GTF2IP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)4.25533736
2regulation of synaptic vesicle exocytosis (GO:2000300)4.23893902
3layer formation in cerebral cortex (GO:0021819)4.00575911
4synaptic vesicle maturation (GO:0016188)3.89769319
5cerebellar granule cell differentiation (GO:0021707)3.63453636
6presynaptic membrane assembly (GO:0097105)3.63204356
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.62473061
8L-amino acid import (GO:0043092)3.60217401
9sodium ion export (GO:0071436)3.55819782
10locomotory exploration behavior (GO:0035641)3.53263101
11amino acid import (GO:0043090)3.50439962
12apical protein localization (GO:0045176)3.46426294
13cytoskeletal anchoring at plasma membrane (GO:0007016)3.39126567
14vocalization behavior (GO:0071625)3.37004751
15postsynaptic membrane organization (GO:0001941)3.33041084
16glutamate secretion (GO:0014047)3.31106891
17planar cell polarity pathway involved in neural tube closure (GO:0090179)3.29918809
18presynaptic membrane organization (GO:0097090)3.29773770
19paraxial mesoderm development (GO:0048339)3.26846030
20regulation of synaptic vesicle transport (GO:1902803)3.18447625
21cell communication by electrical coupling (GO:0010644)3.15838420
22regulation of neuronal synaptic plasticity (GO:0048168)3.15720408
23regulation of ARF protein signal transduction (GO:0032012)3.15569815
24cellular potassium ion homeostasis (GO:0030007)3.10927536
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09539665
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.04721784
27negative regulation of dendrite morphogenesis (GO:0050774)3.01464879
28neuron cell-cell adhesion (GO:0007158)2.98764148
29exploration behavior (GO:0035640)2.98566873
30establishment of nucleus localization (GO:0040023)2.97566853
31embryonic retina morphogenesis in camera-type eye (GO:0060059)2.92785189
32ionotropic glutamate receptor signaling pathway (GO:0035235)2.87575457
33cell migration in hindbrain (GO:0021535)2.87099866
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83928319
35positive regulation of dendritic spine morphogenesis (GO:0061003)2.80538669
36regulation of long-term neuronal synaptic plasticity (GO:0048169)2.78424521
37neuronal ion channel clustering (GO:0045161)2.76811546
38regulation of NFAT protein import into nucleus (GO:0051532)2.75956718
39synaptic vesicle exocytosis (GO:0016079)2.74494331
40neurotransmitter-gated ion channel clustering (GO:0072578)2.73408459
41neuron recognition (GO:0008038)2.72678887
42neuromuscular process controlling balance (GO:0050885)2.71203178
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.69851344
44G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.68957791
45mating behavior (GO:0007617)2.68003660
46axonal fasciculation (GO:0007413)2.64596722
47suckling behavior (GO:0001967)2.59892107
48axon ensheathment in central nervous system (GO:0032291)2.56625579
49central nervous system myelination (GO:0022010)2.56625579
50neurotransmitter secretion (GO:0007269)2.54337399
51asymmetric protein localization (GO:0008105)2.53453528
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.51127554
53dendrite morphogenesis (GO:0048813)2.50559948
54cellular response to prostaglandin stimulus (GO:0071379)2.49975686
55negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.45898079
56regulation of glutamate receptor signaling pathway (GO:1900449)2.44966449
57innervation (GO:0060384)2.42119292
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.42093585
59embryonic camera-type eye morphogenesis (GO:0048596)2.41068206
60pyrimidine nucleobase catabolic process (GO:0006208)2.40021902
61convergent extension (GO:0060026)2.38886315
62potassium ion homeostasis (GO:0055075)2.38091028
63notochord development (GO:0030903)2.37370307
64ectodermal placode formation (GO:0060788)2.35917527
65Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.33891899
66regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.33605749
67establishment of mitochondrion localization (GO:0051654)2.33233567
68establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.33142970
69regulation of synaptic plasticity (GO:0048167)2.33093810
70central nervous system projection neuron axonogenesis (GO:0021952)2.31720242
71regulation of Rac protein signal transduction (GO:0035020)2.31454094
72clathrin coat assembly (GO:0048268)2.28356406
73neuron projection regeneration (GO:0031102)2.27098176
74axon extension (GO:0048675)2.26910027
75regulation of catenin import into nucleus (GO:0035412)2.26740483
76embryonic foregut morphogenesis (GO:0048617)2.26602098
77regulation of nucleobase-containing compound transport (GO:0032239)2.26342954
78astrocyte development (GO:0014002)2.26216249
79regulation of establishment of planar polarity (GO:0090175)2.25662285
80developmental cell growth (GO:0048588)2.25189175
81cellular response to monoamine stimulus (GO:0071868)2.24701123
82cellular response to catecholamine stimulus (GO:0071870)2.24701123
83establishment or maintenance of apical/basal cell polarity (GO:0035088)2.24593779
84establishment or maintenance of bipolar cell polarity (GO:0061245)2.24593779
85histone H3-K9 demethylation (GO:0033169)2.24420397
86regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.24416378
87regulation of dendritic spine morphogenesis (GO:0061001)2.23549606
88peptidyl-tyrosine autophosphorylation (GO:0038083)2.23307537
89regulation of dendrite morphogenesis (GO:0048814)2.22667174
90adherens junction assembly (GO:0034333)2.22585800
91long-term memory (GO:0007616)2.21849499
92nerve growth factor signaling pathway (GO:0038180)2.21528787
93positive regulation of catenin import into nucleus (GO:0035413)2.21338655
94peptidyl-threonine phosphorylation (GO:0018107)2.20575242
95positive regulation of glucose transport (GO:0010828)2.20060221
96negative regulation of fibroblast apoptotic process (GO:2000270)2.19766568
97membrane assembly (GO:0071709)2.19377032
98peptidyl-threonine modification (GO:0018210)2.19290082
99pre-miRNA processing (GO:0031054)2.19236393
100cellular sodium ion homeostasis (GO:0006883)2.18419278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00729629
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.91944993
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61780800
4WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.58803935
5TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.50255603
6ZFP281_18757296_ChIP-ChIP_E14_Mouse2.46856012
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28643838
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.26251000
9SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.14771668
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09489283
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04088183
12EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.00112970
13CLOCK_20551151_ChIP-Seq_293T_Human1.98211947
14DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.96822314
15WT1_19549856_ChIP-ChIP_CCG9911_Human1.91759956
16RARB_27405468_Chip-Seq_BRAIN_Mouse1.90095426
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89801181
18ZFP281_27345836_Chip-Seq_ESCs_Mouse1.86521675
19DROSHA_22980978_ChIP-Seq_HELA_Human1.82660076
20KDM2B_26808549_Chip-Seq_K562_Human1.80190343
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77743598
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74946472
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.72981418
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.72981418
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.72981418
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68959982
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68959982
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.68332104
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64510675
30EZH2_22144423_ChIP-Seq_EOC_Human1.61155909
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.58861375
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58173878
33YAP1_20516196_ChIP-Seq_MESCs_Mouse1.57746574
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.52735965
35ISL1_27105846_Chip-Seq_CPCs_Mouse1.52421724
36CTNNB1_20460455_ChIP-Seq_HCT116_Human1.51478872
37NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.51250303
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49219933
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47876232
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.44596357
41WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41738191
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.41699920
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41617052
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41280743
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40510884
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40093252
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36901380
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34830361
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.32411270
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29991137
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27283594
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26307552
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.25986684
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25852759
55GBX2_23144817_ChIP-Seq_PC3_Human1.25666396
56NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.24318029
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23919719
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21752927
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.21179721
60SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19544939
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19301575
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.17701025
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17178629
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17061975
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.16822166
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16331318
67TCF7_22412390_ChIP-Seq_EML_Mouse1.15533067
68REST_21632747_ChIP-Seq_MESCs_Mouse1.14487850
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14024205
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.13538751
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.13479651
72FOXA2_19822575_ChIP-Seq_HepG2_Human1.13383506
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12909173
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.11978559
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11812691
76POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09612732
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09038938
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.08545680
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07887201
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.03301999
81POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03090295
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02132748
83KDM2B_26808549_Chip-Seq_DND41_Human1.02115616
84TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02044134
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01351095
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00845277
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00251255
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99585046
89PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99134199
90EED_16625203_ChIP-ChIP_MESCs_Mouse0.98920719
91EZH2_27294783_Chip-Seq_ESCs_Mouse0.98590226
92SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98574756
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98545827
94NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98366263
95TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96992940
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.96825169
97NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96614412
98TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95734456
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94686751
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.92481492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.77439629
2MP0004270_analgesia3.81746490
3MP0003705_abnormal_hypodermis_morpholog3.11033883
4MP0003122_maternal_imprinting2.36748003
5MP0003635_abnormal_synaptic_transmissio2.34655439
6MP0005409_darkened_coat_color2.30791309
7MP0003880_abnormal_central_pattern2.16678836
8MP0000778_abnormal_nervous_system2.13736785
9MP0003329_amyloid_beta_deposits2.11866587
10MP0001177_atelectasis2.07312244
11MP0003690_abnormal_glial_cell2.06067078
12MP0005423_abnormal_somatic_nervous2.02256067
13MP0002734_abnormal_mechanical_nocicepti2.00327497
14MP0009780_abnormal_chondrocyte_physiolo1.98255763
15MP0003283_abnormal_digestive_organ1.79914370
16MP0002063_abnormal_learning/memory/cond1.78501553
17MP0000566_synostosis1.74816347
18MP0002822_catalepsy1.73423939
19MP0001486_abnormal_startle_reflex1.71884742
20MP0009672_abnormal_birth_weight1.69257332
21MP0005248_abnormal_Harderian_gland1.66613418
22MP0000462_abnormal_digestive_system1.66227504
23MP0005076_abnormal_cell_differentiation1.59991007
24MP0003890_abnormal_embryonic-extraembry1.56916830
25MP0003123_paternal_imprinting1.56386731
26MP0001299_abnormal_eye_distance/1.55674531
27MP0003634_abnormal_glial_cell1.54201860
28MP0000428_abnormal_craniofacial_morphol1.53446251
29MP0000537_abnormal_urethra_morphology1.51566533
30MP0008569_lethality_at_weaning1.49544586
31MP0002064_seizures1.48736053
32MP0000955_abnormal_spinal_cord1.48004203
33MP0004811_abnormal_neuron_physiology1.44543521
34MP0003115_abnormal_respiratory_system1.42162598
35MP0000920_abnormal_myelination1.41657922
36MP0003861_abnormal_nervous_system1.37830397
37MP0000534_abnormal_ureter_morphology1.35429523
38MP0008438_abnormal_cutaneous_collagen1.34606207
39MP0003119_abnormal_digestive_system1.34030374
40MP0004885_abnormal_endolymph1.32993842
41MP0004858_abnormal_nervous_system1.32889103
42MP0001849_ear_inflammation1.32819064
43MP0002152_abnormal_brain_morphology1.28174286
44MP0010030_abnormal_orbit_morphology1.26890448
45MP0001915_intracranial_hemorrhage1.26442405
46MP0002249_abnormal_larynx_morphology1.25961492
47MP0002735_abnormal_chemical_nociception1.25654386
48MP0009703_decreased_birth_body1.24327398
49MP0003566_abnormal_cell_adhesion1.17548893
50MP0001958_emphysema1.17228714
51MP0003632_abnormal_nervous_system1.15235239
52MP0010352_gastrointestinal_tract_polyps1.14790902
53MP0003385_abnormal_body_wall1.14569868
54MP0002089_abnormal_postnatal_growth/wei1.13802795
55MP0002572_abnormal_emotion/affect_behav1.11821555
56MP0005623_abnormal_meninges_morphology1.11032229
57MP0010234_abnormal_vibrissa_follicle1.10031138
58MP0003942_abnormal_urinary_system1.09028982
59MP0002233_abnormal_nose_morphology1.08961667
60MP0002882_abnormal_neuron_morphology1.07924807
61MP0003183_abnormal_peptide_metabolism1.05306988
62MP0002184_abnormal_innervation1.03506138
63MP0002084_abnormal_developmental_patter1.02530403
64MP0003121_genomic_imprinting1.02306065
65MP0002697_abnormal_eye_size1.02251136
66MP0004272_abnormal_basement_membrane1.01012442
67MP0003935_abnormal_craniofacial_develop1.00152894
68MP0002133_abnormal_respiratory_system0.98749544
69MP0005388_respiratory_system_phenotype0.98749544
70MP0001188_hyperpigmentation0.97954168
71MP0003938_abnormal_ear_development0.96415273
72MP0003787_abnormal_imprinting0.95743855
73MP0010368_abnormal_lymphatic_system0.95050426
74MP0009384_cardiac_valve_regurgitation0.93362961
75MP0002909_abnormal_adrenal_gland0.93287202
76MP0002272_abnormal_nervous_system0.92626614
77MP0002081_perinatal_lethality0.92574935
78MP0005257_abnormal_intraocular_pressure0.92453147
79MP0001730_embryonic_growth_arrest0.90956029
80MP0000579_abnormal_nail_morphology0.90851468
81MP0009745_abnormal_behavioral_response0.90705460
82MP0004264_abnormal_extraembryonic_tissu0.90280440
83MP0002896_abnormal_bone_mineralization0.89246720
84MP0002066_abnormal_motor_capabilities/c0.89115369
85MP0001984_abnormal_olfaction0.89087937
86MP0002085_abnormal_embryonic_tissue0.88639459
87MP0000432_abnormal_head_morphology0.88451705
88MP0003091_abnormal_cell_migration0.88115228
89MP0003631_nervous_system_phenotype0.87122706
90MP0002092_abnormal_eye_morphology0.86658557
91MP0003633_abnormal_nervous_system0.86557848
92MP0008260_abnormal_autophagy0.85254625
93MP0003941_abnormal_skin_development0.84937413
94MP0003937_abnormal_limbs/digits/tail_de0.81875177
95MP0002116_abnormal_craniofacial_bone0.80607026
96MP0002557_abnormal_social/conspecific_i0.78105326
97MP0001943_abnormal_respiration0.76772477
98MP0002009_preneoplasia0.74152024
99MP0002067_abnormal_sensory_capabilities0.72840107
100MP0004197_abnormal_fetal_growth/weight/0.72341054

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.14851093
2Insomnia (HP:0100785)2.94345317
3Arterial tortuosity (HP:0005116)2.78254275
4Ankle clonus (HP:0011448)2.74679264
5Obstructive sleep apnea (HP:0002870)2.73557860
6Neurofibrillary tangles (HP:0002185)2.72862367
7Vascular tortuosity (HP:0004948)2.72659498
8Overriding aorta (HP:0002623)2.64176058
9Arnold-Chiari malformation (HP:0002308)2.58487679
10Bowel diverticulosis (HP:0005222)2.56795338
11Turricephaly (HP:0000262)2.55109731
12Papillary thyroid carcinoma (HP:0002895)2.41604024
13Neonatal short-limb short stature (HP:0008921)2.41293326
14Renovascular hypertension (HP:0100817)2.41291470
15Action tremor (HP:0002345)2.39578944
16Protrusio acetabuli (HP:0003179)2.38144270
17Renal duplication (HP:0000075)2.34362042
18Increased nuchal translucency (HP:0010880)2.28494720
19Lower limb asymmetry (HP:0100559)2.27564559
20Elfin facies (HP:0004428)2.26298162
21Focal motor seizures (HP:0011153)2.24459048
22Cerebral inclusion bodies (HP:0100314)2.20539746
23Abnormality of the lower motor neuron (HP:0002366)2.17722950
24Aplasia involving bones of the extremities (HP:0009825)2.17340683
25Aplasia involving bones of the upper limbs (HP:0009823)2.17340683
26Aplasia of the phalanges of the hand (HP:0009802)2.17340683
27Spastic gait (HP:0002064)2.17289217
28Shallow orbits (HP:0000586)2.17126865
29Megalencephaly (HP:0001355)2.16994749
30Bladder diverticulum (HP:0000015)2.10631087
31Asymmetry of the thorax (HP:0001555)2.10623158
32Bronchomalacia (HP:0002780)2.10447206
33Vertebral arch anomaly (HP:0008438)2.06836264
34Termporal pattern (HP:0011008)2.06056473
35Insidious onset (HP:0003587)2.06056473
36Urinary urgency (HP:0000012)2.05944171
37Hepatoblastoma (HP:0002884)2.05689703
38Peripheral hypomyelination (HP:0007182)2.04388717
39Focal seizures (HP:0007359)2.03706927
40Vitreoretinal degeneration (HP:0000655)2.03139960
41Ankyloglossia (HP:0010296)2.01127951
42Abnormality of the corticospinal tract (HP:0002492)1.96691762
43Hand muscle atrophy (HP:0009130)1.95601214
44Hammertoe (HP:0001765)1.95074307
45Supranuclear gaze palsy (HP:0000605)1.95035429
46Impaired vibration sensation in the lower limbs (HP:0002166)1.93071091
47Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.92361853
48Obsessive-compulsive behavior (HP:0000722)1.92337293
49Cerebral aneurysm (HP:0004944)1.92175726
50Mild short stature (HP:0003502)1.90299869
51Myokymia (HP:0002411)1.90134190
52Malignant gastrointestinal tract tumors (HP:0006749)1.89408513
53Gastrointestinal carcinoma (HP:0002672)1.89408513
54Broad palm (HP:0001169)1.85427994
55Lower limb muscle weakness (HP:0007340)1.84748642
56Flat cornea (HP:0007720)1.84545571
57Heterotopia (HP:0002282)1.84429629
58Germ cell neoplasia (HP:0100728)1.84005591
59Leiomyosarcoma (HP:0100243)1.83460805
60Uterine leiomyosarcoma (HP:0002891)1.83460805
61Scanning speech (HP:0002168)1.82620027
62Upper limb amyotrophy (HP:0009129)1.80819322
63Distal upper limb amyotrophy (HP:0007149)1.80819322
64Transitional cell carcinoma of the bladder (HP:0006740)1.78703122
65Urinary bladder sphincter dysfunction (HP:0002839)1.76755993
66Broad metatarsal (HP:0001783)1.76227320
67Pointed chin (HP:0000307)1.76019665
68Cutaneous finger syndactyly (HP:0010554)1.74583663
69Metaphyseal cupping (HP:0003021)1.74302932
70Premature rupture of membranes (HP:0001788)1.72635831
71Thickened helices (HP:0000391)1.71826214
72Cutaneous syndactyly (HP:0012725)1.70170627
73Tetraplegia (HP:0002445)1.70137898
74Macroorchidism (HP:0000053)1.68818733
75Choanal stenosis (HP:0000452)1.68195627
76Back pain (HP:0003418)1.67376053
77Mitral valve prolapse (HP:0001634)1.67320914
78Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65955825
79Abnormality of the diencephalon (HP:0010662)1.65404625
80Alacrima (HP:0000522)1.65285789
81Overgrowth (HP:0001548)1.63883894
82Cortical dysplasia (HP:0002539)1.63811434
83Precocious puberty (HP:0000826)1.63454705
84Decreased motor nerve conduction velocity (HP:0003431)1.62360820
85Absent frontal sinuses (HP:0002688)1.61409310
86Coronal craniosynostosis (HP:0004440)1.60968397
87Hyperextensible skin (HP:0000974)1.59965335
88Split foot (HP:0001839)1.59504291
89Intention tremor (HP:0002080)1.58040798
90Omphalocele (HP:0001539)1.57467357
91Abnormality of dentin (HP:0010299)1.56459973
92Bladder neoplasm (HP:0009725)1.56198220
93Bladder carcinoma (HP:0002862)1.56198220
94Visceral angiomatosis (HP:0100761)1.55621095
95Torticollis (HP:0000473)1.55445111
96Hemangiomatosis (HP:0007461)1.54678417
97Deviation of the hallux (HP:0010051)1.54431260
98Neoplasm of the heart (HP:0100544)1.52249277
99Depression (HP:0000716)1.51971575
100Aqueductal stenosis (HP:0002410)1.51394771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.54171026
2EPHA42.67718987
3NTRK32.67241341
4LATS22.54228004
5RIPK12.51799557
6NTRK12.46026507
7PDGFRA2.41364827
8CASK2.40290830
9TRIB32.35916030
10TYRO32.20961518
11KSR22.13946345
12FGFR21.94663128
13NTRK21.90909776
14UHMK11.85129783
15MAP3K101.83148181
16KSR11.75337978
17FGFR41.60016172
18PAK61.57827050
19YES11.43031351
20PRKD31.42337835
21MAP3K91.41313912
22PKN21.39832553
23CDK121.36427029
24PRPF4B1.35348726
25RET1.34655861
26FGFR31.27116801
27MINK11.26138735
28SGK4941.24100669
29SGK2231.24100669
30NEK61.23275021
31ICK1.21651919
32PNCK1.19385895
33SGK21.17810499
34SGK31.17597041
35EEF2K1.14843022
36BRD41.14412313
37BCR1.14178572
38SMG11.13741872
39MAP3K21.09128642
40CAMK1G1.07916882
41DAPK21.07892326
42ALK1.07483838
43MARK21.06287217
44ROCK21.02554024
45CAMKK10.99871880
46CDK50.99025943
47WNK10.93782624
48LATS10.92216831
49PDGFRB0.90863580
50DYRK1A0.89002263
51CDK190.88944885
52SCYL20.87604706
53CDK180.85241361
54CDK150.84423441
55FGFR10.84195636
56MAPK100.81063325
57STK380.80739001
58DYRK1B0.79160329
59PTK20.79029113
60CDK11A0.78536989
61CDK140.72079675
62ERBB20.69791836
63MAP2K40.69666355
64PTK60.66167784
65CDK60.65785729
66MTOR0.65024373
67PRKCH0.62902198
68RAF10.62396878
69TNIK0.58586822
70RPS6KB10.57137430
71LMTK20.56826755
72MAP3K40.56489440
73BMX0.55440169
74MAP3K60.55171601
75MKNK10.53906883
76FYN0.53875988
77SGK10.52742194
78PAK20.51005009
79FES0.49395907
80PRKCZ0.48226999
81STK38L0.48008646
82AKT30.45129038
83DMPK0.45062293
84ROCK10.44678597
85MAP3K70.44652377
86TTK0.44209916
87RPS6KA20.43979776
88STK110.43614984
89SIK20.43522311
90FGR0.42781722
91BRAF0.42628544
92PLK20.41817232
93PDPK10.41608103
94SIK10.41403281
95JAK20.41250198
96CAMK2B0.40977422
97CSNK1G20.38917045
98EPHA30.38814799
99EPHB20.37996583
100EPHB10.37648339

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047201.99180272
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87458167
3Endometrial cancer_Homo sapiens_hsa052131.85764820
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73003340
5Adherens junction_Homo sapiens_hsa045201.56375696
6ErbB signaling pathway_Homo sapiens_hsa040121.54523954
7Glioma_Homo sapiens_hsa052141.54336428
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52521241
9Chronic myeloid leukemia_Homo sapiens_hsa052201.49142043
10Colorectal cancer_Homo sapiens_hsa052101.47178642
11Thyroid hormone signaling pathway_Homo sapiens_hsa049191.45966455
12Axon guidance_Homo sapiens_hsa043601.38011591
13Synaptic vesicle cycle_Homo sapiens_hsa047211.37760991
14Estrogen signaling pathway_Homo sapiens_hsa049151.35763958
15Nicotine addiction_Homo sapiens_hsa050331.35190419
16Glutamatergic synapse_Homo sapiens_hsa047241.31605962
17Renal cell carcinoma_Homo sapiens_hsa052111.31590459
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31074808
19Phospholipase D signaling pathway_Homo sapiens_hsa040721.30822547
20Choline metabolism in cancer_Homo sapiens_hsa052311.30307933
21Amphetamine addiction_Homo sapiens_hsa050311.27760983
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27552442
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.27128065
24Non-small cell lung cancer_Homo sapiens_hsa052231.26758076
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.22357710
26Circadian entrainment_Homo sapiens_hsa047131.22030489
27Thyroid cancer_Homo sapiens_hsa052161.22012978
28Gap junction_Homo sapiens_hsa045401.21324798
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20300227
30Dopaminergic synapse_Homo sapiens_hsa047281.19623621
31Wnt signaling pathway_Homo sapiens_hsa043101.19195506
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18463060
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17327260
34Melanogenesis_Homo sapiens_hsa049161.16129456
35Tight junction_Homo sapiens_hsa045301.14005508
36Cholinergic synapse_Homo sapiens_hsa047251.13744383
37Inositol phosphate metabolism_Homo sapiens_hsa005621.12546685
38Rap1 signaling pathway_Homo sapiens_hsa040151.09151292
39GABAergic synapse_Homo sapiens_hsa047271.08933968
40Cocaine addiction_Homo sapiens_hsa050301.08844380
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07769892
42Gastric acid secretion_Homo sapiens_hsa049711.07440261
43Hippo signaling pathway_Homo sapiens_hsa043901.05791303
44GnRH signaling pathway_Homo sapiens_hsa049121.03796237
45Notch signaling pathway_Homo sapiens_hsa043301.00414047
46mTOR signaling pathway_Homo sapiens_hsa041501.00122078
47Pancreatic cancer_Homo sapiens_hsa052120.99710433
48VEGF signaling pathway_Homo sapiens_hsa043700.99597175
49Focal adhesion_Homo sapiens_hsa045100.99357792
50Long-term depression_Homo sapiens_hsa047300.98748636
51Proteoglycans in cancer_Homo sapiens_hsa052050.98511689
52Insulin signaling pathway_Homo sapiens_hsa049100.96929380
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96116050
54Insulin secretion_Homo sapiens_hsa049110.95550002
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94530462
56Amoebiasis_Homo sapiens_hsa051460.94407465
57cAMP signaling pathway_Homo sapiens_hsa040240.94137150
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93986873
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92926233
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92485701
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.92331555
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91399593
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88878497
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87803622
65MicroRNAs in cancer_Homo sapiens_hsa052060.87350641
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86878341
67Prostate cancer_Homo sapiens_hsa052150.86674486
68Prolactin signaling pathway_Homo sapiens_hsa049170.86171265
69Dorso-ventral axis formation_Homo sapiens_hsa043200.85976645
70Thyroid hormone synthesis_Homo sapiens_hsa049180.84354849
71AMPK signaling pathway_Homo sapiens_hsa041520.83581142
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83165604
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.82159814
74Acute myeloid leukemia_Homo sapiens_hsa052210.81629530
75Prion diseases_Homo sapiens_hsa050200.81557244
76Endocytosis_Homo sapiens_hsa041440.80958340
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79823644
78Basal cell carcinoma_Homo sapiens_hsa052170.79044549
79Bile secretion_Homo sapiens_hsa049760.77130971
80Type II diabetes mellitus_Homo sapiens_hsa049300.76773295
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75808246
82Morphine addiction_Homo sapiens_hsa050320.75739725
83Hedgehog signaling pathway_Homo sapiens_hsa043400.75269684
84Oxytocin signaling pathway_Homo sapiens_hsa049210.75132379
85ECM-receptor interaction_Homo sapiens_hsa045120.74465615
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73855321
87Renin secretion_Homo sapiens_hsa049240.73386864
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72126429
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71791251
90Ras signaling pathway_Homo sapiens_hsa040140.70794058
91Oocyte meiosis_Homo sapiens_hsa041140.69559258
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67917979
93Protein digestion and absorption_Homo sapiens_hsa049740.65887036
94TGF-beta signaling pathway_Homo sapiens_hsa043500.62864656
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62187499
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61820107
97Glucagon signaling pathway_Homo sapiens_hsa049220.59852365
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58610205
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58161543
100mRNA surveillance pathway_Homo sapiens_hsa030150.57599717

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