GTPBP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GTP binding protein and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.81701636
2viral transcription (GO:0019083)5.88333796
3translational termination (GO:0006415)5.73196096
4translational elongation (GO:0006414)4.97950449
5formation of translation preinitiation complex (GO:0001731)4.89938967
6nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.85360607
7ribosomal small subunit assembly (GO:0000028)4.80086103
8translational initiation (GO:0006413)4.79443245
9ribosomal small subunit biogenesis (GO:0042274)4.77228683
10maturation of SSU-rRNA (GO:0030490)4.65285906
11mannose metabolic process (GO:0006013)4.58484146
12cellular protein complex disassembly (GO:0043624)4.55413366
13viral life cycle (GO:0019058)4.42745774
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.30272689
15peptidyl-arginine omega-N-methylation (GO:0035247)4.27710259
16protein targeting to ER (GO:0045047)4.22186431
17cotranslational protein targeting to membrane (GO:0006613)4.19919639
18protein complex disassembly (GO:0043241)4.16833109
19ribosomal large subunit biogenesis (GO:0042273)4.12852922
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.12132845
21positive regulation of protein homooligomerization (GO:0032464)4.06423230
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.02779026
23protein localization to endoplasmic reticulum (GO:0070972)3.98069463
24negative regulation of erythrocyte differentiation (GO:0045647)3.97872284
25regulation of translational fidelity (GO:0006450)3.94622276
26modulation by virus of host process (GO:0019054)3.92847308
27positive thymic T cell selection (GO:0045059)3.92840438
28ribonucleoprotein complex biogenesis (GO:0022613)3.92478158
29modulation by symbiont of host cellular process (GO:0044068)3.91501455
30histone arginine methylation (GO:0034969)3.88544990
31macromolecular complex disassembly (GO:0032984)3.88423258
32transcription from mitochondrial promoter (GO:0006390)3.80241817
33negative regulation of RNA splicing (GO:0033119)3.75755276
34negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.75061149
35ribosome biogenesis (GO:0042254)3.74221351
36proline biosynthetic process (GO:0006561)3.73908142
37thymic T cell selection (GO:0045061)3.71592879
38peptidyl-arginine methylation (GO:0018216)3.69580573
39peptidyl-arginine N-methylation (GO:0035246)3.69580573
40DNA damage response, detection of DNA damage (GO:0042769)3.69320945
41negative regulation of microtubule polymerization (GO:0031115)3.68240392
42negative regulation of mRNA processing (GO:0050686)3.64891037
43viral mRNA export from host cell nucleus (GO:0046784)3.57361489
44protein insertion into membrane (GO:0051205)3.55850786
45nuclear-transcribed mRNA catabolic process (GO:0000956)3.49254716
46positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.43539781
473-UTR-mediated mRNA stabilization (GO:0070935)3.41527974
48mitochondrial RNA metabolic process (GO:0000959)3.39180784
49mRNA catabolic process (GO:0006402)3.37825089
50rRNA processing (GO:0006364)3.37809452
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.36900375
52regulation of protein homooligomerization (GO:0032462)3.33840716
53dosage compensation (GO:0007549)3.33384128
54NIK/NF-kappaB signaling (GO:0038061)3.28685888
55activation of MAPKKK activity (GO:0000185)3.28017028
56RNA catabolic process (GO:0006401)3.26994543
57respiratory system process (GO:0003016)3.24844382
58regulation of mammary gland epithelial cell proliferation (GO:0033599)3.24549911
59regulation of gene silencing by RNA (GO:0060966)3.24429799
60regulation of posttranscriptional gene silencing (GO:0060147)3.24429799
61regulation of gene silencing by miRNA (GO:0060964)3.24429799
62rRNA metabolic process (GO:0016072)3.22736410
63translation (GO:0006412)3.21545731
64spliceosomal snRNP assembly (GO:0000387)3.21355655
65proteasome assembly (GO:0043248)3.20621017
66pinocytosis (GO:0006907)3.16253384
67DNA strand elongation involved in DNA replication (GO:0006271)3.15881677
68positive regulation of gamma-delta T cell activation (GO:0046645)3.15141408
69negative regulation of cell size (GO:0045792)3.14025073
70histone H4-K12 acetylation (GO:0043983)3.12997476
71cellular response to virus (GO:0098586)3.07733496
72antigen processing and presentation of endogenous antigen (GO:0019883)3.03188684
73modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.03101665
74positive regulation by organism of defense response of other organism involved in symbiotic interact3.03101665
75modulation by symbiont of host immune response (GO:0052553)3.03101665
76positive regulation by symbiont of host defense response (GO:0052509)3.03101665
77modulation by symbiont of host defense response (GO:0052031)3.03101665
78modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.03101665
79focal adhesion assembly (GO:0048041)3.02125856
80cell-substrate adherens junction assembly (GO:0007045)3.02125856
81DNA strand elongation (GO:0022616)3.01461549
82negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.00965682
83response to muramyl dipeptide (GO:0032495)3.00740432
84adherens junction assembly (GO:0034333)3.00424810
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98868976
86response to peptidoglycan (GO:0032494)2.98630284
87negative regulation of mRNA metabolic process (GO:1903312)2.98228038
88response to laminar fluid shear stress (GO:0034616)2.97979742
89GDP-mannose metabolic process (GO:0019673)2.95577365
90pseudouridine synthesis (GO:0001522)2.95548938
91pentose-phosphate shunt (GO:0006098)2.95323555
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93513077
93negative regulation of cell killing (GO:0031342)2.93513077
94cellular component biogenesis (GO:0044085)2.92963457
95protein localization to endosome (GO:0036010)2.87721176
96protein targeting to membrane (GO:0006612)2.85339789
97positive regulation of histone deacetylation (GO:0031065)2.84638442
98T cell selection (GO:0045058)2.84231088
99regulation of type I interferon-mediated signaling pathway (GO:0060338)2.83662489
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83549726
101regulation of early endosome to late endosome transport (GO:2000641)2.81534511
102epithelial cell differentiation involved in prostate gland development (GO:0060742)2.79751865
103positive regulation of T cell apoptotic process (GO:0070234)2.79470400
104DNA unwinding involved in DNA replication (GO:0006268)2.79116922
105intracellular estrogen receptor signaling pathway (GO:0030520)2.78592476
106positive regulation of Cdc42 GTPase activity (GO:0043089)2.77987535
107regulation of chromatin binding (GO:0035561)2.76205167
108tRNA methylation (GO:0030488)2.74916761
109regulation of gamma-delta T cell differentiation (GO:0045586)2.73373497
110mitochondrial DNA metabolic process (GO:0032042)2.73229473
111barbed-end actin filament capping (GO:0051016)2.73055197
112L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72016274
113apoptotic process involved in morphogenesis (GO:0060561)2.71973543
114glucose catabolic process (GO:0006007)2.71775576
115positive T cell selection (GO:0043368)2.69791867
116telomere maintenance via semi-conservative replication (GO:0032201)2.68119228
117maternal placenta development (GO:0001893)2.66391539
118pre-miRNA processing (GO:0031054)2.66195244
119modulation by virus of host morphology or physiology (GO:0019048)2.66079030
120regulation of translational termination (GO:0006449)2.65608094
121negative regulation of JAK-STAT cascade (GO:0046426)2.64442334
122regulation of protein heterodimerization activity (GO:0043497)2.64151528
123regulation of gamma-delta T cell activation (GO:0046643)2.63702812
124RNA splicing, via transesterification reactions (GO:0000375)2.63251354
125positive regulation of lymphocyte apoptotic process (GO:0070230)2.62788354
126mRNA splicing, via spliceosome (GO:0000398)2.62292992
127RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.62292992
128activation of JUN kinase activity (GO:0007257)2.62187274
129mitotic G1 DNA damage checkpoint (GO:0031571)2.61605871
130nodal signaling pathway (GO:0038092)2.60515847
131tRNA modification (GO:0006400)2.59347394
132ribosome assembly (GO:0042255)2.58228027
133positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.57505494
134positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.57263312
135positive regulation of protein dephosphorylation (GO:0035307)2.56893503
136termination of RNA polymerase II transcription (GO:0006369)2.56625227
137CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.55691667
138negative regulation of necroptotic process (GO:0060546)2.55110793
139positive regulation of B cell differentiation (GO:0045579)2.54968623
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54532683
141stress fiber assembly (GO:0043149)2.54222769
142creatine metabolic process (GO:0006600)2.54045631
143mitotic G1/S transition checkpoint (GO:0044819)2.53741800
144regulation of translational elongation (GO:0006448)2.53065932
145regulation of extracellular matrix disassembly (GO:0010715)2.52907515
146pteridine-containing compound biosynthetic process (GO:0042559)2.51804576
147ribonucleoprotein complex assembly (GO:0022618)2.49256153
148regulation of glucose import in response to insulin stimulus (GO:2001273)2.48788841
149mucosal-associated lymphoid tissue development (GO:0048537)2.48365007
150Peyers patch development (GO:0048541)2.48365007
151positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.48224831
152proline metabolic process (GO:0006560)2.48004407
153establishment of protein localization to mitochondrion (GO:0072655)2.47898297
154regulation of defense response to virus by virus (GO:0050690)2.47847308
155mitotic nuclear envelope reassembly (GO:0007084)2.47731824
156nuclear envelope reassembly (GO:0031468)2.47731824
157detection of bacterium (GO:0016045)2.46879520
158activation of Rac GTPase activity (GO:0032863)2.46735811
159folic acid-containing compound biosynthetic process (GO:0009396)2.46614909
160positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.46575522
161positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.45380337
162positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.44291961
163embryonic process involved in female pregnancy (GO:0060136)2.43869388
164signal complex assembly (GO:0007172)2.43680436
165exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43177110
166antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.42879105
167negative thymic T cell selection (GO:0045060)2.42573395
168positive regulation of myotube differentiation (GO:0010831)2.42524182
169cellular response to interleukin-4 (GO:0071353)2.42440530
170leukocyte aggregation (GO:0070486)2.42133144
171regulation of necrotic cell death (GO:0010939)2.42113145
172regulation of necroptotic process (GO:0060544)2.40731925
173germinal center formation (GO:0002467)2.39224337
174regulation of ARF GTPase activity (GO:0032312)2.36970876
175positive regulation of protein deacetylation (GO:0090312)2.36205455
176regulation of monocyte differentiation (GO:0045655)2.34933335
177B cell receptor signaling pathway (GO:0050853)2.34703269
178NADPH regeneration (GO:0006740)2.33899999
179UV protection (GO:0009650)2.33722462
180negative regulation of viral release from host cell (GO:1902187)2.33667556
181antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.32624570
182spliceosomal tri-snRNP complex assembly (GO:0000244)2.31127418
183detection of other organism (GO:0098543)2.28828012
184megakaryocyte development (GO:0035855)2.28639164
185lipopolysaccharide-mediated signaling pathway (GO:0031663)2.28636853
186planar cell polarity pathway involved in neural tube closure (GO:0090179)2.25816400
187NADH metabolic process (GO:0006734)2.25471240
188regulation of leukocyte degranulation (GO:0043300)2.25424132
189response to interleukin-4 (GO:0070670)2.25353750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.45874389
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44769649
3MYC_22102868_ChIP-Seq_BL_Human2.92094744
4E2F7_22180533_ChIP-Seq_HELA_Human2.77822606
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60141268
6VDR_21846776_ChIP-Seq_THP-1_Human2.58380278
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46822306
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.29970097
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25736394
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.25720376
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22540682
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19325030
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17170323
14XRN2_22483619_ChIP-Seq_HELA_Human2.13700765
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11347509
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10079117
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06598952
18YY1_21170310_ChIP-Seq_MESCs_Mouse2.05045376
19LXR_22292898_ChIP-Seq_THP-1_Human1.99463003
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94748616
21SRY_22984422_ChIP-ChIP_TESTIS_Rat1.90562671
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.88141289
23ZNF263_19887448_ChIP-Seq_K562_Human1.85266321
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78074651
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75285248
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71728706
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71482003
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.70739488
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68084755
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67487086
31* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.65808533
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.65382620
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63375271
34KDM2B_26808549_Chip-Seq_K562_Human1.58797620
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58037051
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.57886719
37GABP_19822575_ChIP-Seq_HepG2_Human1.56802151
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53953740
39CIITA_25753668_ChIP-Seq_RAJI_Human1.53406026
40* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53245178
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53173758
42SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.52353878
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52034632
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51677966
45VDR_23849224_ChIP-Seq_CD4+_Human1.51486143
46KDM2B_26808549_Chip-Seq_DND41_Human1.49848712
47* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48814126
48TTF2_22483619_ChIP-Seq_HELA_Human1.48507211
49* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47375286
50YY1_22570637_ChIP-Seq_MALME-3M_Human1.46796455
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.45526690
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45222804
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.44725483
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44520113
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44344751
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.42473014
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41053142
58SMC4_20622854_ChIP-Seq_HELA_Human1.38240843
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.37479426
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37375526
61* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36379619
62KDM5A_27292631_Chip-Seq_BREAST_Human1.36325394
63TCF7_22412390_ChIP-Seq_EML_Mouse1.35896249
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35881972
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35400971
66MAF_26560356_Chip-Seq_TH1_Human1.35391112
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34787414
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34787414
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34787414
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34228033
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33865384
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33828512
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.33264588
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33230095
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.33052495
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32620054
77CREB1_26743006_Chip-Seq_LNCaP_Human1.30594719
78FOXP1_21924763_ChIP-Seq_HESCs_Human1.30547033
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30277891
80UTX_26944678_Chip-Seq_JUKART_Human1.29516085
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29308213
82* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28879510
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28694925
84MAF_26560356_Chip-Seq_TH2_Human1.28408489
85DCP1A_22483619_ChIP-Seq_HELA_Human1.28050527
86FOXP3_21729870_ChIP-Seq_TREG_Human1.27480806
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26311452
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25488594
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24541243
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23661636
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.23601463
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23434233
93P68_20966046_ChIP-Seq_HELA_Human1.23356665
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22713280
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22576263
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.22396846
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22169464
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21639229
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21598497
100OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20014910
101NCOR1_26117541_ChIP-Seq_K562_Human1.19961825
102* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19891015
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19409581
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19325006
105SCL_19346495_ChIP-Seq_HPC-7_Human1.16463536
106* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16241772
107RACK7_27058665_Chip-Seq_MCF-7_Human1.16181449
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15932399
109VDR_24763502_ChIP-Seq_THP-1_Human1.15281177
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15230403
111CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14943916
112CTCF_26484167_Chip-Seq_Bcells_Mouse1.14437274
113BCL6_27268052_Chip-Seq_Bcells_Human1.14355670
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14015001
115CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13927511
116GATA1_19941827_ChIP-Seq_MEL_Mouse1.13879274
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13189511
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12894976
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12882697
120EGR1_19374776_ChIP-ChIP_THP-1_Human1.11190096
121BCOR_27268052_Chip-Seq_Bcells_Human1.10906928
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10503670
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09858763
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09356285
125TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08538708
126SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08283757
127ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08074459
128E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08008437
129P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07351936
130CTCF_27219007_Chip-Seq_Bcells_Human1.07044441
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06554510
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06469905
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06185464
134CTCF_21964334_Chip-Seq_Bcells_Human1.05939845
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05325391
136STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03888940
137TFEB_21752829_ChIP-Seq_HELA_Human1.03614187
138NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03148605
139PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02755707
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02319090
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02272100
142MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01810052
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01158377
144MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01112497
145MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01017527
146CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00590943
147ATF3_27146783_Chip-Seq_COLON_Human1.00433730
148TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00302054
149CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99472405
150GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98951177
151PHF8_20622854_ChIP-Seq_HELA_Human0.98494769
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97820236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.82652868
2MP0003705_abnormal_hypodermis_morpholog3.40339364
3MP0002653_abnormal_ependyma_morphology3.40099595
4MP0005451_abnormal_body_composition3.06921419
5MP0005058_abnormal_lysosome_morphology2.99131758
6MP0009278_abnormal_bone_marrow2.73161628
7MP0010352_gastrointestinal_tract_polyps2.68916176
8MP0004957_abnormal_blastocyst_morpholog2.58016394
9MP0000685_abnormal_immune_system2.53731332
10MP0008057_abnormal_DNA_replication2.51578517
11MP0003111_abnormal_nucleus_morphology2.47285338
12MP0004185_abnormal_adipocyte_glucose2.33860024
13MP0009840_abnormal_foam_cell2.32994315
14MP0008260_abnormal_autophagy2.32265742
15MP0004133_heterotaxia2.31376936
16MP0003763_abnormal_thymus_physiology2.22171341
17MP0005174_abnormal_tail_pigmentation2.17881747
18MP0010030_abnormal_orbit_morphology2.15878879
19MP0003329_amyloid_beta_deposits2.07768651
20MP0001545_abnormal_hematopoietic_system2.02291539
21MP0005397_hematopoietic_system_phenotyp2.02291539
22MP0003077_abnormal_cell_cycle2.01854386
23MP0001873_stomach_inflammation2.00687079
24MP0009333_abnormal_splenocyte_physiolog1.95116367
25MP0003300_gastrointestinal_ulcer1.91304603
26MP0004947_skin_inflammation1.84787743
27MP0005666_abnormal_adipose_tissue1.74877724
28MP0000751_myopathy1.72898465
29MP0001348_abnormal_lacrimal_gland1.70647450
30MP0003453_abnormal_keratinocyte_physiol1.68730276
31MP0004858_abnormal_nervous_system1.64594062
32MP0002398_abnormal_bone_marrow1.63945531
33MP0003191_abnormal_cellular_cholesterol1.61480159
34MP0005075_abnormal_melanosome_morpholog1.59601170
35MP0000371_diluted_coat_color1.58385524
36MP0003866_abnormal_defecation1.55331339
37MP0003786_premature_aging1.55213798
38MP0002396_abnormal_hematopoietic_system1.54852520
39MP0010094_abnormal_chromosome_stability1.51628495
40MP0000703_abnormal_thymus_morphology1.51244956
41MP0000858_altered_metastatic_potential1.50596700
42MP0002254_reproductive_system_inflammat1.49918389
43MP0001730_embryonic_growth_arrest1.44554005
44MP0000689_abnormal_spleen_morphology1.44206379
45MP0000490_abnormal_crypts_of1.42669069
46MP0002419_abnormal_innate_immunity1.42282817
47MP0002796_impaired_skin_barrier1.41577480
48MP0005375_adipose_tissue_phenotype1.40166343
49MP0002751_abnormal_autonomic_nervous1.39310189
50MP0002722_abnormal_immune_system1.39089093
51MP0009379_abnormal_foot_pigmentation1.38620463
52MP0005409_darkened_coat_color1.38101947
53MP0001905_abnormal_dopamine_level1.35988036
54MP0001800_abnormal_humoral_immune1.31173572
55MP0005499_abnormal_olfactory_system1.27854898
56MP0005394_taste/olfaction_phenotype1.27854898
57MP0005501_abnormal_skin_physiology1.26681971
58MP0010155_abnormal_intestine_physiology1.25362936
59MP0003091_abnormal_cell_migration1.24486119
60MP0008770_decreased_survivor_rate1.22975918
61MP0000716_abnormal_immune_system1.20526023
62MP0002877_abnormal_melanocyte_morpholog1.20082360
63MP0000358_abnormal_cell_content/1.19515830
64MP0000313_abnormal_cell_death1.19085733
65MP0004381_abnormal_hair_follicle1.18820744
66MP0008789_abnormal_olfactory_epithelium1.18778024
67MP0008932_abnormal_embryonic_tissue1.17941383
68MP0008058_abnormal_DNA_repair1.17764756
69MP0002998_abnormal_bone_remodeling1.16016315
70MP0004808_abnormal_hematopoietic_stem1.15518212
71MP0000759_abnormal_skeletal_muscle1.15339879
72MP0002429_abnormal_blood_cell1.14814174
73MP0000350_abnormal_cell_proliferation1.13714283
74MP0003279_aneurysm1.12736775
75MP0001835_abnormal_antigen_presentation1.12638824
76MP0006082_CNS_inflammation1.12446638
77MP0003566_abnormal_cell_adhesion1.12103497
78MP0000678_abnormal_parathyroid_gland1.12071184
79MP0002019_abnormal_tumor_incidence1.11761946
80MP0002723_abnormal_immune_serum1.09868934
81MP0006292_abnormal_olfactory_placode1.09617981
82MP0002249_abnormal_larynx_morphology1.09175175
83MP0005670_abnormal_white_adipose1.09164147
84MP0002080_prenatal_lethality1.08759819
85MP0003075_altered_response_to1.08348497
86MP0005645_abnormal_hypothalamus_physiol1.07747037
87MP0000733_abnormal_muscle_development1.07341948
88MP0002420_abnormal_adaptive_immunity1.06887656
89MP0002148_abnormal_hypersensitivity_rea1.06268051
90MP0001819_abnormal_immune_cell1.04921954
91MP0002132_abnormal_respiratory_system1.04108963
92MP0004859_abnormal_synaptic_plasticity1.03715425
93MP0004087_abnormal_muscle_fiber1.02562484
94MP0004130_abnormal_muscle_cell1.01545548
95MP0005025_abnormal_response_to1.01266834
96MP0001533_abnormal_skeleton_physiology1.01054275
97MP0002085_abnormal_embryonic_tissue1.00832795
98MP0000003_abnormal_adipose_tissue1.00279151
99MP0001790_abnormal_immune_system1.00139845
100MP0005387_immune_system_phenotype1.00139845
101MP0003119_abnormal_digestive_system0.99002957
102MP0006035_abnormal_mitochondrial_morpho0.95608047
103MP0004811_abnormal_neuron_physiology0.95538907
104MP0009785_altered_susceptibility_to0.95337343
105MP0005076_abnormal_cell_differentiation0.94991756
106MP0002084_abnormal_developmental_patter0.94683812
107MP0002452_abnormal_antigen_presenting0.93929052
108MP0008995_early_reproductive_senescence0.93870837
109MP0002089_abnormal_postnatal_growth/wei0.93253183
110MP0008874_decreased_physiological_sensi0.93203309
111MP0002405_respiratory_system_inflammati0.92167520
112MP0003436_decreased_susceptibility_to0.92046569
113MP0001849_ear_inflammation0.91777276
114MP0002733_abnormal_thermal_nociception0.91433633
115MP0009931_abnormal_skin_appearance0.91204161
116MP0001697_abnormal_embryo_size0.89477438
117MP0002163_abnormal_gland_morphology0.88207102
118MP0002160_abnormal_reproductive_system0.87320953
119MP0002075_abnormal_coat/hair_pigmentati0.86872861
120MP0003123_paternal_imprinting0.86807870
121MP0005000_abnormal_immune_tolerance0.86311421
122MP0005464_abnormal_platelet_physiology0.85829641
123MP0000747_muscle_weakness0.85802319
124MP0000955_abnormal_spinal_cord0.85749643
125MP0004510_myositis0.85651334
126MP0005330_cardiomyopathy0.85543204
127MP0000750_abnormal_muscle_regeneration0.85228271
128MP0002184_abnormal_innervation0.85218590
129MP0003172_abnormal_lysosome_physiology0.85077454
130MP0004264_abnormal_extraembryonic_tissu0.84242250
131MP0004142_abnormal_muscle_tone0.83936405
132MP0004233_abnormal_muscle_weight0.83922622
133MP0005310_abnormal_salivary_gland0.82126886
134MP0001853_heart_inflammation0.82067858
135MP0001958_emphysema0.81719050
136MP0001851_eye_inflammation0.81672463
137MP0001845_abnormal_inflammatory_respons0.81642983
138MP0001293_anophthalmia0.81373771
139MP0009672_abnormal_birth_weight0.79435509
140MP0010630_abnormal_cardiac_muscle0.79313179
141MP0000604_amyloidosis0.78559154
142MP0000015_abnormal_ear_pigmentation0.78389982
143MP0002638_abnormal_pupillary_reflex0.78335791
144MP0005671_abnormal_response_to0.77926549
145MP0003861_abnormal_nervous_system0.77633894
146MP0008469_abnormal_protein_level0.77297440
147MP0003303_peritoneal_inflammation0.77137283
148MP0002933_joint_inflammation0.76958076
149MP0002086_abnormal_extraembryonic_tissu0.76236511
150MP0003828_pulmonary_edema0.75025546
151MP0001970_abnormal_pain_threshold0.74990763
152MP0004197_abnormal_fetal_growth/weight/0.74125422
153MP0005621_abnormal_cell_physiology0.74095209
154MP0005023_abnormal_wound_healing0.73917309
155MP0003638_abnormal_response/metabolism_0.73696591

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)4.19832867
2Abnormality of cells of the erythroid lineage (HP:0012130)4.08746804
3Reticulocytopenia (HP:0001896)3.62644495
4Distal lower limb muscle weakness (HP:0009053)3.54520444
5Abnormal number of erythroid precursors (HP:0012131)3.44142572
6Albinism (HP:0001022)3.38215904
7Obstructive sleep apnea (HP:0002870)3.31893731
8Cerebral hypomyelination (HP:0006808)3.25482767
9Centrally nucleated skeletal muscle fibers (HP:0003687)3.19195093
10Pallor (HP:0000980)3.15841592
11Poikiloderma (HP:0001029)3.09707492
12Myopathic facies (HP:0002058)3.05117570
13Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.01209432
14Abnormality of the lower motor neuron (HP:0002366)2.98364655
15Eczematoid dermatitis (HP:0000976)2.97218995
16Exercise-induced myalgia (HP:0003738)2.85504042
17Myokymia (HP:0002411)2.84896953
18Distal lower limb amyotrophy (HP:0008944)2.84753077
19Renal salt wasting (HP:0000127)2.84390183
20Increased connective tissue (HP:0009025)2.79035502
21Rough bone trabeculation (HP:0100670)2.78328263
22Visual hallucinations (HP:0002367)2.77763634
23Personality changes (HP:0000751)2.74329231
24Absent thumb (HP:0009777)2.70072946
25Elevated erythrocyte sedimentation rate (HP:0003565)2.69928133
26Selective tooth agenesis (HP:0001592)2.69212747
27Ependymoma (HP:0002888)2.68616358
28Carpal bone hypoplasia (HP:0001498)2.68274263
29Concave nail (HP:0001598)2.66063561
30Abnormality of skeletal muscle fiber size (HP:0012084)2.56569661
31Achilles tendon contracture (HP:0001771)2.55646715
32Abnormality of T cell physiology (HP:0011840)2.55567539
33Basal cell carcinoma (HP:0002671)2.55399347
34Hyponatremia (HP:0002902)2.53841098
35Oral leukoplakia (HP:0002745)2.52872184
36Broad face (HP:0000283)2.52421406
37Increased variability in muscle fiber diameter (HP:0003557)2.51381507
38Increased IgE level (HP:0003212)2.49332047
39Thin bony cortex (HP:0002753)2.44788423
40Cerebral aneurysm (HP:0004944)2.44637471
41Chronic otitis media (HP:0000389)2.44068672
42Colitis (HP:0002583)2.44030545
43Pustule (HP:0200039)2.43051757
44Polygenic inheritance (HP:0010982)2.39194405
45Ragged-red muscle fibers (HP:0003200)2.39058950
46Gastrointestinal stroma tumor (HP:0100723)2.37838376
47Ulnar bowing (HP:0003031)2.37194363
48Macrocytic anemia (HP:0001972)2.32321901
49Multiple enchondromatosis (HP:0005701)2.31078365
50Trismus (HP:0000211)2.29501306
51Abnormality of the Achilles tendon (HP:0005109)2.26014357
52Stomatitis (HP:0010280)2.25808567
53Stridor (HP:0010307)2.23911572
54Intestinal fistula (HP:0100819)2.23891197
55Orthostatic hypotension (HP:0001278)2.23780379
56Annular pancreas (HP:0001734)2.23453847
57Bulbar palsy (HP:0001283)2.22461360
58Easy fatigability (HP:0003388)2.20588230
59Type 1 muscle fiber predominance (HP:0003803)2.19955286
60Vertebral compression fractures (HP:0002953)2.18714856
61Difficulty climbing stairs (HP:0003551)2.17765187
62Recurrent abscess formation (HP:0002722)2.17012742
63Increased cerebral lipofuscin (HP:0011813)2.16929456
64Premature graying of hair (HP:0002216)2.16427092
65Poor suck (HP:0002033)2.15321518
66Rectal fistula (HP:0100590)2.15167699
67Rectovaginal fistula (HP:0000143)2.15167699
68Asymmetric septal hypertrophy (HP:0001670)2.14403570
69Amyotrophic lateral sclerosis (HP:0007354)2.14017630
70Hemorrhage of the eye (HP:0011885)2.13668346
71Failure to thrive in infancy (HP:0001531)2.13593193
72Abnormality of the labia minora (HP:0012880)2.13123512
73Nasal polyposis (HP:0100582)2.13048725
74Abnormality of T cells (HP:0002843)2.10916865
75Abnormality of sodium homeostasis (HP:0010931)2.10863200
76Panhypogammaglobulinemia (HP:0003139)2.10290438
77Dysostosis multiplex (HP:0000943)2.10034422
78Urethral obstruction (HP:0000796)2.09835674
79Abnormality of the motor neurons (HP:0002450)2.09184348
80Abnormal neuron morphology (HP:0012757)2.09184348
81Vaginal fistula (HP:0004320)2.08327225
82Obstructive lung disease (HP:0006536)2.07779784
83Chronic obstructive pulmonary disease (HP:0006510)2.07779784
84Atrophy/Degeneration involving motor neurons (HP:0007373)2.07659324
85Progressive neurologic deterioration (HP:0002344)2.06541011
86Asplenia (HP:0001746)2.06153525
87Overlapping toe (HP:0001845)2.06048161
88Tongue fasciculations (HP:0001308)2.05571862
89Abnormality of macrophages (HP:0004311)2.03202253
90Hypokalemic alkalosis (HP:0001949)2.02211801
91IgG deficiency (HP:0004315)2.01541452
92Progressive muscle weakness (HP:0003323)2.00800625
93Hydroureter (HP:0000072)1.98928723
94Aplasia/hypoplasia of the humerus (HP:0006507)1.98680820
95Protrusio acetabuli (HP:0003179)1.98546934
96Lower limb amyotrophy (HP:0007210)1.98203917
97Facial hemangioma (HP:0000329)1.97433011
98Hypertensive crisis (HP:0100735)1.96230260
99Hypergammaglobulinemia (HP:0010702)1.95957314
100Hypertriglyceridemia (HP:0002155)1.95822477
101Cellular immunodeficiency (HP:0005374)1.94392866
102Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.94062542
103Decreased activity of mitochondrial respiratory chain (HP:0008972)1.94062542
104Upper limb amyotrophy (HP:0009129)1.93289448
105Distal upper limb amyotrophy (HP:0007149)1.93289448
106Aplastic anemia (HP:0001915)1.93108613
107Increased neuronal autofluorescent lipopigment (HP:0002074)1.93006785
108Emphysema (HP:0002097)1.92740440
109Increased serum ferritin (HP:0003281)1.91849026
110Rib fusion (HP:0000902)1.90731859
111Recurrent bronchitis (HP:0002837)1.90704871
112Recurrent viral infections (HP:0004429)1.90033911
113Mildly elevated creatine phosphokinase (HP:0008180)1.89614847
114Hyperactive renin-angiotensin system (HP:0000841)1.89509665
115Recurrent bacterial skin infections (HP:0005406)1.89408471
116Iris hypopigmentation (HP:0007730)1.89100727
117Muscle fibrillation (HP:0010546)1.89099734
118Disproportionate tall stature (HP:0001519)1.88475556
119Mediastinal lymphadenopathy (HP:0100721)1.88272115
120Cellulitis (HP:0100658)1.88007593
121Absent radius (HP:0003974)1.87645571
122Neuronal loss in central nervous system (HP:0002529)1.85180630
123Colon cancer (HP:0003003)1.85140220
124Muscle stiffness (HP:0003552)1.85039914
125Abnormality of the fingertips (HP:0001211)1.84704682
126Abnormality of the thoracic spine (HP:0100711)1.84507426
127Muscle fiber inclusion bodies (HP:0100299)1.84375989
128Ankle clonus (HP:0011448)1.82627732
129Spinal muscular atrophy (HP:0007269)1.81795891
130Turricephaly (HP:0000262)1.81618990
131Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.81400119
132Generalized amyotrophy (HP:0003700)1.81167080
133Segmental peripheral demyelination/remyelination (HP:0003481)1.81159057
134Inflammation of the large intestine (HP:0002037)1.79980610
135Lymphoma (HP:0002665)1.79489739
136Abnormal delayed hypersensitivity skin test (HP:0002963)1.79191439
137Slow saccadic eye movements (HP:0000514)1.77902642
138Premature skin wrinkling (HP:0100678)1.77732930
139Axonal loss (HP:0003447)1.77543127
140Hyperacusis (HP:0010780)1.77350782
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.77225455
142Rhabdomyolysis (HP:0003201)1.77054766
143Gastrointestinal inflammation (HP:0004386)1.76960884
144Meningitis (HP:0001287)1.76871995
145Thoracic kyphosis (HP:0002942)1.76160573
146Nemaline bodies (HP:0003798)1.75641045
147Microretrognathia (HP:0000308)1.75531505
148Round ear (HP:0100830)1.75364899
149Chronic sinusitis (HP:0011109)1.74624946
150Death in infancy (HP:0001522)1.74607822
151Aplasia/Hypoplasia of the patella (HP:0006498)1.74004835
152Biconcave vertebral bodies (HP:0004586)1.72057980
153Vertebral fusion (HP:0002948)1.71906843
154Mitral regurgitation (HP:0001653)1.71814078
155Abnormal number of incisors (HP:0011064)1.71773946
156Absent forearm bone (HP:0003953)1.71485711
157Aplasia involving forearm bones (HP:0009822)1.71485711
158Unsteady gait (HP:0002317)1.71153880
159Hypercortisolism (HP:0001578)1.70463903
160Broad distal phalanx of finger (HP:0009836)1.70421533
161J-shaped sella turcica (HP:0002680)1.69681623
162Rectal prolapse (HP:0002035)1.69468379
163Patellar aplasia (HP:0006443)1.68798587
164Gingivitis (HP:0000230)1.68574693
165Dysautonomia (HP:0002459)1.68571196
166IgM deficiency (HP:0002850)1.68151209
167Reticulocytosis (HP:0001923)1.67907170
168Ulnar deviation of the wrist (HP:0003049)1.67288417
169Joint stiffness (HP:0001387)1.67198285
170Purpura (HP:0000979)1.66851768
171Split foot (HP:0001839)1.65662691
172Emotional lability (HP:0000712)1.65658860
173Long palpebral fissure (HP:0000637)1.65380571
174Horseshoe kidney (HP:0000085)1.65021113
175Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64210380
176Severe visual impairment (HP:0001141)1.64208527
177Abnormality of the nasal mucosa (HP:0000433)1.63903941
178Recurrent fungal infections (HP:0002841)1.63843014
179Foot dorsiflexor weakness (HP:0009027)1.63658638
180Agammaglobulinemia (HP:0004432)1.63382157
181Germ cell neoplasia (HP:0100728)1.62302953
182Growth hormone excess (HP:0000845)1.61578973
183Muscle fiber splitting (HP:0003555)1.60779332
184Supernumerary nipples (HP:0002558)1.60426209
185Cerebral inclusion bodies (HP:0100314)1.60233581
186Seborrheic dermatitis (HP:0001051)1.59715717
187Abnormality of polysaccharide metabolism (HP:0011012)1.59624532
188Abnormality of glycosaminoglycan metabolism (HP:0004371)1.59624532
189Abnormality of mucopolysaccharide metabolism (HP:0011020)1.59624532
190Thin ribs (HP:0000883)1.59505585
191Prolonged bleeding time (HP:0003010)1.59458761
192Upper motor neuron abnormality (HP:0002127)1.59334688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.72423047
2SMG13.64917677
3MAP3K113.54137207
4MAP4K13.05271860
5BUB12.85361135
6SIK12.72152881
7ICK2.48056547
8IRAK32.34115505
9SCYL22.26064162
10ERN12.09234351
11TTN2.06911024
12EEF2K2.06037633
13TRIB31.95907650
14RPS6KB21.88859909
15TAOK11.88325584
16SIK21.82898594
17DYRK31.82175765
18CDK191.77401368
19ZAP701.74334850
20PIM21.68738809
21UHMK11.65334355
22NME21.63499779
23MAP3K91.63322823
24RIPK41.60074862
25GRK61.58450932
26RIPK11.54757301
27TYRO31.54140260
28DYRK21.49173216
29TESK21.44323682
30TNK21.42150692
31FGFR41.38630327
32EPHA21.38184836
33LMTK21.31402124
34PRPF4B1.27925590
35BCKDK1.26114587
36DAPK11.25043311
37ALK1.21275587
38PKN21.16433991
39CDK71.14428227
40IRAK41.10860362
41HIPK21.10822640
42MAPK151.10596209
43PRKD31.07854316
44RPS6KL11.07363669
45RPS6KC11.07363669
46ARAF1.04182389
47MAPK121.02319220
48RPS6KA21.02058028
49IRAK21.01401366
50SIK30.99443183
51TESK10.99267796
52LRRK20.98024400
53PDPK10.95673406
54CSNK1G30.95578098
55NEK20.95332029
56NTRK20.93243827
57MAP3K120.92453826
58CDC42BPA0.92008718
59FES0.91290539
60TSSK60.91008359
61MATK0.90458521
62TLK10.88903074
63MAP2K30.87742302
64PRKCI0.86082037
65PHKG20.85954789
66PHKG10.85954789
67MAP3K30.84900725
68PRKD20.84301797
69MAP2K60.84011170
70MAPKAPK30.83593680
71MAP3K140.83202218
72MAP2K20.80784664
73RPS6KA60.79968521
74DAPK30.79563819
75TXK0.79104308
76PIM10.78794880
77MAPK110.78395713
78PTK60.78202393
79AURKA0.76667265
80BLK0.76536339
81WEE10.74531793
82BTK0.74075468
83CAMKK10.71604799
84SYK0.71347822
85VRK20.70984547
86GRK50.70852532
87PDGFRA0.67670474
88PDK10.66876104
89CSK0.65761671
90EPHB10.65733323
91PRKG20.64976003
92PAK40.63195780
93YES10.60641112
94DAPK20.60053895
95MAP3K70.57361066
96LATS20.57217366
97MAPK40.56105936
98KDR0.55710500
99MAP3K80.55600359
100JAK30.54863119
101TYK20.54528466
102CDK40.54147136
103CSNK1A1L0.53500420
104PAK60.53405182
105TBK10.52971392
106KSR20.52523879
107MTOR0.51592046
108DDR20.51563561
109IKBKB0.51555469
110MAP3K130.51552452
111IKBKE0.51442998
112CSF1R0.51298343
113CSNK1G20.50843805
114RPS6KA40.50347911
115MARK20.50263270
116ITK0.49849463
117PAK10.49793178
118TAOK20.48406395
119STK100.48372759
120SRPK10.47701843
121CSNK1G10.47497832
122DYRK1B0.46953020
123CDK120.46604165
124TGFBR10.46506549
125RPS6KA10.46267813
126MAPK70.46009802
127MARK30.43423332
128MAP3K10.43321836
129CDK20.43177176
130IRAK10.43126931
131BMX0.42074152
132ILK0.41401775
133HCK0.38585772
134LCK0.38482495
135BRAF0.38400502
136RPS6KA50.38027133
137MAP3K60.35957451
138ABL20.34181435
139AKT20.33106464
140CDK60.32660117
141MAPKAPK20.32399193

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.26246898
2DNA replication_Homo sapiens_hsa030303.29766479
3Spliceosome_Homo sapiens_hsa030403.16919813
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12771099
5Base excision repair_Homo sapiens_hsa034102.88425121
6Proteasome_Homo sapiens_hsa030502.86018543
7Mismatch repair_Homo sapiens_hsa034302.77672378
8Other glycan degradation_Homo sapiens_hsa005112.69466492
9Sulfur relay system_Homo sapiens_hsa041222.56894142
10Primary immunodeficiency_Homo sapiens_hsa053402.54707706
11RNA transport_Homo sapiens_hsa030132.38690711
12RNA polymerase_Homo sapiens_hsa030202.30283541
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00415444
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.96617038
15Pyrimidine metabolism_Homo sapiens_hsa002401.90060801
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82982384
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77424224
18Folate biosynthesis_Homo sapiens_hsa007901.75259422
19Non-small cell lung cancer_Homo sapiens_hsa052231.71873773
20Osteoclast differentiation_Homo sapiens_hsa043801.71177152
21Nucleotide excision repair_Homo sapiens_hsa034201.66457962
22Leishmaniasis_Homo sapiens_hsa051401.59022418
23mRNA surveillance pathway_Homo sapiens_hsa030151.55707300
24Notch signaling pathway_Homo sapiens_hsa043301.51971170
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47263437
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.42945394
27Acute myeloid leukemia_Homo sapiens_hsa052211.34994137
28Pancreatic cancer_Homo sapiens_hsa052121.33652628
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.30775890
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29305293
31Epstein-Barr virus infection_Homo sapiens_hsa051691.17053088
32B cell receptor signaling pathway_Homo sapiens_hsa046621.16477901
33Endometrial cancer_Homo sapiens_hsa052131.15115742
34GnRH signaling pathway_Homo sapiens_hsa049121.13956852
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10653433
36Toxoplasmosis_Homo sapiens_hsa051451.08780597
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.07307531
38Renal cell carcinoma_Homo sapiens_hsa052111.06101136
39Influenza A_Homo sapiens_hsa051641.05729078
40Hepatitis C_Homo sapiens_hsa051601.04990245
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04775488
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.02778254
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01580206
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01530925
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.99532031
46TNF signaling pathway_Homo sapiens_hsa046680.99463903
47Homologous recombination_Homo sapiens_hsa034400.99073793
48VEGF signaling pathway_Homo sapiens_hsa043700.98409140
49Tuberculosis_Homo sapiens_hsa051520.98012234
50Shigellosis_Homo sapiens_hsa051310.97828375
51ErbB signaling pathway_Homo sapiens_hsa040120.97620678
52T cell receptor signaling pathway_Homo sapiens_hsa046600.95592373
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95450962
54Glioma_Homo sapiens_hsa052140.93789999
55p53 signaling pathway_Homo sapiens_hsa041150.93422469
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.91390973
57Galactose metabolism_Homo sapiens_hsa000520.91264010
58Insulin resistance_Homo sapiens_hsa049310.90654366
59Synaptic vesicle cycle_Homo sapiens_hsa047210.90341617
60mTOR signaling pathway_Homo sapiens_hsa041500.89855419
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88326551
62Cell cycle_Homo sapiens_hsa041100.87695424
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87266709
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87165977
65Apoptosis_Homo sapiens_hsa042100.86474323
66Thyroid cancer_Homo sapiens_hsa052160.85817126
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85275177
68Herpes simplex infection_Homo sapiens_hsa051680.84739615
69RNA degradation_Homo sapiens_hsa030180.83874085
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83113307
71Chronic myeloid leukemia_Homo sapiens_hsa052200.82644631
72Parkinsons disease_Homo sapiens_hsa050120.82450404
73Regulation of autophagy_Homo sapiens_hsa041400.82308795
74Biosynthesis of amino acids_Homo sapiens_hsa012300.81564285
75Lysosome_Homo sapiens_hsa041420.80857404
76Antigen processing and presentation_Homo sapiens_hsa046120.80853120
77AMPK signaling pathway_Homo sapiens_hsa041520.80800701
78Prolactin signaling pathway_Homo sapiens_hsa049170.80422652
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80233398
80Long-term potentiation_Homo sapiens_hsa047200.79075637
81HTLV-I infection_Homo sapiens_hsa051660.78728145
82Inositol phosphate metabolism_Homo sapiens_hsa005620.78368041
83Choline metabolism in cancer_Homo sapiens_hsa052310.76160044
84Prion diseases_Homo sapiens_hsa050200.75797827
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75389967
86Colorectal cancer_Homo sapiens_hsa052100.75077839
87One carbon pool by folate_Homo sapiens_hsa006700.74411343
88Viral carcinogenesis_Homo sapiens_hsa052030.74072636
89Estrogen signaling pathway_Homo sapiens_hsa049150.74004052
90Autoimmune thyroid disease_Homo sapiens_hsa053200.73272293
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72448586
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72108118
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68808906
94Bladder cancer_Homo sapiens_hsa052190.68739376
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67788390
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.67376521
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66167312
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.65762366
99Platelet activation_Homo sapiens_hsa046110.65639755
100Carbon metabolism_Homo sapiens_hsa012000.65485243
101Amoebiasis_Homo sapiens_hsa051460.64847677
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63908110
103Chemokine signaling pathway_Homo sapiens_hsa040620.63697214
104HIF-1 signaling pathway_Homo sapiens_hsa040660.63272158
105Viral myocarditis_Homo sapiens_hsa054160.61854322
106Pentose phosphate pathway_Homo sapiens_hsa000300.59794914
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58690205
108Huntingtons disease_Homo sapiens_hsa050160.58487461
109Malaria_Homo sapiens_hsa051440.57859909
110Oxidative phosphorylation_Homo sapiens_hsa001900.57708366
111Fructose and mannose metabolism_Homo sapiens_hsa000510.55231986
112Staphylococcus aureus infection_Homo sapiens_hsa051500.55073644
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54615581
114Purine metabolism_Homo sapiens_hsa002300.54003370
115Oocyte meiosis_Homo sapiens_hsa041140.53187751
116Measles_Homo sapiens_hsa051620.52364435
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51875196
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.50621910
119Prostate cancer_Homo sapiens_hsa052150.50166393
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48904299
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48782561
122Arginine biosynthesis_Homo sapiens_hsa002200.48714610
123Graft-versus-host disease_Homo sapiens_hsa053320.47777012
124Allograft rejection_Homo sapiens_hsa053300.47609632
125Basal transcription factors_Homo sapiens_hsa030220.47385962
126Asthma_Homo sapiens_hsa053100.45506982
127Basal cell carcinoma_Homo sapiens_hsa052170.45021115
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43749282
129Arginine and proline metabolism_Homo sapiens_hsa003300.41787856
130Fanconi anemia pathway_Homo sapiens_hsa034600.40205853
131Hippo signaling pathway_Homo sapiens_hsa043900.40023099
132Endocytosis_Homo sapiens_hsa041440.38340034
133Hematopoietic cell lineage_Homo sapiens_hsa046400.38311835
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38215204
135Hedgehog signaling pathway_Homo sapiens_hsa043400.37541251
136Hepatitis B_Homo sapiens_hsa051610.37203150
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35987581
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.33422264
139Pathways in cancer_Homo sapiens_hsa052000.32822930
140Insulin signaling pathway_Homo sapiens_hsa049100.32185220
141MAPK signaling pathway_Homo sapiens_hsa040100.31846900
142Salmonella infection_Homo sapiens_hsa051320.31736140
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.31589064
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30225130
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30089773
146Gap junction_Homo sapiens_hsa045400.28676832
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.28415594
148Collecting duct acid secretion_Homo sapiens_hsa049660.28099913
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.27936374
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27872036

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