7MP0002396_abnormal_hematopoietic_system2.84714847
8MP0009379_abnormal_foot_pigmentation2.70778947
9MP0002095_abnormal_skin_pigmentation2.67590065
10MP0008058_abnormal_DNA_repair2.56618014
11MP0005075_abnormal_melanosome_morpholog2.42392140
12MP0000015_abnormal_ear_pigmentation2.34826084
13MP0005646_abnormal_pituitary_gland2.33954386
14MP0003787_abnormal_imprinting2.33431784
15MP0010094_abnormal_chromosome_stability2.21090606
16MP0004145_abnormal_muscle_electrophysio2.19813808
17MP0003890_abnormal_embryonic-extraembry2.13370849
18MP0008932_abnormal_embryonic_tissue2.03248977
19MP0009697_abnormal_copulation1.90465186
20MP0004808_abnormal_hematopoietic_stem1.88966512
21MP0003646_muscle_fatigue1.87392726
22MP0002102_abnormal_ear_morphology1.86733395
23MP0008877_abnormal_DNA_methylation1.84271881
24MP0001730_embryonic_growth_arrest1.80437004
25MP0000372_irregular_coat_pigmentation1.79070895
26MP0001986_abnormal_taste_sensitivity1.78073609
27MP0002938_white_spotting1.75533891
28MP0008057_abnormal_DNA_replication1.71443093
29MP0001661_extended_life_span1.71439337
30MP0008007_abnormal_cellular_replicative1.68686738
31MP0003941_abnormal_skin_development1.67683947
32MP0003718_maternal_effect1.65941107
33MP0002638_abnormal_pupillary_reflex1.63422546
34MP0003221_abnormal_cardiomyocyte_apopto1.62688597
35MP0005171_absent_coat_pigmentation1.59163725
36MP0004147_increased_porphyrin_level1.58058902
37MP0010234_abnormal_vibrissa_follicle1.53309899
38MP0003121_genomic_imprinting1.51089583
39MP0006035_abnormal_mitochondrial_morpho1.50521401
40MP0002075_abnormal_coat/hair_pigmentati1.50307189
41MP0000749_muscle_degeneration1.49803161
42MP0000631_abnormal_neuroendocrine_gland1.49728442
43MP0001672_abnormal_embryogenesis/_devel1.46882487
44MP0005380_embryogenesis_phenotype1.46882487
45MP0004233_abnormal_muscle_weight1.44646866
46MP0003567_abnormal_fetal_cardiomyocyte1.44421950
47MP0002084_abnormal_developmental_patter1.43326366
48MP0001486_abnormal_startle_reflex1.43170497
49MP0002269_muscular_atrophy1.42770054
50MP0001697_abnormal_embryo_size1.42166598
51MP0002009_preneoplasia1.41441839
52MP0004215_abnormal_myocardial_fiber1.41428940
53MP0005379_endocrine/exocrine_gland_phen1.40858676
54MP0004197_abnormal_fetal_growth/weight/1.38625540
55MP0006036_abnormal_mitochondrial_physio1.36876789
56MP0010352_gastrointestinal_tract_polyps1.35340622
57MP0003984_embryonic_growth_retardation1.34492937
58MP0006072_abnormal_retinal_apoptosis1.34261915
59MP0005671_abnormal_response_to1.32352521
60MP0000371_diluted_coat_color1.31587113
61MP0001529_abnormal_vocalization1.31490661
62MP0009672_abnormal_birth_weight1.30794705
63MP0002088_abnormal_embryonic_growth/wei1.30227970
64MP0003937_abnormal_limbs/digits/tail_de1.30218007
65MP0003136_yellow_coat_color1.29490802
66MP0001835_abnormal_antigen_presentation1.28787437
67MP0000751_myopathy1.28484376
68MP0001186_pigmentation_phenotype1.28336324
69MP0002837_dystrophic_cardiac_calcinosis1.27562215
70MP0005187_abnormal_penis_morphology1.26687806
71MP0000350_abnormal_cell_proliferation1.26387500
72MP0003111_abnormal_nucleus_morphology1.24955241
73MP0009703_decreased_birth_body1.17163893
74MP0002080_prenatal_lethality1.16829882
75MP0004859_abnormal_synaptic_plasticity1.16241345
76MP0000490_abnormal_crypts_of1.15853330
77MP0008789_abnormal_olfactory_epithelium1.15704727
78MP0003763_abnormal_thymus_physiology1.15477886
79MP0005423_abnormal_somatic_nervous1.14004151
80MP0002234_abnormal_pharynx_morphology1.11672509
81MP0000681_abnormal_thyroid_gland1.10792871
82MP0003880_abnormal_central_pattern1.10767554
83MP0000566_synostosis1.09816067
84MP0002177_abnormal_outer_ear1.09738352
85MP0002085_abnormal_embryonic_tissue1.09524947
86MP0010307_abnormal_tumor_latency1.08958863
87MP0002106_abnormal_muscle_physiology1.08293787
88MP0003656_abnormal_erythrocyte_physiolo1.06928128
89MP0005253_abnormal_eye_physiology1.06566086
90MP0001299_abnormal_eye_distance/1.06275870
91MP0000049_abnormal_middle_ear1.04103554
92MP0005645_abnormal_hypothalamus_physiol1.04065233
93MP0002233_abnormal_nose_morphology1.03410594
94MP0000678_abnormal_parathyroid_gland1.01418880
95MP0002557_abnormal_social/conspecific_i1.00882779
96MP0004381_abnormal_hair_follicle1.00627126
97MP0000465_gastrointestinal_hemorrhage1.00483657
98MP0003635_abnormal_synaptic_transmissio0.99109299
99MP0000747_muscle_weakness0.98923956
100MP0005499_abnormal_olfactory_system0.98869344
101MP0005394_taste/olfaction_phenotype0.98869344
102MP0004087_abnormal_muscle_fiber0.98854581
103MP0002249_abnormal_larynx_morphology0.98325897
104MP0002166_altered_tumor_susceptibility0.97225486
105MP0000026_abnormal_inner_ear0.96877719
106MP0005551_abnormal_eye_electrophysiolog0.96148008
107MP0003123_paternal_imprinting0.95452067
108MP0004134_abnormal_chest_morphology0.94555887
109MP0000358_abnormal_cell_content/0.94502921
110MP0002086_abnormal_extraembryonic_tissu0.93497300
111MP0000613_abnormal_salivary_gland0.93369928
112MP0003943_abnormal_hepatobiliary_system0.92323703
113MP0000759_abnormal_skeletal_muscle0.92114909
114MP0003119_abnormal_digestive_system0.91903205
115MP0004036_abnormal_muscle_relaxation0.91847429
116MP0002398_abnormal_bone_marrow0.89996038
117MP0001984_abnormal_olfaction0.88511145
118MP0009745_abnormal_behavioral_response0.88264466
119MP0004142_abnormal_muscle_tone0.88215315
120MP0000703_abnormal_thymus_morphology0.87038352
121MP0004084_abnormal_cardiac_muscle0.85774077
122MP0001293_anophthalmia0.85743380
123MP0002697_abnormal_eye_size0.85740048
124MP0004270_analgesia0.85277902
125MP0008995_early_reproductive_senescence0.84378767
126MP0001270_distended_abdomen0.83198888
127MP0002277_abnormal_respiratory_mucosa0.82989833
128MP0003077_abnormal_cell_cycle0.81922424
129MP0001963_abnormal_hearing_physiology0.81448170
130MP0003935_abnormal_craniofacial_develop0.79032322
131MP0002067_abnormal_sensory_capabilities0.78636239
132MP0010678_abnormal_skin_adnexa0.77874974
133MP0005369_muscle_phenotype0.77786135
134MP0002160_abnormal_reproductive_system0.77396557
135MP0001929_abnormal_gametogenesis0.77045870
136MP0003122_maternal_imprinting0.76759309
137MP0000647_abnormal_sebaceous_gland0.76667132
138MP0002111_abnormal_tail_morphology0.76604278
139MP0002751_abnormal_autonomic_nervous0.76107800
140MP0001324_abnormal_eye_pigmentation0.75760148
141MP0003861_abnormal_nervous_system0.75631074
142MP0003385_abnormal_body_wall0.75441077
143MP0000313_abnormal_cell_death0.75415438
144MP0001968_abnormal_touch/_nociception0.75360052
145MP0001502_abnormal_circadian_rhythm0.74293511
146MP0005266_abnormal_metabolism0.73373473
147MP0005391_vision/eye_phenotype0.73284705
148MP0001286_abnormal_eye_development0.72839662
149MP0001485_abnormal_pinna_reflex0.72481628
150MP0002877_abnormal_melanocyte_morpholog0.72336280
151MP0003315_abnormal_perineum_morphology0.72289626
152MP0003786_premature_aging0.71838183
153MP0002272_abnormal_nervous_system0.70850379
154MP0003879_abnormal_hair_cell0.69272625
155MP0002163_abnormal_gland_morphology0.68496709
156MP0002572_abnormal_emotion/affect_behav0.68238062
157MP0003693_abnormal_embryo_hatching0.67901698
158MP0005389_reproductive_system_phenotype0.67148243
159MP0001873_stomach_inflammation0.67000583
160MP0009785_altered_susceptibility_to0.64902170
161MP0002006_tumorigenesis0.64565102
162MP0002420_abnormal_adaptive_immunity0.64228880
163MP0002928_abnormal_bile_duct0.63729092
164MP0000516_abnormal_urinary_system0.63522268
165MP0005367_renal/urinary_system_phenotyp0.63522268
166MP0002210_abnormal_sex_determination0.63339345
167MP0001119_abnormal_female_reproductive0.62563235
168MP0001819_abnormal_immune_cell0.61347644
169MP0001919_abnormal_reproductive_system0.60166669

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.86115699
2Chromsome breakage (HP:0040012)4.55187939
3Aplastic anemia (HP:0001915)4.42807950
4Exercise-induced muscle cramps (HP:0003710)4.02394448
5Nemaline bodies (HP:0003798)3.83750558
6Muscle fiber inclusion bodies (HP:0100299)3.78827514
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.63930140
8Papillary thyroid carcinoma (HP:0002895)3.44771805
9Microvesicular hepatic steatosis (HP:0001414)3.30149510
10Hypothermia (HP:0002045)3.20292235
11Rimmed vacuoles (HP:0003805)3.18165567
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.10075973
13Cortical dysplasia (HP:0002539)3.00174610
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.95445791
15Hepatoblastoma (HP:0002884)2.90275376
16Reticulocytopenia (HP:0001896)2.86582249
17Abnormality of the preputium (HP:0100587)2.86398425
18Acute lymphatic leukemia (HP:0006721)2.84763003
19Thyroid carcinoma (HP:0002890)2.83001116
20Type I transferrin isoform profile (HP:0003642)2.82739596
21Meckel diverticulum (HP:0002245)2.78261744
22Abnormality of DNA repair (HP:0003254)2.75738599
23Abnormality of chromosome stability (HP:0003220)2.74953826
24Clubbing of toes (HP:0100760)2.72037634
25Abnormality of the ileum (HP:0001549)2.68573165
26Abnormality of the carotid arteries (HP:0005344)2.67001130
27Myelodysplasia (HP:0002863)2.64837242
28Subaortic stenosis (HP:0001682)2.60520893
29Abnormality of the left ventricular outflow tract (HP:0011103)2.60520893
30Intestinal atresia (HP:0011100)2.60191072
31Abnormality of the renal collecting system (HP:0004742)2.59376256
32Long clavicles (HP:0000890)2.58244630
33Thrombocytosis (HP:0001894)2.51476438
34Exercise-induced myalgia (HP:0003738)2.49492055
35Pancreatic islet-cell hyperplasia (HP:0004510)2.49088435
36Prolonged bleeding time (HP:0003010)2.47005236
37Abnormality of the labia minora (HP:0012880)2.46583618
38Birth length less than 3rd percentile (HP:0003561)2.45186362
39White forelock (HP:0002211)2.44347307
40Patchy hypopigmentation of hair (HP:0011365)2.43954737
41Protruding tongue (HP:0010808)2.42701718
42Myoglobinuria (HP:0002913)2.40714127
43Febrile seizures (HP:0002373)2.37908390
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.36688218
45Pheochromocytoma (HP:0002666)2.36583374
46Volvulus (HP:0002580)2.30840827
47True hermaphroditism (HP:0010459)2.30836672
48Rhabdomyosarcoma (HP:0002859)2.29598306
49Thyroid-stimulating hormone excess (HP:0002925)2.29405573
50Abnormal rod and cone electroretinograms (HP:0008323)2.28844995
51Nephroblastoma (Wilms tumor) (HP:0002667)2.27668809
52Colon cancer (HP:0003003)2.26178512
53Medulloblastoma (HP:0002885)2.23776529
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23454182
55Abnormality of alanine metabolism (HP:0010916)2.23454182
56Hyperalaninemia (HP:0003348)2.23454182
57Ependymoma (HP:0002888)2.22784273
58Duplicated collecting system (HP:0000081)2.22268116
59Duodenal stenosis (HP:0100867)2.21677806
60Small intestinal stenosis (HP:0012848)2.21677806
61Muscle hypertrophy of the lower extremities (HP:0008968)2.21536033
62Bone marrow hypocellularity (HP:0005528)2.20647506
63Abnormality of the hip-girdle musculature (HP:0001445)2.20402338
64Abnormality of the musculature of the pelvis (HP:0001469)2.20402338
65IgM deficiency (HP:0002850)2.20272767
66Absent/shortened dynein arms (HP:0200106)2.18212956
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.18212956
68Generalized hypopigmentation of hair (HP:0011358)2.16827293
69Shoulder girdle muscle weakness (HP:0003547)2.15709423
70Reduced antithrombin III activity (HP:0001976)2.15684606
71Calf muscle hypertrophy (HP:0008981)2.15555998
72Supernumerary spleens (HP:0009799)2.15216422
73Abnormal protein glycosylation (HP:0012346)2.15055101
74Abnormal glycosylation (HP:0012345)2.15055101
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15055101
76Abnormal protein N-linked glycosylation (HP:0012347)2.15055101
77Pancreatic fibrosis (HP:0100732)2.11835090
78Hyperglycinuria (HP:0003108)2.10013071
79Abnormality of the astrocytes (HP:0100707)2.09144941
80Astrocytoma (HP:0009592)2.09144941
81Embryonal renal neoplasm (HP:0011794)2.06691118
82Urinary urgency (HP:0000012)2.06664799
83Tubulointerstitial nephritis (HP:0001970)2.06654932
84Progressive muscle weakness (HP:0003323)2.04533292
85Attenuation of retinal blood vessels (HP:0007843)2.04261696
86Pallor (HP:0000980)2.03440033
87Chronic hepatic failure (HP:0100626)2.02999811
88Pancytopenia (HP:0001876)2.02850978
89Spinal cord lesions (HP:0100561)1.99593512
90Syringomyelia (HP:0003396)1.99593512
91Panhypogammaglobulinemia (HP:0003139)1.97440763
92Drooling (HP:0002307)1.97159153
93Severe visual impairment (HP:0001141)1.96827149
94Multiple enchondromatosis (HP:0005701)1.96636863
95Glioma (HP:0009733)1.96576801
96Increased serum pyruvate (HP:0003542)1.95224255
97Chronic otitis media (HP:0000389)1.95102655
98Abnormality of the heme biosynthetic pathway (HP:0010472)1.93984588
99Hyperinsulinemic hypoglycemia (HP:0000825)1.93198038
100Abnormality of the duodenum (HP:0002246)1.93050764
101Decreased central vision (HP:0007663)1.92387293
10211 pairs of ribs (HP:0000878)1.91754515
103Pelvic girdle muscle weakness (HP:0003749)1.91166797
104Acute myeloid leukemia (HP:0004808)1.90230568
105Abnormality of glycolysis (HP:0004366)1.89265257
106Pancreatic cysts (HP:0001737)1.87819818
107Morphological abnormality of the middle ear (HP:0008609)1.87201644
108Increased nuchal translucency (HP:0010880)1.86831437
109Abnormality of the prostate (HP:0008775)1.86515850
110Abnormality of the pancreatic islet cells (HP:0006476)1.85907919
111Abnormality of endocrine pancreas physiology (HP:0012093)1.85907919
112Neoplasm of the small intestine (HP:0100833)1.84800775
113Limb-girdle muscle atrophy (HP:0003797)1.84792110
114Sloping forehead (HP:0000340)1.84631383
115Neoplasm of the adrenal gland (HP:0100631)1.83979007
116Tented upper lip vermilion (HP:0010804)1.83689783
117Abnormal lung lobation (HP:0002101)1.81635419
118Elfin facies (HP:0004428)1.81161096
119Embryonal neoplasm (HP:0002898)1.80302607
120Chronic sinusitis (HP:0011109)1.79781443
121Insidious onset (HP:0003587)1.79566091
122Termporal pattern (HP:0011008)1.79566091
123Impaired vibration sensation in the lower limbs (HP:0002166)1.79365885
124Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79234511
125Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79234511
126Abnormality of serine family amino acid metabolism (HP:0010894)1.78364757
127Abnormality of glycine metabolism (HP:0010895)1.78364757
128Optic nerve coloboma (HP:0000588)1.77276827
129Ocular albinism (HP:0001107)1.77093861
130Progressive external ophthalmoplegia (HP:0000590)1.76717123
131Neuroendocrine neoplasm (HP:0100634)1.76521542
132Decreased circulating renin level (HP:0003351)1.75995760
133Abnormality of the columella (HP:0009929)1.74936444
134Hyperglycinemia (HP:0002154)1.73703867
135Central scotoma (HP:0000603)1.72002428
136Cafe-au-lait spot (HP:0000957)1.71826247
137Renal cortical cysts (HP:0000803)1.71792402
138Elevated erythrocyte sedimentation rate (HP:0003565)1.70049716
139Ectopic kidney (HP:0000086)1.69922868
140Molar tooth sign on MRI (HP:0002419)1.69717272
141Abnormality of midbrain morphology (HP:0002418)1.69717272
142Abnormal number of erythroid precursors (HP:0012131)1.68676234
143Hypoplasia of the thymus (HP:0000778)1.67710501
144Asplenia (HP:0001746)1.67572402
145Rhabdomyolysis (HP:0003201)1.65711800
146Flat cornea (HP:0007720)1.65646423
147Amaurosis fugax (HP:0100576)1.65229367
148Albinism (HP:0001022)1.65157048
149Postaxial foot polydactyly (HP:0001830)1.64488805
150Aplasia/Hypoplasia of the fovea (HP:0008060)1.64311579
151Hypoplasia of the fovea (HP:0007750)1.64311579
152Excessive salivation (HP:0003781)1.63661520
153Cystic hygroma (HP:0000476)1.63032643
154Gout (HP:0001997)1.62225369
155Congenital stationary night blindness (HP:0007642)1.60538476
156Neoplasm of the peripheral nervous system (HP:0100007)1.60286965
157Overlapping toe (HP:0001845)1.59974322
158Nonprogressive disorder (HP:0003680)1.59888327
159Broad-based gait (HP:0002136)1.59446572
160EMG: myopathic abnormalities (HP:0003458)1.59347215
161Acanthocytosis (HP:0001927)1.58722251
162Neoplasm of the colon (HP:0100273)1.58717149
163Abnormal respiratory epithelium morphology (HP:0012253)1.58582103
164Gonadotropin excess (HP:0000837)1.58177811
165Limb hypertonia (HP:0002509)1.57524050
166Hypoglycemic coma (HP:0001325)1.56645387
167Abnormality of methionine metabolism (HP:0010901)1.56312896
168Neoplasm of the thyroid gland (HP:0100031)1.55981151
169Lipid accumulation in hepatocytes (HP:0006561)1.54830018
170Enlarged kidneys (HP:0000105)1.53932041
171Abnormality of the calf musculature (HP:0001430)1.53465684
172Neuroblastic tumors (HP:0004376)1.52619341
173Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.52619341
174Neuroblastoma (HP:0003006)1.52619341
175Primitive neuroectodermal tumor (HP:0030065)1.52619341
176Distal arthrogryposis (HP:0005684)1.52582735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.01087343
2STK163.56112023
3OBSCN3.14498974
4NEK12.90680544
5SCYL22.81825698
6TSSK62.76594679
7BUB12.75719896
8TTK2.44110854
9MKNK22.32049226
10SIK32.13872818
11PBK2.11889088
12EIF2AK12.07921190
13MKNK12.07828881
14IRAK42.06631516
15CASK2.05915112
16INSRR1.96771251
17CDK191.96047913
18MUSK1.94285675
19ZAK1.90861088
20MAP2K71.90781227
21KIT1.87290338
22TEC1.86327681
23VRK11.83756716
24TLK11.82156020
25NTRK31.81611163
26PLK41.77922271
27CAMKK21.74663006
28FLT31.71317817
29PNCK1.70501428
30PASK1.69937285
31NUAK11.64810043
32LATS11.59053080
33BRD41.55404276
34PLK11.54652961
35IRAK31.52829276
36PLK31.52616156
37TRIM281.51469416
38YES11.45070465
39MAP3K121.44727149
40TGFBR11.43853628
41TNK21.41033224
42BMPR1B1.35915656
43BTK1.34918402
44ACVR1B1.34479554
45PHKG21.34472094
46PHKG11.34472094
47IRAK21.32831124
48ERBB31.31210012
49MAPK131.31003588
50SRPK11.29951832
51IRAK11.29063109
52TXK1.28904373
53MAP2K61.28357957
54ATR1.23154699
55DYRK31.21691619
56STK391.19713925
57RPS6KA41.19654529
58SIK21.14576020
59PINK11.09294964
60NEK21.05451089
61CAMK11.05007647
62CHEK11.04829055
63NLK1.01903378
64FES1.00849839
65EIF2AK20.98038651
66CCNB10.97264591
67CDK30.94781758
68AKT30.92277092
69MAP3K60.92117996
70MAP3K100.90357375
71TAOK20.89794783
72CDK80.89513028
73STK30.88137661
74GRK10.87580303
75CDC70.87251307
76ADRBK20.82425278
77MST40.82345107
78NEK60.81233269
79STK38L0.79082637
80MAP3K140.79026091
81BRSK20.77508729
82WEE10.77499524
83HIPK20.74004622
84NEK90.73304542
85WNK40.72497848
86CAMK1G0.71781025
87EIF2AK30.71525603
88MARK10.71159742
89CDK60.70121263
90SGK20.69732766
91CSNK1E0.67254114
92WNK30.66843809
93IKBKE0.66749268
94FGFR10.66688395
95BLK0.66263821
96TRPM70.66249415
97CDK120.66076985
98CSNK1G10.65462502
99CDK20.65085952
100CDK10.63825137
101CDK90.61410626
102ALK0.60991485
103OXSR10.60326640
104EEF2K0.59659126
105MAPKAPK50.58969034
106LYN0.58376412
107CDK70.56938117
108ERBB40.56870931
109MAP3K40.55499347
110MAP2K30.54474620
111BCKDK0.54323096
112FRK0.53965233
113DAPK10.53222438
114TIE10.53214723
115SGK30.51147228
116CSNK1G20.51104671
117SYK0.51059390
118ATM0.50597496
119TTN0.49479237
120PLK20.48963163
121CHEK20.48857866
122CLK10.47304587
123NTRK20.47039758
124CDK40.46777719
125CSF1R0.45115401
126AKT20.44082971
127MAPK150.43946935
128RPS6KA50.43839718
129CSNK1G30.41807504
130MATK0.41580258
131BCR0.41509849
132MAP4K20.40566114
133CSNK2A20.40213350
134RAF10.39985862
135PIK3CG0.39010389
136CAMK40.38984143
137UHMK10.38506640
138TGFBR20.38062989
139PRKACB0.36839259
140FGFR20.36794626
141CAMKK10.36731541
142CAMK1D0.36524683
143MAP3K130.35998632
144BRSK10.35634085
145JAK30.34197994
146AURKB0.34193362
147RPS6KB10.33827167
148PRKAA20.33065106
149CSNK1A1L0.31030850
150LCK0.29717525
151DYRK1A0.27959948
152MAP2K40.26138507
153NME20.25597505
154PRKDC0.25229246
155MAP4K10.24217000
156KSR10.23944752

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.21886934
2Mismatch repair_Homo sapiens_hsa034303.05781835
3DNA replication_Homo sapiens_hsa030302.96380348
4Homologous recombination_Homo sapiens_hsa034402.80768752
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.80763528
6Propanoate metabolism_Homo sapiens_hsa006402.68568380
7Non-homologous end-joining_Homo sapiens_hsa034502.54378495
8Ribosome_Homo sapiens_hsa030102.34008913
9Nicotine addiction_Homo sapiens_hsa050332.26622101
10Base excision repair_Homo sapiens_hsa034102.12754134
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.12489656
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04601059
13Pyruvate metabolism_Homo sapiens_hsa006201.91881812
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87124256
15Spliceosome_Homo sapiens_hsa030401.86894192
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76683337
17Transcriptional misregulation in cancer_Homo sapiens_hsa052021.74276908
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.73959421
19RNA degradation_Homo sapiens_hsa030181.73007857
20Primary immunodeficiency_Homo sapiens_hsa053401.72047153
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71812559
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69892914
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68835582
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68341533
25Nucleotide excision repair_Homo sapiens_hsa034201.65263646
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.58905822
27Carbon metabolism_Homo sapiens_hsa012001.58305003
28Selenocompound metabolism_Homo sapiens_hsa004501.56414353
29Biosynthesis of amino acids_Homo sapiens_hsa012301.45710292
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44254608
31Basal transcription factors_Homo sapiens_hsa030221.40801529
32Protein export_Homo sapiens_hsa030601.40415905
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39311972
34Alcoholism_Homo sapiens_hsa050341.37700807
35Taste transduction_Homo sapiens_hsa047421.37635416
36Systemic lupus erythematosus_Homo sapiens_hsa053221.37571959
37Pyrimidine metabolism_Homo sapiens_hsa002401.37458312
38Fatty acid metabolism_Homo sapiens_hsa012121.35094256
39Phototransduction_Homo sapiens_hsa047441.34631800
40Circadian entrainment_Homo sapiens_hsa047131.30109173
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28919836
42Morphine addiction_Homo sapiens_hsa050321.26153171
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.23908320
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22737560
45Vitamin B6 metabolism_Homo sapiens_hsa007501.22448703
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20974332
47Glutamatergic synapse_Homo sapiens_hsa047241.15666468
48Butanoate metabolism_Homo sapiens_hsa006501.15423750
49Purine metabolism_Homo sapiens_hsa002301.14706184
50Steroid biosynthesis_Homo sapiens_hsa001001.14584193
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13706141
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13339098
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12802897
54Cell cycle_Homo sapiens_hsa041101.11983187
55Herpes simplex infection_Homo sapiens_hsa051681.08370971
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.06763282
57Hematopoietic cell lineage_Homo sapiens_hsa046401.05962537
58SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04872049
59Oocyte meiosis_Homo sapiens_hsa041141.02736885
60Other glycan degradation_Homo sapiens_hsa005110.99738468
61Olfactory transduction_Homo sapiens_hsa047400.99298846
62RNA polymerase_Homo sapiens_hsa030200.99127307
63Circadian rhythm_Homo sapiens_hsa047100.97737155
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97661028
65mRNA surveillance pathway_Homo sapiens_hsa030150.97581348
66N-Glycan biosynthesis_Homo sapiens_hsa005100.97052524
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96965619
68Measles_Homo sapiens_hsa051620.92900599
69Fatty acid degradation_Homo sapiens_hsa000710.92794005
70Calcium signaling pathway_Homo sapiens_hsa040200.91882266
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87995654
72Thyroid cancer_Homo sapiens_hsa052160.87230042
73Serotonergic synapse_Homo sapiens_hsa047260.86928719
74Fatty acid elongation_Homo sapiens_hsa000620.85499595
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83960094
76Proteasome_Homo sapiens_hsa030500.82851135
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.80901295
78Amphetamine addiction_Homo sapiens_hsa050310.80159538
79Arginine and proline metabolism_Homo sapiens_hsa003300.77528955
80Allograft rejection_Homo sapiens_hsa053300.76330292
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75879480
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74650778
83Insulin secretion_Homo sapiens_hsa049110.73502654
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73194498
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70940401
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70077235
87Cocaine addiction_Homo sapiens_hsa050300.68120908
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67846100
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65707050
90beta-Alanine metabolism_Homo sapiens_hsa004100.63049503
91Adherens junction_Homo sapiens_hsa045200.62463384
92B cell receptor signaling pathway_Homo sapiens_hsa046620.61402166
93Glucagon signaling pathway_Homo sapiens_hsa049220.61258455
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59082145
95Sphingolipid metabolism_Homo sapiens_hsa006000.58956301
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.58766095
97Basal cell carcinoma_Homo sapiens_hsa052170.58672777
98cAMP signaling pathway_Homo sapiens_hsa040240.58046868
99ABC transporters_Homo sapiens_hsa020100.58007744
100Sulfur relay system_Homo sapiens_hsa041220.57991143
101Fatty acid biosynthesis_Homo sapiens_hsa000610.57422530
102Wnt signaling pathway_Homo sapiens_hsa043100.57075053
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56921847
104Autoimmune thyroid disease_Homo sapiens_hsa053200.54977211
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54571688
106GABAergic synapse_Homo sapiens_hsa047270.54296242
107Huntingtons disease_Homo sapiens_hsa050160.54010716
108Type I diabetes mellitus_Homo sapiens_hsa049400.53997381
109Lysine degradation_Homo sapiens_hsa003100.53833326
110Cholinergic synapse_Homo sapiens_hsa047250.52591156
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51740693
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51074251
113Platelet activation_Homo sapiens_hsa046110.50791732
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50439736
115Leishmaniasis_Homo sapiens_hsa051400.50273718
116AMPK signaling pathway_Homo sapiens_hsa041520.50184747
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49983124
118Long-term potentiation_Homo sapiens_hsa047200.47848172
119Colorectal cancer_Homo sapiens_hsa052100.47833125
120p53 signaling pathway_Homo sapiens_hsa041150.47331134
121Asthma_Homo sapiens_hsa053100.46842216
122Pentose phosphate pathway_Homo sapiens_hsa000300.45806687
123HTLV-I infection_Homo sapiens_hsa051660.45649882
124Dopaminergic synapse_Homo sapiens_hsa047280.45016488
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44845708
126Long-term depression_Homo sapiens_hsa047300.44532711
127Metabolic pathways_Homo sapiens_hsa011000.43003370
128Arginine biosynthesis_Homo sapiens_hsa002200.41224386
129Hepatitis B_Homo sapiens_hsa051610.40798739
130Inositol phosphate metabolism_Homo sapiens_hsa005620.40451260
131One carbon pool by folate_Homo sapiens_hsa006700.40327477
132Parkinsons disease_Homo sapiens_hsa050120.39894498
133Hippo signaling pathway_Homo sapiens_hsa043900.39233396
134RNA transport_Homo sapiens_hsa030130.38854746
135Melanogenesis_Homo sapiens_hsa049160.38342701
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37858714
137Influenza A_Homo sapiens_hsa051640.37807455
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37533265
139Insulin signaling pathway_Homo sapiens_hsa049100.37327971
140T cell receptor signaling pathway_Homo sapiens_hsa046600.37295439
141TGF-beta signaling pathway_Homo sapiens_hsa043500.35852824
142Choline metabolism in cancer_Homo sapiens_hsa052310.35583647
143Tryptophan metabolism_Homo sapiens_hsa003800.35402297
144Prolactin signaling pathway_Homo sapiens_hsa049170.34791378
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34710542
146Type II diabetes mellitus_Homo sapiens_hsa049300.33807080
147Peroxisome_Homo sapiens_hsa041460.33246863
148Oxytocin signaling pathway_Homo sapiens_hsa049210.33062548
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31874230
150MicroRNAs in cancer_Homo sapiens_hsa052060.31614513
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31462376
152Antigen processing and presentation_Homo sapiens_hsa046120.31383486
153Cardiac muscle contraction_Homo sapiens_hsa042600.30852403
154Tight junction_Homo sapiens_hsa045300.28945466
155Viral carcinogenesis_Homo sapiens_hsa052030.28442639
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28403389
157Endometrial cancer_Homo sapiens_hsa052130.28365760
158Prostate cancer_Homo sapiens_hsa052150.27370984
159Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26645783
160Central carbon metabolism in cancer_Homo sapiens_hsa052300.23021093
161Dilated cardiomyopathy_Homo sapiens_hsa054140.18194201
162Alzheimers disease_Homo sapiens_hsa050100.16084239
163Starch and sucrose metabolism_Homo sapiens_hsa005000.15987751
164Fructose and mannose metabolism_Homo sapiens_hsa000510.15160811
165Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.14849760
166Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13479107
167Oxidative phosphorylation_Homo sapiens_hsa001900.11849861

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