GTPBP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.03746145
2nuclear pore complex assembly (GO:0051292)4.97375554
3establishment of integrated proviral latency (GO:0075713)4.50294142
4mitotic metaphase plate congression (GO:0007080)4.49266441
5DNA replication initiation (GO:0006270)4.31407409
6maturation of SSU-rRNA (GO:0030490)4.20964806
7nucleobase biosynthetic process (GO:0046112)4.17654382
8formation of translation preinitiation complex (GO:0001731)4.13479778
9ribosome assembly (GO:0042255)4.05211712
10DNA unwinding involved in DNA replication (GO:0006268)4.01865408
11DNA strand elongation involved in DNA replication (GO:0006271)4.01366587
12purine nucleobase biosynthetic process (GO:0009113)4.00309768
13metaphase plate congression (GO:0051310)3.99437795
14IMP biosynthetic process (GO:0006188)3.96141144
15DNA replication checkpoint (GO:0000076)3.96055982
16protein localization to kinetochore (GO:0034501)3.96013483
17pore complex assembly (GO:0046931)3.93939530
18mitotic nuclear envelope disassembly (GO:0007077)3.91875894
19chromatin remodeling at centromere (GO:0031055)3.89882189
20* ribosome biogenesis (GO:0042254)3.85979712
21CENP-A containing nucleosome assembly (GO:0034080)3.85135413
22DNA strand elongation (GO:0022616)3.82904344
23telomere maintenance via semi-conservative replication (GO:0032201)3.78884368
24DNA replication-dependent nucleosome assembly (GO:0006335)3.77058771
25DNA replication-dependent nucleosome organization (GO:0034723)3.77058771
26kinetochore organization (GO:0051383)3.75293211
27IMP metabolic process (GO:0046040)3.66749171
28DNA replication-independent nucleosome organization (GO:0034724)3.64529788
29DNA replication-independent nucleosome assembly (GO:0006336)3.64529788
30establishment of chromosome localization (GO:0051303)3.61825420
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.61781062
32membrane disassembly (GO:0030397)3.60866282
33nuclear envelope disassembly (GO:0051081)3.60866282
34* ribonucleoprotein complex biogenesis (GO:0022613)3.56152510
35tRNA aminoacylation for protein translation (GO:0006418)3.55100110
36telomere maintenance via recombination (GO:0000722)3.54411825
37amino acid activation (GO:0043038)3.53141577
38tRNA aminoacylation (GO:0043039)3.53141577
39ribosomal large subunit biogenesis (GO:0042273)3.51971490
40meiotic chromosome segregation (GO:0045132)3.49877336
41ribosomal small subunit assembly (GO:0000028)3.48892431
42attachment of spindle microtubules to kinetochore (GO:0008608)3.47547841
43establishment of viral latency (GO:0019043)3.46104126
44regulation of spindle organization (GO:0090224)3.42489705
45mitotic recombination (GO:0006312)3.41662420
46folic acid-containing compound biosynthetic process (GO:0009396)3.41644052
47mitochondrial RNA metabolic process (GO:0000959)3.38641694
48non-recombinational repair (GO:0000726)3.37460993
49double-strand break repair via nonhomologous end joining (GO:0006303)3.37460993
50negative regulation of ligase activity (GO:0051352)3.36800857
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36800857
52rRNA processing (GO:0006364)3.36632376
53histone exchange (GO:0043486)3.35555800
54viral mRNA export from host cell nucleus (GO:0046784)3.33772201
55protein localization to chromosome, centromeric region (GO:0071459)3.33580430
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33247837
57telomere maintenance via telomere lengthening (GO:0010833)3.31917897
58kinetochore assembly (GO:0051382)3.31843798
59regulation of translational fidelity (GO:0006450)3.29712267
60spliceosomal snRNP assembly (GO:0000387)3.26794212
61rRNA metabolic process (GO:0016072)3.26635762
62protein complex localization (GO:0031503)3.26605544
63mitotic chromosome condensation (GO:0007076)3.25382490
64cellular protein complex localization (GO:0034629)3.23714159
65regulation of helicase activity (GO:0051095)3.23428805
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19711625
67maturation of 5.8S rRNA (GO:0000460)3.19217782
68regulation of nuclear cell cycle DNA replication (GO:0033262)3.18509582
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16749058
70spindle checkpoint (GO:0031577)3.15819353
71protein K6-linked ubiquitination (GO:0085020)3.13361212
72tRNA methylation (GO:0030488)3.13056898
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.09732081
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09732081
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09732081
76negative regulation of sister chromatid segregation (GO:0033046)3.09732081
77negative regulation of mRNA processing (GO:0050686)3.09549999
78negative regulation of chromosome segregation (GO:0051985)3.09255228
79cell cycle G1/S phase transition (GO:0044843)3.07211081
80G1/S transition of mitotic cell cycle (GO:0000082)3.07211081
81mitotic sister chromatid cohesion (GO:0007064)3.07076957
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.06876480
83DNA ligation (GO:0006266)3.06534777
84regulation of centrosome cycle (GO:0046605)3.05953380
85regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04865113
86mitotic spindle checkpoint (GO:0071174)3.04190779
87spindle assembly checkpoint (GO:0071173)3.02945368
88pteridine-containing compound biosynthetic process (GO:0042559)3.02569371
89mitotic sister chromatid segregation (GO:0000070)3.02422297
90rRNA methylation (GO:0031167)3.02143303
91pseudouridine synthesis (GO:0001522)3.01387885
92mitotic spindle assembly checkpoint (GO:0007094)3.01134639
93DNA duplex unwinding (GO:0032508)3.01067672
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00893413
95DNA geometric change (GO:0032392)3.00639875
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99994361
97regulation of double-strand break repair via homologous recombination (GO:0010569)2.99218716
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97451125
99proteasome assembly (GO:0043248)2.97171428
100regulation of mitotic spindle organization (GO:0060236)2.96332523
101ribosomal small subunit biogenesis (GO:0042274)2.95707922
102regulation of posttranscriptional gene silencing (GO:0060147)2.95515069
103regulation of gene silencing by miRNA (GO:0060964)2.95515069
104regulation of gene silencing by RNA (GO:0060966)2.95515069
105regulation of centriole replication (GO:0046599)2.95299444
106positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94569777
107regulation of chromosome segregation (GO:0051983)2.94524662
108regulation of translational termination (GO:0006449)2.93668829
109somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.93247128
110isotype switching (GO:0045190)2.93247128
111somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.93247128
112positive regulation of chromosome segregation (GO:0051984)2.91992315
113transcription elongation from RNA polymerase I promoter (GO:0006362)2.91588625
114transcription-coupled nucleotide-excision repair (GO:0006283)2.89909037
115chromatin assembly or disassembly (GO:0006333)2.88817608
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88125729
117somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88039517
118somatic hypermutation of immunoglobulin genes (GO:0016446)2.88039517
119rRNA modification (GO:0000154)2.87398657
120regulation of mitotic sister chromatid separation (GO:0010965)2.87035404
121regulation of mitotic sister chromatid segregation (GO:0033047)2.87035404
122regulation of sister chromatid segregation (GO:0033045)2.87035404
123termination of RNA polymerase I transcription (GO:0006363)2.86296863
124translational initiation (GO:0006413)2.84124611
125regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82582399
126RNA splicing, via transesterification reactions (GO:0000375)2.81620213
127transcription elongation from RNA polymerase III promoter (GO:0006385)2.81061890
128termination of RNA polymerase III transcription (GO:0006386)2.81061890
129sister chromatid segregation (GO:0000819)2.80917635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.02125755
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.50989055
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.96654869
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.80477751
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17014887
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14955116
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13765237
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12810047
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.02209709
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94321780
11* GABP_17652178_ChIP-ChIP_JURKAT_Human2.90528950
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68494592
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67757498
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.67321526
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61250280
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.53534536
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39276101
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38437769
19VDR_23849224_ChIP-Seq_CD4+_Human2.37120159
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.30714930
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25917656
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24617992
23AR_21909140_ChIP-Seq_LNCAP_Human2.23802038
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22731603
25XRN2_22483619_ChIP-Seq_HELA_Human2.22632234
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12675157
27E2F1_21310950_ChIP-Seq_MCF-7_Human2.12550515
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02252968
29ELK1_19687146_ChIP-ChIP_HELA_Human2.02158229
30FOXP3_21729870_ChIP-Seq_TREG_Human1.95858890
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95461863
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92650372
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89829472
34DCP1A_22483619_ChIP-Seq_HELA_Human1.87476264
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82847535
36TTF2_22483619_ChIP-Seq_HELA_Human1.82826914
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78678368
38* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74987638
39* GABP_19822575_ChIP-Seq_HepG2_Human1.71163020
40* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70360857
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65869719
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63076897
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57310410
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55055341
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54798428
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54756318
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.54571999
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51373874
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51182941
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.47818068
51KDM5A_27292631_Chip-Seq_BREAST_Human1.46792774
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43178419
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.42792788
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39121991
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39068044
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38258910
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36896048
58CIITA_25753668_ChIP-Seq_RAJI_Human1.35442881
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34615393
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33848607
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.32037692
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28947503
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.26372703
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24674506
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22181337
66MYC_22102868_ChIP-Seq_BL_Human1.22054481
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20059870
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19958255
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18266153
70TFEB_21752829_ChIP-Seq_HELA_Human1.17248515
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13951126
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11772138
73MYC_18940864_ChIP-ChIP_HL60_Human1.10417562
74* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09577484
75* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09447295
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08863090
77* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06905169
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03745570
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02455215
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02380038
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.02152492
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01188330
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99910123
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99010826
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99010826
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99010826
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98500156
88* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98354263
89* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96437734
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96275759
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.94000732
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92368576
93* CHD1_26751641_Chip-Seq_LNCaP_Human0.91949057
94ZNF263_19887448_ChIP-Seq_K562_Human0.91481985
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91468627
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90050813
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89457218
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.88939833
99* SPI1_23547873_ChIP-Seq_NB4_Human0.88896791
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85842456
101* ELF5_23300383_ChIP-Seq_T47D_Human0.84888243
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84810087
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83818111
104* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82490686
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81548771
106* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80671810
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79839680
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79314085
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78985587
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78285138
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.77993603
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77669196
113* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76137560
114EWS_26573619_Chip-Seq_HEK293_Human0.73407494
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.72061637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.03648511
2MP0010094_abnormal_chromosome_stability4.48345080
3MP0008057_abnormal_DNA_replication4.37653275
4MP0004957_abnormal_blastocyst_morpholog4.23487853
5MP0003111_abnormal_nucleus_morphology4.12647504
6MP0003077_abnormal_cell_cycle3.89191581
7MP0008058_abnormal_DNA_repair3.68487100
8MP0008007_abnormal_cellular_replicative2.92507182
9MP0008877_abnormal_DNA_methylation2.86984029
10MP0008932_abnormal_embryonic_tissue2.63160336
11MP0003123_paternal_imprinting2.56782079
12MP0010352_gastrointestinal_tract_polyps2.37880757
13MP0002396_abnormal_hematopoietic_system2.30379300
14MP0001730_embryonic_growth_arrest2.27330779
15MP0000350_abnormal_cell_proliferation2.22476359
16MP0010307_abnormal_tumor_latency2.18171795
17MP0003786_premature_aging2.16453620
18MP0001672_abnormal_embryogenesis/_devel1.75062524
19MP0005380_embryogenesis_phenotype1.75062524
20MP0001697_abnormal_embryo_size1.66956865
21MP0003718_maternal_effect1.64688195
22MP0003950_abnormal_plasma_membrane1.61482086
23MP0003984_embryonic_growth_retardation1.58484490
24MP0003567_abnormal_fetal_cardiomyocyte1.55579529
25MP0002088_abnormal_embryonic_growth/wei1.54369438
26MP0006035_abnormal_mitochondrial_morpho1.52946495
27MP0000490_abnormal_crypts_of1.52511154
28MP0002877_abnormal_melanocyte_morpholog1.50319652
29MP0004197_abnormal_fetal_growth/weight/1.48376247
30MP0003121_genomic_imprinting1.46790927
31MP0002084_abnormal_developmental_patter1.46196080
32MP0003890_abnormal_embryonic-extraembry1.45140723
33MP0002080_prenatal_lethality1.44565973
34MP0004808_abnormal_hematopoietic_stem1.44512117
35MP0002210_abnormal_sex_determination1.44214452
36MP0001661_extended_life_span1.43717515
37MP0002085_abnormal_embryonic_tissue1.42319640
38MP0002086_abnormal_extraembryonic_tissu1.38260761
39MP0000313_abnormal_cell_death1.35753481
40MP0006036_abnormal_mitochondrial_physio1.34525181
41MP0002019_abnormal_tumor_incidence1.32189971
42MP0004233_abnormal_muscle_weight1.29706839
43MP0001293_anophthalmia1.28322038
44MP0005076_abnormal_cell_differentiation1.23487923
45MP0001145_abnormal_male_reproductive1.21168083
46MP0005501_abnormal_skin_physiology1.16425323
47MP0006292_abnormal_olfactory_placode1.14035772
48MP0003763_abnormal_thymus_physiology1.13944172
49MP0003806_abnormal_nucleotide_metabolis1.12397830
50MP0010030_abnormal_orbit_morphology1.08771522
51MP0001929_abnormal_gametogenesis1.08024211
52MP0009333_abnormal_splenocyte_physiolog1.07953117
53MP0000653_abnormal_sex_gland1.07482050
54MP0010234_abnormal_vibrissa_follicle1.05015426
55MP0001727_abnormal_embryo_implantation1.02672649
56MP0003941_abnormal_skin_development1.02508836
57MP0001835_abnormal_antigen_presentation1.02388559
58MP0002938_white_spotting1.01647512
59MP0001119_abnormal_female_reproductive1.00505438
60MP0000703_abnormal_thymus_morphology0.99492150
61MP0004133_heterotaxia0.99421088
62MP0002398_abnormal_bone_marrow0.99353085
63MP0002697_abnormal_eye_size0.99342941
64MP0003937_abnormal_limbs/digits/tail_de0.97840660
65MP0003186_abnormal_redox_activity0.95849402
66MP0003315_abnormal_perineum_morphology0.94928719
67MP0001545_abnormal_hematopoietic_system0.92589024
68MP0005397_hematopoietic_system_phenotyp0.92589024
69MP0001881_abnormal_mammary_gland0.92506570
70MP0002796_impaired_skin_barrier0.91700891
71MP0001853_heart_inflammation0.89769545
72MP0002722_abnormal_immune_system0.89580007
73MP0009053_abnormal_anal_canal0.87850003
74MP0000689_abnormal_spleen_morphology0.87653848
75MP0002160_abnormal_reproductive_system0.85634959
76MP0005408_hypopigmentation0.85398074
77MP0009672_abnormal_birth_weight0.82800483
78MP0004185_abnormal_adipocyte_glucose0.81335698
79MP0002111_abnormal_tail_morphology0.80993602
80MP0005389_reproductive_system_phenotype0.79391776
81MP0000858_altered_metastatic_potential0.79111185
82MP0001915_intracranial_hemorrhage0.76894830
83MP0009703_decreased_birth_body0.76671275
84MP0000579_abnormal_nail_morphology0.76117498
85MP0003119_abnormal_digestive_system0.75406346
86MP0002429_abnormal_blood_cell0.75055393
87MP0001529_abnormal_vocalization0.74956604
88MP0006072_abnormal_retinal_apoptosis0.74804677
89MP0001286_abnormal_eye_development0.74543092
90MP0000647_abnormal_sebaceous_gland0.74013334
91MP0005384_cellular_phenotype0.73709085
92MP0005623_abnormal_meninges_morphology0.73651469
93MP0000566_synostosis0.72999547
94MP0002060_abnormal_skin_morphology0.72612507
95MP0003787_abnormal_imprinting0.72375952
96MP0001216_abnormal_epidermal_layer0.72025051
97MP0003566_abnormal_cell_adhesion0.71990738
98MP0003448_altered_tumor_morphology0.71891783
99MP0005621_abnormal_cell_physiology0.70377651
100MP0000358_abnormal_cell_content/0.69328828
101MP0000716_abnormal_immune_system0.68990688
102MP0005023_abnormal_wound_healing0.68804736
103MP0002009_preneoplasia0.68288744
104MP0002006_tumorigenesis0.67887551
105MP0003221_abnormal_cardiomyocyte_apopto0.67656198
106MP0003755_abnormal_palate_morphology0.67242320
107MP0004147_increased_porphyrin_level0.65801436
108MP0005671_abnormal_response_to0.65492739
109MP0001800_abnormal_humoral_immune0.65469417
110MP0002163_abnormal_gland_morphology0.65057620
111MP0002234_abnormal_pharynx_morphology0.64767599
112MP0003936_abnormal_reproductive_system0.63659295
113MP0000432_abnormal_head_morphology0.63337738
114MP0000627_abnormal_mammary_gland0.63038267
115MP0002405_respiratory_system_inflammati0.62107069
116MP0000537_abnormal_urethra_morphology0.61404117
117MP0005395_other_phenotype0.59852512
118MP0002452_abnormal_antigen_presenting0.59844623
119MP0002092_abnormal_eye_morphology0.59714037
120MP0009697_abnormal_copulation0.58215527
121MP0002254_reproductive_system_inflammat0.58206615
122MP0003436_decreased_susceptibility_to0.57910116
123MP0000428_abnormal_craniofacial_morphol0.57691655
124MP0003699_abnormal_female_reproductive0.57657675
125MP0000762_abnormal_tongue_morphology0.57502359
126MP0001919_abnormal_reproductive_system0.57331913
127MP0003385_abnormal_body_wall0.57324286
128MP0002277_abnormal_respiratory_mucosa0.57166547
129MP0008995_early_reproductive_senescence0.56253283
130MP0002420_abnormal_adaptive_immunity0.56055043
131MP0001819_abnormal_immune_cell0.55533957
132MP0004272_abnormal_basement_membrane0.55486371
133MP0002233_abnormal_nose_morphology0.53220036
134MP0001243_abnormal_dermal_layer0.53210653

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.02216894
2Chromsome breakage (HP:0040012)4.27599491
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.96634745
4Colon cancer (HP:0003003)3.89099765
5Breast hypoplasia (HP:0003187)3.66705662
6Medulloblastoma (HP:0002885)3.51926410
7Reticulocytopenia (HP:0001896)3.46199565
8Abnormality of glycolysis (HP:0004366)3.37752434
9Carpal bone hypoplasia (HP:0001498)3.25171578
10Abnormality of chromosome stability (HP:0003220)3.23164817
11Agnosia (HP:0010524)3.18557386
12Oral leukoplakia (HP:0002745)3.18474857
13Increased serum pyruvate (HP:0003542)3.17985470
14Abnormality of the labia minora (HP:0012880)3.07249847
15Patellar aplasia (HP:0006443)3.03613892
16Microvesicular hepatic steatosis (HP:0001414)2.98616113
17Meckel diverticulum (HP:0002245)2.98512078
18Abnormality of the preputium (HP:0100587)2.97039497
19Abnormality of cells of the erythroid lineage (HP:0012130)2.92910246
20Degeneration of anterior horn cells (HP:0002398)2.89637623
21Abnormality of the anterior horn cell (HP:0006802)2.89637623
22Abnormal number of erythroid precursors (HP:0012131)2.81159461
23Abnormality of the ileum (HP:0001549)2.79829513
24Aplasia/Hypoplasia of the patella (HP:0006498)2.79261984
25Short middle phalanx of the 5th finger (HP:0004220)2.78856793
26Selective tooth agenesis (HP:0001592)2.77450139
27Absent radius (HP:0003974)2.76325142
28Absent thumb (HP:0009777)2.75709854
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73511020
30Abnormality of alanine metabolism (HP:0010916)2.73511020
31Hyperalaninemia (HP:0003348)2.73511020
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.73061337
33Aplastic anemia (HP:0001915)2.72294246
34Supernumerary spleens (HP:0009799)2.72012310
35Impulsivity (HP:0100710)2.69447806
36Myelodysplasia (HP:0002863)2.67749602
37Ectopic kidney (HP:0000086)2.66133457
38Rough bone trabeculation (HP:0100670)2.64994451
39Ependymoma (HP:0002888)2.64348207
40Progressive muscle weakness (HP:0003323)2.60983200
41Acute necrotizing encephalopathy (HP:0006965)2.57895278
42Abnormality of methionine metabolism (HP:0010901)2.57760078
43Rhabdomyosarcoma (HP:0002859)2.55872991
44Aplasia involving forearm bones (HP:0009822)2.53232117
45Absent forearm bone (HP:0003953)2.53232117
46Type I transferrin isoform profile (HP:0003642)2.52801384
47Acute encephalopathy (HP:0006846)2.52022943
48Volvulus (HP:0002580)2.51822162
49Abnormal mitochondria in muscle tissue (HP:0008316)2.46677094
50Increased CSF lactate (HP:0002490)2.43353028
51Increased serum lactate (HP:0002151)2.40209045
5211 pairs of ribs (HP:0000878)2.39994288
53Overlapping toe (HP:0001845)2.38549360
54Small intestinal stenosis (HP:0012848)2.35787191
55Duodenal stenosis (HP:0100867)2.35787191
56Neoplasm of the pancreas (HP:0002894)2.34371749
57Premature graying of hair (HP:0002216)2.31201964
58Sloping forehead (HP:0000340)2.29805040
59Horseshoe kidney (HP:0000085)2.28363326
60Increased hepatocellular lipid droplets (HP:0006565)2.27743404
61Deviation of the thumb (HP:0009603)2.24069987
62Amaurosis fugax (HP:0100576)2.23477774
63Bone marrow hypocellularity (HP:0005528)2.23330888
64Proximal placement of thumb (HP:0009623)2.23330337
65Abnormal spermatogenesis (HP:0008669)2.22014855
66Cerebral hypomyelination (HP:0006808)2.21170837
67Irregular epiphyses (HP:0010582)2.20552419
68Abnormal number of incisors (HP:0011064)2.16379259
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15587213
70Abnormal protein N-linked glycosylation (HP:0012347)2.15587213
71Abnormal protein glycosylation (HP:0012346)2.15587213
72Abnormal glycosylation (HP:0012345)2.15587213
73Abnormal lung lobation (HP:0002101)2.15544891
74Cerebral edema (HP:0002181)2.15212398
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.14907955
76Short thumb (HP:0009778)2.13301698
77Progressive external ophthalmoplegia (HP:0000590)2.12951623
78Nephroblastoma (Wilms tumor) (HP:0002667)2.09271082
79Cellular immunodeficiency (HP:0005374)2.08786369
80Neoplasm of the oral cavity (HP:0100649)2.08601599
81Facial hemangioma (HP:0000329)2.08571699
82Aplasia/Hypoplasia of the sternum (HP:0006714)2.07383023
83Pancytopenia (HP:0001876)2.06871230
84Tracheoesophageal fistula (HP:0002575)2.06016432
85Reduced antithrombin III activity (HP:0001976)2.05407934
86Macrocytic anemia (HP:0001972)2.03490531
87Glossoptosis (HP:0000162)2.02848065
88Biliary tract neoplasm (HP:0100574)2.02042660
89Triphalangeal thumb (HP:0001199)2.00787621
90Abnormal trabecular bone morphology (HP:0100671)2.00096739
91Cleft eyelid (HP:0000625)2.00051566
92Trismus (HP:0000211)1.99095851
93Pallor (HP:0000980)1.98964565
94Glioma (HP:0009733)1.98768537
95Abnormality of the duodenum (HP:0002246)1.98661832
96Abnormality of serum amino acid levels (HP:0003112)1.97244112
97Mitochondrial inheritance (HP:0001427)1.96208209
98Progressive macrocephaly (HP:0004481)1.94723065
99Lipid accumulation in hepatocytes (HP:0006561)1.94333169
100Abnormality of the pons (HP:0007361)1.94162982
101Embryonal renal neoplasm (HP:0011794)1.94114264
102Choanal atresia (HP:0000453)1.93381271
103Atresia of the external auditory canal (HP:0000413)1.93285549
104Postnatal microcephaly (HP:0005484)1.93024908
105Cortical dysplasia (HP:0002539)1.92547728
106Abnormality of homocysteine metabolism (HP:0010919)1.90428178
107Homocystinuria (HP:0002156)1.90428178
108Basal cell carcinoma (HP:0002671)1.88364077
109Abnormality of the astrocytes (HP:0100707)1.88123459
110Astrocytoma (HP:0009592)1.88123459
111Neoplasm of the colon (HP:0100273)1.87695179
112Hepatocellular necrosis (HP:0001404)1.87096374
113Thrombocytosis (HP:0001894)1.86899248
114Premature ovarian failure (HP:0008209)1.86727271
115Deep philtrum (HP:0002002)1.86253563
116Squamous cell carcinoma (HP:0002860)1.86167030
117Aplasia/hypoplasia of the humerus (HP:0006507)1.85372836
118Lymphoma (HP:0002665)1.84702780
119Optic nerve coloboma (HP:0000588)1.84699786
120Sparse eyelashes (HP:0000653)1.84564177
121Facial cleft (HP:0002006)1.81999774
122Acute myeloid leukemia (HP:0004808)1.81663844
123Clubbing of toes (HP:0100760)1.81491464
124Abnormality of the umbilical cord (HP:0010881)1.81445975
125Duplicated collecting system (HP:0000081)1.81134737
126Lactic acidosis (HP:0003128)1.78709454
127Abnormalities of placenta or umbilical cord (HP:0001194)1.78038113
128Spastic diplegia (HP:0001264)1.77658060
129Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77614685
130Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.76614655
131Prominent nose (HP:0000448)1.73417797
132Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72613871
133Missing ribs (HP:0000921)1.72155117
134Hypoplasia of the pons (HP:0012110)1.72149200
135Stenosis of the external auditory canal (HP:0000402)1.71882870
136Neoplasm of striated muscle (HP:0009728)1.71396576
137Abnormality of the carotid arteries (HP:0005344)1.71162094
138Multiple enchondromatosis (HP:0005701)1.70454338
139High anterior hairline (HP:0009890)1.69884533
140Shoulder girdle muscle weakness (HP:0003547)1.69331101
141Increased nuchal translucency (HP:0010880)1.69225399
142Pelvic girdle muscle weakness (HP:0003749)1.68862094
143Secondary amenorrhea (HP:0000869)1.68749347
144Pancreatic islet-cell hyperplasia (HP:0004510)1.68309815
145Microglossia (HP:0000171)1.67673697
146Supernumerary bones of the axial skeleton (HP:0009144)1.65672843
147Microretrognathia (HP:0000308)1.64120903
148Cafe-au-lait spot (HP:0000957)1.63696417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.18051213
2WEE14.02413955
3BUB13.99686059
4EIF2AK13.44732267
5SRPK12.93946965
6ACVR1B2.83253849
7PLK42.59148604
8VRK22.53886327
9TSSK62.52303438
10MKNK12.45310260
11NEK22.35391764
12BRSK22.24896730
13EIF2AK32.23022922
14TTK2.22497597
15NEK12.18806862
16MKNK22.15531253
17PLK12.01323490
18PLK31.91675196
19CDK121.91453560
20NME21.72509917
21PASK1.70371383
22ATR1.68530231
23AURKB1.68302515
24STK161.66114691
25CDK71.61162025
26TAF11.60594079
27NME11.56002201
28RPS6KA41.54507129
29EPHA21.50580062
30VRK11.48983614
31DYRK31.34684836
32BRD41.34294230
33CHEK11.32650135
34TRIM281.31902446
35TGFBR11.30666869
36ZAK1.30011155
37CHEK21.27454545
38RPS6KB21.26825475
39EIF2AK21.16109259
40PBK1.13727054
41CDK41.12090724
42PIM11.11113481
43STK101.09362481
44MAP3K81.06025738
45TLK11.05702929
46ERBB41.05462598
47STK38L1.03527415
48SMG11.00738403
49ATM1.00376374
50AURKA0.99312200
51CCNB10.98658218
52PNCK0.95008018
53STK40.92918645
54BRSK10.89001504
55CDK20.87993927
56MAP3K120.84455881
57PIM20.81722128
58STK30.81126674
59ALK0.80953940
60MELK0.79157968
61PAK40.77434199
62TESK20.77339624
63CSNK2A20.76715917
64CLK10.74516295
65CDK60.69841471
66MST1R0.69628090
67CSNK2A10.69005491
68FLT30.68344229
69SCYL20.68163666
70LATS10.68145421
71CDK10.65890237
72IRAK40.64433182
73MAP2K30.63603685
74MST40.62504604
75RPS6KA50.61231131
76TEC0.61198281
77CHUK0.60929518
78MAP4K10.57396612
79CDK80.57381362
80EEF2K0.53029498
81NEK90.51755055
82TXK0.50778025
83JAK30.50202922
84LATS20.48832580
85IKBKB0.46483961
86MAP3K30.46223117
87FGFR10.45989014
88MAP3K140.44708191
89NLK0.43863767
90NUAK10.43196621
91ERBB30.43183085
92PAK10.43087737
93MARK30.42753972
94PRKCI0.40625303
95AKT20.40427476
96CSNK1E0.40015660
97STK240.38754374
98IRAK30.38360405
99MAPKAPK50.37219437
100CSNK1G10.35868299
101PAK20.34113082
102PRKDC0.33893409
103BMPR1B0.33885414
104KDR0.32889698
105MET0.32850508
106CDK90.32428752
107AKT30.31545352
108DAPK10.31511439
109RPS6KB10.31029246
110PLK20.30646124
111BTK0.29814064
112PDK20.29458352
113MAP3K100.29318112
114BCR0.29069389
115ZAP700.28728078
116CSNK1G30.28683325
117ILK0.28604175
118MAPK140.28568229
119YES10.28313863
120CSNK1A1L0.27404997
121BRAF0.26923638
122MAP3K50.26119007
123STK390.24316403
124RAF10.22893260
125TNIK0.20477426
126MTOR0.20064337

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.42709636
2* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.18771271
3Mismatch repair_Homo sapiens_hsa034303.89319237
4RNA polymerase_Homo sapiens_hsa030203.48031977
5Spliceosome_Homo sapiens_hsa030403.32776570
6RNA transport_Homo sapiens_hsa030133.31889597
7Proteasome_Homo sapiens_hsa030503.30340371
8Homologous recombination_Homo sapiens_hsa034402.99573393
9Ribosome_Homo sapiens_hsa030102.81886393
10Nucleotide excision repair_Homo sapiens_hsa034202.73093243
11One carbon pool by folate_Homo sapiens_hsa006702.69331881
12Cell cycle_Homo sapiens_hsa041102.67472672
13Base excision repair_Homo sapiens_hsa034102.66603255
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57010628
15Fanconi anemia pathway_Homo sapiens_hsa034602.30090525
16Pyrimidine metabolism_Homo sapiens_hsa002402.28767590
17Basal transcription factors_Homo sapiens_hsa030222.28651501
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.15183283
19Non-homologous end-joining_Homo sapiens_hsa034502.11689926
20RNA degradation_Homo sapiens_hsa030182.08128178
21mRNA surveillance pathway_Homo sapiens_hsa030151.88096336
22p53 signaling pathway_Homo sapiens_hsa041151.59791058
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50605013
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46817284
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45614975
26Epstein-Barr virus infection_Homo sapiens_hsa051691.38508131
27Pyruvate metabolism_Homo sapiens_hsa006201.33684855
28Purine metabolism_Homo sapiens_hsa002301.26377845
29Herpes simplex infection_Homo sapiens_hsa051681.20734364
30Systemic lupus erythematosus_Homo sapiens_hsa053221.16832212
31Antigen processing and presentation_Homo sapiens_hsa046121.13971904
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12616214
33Parkinsons disease_Homo sapiens_hsa050121.10962230
34Steroid biosynthesis_Homo sapiens_hsa001001.06938357
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06348770
36Oxidative phosphorylation_Homo sapiens_hsa001901.06338782
37Propanoate metabolism_Homo sapiens_hsa006401.04224551
38Viral carcinogenesis_Homo sapiens_hsa052031.01113527
39Allograft rejection_Homo sapiens_hsa053300.92107628
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86641384
41Legionellosis_Homo sapiens_hsa051340.85078590
42HTLV-I infection_Homo sapiens_hsa051660.82403581
43Selenocompound metabolism_Homo sapiens_hsa004500.77786721
44Oocyte meiosis_Homo sapiens_hsa041140.77105777
45Fatty acid elongation_Homo sapiens_hsa000620.74756677
46Graft-versus-host disease_Homo sapiens_hsa053320.74373314
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.73610150
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.73127401
49MicroRNAs in cancer_Homo sapiens_hsa052060.73105731
50N-Glycan biosynthesis_Homo sapiens_hsa005100.70111224
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69841222
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68435073
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68417738
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66243678
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66096972
56Measles_Homo sapiens_hsa051620.65088418
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62156239
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61782407
59Thyroid cancer_Homo sapiens_hsa052160.61605970
60Protein export_Homo sapiens_hsa030600.59578525
61Folate biosynthesis_Homo sapiens_hsa007900.58340769
62TGF-beta signaling pathway_Homo sapiens_hsa043500.58230548
63Small cell lung cancer_Homo sapiens_hsa052220.58123701
64Sulfur relay system_Homo sapiens_hsa041220.57923188
65Type I diabetes mellitus_Homo sapiens_hsa049400.55806299
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.55405837
67Vitamin B6 metabolism_Homo sapiens_hsa007500.55266947
68Biosynthesis of amino acids_Homo sapiens_hsa012300.55225890
69Lysine degradation_Homo sapiens_hsa003100.52329339
70Pentose phosphate pathway_Homo sapiens_hsa000300.52007022
71Apoptosis_Homo sapiens_hsa042100.51942685
72Primary immunodeficiency_Homo sapiens_hsa053400.51066484
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49784650
74Autoimmune thyroid disease_Homo sapiens_hsa053200.49476159
75Influenza A_Homo sapiens_hsa051640.48421564
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47980330
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47698265
78Alzheimers disease_Homo sapiens_hsa050100.46766580
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.46609293
80Metabolic pathways_Homo sapiens_hsa011000.46503452
81Asthma_Homo sapiens_hsa053100.45226220
82Fructose and mannose metabolism_Homo sapiens_hsa000510.44282523
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.44273838
84Hippo signaling pathway_Homo sapiens_hsa043900.41493473
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40681435
86Sulfur metabolism_Homo sapiens_hsa009200.40184246
87Basal cell carcinoma_Homo sapiens_hsa052170.39843117
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39211722
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.39048936
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38393462
91Hepatitis B_Homo sapiens_hsa051610.38102042
92Shigellosis_Homo sapiens_hsa051310.36407178
93Bladder cancer_Homo sapiens_hsa052190.35886792
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34186249
95Hematopoietic cell lineage_Homo sapiens_hsa046400.33997925
96Colorectal cancer_Homo sapiens_hsa052100.32133917
97Viral myocarditis_Homo sapiens_hsa054160.31967581
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30081577
99Glutathione metabolism_Homo sapiens_hsa004800.30045750
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.29765906
101Adherens junction_Homo sapiens_hsa045200.29570452
102Galactose metabolism_Homo sapiens_hsa000520.29152869
103Leishmaniasis_Homo sapiens_hsa051400.28623498
104Huntingtons disease_Homo sapiens_hsa050160.28077513
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27179319
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27116898
107Fatty acid metabolism_Homo sapiens_hsa012120.26755889
108Pathways in cancer_Homo sapiens_hsa052000.26251757
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25767337
110Arginine and proline metabolism_Homo sapiens_hsa003300.25766294
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24901182
112Prostate cancer_Homo sapiens_hsa052150.23826741
113HIF-1 signaling pathway_Homo sapiens_hsa040660.23122457
114Alcoholism_Homo sapiens_hsa050340.22993988
115Notch signaling pathway_Homo sapiens_hsa043300.22499586
116Vitamin digestion and absorption_Homo sapiens_hsa049770.21236093
117Acute myeloid leukemia_Homo sapiens_hsa052210.20995581
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20054544
119Chronic myeloid leukemia_Homo sapiens_hsa052200.19552312
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17830419
121Carbon metabolism_Homo sapiens_hsa012000.17521965
122T cell receptor signaling pathway_Homo sapiens_hsa046600.17167330
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16394894
124TNF signaling pathway_Homo sapiens_hsa046680.14854403
125Wnt signaling pathway_Homo sapiens_hsa043100.13926651
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12847509
127FoxO signaling pathway_Homo sapiens_hsa040680.12716615
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11550245
129Tight junction_Homo sapiens_hsa045300.11219414
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10320441
131Hedgehog signaling pathway_Homo sapiens_hsa043400.10185239
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.08902349
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08822258
134Malaria_Homo sapiens_hsa051440.07741000
135Peroxisome_Homo sapiens_hsa041460.06174130

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