GUCA2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular ketone body metabolic process (GO:0046950)9.58748683
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.61156813
3pyrimidine-containing compound transmembrane transport (GO:0072531)8.49373769
4ketone body metabolic process (GO:1902224)8.36541794
5vitamin transmembrane transport (GO:0035461)7.65341476
6NADH metabolic process (GO:0006734)7.40016327
7purine ribonucleoside bisphosphate metabolic process (GO:0034035)7.12099461
83-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)7.12099461
9epoxygenase P450 pathway (GO:0019373)6.84821027
10lipoprotein transport (GO:0042953)6.82220779
11fat-soluble vitamin biosynthetic process (GO:0042362)6.75074261
12sulfur amino acid catabolic process (GO:0000098)5.96417989
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.87068630
14fructose metabolic process (GO:0006000)5.83827283
15regulation of bile acid biosynthetic process (GO:0070857)5.74168175
16regulation of systemic arterial blood pressure by hormone (GO:0001990)5.63302327
17regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.63302327
18endocrine process (GO:0050886)5.63302327
19flavonoid metabolic process (GO:0009812)5.57394600
20sulfate transmembrane transport (GO:1902358)5.56005903
21negative regulation of T cell differentiation in thymus (GO:0033085)5.41030841
22hormone catabolic process (GO:0042447)5.39829266
23chondrocyte proliferation (GO:0035988)5.38634154
24bile acid and bile salt transport (GO:0015721)5.35516727
25cytidine metabolic process (GO:0046087)5.21263633
26cytidine catabolic process (GO:0006216)5.21263633
27cytidine deamination (GO:0009972)5.21263633
28intestinal epithelial cell development (GO:0060576)5.21011418
29ATP synthesis coupled proton transport (GO:0015986)5.10942171
30energy coupled proton transport, down electrochemical gradient (GO:0015985)5.10942171
31regulation of systemic arterial blood pressure (GO:0003073)5.06355814
32regulation of cellular extravasation (GO:0002691)5.04963291
33drug metabolic process (GO:0017144)4.97349007
34virion attachment to host cell (GO:0019062)4.79981553
35adhesion of symbiont to host cell (GO:0044650)4.79981553
36diacylglycerol metabolic process (GO:0046339)4.76779544
37renal system process involved in regulation of blood volume (GO:0001977)4.75528057
38sulfur compound transport (GO:0072348)4.66174586
39cGMP-mediated signaling (GO:0019934)4.65722110
40regulation of triglyceride catabolic process (GO:0010896)4.63287283
41calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.61696226
42regulation of vitamin metabolic process (GO:0030656)4.61614321
43bundle of His cell to Purkinje myocyte communication (GO:0086069)4.60253786
44very-low-density lipoprotein particle assembly (GO:0034379)4.60139488
45positive regulation of T cell differentiation in thymus (GO:0033089)4.58980202
46sulfate transport (GO:0008272)4.56171958
47peptide hormone processing (GO:0016486)4.37320649
48urea cycle (GO:0000050)4.33804567
49receptor guanylyl cyclase signaling pathway (GO:0007168)4.31307365
50peptide catabolic process (GO:0043171)4.31192006
51digestion (GO:0007586)4.27143378
52somite development (GO:0061053)4.27003272
53ribonucleoside bisphosphate biosynthetic process (GO:0034030)4.21355433
54nucleoside bisphosphate biosynthetic process (GO:0033866)4.21355433
55purine nucleoside bisphosphate biosynthetic process (GO:0034033)4.21355433
56desmosome organization (GO:0002934)4.20130306
57urea metabolic process (GO:0019627)4.14246143
58vitamin A metabolic process (GO:0006776)4.11828703
59plasma lipoprotein particle assembly (GO:0034377)4.11048186
60glycolipid catabolic process (GO:0019377)4.10718185
61respiratory electron transport chain (GO:0022904)4.10329497
62adhesion of symbiont to host (GO:0044406)4.07374435
63negative regulation of alpha-beta T cell differentiation (GO:0046639)4.04396661
64glycosphingolipid catabolic process (GO:0046479)4.03314726
65electron transport chain (GO:0022900)4.00059150
66epithelial cell-cell adhesion (GO:0090136)3.98057034
67cellular response to nitric oxide (GO:0071732)3.95369933
68neurotransmitter biosynthetic process (GO:0042136)3.93846088
69ATP biosynthetic process (GO:0006754)3.92769713
70bicarbonate transport (GO:0015701)3.92011907
71inner mitochondrial membrane organization (GO:0007007)3.86169269
72nitrogen cycle metabolic process (GO:0071941)3.83074005
73UDP-N-acetylglucosamine metabolic process (GO:0006047)3.82729081
74nucleoside bisphosphate metabolic process (GO:0033865)3.81466690
75purine nucleoside bisphosphate metabolic process (GO:0034032)3.81466690
76ribonucleoside bisphosphate metabolic process (GO:0033875)3.81466690
77nucleotide-sugar biosynthetic process (GO:0009226)3.81238395
78phosphate ion transmembrane transport (GO:0035435)3.80687533
79positive regulation of glycoprotein biosynthetic process (GO:0010560)3.79133343
80regulation of pseudopodium assembly (GO:0031272)3.78199901
81vitamin transport (GO:0051180)3.76110167
82protein-lipid complex assembly (GO:0065005)3.74849923
83homocysteine metabolic process (GO:0050667)3.68788186
84extracellular matrix assembly (GO:0085029)3.67950250
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67455641
86GDP-mannose metabolic process (GO:0019673)3.67243675
87cellular glucuronidation (GO:0052695)3.65243502
88regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.64776088
89nucleoside diphosphate biosynthetic process (GO:0009133)3.63775112
90antibacterial humoral response (GO:0019731)3.62750729
91fat-soluble vitamin metabolic process (GO:0006775)3.62010692
92* positive regulation of guanylate cyclase activity (GO:0031284)3.61385099
93bone resorption (GO:0045453)3.60334421
94cGMP biosynthetic process (GO:0006182)3.59610590
95lipoprotein metabolic process (GO:0042157)3.57789952
96phenol-containing compound catabolic process (GO:0019336)3.57162400
97galactose catabolic process (GO:0019388)3.56471129
98response to nitric oxide (GO:0071731)3.55280594
99drinking behavior (GO:0042756)3.54769211
100antimicrobial humoral response (GO:0019730)3.54452539
101actin filament depolymerization (GO:0030042)3.52253331
102sulfation (GO:0051923)3.49339694
103pyrimidine ribonucleoside catabolic process (GO:0046133)3.46815281
104positive regulation of glycoprotein metabolic process (GO:1903020)3.43818688
105* regulation of cGMP biosynthetic process (GO:0030826)3.43741642
106positive regulation of prostaglandin secretion (GO:0032308)3.43658884
107fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.42548525
108intestinal absorption (GO:0050892)3.42538096
109phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.39253762
110negative regulation of keratinocyte proliferation (GO:0010839)3.38862670
111maintenance of gastrointestinal epithelium (GO:0030277)3.38832525
112cellular response to reactive nitrogen species (GO:1902170)3.38147104
113L-fucose catabolic process (GO:0042355)3.36620174
114fucose catabolic process (GO:0019317)3.36620174
115L-fucose metabolic process (GO:0042354)3.36620174
116transcytosis (GO:0045056)3.36350926
117renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.36262226
118phospholipid efflux (GO:0033700)3.35326792
119vitamin biosynthetic process (GO:0009110)3.33731828
120glutamine family amino acid biosynthetic process (GO:0009084)3.31961317
121phosphatidylcholine biosynthetic process (GO:0006656)3.31403252
122positive regulation of lipid catabolic process (GO:0050996)3.31257913
123positive regulation of lipoprotein lipase activity (GO:0051006)3.27949875
124positive regulation of triglyceride lipase activity (GO:0061365)3.27949875
125glucuronate metabolic process (GO:0019585)3.26713959
126uronic acid metabolic process (GO:0006063)3.26713959
127cobalamin metabolic process (GO:0009235)3.25956887
128regulation of cholesterol esterification (GO:0010872)3.25824867
129negative regulation of protein tyrosine kinase activity (GO:0061099)3.25637273
130digestive system process (GO:0022600)3.25509261
131* regulation of guanylate cyclase activity (GO:0031282)3.25072415
132ceramide catabolic process (GO:0046514)3.24466233
133glycosylceramide metabolic process (GO:0006677)3.23365202
134neurotransmitter catabolic process (GO:0042135)3.22707314
135sphingomyelin metabolic process (GO:0006684)3.20233854
136glycerol metabolic process (GO:0006071)3.20094920
137bile acid metabolic process (GO:0008206)3.19944401
138diol metabolic process (GO:0034311)3.19612114
139primary alcohol catabolic process (GO:0034310)3.18800717
140antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.18592803
141oxidative phosphorylation (GO:0006119)3.16871306
142regulation of cholesterol homeostasis (GO:2000188)3.15932782
143regulation of early endosome to late endosome transport (GO:2000641)3.14953814
144alkaloid metabolic process (GO:0009820)3.14876721
145sphingolipid catabolic process (GO:0030149)3.14492395
146ethanol metabolic process (GO:0006067)3.14355151
147hydrogen ion transmembrane transport (GO:1902600)3.14302519
148drug transport (GO:0015893)3.13619346
149positive regulation of respiratory burst (GO:0060267)3.13194013
150negative regulation of cholesterol transport (GO:0032375)3.12123286
151negative regulation of sterol transport (GO:0032372)3.12123286
152rRNA catabolic process (GO:0016075)3.11460238
153leukotriene metabolic process (GO:0006691)3.11146546
154arginine metabolic process (GO:0006525)3.09412745
155sexual reproduction (GO:0019953)3.06025119
156positive regulation of epidermal cell differentiation (GO:0045606)3.05830938
157phosphate ion transport (GO:0006817)3.05707598
158mRNA modification (GO:0016556)3.04863877
159antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.04241185
160membrane lipid catabolic process (GO:0046466)3.02397318
161quinone biosynthetic process (GO:1901663)3.00043459
162azole transport (GO:0045117)2.99541020
163exogenous drug catabolic process (GO:0042738)2.98642194
164hepatocyte apoptotic process (GO:0097284)2.90202076
165neurotransmitter metabolic process (GO:0042133)2.87599394
166regulation of prostaglandin secretion (GO:0032306)2.86211827
167drug catabolic process (GO:0042737)2.80391385
168purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.80023092
169purine nucleoside triphosphate biosynthetic process (GO:0009145)2.78262798
170embryonic digestive tract morphogenesis (GO:0048557)2.78069069
171positive regulation of pseudopodium assembly (GO:0031274)2.68040526
172negative regulation of protein autophosphorylation (GO:0031953)2.67360298
173epithelial structure maintenance (GO:0010669)2.65692386
174keratinocyte proliferation (GO:0043616)2.65068629
175embryonic camera-type eye morphogenesis (GO:0048596)2.64937253
176proton transport (GO:0015992)2.64732938
177keratinocyte development (GO:0003334)2.64530777
178angiotensin maturation (GO:0002003)10.9657643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.97993434
2CDX2_20551321_ChIP-Seq_CACO-2_Human3.86291195
3CDX2_19796622_ChIP-Seq_MESCs_Mouse3.52681335
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.30720086
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.08343356
6SRY_22984422_ChIP-ChIP_TESTIS_Rat3.01057182
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87256038
8SOX2_20726797_ChIP-Seq_SW620_Human2.71096984
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.60838035
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48480812
11ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.46010923
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.33056065
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.27146235
14* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.20121484
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.17193046
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.15918263
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.12584038
18GATA1_22025678_ChIP-Seq_K562_Human2.11337155
19* IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11292406
20BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.11282042
21* GATA4_25053715_ChIP-Seq_YYC3_Human2.04393777
22* GATA6_25053715_ChIP-Seq_YYC3_Human2.02438066
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99713149
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.99461083
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94398482
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90989448
27* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89944582
28FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86978024
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84118299
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78358245
31KLF5_25053715_ChIP-Seq_YYC3_Human1.77736061
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74950420
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.71193505
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.68602497
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.62989311
36* RACK7_27058665_Chip-Seq_MCF-7_Human1.62490923
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59029894
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57021196
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51320166
40* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.48726683
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48185495
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46136776
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45934569
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45643311
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44955572
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43965439
47SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.43863717
48EGR1_19032775_ChIP-ChIP_M12_Human1.43389586
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.42219409
50DROSHA_22980978_ChIP-Seq_HELA_Human1.39165866
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36113640
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34690150
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.34363679
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.33226469
55HNF4A_19822575_ChIP-Seq_HepG2_Human1.31247014
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29913948
57CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.28592537
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.28308191
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27228955
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26570301
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.22260934
62CDX2_22108803_ChIP-Seq_LS180_Human1.22132658
63BCL6_27268052_Chip-Seq_Bcells_Human1.21421118
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21406927
65MYC_19915707_ChIP-ChIP_AK7_Human1.20361135
66ATF3_27146783_Chip-Seq_COLON_Human1.19922462
67* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19783822
68BCOR_27268052_Chip-Seq_Bcells_Human1.19624052
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19382797
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18489486
71JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.16594226
72RUNX1_27514584_Chip-Seq_MCF-7_Human1.15115094
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14213047
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13937715
75* FOXA1_25552417_ChIP-Seq_VCAP_Human1.12852589
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11753342
77OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11329156
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.09638192
79* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09035574
80* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08831070
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08490257
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.07143451
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05756900
84CTCF_20526341_ChIP-Seq_ESCs_Human1.04089102
85* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04042379
86SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02919793
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01988613
88* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01578557
89* LXR_22292898_ChIP-Seq_THP-1_Human1.01242601
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00792316
91* SA1_27219007_Chip-Seq_Bcells_Human1.00251742
92SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00202350
93* CTCF_27219007_Chip-Seq_Bcells_Human0.99962879
94NANOG_20526341_ChIP-Seq_ESCs_Human0.99663075
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99644402
96* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99250319
97ZNF263_19887448_ChIP-Seq_K562_Human0.98466395
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98323866
99GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98189652
100CLOCK_20551151_ChIP-Seq_293T_Human0.97866636
101AR_21909140_ChIP-Seq_LNCAP_Human0.97161250
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96405401
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96405401
104TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96291538
105STAT1_20625510_ChIP-Seq_HELA_Human0.95921244
106FOXA2_19822575_ChIP-Seq_HepG2_Human0.94662904
107CEBPB_22108803_ChIP-Seq_LS180_Human0.94578053
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94015953
109TAF2_19829295_ChIP-Seq_ESCs_Human0.93749940
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92576684
111VDR_22108803_ChIP-Seq_LS180_Human0.92440252
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91494327
113GATA1_19941826_ChIP-Seq_K562_Human0.91191229
114EZH2_27294783_Chip-Seq_ESCs_Mouse0.91180696
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90769759
116RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89280638
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89053497
118SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87834531
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87094109
120SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87069512
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86677317
122GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86500347
123CREB1_26743006_Chip-Seq_LNCaP_Human0.86466155
124GATA2_19941826_ChIP-Seq_K562_Human0.85248703
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.84737479
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83329631
127* VDR_24763502_ChIP-Seq_THP-1_Human0.83141171
128ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82917965
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82832094
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82832094
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82782369
132TET1_21451524_ChIP-Seq_MESCs_Mouse0.81531235
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80859279
134* TP63_22573176_ChIP-Seq_HFKS_Human0.80604826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy7.80157239
2MP0003283_abnormal_digestive_organ7.18810135
3MP0003878_abnormal_ear_physiology6.53814912
4MP0005377_hearing/vestibular/ear_phenot6.53814912
5MP0010234_abnormal_vibrissa_follicle5.17249761
6MP0003183_abnormal_peptide_metabolism4.30519923
7MP0009379_abnormal_foot_pigmentation3.85711599
8MP0005167_abnormal_blood-brain_barrier3.52474908
9MP0000462_abnormal_digestive_system3.49992824
10MP0004147_increased_porphyrin_level3.49287629
11MP0009840_abnormal_foam_cell3.46596087
12MP0008875_abnormal_xenobiotic_pharmacok3.13458189
13MP0003866_abnormal_defecation2.90063174
14MP0001873_stomach_inflammation2.67913903
15MP0003191_abnormal_cellular_cholesterol2.50383351
16MP0005381_digestive/alimentary_phenotyp2.44509071
17MP0001663_abnormal_digestive_system2.33481636
18MP0004264_abnormal_extraembryonic_tissu2.27615881
19MP0001666_abnormal_nutrient_absorption2.20122006
20MP0005409_darkened_coat_color2.14261553
21MP0005360_urolithiasis2.03434649
22* MP0010155_abnormal_intestine_physiology1.92144549
23MP0005332_abnormal_amino_acid1.81090451
24MP0005085_abnormal_gallbladder_physiolo1.81070902
25MP0004043_abnormal_pH_regulation1.78688137
26MP0003941_abnormal_skin_development1.75454845
27MP0003879_abnormal_hair_cell1.73534816
28* MP0000477_abnormal_intestine_morphology1.68348283
29MP0005670_abnormal_white_adipose1.57011896
30MP0009384_cardiac_valve_regurgitation1.50577253
31MP0002796_impaired_skin_barrier1.48290809
32MP0001188_hyperpigmentation1.44597362
33MP0001764_abnormal_homeostasis1.41475184
34MP0001664_abnormal_digestion1.37108002
35MP0000537_abnormal_urethra_morphology1.33878538
36MP0003806_abnormal_nucleotide_metabolis1.28536519
37MP0005365_abnormal_bile_salt1.26766593
38MP0003300_gastrointestinal_ulcer1.25923701
39MP0002139_abnormal_hepatobiliary_system1.23561567
40MP0003718_maternal_effect1.23058882
41MP0002234_abnormal_pharynx_morphology1.22393757
42MP0003315_abnormal_perineum_morphology1.22382256
43MP0001765_abnormal_ion_homeostasis1.19819267
44MP0004019_abnormal_vitamin_homeostasis1.13155079
45MP0010352_gastrointestinal_tract_polyps1.11244721
46MP0002876_abnormal_thyroid_physiology1.11216910
47* MP0000490_abnormal_crypts_of1.10400366
48MP0009643_abnormal_urine_homeostasis1.08237755
49MP0005166_decreased_susceptibility_to1.06526799
50MP0004885_abnormal_endolymph1.05706601
51MP0004270_analgesia1.03903864
52MP0003303_peritoneal_inflammation1.01123709
53MP0005451_abnormal_body_composition1.00744686
54MP0005448_abnormal_energy_balance1.00466320
55MP0003705_abnormal_hypodermis_morpholog0.99192382
56MP0004484_altered_response_of0.98773465
57MP0005310_abnormal_salivary_gland0.97067611
58MP0005535_abnormal_body_temperature0.94767711
59MP0002971_abnormal_brown_adipose0.94541292
60MP0000230_abnormal_systemic_arterial0.93651886
61MP0001849_ear_inflammation0.90105432
62MP0001501_abnormal_sleep_pattern0.89207450
63MP0010030_abnormal_orbit_morphology0.87701608
64MP0009785_altered_susceptibility_to0.86236186
65MP0000467_abnormal_esophagus_morphology0.81869158
66MP0005636_abnormal_mineral_homeostasis0.81830352
67MP0000470_abnormal_stomach_morphology0.81292230
68MP0009115_abnormal_fat_cell0.79433273
69MP0003724_increased_susceptibility_to0.77868793
70MP0001440_abnormal_grooming_behavior0.77326542
71MP0004185_abnormal_adipocyte_glucose0.77238832
72MP0002060_abnormal_skin_morphology0.76598764
73MP0003868_abnormal_feces_composition0.76501742
74MP0004782_abnormal_surfactant_physiolog0.76100372
75MP0005319_abnormal_enzyme/_coenzyme0.75780559
76MP0008873_increased_physiological_sensi0.75725697
77MP0002166_altered_tumor_susceptibility0.74939183
78MP0003252_abnormal_bile_duct0.73750420
79MP0002396_abnormal_hematopoietic_system0.72846922
80MP0010678_abnormal_skin_adnexa0.71637369
81MP0000762_abnormal_tongue_morphology0.71258713
82MP0000465_gastrointestinal_hemorrhage0.71221036
83MP0005084_abnormal_gallbladder_morpholo0.70286445
84MP0009642_abnormal_blood_homeostasis0.69275739
85MP0008469_abnormal_protein_level0.69090880
86MP0005666_abnormal_adipose_tissue0.68372434
87MP0002909_abnormal_adrenal_gland0.67790858
88MP0002277_abnormal_respiratory_mucosa0.67739316
89MP0004947_skin_inflammation0.67311038
90MP0003453_abnormal_keratinocyte_physiol0.66452733
91MP0003075_altered_response_to0.65652280
92MP0005386_behavior/neurological_phenoty0.62910705
93MP0004924_abnormal_behavior0.62910705
94MP0000538_abnormal_urinary_bladder0.62660685
95MP0005025_abnormal_response_to0.62599069
96MP0001485_abnormal_pinna_reflex0.62529612
97MP0008872_abnormal_physiological_respon0.61823575
98MP0000249_abnormal_blood_vessel0.59632642
99MP0002118_abnormal_lipid_homeostasis0.58295609
100MP0005501_abnormal_skin_physiology0.57136312
101MP0009764_decreased_sensitivity_to0.56778384
102MP0003436_decreased_susceptibility_to0.56123611
103MP0002138_abnormal_hepatobiliary_system0.55916501
104MP0001835_abnormal_antigen_presentation0.55794015
105MP0010329_abnormal_lipoprotein_level0.53980157
106MP0001529_abnormal_vocalization0.53718097
107MP0005584_abnormal_enzyme/coenzyme_acti0.53469318
108MP0005334_abnormal_fat_pad0.52966810
109MP0000678_abnormal_parathyroid_gland0.52683731
110MP0006082_CNS_inflammation0.52676195
111MP0002896_abnormal_bone_mineralization0.52618150
112MP0009333_abnormal_splenocyte_physiolog0.51627849
113MP0001790_abnormal_immune_system0.51543782
114MP0005387_immune_system_phenotype0.51543782
115MP0005174_abnormal_tail_pigmentation0.51137095
116MP0003953_abnormal_hormone_level0.49193423
117MP0000516_abnormal_urinary_system0.48818479
118MP0005367_renal/urinary_system_phenotyp0.48818479
119MP0002078_abnormal_glucose_homeostasis0.48475598
120MP0005165_increased_susceptibility_to0.48438990
121MP0003638_abnormal_response/metabolism_0.48418763
122MP0001216_abnormal_epidermal_layer0.48094054
123MP0005058_abnormal_lysosome_morphology0.47474486
124MP0006138_congestive_heart_failure0.46559495
125MP0009780_abnormal_chondrocyte_physiolo0.46240587
126MP0000604_amyloidosis0.46029900
127MP0001756_abnormal_urination0.45929194
128MP0002148_abnormal_hypersensitivity_rea0.45834997
129MP0000163_abnormal_cartilage_morphology0.45576220
130MP0002736_abnormal_nociception_after0.45555105
131MP0001963_abnormal_hearing_physiology0.43271232
132MP0002006_tumorigenesis0.43226756
133MP0000609_abnormal_liver_physiology0.42713640
134MP0000613_abnormal_salivary_gland0.41997572
135MP0010771_integument_phenotype0.40439866
136MP0009053_abnormal_anal_canal0.38976801
137MP0001845_abnormal_inflammatory_respons0.38954171
138MP0005266_abnormal_metabolism0.38280028
139MP0002136_abnormal_kidney_physiology0.36789523
140MP0004858_abnormal_nervous_system0.36700967
141MP0002098_abnormal_vibrissa_morphology0.36017749
142MP0002132_abnormal_respiratory_system0.35946354
143MP0000013_abnormal_adipose_tissue0.33427231

Predicted human phenotypes

RankGene SetZ-score
1Flat acetabular roof (HP:0003180)7.13929476
2Hydroxyprolinuria (HP:0003080)7.07275820
3Abnormality of proline metabolism (HP:0010907)7.07275820
4Pustule (HP:0200039)6.89069499
5Abnormality of the 1st metacarpal (HP:0010009)6.85184842
6Abnormality of the distal phalanx of the thumb (HP:0009617)5.75348487
7Abnormality of the vitamin B12 metabolism (HP:0004341)5.41361974
8Cupped ribs (HP:0000887)5.19482803
9Hypobetalipoproteinemia (HP:0003563)5.06672146
10Abnormality of vitamin B metabolism (HP:0004340)5.05851187
11Abnormality of carpal bone ossification (HP:0006257)5.05780139
12Symphalangism affecting the phalanges of the hand (HP:0009773)5.00555884
13Short phalanx of the thumb (HP:0009660)4.97456525
14Confusion (HP:0001289)4.62729806
15Abnormal tarsal ossification (HP:0008369)4.61905068
16Widely patent fontanelles and sutures (HP:0004492)4.57440730
17Fat malabsorption (HP:0002630)4.48718043
18Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)4.42397853
19Abnormality of the phalanges of the hallux (HP:0010057)4.41346056
20Abnormality of the proximal phalanges of the hand (HP:0009834)4.27468850
21Abnormality of the 2nd finger (HP:0004100)4.27413070
22Acanthocytosis (HP:0001927)4.20924475
23Alopecia of scalp (HP:0002293)4.14526267
24Neonatal short-limb short stature (HP:0008921)4.05386712
25Abnormality of vitamin metabolism (HP:0100508)4.00631261
26Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.00011406
27Abnormal ossification of hand bones (HP:0005921)3.92693663
28Flattened epiphyses (HP:0003071)3.81227092
29Abnormal hand bone ossification (HP:0010660)3.80883565
30Hyperglycinuria (HP:0003108)3.77502842
31Nausea (HP:0002018)3.76840793
32Right ventricular cardiomyopathy (HP:0011663)3.73911228
33Systemic lupus erythematosus (HP:0002725)3.70464414
34Alkalosis (HP:0001948)3.55929021
35Abnormality of urine glucose concentration (HP:0011016)3.54677212
36Glycosuria (HP:0003076)3.54677212
37Thin bony cortex (HP:0002753)3.53805609
38Abdominal distention (HP:0003270)3.51755706
39Abnormality of the middle phalanges of the toes (HP:0010183)3.50661821
40Proximal tubulopathy (HP:0000114)3.49258983
41Aplasia/hypoplasia of the femur (HP:0005613)3.48086357
42Pigmentary retinal degeneration (HP:0001146)3.47118601
43Flat capital femoral epiphysis (HP:0003370)3.42912817
44Wide cranial sutures (HP:0010537)3.42185071
45Short middle phalanx of finger (HP:0005819)3.33899024
46Absent phalangeal crease (HP:0006109)3.33471530
47Metabolic alkalosis (HP:0200114)3.31816117
48Short hallux (HP:0010109)3.30196416
49Abnormality of serine family amino acid metabolism (HP:0010894)3.21880387
50Abnormality of glycine metabolism (HP:0010895)3.21880387
51Ileus (HP:0002595)3.16594275
52Nephrolithiasis (HP:0000787)3.16413165
53Abnormal foot bone ossification (HP:0010675)3.09279818
54Xanthomatosis (HP:0000991)3.08023291
55Irregular epiphyses (HP:0010582)3.06742124
56Hyperuricemia (HP:0002149)3.06349393
57Increased purine levels (HP:0004368)3.06349393
58Hyperactive renin-angiotensin system (HP:0000841)3.05916179
59Acute necrotizing encephalopathy (HP:0006965)3.03107533
60Megaloblastic anemia (HP:0001889)2.99798494
61Aplasia/Hypoplasia of the hallux (HP:0008362)2.98379863
62Abnormality of monocarboxylic acid metabolism (HP:0010996)2.98012582
63Relative macrocephaly (HP:0004482)2.97329484
64Breech presentation (HP:0001623)2.89674696
65Potter facies (HP:0002009)2.85805607
66Facial shape deformation (HP:0011334)2.85805607
67Hypophosphatemia (HP:0002148)2.85430921
68Posterior subcapsular cataract (HP:0007787)2.83769033
69Cheilitis (HP:0100825)2.83649946
70Steatorrhea (HP:0002570)2.83347223
71Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.83249652
72Hyperparathyroidism (HP:0000843)2.81492755
73Acute encephalopathy (HP:0006846)2.79004262
74Vertebral clefting (HP:0008428)2.77432860
75Abnormal cartilage morphology (HP:0002763)2.75780506
76Abnormal mitochondria in muscle tissue (HP:0008316)2.74922184
77Flared iliac wings (HP:0002869)2.74143648
78Short tibia (HP:0005736)2.73521666
79Abnormal finger flexion creases (HP:0006143)2.72008487
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.64912564
81Septate vagina (HP:0001153)2.63295370
82Abnormality of purine metabolism (HP:0004352)2.62799509
83Spinal cord compression (HP:0002176)2.61673288
84Hyperammonemia (HP:0001987)2.61335385
85Short femoral neck (HP:0100864)2.60463163
86Large earlobe (HP:0009748)2.60133594
87Eczematoid dermatitis (HP:0000976)2.59876450
88Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.58554530
89Vertebral hypoplasia (HP:0008417)2.58554530
90Enlarged epiphyses (HP:0010580)2.56047237
91Abnormal urine phosphate concentration (HP:0012599)2.55713605
92Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.54477886
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51797351
94Dicarboxylic aciduria (HP:0003215)2.51797351
95Hypolipoproteinemia (HP:0010981)2.51767386
96Short 1st metacarpal (HP:0010034)2.49755766
97Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.49755766
98Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49657207
99Progressive macrocephaly (HP:0004481)2.48010674
100Hypotension (HP:0002615)2.45419957
101Abnormal vertebral ossification (HP:0100569)2.45361997
102Delayed epiphyseal ossification (HP:0002663)2.44720101
103Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.44328148
104Hemorrhage of the eye (HP:0011885)2.42270350
105Hyperphosphaturia (HP:0003109)2.41640929
106Focal segmental glomerulosclerosis (HP:0000097)2.39464514
107Lumbar hyperlordosis (HP:0002938)2.35968733
108Abnormality of nucleobase metabolism (HP:0010932)2.34247885
109Coxa vara (HP:0002812)2.32863661
110Petechiae (HP:0000967)2.31862860
111Genu varum (HP:0002970)2.30688584
112Aplasia/Hypoplasia of the tibia (HP:0005772)2.29550138
113Abnormality of the costochondral junction (HP:0000919)2.29169337
114Renal tubular acidosis (HP:0001947)2.29130049
115Ovoid vertebral bodies (HP:0003300)2.25173357
116Metabolic acidosis (HP:0001942)2.23974069
117Abnormality of the epiphysis of the femoral head (HP:0010574)2.22275821
118Hip contracture (HP:0003273)2.22275335
119Villous atrophy (HP:0011473)2.21801035
120Abnormality of small intestinal villus morphology (HP:0011472)2.21801035
121Sandal gap (HP:0001852)2.21493318
122Protuberant abdomen (HP:0001538)2.18786572
123Hoarse voice (HP:0001609)2.16916071
124Gout (HP:0001997)2.16096946
125Abnormality of renin-angiotensin system (HP:0000847)2.15246970
126Abnormality of the femoral head (HP:0003368)2.14952198
127Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.14154831
128Broad palm (HP:0001169)2.12801424
129Fragile nails (HP:0001808)2.12054883
130Abnormality of magnesium homeostasis (HP:0004921)2.10106829
131Cerebral palsy (HP:0100021)2.09379133
132Hyperaldosteronism (HP:0000859)2.08346625
133Hyperphosphatemia (HP:0002905)2.07744963
134Subcapsular cataract (HP:0000523)2.07279927
135Ridged nail (HP:0001807)2.06626744
136Abnormality of chloride homeostasis (HP:0011422)2.05949185
137Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.05527449
138Abnormality of femoral epiphyses (HP:0006499)2.05527449
139Epidermoid cyst (HP:0200040)2.04160125
140Hypokalemia (HP:0002900)2.03494486
141Short humerus (HP:0005792)2.02813344
142Malnutrition (HP:0004395)2.01862461
143Abnormality of the middle phalanges of the hand (HP:0009833)2.01650218
144Pancreatitis (HP:0001733)2.01018448
145Abnormal glucose tolerance (HP:0001952)2.00064704
146Abnormality of glutamine family amino acid metabolism (HP:0010902)10.1887336
147Chronic diarrhea (HP:0002028)1.99774699
148Growth hormone excess (HP:0000845)1.99657000
149Fragile skin (HP:0001030)1.97691835
150Gastrointestinal dysmotility (HP:0002579)1.97619047
151Cerebral edema (HP:0002181)1.95553439
152Hypoplastic ilia (HP:0000946)1.95027003
153Gingivitis (HP:0000230)1.93365771
154Bundle branch block (HP:0011710)1.93355393
155Mitochondrial inheritance (HP:0001427)1.90651747
156Decreased circulating renin level (HP:0003351)1.90161755
157Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.88269705
158Multiple lipomas (HP:0001012)1.87578925
159Renal tubular dysfunction (HP:0000124)1.87281632
160Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85737572
161Intrahepatic cholestasis (HP:0001406)1.84856925
162Irritability (HP:0000737)1.83876716
163Pili torti (HP:0003777)1.83493627
164Tracheal stenosis (HP:0002777)1.83475212
165Congenital sensorineural hearing impairment (HP:0008527)1.83118778
166Abnormality of sulfur amino acid metabolism (HP:0004339)1.83022960
167Dehydration (HP:0001944)1.82458795
168Visceral angiomatosis (HP:0100761)1.82250202
169Myokymia (HP:0002411)1.81832022
170Palpitations (HP:0001962)1.80103056
171Glomerulonephritis (HP:0000099)1.78169996
172Poikilocytosis (HP:0004447)1.77867995
173Glomerulosclerosis (HP:0000096)1.77298314
174Woolly hair (HP:0002224)1.77287823
175Vaginal fistula (HP:0004320)1.75982351
176Abnormality of potassium homeostasis (HP:0011042)1.73835552
177Symptomatic seizures (HP:0011145)1.73529366
178Abnormality of alkaline phosphatase activity (HP:0004379)1.72461875
179Conjugated hyperbilirubinemia (HP:0002908)1.72431367
180Abnormal enzyme/coenzyme activity (HP:0012379)1.72393887
181Abnormality of pyrimidine metabolism (HP:0004353)1.71953433
182Abnormal biliary tract morphology (HP:0012440)1.69484928
183Segmental peripheral demyelination/remyelination (HP:0003481)1.69189654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA8.78490388
2ACVR1B8.49637578
3MST1R7.63800991
4MAP2K23.64385552
5EPHA23.54419516
6MAP3K103.12188604
7DDR22.90333464
8TAOK32.65998601
9EPHB22.59882695
10MET2.57301106
11PRKG22.25623478
12MATK2.11962757
13MAP3K122.11345317
14LMTK22.09512346
15MYLK1.95925912
16STK391.91756395
17TESK11.91451260
18CAMK2D1.89035450
19MAP3K21.69920014
20PDK21.59266643
21OXSR11.56974876
22FGFR41.55434049
23FRK1.52428806
24TYK21.46388613
25KSR21.37744374
26LIMK11.32742631
27BRAF1.32096537
28EPHA31.30835486
29MAP4K11.28219488
30RIPK41.26037962
31CDK31.23222259
32STK241.22546561
33EPHA41.20367126
34MAP2K11.17809483
35GRK61.12070959
36CSK1.07001160
37PRPF4B1.05466632
38TYRO31.02904596
39AKT31.02093640
40CAMK1D0.96677334
41TAOK10.93385512
42CDC42BPA0.92864103
43DAPK30.92461492
44RIPK10.88300993
45CAMK2B0.87583260
46TTK0.83741992
47FGFR30.82674544
48PDPK10.77725284
49PTK60.76533780
50CAMK2G0.76523040
51MAPKAPK50.73873220
52NEK10.73570037
53MAP2K60.73472064
54NLK0.72334494
55WNK40.71504891
56MAP3K80.69578965
57CDK150.69483661
58FGR0.65780384
59PIM10.65547340
60DYRK1B0.65002022
61MAPK110.64881258
62PDGFRA0.64618524
63CDK180.64342689
64CDK11A0.60954576
65MST40.60221434
66PDK10.59785086
67MAP3K10.59703493
68ICK0.57336802
69TBK10.57191729
70DMPK0.56495345
71CDK90.56126525
72PAK40.55812392
73PRKCZ0.53995711
74TESK20.52178153
75ERN10.52169500
76KDR0.50559733
77PRKCA0.50498091
78CDK190.50436389
79CDK140.50113557
80BMPR20.47994470
81CAMK1G0.47817053
82PIM20.43468292
83EPHB10.43437140
84CASK0.42487714
85IRAK10.42311884
86RPS6KB20.41953471
87ERBB20.41900499
88NME10.41584900
89MAP3K30.41316037
90WNK10.40305097
91SRC0.39987844
92RET0.38829973
93ROCK10.38070205
94LYN0.37525413
95JAK20.36929809
96TTN0.36825456
97MAP3K90.36029292
98FYN0.34909007
99ALK0.34830456
100PRKCI0.34722808
101IKBKE0.34422603
102BMX0.32283533
103JAK10.32274449
104CSF1R0.31844131
105PIK3CG0.31231382
106GRK10.31080357
107AURKB0.30952775
108TNIK0.29873741
109TRIB30.28975140
110PTK20.28562698
111SMG10.28248674
112BTK0.28021947
113ZAP700.27543541
114CDK60.27379169
115PRKG10.27259698
116YES10.27005754
117FER0.26749817
118SYK0.26479658
119ABL20.26416269
120RPS6KA20.26289174
121DAPK20.26089806
122ITK0.25418075
123PRKACG0.25219017
124PAK10.25085241
125CAMK2A0.23106873
126PRKCD0.22986534
127MAPKAPK20.22855264
128STK110.22474808
129PRKD20.22350830
130NEK60.22344524
131PDGFRB0.22234080
132TEC0.22043756
133CDK50.20843474
134MAP3K140.19852556
135MAPK40.19044008
136PRKCQ0.17804550
137AKT20.17518961
138CSNK1A10.16994820
139MELK0.16601742
140PAK20.15492894
141PRKCH0.15206341
142PRKCE0.14701216
143PRKAA20.13279030
144BCKDK0.13226270
145PTK2B0.12641693
146PRKACB0.11384470
147PRKCB0.10957277
148MAP3K110.10823105

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009209.17976163
2Cyanoamino acid metabolism_Homo sapiens_hsa004605.17403260
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.07306798
4Vitamin digestion and absorption_Homo sapiens_hsa049774.59441184
5Sulfur relay system_Homo sapiens_hsa041223.82378965
6Mineral absorption_Homo sapiens_hsa049782.79768432
7Oxidative phosphorylation_Homo sapiens_hsa001902.79041457
8Butanoate metabolism_Homo sapiens_hsa006502.61824445
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.46426488
10Parkinsons disease_Homo sapiens_hsa050122.35712143
11Arginine biosynthesis_Homo sapiens_hsa002202.17492280
12Alzheimers disease_Homo sapiens_hsa050102.03224010
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.88895816
14Histidine metabolism_Homo sapiens_hsa003401.82298434
15Cardiac muscle contraction_Homo sapiens_hsa042601.70690680
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69488748
17Bile secretion_Homo sapiens_hsa049761.63986735
18Fat digestion and absorption_Homo sapiens_hsa049751.59731485
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54780018
20Fructose and mannose metabolism_Homo sapiens_hsa000511.53414070
21Huntingtons disease_Homo sapiens_hsa050161.37717392
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37568287
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33275937
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27751883
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24940898
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22797164
27Linoleic acid metabolism_Homo sapiens_hsa005911.18076131
28Tryptophan metabolism_Homo sapiens_hsa003801.13198974
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12957008
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12444885
31Chemical carcinogenesis_Homo sapiens_hsa052041.10857565
32Asthma_Homo sapiens_hsa053101.09809437
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.07756284
34Salivary secretion_Homo sapiens_hsa049701.04547212
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03781784
36Pancreatic secretion_Homo sapiens_hsa049720.98662766
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97772812
38Fatty acid degradation_Homo sapiens_hsa000710.96685937
39Galactose metabolism_Homo sapiens_hsa000520.96382870
40Phenylalanine metabolism_Homo sapiens_hsa003600.94891878
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91968937
42PPAR signaling pathway_Homo sapiens_hsa033200.87777154
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86796900
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.83497717
45Tight junction_Homo sapiens_hsa045300.82752576
46ABC transporters_Homo sapiens_hsa020100.77490149
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76975555
48Allograft rejection_Homo sapiens_hsa053300.76519719
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73951791
50Autoimmune thyroid disease_Homo sapiens_hsa053200.71154351
51Bladder cancer_Homo sapiens_hsa052190.69793041
52Graft-versus-host disease_Homo sapiens_hsa053320.67123319
53Thyroid cancer_Homo sapiens_hsa052160.66557720
54Folate biosynthesis_Homo sapiens_hsa007900.64849822
55Glycerolipid metabolism_Homo sapiens_hsa005610.62652177
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62626099
57African trypanosomiasis_Homo sapiens_hsa051430.61600027
58Salmonella infection_Homo sapiens_hsa051320.61088773
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.57535422
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57245586
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.53656191
62Starch and sucrose metabolism_Homo sapiens_hsa005000.52455558
63Staphylococcus aureus infection_Homo sapiens_hsa051500.51224873
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49936435
65Type I diabetes mellitus_Homo sapiens_hsa049400.49678753
66Other glycan degradation_Homo sapiens_hsa005110.47536920
67Propanoate metabolism_Homo sapiens_hsa006400.44825059
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.44622824
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43690439
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.43620701
71Gastric acid secretion_Homo sapiens_hsa049710.43084521
72Metabolic pathways_Homo sapiens_hsa011000.42440766
73Renin secretion_Homo sapiens_hsa049240.42205869
74Ether lipid metabolism_Homo sapiens_hsa005650.41689640
75Carbon metabolism_Homo sapiens_hsa012000.40354330
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.39915108
77Arachidonic acid metabolism_Homo sapiens_hsa005900.39478102
78Glutathione metabolism_Homo sapiens_hsa004800.39171825
79Gap junction_Homo sapiens_hsa045400.37967695
80Tyrosine metabolism_Homo sapiens_hsa003500.37685989
81Fatty acid metabolism_Homo sapiens_hsa012120.36450850
82Pyruvate metabolism_Homo sapiens_hsa006200.34486861
83Insulin resistance_Homo sapiens_hsa049310.32817741
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31978309
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.31513150
86Fatty acid biosynthesis_Homo sapiens_hsa000610.31488126
87Nitrogen metabolism_Homo sapiens_hsa009100.30964970
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30924730
89Pentose phosphate pathway_Homo sapiens_hsa000300.30894827
90Antigen processing and presentation_Homo sapiens_hsa046120.30275586
91beta-Alanine metabolism_Homo sapiens_hsa004100.30151537
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30079280
93Sphingolipid metabolism_Homo sapiens_hsa006000.24860126
94GnRH signaling pathway_Homo sapiens_hsa049120.24258924
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24158134
96Hepatitis C_Homo sapiens_hsa051600.23339772
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23244480
98Biosynthesis of amino acids_Homo sapiens_hsa012300.22902430
99Protein digestion and absorption_Homo sapiens_hsa049740.22547790
100Leishmaniasis_Homo sapiens_hsa051400.21496878
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.21073542
102Arginine and proline metabolism_Homo sapiens_hsa003300.20999621
103Retinol metabolism_Homo sapiens_hsa008300.18858593
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18081268
105Caffeine metabolism_Homo sapiens_hsa002320.16818055
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16544986
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16098591
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16075829
109Insulin secretion_Homo sapiens_hsa049110.15863919
110Glucagon signaling pathway_Homo sapiens_hsa049220.15177237
111Cocaine addiction_Homo sapiens_hsa050300.11301221
112Viral myocarditis_Homo sapiens_hsa054160.10601337
113Peroxisome_Homo sapiens_hsa041460.09484782
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.07400176
115Pertussis_Homo sapiens_hsa051330.07311940
116Renin-angiotensin system_Homo sapiens_hsa046140.06952456
117Systemic lupus erythematosus_Homo sapiens_hsa053220.06917293
118Amphetamine addiction_Homo sapiens_hsa050310.06309526
119Thyroid hormone synthesis_Homo sapiens_hsa049180.06207366
120Prion diseases_Homo sapiens_hsa050200.05589472
121Fatty acid elongation_Homo sapiens_hsa000620.04916596
122Hematopoietic cell lineage_Homo sapiens_hsa046400.04590713
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.04384385
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.04280693
125VEGF signaling pathway_Homo sapiens_hsa043700.03351047
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.02968612
127Serotonergic synapse_Homo sapiens_hsa047260.02761285
128Estrogen signaling pathway_Homo sapiens_hsa049150.02406625
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.01953034
130Toxoplasmosis_Homo sapiens_hsa051450.01519163
131AMPK signaling pathway_Homo sapiens_hsa041520.01100734

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