GUCY1B3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.00334102
2synaptic vesicle maturation (GO:0016188)5.80038617
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.73379846
4vocalization behavior (GO:0071625)5.65195891
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.55119930
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.51931062
7locomotory exploration behavior (GO:0035641)5.50955105
8synaptic vesicle exocytosis (GO:0016079)5.42244188
9glutamate secretion (GO:0014047)5.27286570
10regulation of glutamate receptor signaling pathway (GO:1900449)5.17526903
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16086017
12regulation of synaptic vesicle exocytosis (GO:2000300)5.10318153
13neurotransmitter-gated ion channel clustering (GO:0072578)4.95701307
14protein localization to synapse (GO:0035418)4.84477433
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.68982596
16neuron cell-cell adhesion (GO:0007158)4.56144549
17regulation of synapse structural plasticity (GO:0051823)4.47705097
18regulation of synaptic vesicle transport (GO:1902803)4.45949128
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.43333906
20neurotransmitter secretion (GO:0007269)4.42877767
21exploration behavior (GO:0035640)4.29810817
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.27915831
23regulation of neuronal synaptic plasticity (GO:0048168)4.18285003
24synaptic transmission, glutamatergic (GO:0035249)4.11519179
25neuron-neuron synaptic transmission (GO:0007270)4.09845350
26layer formation in cerebral cortex (GO:0021819)4.08115169
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02806466
28glutamate receptor signaling pathway (GO:0007215)4.00828907
29neuronal action potential propagation (GO:0019227)3.96982909
30positive regulation of synapse maturation (GO:0090129)3.91152813
31gamma-aminobutyric acid transport (GO:0015812)3.84742784
32regulation of excitatory postsynaptic membrane potential (GO:0060079)3.83207745
33auditory behavior (GO:0031223)3.80588035
34positive regulation of membrane potential (GO:0045838)3.79720224
35postsynaptic membrane organization (GO:0001941)3.76423932
36thrombin receptor signaling pathway (GO:0070493)3.74029993
37negative regulation of heart rate (GO:0010459)3.72347798
38long-term memory (GO:0007616)3.67815765
39dendritic spine morphogenesis (GO:0060997)3.65223302
40presynaptic membrane assembly (GO:0097105)3.64747728
41regulation of postsynaptic membrane potential (GO:0060078)3.63921832
42regulation of dendritic spine morphogenesis (GO:0061001)3.63782154
43relaxation of smooth muscle (GO:0044557)3.63549755
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63335516
45activation of protein kinase A activity (GO:0034199)3.62934955
46positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.62745643
47long-term synaptic potentiation (GO:0060291)3.58728576
48proline transport (GO:0015824)3.55016300
49regulation of synaptic plasticity (GO:0048167)3.54945085
50detection of calcium ion (GO:0005513)3.54064986
51positive regulation of neurotransmitter secretion (GO:0001956)3.52791731
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.52780709
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.48494390
54neurotransmitter transport (GO:0006836)3.47186242
55positive regulation of neurotransmitter transport (GO:0051590)3.46000424
56regulation of neurotransmitter secretion (GO:0046928)3.45774930
57negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45325729
58cellular potassium ion homeostasis (GO:0030007)3.42121935
59response to auditory stimulus (GO:0010996)3.39160245
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.37872372
61presynaptic membrane organization (GO:0097090)3.36891345
62neuron recognition (GO:0008038)3.35840724
63response to histamine (GO:0034776)3.35837712
64neuromuscular process controlling balance (GO:0050885)3.34887680
65mechanosensory behavior (GO:0007638)3.27331308
66regulation of neurotransmitter levels (GO:0001505)3.24267811
67G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.23269201
68regulation of neurotransmitter transport (GO:0051588)3.22740570
69negative regulation of neurotransmitter transport (GO:0051589)3.21824353
70transmission of nerve impulse (GO:0019226)3.20782316
71prepulse inhibition (GO:0060134)3.20687150
72positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.20575989
73cerebellar granule cell differentiation (GO:0021707)3.20298838
74regulation of platelet aggregation (GO:0090330)3.16996697
75synaptic vesicle endocytosis (GO:0048488)3.12834178
76regulation of dendritic spine development (GO:0060998)3.12449850
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11988593
78behavioral fear response (GO:0001662)3.11747565
79behavioral defense response (GO:0002209)3.11747565
80regulation of voltage-gated calcium channel activity (GO:1901385)3.11503952
81potassium ion import (GO:0010107)3.11300265
82regulation of synapse maturation (GO:0090128)3.09628408
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09392421
84positive regulation of synaptic transmission (GO:0050806)3.08350135
85relaxation of muscle (GO:0090075)3.08242004
86regulation of vesicle fusion (GO:0031338)3.07757668
87behavioral response to cocaine (GO:0048148)3.07196782
88membrane hyperpolarization (GO:0060081)3.07076678
89dendrite morphogenesis (GO:0048813)3.06341242
90regulation of female receptivity (GO:0045924)3.06018127
91cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05983526
92sleep (GO:0030431)3.05114394
93membrane depolarization (GO:0051899)3.04959859
94protein neddylation (GO:0045116)3.04942882
95axonal fasciculation (GO:0007413)3.04669110
96regulation of clathrin-mediated endocytosis (GO:2000369)3.04608546
97sodium ion export (GO:0071436)3.03502321
98negative regulation of response to food (GO:0032096)3.03277500
99negative regulation of appetite (GO:0032099)3.03277500
100vesicle docking involved in exocytosis (GO:0006904)3.02711590
101synapse assembly (GO:0007416)3.02321307
102female mating behavior (GO:0060180)3.01739418
103learning (GO:0007612)3.01092777
104megakaryocyte development (GO:0035855)3.00419904
105regulation of sensory perception of pain (GO:0051930)2.98334623
106regulation of sensory perception (GO:0051931)2.98334623
107cerebellar Purkinje cell differentiation (GO:0021702)2.97064317
108striatum development (GO:0021756)2.96634885
109regulation of cAMP-dependent protein kinase activity (GO:2000479)2.95915344
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94471108
111regulation of synaptic transmission (GO:0050804)2.93225030
112synaptic transmission (GO:0007268)2.92803840
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92766621
114fear response (GO:0042596)2.92512331
115vesicle transport along microtubule (GO:0047496)2.92324690
116cell communication by electrical coupling (GO:0010644)2.91911221
117aggressive behavior (GO:0002118)2.91905994
118membrane depolarization during action potential (GO:0086010)2.91382560
119negative regulation of heart contraction (GO:0045822)2.91346348
120neuromuscular process (GO:0050905)2.90741178
121negative regulation of dendrite morphogenesis (GO:0050774)2.90663927
122vesicle docking (GO:0048278)2.88844509
123regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88685445
124long term synaptic depression (GO:0060292)2.88042015
125regulation of glutamate secretion (GO:0014048)2.71706595
126neurotransmitter uptake (GO:0001504)2.71115064
127relaxation of cardiac muscle (GO:0055119)2.68830463
128negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.68383285
129negative regulation of calcium ion transmembrane transport (GO:1903170)2.68383285
130positive regulation of muscle hypertrophy (GO:0014742)2.65634789
131positive regulation of cardiac muscle hypertrophy (GO:0010613)2.65634789
132negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.64941841
133regulation of platelet activation (GO:0010543)2.64162308
134regulation of exocytosis (GO:0017157)2.63482838
135positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.62962713
136response to amphetamine (GO:0001975)2.61576461
137negative regulation of cation channel activity (GO:2001258)2.61042012
138nerve growth factor signaling pathway (GO:0038180)2.57030244
139serotonin metabolic process (GO:0042428)2.56033024
140regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.54271498
141monoamine transport (GO:0015844)2.53638305
142neuronal action potential (GO:0019228)2.51296313
143positive regulation of amino acid transport (GO:0051957)2.50992547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.32923719
2GBX2_23144817_ChIP-Seq_PC3_Human3.79830975
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19777626
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11366051
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99018734
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.71634851
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69325031
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69325031
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62747601
10REST_21632747_ChIP-Seq_MESCs_Mouse2.62741625
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60163607
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54651438
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54412711
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51330703
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50851601
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.50376167
17DROSHA_22980978_ChIP-Seq_HELA_Human2.50120505
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.24713635
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24170814
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.21580155
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.18636303
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16515375
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.15902277
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08972427
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01042112
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97271722
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97099529
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95805947
29AR_21572438_ChIP-Seq_LNCaP_Human1.91997624
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86849062
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.86780591
32IGF1R_20145208_ChIP-Seq_DFB_Human1.84681750
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84279017
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82092611
35TAF15_26573619_Chip-Seq_HEK293_Human1.80020158
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71709028
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67603395
38SMAD4_21799915_ChIP-Seq_A2780_Human1.67221084
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66192902
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62535813
41SCL_19346495_ChIP-Seq_HPC-7_Human1.50398809
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.48819923
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.48036338
44* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46775467
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45276952
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42931949
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42441604
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40898301
49P300_19829295_ChIP-Seq_ESCs_Human1.40020903
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.40019327
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38559111
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36709722
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.35744696
54* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33774206
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31356722
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30601608
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30368519
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30368519
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.28374034
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28263889
61AR_25329375_ChIP-Seq_VCAP_Human1.27388335
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25717997
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25079710
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.23943412
65AR_19668381_ChIP-Seq_PC3_Human1.23335593
66STAT3_23295773_ChIP-Seq_U87_Human1.23064692
67P53_22387025_ChIP-Seq_ESCs_Mouse1.22896386
68EWS_26573619_Chip-Seq_HEK293_Human1.22361740
69ZNF274_21170338_ChIP-Seq_K562_Hela1.20950902
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20750063
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.20039998
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20039365
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.19545367
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18610791
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18411938
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18360186
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.18347744
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18269266
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17793896
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15965342
81VDR_22108803_ChIP-Seq_LS180_Human1.15666333
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15068784
83BCAT_22108803_ChIP-Seq_LS180_Human1.14699752
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.14290451
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13929981
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.13001100
87TCF4_23295773_ChIP-Seq_U87_Human1.10886264
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.09737902
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09705637
90CBP_20019798_ChIP-Seq_JUKART_Human1.08653073
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08653073
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07953209
93AHR_22903824_ChIP-Seq_MCF-7_Human1.07833315
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07124741
95HTT_18923047_ChIP-ChIP_STHdh_Human1.06698622
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.06534140
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06464598
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06462878
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06339967
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.06268226
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05121155
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04948223
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04638447
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03939026
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02461772
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02364739
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01892825
108* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01731025
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01390206
110RNF2_27304074_Chip-Seq_NSC_Mouse1.01272591
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.00863737
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00668659
113NANOG_19829295_ChIP-Seq_ESCs_Human1.00311381
114SOX2_19829295_ChIP-Seq_ESCs_Human1.00311381
115FUS_26573619_Chip-Seq_HEK293_Human0.99059061
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.98692928
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97001160
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.96590707
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96282636
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96010458
121RUNX2_22187159_ChIP-Seq_PCA_Human0.95898354
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.95624218
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94381710
124KDM2B_26808549_Chip-Seq_K562_Human0.94040546
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.93385565
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93032856
127TP53_16413492_ChIP-PET_HCT116_Human0.92043680
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90901173
129JUN_21703547_ChIP-Seq_K562_Human0.88876895
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.87832879
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87514044
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87201527
133RXR_22108803_ChIP-Seq_LS180_Human0.84977290
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84869580
135ER_23166858_ChIP-Seq_MCF-7_Human0.84344619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.52958695
2MP0003880_abnormal_central_pattern4.75788006
3MP0003635_abnormal_synaptic_transmissio4.24483045
4MP0004270_analgesia3.66388139
5MP0002822_catalepsy3.64773413
6MP0009745_abnormal_behavioral_response3.55699953
7MP0002063_abnormal_learning/memory/cond3.45555066
8* MP0005464_abnormal_platelet_physiology3.22774228
9MP0002064_seizures3.21028600
10MP0009046_muscle_twitch3.10685431
11MP0001968_abnormal_touch/_nociception2.95988468
12MP0002572_abnormal_emotion/affect_behav2.85140489
13MP0005423_abnormal_somatic_nervous2.62771539
14MP0001486_abnormal_startle_reflex2.62665167
15MP0002734_abnormal_mechanical_nocicepti2.53222845
16MP0002272_abnormal_nervous_system2.51085621
17MP0009780_abnormal_chondrocyte_physiolo2.34280911
18MP0002736_abnormal_nociception_after2.31697739
19MP0001501_abnormal_sleep_pattern2.26378493
20MP0008004_abnormal_stomach_pH2.24138800
21MP0001440_abnormal_grooming_behavior2.07613798
22MP0002067_abnormal_sensory_capabilities1.88644345
23MP0002735_abnormal_chemical_nociception1.87773789
24MP0008569_lethality_at_weaning1.84055296
25MP0002733_abnormal_thermal_nociception1.82393288
26MP0001970_abnormal_pain_threshold1.81904947
27MP0004924_abnormal_behavior1.81519707
28MP0005386_behavior/neurological_phenoty1.81519707
29MP0002909_abnormal_adrenal_gland1.76868717
30MP0004811_abnormal_neuron_physiology1.74246437
31MP0003879_abnormal_hair_cell1.73186568
32MP0005646_abnormal_pituitary_gland1.72385173
33MP0002557_abnormal_social/conspecific_i1.72118371
34MP0003329_amyloid_beta_deposits1.70541257
35MP0000778_abnormal_nervous_system1.69997384
36MP0008877_abnormal_DNA_methylation1.69641185
37MP0002184_abnormal_innervation1.65942748
38MP0003787_abnormal_imprinting1.61147609
39MP0003724_increased_susceptibility_to1.57335791
40MP0001984_abnormal_olfaction1.53915156
41MP0004858_abnormal_nervous_system1.50954394
42MP0002138_abnormal_hepatobiliary_system1.45495683
43MP0000955_abnormal_spinal_cord1.42352238
44MP0001529_abnormal_vocalization1.41850739
45MP0004885_abnormal_endolymph1.39027987
46MP0002066_abnormal_motor_capabilities/c1.38463023
47MP0003633_abnormal_nervous_system1.36414729
48MP0002882_abnormal_neuron_morphology1.35122770
49* MP0000230_abnormal_systemic_arterial1.35017004
50MP0000751_myopathy1.31175440
51MP0003122_maternal_imprinting1.29111256
52MP0004147_increased_porphyrin_level1.27076603
53MP0001502_abnormal_circadian_rhythm1.23250038
54MP0001188_hyperpigmentation1.22653700
55MP0006276_abnormal_autonomic_nervous1.19357699
56MP0003195_calcinosis1.19065633
57MP0000465_gastrointestinal_hemorrhage1.17240816
58MP0000013_abnormal_adipose_tissue1.16354086
59MP0004085_abnormal_heartbeat1.14038714
60MP0002638_abnormal_pupillary_reflex1.13946420
61MP0001905_abnormal_dopamine_level1.13070152
62MP0003631_nervous_system_phenotype1.12036266
63MP0005551_abnormal_eye_electrophysiolog1.11204780
64MP0002837_dystrophic_cardiac_calcinosis1.10636386
65MP0004142_abnormal_muscle_tone1.09536406
66MP0003045_fibrosis1.09324454
67MP0005645_abnormal_hypothalamus_physiol1.05188343
68MP0004215_abnormal_myocardial_fiber1.05151622
69MP0002152_abnormal_brain_morphology1.04866324
70MP0008872_abnormal_physiological_respon1.01815076
71MP0001177_atelectasis1.01324209
72MP0008874_decreased_physiological_sensi0.98713019
73MP0004084_abnormal_cardiac_muscle0.97401177
74MP0003172_abnormal_lysosome_physiology0.95063970
75MP0002069_abnormal_eating/drinking_beha0.94003723
76MP0008775_abnormal_heart_ventricle0.90697213
77MP0005167_abnormal_blood-brain_barrier0.89913455
78MP0004233_abnormal_muscle_weight0.89815535
79MP0004145_abnormal_muscle_electrophysio0.89631348
80MP0002229_neurodegeneration0.88978112
81MP0001986_abnormal_taste_sensitivity0.88748403
82MP0004484_altered_response_of0.88260614
83MP0003075_altered_response_to0.87926256
84MP0002090_abnormal_vision0.87384697
85* MP0005084_abnormal_gallbladder_morpholo0.87032233
86MP0010386_abnormal_urinary_bladder0.84755790
87MP0008961_abnormal_basal_metabolism0.84429440
88MP0003252_abnormal_bile_duct0.84157365
89MP0002928_abnormal_bile_duct0.82395206
90MP0003137_abnormal_impulse_conducting0.82133409
91MP0005410_abnormal_fertilization0.80562047
92MP0003690_abnormal_glial_cell0.77534696
93MP0005535_abnormal_body_temperature0.77307863
94MP0002693_abnormal_pancreas_physiology0.77127474
95MP0000569_abnormal_digit_pigmentation0.77052067
96MP0003634_abnormal_glial_cell0.76441162
97MP0005623_abnormal_meninges_morphology0.75683199
98MP0004130_abnormal_muscle_cell0.73093010
99MP0001765_abnormal_ion_homeostasis0.72890040
100MP0001963_abnormal_hearing_physiology0.72767259
101MP0004742_abnormal_vestibular_system0.72540348
102MP0003632_abnormal_nervous_system0.70594100
103MP0000631_abnormal_neuroendocrine_gland0.69766259
104MP0003638_abnormal_response/metabolism_0.69696873
105MP0000604_amyloidosis0.69247427
106MP0002752_abnormal_somatic_nervous0.67851262
107MP0004036_abnormal_muscle_relaxation0.67803903
108MP0005174_abnormal_tail_pigmentation0.66585076
109MP0001756_abnormal_urination0.66463618
110MP0004043_abnormal_pH_regulation0.65952514
111MP0005620_abnormal_muscle_contractility0.65206682
112MP0003121_genomic_imprinting0.65042407
113MP0010329_abnormal_lipoprotein_level0.64654577
114MP0002876_abnormal_thyroid_physiology0.64285035
115MP0005394_taste/olfaction_phenotype0.64155788
116MP0005499_abnormal_olfactory_system0.64155788
117MP0000920_abnormal_myelination0.64127193
118MP0003646_muscle_fatigue0.61684067
119MP0001485_abnormal_pinna_reflex0.61390797
120MP0005409_darkened_coat_color0.59743191
121MP0003283_abnormal_digestive_organ0.58553116
122MP0001943_abnormal_respiration0.58259193
123* MP0001664_abnormal_digestion0.53382822
124MP0004510_myositis0.52995430
125* MP0010769_abnormal_survival0.51286568
126MP0005187_abnormal_penis_morphology0.50655226
127* MP0010770_preweaning_lethality0.50342587

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.88817710
2Myokymia (HP:0002411)6.79877641
3Prolonged bleeding time (HP:0003010)5.74822771
4Focal seizures (HP:0007359)5.68861793
5Epileptic encephalopathy (HP:0200134)5.49692551
6Visual hallucinations (HP:0002367)4.88091087
7Atonic seizures (HP:0010819)4.61272679
8Increased mean platelet volume (HP:0011877)4.48660857
9Petechiae (HP:0000967)4.44858877
10Febrile seizures (HP:0002373)4.33536037
11Absence seizures (HP:0002121)4.13254909
12Abnormal platelet volume (HP:0011876)4.06301828
13Menorrhagia (HP:0000132)4.05489788
14Hyperventilation (HP:0002883)3.90630810
15Progressive cerebellar ataxia (HP:0002073)3.88517910
16Broad-based gait (HP:0002136)3.85228758
17Dialeptic seizures (HP:0011146)3.78532099
18Generalized tonic-clonic seizures (HP:0002069)3.75770650
19Purpura (HP:0000979)3.66707839
20Poor eye contact (HP:0000817)3.61471035
21Action tremor (HP:0002345)3.48370928
22Ankle clonus (HP:0011448)3.30086921
23Impaired vibration sensation in the lower limbs (HP:0002166)3.27809483
24Impaired social interactions (HP:0000735)3.27631761
25Abnormal social behavior (HP:0012433)3.27631761
26Depression (HP:0000716)3.26343725
27Dysdiadochokinesis (HP:0002075)3.19722071
28Gaze-evoked nystagmus (HP:0000640)3.18896181
29Epistaxis (HP:0000421)3.17577694
30Abnormal eating behavior (HP:0100738)3.12167279
31Anxiety (HP:0000739)3.03975499
32Urinary bladder sphincter dysfunction (HP:0002839)3.03962236
33Supranuclear gaze palsy (HP:0000605)3.03322956
34Torticollis (HP:0000473)2.96990562
35Mutism (HP:0002300)2.95695666
36Amblyopia (HP:0000646)2.90613915
37Gingival bleeding (HP:0000225)2.86359800
38Dysmetria (HP:0001310)2.85489527
39Papilledema (HP:0001085)2.84343465
40Truncal ataxia (HP:0002078)2.80326160
41Drooling (HP:0002307)2.80099304
42Excessive salivation (HP:0003781)2.80099304
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.78188388
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.78188388
45Postural instability (HP:0002172)2.77595307
46Abnormality of the lower motor neuron (HP:0002366)2.76614785
47Dysmetric saccades (HP:0000641)2.69668349
48Focal dystonia (HP:0004373)2.68501492
49Urinary urgency (HP:0000012)2.66208393
50Epileptiform EEG discharges (HP:0011182)2.62682638
51Stereotypic behavior (HP:0000733)2.58187994
52Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.56613439
53Genetic anticipation (HP:0003743)2.56005888
54Progressive inability to walk (HP:0002505)2.55276451
55Annular pancreas (HP:0001734)2.54213588
56Scanning speech (HP:0002168)2.53994981
57Abnormality of binocular vision (HP:0011514)2.47617547
58Diplopia (HP:0000651)2.47617547
59Impaired smooth pursuit (HP:0007772)2.46538844
60Hemiparesis (HP:0001269)2.46324881
61Abnormal platelet function (HP:0011869)2.46286369
62Impaired platelet aggregation (HP:0003540)2.46286369
63Craniofacial dystonia (HP:0012179)2.45055022
64EEG with generalized epileptiform discharges (HP:0011198)2.44035865
65Hyperlipoproteinemia (HP:0010980)2.43898342
66Pheochromocytoma (HP:0002666)2.42395475
67Spastic gait (HP:0002064)2.42315006
68Insidious onset (HP:0003587)2.42042007
69Termporal pattern (HP:0011008)2.42042007
70Polyphagia (HP:0002591)2.39755156
71Hypothermia (HP:0002045)2.39368173
72Bradykinesia (HP:0002067)2.36446970
73Hemiplegia (HP:0002301)2.34287538
74Inability to walk (HP:0002540)2.33909498
75Limb dystonia (HP:0002451)2.33597803
76Hypsarrhythmia (HP:0002521)2.32001356
77Impaired vibratory sensation (HP:0002495)2.31526967
78Resting tremor (HP:0002322)2.31300047
79Abnormality of the corticospinal tract (HP:0002492)2.29003391
80Neurofibrillary tangles (HP:0002185)2.28836035
81Ketoacidosis (HP:0001993)2.27585900
82Cerebral inclusion bodies (HP:0100314)2.26561414
83Intention tremor (HP:0002080)2.23749857
84Status epilepticus (HP:0002133)2.22480849
85Increased circulating renin level (HP:0000848)2.21299996
86Absent speech (HP:0001344)2.20908022
87Megalencephaly (HP:0001355)2.19656930
88Fetal akinesia sequence (HP:0001989)2.17090996
89Hypomagnesemia (HP:0002917)2.16976396
90Lower limb muscle weakness (HP:0007340)2.14883701
91Ventricular fibrillation (HP:0001663)2.12085207
92Abnormal drinking behavior (HP:0030082)2.11545189
93Polydipsia (HP:0001959)2.11545189
94Abnormality of ocular smooth pursuit (HP:0000617)2.10992880
95Incomplete penetrance (HP:0003829)2.09375765
96Tetraplegia (HP:0002445)2.08661084
97Amyotrophic lateral sclerosis (HP:0007354)2.06423719
98Generalized myoclonic seizures (HP:0002123)2.05827370
99Blue irides (HP:0000635)2.04597558
100Pointed chin (HP:0000307)2.03849752
101Lower limb amyotrophy (HP:0007210)2.03315093
102Neuroendocrine neoplasm (HP:0100634)2.02729949
103Delusions (HP:0000746)1.95941142
104Morphological abnormality of the pyramidal tract (HP:0002062)1.95559642
105Abnormal EKG (HP:0003115)1.94037558
106Decreased central vision (HP:0007663)1.93396384
107Hyperthyroidism (HP:0000836)1.92619210
108Protruding tongue (HP:0010808)1.92591925
109Gait ataxia (HP:0002066)1.89659493
110Prolonged QT interval (HP:0001657)1.88812879
111Obstructive sleep apnea (HP:0002870)1.87134570
112Hypoventilation (HP:0002791)1.86440330
113Failure to thrive in infancy (HP:0001531)1.84863066
114Gait imbalance (HP:0002141)1.84615410
115Intellectual disability, profound (HP:0002187)1.83626450
116Ankyloglossia (HP:0010296)1.83278703
117Central scotoma (HP:0000603)1.82671798
118Abnormality of calcium-phosphate metabolism (HP:0100530)1.82221747
119Abnormality of salivation (HP:0100755)1.81340484
120Spastic tetraparesis (HP:0001285)1.80584062
121Agitation (HP:0000713)1.80077218
122Medial flaring of the eyebrow (HP:0010747)1.80013933
123Hypoglycemic seizures (HP:0002173)1.79142654
124Hypoglycemic coma (HP:0001325)1.78844553
125Clonus (HP:0002169)1.77670155
126Bundle branch block (HP:0011710)1.77416079
127Specific learning disability (HP:0001328)1.76477826
128Inappropriate behavior (HP:0000719)1.76269466
129Neoplasm of the peripheral nervous system (HP:0100007)1.75205337
130Hyperphosphatemia (HP:0002905)1.74905616
131Muscular hypotonia of the trunk (HP:0008936)1.73597296
132Akinesia (HP:0002304)1.72654938
133Thickened helices (HP:0000391)1.72603188
134Abnormality of saccadic eye movements (HP:0000570)1.71788663
135Poikilocytosis (HP:0004447)1.71657346
136Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71316232
137Sudden death (HP:0001699)1.70519354
138Widely spaced teeth (HP:0000687)1.67636993
139Papillary thyroid carcinoma (HP:0002895)1.64130977
140Syncope (HP:0001279)1.63462573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.67839551
2NTRK33.97822503
3MAP4K23.65062488
4MAP3K93.58487157
5MARK13.44992758
6DAPK23.01815192
7CASK3.00311724
8MAP3K42.98322395
9FRK2.75863595
10MAP2K72.58669682
11MINK12.48999249
12PAK62.18609806
13KSR22.04094662
14NTRK21.96224384
15CAMKK11.85659877
16MAP3K121.82875008
17DAPK11.82404728
18MAP2K41.81889032
19PRKD31.73036340
20CDK191.64234682
21KSR11.62268317
22PRPF4B1.61080706
23PLK21.57377642
24NTRK11.55981098
25CDK51.54326466
26TAOK31.40529917
27TEC1.36366818
28CCNB11.29893709
29TNIK1.28998543
30RIPK41.27955932
31MAPK131.26465928
32MST41.25567652
33CAMKK21.17306510
34GRK51.16825691
35STK381.16660529
36PHKG21.15941106
37PHKG11.15941106
38PRKCG1.14855805
39TAOK11.14281607
40MYLK1.13721962
41FES1.09087918
42MAP3K21.08106686
43ARAF1.06786494
44SIK21.04592876
45ADRBK21.02611713
46FGFR21.01638983
47TYRO30.98397947
48CAMK2A0.97712434
49SGK4940.96047827
50SGK2230.96047827
51OXSR10.95314052
52CDK180.94625230
53CAMK10.92443926
54CDK150.91838569
55MAP3K130.91104188
56NEK10.90980087
57SYK0.90725821
58PTK2B0.90145461
59GRK10.89946608
60CDK140.88978068
61UHMK10.88706006
62LATS20.87317271
63AKT30.86725939
64MAPKAPK30.86159401
65STK110.85452627
66PRKCH0.85275383
67SGK20.84962508
68CSNK1G30.82872812
69RAF10.80073413
70BMX0.80007900
71CDK11A0.78733966
72RET0.76529125
73CAMK2B0.76165253
74NUAK10.74792307
75MARK20.74379691
76SGK30.73496366
77PNCK0.73177532
78PAK30.72353367
79BMPR1B0.71168297
80SGK10.69791089
81CSNK1G10.68627142
82PINK10.65777232
83DAPK30.64619038
84PRKG10.63040869
85CSNK1G20.62646839
86PDK10.61111945
87BCR0.60657236
88INSRR0.60652463
89DYRK1A0.60403679
90LMTK20.59705908
91PDPK10.59681260
92IRAK20.58232510
93PRKCE0.57689282
94ALK0.57112900
95TRPM70.56271941
96PDK40.55267046
97PDK30.55267046
98ADRBK10.54452317
99TRIM280.53059501
100PRKG20.51764696
101DMPK0.50971217
102MAPK120.50871073
103MAP3K10.50867229
104PRKCZ0.50751645
105BMPR20.50342527
106MAP2K60.49337165
107STK390.49024301
108FER0.48602784
109MAPKAPK50.48480727
110RPS6KA30.47893673
111PRKCA0.47588464
112FYN0.47355603
113CAMK40.47118256
114CDK30.46989656
115CDC42BPA0.45485111
116MAP2K10.45026285
117PRKCQ0.44056861
118RIPK10.44052276
119PRKACA0.43482056
120MAP3K70.40945619
121PRKCB0.40424732
122CAMK2D0.39227165
123CSF1R0.38837062
124PKN10.38706431
125NEK60.38535250
126PIK3CG0.38070174
127PRKACG0.37933058
128CAMK2G0.36689017
129MAP3K60.35876075
130SIK30.35468853
131TNK20.34033812
132MAPK100.33171249
133ERBB30.32675818
134RPS6KA20.31335731
135FGR0.30679375

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62064914
2Synaptic vesicle cycle_Homo sapiens_hsa047213.39465926
3Olfactory transduction_Homo sapiens_hsa047402.88253231
4GABAergic synapse_Homo sapiens_hsa047272.75029758
5* Circadian entrainment_Homo sapiens_hsa047132.68506612
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67446230
7Morphine addiction_Homo sapiens_hsa050322.63275933
8Long-term potentiation_Homo sapiens_hsa047202.55402161
9Glutamatergic synapse_Homo sapiens_hsa047242.47589696
10Amphetamine addiction_Homo sapiens_hsa050312.43155332
11Dopaminergic synapse_Homo sapiens_hsa047282.17268942
12* Salivary secretion_Homo sapiens_hsa049702.03189323
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00829548
14* Platelet activation_Homo sapiens_hsa046111.98806617
15Insulin secretion_Homo sapiens_hsa049111.94302789
16Cholinergic synapse_Homo sapiens_hsa047251.91899026
17Gastric acid secretion_Homo sapiens_hsa049711.82372360
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80265881
19* Renin secretion_Homo sapiens_hsa049241.77038039
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71186478
21Cocaine addiction_Homo sapiens_hsa050301.68129114
22* Oxytocin signaling pathway_Homo sapiens_hsa049211.67357748
23Collecting duct acid secretion_Homo sapiens_hsa049661.65596022
24Taste transduction_Homo sapiens_hsa047421.61434021
25Calcium signaling pathway_Homo sapiens_hsa040201.60771165
26Serotonergic synapse_Homo sapiens_hsa047261.59231039
27* Long-term depression_Homo sapiens_hsa047301.50566828
28GnRH signaling pathway_Homo sapiens_hsa049121.36514582
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33936765
30* Gap junction_Homo sapiens_hsa045401.32946121
31cAMP signaling pathway_Homo sapiens_hsa040241.29994902
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27163390
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24219588
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.18660949
35Axon guidance_Homo sapiens_hsa043601.14380788
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10937897
37Type II diabetes mellitus_Homo sapiens_hsa049301.10630056
38Estrogen signaling pathway_Homo sapiens_hsa049151.09297069
39Glioma_Homo sapiens_hsa052141.09176903
40* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08079380
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07431729
42Vibrio cholerae infection_Homo sapiens_hsa051101.04019711
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02494176
44Phototransduction_Homo sapiens_hsa047441.01428519
45Dilated cardiomyopathy_Homo sapiens_hsa054140.99184974
46Cardiac muscle contraction_Homo sapiens_hsa042600.99002568
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98716066
48ErbB signaling pathway_Homo sapiens_hsa040120.97159962
49Melanogenesis_Homo sapiens_hsa049160.96984840
50* Vascular smooth muscle contraction_Homo sapiens_hsa042700.96388638
51Nitrogen metabolism_Homo sapiens_hsa009100.83598061
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82397697
53Oocyte meiosis_Homo sapiens_hsa041140.80617789
54Dorso-ventral axis formation_Homo sapiens_hsa043200.78639334
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78387736
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76932502
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.76699878
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76177870
59Arachidonic acid metabolism_Homo sapiens_hsa005900.74863346
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74794216
61Regulation of autophagy_Homo sapiens_hsa041400.73841804
62Pancreatic secretion_Homo sapiens_hsa049720.71641376
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71424780
64Fatty acid elongation_Homo sapiens_hsa000620.71128521
65beta-Alanine metabolism_Homo sapiens_hsa004100.70190112
66MAPK signaling pathway_Homo sapiens_hsa040100.69514081
67Thyroid hormone synthesis_Homo sapiens_hsa049180.67005583
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64505106
69Asthma_Homo sapiens_hsa053100.63840792
70Glucagon signaling pathway_Homo sapiens_hsa049220.61416380
71Choline metabolism in cancer_Homo sapiens_hsa052310.60866272
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60641037
73Ras signaling pathway_Homo sapiens_hsa040140.60186952
74Rap1 signaling pathway_Homo sapiens_hsa040150.59208052
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59135235
76ABC transporters_Homo sapiens_hsa020100.56995396
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56655581
78Rheumatoid arthritis_Homo sapiens_hsa053230.54692916
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54261101
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.54014908
81VEGF signaling pathway_Homo sapiens_hsa043700.52228097
82Circadian rhythm_Homo sapiens_hsa047100.51151674
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50961771
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50181211
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50109621
86Alcoholism_Homo sapiens_hsa050340.50021703
87Bile secretion_Homo sapiens_hsa049760.49613935
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49338515
89mTOR signaling pathway_Homo sapiens_hsa041500.49101814
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47541153
91Renal cell carcinoma_Homo sapiens_hsa052110.47015994
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46209180
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45638545
94Endometrial cancer_Homo sapiens_hsa052130.45386695
95Glycerolipid metabolism_Homo sapiens_hsa005610.44931975
96Endocytosis_Homo sapiens_hsa041440.44710241
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.43983798
98Type I diabetes mellitus_Homo sapiens_hsa049400.43912428
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43336140
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42469731
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41956470
102Linoleic acid metabolism_Homo sapiens_hsa005910.41863636
103Insulin signaling pathway_Homo sapiens_hsa049100.41534251
104Inositol phosphate metabolism_Homo sapiens_hsa005620.41030958
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.40701625
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40636670
107Prion diseases_Homo sapiens_hsa050200.40546572
108Ovarian steroidogenesis_Homo sapiens_hsa049130.37583413
109Non-small cell lung cancer_Homo sapiens_hsa052230.37106200
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.35939093
111Ether lipid metabolism_Homo sapiens_hsa005650.35875644
112Tryptophan metabolism_Homo sapiens_hsa003800.35470203
113ECM-receptor interaction_Homo sapiens_hsa045120.35415949
114Wnt signaling pathway_Homo sapiens_hsa043100.35193404
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33703617
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33119466
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.32465175
118Peroxisome_Homo sapiens_hsa041460.32330736
119Chemokine signaling pathway_Homo sapiens_hsa040620.31514559
120Butanoate metabolism_Homo sapiens_hsa006500.30732012
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30556285
122Alzheimers disease_Homo sapiens_hsa050100.29027222
123African trypanosomiasis_Homo sapiens_hsa051430.28229748

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