GUCY1A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)7.20395867
2regulation of female receptivity (GO:0045924)7.08560186
3female mating behavior (GO:0060180)6.08731630
4sodium ion export (GO:0071436)5.74991207
5synaptic vesicle exocytosis (GO:0016079)5.53485879
6synaptic vesicle maturation (GO:0016188)5.40139972
7detection of light stimulus involved in visual perception (GO:0050908)5.39377635
8detection of light stimulus involved in sensory perception (GO:0050962)5.39377635
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34971108
10G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.16770065
11aggressive behavior (GO:0002118)5.15868559
12cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.04335341
13cellular potassium ion homeostasis (GO:0030007)4.97522471
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.89048935
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.67763901
16regulation of synaptic vesicle exocytosis (GO:2000300)4.67635643
17definitive hemopoiesis (GO:0060216)4.62216266
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.59554984
19regulation of synapse structural plasticity (GO:0051823)4.58716650
20cell communication by electrical coupling (GO:0010644)4.56863843
21vocalization behavior (GO:0071625)4.55538814
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.53562625
23protein localization to synapse (GO:0035418)4.46099559
24positive regulation of synapse maturation (GO:0090129)4.43811085
25endothelium development (GO:0003158)4.38027516
26response to pheromone (GO:0019236)4.29854036
27thrombin receptor signaling pathway (GO:0070493)4.26163133
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.20689312
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.12681095
30potassium ion homeostasis (GO:0055075)4.09714992
31neurotransmitter-gated ion channel clustering (GO:0072578)4.08005367
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.06587464
33cellular sodium ion homeostasis (GO:0006883)4.05283364
34synaptic vesicle endocytosis (GO:0048488)3.99712608
35regulation of glutamate receptor signaling pathway (GO:1900449)3.95999345
36retinal rod cell development (GO:0046548)3.90573304
37regulation of synaptic vesicle transport (GO:1902803)3.89901053
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87554913
39neurotransmitter secretion (GO:0007269)3.87134271
40locomotory exploration behavior (GO:0035641)3.86724285
41glutamate receptor signaling pathway (GO:0007215)3.85619000
42glutamate secretion (GO:0014047)3.81390145
43prepulse inhibition (GO:0060134)3.80336629
44regulation of synapse maturation (GO:0090128)3.76616431
45positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.74794191
46layer formation in cerebral cortex (GO:0021819)3.73706753
47striatum development (GO:0021756)3.71315636
48positive regulation of vasculogenesis (GO:2001214)3.65417253
49neuron cell-cell adhesion (GO:0007158)3.59761421
50innervation (GO:0060384)3.58417966
51relaxation of cardiac muscle (GO:0055119)3.55165588
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.48552198
53membrane hyperpolarization (GO:0060081)3.47846909
54membrane depolarization during action potential (GO:0086010)3.45151154
55mating behavior (GO:0007617)3.42498298
56* relaxation of smooth muscle (GO:0044557)3.40416033
57regulation of neurotransmitter secretion (GO:0046928)3.37692778
58synapse assembly (GO:0007416)3.36474690
59neuron-neuron synaptic transmission (GO:0007270)3.34632828
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.34417782
61peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.34353538
62interkinetic nuclear migration (GO:0022027)3.31407592
63regulation of platelet aggregation (GO:0090330)3.30658815
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29588788
65regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.28035926
66exploration behavior (GO:0035640)3.27818160
67synaptic transmission, glutamatergic (GO:0035249)3.27483422
68regulation of neurotransmitter transport (GO:0051588)3.26564725
69seminiferous tubule development (GO:0072520)3.26129514
70ionotropic glutamate receptor signaling pathway (GO:0035235)3.25810987
71neurotransmitter transport (GO:0006836)3.22964097
72negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.22100730
73positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.21752765
74cell communication involved in cardiac conduction (GO:0086065)3.20278583
75calcium ion import (GO:0070509)3.19443395
76tachykinin receptor signaling pathway (GO:0007217)3.19414063
77regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.17690809
78dendrite morphogenesis (GO:0048813)3.15277302
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.14963605
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.13038963
81regulation of neuronal synaptic plasticity (GO:0048168)3.09643036
82cerebellar Purkinje cell differentiation (GO:0021702)3.09553936
83regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.09481310
84regulation of relaxation of muscle (GO:1901077)3.08605314
85substrate-independent telencephalic tangential migration (GO:0021826)3.07292529
86substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.07292529
87monoamine transport (GO:0015844)3.06892709
88regulation of long-term neuronal synaptic plasticity (GO:0048169)3.06832544
89regulation of inositol phosphate biosynthetic process (GO:0010919)3.06762336
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05731710
91cardiac myofibril assembly (GO:0055003)3.05588363
92positive regulation of granulocyte differentiation (GO:0030854)3.04873992
93multicellular organismal reproductive behavior (GO:0033057)3.04246880
94* relaxation of muscle (GO:0090075)3.02632956
95long-term synaptic potentiation (GO:0060291)3.02516610
96positive regulation of neurotransmitter transport (GO:0051590)3.00474495
97positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00300699
98myofibril assembly (GO:0030239)3.00210319
99adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.99780069
100regulation of platelet activation (GO:0010543)2.99519413
101behavioral response to ethanol (GO:0048149)2.99350048
102establishment of synaptic vesicle localization (GO:0097480)2.99117716
103synaptic vesicle transport (GO:0048489)2.99117716
104potassium ion import (GO:0010107)2.98616400
105long-term memory (GO:0007616)2.98602011
106megakaryocyte development (GO:0035855)2.97217548
107negative regulation of T cell receptor signaling pathway (GO:0050860)2.96690212
108regulation of dendritic spine morphogenesis (GO:0061001)2.96557355
109regulation of voltage-gated calcium channel activity (GO:1901385)2.95759414
110positive regulation of membrane potential (GO:0045838)2.95096643
111maternal behavior (GO:0042711)2.94474396
112activation of protein kinase A activity (GO:0034199)2.93270995
113positive regulation of potassium ion transmembrane transport (GO:1901381)2.92266417
114response to histamine (GO:0034776)2.91029675
115positive regulation of neurotransmitter secretion (GO:0001956)2.90771427
116long term synaptic depression (GO:0060292)2.90511886
117regulation of postsynaptic membrane potential (GO:0060078)2.89849419
118carnitine transmembrane transport (GO:1902603)2.89675842
119regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88736563
120dendritic spine morphogenesis (GO:0060997)2.88727221
121parental behavior (GO:0060746)2.88306301
122negative regulation of stress fiber assembly (GO:0051497)2.88234480
123urinary tract smooth muscle contraction (GO:0014848)2.87950726
124carnitine shuttle (GO:0006853)2.87839719
125negative regulation of heart rate (GO:0010459)2.87716086
126auditory behavior (GO:0031223)2.87502381
127negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.87209743
128behavioral response to cocaine (GO:0048148)2.86840042
129behavioral fear response (GO:0001662)2.85316447
130behavioral defense response (GO:0002209)2.85316447
131synaptic transmission, dopaminergic (GO:0001963)2.85166183
132positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.82475021
133regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.81005251
134regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.81005251
135regulation of vesicle fusion (GO:0031338)2.79618979
136cell migration in hindbrain (GO:0021535)2.78389983
137regulation of Golgi to plasma membrane protein transport (GO:0042996)2.77977728
138regulation of vasculogenesis (GO:2001212)2.77158954
139positive regulation of uterine smooth muscle contraction (GO:0070474)2.77043616
140histamine secretion (GO:0001821)2.76360307
141cardiolipin metabolic process (GO:0032048)2.75353389
142negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.75251250
143regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.72375668
144adrenergic receptor signaling pathway (GO:0071875)2.68179186
145positive regulation of digestive system process (GO:0060456)2.67854860
146angiogenesis involved in wound healing (GO:0060055)2.66754194
147negative regulation of actin filament bundle assembly (GO:0032232)2.66667469
148carnitine transport (GO:0015879)2.65483592
149amino-acid betaine transport (GO:0015838)2.65483592
150fatty acid transmembrane transport (GO:1902001)2.62387376
151blood coagulation, intrinsic pathway (GO:0007597)2.62337990
152bundle of His cell to Purkinje myocyte communication (GO:0086069)2.61373445
153positive regulation of B cell differentiation (GO:0045579)2.61216587
154cell differentiation involved in metanephros development (GO:0072202)2.59895252
155negative regulation of calcium ion transmembrane transport (GO:1903170)2.58992591
156negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.58992591
157epithelial cell differentiation involved in kidney development (GO:0035850)2.58990931
158positive regulation of phosphatase activity (GO:0010922)2.58791716
159phosphatidylinositol acyl-chain remodeling (GO:0036149)2.54049127
160autophagic vacuole fusion (GO:0000046)2.54005401
161xenobiotic catabolic process (GO:0042178)2.52514360
162regulation of skeletal muscle contraction (GO:0014819)2.50583773
163positive regulation of steroid hormone secretion (GO:2000833)2.50366585
164positive regulation of cation channel activity (GO:2001259)2.47563442
165regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.47338498
166cardiac muscle hypertrophy (GO:0003300)2.47054307
167phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.45491223
168purinergic nucleotide receptor signaling pathway (GO:0035590)2.43644574
169regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42911428
170glomerular filtration (GO:0003094)2.42830557
171histamine transport (GO:0051608)2.41424790
172regulation of memory T cell differentiation (GO:0043380)2.35365605
173neutrophil activation involved in immune response (GO:0002283)2.34872401
174striated muscle hypertrophy (GO:0014897)2.34503955
175regulation of T cell receptor signaling pathway (GO:0050856)2.32837783
176negative regulation of hormone metabolic process (GO:0032351)2.31526747
177positive regulation of protein homodimerization activity (GO:0090073)2.29865613
178negative regulation of platelet activation (GO:0010544)2.29594099
179regulation of lipoprotein metabolic process (GO:0050746)2.28059924
180negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.26998825
181negative regulation of T-helper cell differentiation (GO:0045623)2.26998825
182adenosine metabolic process (GO:0046085)2.25903086
183dopamine transport (GO:0015872)2.23195378
184quaternary ammonium group transport (GO:0015697)2.22562759
185regulation of uterine smooth muscle contraction (GO:0070472)2.19748048
186detection of calcium ion (GO:0005513)2.18413371
187muscle hypertrophy (GO:0014896)2.17909887
188positive regulation of vascular permeability (GO:0043117)2.17834202
189organelle membrane fusion (GO:0090174)2.17548236
190growth hormone receptor signaling pathway (GO:0060396)2.17408906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.09323701
2GBX2_23144817_ChIP-Seq_PC3_Human3.87467099
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09748121
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03583603
5SCL_19346495_ChIP-Seq_HPC-7_Human3.03123192
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.99536752
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.95251385
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88043438
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.75230144
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70631157
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.66445246
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63698678
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63698678
14DROSHA_22980978_ChIP-Seq_HELA_Human2.58123779
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55582893
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48580660
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47152801
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.45993225
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45874522
20REST_21632747_ChIP-Seq_MESCs_Mouse2.40412300
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37045246
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36827784
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31993671
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.31579672
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.27303337
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24047478
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16656713
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.15487866
29* RARB_27405468_Chip-Seq_BRAIN_Mouse2.12049954
30GATA1_22025678_ChIP-Seq_K562_Human2.08434507
31AR_21572438_ChIP-Seq_LNCaP_Human2.07881596
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93465385
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92963924
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.91868881
35* REST_18959480_ChIP-ChIP_MESCs_Mouse1.86023561
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.82671399
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80623689
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79284048
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77487522
40TAF15_26573619_Chip-Seq_HEK293_Human1.76379202
41VDR_22108803_ChIP-Seq_LS180_Human1.73127659
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72781176
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71782834
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71250156
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70828170
46SMAD4_21799915_ChIP-Seq_A2780_Human1.69576579
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67688009
48GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63119299
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.58733479
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58726204
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.58726204
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56241499
53P53_22127205_ChIP-Seq_FIBROBLAST_Human1.55086155
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54700438
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54165310
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53008801
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52651911
58ZNF274_21170338_ChIP-Seq_K562_Hela1.48453568
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47831693
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.47593892
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45867173
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45568364
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.38190606
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.37558093
65* P300_19829295_ChIP-Seq_ESCs_Human1.36833620
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.36494208
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35814260
68* EWS_26573619_Chip-Seq_HEK293_Human1.32437231
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.32082880
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28736454
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.28538134
72AR_25329375_ChIP-Seq_VCAP_Human1.27903390
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27178991
74* AR_19668381_ChIP-Seq_PC3_Human1.25526587
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23726801
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23642426
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.23043741
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.21195240
79RNF2_27304074_Chip-Seq_NSC_Mouse1.20930681
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19850902
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18958665
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18868096
83* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17794044
84HTT_18923047_ChIP-ChIP_STHdh_Human1.17546194
85* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16656124
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.15953019
87STAT3_23295773_ChIP-Seq_U87_Human1.15868060
88* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15817736
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14654055
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.14443188
91SOX2_19829295_ChIP-Seq_ESCs_Human1.14250550
92NANOG_19829295_ChIP-Seq_ESCs_Human1.14250550
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14117985
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12072204
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11762158
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11398004
97* FUS_26573619_Chip-Seq_HEK293_Human1.11359951
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10240823
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10224401
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10020943
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.09946002
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09005064
103* SMAD4_21741376_ChIP-Seq_HESCs_Human1.08880703
104TCF4_23295773_ChIP-Seq_U87_Human1.08760250
105GATA1_19941826_ChIP-Seq_K562_Human1.08535724
106* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06923594
107* TAL1_26923725_Chip-Seq_HPCs_Mouse1.06710331
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06507328
109IGF1R_20145208_ChIP-Seq_DFB_Human1.06408488
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.06135998
111BCAT_22108803_ChIP-Seq_LS180_Human1.06005226
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05924580
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05776105
114GATA2_19941826_ChIP-Seq_K562_Human1.05307123
115* E2F1_18555785_Chip-Seq_ESCs_Mouse1.04693806
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.04687754
117AHR_22903824_ChIP-Seq_MCF-7_Human1.04177131
118* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03680667
119EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03410101
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02591719
121CDX2_22108803_ChIP-Seq_LS180_Human1.02485974
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.02479887
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01855483
124P53_22387025_ChIP-Seq_ESCs_Mouse1.01331036
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01279827
126* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00839275
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00644660
128DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00614833
129* EP300_21415370_ChIP-Seq_HL-1_Mouse1.00454243
130RUNX_20019798_ChIP-Seq_JUKART_Human1.00403583
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00181447
132FOXA1_25552417_ChIP-Seq_VCAP_Human0.99991500
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98127543
134VDR_24787735_ChIP-Seq_THP-1_Human0.97472369
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96942431
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96488015
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96325635
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95737461
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.95497588
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92901587
141FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92643465
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92510429
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92510429
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91887998
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91706579
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.89609703
147MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89448455
148FLI1_21867929_ChIP-Seq_TH2_Mouse0.89393363
149CBP_20019798_ChIP-Seq_JUKART_Human0.89234929
150IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89234929
151ER_23166858_ChIP-Seq_MCF-7_Human0.88691601
152RUNX2_22187159_ChIP-Seq_PCA_Human0.88269813
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87848432
154DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87719742
155KDM2B_26808549_Chip-Seq_K562_Human0.87557815
156CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87440529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.47887881
2MP0005551_abnormal_eye_electrophysiolog3.67724139
3* MP0005464_abnormal_platelet_physiology3.46714289
4MP0002822_catalepsy3.43266133
5MP0003635_abnormal_synaptic_transmissio3.41192526
6MP0003880_abnormal_central_pattern3.33632748
7MP0002090_abnormal_vision3.06210402
8MP0002837_dystrophic_cardiac_calcinosis2.90562748
9MP0009745_abnormal_behavioral_response2.79396337
10MP0002063_abnormal_learning/memory/cond2.77234122
11MP0003724_increased_susceptibility_to2.64936278
12MP0001984_abnormal_olfaction2.55307481
13MP0002064_seizures2.54859835
14MP0006072_abnormal_retinal_apoptosis2.52934958
15MP0000465_gastrointestinal_hemorrhage2.45617950
16MP0004270_analgesia2.43955894
17MP0002009_preneoplasia2.43057509
18MP0009046_muscle_twitch2.42119760
19MP0005423_abnormal_somatic_nervous2.41467264
20MP0001486_abnormal_startle_reflex2.41003319
21MP0001502_abnormal_circadian_rhythm2.39788780
22MP0002272_abnormal_nervous_system2.32677968
23MP0001968_abnormal_touch/_nociception2.30498948
24MP0002734_abnormal_mechanical_nocicepti2.28380194
25MP0005397_hematopoietic_system_phenotyp2.25842881
26MP0001545_abnormal_hematopoietic_system2.25842881
27MP0008004_abnormal_stomach_pH2.21346128
28MP0002572_abnormal_emotion/affect_behav2.18174992
29MP0004084_abnormal_cardiac_muscle2.05753017
30MP0002166_altered_tumor_susceptibility1.95721447
31MP0005220_abnormal_exocrine_pancreas1.94358241
32MP0001501_abnormal_sleep_pattern1.85001591
33MP0001188_hyperpigmentation1.84766458
34MP0002638_abnormal_pupillary_reflex1.84513894
35MP0004510_myositis1.78451397
36MP0004036_abnormal_muscle_relaxation1.77725247
37MP0010386_abnormal_urinary_bladder1.76708130
38MP0004808_abnormal_hematopoietic_stem1.75349888
39MP0002184_abnormal_innervation1.74272633
40MP0004233_abnormal_muscle_weight1.73509235
41MP0002067_abnormal_sensory_capabilities1.71316493
42MP0005253_abnormal_eye_physiology1.67462500
43MP0009780_abnormal_chondrocyte_physiolo1.64846457
44MP0008569_lethality_at_weaning1.63336441
45MP0010368_abnormal_lymphatic_system1.58135492
46MP0004215_abnormal_myocardial_fiber1.57412010
47MP0004085_abnormal_heartbeat1.57302003
48MP0003879_abnormal_hair_cell1.53895196
49MP0005386_behavior/neurological_phenoty1.53808369
50MP0004924_abnormal_behavior1.53808369
51MP0002909_abnormal_adrenal_gland1.53439058
52MP0002736_abnormal_nociception_after1.51056911
53MP0002557_abnormal_social/conspecific_i1.50741932
54MP0003283_abnormal_digestive_organ1.48462480
55MP0009697_abnormal_copulation1.45706853
56MP0001970_abnormal_pain_threshold1.45587904
57MP0005646_abnormal_pituitary_gland1.43569989
58MP0005410_abnormal_fertilization1.43422097
59MP0003122_maternal_imprinting1.39037941
60MP0004782_abnormal_surfactant_physiolog1.38364248
61MP0005195_abnormal_posterior_eye1.37397375
62MP0004811_abnormal_neuron_physiology1.37371373
63MP0003828_pulmonary_edema1.35238102
64MP0002876_abnormal_thyroid_physiology1.34830002
65MP0002882_abnormal_neuron_morphology1.34322134
66MP0001440_abnormal_grooming_behavior1.34314933
67MP0000778_abnormal_nervous_system1.33392336
68MP0000751_myopathy1.33199372
69MP0001879_abnormal_lymphatic_vessel1.31194282
70MP0001986_abnormal_taste_sensitivity1.30658139
71MP0000013_abnormal_adipose_tissue1.28596668
72MP0002396_abnormal_hematopoietic_system1.28333005
73MP0000516_abnormal_urinary_system1.28195653
74MP0005367_renal/urinary_system_phenotyp1.28195653
75MP0001529_abnormal_vocalization1.27709080
76MP0002138_abnormal_hepatobiliary_system1.27477219
77MP0000383_abnormal_hair_follicle1.26652910
78MP0001851_eye_inflammation1.26620648
79MP0002006_tumorigenesis1.26304299
80MP0002733_abnormal_thermal_nociception1.25107857
81MP0003045_fibrosis1.24004061
82MP0004858_abnormal_nervous_system1.21863220
83MP0004130_abnormal_muscle_cell1.21828168
84MP0000955_abnormal_spinal_cord1.21645686
85MP0005165_increased_susceptibility_to1.20630589
86MP0003633_abnormal_nervous_system1.19420978
87MP0005275_abnormal_skin_tensile1.19013731
88MP0005620_abnormal_muscle_contractility1.17853753
89MP0000631_abnormal_neuroendocrine_gland1.17755039
90MP0004885_abnormal_endolymph1.17404500
91MP0001835_abnormal_antigen_presentation1.16663131
92MP0009278_abnormal_bone_marrow1.16569168
93MP0006276_abnormal_autonomic_nervous1.16494815
94MP0001756_abnormal_urination1.15494710
95MP0000372_irregular_coat_pigmentation1.15476566
96MP0005248_abnormal_Harderian_gland1.15132322
97MP0003137_abnormal_impulse_conducting1.15015277
98MP0003195_calcinosis1.14748075
99MP0005330_cardiomyopathy1.14244328
100MP0002735_abnormal_chemical_nociception1.13450662
101MP0005385_cardiovascular_system_phenoty1.12648656
102MP0001544_abnormal_cardiovascular_syste1.12648656
103MP0002693_abnormal_pancreas_physiology1.12441693
104MP0001177_atelectasis1.11542419
105MP0002229_neurodegeneration1.10734161
106MP0002752_abnormal_somatic_nervous1.09397049
107* MP0008775_abnormal_heart_ventricle1.08817910
108MP0002234_abnormal_pharynx_morphology1.07592720
109MP0002066_abnormal_motor_capabilities/c1.07026670
110MP0005535_abnormal_body_temperature1.05671104
111MP0001765_abnormal_ion_homeostasis1.05245885
112MP0006292_abnormal_olfactory_placode1.04458930
113MP0002148_abnormal_hypersensitivity_rea1.03058345
114MP0004043_abnormal_pH_regulation1.02371026
115MP0002132_abnormal_respiratory_system1.01406979
116MP0003183_abnormal_peptide_metabolism1.00669208
117MP0000681_abnormal_thyroid_gland0.97457413
118MP0003329_amyloid_beta_deposits0.97082162
119MP0006138_congestive_heart_failure0.95496410
120MP0000534_abnormal_ureter_morphology0.95230449
121MP0004145_abnormal_muscle_electrophysio0.95135684
122MP0002152_abnormal_brain_morphology0.93145545
123MP0003638_abnormal_response/metabolism_0.92837498
124MP0006036_abnormal_mitochondrial_physio0.90728993
125MP0003866_abnormal_defecation0.90665441
126* MP0005595_abnormal_vascular_smooth0.90169570
127MP0002332_abnormal_exercise_endurance0.89660382
128MP0005409_darkened_coat_color0.87743676
129MP0005645_abnormal_hypothalamus_physiol0.87493402
130MP0003787_abnormal_imprinting0.86629103
131MP0003631_nervous_system_phenotype0.85643748
132MP0001661_extended_life_span0.85055177
133MP0010678_abnormal_skin_adnexa0.84191010
134MP0008872_abnormal_physiological_respon0.83565600
135MP0001664_abnormal_digestion0.83384060
136MP0002972_abnormal_cardiac_muscle0.82272914
137MP0003303_peritoneal_inflammation0.82088928
138MP0002069_abnormal_eating/drinking_beha0.81936086
139MP0005499_abnormal_olfactory_system0.80334101
140MP0005394_taste/olfaction_phenotype0.80334101
141MP0005167_abnormal_blood-brain_barrier0.79888403
142MP0000462_abnormal_digestive_system0.78576011
143MP0003634_abnormal_glial_cell0.78552794
144MP0005623_abnormal_meninges_morphology0.76791333
145MP0002128_abnormal_blood_circulation0.76600786
146MP0005503_abnormal_tendon_morphology0.74898402
147MP0005670_abnormal_white_adipose0.74551671
148MP0006054_spinal_hemorrhage0.74419359
149MP0010630_abnormal_cardiac_muscle0.73904547
150MP0004484_altered_response_of0.72309835
151MP0004142_abnormal_muscle_tone0.70414505
152MP0003075_altered_response_to0.70379673
153MP0005647_abnormal_sex_gland0.69407494
154MP0005187_abnormal_penis_morphology0.68378266
155* MP0000230_abnormal_systemic_arterial0.67979662
156MP0005084_abnormal_gallbladder_morpholo0.65238070
157MP0000538_abnormal_urinary_bladder0.65182503
158MP0008874_decreased_physiological_sensi0.65101428
159MP0002078_abnormal_glucose_homeostasis0.64698958
160MP0004742_abnormal_vestibular_system0.63533403
161MP0001963_abnormal_hearing_physiology0.62505363
162MP0002127_abnormal_cardiovascular_syste0.61905252
163MP0001905_abnormal_dopamine_level0.61376927
164MP0001943_abnormal_respiration0.60585769

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.63903868
2Prolonged bleeding time (HP:0003010)6.18642646
3Central scotoma (HP:0000603)5.43683194
4Epileptic encephalopathy (HP:0200134)5.32576040
5Right ventricular cardiomyopathy (HP:0011663)5.25293411
6Focal motor seizures (HP:0011153)4.71022345
7Myokymia (HP:0002411)4.59106648
8Febrile seizures (HP:0002373)4.53395772
9Increased mean platelet volume (HP:0011877)4.34539071
10Severe visual impairment (HP:0001141)4.31271837
11Menorrhagia (HP:0000132)4.05114401
12Visual hallucinations (HP:0002367)4.04893362
13Absence seizures (HP:0002121)4.01944685
14Petechiae (HP:0000967)3.98688333
15Abnormality of macular pigmentation (HP:0008002)3.95366701
16Abnormal platelet volume (HP:0011876)3.95067404
17Bundle branch block (HP:0011710)3.83644542
18Scotoma (HP:0000575)3.79153378
19Focal seizures (HP:0007359)3.78211240
20Epistaxis (HP:0000421)3.77418137
21Abnormal rod and cone electroretinograms (HP:0008323)3.68428590
22Metaphyseal dysplasia (HP:0100255)3.60867433
23Sudden death (HP:0001699)3.49385795
24Purpura (HP:0000979)3.44928263
25Dialeptic seizures (HP:0011146)3.38998969
26Ventricular tachycardia (HP:0004756)3.33081336
27Progressive cerebellar ataxia (HP:0002073)3.30658119
28Gingival bleeding (HP:0000225)3.24023741
29Calf muscle hypertrophy (HP:0008981)3.19564933
30Prolonged QT interval (HP:0001657)3.16314780
31Septo-optic dysplasia (HP:0100842)3.12183302
32Abnormality of the prostate (HP:0008775)3.11642286
33Decreased central vision (HP:0007663)3.05351001
34Dysdiadochokinesis (HP:0002075)3.04056896
35Mutism (HP:0002300)3.02756382
36Depression (HP:0000716)3.01713419
37Action tremor (HP:0002345)3.00682880
38Muscle hypertrophy of the lower extremities (HP:0008968)2.94683109
39Ketoacidosis (HP:0001993)2.87128884
40Generalized tonic-clonic seizures (HP:0002069)2.85812332
41Renal cortical cysts (HP:0000803)2.82131314
42Torticollis (HP:0000473)2.81240738
43Panhypogammaglobulinemia (HP:0003139)2.80696226
44Palpitations (HP:0001962)2.79060987
45Bony spicule pigmentary retinopathy (HP:0007737)2.75039905
46Atonic seizures (HP:0010819)2.74952124
47Autoimmune hemolytic anemia (HP:0001890)2.68635434
48Decreased circulating renin level (HP:0003351)2.68569566
49Ankle clonus (HP:0011448)2.63703444
50Hyperthyroidism (HP:0000836)2.63652897
51Acute lymphatic leukemia (HP:0006721)2.62373390
52Anxiety (HP:0000739)2.61973272
53Prostate neoplasm (HP:0100787)2.60525647
54Scanning speech (HP:0002168)2.56433026
55Broad-based gait (HP:0002136)2.55517870
56Ventricular arrhythmia (HP:0004308)2.55190714
57Genetic anticipation (HP:0003743)2.54595392
58Poor eye contact (HP:0000817)2.51317572
59Spontaneous hematomas (HP:0007420)2.50548030
60Abnormality of the renal cortex (HP:0011035)2.49495168
61Heart block (HP:0012722)2.45227255
62Abnormal EKG (HP:0003115)2.43600267
63Epileptiform EEG discharges (HP:0011182)2.43198001
64EEG with generalized epileptiform discharges (HP:0011198)2.42943312
65Supranuclear gaze palsy (HP:0000605)2.42864218
66Cholecystitis (HP:0001082)2.42122171
67Abnormal gallbladder physiology (HP:0012438)2.42122171
68Agammaglobulinemia (HP:0004432)2.42010159
69Hypothermia (HP:0002045)2.41283935
70Ketosis (HP:0001946)2.40598107
71Excessive salivation (HP:0003781)2.38966308
72Drooling (HP:0002307)2.38966308
73Atrial fibrillation (HP:0005110)2.37759681
74Abnormality of the calf musculature (HP:0001430)2.27504326
75Stomach cancer (HP:0012126)2.26432109
76Primary atrial arrhythmia (HP:0001692)2.26060690
77Focal dystonia (HP:0004373)2.23901695
78Impaired social interactions (HP:0000735)2.20027947
79Abnormal social behavior (HP:0012433)2.20027947
80Abnormal eating behavior (HP:0100738)2.19502226
81Abolished electroretinogram (ERG) (HP:0000550)2.18376380
82Abnormal pupillary function (HP:0007686)2.18326031
83Insulin-resistant diabetes mellitus (HP:0000831)2.18167631
84Craniofacial dystonia (HP:0012179)2.16970009
85Neoplasm of the heart (HP:0100544)2.16617492
86Acute myeloid leukemia (HP:0004808)2.15978311
87Truncal ataxia (HP:0002078)2.14081794
88Supraventricular tachycardia (HP:0004755)2.13775447
89Gaze-evoked nystagmus (HP:0000640)2.13509186
90Limb dystonia (HP:0002451)2.13407815
91Testicular neoplasm (HP:0010788)2.13211496
92Supraventricular arrhythmia (HP:0005115)2.11019384
93Severe Myopia (HP:0011003)2.10594477
94Gait imbalance (HP:0002141)2.09088449
95Spontaneous abortion (HP:0005268)2.08954896
96Postural instability (HP:0002172)2.08140279
97Hyperventilation (HP:0002883)2.07614895
98Broad metatarsal (HP:0001783)2.07070590
99Rimmed vacuoles (HP:0003805)2.06614329
100Urinary bladder sphincter dysfunction (HP:0002839)2.04899654
101Hemiplegia (HP:0002301)2.04889185
102Hypoplasia of the fovea (HP:0007750)2.03084899
103Aplasia/Hypoplasia of the fovea (HP:0008060)2.03084899
104Abnormal atrioventricular conduction (HP:0005150)2.03001306
105Polyphagia (HP:0002591)2.02556876
106Absent speech (HP:0001344)2.01211765
107Hypoglycemic coma (HP:0001325)1.98540251
108Dysmetria (HP:0001310)1.98288255
109Incomplete penetrance (HP:0003829)1.97907556
110Stereotypic behavior (HP:0000733)1.97561898
111Annular pancreas (HP:0001734)1.96249120
112Ventricular fibrillation (HP:0001663)1.95455306
113Impaired platelet aggregation (HP:0003540)1.94900947
114Abnormal platelet function (HP:0011869)1.94900947
115Papilledema (HP:0001085)1.94777556
116Long toe (HP:0010511)1.94019719
117Thyroid-stimulating hormone excess (HP:0002925)1.93644178
118Hypsarrhythmia (HP:0002521)1.92705303
119Thyroiditis (HP:0100646)1.92211745
120Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90691944
121Amblyopia (HP:0000646)1.90649523
122Abnormality of B cell number (HP:0010975)1.90443628
123Exercise-induced myalgia (HP:0003738)1.89604506
124Metabolic alkalosis (HP:0200114)1.87406933
125Agitation (HP:0000713)1.87357950
126Dyschromatopsia (HP:0007641)1.86595978
127Dilated cardiomyopathy (HP:0001644)1.86227571
128Papillary thyroid carcinoma (HP:0002895)1.84014417
129Abnormal drinking behavior (HP:0030082)1.83344104
130Polydipsia (HP:0001959)1.83344104
131Bradykinesia (HP:0002067)1.83008435
132Elfin facies (HP:0004428)1.82714555
133Hyperglycemia (HP:0003074)1.82082391
134Abnormality of the lower motor neuron (HP:0002366)1.79695959
135Thrombocytosis (HP:0001894)1.79260898
136Abnormality of male internal genitalia (HP:0000022)1.78035980
137Insomnia (HP:0100785)1.77136598
138Syncope (HP:0001279)1.77059702
139Pointed chin (HP:0000307)1.76396240
140Bruising susceptibility (HP:0000978)1.76216544
141Impaired smooth pursuit (HP:0007772)1.76190454
142Flat cornea (HP:0007720)1.75883083
143Abnormality of renin-angiotensin system (HP:0000847)1.75606173
144Abnormality of the pancreatic islet cells (HP:0006476)1.75160410
145Abnormality of endocrine pancreas physiology (HP:0012093)1.75160410
146Anhidrosis (HP:0000970)1.74517175
147Portal hypertension (HP:0001409)1.74391741
148Atrioventricular block (HP:0001678)1.74315825
149Pancreatic fibrosis (HP:0100732)1.74192265
150Impaired vibration sensation in the lower limbs (HP:0002166)1.74127414
151Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73747665
152Keratoconus (HP:0000563)1.73738993
153Increased corneal curvature (HP:0100692)1.73738993
154Spinal canal stenosis (HP:0003416)1.73723141
155Intention tremor (HP:0002080)1.73141083
156Retinal dysplasia (HP:0007973)1.73072600
157Hypoproteinemia (HP:0003075)1.72636794
158Poikilocytosis (HP:0004447)1.72418170
159Hepatoblastoma (HP:0002884)1.71505814
160Facial diplegia (HP:0001349)1.71112998
161Short chin (HP:0000331)1.70908413
162Abnormality of the heme biosynthetic pathway (HP:0010472)1.70605159
163Sudden cardiac death (HP:0001645)1.70141732
164Hypokalemic alkalosis (HP:0001949)1.69849813
165Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69222123
166Fetal akinesia sequence (HP:0001989)1.69151057
167Abnormality of the renal medulla (HP:0100957)1.68770393
168Pigmentary retinal degeneration (HP:0001146)1.68757224
169Centrally nucleated skeletal muscle fibers (HP:0003687)1.68583933
170Dysmetric saccades (HP:0000641)1.67896527
171Progressive inability to walk (HP:0002505)1.67309695
172Attenuation of retinal blood vessels (HP:0007843)1.67005893
173Abnormality of the fovea (HP:0000493)1.66679309
174Left ventricular hypertrophy (HP:0001712)1.66152957
175Bradycardia (HP:0001662)1.66075802
176Optic nerve hypoplasia (HP:0000609)1.65792144
177Asymmetric septal hypertrophy (HP:0001670)1.65689307
178Megalencephaly (HP:0001355)1.65626425
179Lipoatrophy (HP:0100578)1.65625574
180Status epilepticus (HP:0002133)1.65273682
181Absent septum pellucidum (HP:0001331)1.64674974
182Biliary tract neoplasm (HP:0100574)1.64583477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.24575600
2TAOK34.05489977
3EPHA43.75034914
4KIT3.11460574
5FLT33.11075590
6OBSCN3.09545446
7MAP3K92.92591334
8PRPF4B2.82762243
9NTRK32.79921168
10MAP3K42.67317431
11MINK12.61575748
12PAK62.41334570
13DAPK22.31518611
14TEC2.27139148
15CASK2.13259322
16PHKG12.06663076
17PHKG22.06663076
18BCKDK1.79274803
19RIPK11.77518664
20PKN21.75738581
21TNIK1.72845899
22NUAK11.70667191
23TRPM71.69764783
24MAP2K71.68678604
25NTRK21.66666945
26PIK3CG1.62294246
27CAMKK11.61549634
28MAP4K21.60007722
29GRK11.59361181
30MST41.56492064
31SYK1.54122949
32NTRK11.53224026
33ADRBK21.52399695
34KSR21.49425796
35PIK3CA1.48666873
36TIE11.41027198
37CDK51.39924107
38KSR11.38763524
39CSF1R1.33795104
40CAMK11.31409520
41DYRK1A1.31223341
42BTK1.29866092
43MAPK131.26713996
44SGK4941.24389144
45SGK2231.24389144
46MYLK1.19948519
47STK391.19867143
48STK381.19855512
49MAP3K131.18461277
50PRKD31.16348148
51ITK1.14525373
52FES1.14402390
53INSRR1.14098983
54MAP2K41.13500152
55CAMKK21.10375269
56NEK11.09375705
57RIPK41.05808490
58TAOK21.05264072
59PINK11.04906550
60DAPK11.03678750
61PRKCG1.03607110
62AKT31.03311909
63DMPK1.03014559
64SGK20.99937823
65CAMK2A0.96179786
66EPHA30.95921412
67LATS10.93726530
68CAMK1G0.93145875
69SCYL20.91412121
70MARK20.91303994
71PAK30.90212833
72GRK50.89994732
73MAP3K120.89327256
74IRAK10.89127876
75FGFR30.89004839
76TBK10.87673398
77MAPKAPK30.87439290
78CDK140.86393168
79ARAF0.86246190
80STK38L0.85429480
81BMPR20.84624025
82PRKCE0.83522391
83SIK20.83346339
84CDK180.82660298
85CDK150.82190160
86PLK20.81602663
87SGK30.81340784
88ERBB30.79293483
89CAMK2D0.78123944
90PTK2B0.76468706
91HIPK20.76310877
92MAP3K70.74097944
93CAMK40.73905045
94MAP3K10.72563723
95TNK20.72074900
96CAMK1D0.69877587
97GRK70.68507791
98CDK11A0.67819953
99SGK10.67026676
100IKBKB0.66831289
101PRKD10.65357830
102CDC42BPA0.64948638
103WNK30.64815940
104RAF10.63728147
105UHMK10.62346835
106PRKCH0.62296181
107IKBKE0.62236971
108CCNB10.61660790
109PRKCZ0.60696421
110TAF10.60615346
111PRKG10.60570215
112FER0.59760364
113JAK30.59539680
114PRKAA20.58925282
115ROCK10.58884854
116FGFR20.58627409
117RET0.57301650
118CAMK2B0.57209671
119LYN0.57150935
120STK110.55790062
121CSNK1G20.55405462
122PRKCQ0.54971233
123FRK0.54435083
124LATS20.54298921
125PKN10.54027385
126MAPK120.53974070
127RPS6KA30.53371194
128NEK60.53285661
129FYN0.52686306
130HCK0.52684700
131RPS6KA20.51406286
132GRK60.51050547
133OXSR10.49654244
134PRKD20.48936308
135PRKAA10.48795864
136MAP2K60.47632996
137ROCK20.47616808
138TAOK10.47027273
139LCK0.46489481
140ZAP700.46370249
141BMPR1B0.45551683
142MAPK70.45323237
143STK30.44765484
144MAPKAPK50.44510404
145PRKACG0.44508778
146DAPK30.44042957
147MAPK100.43376901
148LMTK20.43372964
149MAPK30.42190557
150PRKACA0.42098531
151ADRBK10.42065785
152MAP2K10.41998302
153PRKG20.41737292
154NLK0.41712362
155KDR0.41616759
156MATK0.40968289
157ACVR1B0.40461165
158IGF1R0.39994812
159JAK20.38241406
160MAP2K20.36860305
161CSNK1G30.36331997

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.91404240
2GABAergic synapse_Homo sapiens_hsa047273.25721357
3Synaptic vesicle cycle_Homo sapiens_hsa047213.19790630
4Morphine addiction_Homo sapiens_hsa050323.05999403
5Asthma_Homo sapiens_hsa053103.04243291
6Olfactory transduction_Homo sapiens_hsa047402.93965049
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87718745
8* Circadian entrainment_Homo sapiens_hsa047132.65966651
9Type I diabetes mellitus_Homo sapiens_hsa049402.30340551
10Glutamatergic synapse_Homo sapiens_hsa047242.27277926
11Allograft rejection_Homo sapiens_hsa053302.17421517
12Cholinergic synapse_Homo sapiens_hsa047252.06340354
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.05943885
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.03064681
15Insulin secretion_Homo sapiens_hsa049112.02452914
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00500914
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.99471818
18* Renin secretion_Homo sapiens_hsa049241.93626683
19* Salivary secretion_Homo sapiens_hsa049701.85796538
20Autoimmune thyroid disease_Homo sapiens_hsa053201.85581699
21Dopaminergic synapse_Homo sapiens_hsa047281.85479054
22* Oxytocin signaling pathway_Homo sapiens_hsa049211.76364935
23Graft-versus-host disease_Homo sapiens_hsa053321.76261237
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74840575
25Serotonergic synapse_Homo sapiens_hsa047261.73913414
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73822371
27Amphetamine addiction_Homo sapiens_hsa050311.73380407
28Arachidonic acid metabolism_Homo sapiens_hsa005901.70871643
29Circadian rhythm_Homo sapiens_hsa047101.68836661
30Phototransduction_Homo sapiens_hsa047441.63665664
31Dilated cardiomyopathy_Homo sapiens_hsa054141.63044775
32Cardiac muscle contraction_Homo sapiens_hsa042601.58746061
33Long-term potentiation_Homo sapiens_hsa047201.56986107
34Calcium signaling pathway_Homo sapiens_hsa040201.55126089
35Cocaine addiction_Homo sapiens_hsa050301.52973049
36Linoleic acid metabolism_Homo sapiens_hsa005911.50058800
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49543825
38Tryptophan metabolism_Homo sapiens_hsa003801.47597953
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46998459
40Taste transduction_Homo sapiens_hsa047421.45001239
41* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.38303826
42Gastric acid secretion_Homo sapiens_hsa049711.36186720
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35987257
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34898532
45cAMP signaling pathway_Homo sapiens_hsa040241.34158032
46* Gap junction_Homo sapiens_hsa045401.33941113
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33600804
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32300961
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31933216
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30703113
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29954059
52Staphylococcus aureus infection_Homo sapiens_hsa051501.29643272
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18167901
54Leishmaniasis_Homo sapiens_hsa051401.17478586
55ABC transporters_Homo sapiens_hsa020101.17470592
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16804807
57* Vascular smooth muscle contraction_Homo sapiens_hsa042701.13578857
58Hematopoietic cell lineage_Homo sapiens_hsa046401.12366023
59ECM-receptor interaction_Homo sapiens_hsa045121.11680455
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09176863
61GnRH signaling pathway_Homo sapiens_hsa049121.09107086
62* Long-term depression_Homo sapiens_hsa047301.08154223
63Fatty acid biosynthesis_Homo sapiens_hsa000611.06560651
64Axon guidance_Homo sapiens_hsa043601.06521649
65Butanoate metabolism_Homo sapiens_hsa006501.05821119
66Propanoate metabolism_Homo sapiens_hsa006400.99555575
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99021174
68Nitrogen metabolism_Homo sapiens_hsa009100.98539254
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97988112
70Type II diabetes mellitus_Homo sapiens_hsa049300.96800894
71Collecting duct acid secretion_Homo sapiens_hsa049660.93897121
72Peroxisome_Homo sapiens_hsa041460.92948840
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92190600
74Ether lipid metabolism_Homo sapiens_hsa005650.90784426
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.89030834
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.88640378
77Renin-angiotensin system_Homo sapiens_hsa046140.88418673
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.85211822
79Chemical carcinogenesis_Homo sapiens_hsa052040.84959895
80Rheumatoid arthritis_Homo sapiens_hsa053230.82209185
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82113507
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.81281012
83Estrogen signaling pathway_Homo sapiens_hsa049150.80273644
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.78567573
85Glioma_Homo sapiens_hsa052140.77336627
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73274651
87Fructose and mannose metabolism_Homo sapiens_hsa000510.72377865
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71502692
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71461560
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71340393
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70808247
92MAPK signaling pathway_Homo sapiens_hsa040100.68590459
93Mineral absorption_Homo sapiens_hsa049780.66220790
94Melanogenesis_Homo sapiens_hsa049160.65496436
95Pancreatic secretion_Homo sapiens_hsa049720.65259468
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64862401
97Systemic lupus erythematosus_Homo sapiens_hsa053220.64860249
98Toxoplasmosis_Homo sapiens_hsa051450.64263303
99Regulation of autophagy_Homo sapiens_hsa041400.64033130
100ErbB signaling pathway_Homo sapiens_hsa040120.61893133
101B cell receptor signaling pathway_Homo sapiens_hsa046620.61726038
102Dorso-ventral axis formation_Homo sapiens_hsa043200.61252201
103Ovarian steroidogenesis_Homo sapiens_hsa049130.59895346
104Alcoholism_Homo sapiens_hsa050340.59481386
105Endometrial cancer_Homo sapiens_hsa052130.59346055
106Ras signaling pathway_Homo sapiens_hsa040140.59146216
107Renal cell carcinoma_Homo sapiens_hsa052110.58626822
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58109626
109Thyroid hormone synthesis_Homo sapiens_hsa049180.57734181
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55168915
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.54561083
112Viral myocarditis_Homo sapiens_hsa054160.54342902
113Glucagon signaling pathway_Homo sapiens_hsa049220.53627655
114Fatty acid degradation_Homo sapiens_hsa000710.53534400
115Fatty acid metabolism_Homo sapiens_hsa012120.53422600
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53333684
117Bile secretion_Homo sapiens_hsa049760.52901209
118Rap1 signaling pathway_Homo sapiens_hsa040150.52809782
119Amoebiasis_Homo sapiens_hsa051460.51050355
120Choline metabolism in cancer_Homo sapiens_hsa052310.50754413
121Insulin resistance_Homo sapiens_hsa049310.50524033
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50098355
123Sphingolipid metabolism_Homo sapiens_hsa006000.49512467
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46965556
125Vibrio cholerae infection_Homo sapiens_hsa051100.46878523
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46688171
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45437614
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44893929
129mTOR signaling pathway_Homo sapiens_hsa041500.42967428
130Fatty acid elongation_Homo sapiens_hsa000620.42222220
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42041979
132Inositol phosphate metabolism_Homo sapiens_hsa005620.41313965
133Antigen processing and presentation_Homo sapiens_hsa046120.40467125
134Retinol metabolism_Homo sapiens_hsa008300.39794302
135Oocyte meiosis_Homo sapiens_hsa041140.39601110
136Glycerolipid metabolism_Homo sapiens_hsa005610.38354718
137Primary immunodeficiency_Homo sapiens_hsa053400.38177653
138HIF-1 signaling pathway_Homo sapiens_hsa040660.36934583
139Protein digestion and absorption_Homo sapiens_hsa049740.36644150
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.35778872
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34838240
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34276945
143VEGF signaling pathway_Homo sapiens_hsa043700.32821444
144Endocytosis_Homo sapiens_hsa041440.32569360
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32138450
146Insulin signaling pathway_Homo sapiens_hsa049100.31997769
147Colorectal cancer_Homo sapiens_hsa052100.31741541
148Melanoma_Homo sapiens_hsa052180.30776957
149Chemokine signaling pathway_Homo sapiens_hsa040620.27610943
150Wnt signaling pathway_Homo sapiens_hsa043100.26050788
151Biosynthesis of amino acids_Homo sapiens_hsa012300.25369572
152AMPK signaling pathway_Homo sapiens_hsa041520.24983468
153Focal adhesion_Homo sapiens_hsa045100.24911511
154Galactose metabolism_Homo sapiens_hsa000520.23798501
155* Platelet activation_Homo sapiens_hsa046110.23610573

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