GTF3C5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)9.01584301
2daunorubicin metabolic process (GO:0044597)9.01584301
3polyketide metabolic process (GO:0030638)9.01584301
4protein localization to kinetochore (GO:0034501)6.70254908
5aminoglycoside antibiotic metabolic process (GO:0030647)5.70837300
6somite rostral/caudal axis specification (GO:0032525)5.64808634
7maintenance of protein location in nucleus (GO:0051457)5.63775714
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.59583114
9regulation of nuclear cell cycle DNA replication (GO:0033262)5.53886670
10regulation of mammary gland epithelial cell proliferation (GO:0033599)5.48401404
11negative regulation of epidermis development (GO:0045683)5.47712053
12regulation of telomere maintenance via telomerase (GO:0032210)5.44160690
13mitotic sister chromatid segregation (GO:0000070)5.34172359
14negative regulation of telomerase activity (GO:0051974)5.19058131
15protein localization to chromosome, centromeric region (GO:0071459)5.13665770
16negative regulation of cell cycle G2/M phase transition (GO:1902750)5.12757703
17histone H4-K8 acetylation (GO:0043982)4.93208880
18histone H4-K5 acetylation (GO:0043981)4.93208880
19regulation of response to osmotic stress (GO:0047484)4.90685212
20peptidyl-arginine omega-N-methylation (GO:0035247)4.88926282
21DNA strand elongation involved in DNA replication (GO:0006271)4.83853648
22histone H4-K12 acetylation (GO:0043983)4.74808769
23DNA strand elongation (GO:0022616)4.72739589
24negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.62064222
25DNA replication-dependent nucleosome organization (GO:0034723)4.60513389
26DNA replication-dependent nucleosome assembly (GO:0006335)4.60513389
27DNA replication checkpoint (GO:0000076)4.60037251
28sister chromatid segregation (GO:0000819)4.56441540
29muscle organ morphogenesis (GO:0048644)4.50060621
30proline biosynthetic process (GO:0006561)4.50011068
31negative regulation of epidermal cell differentiation (GO:0045605)4.46344316
32heterochromatin organization (GO:0070828)4.44178264
33positive regulation of DNA-dependent DNA replication (GO:2000105)4.43056232
34telomere maintenance via semi-conservative replication (GO:0032201)4.27275405
35negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.20287088
36notochord development (GO:0030903)4.20188870
37rRNA methylation (GO:0031167)4.15737033
38regulation of MHC class I biosynthetic process (GO:0045343)4.10965343
39nuclear pore complex assembly (GO:0051292)4.10802316
40rRNA modification (GO:0000154)4.04029590
41regulation of cilium movement (GO:0003352)4.02414144
42negative regulation of telomere maintenance (GO:0032205)4.01070540
43histone arginine methylation (GO:0034969)3.98979980
44peptidyl-arginine methylation (GO:0018216)3.97285764
45peptidyl-arginine N-methylation (GO:0035246)3.97285764
46spliceosomal tri-snRNP complex assembly (GO:0000244)3.97162499
47regulation of translation in response to stress (GO:0043555)3.97071600
48regulation of translational fidelity (GO:0006450)3.93376158
49nuclear pore organization (GO:0006999)3.90043181
50chromatin assembly (GO:0031497)3.87071623
51primitive streak formation (GO:0090009)3.79340773
52protein-DNA complex disassembly (GO:0032986)3.76306633
53nucleosome disassembly (GO:0006337)3.76306633
54histone H4-K16 acetylation (GO:0043984)3.73979678
55cytidine metabolic process (GO:0046087)3.73584632
56cytidine catabolic process (GO:0006216)3.73584632
57cytidine deamination (GO:0009972)3.73584632
58ribosomal small subunit biogenesis (GO:0042274)3.71175997
59regulation of apoptotic process involved in morphogenesis (GO:1902337)3.68831434
60DNA unwinding involved in DNA replication (GO:0006268)3.67483866
61pre-miRNA processing (GO:0031054)3.67180798
62ribosome biogenesis (GO:0042254)3.63523199
63mitotic chromosome condensation (GO:0007076)3.61591057
64formation of translation preinitiation complex (GO:0001731)3.59179407
65DNA topological change (GO:0006265)3.59161026
66interferon-gamma production (GO:0032609)3.58820270
67DNA replication initiation (GO:0006270)3.55421805
68* rRNA transcription (GO:0009303)3.54164368
69branching involved in mammary gland duct morphogenesis (GO:0060444)3.53646069
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53175344
71negative regulation of DNA-templated transcription, elongation (GO:0032785)3.52481280
72viral mRNA export from host cell nucleus (GO:0046784)3.52269728
73cullin deneddylation (GO:0010388)3.48746208
74nucleoside transmembrane transport (GO:1901642)3.46562566
75maintenance of protein localization in organelle (GO:0072595)3.43956978
76ribonucleoprotein complex biogenesis (GO:0022613)3.43280019
77telomere maintenance via recombination (GO:0000722)3.41396388
78DNA duplex unwinding (GO:0032508)3.41303908
79ribosomal small subunit assembly (GO:0000028)3.40236106
80negative regulation of mRNA processing (GO:0050686)3.38903017
81DNA geometric change (GO:0032392)3.37719905
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37660283
83microtubule severing (GO:0051013)3.37293562
84intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.35465814
85L-serine metabolic process (GO:0006563)3.33754138
86intestinal epithelial cell development (GO:0060576)3.32843759
87quinone metabolic process (GO:1901661)3.32306212
88transcription from mitochondrial promoter (GO:0006390)3.32075855
89regulation of telomerase activity (GO:0051972)3.31952572
90regulation of chromatin binding (GO:0035561)3.30857201
91COPI coating of Golgi vesicle (GO:0048205)3.29723800
92Golgi transport vesicle coating (GO:0048200)3.29723800
93apoptotic DNA fragmentation (GO:0006309)3.28740509
94maturation of SSU-rRNA (GO:0030490)3.28350090
95mitotic recombination (GO:0006312)3.28239799
96viral transcription (GO:0019083)3.28193228
97RNA stabilization (GO:0043489)3.28053815
98mRNA stabilization (GO:0048255)3.28053815
99cardiovascular system development (GO:0072358)3.27158890
100nuclear envelope reassembly (GO:0031468)3.23223751
101mitotic nuclear envelope reassembly (GO:0007084)3.23223751
102establishment of integrated proviral latency (GO:0075713)3.22185674
103IMP biosynthetic process (GO:0006188)3.21250198
104negative regulation of RNA splicing (GO:0033119)3.19603659
105phenol-containing compound catabolic process (GO:0019336)3.18687574
106cell fate commitment involved in formation of primary germ layer (GO:0060795)3.17694873
107hormone catabolic process (GO:0042447)3.17070311
108positive regulation of protein deacetylation (GO:0090312)3.16867307
1093-UTR-mediated mRNA stabilization (GO:0070935)3.14668551
110retinoic acid receptor signaling pathway (GO:0048384)3.14521275
111protein complex localization (GO:0031503)3.14265337
112pseudouridine synthesis (GO:0001522)3.13520806
113pore complex assembly (GO:0046931)3.12572485
114regulation of telomere maintenance (GO:0032204)3.12319640
115protein deneddylation (GO:0000338)3.11014467
116trophectodermal cell differentiation (GO:0001829)3.10880411
117base-excision repair (GO:0006284)3.09714413
118regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08636512
119GDP-mannose metabolic process (GO:0019673)3.07160133
120negative regulation of mRNA metabolic process (GO:1903312)3.06293085
121proline metabolic process (GO:0006560)3.05927823
122regulation of gene silencing by miRNA (GO:0060964)3.05458356
123regulation of gene silencing by RNA (GO:0060966)3.05458356
124regulation of posttranscriptional gene silencing (GO:0060147)3.05458356
125mitochondrial fusion (GO:0008053)3.04777442
126regulation of DNA-dependent DNA replication (GO:0090329)3.04148682
127regulation of translational termination (GO:0006449)3.03901402
128negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.03019984
129bone trabecula formation (GO:0060346)3.01744281
130chromosome condensation (GO:0030261)3.01082956
131nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00802961
132translational termination (GO:0006415)2.99214711
133regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.98474974
134DNA damage response, detection of DNA damage (GO:0042769)2.98108273
135regulation of double-strand break repair via homologous recombination (GO:0010569)2.97120926
136dosage compensation (GO:0007549)2.96502609
137regulation of double-strand break repair (GO:2000779)2.95619467
138response to dietary excess (GO:0002021)2.95256246
139establishment of viral latency (GO:0019043)2.95135299
140mitotic metaphase plate congression (GO:0007080)2.94830901
141DNA conformation change (GO:0071103)2.94247319
142intracellular estrogen receptor signaling pathway (GO:0030520)2.90682736
143translational elongation (GO:0006414)2.90644311
144spindle assembly (GO:0051225)2.88981355
145folic acid-containing compound biosynthetic process (GO:0009396)2.88764006
146membrane disassembly (GO:0030397)2.88668644
147nuclear envelope disassembly (GO:0051081)2.88668644
148vitamin A metabolic process (GO:0006776)2.87278845
149protein localization to chromosome (GO:0034502)2.85780515
150maternal placenta development (GO:0001893)2.85520125
151intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.84231856
152negative regulation of gene silencing (GO:0060969)2.83826600
153regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.83190071
154mitochondrial DNA replication (GO:0006264)2.82889236
155pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.81496763
156snRNA metabolic process (GO:0016073)2.79636502
157mitotic nuclear envelope disassembly (GO:0007077)2.79041873
158telomere maintenance via telomere lengthening (GO:0010833)2.76561761
159ribosomal large subunit biogenesis (GO:0042273)2.76500975
160poly(A)+ mRNA export from nucleus (GO:0016973)2.75872664
161mitochondrial RNA metabolic process (GO:0000959)2.75640065
162pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75453332
163RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.75258602
164mRNA splicing, via spliceosome (GO:0000398)2.75258602
165protoporphyrinogen IX metabolic process (GO:0046501)2.75134317
166folic acid metabolic process (GO:0046655)2.74754187
167chromatin assembly or disassembly (GO:0006333)2.74456455
168mitochondrial DNA metabolic process (GO:0032042)2.72032911
169IMP metabolic process (GO:0046040)2.72020039
170translational initiation (GO:0006413)2.69988262
171nucleotide-excision repair, DNA gap filling (GO:0006297)2.68501451
172apoptotic process involved in morphogenesis (GO:0060561)2.68364438
173tRNA aminoacylation for protein translation (GO:0006418)2.68250383
174cellular protein complex localization (GO:0034629)2.67119328
175RNA splicing, via transesterification reactions (GO:0000375)2.66877481
176viral life cycle (GO:0019058)2.65709907
177regulation of DNA damage checkpoint (GO:2000001)2.64411708
178pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.64032549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.37803966
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.04431861
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.04431861
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.04431861
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.38228892
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.07001189
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.07885228
8* FOXM1_23109430_ChIP-Seq_U2OS_Human3.02346244
9* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01436032
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.54072064
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.50581332
12* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45830653
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.45703222
14* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.33970816
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.28498818
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19708264
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17294080
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12171279
19VDR_21846776_ChIP-Seq_THP-1_Human2.11199721
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11004450
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.01233929
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.00559090
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00227976
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95526957
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88437765
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84188299
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.82185664
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82113406
29MYC_22102868_ChIP-Seq_BL_Human1.79971327
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72638332
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71447498
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.70890414
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69780512
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68943891
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68594723
36DCP1A_22483619_ChIP-Seq_HELA_Human1.68539908
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68406562
38* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66972972
39NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.66014085
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.61897939
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61759079
42NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.59187313
43LXR_22292898_ChIP-Seq_THP-1_Human1.55745580
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51842587
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51820617
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.48468371
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48428755
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.48361844
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.47401593
50ZNF263_19887448_ChIP-Seq_K562_Human1.46235759
51IRF1_19129219_ChIP-ChIP_H3396_Human1.45252579
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43719594
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42598754
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40833236
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40562768
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40246251
57* P68_20966046_ChIP-Seq_HELA_Human1.39501022
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.32204133
59XRN2_22483619_ChIP-Seq_HELA_Human1.31739309
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30327608
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30149408
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28472395
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.27404571
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.25678653
65TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.25173476
66* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24952631
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24591363
68* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.24395498
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23933663
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.23546359
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.21770523
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21195686
73* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20204615
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19727189
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19649621
76OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18851139
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18804281
78NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18135074
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17483084
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16828690
81E2F1_17053090_ChIP-ChIP_MCF-7_Human1.15773682
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15446586
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15421058
84NANOG_18692474_ChIP-Seq_MESCs_Mouse1.15269833
85SOX2_18692474_ChIP-Seq_MESCs_Mouse1.14982418
86* FOXP3_21729870_ChIP-Seq_TREG_Human1.14978885
87RACK7_27058665_Chip-Seq_MCF-7_Human1.14292196
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13720957
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13434811
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.12211695
91FOXP1_21924763_ChIP-Seq_HESCs_Human1.10362928
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10320667
93KDM5A_27292631_Chip-Seq_BREAST_Human1.10069062
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09966954
95SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09619391
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06029887
97AR_21909140_ChIP-Seq_LNCAP_Human1.05531967
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05491731
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.05412526
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05163443
101NCOR1_26117541_ChIP-Seq_K562_Human1.05135035
102CIITA_25753668_ChIP-Seq_RAJI_Human1.03957310
103* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03902857
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03592904
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.03533623
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02833738
107TTF2_22483619_ChIP-Seq_HELA_Human1.02788628
108* GABP_19822575_ChIP-Seq_HepG2_Human1.01343475
109CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99956796
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.99285798
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99038078
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98952025
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98615152
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.97872198
115HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97757849
116KDM2B_26808549_Chip-Seq_DND41_Human0.97328869
117CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95927949
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95658284
119HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95646486
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95314688
121TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95189007
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95182169
123* CTCF_26484167_Chip-Seq_Bcells_Mouse0.94777172
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94510038
125PHF8_20622854_ChIP-Seq_HELA_Human0.94323225
126MAF_26560356_Chip-Seq_TH2_Human0.93220914
127* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91796458
128VDR_23849224_ChIP-Seq_CD4+_Human0.91083022
129* TCF7_22412390_ChIP-Seq_EML_Mouse0.90936653
130* GABP_17652178_ChIP-ChIP_JURKAT_Human0.88842530
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88358256
132E2F1_21310950_ChIP-Seq_MCF-7_Human0.88294740
133YY1_22570637_ChIP-Seq_MALME-3M_Human0.87833094
134THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87708482
135TP53_22127205_ChIP-Seq_IMR90_Human0.87344513
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87255874
137CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85777484
138NANOG_16518401_ChIP-PET_MESCs_Mouse0.82424564
139ELK3_25401928_ChIP-Seq_HUVEC_Human0.81673907
140TFEB_21752829_ChIP-Seq_HELA_Human0.81469716
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78750785
142SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78499808
143TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76942254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu3.82733063
2MP0006292_abnormal_olfactory_placode3.82208090
3MP0003011_delayed_dark_adaptation3.80638664
4MP0008057_abnormal_DNA_replication3.43912294
5MP0004957_abnormal_blastocyst_morpholog3.24821858
6MP0003890_abnormal_embryonic-extraembry3.23889342
7MP0005499_abnormal_olfactory_system3.13758446
8MP0005394_taste/olfaction_phenotype3.13758446
9MP0002254_reproductive_system_inflammat3.05269746
10MP0005075_abnormal_melanosome_morpholog2.76133843
11MP0003122_maternal_imprinting2.61116918
12MP0002653_abnormal_ependyma_morphology2.39136015
13MP0003121_genomic_imprinting2.32577282
14MP0004185_abnormal_adipocyte_glucose2.28162308
15MP0010030_abnormal_orbit_morphology2.27605979
16MP0004858_abnormal_nervous_system2.21042145
17MP0005451_abnormal_body_composition2.20932983
18MP0003077_abnormal_cell_cycle2.20603741
19MP0003111_abnormal_nucleus_morphology2.20540732
20MP0008995_early_reproductive_senescence2.19916285
21MP0000678_abnormal_parathyroid_gland2.17211898
22MP0010352_gastrointestinal_tract_polyps2.12415843
23MP0000537_abnormal_urethra_morphology2.08769592
24MP0010094_abnormal_chromosome_stability2.07457912
25MP0004233_abnormal_muscle_weight2.05712271
26MP0003705_abnormal_hypodermis_morpholog2.04645713
27MP0005257_abnormal_intraocular_pressure2.03031811
28MP0001672_abnormal_embryogenesis/_devel2.01552595
29MP0005380_embryogenesis_phenotype2.01552595
30MP0002332_abnormal_exercise_endurance2.00434945
31MP0003693_abnormal_embryo_hatching1.98028250
32MP0003123_paternal_imprinting1.97984610
33MP0009278_abnormal_bone_marrow1.91970762
34MP0002088_abnormal_embryonic_growth/wei1.86953090
35MP0003984_embryonic_growth_retardation1.86647971
36MP0000350_abnormal_cell_proliferation1.83791423
37MP0001293_anophthalmia1.79403207
38MP0006035_abnormal_mitochondrial_morpho1.74358552
39MP0003938_abnormal_ear_development1.73515016
40MP0008789_abnormal_olfactory_epithelium1.65617851
41MP0002822_catalepsy1.65474763
42MP0001849_ear_inflammation1.63761790
43MP0008961_abnormal_basal_metabolism1.63014451
44MP0005076_abnormal_cell_differentiation1.55952113
45MP0009672_abnormal_birth_weight1.55803493
46MP0002085_abnormal_embryonic_tissue1.55735859
47MP0002396_abnormal_hematopoietic_system1.54971415
48MP0002932_abnormal_joint_morphology1.52061933
49MP0008260_abnormal_autophagy1.51771359
50MP0008007_abnormal_cellular_replicative1.49258749
51MP0000049_abnormal_middle_ear1.48569380
52MP0001661_extended_life_span1.47688120
53MP0002127_abnormal_cardiovascular_syste1.47520792
54MP0005501_abnormal_skin_physiology1.46272714
55MP0002092_abnormal_eye_morphology1.43040469
56MP0008932_abnormal_embryonic_tissue1.42996246
57MP0001346_abnormal_lacrimal_gland1.41214046
58MP0002086_abnormal_extraembryonic_tissu1.38832142
59MP0002084_abnormal_developmental_patter1.37362977
60MP0002277_abnormal_respiratory_mucosa1.36069303
61MP0001730_embryonic_growth_arrest1.35162237
62MP0003283_abnormal_digestive_organ1.34580990
63MP0001529_abnormal_vocalization1.34487740
64MP0000428_abnormal_craniofacial_morphol1.31756093
65MP0009333_abnormal_splenocyte_physiolog1.27511161
66MP0000490_abnormal_crypts_of1.26482319
67MP0000003_abnormal_adipose_tissue1.23906900
68MP0002233_abnormal_nose_morphology1.23175871
69MP0001727_abnormal_embryo_implantation1.21237857
70MP0004197_abnormal_fetal_growth/weight/1.20033168
71MP0001697_abnormal_embryo_size1.19497658
72MP0002877_abnormal_melanocyte_morpholog1.17238257
73MP0000313_abnormal_cell_death1.16875885
74MP0004133_heterotaxia1.16560116
75MP0002080_prenatal_lethality1.15073852
76MP0002089_abnormal_postnatal_growth/wei1.14845188
77MP0008058_abnormal_DNA_repair1.14274475
78MP0003183_abnormal_peptide_metabolism1.13230406
79MP0002114_abnormal_axial_skeleton1.11368177
80MP0003119_abnormal_digestive_system1.10021815
81MP0003935_abnormal_craniofacial_develop1.09186929
82MP0002132_abnormal_respiratory_system1.08159972
83MP0003786_premature_aging1.06993942
84MP0005058_abnormal_lysosome_morphology1.06848240
85MP0000762_abnormal_tongue_morphology1.05464308
86MP0000432_abnormal_head_morphology1.04648121
87MP0001348_abnormal_lacrimal_gland1.03405314
88MP0000681_abnormal_thyroid_gland1.01335786
89MP0003315_abnormal_perineum_morphology1.01284667
90MP0003755_abnormal_palate_morphology0.99086201
91MP0000703_abnormal_thymus_morphology0.97983394
92MP0002210_abnormal_sex_determination0.94942667
93MP0002970_abnormal_white_adipose0.93203852
94MP0006082_CNS_inflammation0.93198137
95MP0005266_abnormal_metabolism0.92233031
96MP0005391_vision/eye_phenotype0.89471221
97MP0002163_abnormal_gland_morphology0.88966931
98MP0003937_abnormal_limbs/digits/tail_de0.88534478
99MP0008770_decreased_survivor_rate0.88400862
100MP0000750_abnormal_muscle_regeneration0.88202569
101MP0002249_abnormal_larynx_morphology0.86944889
102MP0009703_decreased_birth_body0.86181010
103MP0002751_abnormal_autonomic_nervous0.85992849
104MP0002160_abnormal_reproductive_system0.85766908
105MP0002116_abnormal_craniofacial_bone0.83885324
106MP0009379_abnormal_foot_pigmentation0.82775682
107MP0005248_abnormal_Harderian_gland0.82388054
108MP0002925_abnormal_cardiovascular_devel0.81769704
109MP0000747_muscle_weakness0.80869246
110MP0005508_abnormal_skeleton_morphology0.80750723
111MP0004808_abnormal_hematopoietic_stem0.79689868
112MP0000467_abnormal_esophagus_morphology0.79052849
113MP0010307_abnormal_tumor_latency0.77957412
114MP0001286_abnormal_eye_development0.76650659
115MP0005083_abnormal_biliary_tract0.75228226
116MP0003385_abnormal_body_wall0.75116625
117MP0009697_abnormal_copulation0.75115040
118MP0002019_abnormal_tumor_incidence0.74859678
119MP0000358_abnormal_cell_content/0.74778324
120MP0003806_abnormal_nucleotide_metabolis0.74167995
121MP0000013_abnormal_adipose_tissue0.73816441
122MP0006036_abnormal_mitochondrial_physio0.71733584
123MP0001188_hyperpigmentation0.70735883
124MP0002111_abnormal_tail_morphology0.70137545
125MP0003115_abnormal_respiratory_system0.69972565
126MP0004147_increased_porphyrin_level0.68636288
127MP0001929_abnormal_gametogenesis0.67156013
128MP0005023_abnormal_wound_healing0.66754860
129MP0005384_cellular_phenotype0.66729958
130MP0002796_impaired_skin_barrier0.66712323
131MP0002722_abnormal_immune_system0.65993157
132MP0002098_abnormal_vibrissa_morphology0.65160118
133MP0000566_synostosis0.64922785
134MP0003763_abnormal_thymus_physiology0.64293201
135MP0001340_abnormal_eyelid_morphology0.64108550
136MP0003861_abnormal_nervous_system0.63764838
137MP0003137_abnormal_impulse_conducting0.62719820
138MP0001145_abnormal_male_reproductive0.62409589
139MP0003942_abnormal_urinary_system0.61752187
140MP0002081_perinatal_lethality0.60725189
141MP0003787_abnormal_imprinting0.60534658
142MP0004381_abnormal_hair_follicle0.59347065
143MP0004043_abnormal_pH_regulation0.58690377
144MP0002697_abnormal_eye_size0.55537657
145MP0002269_muscular_atrophy0.54431307

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.76432970
2Multiple enchondromatosis (HP:0005701)4.94827488
3Hepatoblastoma (HP:0002884)4.84377704
4Hypochromic microcytic anemia (HP:0004840)4.80654408
5Ependymoma (HP:0002888)4.67629086
6Rib fusion (HP:0000902)4.54133150
7Abnormality of the lower motor neuron (HP:0002366)4.51521694
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.13442816
9Neoplasm of striated muscle (HP:0009728)3.87660379
10Rhabdomyosarcoma (HP:0002859)3.83686503
11Reticulocytopenia (HP:0001896)3.78606498
12Chromsome breakage (HP:0040012)3.63578186
13Nephroblastoma (Wilms tumor) (HP:0002667)3.50071015
14Abnormality of cells of the erythroid lineage (HP:0012130)3.40597033
15Abnormality of cochlea (HP:0000375)3.37816843
16Abnormality of reticulocytes (HP:0004312)3.35242959
17Embryonal renal neoplasm (HP:0011794)3.22298967
18Abnormality of the astrocytes (HP:0100707)3.21257693
19Astrocytoma (HP:0009592)3.21257693
20Abnormal number of erythroid precursors (HP:0012131)3.18386539
21Reticulocytosis (HP:0001923)3.14702336
22Hyperacusis (HP:0010780)3.12898802
23Bifid tongue (HP:0010297)3.08638174
24Hypoplasia of the fovea (HP:0007750)3.00849714
25Aplasia/Hypoplasia of the fovea (HP:0008060)3.00849714
26Trismus (HP:0000211)2.99982931
27Broad distal phalanx of finger (HP:0009836)2.97145496
28High anterior hairline (HP:0009890)2.96137584
29Birth length less than 3rd percentile (HP:0003561)2.95427893
30Rectovaginal fistula (HP:0000143)2.94036954
31Rectal fistula (HP:0100590)2.94036954
32Cholecystitis (HP:0001082)2.90685590
33Abnormal gallbladder physiology (HP:0012438)2.90685590
34Abnormal lung lobation (HP:0002101)2.88562414
35Amyotrophic lateral sclerosis (HP:0007354)2.85077455
36Fused cervical vertebrae (HP:0002949)2.84736526
37Aplasia/hypoplasia of the humerus (HP:0006507)2.83172777
38Truncus arteriosus (HP:0001660)2.83003859
39Meckel diverticulum (HP:0002245)2.81293328
40Partial duplication of thumb phalanx (HP:0009944)2.80261787
41Abnormality of the salivary glands (HP:0010286)2.76428262
42Preauricular skin tag (HP:0000384)2.73054289
43Short humerus (HP:0005792)2.69672112
44Intestinal fistula (HP:0100819)2.69340536
45Squamous cell carcinoma (HP:0002860)2.66912849
46Morphological abnormality of the inner ear (HP:0011390)2.66697850
47Abnormality of the ileum (HP:0001549)2.66550775
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.66162190
49Supernumerary spleens (HP:0009799)2.65109651
50Ragged-red muscle fibers (HP:0003200)2.64692254
51Impulsivity (HP:0100710)2.61606795
52Pendular nystagmus (HP:0012043)2.58742944
53Testicular atrophy (HP:0000029)2.58277901
54Renal duplication (HP:0000075)2.54971050
55Reduced antithrombin III activity (HP:0001976)2.54324952
56Partial duplication of the phalanx of hand (HP:0009999)2.51197647
57Hyperinsulinemic hypoglycemia (HP:0000825)2.51091295
58Vaginal fistula (HP:0004320)2.50651657
59Glioma (HP:0009733)2.47555619
60Anomalous pulmonary venous return (HP:0010772)2.46486408
61Myopathic facies (HP:0002058)2.45822135
62Proximal placement of thumb (HP:0009623)2.45712652
63Short 5th finger (HP:0009237)2.44152248
64Abnormality of chromosome segregation (HP:0002916)2.44023891
65Skin tags (HP:0010609)2.43827295
66Progressive muscle weakness (HP:0003323)2.43282459
67Insomnia (HP:0100785)2.42126044
68Horseshoe kidney (HP:0000085)2.40869035
69Microretrognathia (HP:0000308)2.40196344
70Abnormality of DNA repair (HP:0003254)2.39009723
71Medulloblastoma (HP:0002885)2.35022223
72Abnormal cartilage morphology (HP:0002763)2.33470616
73Glossoptosis (HP:0000162)2.32649170
74Abnormality of glycolysis (HP:0004366)2.31852593
75Duodenal stenosis (HP:0100867)2.31198957
76Small intestinal stenosis (HP:0012848)2.31198957
77Shawl scrotum (HP:0000049)2.30804375
78Pallor (HP:0000980)2.29633763
79Deviation of the thumb (HP:0009603)2.28072744
80Cortical dysplasia (HP:0002539)2.26977757
81Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.25414874
82Absent epiphyses (HP:0010577)2.25414874
83Preauricular pit (HP:0004467)2.23659280
84Periauricular skin pits (HP:0100277)2.23659280
85Abnormality of the phalanges of the hallux (HP:0010057)2.21760421
86Abnormality of the fovea (HP:0000493)2.20655802
87Hypochromic anemia (HP:0001931)2.19836491
88Facial cleft (HP:0002006)2.19538127
89Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.17655122
90Breast hypoplasia (HP:0003187)2.17603701
91Aplasia/Hypoplasia of the sternum (HP:0006714)2.17342394
92Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17305590
93Generalized hypotonia (HP:0001290)2.17289671
94Nasal polyposis (HP:0100582)2.17076673
95Atrophy/Degeneration involving motor neurons (HP:0007373)2.14960510
96Abnormality of the pulmonary veins (HP:0011718)2.13485755
97Atresia of the external auditory canal (HP:0000413)2.12475591
98Tongue fasciculations (HP:0001308)2.12236110
99Horizontal nystagmus (HP:0000666)2.11320783
100Distal lower limb amyotrophy (HP:0008944)2.10833201
101Rough bone trabeculation (HP:0100670)2.07593386
102Abnormality of the fetal cardiovascular system (HP:0010948)2.06967586
103Abnormal umbilical cord blood vessels (HP:0011403)2.06967586
104Single umbilical artery (HP:0001195)2.06967586
105Neoplasm of the heart (HP:0100544)2.04537567
106Large earlobe (HP:0009748)2.04051902
107Ureteral duplication (HP:0000073)2.03429906
108Selective tooth agenesis (HP:0001592)2.01446846
109Villous atrophy (HP:0011473)2.01114174
110Abnormality of small intestinal villus morphology (HP:0011472)2.01114174
111Malignant neoplasm of the central nervous system (HP:0100836)2.00140591
112Progressive external ophthalmoplegia (HP:0000590)2.00062376
113Abnormality of the musculature of the hand (HP:0001421)1.99433892
114Achilles tendon contracture (HP:0001771)1.99428011
115Poikiloderma (HP:0001029)1.99287052
116Prominent occiput (HP:0000269)1.97937847
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.97776586
118Microvesicular hepatic steatosis (HP:0001414)1.97726692
119Hypoparathyroidism (HP:0000829)1.97610618
120Pseudobulbar signs (HP:0002200)1.96087804
121Abnormality of the umbilical cord (HP:0010881)1.94827167
122Nasolacrimal duct obstruction (HP:0000579)1.93913281
123Aplasia/Hypoplasia of the patella (HP:0006498)1.93332455
124Hand muscle atrophy (HP:0009130)1.93256891
125Premature ovarian failure (HP:0008209)1.92983173
126Muscle fibrillation (HP:0010546)1.92806001
127Tetraplegia (HP:0002445)1.92772604
128Deep palmar crease (HP:0006191)1.90948785
129Increased connective tissue (HP:0009025)1.88483904
130Sloping forehead (HP:0000340)1.88440771
131Hyperthyroidism (HP:0000836)1.87835049
132Patellar aplasia (HP:0006443)1.87754283
133Abnormal large intestine physiology (HP:0012700)1.86763067
134Increased nuchal translucency (HP:0010880)1.86185102
135Aplasia/Hypoplasia of the macula (HP:0008059)1.86064767
136Abnormality of the duodenum (HP:0002246)1.86017980
137Bowel incontinence (HP:0002607)1.85809386
138Cholelithiasis (HP:0001081)1.85719889
139Hypopigmentation of the fundus (HP:0007894)1.85016419
140Short thumb (HP:0009778)1.84447293
141Abnormality of the renal collecting system (HP:0004742)1.84283860
142Hypergonadotropic hypogonadism (HP:0000815)1.84260812
143Optic nerve coloboma (HP:0000588)1.83952550
144Duplicated collecting system (HP:0000081)1.83947668
145Abnormality of the preputium (HP:0100587)1.83738881
146Abnormality of the aortic arch (HP:0012303)1.82904330
147Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82827714
148Pointed chin (HP:0000307)1.82489274
149Vertebral fusion (HP:0002948)1.82197601
150Increased serum pyruvate (HP:0003542)1.81520631
151Abnormality of the calcaneus (HP:0008364)1.81468918
152Embryonal neoplasm (HP:0002898)1.81449110
153Duplication of thumb phalanx (HP:0009942)1.81301760
154Type I transferrin isoform profile (HP:0003642)1.80879430
155Myelodysplasia (HP:0002863)1.80339159
156Long palpebral fissure (HP:0000637)1.80295342
157Acute lymphatic leukemia (HP:0006721)1.80108088
158Abnormality of the carotid arteries (HP:0005344)1.79997653
159Trigonocephaly (HP:0000243)1.79150952
160Centrally nucleated skeletal muscle fibers (HP:0003687)1.78858349
161Hypertensive crisis (HP:0100735)1.78305958
162Seborrheic dermatitis (HP:0001051)1.73655102
163Overriding aorta (HP:0002623)1.73573324
164Entropion (HP:0000621)1.72942875
165Tetralogy of Fallot (HP:0001636)1.72931637
166Metaphyseal cupping (HP:0003021)1.69282904
167Disproportionate tall stature (HP:0001519)1.68092063
168Abnormality of the columella (HP:0009929)1.67831048
169Aplasia/Hypoplasia of the thymus (HP:0010515)1.65740806
170Ectopic kidney (HP:0000086)1.65733596
171Self-mutilation (HP:0000742)1.65068610
172Ulnar bowing (HP:0003031)1.65022922
173Macrocytic anemia (HP:0001972)1.63736980
174Spastic diplegia (HP:0001264)1.61372595
175Cerebral hypomyelination (HP:0006808)1.60240281
176Diastasis recti (HP:0001540)1.60181217
177Abnormality of subcutaneous fat tissue (HP:0001001)1.59993873
178Abnormality of the Achilles tendon (HP:0005109)1.59766052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.29464396
2ERN14.50017209
3GRK54.46940899
4SMG13.97026547
5GRK63.83773221
6GRK13.08692964
7NME23.05963438
8TTK2.97198696
9VRK22.95295801
10CSF1R2.61329907
11ADRBK22.58488119
12STK102.30166048
13TGFBR22.22819955
14TYRO32.21073594
15BUB12.16750113
16BCKDK2.15996050
17MAPK72.04782248
18CDK72.00943874
19MATK1.93980879
20KDR1.87490301
21GRK71.75461301
22MAP3K101.69066096
23IRAK31.65156861
24MOS1.63354168
25CDC71.63031710
26WNK11.61591227
27PAK41.59194843
28PBK1.54529873
29PLK11.53539653
30PIM21.49802919
31EIF2AK11.46513573
32CHEK21.43637668
33PRPF4B1.41137121
34WEE11.39088674
35NEK21.33538707
36EPHA21.33153635
37MAP3K111.20172947
38CAMK41.19372354
39PRKG21.17224471
40CDK91.12304893
41SCYL21.09449883
42MAP2K31.09030378
43CDK191.07693078
44CHEK11.06176531
45STK161.02538148
46RPS6KB21.02148181
47ARAF0.97438771
48HIPK20.97023298
49NTRK10.95284940
50PKN20.93842070
51AKT20.93430182
52MARK20.92524827
53MAPK110.90467228
54AKT30.88872832
55SIK20.88135489
56AURKA0.86229269
57CLK10.84838979
58CDK40.84489674
59BRAF0.84093840
60ZAK0.83060807
61TESK10.81537709
62ALK0.81279068
63EEF2K0.80636320
64ADRBK10.78592215
65MTOR0.78379004
66DYRK30.78332623
67NME10.77169000
68PRKD20.76444402
69AURKB0.76423119
70FGFR30.76362541
71MAP2K20.73114979
72LATS20.72309957
73NEK10.68604687
74CDK20.67625317
75TLK10.67036216
76VRK10.66849977
77SRPK10.62593646
78PLK40.61778720
79FGFR40.61711212
80ILK0.60893398
81PAK10.60863587
82PRKCI0.59366514
83RPS6KA40.59248001
84CSNK1G30.59164520
85TSSK60.59015086
86DAPK10.58635381
87LRRK20.58345540
88MAP2K60.57609747
89PRKD30.56801738
90CSK0.56622448
91RPS6KA50.56606494
92IRAK20.56140351
93BRSK20.55974415
94PTK60.55734368
95EIF2AK20.55266994
96RAF10.54089885
97CDK60.53907874
98ATR0.52738770
99MAPKAPK30.52726340
100TESK20.51344690
101BRSK10.50564304
102KSR20.50516468
103ATM0.49941808
104ICK0.47227522
105RPS6KL10.47127939
106RPS6KC10.47127939
107TTN0.47116348
108MAP2K40.46901241
109CDK10.44559287
110BRD40.44368808
111MAPK120.42851571
112DYRK20.42341902
113RPS6KA10.42114994
114ACVR1B0.41740906
115DAPK30.41631986
116BMX0.41408180
117MAP4K10.40754157
118MAP3K70.40145025
119TRIB30.36918316
120PTK20.35610918
121CSNK1E0.34079628
122ERBB20.33830599
123CDK80.33407146
124CHUK0.32252074
125ITK0.31105940
126MAP3K80.30442398
127MAPK100.28380400
128PASK0.28220394
129PDGFRA0.27245811
130CDK150.27079712
131MAPK140.26805111
132CDK11A0.26368984
133GSK3B0.26028042
134STK30.25931363
135MAPK10.25359229
136TAOK20.24972661
137IKBKB0.24909611
138CDK180.24142197
139MAPKAPK20.23500124
140STK40.22912327
141PRKCD0.19726907
142PIM10.19633737
143DYRK1A0.18917949
144IGF1R0.18479564
145DYRK1B0.17610340
146MAPK40.17419465
147RIPK10.16576505
148AKT10.15113315
149CDK140.14933075
150SIK10.14592585

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.12419366
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.47068809
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.31457241
4DNA replication_Homo sapiens_hsa030303.22540888
5Fructose and mannose metabolism_Homo sapiens_hsa000512.85057898
6Mismatch repair_Homo sapiens_hsa034302.66835703
7RNA transport_Homo sapiens_hsa030132.66499721
8Cell cycle_Homo sapiens_hsa041102.37618859
9Fanconi anemia pathway_Homo sapiens_hsa034602.29523520
10Homologous recombination_Homo sapiens_hsa034402.22993669
11Spliceosome_Homo sapiens_hsa030402.13040826
12Base excision repair_Homo sapiens_hsa034102.13031567
13One carbon pool by folate_Homo sapiens_hsa006702.02251194
14Galactose metabolism_Homo sapiens_hsa000521.96147812
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95134600
16mRNA surveillance pathway_Homo sapiens_hsa030151.90613114
17Arachidonic acid metabolism_Homo sapiens_hsa005901.78202305
18Ribosome_Homo sapiens_hsa030101.72850624
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.58022198
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56406470
21RNA degradation_Homo sapiens_hsa030181.49259579
22RNA polymerase_Homo sapiens_hsa030201.48895604
23p53 signaling pathway_Homo sapiens_hsa041151.41757805
24mTOR signaling pathway_Homo sapiens_hsa041501.36835191
25Linoleic acid metabolism_Homo sapiens_hsa005911.35601799
26Thyroid cancer_Homo sapiens_hsa052161.35101819
27Nucleotide excision repair_Homo sapiens_hsa034201.33439448
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28772543
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28281355
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26271229
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26221732
32Systemic lupus erythematosus_Homo sapiens_hsa053221.25512195
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20460421
34Pyrimidine metabolism_Homo sapiens_hsa002401.20359536
35Alcoholism_Homo sapiens_hsa050341.19791214
36Basal cell carcinoma_Homo sapiens_hsa052171.19401748
37N-Glycan biosynthesis_Homo sapiens_hsa005101.12823324
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12075798
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11011911
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06781560
41Folate biosynthesis_Homo sapiens_hsa007901.06184054
42Chronic myeloid leukemia_Homo sapiens_hsa052201.00496888
43Basal transcription factors_Homo sapiens_hsa030220.95562780
44MicroRNAs in cancer_Homo sapiens_hsa052060.94566444
45Hedgehog signaling pathway_Homo sapiens_hsa043400.94457170
46Notch signaling pathway_Homo sapiens_hsa043300.92578470
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92430264
48Hippo signaling pathway_Homo sapiens_hsa043900.86678637
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85624696
50Pentose phosphate pathway_Homo sapiens_hsa000300.83253074
51Herpes simplex infection_Homo sapiens_hsa051680.81602115
52Vibrio cholerae infection_Homo sapiens_hsa051100.80223069
53Pathways in cancer_Homo sapiens_hsa052000.78961729
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74167154
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74158533
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71437982
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71034549
58Non-homologous end-joining_Homo sapiens_hsa034500.70618142
59HTLV-I infection_Homo sapiens_hsa051660.70062501
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.69753834
61Acute myeloid leukemia_Homo sapiens_hsa052210.68533092
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68197388
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68005890
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.66380364
65Viral carcinogenesis_Homo sapiens_hsa052030.65474655
66Apoptosis_Homo sapiens_hsa042100.65439216
67Arginine biosynthesis_Homo sapiens_hsa002200.64006633
68Bladder cancer_Homo sapiens_hsa052190.62316987
69Non-small cell lung cancer_Homo sapiens_hsa052230.61631349
70Arginine and proline metabolism_Homo sapiens_hsa003300.60837549
71Inositol phosphate metabolism_Homo sapiens_hsa005620.59977968
72Other glycan degradation_Homo sapiens_hsa005110.59927504
73Biosynthesis of amino acids_Homo sapiens_hsa012300.59588667
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59369717
75Ovarian steroidogenesis_Homo sapiens_hsa049130.58548839
76Sulfur relay system_Homo sapiens_hsa041220.56968039
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56680039
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55836103
79Fatty acid elongation_Homo sapiens_hsa000620.55438860
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54654613
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54595466
82Pyruvate metabolism_Homo sapiens_hsa006200.53139744
83Small cell lung cancer_Homo sapiens_hsa052220.52144122
84Colorectal cancer_Homo sapiens_hsa052100.51854268
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51576871
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.51028289
87Selenocompound metabolism_Homo sapiens_hsa004500.49234359
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48871068
89Huntingtons disease_Homo sapiens_hsa050160.48436371
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48279139
91Oocyte meiosis_Homo sapiens_hsa041140.48024567
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45370897
93Shigellosis_Homo sapiens_hsa051310.45263286
94Wnt signaling pathway_Homo sapiens_hsa043100.43892653
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43139359
96Endometrial cancer_Homo sapiens_hsa052130.42993286
97Proteasome_Homo sapiens_hsa030500.41825830
98Protein digestion and absorption_Homo sapiens_hsa049740.41817327
99Proteoglycans in cancer_Homo sapiens_hsa052050.41584936
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40924342
101Epstein-Barr virus infection_Homo sapiens_hsa051690.40133717
102Pancreatic cancer_Homo sapiens_hsa052120.39964521
103Insulin signaling pathway_Homo sapiens_hsa049100.39198450
104Purine metabolism_Homo sapiens_hsa002300.38802685
105Glioma_Homo sapiens_hsa052140.38227481
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38183197
107AMPK signaling pathway_Homo sapiens_hsa041520.36630032
108Steroid biosynthesis_Homo sapiens_hsa001000.35668682
109Metabolic pathways_Homo sapiens_hsa011000.35666754
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35061271
111Regulation of autophagy_Homo sapiens_hsa041400.34509486
112Hepatitis B_Homo sapiens_hsa051610.34051704
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33293196
114VEGF signaling pathway_Homo sapiens_hsa043700.33061650
115Rap1 signaling pathway_Homo sapiens_hsa040150.32582562
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.32003195
117Choline metabolism in cancer_Homo sapiens_hsa052310.31621718
118Glutathione metabolism_Homo sapiens_hsa004800.30822568
119Carbon metabolism_Homo sapiens_hsa012000.30611504
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30355588
121Primary immunodeficiency_Homo sapiens_hsa053400.29910278
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29807059
123Parkinsons disease_Homo sapiens_hsa050120.28986463
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.27921078
125Ether lipid metabolism_Homo sapiens_hsa005650.27491325
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27460374
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.27203823
128Antigen processing and presentation_Homo sapiens_hsa046120.26334736
129Lysine degradation_Homo sapiens_hsa003100.25755227
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.25281394
131Tight junction_Homo sapiens_hsa045300.24133371
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22833127
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22074464
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.21618997

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