GTF2H5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening during DNA repair, and is implicated in regulating cellular levels of TFIIH. Mutations in this gene result in trichothiodystrophy, complementation group A. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.52535960
2ATP synthesis coupled proton transport (GO:0015986)7.06627175
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.06627175
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.73219709
5respiratory electron transport chain (GO:0022904)5.80138729
6electron transport chain (GO:0022900)5.64336258
7protein neddylation (GO:0045116)5.62802306
8chaperone-mediated protein transport (GO:0072321)5.60854882
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.81982285
10behavioral response to nicotine (GO:0035095)4.75655975
11protein complex biogenesis (GO:0070271)4.43255071
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.29884011
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.29884011
14NADH dehydrogenase complex assembly (GO:0010257)4.29884011
15axon ensheathment in central nervous system (GO:0032291)4.21359009
16central nervous system myelination (GO:0022010)4.21359009
17GTP biosynthetic process (GO:0006183)4.19281654
18mitochondrial respiratory chain complex assembly (GO:0033108)3.93385364
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.84771389
20termination of RNA polymerase III transcription (GO:0006386)3.84771389
21long-chain fatty acid biosynthetic process (GO:0042759)3.83200849
22proteasome assembly (GO:0043248)3.78798490
23ribosomal small subunit biogenesis (GO:0042274)3.77491093
24water-soluble vitamin biosynthetic process (GO:0042364)3.75431537
25neuron cell-cell adhesion (GO:0007158)3.71829072
26hydrogen ion transmembrane transport (GO:1902600)3.69614742
27presynaptic membrane assembly (GO:0097105)3.68785182
28presynaptic membrane organization (GO:0097090)3.65596439
29cullin deneddylation (GO:0010388)3.55426387
30purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.48909195
31DNA deamination (GO:0045006)3.46296674
327-methylguanosine mRNA capping (GO:0006370)3.45618132
33RNA capping (GO:0036260)3.43192244
347-methylguanosine RNA capping (GO:0009452)3.43192244
35UTP biosynthetic process (GO:0006228)3.39815804
36purine nucleoside triphosphate biosynthetic process (GO:0009145)3.38966220
37regulation of mitochondrial translation (GO:0070129)3.38281928
38proton transport (GO:0015992)3.36467318
39gamma-aminobutyric acid transport (GO:0015812)3.32893411
40protein targeting to mitochondrion (GO:0006626)3.28979707
41ATP biosynthetic process (GO:0006754)3.28802778
42hydrogen transport (GO:0006818)3.28085730
43guanosine-containing compound biosynthetic process (GO:1901070)3.27044075
44regulation of cellular amino acid metabolic process (GO:0006521)3.25368727
45energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.25327400
46ATP hydrolysis coupled proton transport (GO:0015991)3.25327400
47protein deneddylation (GO:0000338)3.24347663
48establishment of protein localization to mitochondrion (GO:0072655)3.22807890
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21107670
50fatty acid elongation (GO:0030497)3.20148684
51inner mitochondrial membrane organization (GO:0007007)3.20119629
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.16630396
53substantia nigra development (GO:0021762)3.13854619
54fucose catabolic process (GO:0019317)3.13521429
55L-fucose metabolic process (GO:0042354)3.13521429
56L-fucose catabolic process (GO:0042355)3.13521429
57viral transcription (GO:0019083)3.09134369
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08607049
59response to pheromone (GO:0019236)3.06211580
60regulation of memory T cell differentiation (GO:0043380)3.06087596
61protein localization to mitochondrion (GO:0070585)3.05689051
62cotranslational protein targeting to membrane (GO:0006613)3.01989680
63translational termination (GO:0006415)3.01400296
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99157702
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99157702
66negative regulation of ligase activity (GO:0051352)2.98772024
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98772024
68ribonucleoside triphosphate biosynthetic process (GO:0009201)2.97434579
69translational elongation (GO:0006414)2.95853087
70pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95095883
71dopamine transport (GO:0015872)2.95000396
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94568381
73positive regulation of synapse assembly (GO:0051965)2.94389040
74respiratory chain complex IV assembly (GO:0008535)2.92896295
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92560484
76nucleoside diphosphate phosphorylation (GO:0006165)2.91782437
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91600637
78protein targeting to ER (GO:0045047)2.91351832
79preassembly of GPI anchor in ER membrane (GO:0016254)2.90336901
80platelet dense granule organization (GO:0060155)2.88293453
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88257364
82protein-cofactor linkage (GO:0018065)2.86624599
83epithelial cilium movement (GO:0003351)2.85541548
84transmission of nerve impulse (GO:0019226)2.85011965
85neuronal action potential propagation (GO:0019227)2.84788084
86protein localization to endoplasmic reticulum (GO:0070972)2.83202266
87sulfation (GO:0051923)2.82539141
88cytochrome complex assembly (GO:0017004)2.81759297
89mannosylation (GO:0097502)2.79131820
90establishment of integrated proviral latency (GO:0075713)2.78623461
91establishment of protein localization to endoplasmic reticulum (GO:0072599)2.78342868
92regulation of cilium movement (GO:0003352)2.78285858
93deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.77912672
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77371323
95DNA double-strand break processing (GO:0000729)2.76284816
96C4-dicarboxylate transport (GO:0015740)2.75261229
97UTP metabolic process (GO:0046051)2.75165939
98neuron recognition (GO:0008038)2.73982840
99negative regulation of response to food (GO:0032096)2.73469499
100negative regulation of appetite (GO:0032099)2.73469499
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.73006940
102CTP biosynthetic process (GO:0006241)2.72748173
103CTP metabolic process (GO:0046036)2.72748173
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.71321908
105regulation of cellular amine metabolic process (GO:0033238)2.70668377
106signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68180126
107intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68180126
108regulation of catecholamine metabolic process (GO:0042069)2.67751661
109regulation of dopamine metabolic process (GO:0042053)2.67751661
110GPI anchor metabolic process (GO:0006505)2.67627379
111establishment of viral latency (GO:0019043)2.67175243
112transferrin transport (GO:0033572)2.66719400
113ribosomal small subunit assembly (GO:0000028)2.66493913
114nucleoside triphosphate biosynthetic process (GO:0009142)2.66325123
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.66105345
116signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.66105345
117signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66105345
118dopamine biosynthetic process (GO:0042416)2.66058521
119protein localization to synapse (GO:0035418)2.65864861
120viral life cycle (GO:0019058)2.65219151
121protein localization to cilium (GO:0061512)2.65190411
122regulation of glutamate secretion (GO:0014048)2.65085515
123detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64621118
124translation (GO:0006412)2.63988425
125cellular protein complex disassembly (GO:0043624)2.62401481
126ribosomal large subunit biogenesis (GO:0042273)2.62028099
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61918301
128axoneme assembly (GO:0035082)2.61741218
129somite development (GO:0061053)2.61292085
130positive regulation of protein homodimerization activity (GO:0090073)2.61228126
131anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61225305
132positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.60859034
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60015072
134intracellular protein transmembrane import (GO:0044743)2.59424516
135nonmotile primary cilium assembly (GO:0035058)2.58187991
136signal transduction involved in cell cycle checkpoint (GO:0072395)2.57892899
137positive regulation of cell fate commitment (GO:0010455)2.53281661
138anterograde axon cargo transport (GO:0008089)2.49864730
139cellular ketone body metabolic process (GO:0046950)2.47666560
140indolalkylamine metabolic process (GO:0006586)2.46304400
141replication fork processing (GO:0031297)2.46264091
142otic vesicle formation (GO:0030916)2.45734900
143maturation of SSU-rRNA (GO:0030490)2.45676930
144cilium movement (GO:0003341)2.45272607
145anterograde synaptic vesicle transport (GO:0048490)2.45180177
146regulation of action potential (GO:0098900)2.43717534
147negative regulation of transcription regulatory region DNA binding (GO:2000678)2.42670644
148detection of light stimulus involved in visual perception (GO:0050908)2.41389374
149detection of light stimulus involved in sensory perception (GO:0050962)2.41389374
150positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.38374439
151cell proliferation in forebrain (GO:0021846)2.37554433
152kynurenine metabolic process (GO:0070189)2.36800694
153indole-containing compound catabolic process (GO:0042436)2.36786342
154indolalkylamine catabolic process (GO:0046218)2.36786342
155tryptophan catabolic process (GO:0006569)2.36786342
156male meiosis I (GO:0007141)2.34866636
157pyrimidine nucleotide catabolic process (GO:0006244)2.34791751
158pyrimidine nucleobase catabolic process (GO:0006208)2.33981499
159synaptic transmission, cholinergic (GO:0007271)2.33936171
160base-excision repair, AP site formation (GO:0006285)2.33355028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02678635
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.98384104
3EZH2_22144423_ChIP-Seq_EOC_Human3.82550978
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57426277
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.35619281
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.16355637
7GBX2_23144817_ChIP-Seq_PC3_Human2.83239674
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.79278229
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72248121
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50295685
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49400112
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47186894
13TAF15_26573619_Chip-Seq_HEK293_Human2.42783335
14VDR_22108803_ChIP-Seq_LS180_Human2.37360699
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.33159559
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29368860
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29219450
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29136012
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18040023
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12693851
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12106323
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04908002
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.96900594
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94584076
25FUS_26573619_Chip-Seq_HEK293_Human1.92635026
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84836721
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83500938
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83087371
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81482127
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.79355231
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78491724
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76138296
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.74471839
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71239906
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69071292
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63407803
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62632494
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61630681
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59269348
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57918533
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55677829
42ER_23166858_ChIP-Seq_MCF-7_Human1.55421615
43P300_19829295_ChIP-Seq_ESCs_Human1.54777024
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53923869
45ELK1_19687146_ChIP-ChIP_HELA_Human1.50721961
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45720945
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45567517
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43510380
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.42191452
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39252649
51SOX2_19829295_ChIP-Seq_ESCs_Human1.38575921
52NANOG_19829295_ChIP-Seq_ESCs_Human1.38575921
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36587070
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36587070
55TP53_22573176_ChIP-Seq_HFKS_Human1.35374607
56RNF2_27304074_Chip-Seq_NSC_Mouse1.35077283
57BCAT_22108803_ChIP-Seq_LS180_Human1.34388566
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.33996416
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.33500064
60REST_21632747_ChIP-Seq_MESCs_Mouse1.33358820
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32050218
62CBP_20019798_ChIP-Seq_JUKART_Human1.30954025
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30954025
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30847355
65IRF1_19129219_ChIP-ChIP_H3396_Human1.29128736
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27703746
67VDR_23849224_ChIP-Seq_CD4+_Human1.27185421
68DCP1A_22483619_ChIP-Seq_HELA_Human1.26917967
69CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.26564833
70AR_25329375_ChIP-Seq_VCAP_Human1.26266433
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25576426
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24898517
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.24898517
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24717136
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23314600
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.22347315
77IGF1R_20145208_ChIP-Seq_DFB_Human1.21749140
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20637522
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19363390
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19069494
81* EWS_26573619_Chip-Seq_HEK293_Human1.18145075
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.17132931
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17051819
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15756950
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15449771
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15009829
87JUN_21703547_ChIP-Seq_K562_Human1.14052863
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13024731
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11114228
90* MYC_18555785_ChIP-Seq_MESCs_Mouse1.10890257
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.10792395
92TCF4_23295773_ChIP-Seq_U87_Human1.10457743
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10125861
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08786984
95TCF4_22108803_ChIP-Seq_LS180_Human1.08571394
96* STAT3_23295773_ChIP-Seq_U87_Human1.08001464
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.07879848
98NCOR_22424771_ChIP-Seq_293T_Human1.07724498
99HTT_18923047_ChIP-ChIP_STHdh_Human1.07549561
100TTF2_22483619_ChIP-Seq_HELA_Human1.06034866
101* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05283223
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05054508
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05046797
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03049940
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02752474
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02452508
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.02409232
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02330692
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02146786
110AR_20517297_ChIP-Seq_VCAP_Human1.01201473
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00821212
112REST_18959480_ChIP-ChIP_MESCs_Mouse1.00337606
113AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99914344
114* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99712868
115GATA3_21878914_ChIP-Seq_MCF-7_Human0.99319052
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98876660
117ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98648839
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97479888
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.97476119
120FLI1_21867929_ChIP-Seq_TH2_Mouse0.97240896
121RNF2_27304074_Chip-Seq_ESCs_Mouse0.97145570
122RUNX2_22187159_ChIP-Seq_PCA_Human0.96765836
123CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96241138
124MYC_18940864_ChIP-ChIP_HL60_Human0.95919713
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95806562
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95806562
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95467918
128ZNF274_21170338_ChIP-Seq_K562_Hela0.93247575
129SMAD4_21799915_ChIP-Seq_A2780_Human0.90687498
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89584108
131AR_21572438_ChIP-Seq_LNCaP_Human0.87637701
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86872517
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86620669
134TAL1_26923725_Chip-Seq_HPCs_Mouse0.86578099
135P53_22387025_ChIP-Seq_ESCs_Mouse0.86473397
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86277492
137* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85975897
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.85352591
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85221010
140CMYC_18555785_Chip-Seq_ESCs_Mouse0.84929065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.14283129
2MP0001529_abnormal_vocalization3.54339106
3MP0009379_abnormal_foot_pigmentation3.31438158
4MP0006276_abnormal_autonomic_nervous2.88794059
5MP0001905_abnormal_dopamine_level2.88767502
6MP0001968_abnormal_touch/_nociception2.53197963
7MP0004859_abnormal_synaptic_plasticity2.46602734
8MP0003136_yellow_coat_color2.44568695
9MP0002736_abnormal_nociception_after2.42702455
10MP0009745_abnormal_behavioral_response2.37728641
11MP0004270_analgesia2.37397581
12MP0003635_abnormal_synaptic_transmissio2.33681794
13MP0002064_seizures2.30108785
14MP0002272_abnormal_nervous_system2.28686654
15MP0002734_abnormal_mechanical_nocicepti2.18503338
16MP0009046_muscle_twitch2.16021469
17MP0004142_abnormal_muscle_tone2.14162353
18MP0002735_abnormal_chemical_nociception2.13460724
19MP0001440_abnormal_grooming_behavior2.11434592
20MP0002572_abnormal_emotion/affect_behav2.09984608
21MP0000778_abnormal_nervous_system2.09860097
22MP0001188_hyperpigmentation2.08526984
23MP0003646_muscle_fatigue2.05705728
24MP0002063_abnormal_learning/memory/cond2.04200008
25MP0005423_abnormal_somatic_nervous2.03427528
26MP0001486_abnormal_startle_reflex1.97814612
27MP0008875_abnormal_xenobiotic_pharmacok1.91351108
28MP0003011_delayed_dark_adaptation1.88327762
29MP0008877_abnormal_DNA_methylation1.88253235
30MP0005409_darkened_coat_color1.87591679
31MP0004885_abnormal_endolymph1.87427162
32MP0003195_calcinosis1.81533554
33MP0002160_abnormal_reproductive_system1.80204493
34MP0002163_abnormal_gland_morphology1.78739183
35MP0008872_abnormal_physiological_respon1.78576467
36MP0002638_abnormal_pupillary_reflex1.78233872
37MP0001970_abnormal_pain_threshold1.73722905
38MP0005171_absent_coat_pigmentation1.70963669
39MP0004742_abnormal_vestibular_system1.68042787
40MP0002067_abnormal_sensory_capabilities1.66028564
41MP0000920_abnormal_myelination1.64528212
42MP0002184_abnormal_innervation1.59982218
43MP0002102_abnormal_ear_morphology1.59923574
44MP0001501_abnormal_sleep_pattern1.58811641
45MP0002733_abnormal_thermal_nociception1.57309377
46MP0005084_abnormal_gallbladder_morpholo1.50714715
47MP0004924_abnormal_behavior1.48268744
48MP0005386_behavior/neurological_phenoty1.48268744
49MP0005389_reproductive_system_phenotype1.44283701
50MP0002876_abnormal_thyroid_physiology1.44045120
51MP0003787_abnormal_imprinting1.42731542
52MP0000569_abnormal_digit_pigmentation1.40630309
53MP0010386_abnormal_urinary_bladder1.39972399
54MP0004133_heterotaxia1.37422531
55MP0002234_abnormal_pharynx_morphology1.36012882
56MP0006292_abnormal_olfactory_placode1.34511201
57MP0001984_abnormal_olfaction1.33008139
58MP0005645_abnormal_hypothalamus_physiol1.32906913
59MP0002837_dystrophic_cardiac_calcinosis1.32874691
60MP0001485_abnormal_pinna_reflex1.31151562
61MP0005379_endocrine/exocrine_gland_phen1.30181537
62MP0000372_irregular_coat_pigmentation1.28440335
63MP0003938_abnormal_ear_development1.26668046
64MP0002653_abnormal_ependyma_morphology1.26521087
65MP0001986_abnormal_taste_sensitivity1.22263607
66MP0002557_abnormal_social/conspecific_i1.22211238
67MP0003718_maternal_effect1.21614826
68MP0003186_abnormal_redox_activity1.19403096
69MP0003122_maternal_imprinting1.19333006
70MP0000026_abnormal_inner_ear1.18521499
71MP0002882_abnormal_neuron_morphology1.16691895
72MP0001963_abnormal_hearing_physiology1.15867203
73MP0002066_abnormal_motor_capabilities/c1.15343932
74MP0006035_abnormal_mitochondrial_morpho1.13223423
75MP0003329_amyloid_beta_deposits1.12302617
76MP0006072_abnormal_retinal_apoptosis1.11124105
77MP0005551_abnormal_eye_electrophysiolog1.10955429
78MP0002752_abnormal_somatic_nervous1.09993959
79MP0008789_abnormal_olfactory_epithelium1.08622220
80MP0000566_synostosis1.05359296
81MP0001727_abnormal_embryo_implantation1.03736353
82MP0008260_abnormal_autophagy1.02211662
83MP0004145_abnormal_muscle_electrophysio1.01548805
84MP0002229_neurodegeneration1.01252748
85MP0002938_white_spotting1.00745342
86MP0003121_genomic_imprinting1.00682794
87MP0005174_abnormal_tail_pigmentation1.00631755
88MP0004215_abnormal_myocardial_fiber1.00143235
89MP0000955_abnormal_spinal_cord0.98933012
90MP0000631_abnormal_neuroendocrine_gland0.97418880
91MP0005646_abnormal_pituitary_gland0.96869809
92MP0001293_anophthalmia0.96081479
93MP0008058_abnormal_DNA_repair0.95820106
94MP0006036_abnormal_mitochondrial_physio0.95348976
95MP0003634_abnormal_glial_cell0.93307988
96MP0005332_abnormal_amino_acid0.92415537
97MP0002751_abnormal_autonomic_nervous0.91559211
98MP0004381_abnormal_hair_follicle0.90038549
99MP0003937_abnormal_limbs/digits/tail_de0.88971460
100MP0005499_abnormal_olfactory_system0.86806560
101MP0005394_taste/olfaction_phenotype0.86806560
102MP0001919_abnormal_reproductive_system0.85766084
103MP0003283_abnormal_digestive_organ0.82975594
104MP0008995_early_reproductive_senescence0.82908515
105MP0003315_abnormal_perineum_morphology0.82433193
106MP0003119_abnormal_digestive_system0.81407190
107MP0005085_abnormal_gallbladder_physiolo0.81135470
108MP0004043_abnormal_pH_regulation0.80084600
109MP0001502_abnormal_circadian_rhythm0.79938513
110MP0002822_catalepsy0.79849483
111MP0001764_abnormal_homeostasis0.79513995
112MP0002095_abnormal_skin_pigmentation0.79230324
113MP0004811_abnormal_neuron_physiology0.78328607
114MP0002282_abnormal_trachea_morphology0.77838318
115MP0002152_abnormal_brain_morphology0.77755207
116MP0002277_abnormal_respiratory_mucosa0.77083098
117MP0000427_abnormal_hair_cycle0.76501120
118MP0003806_abnormal_nucleotide_metabolis0.76325106
119MP0003252_abnormal_bile_duct0.75528881
120MP0005253_abnormal_eye_physiology0.73746943
121MP0008932_abnormal_embryonic_tissue0.73300844
122MP0004147_increased_porphyrin_level0.71926459
123MP0001542_abnormal_bone_strength0.70405546
124MP0009250_abnormal_appendicular_skeleto0.69001548
125MP0003879_abnormal_hair_cell0.68673942
126MP0000015_abnormal_ear_pigmentation0.67440003
127MP0003950_abnormal_plasma_membrane0.67272137
128MP0005195_abnormal_posterior_eye0.65191308
129MP0003690_abnormal_glial_cell0.63569142
130MP0008569_lethality_at_weaning0.62606916
131MP0000049_abnormal_middle_ear0.62580756
132MP0005410_abnormal_fertilization0.58564616
133MP0002295_abnormal_pulmonary_circulatio0.58011127
134MP0001664_abnormal_digestion0.56607341
135MP0000538_abnormal_urinary_bladder0.55928232

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.45441999
2Abnormal mitochondria in muscle tissue (HP:0008316)5.63770454
3Mitochondrial inheritance (HP:0001427)5.62056157
4Progressive macrocephaly (HP:0004481)5.48288200
5Acute encephalopathy (HP:0006846)5.02615858
6Hepatocellular necrosis (HP:0001404)4.64041986
7Increased CSF lactate (HP:0002490)4.63875652
8Increased hepatocellular lipid droplets (HP:0006565)4.51319122
9Renal Fanconi syndrome (HP:0001994)4.19787333
10Abnormality of glycolysis (HP:0004366)4.16390335
11Increased serum pyruvate (HP:0003542)4.16390335
123-Methylglutaconic aciduria (HP:0003535)3.98522171
13Molar tooth sign on MRI (HP:0002419)3.93032611
14Abnormality of midbrain morphology (HP:0002418)3.93032611
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.84263167
16Lipid accumulation in hepatocytes (HP:0006561)3.81737246
17Parakeratosis (HP:0001036)3.73360030
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.66556165
19True hermaphroditism (HP:0010459)3.61759281
20Hepatic necrosis (HP:0002605)3.61158391
21Leukodystrophy (HP:0002415)3.53638186
22Optic disc pallor (HP:0000543)3.48617228
23Nephronophthisis (HP:0000090)3.29912324
24Focal motor seizures (HP:0011153)3.25293817
25Respiratory failure (HP:0002878)3.24919003
26Exercise intolerance (HP:0003546)3.13295158
27Cerebral edema (HP:0002181)3.10207764
28Congenital, generalized hypertrichosis (HP:0004540)2.92805028
29Myokymia (HP:0002411)2.90541219
30Increased intramyocellular lipid droplets (HP:0012240)2.90160022
31Congenital stationary night blindness (HP:0007642)2.89839396
32Increased serum lactate (HP:0002151)2.86567878
33Exertional dyspnea (HP:0002875)2.85143180
34Lactic acidosis (HP:0003128)2.79767971
35Abnormality of renal resorption (HP:0011038)2.77036971
36Methylmalonic acidemia (HP:0002912)2.73380608
37Abnormality of alanine metabolism (HP:0010916)2.73143855
38Hyperalaninemia (HP:0003348)2.73143855
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73143855
40Type II lissencephaly (HP:0007260)2.70978815
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69238555
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69238555
43Abnormality of the renal medulla (HP:0100957)2.67563994
44Medial flaring of the eyebrow (HP:0010747)2.64141020
45Respiratory difficulties (HP:0002880)2.59899207
46X-linked dominant inheritance (HP:0001423)2.52386268
47Abnormality of cells of the erythroid lineage (HP:0012130)2.51968520
48* Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.49446864
49Gait imbalance (HP:0002141)2.49419977
50Cerebral hypomyelination (HP:0006808)2.47939906
51Sensory axonal neuropathy (HP:0003390)2.47568888
52Abnormality of the renal cortex (HP:0011035)2.43663633
53Pendular nystagmus (HP:0012043)2.41378229
54Sclerocornea (HP:0000647)2.40232825
55Methylmalonic aciduria (HP:0012120)2.38189312
56Abnormal hair whorl (HP:0010721)2.36333465
57Cystic liver disease (HP:0006706)2.33142318
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32270768
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.32270768
60Congenital primary aphakia (HP:0007707)2.30454750
61Limb dystonia (HP:0002451)2.29985362
62Abnormal number of erythroid precursors (HP:0012131)2.29820043
63Atonic seizures (HP:0010819)2.29262643
64Epileptic encephalopathy (HP:0200134)2.28223455
65Neuroendocrine neoplasm (HP:0100634)2.27385017
66Delusions (HP:0000746)2.26592043
67Progressive cerebellar ataxia (HP:0002073)2.22668918
68Retinal dysplasia (HP:0007973)2.22414309
69Increased muscle lipid content (HP:0009058)2.19493858
70Macrocytic anemia (HP:0001972)2.18205254
71Abnormal rod and cone electroretinograms (HP:0008323)2.16623839
72Nephrogenic diabetes insipidus (HP:0009806)2.16542372
73Hyperventilation (HP:0002883)2.16441573
74Vaginal atresia (HP:0000148)2.13875180
75Abolished electroretinogram (ERG) (HP:0000550)2.13680036
76Renal cortical cysts (HP:0000803)2.12515691
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.11597109
78Pheochromocytoma (HP:0002666)2.11539881
79Male pseudohermaphroditism (HP:0000037)2.11098721
80Genital tract atresia (HP:0001827)2.10558846
81Neurofibrillary tangles (HP:0002185)2.09730211
82Gaze-evoked nystagmus (HP:0000640)2.09062616
83Emotional lability (HP:0000712)2.09028632
84Broad-based gait (HP:0002136)2.08974658
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.07136365
86Hypothermia (HP:0002045)2.06029842
87Chronic hepatic failure (HP:0100626)2.01646743
88Increased corneal curvature (HP:0100692)2.00633309
89Keratoconus (HP:0000563)2.00633309
90Abnormal ciliary motility (HP:0012262)2.00098459
91Furrowed tongue (HP:0000221)1.99834795
92CNS demyelination (HP:0007305)1.98642080
93Progressive external ophthalmoplegia (HP:0000590)1.98582730
94Anencephaly (HP:0002323)1.97530020
95Optic nerve hypoplasia (HP:0000609)1.96404263
96Glycosuria (HP:0003076)1.95075906
97Abnormality of urine glucose concentration (HP:0011016)1.95075906
98Amniotic constriction ring (HP:0009775)1.94728054
99Abnormality of placental membranes (HP:0011409)1.94728054
100Esotropia (HP:0000565)1.93861471
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93398978
102Polyphagia (HP:0002591)1.92082455
103Abnormal pupillary function (HP:0007686)1.91571689
104Short tibia (HP:0005736)1.90622688
105Decreased central vision (HP:0007663)1.89137025
106Dialeptic seizures (HP:0011146)1.89063367
107Absence seizures (HP:0002121)1.87399529
108Postaxial foot polydactyly (HP:0001830)1.87287930
109Hyperglycinemia (HP:0002154)1.87162498
110Adrenal hypoplasia (HP:0000835)1.87033624
111Stenosis of the external auditory canal (HP:0000402)1.86327041
112Congenital sensorineural hearing impairment (HP:0008527)1.86282992
113Hyperphosphaturia (HP:0003109)1.86110112
114Aplasia/hypoplasia of the uterus (HP:0008684)1.86041268
115Large for gestational age (HP:0001520)1.83796190
116Genetic anticipation (HP:0003743)1.82502679
117Tubular atrophy (HP:0000092)1.82453730
118Intestinal atresia (HP:0011100)1.82450793
119Congenital hepatic fibrosis (HP:0002612)1.81705950
120Lethargy (HP:0001254)1.81642054
121Attenuation of retinal blood vessels (HP:0007843)1.81493150
122Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81323207
123Abnormality of the axillary hair (HP:0100134)1.80729852
124Abnormality of secondary sexual hair (HP:0009888)1.80729852
125Abnormal respiratory epithelium morphology (HP:0012253)1.78452568
126Abnormal respiratory motile cilium morphology (HP:0005938)1.78452568
127Absent thumb (HP:0009777)1.78341921
128Abnormal drinking behavior (HP:0030082)1.76936131
129Polydipsia (HP:0001959)1.76936131
130Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76364658
131Poor suck (HP:0002033)1.74881968
132Focal seizures (HP:0007359)1.74715242
133Hemiparesis (HP:0001269)1.71624272
134CNS hypomyelination (HP:0003429)1.69681015
135Split foot (HP:0001839)1.68809831
136Conical tooth (HP:0000698)1.67675616
137Pancreatic fibrosis (HP:0100732)1.67209882
138Progressive inability to walk (HP:0002505)1.65915939
139Reticulocytopenia (HP:0001896)1.65108836
140Absent/shortened dynein arms (HP:0200106)1.65077345
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.65077345
142Abnormality of the septum pellucidum (HP:0007375)1.62230573
143Cerebral inclusion bodies (HP:0100314)1.60970651
144Abnormality of the corticospinal tract (HP:0002492)1.60867806
145Abnormal urine phosphate concentration (HP:0012599)1.58919335
146Pancreatic cysts (HP:0001737)1.57815340
147Nasolacrimal duct obstruction (HP:0000579)1.57092819
148* Congenital ichthyosiform erythroderma (HP:0007431)1.54545551
149Abnormal respiratory motile cilium physiology (HP:0012261)1.53873423
150Renal tubular dysfunction (HP:0000124)1.53694919
151Anxiety (HP:0000739)1.53564640
152Concave nail (HP:0001598)1.53362755
153Aplasia/Hypoplasia of the lens (HP:0008063)1.52995334
154Amblyopia (HP:0000646)1.52336670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.18827134
2CASK3.54730949
3NME13.05536082
4MAP3K122.59212516
5MAP4K22.55438093
6GRK12.45923543
7STK392.45397177
8PNCK2.44831962
9STK162.42110161
10ARAF2.34567661
11PBK2.28366453
12MARK12.24677342
13BUB12.23433981
14ZAK2.19054758
15BCR2.13991118
16OXSR12.05293421
17NUAK12.02009906
18PINK11.98244578
19VRK21.89245867
20CDK191.85298752
21EPHA41.81784441
22PLK21.79679952
23MST41.78567383
24LIMK11.74494401
25NME21.68767816
26MAP2K71.68419138
27NTRK31.61796029
28BMPR21.59863375
29BMPR1B1.58449234
30TNIK1.56859570
31DYRK21.52793640
32PHKG21.48392395
33PHKG11.48392395
34EIF2AK11.47740058
35VRK11.46391521
36TLK11.46321837
37INSRR1.45872114
38SRPK11.44018285
39RIPK41.40618455
40GRK51.39267439
41MAPK131.38114546
42GRK71.32424594
43BRAF1.29585351
44CAMK2B1.28581028
45TIE11.28493384
46BCKDK1.25291975
47NEK11.19215180
48TAOK31.16268093
49ACVR1B1.14516662
50CSNK1G31.13866741
51ADRBK21.10857844
52MINK11.10455501
53PAK31.09759232
54UHMK11.04177999
55PKN11.03940387
56TRIM281.02255013
57FGR1.02173972
58MUSK1.00425955
59WNK40.99346380
60CAMK2A0.98593732
61MAP3K40.96835760
62MAPKAPK50.96767326
63PIM20.96186601
64MYLK0.91494970
65EIF2AK30.90902395
66DAPK20.90233973
67MKNK20.88267023
68NTRK20.88075564
69TESK20.87449272
70MKNK10.86838061
71MAPKAPK30.85182055
72PLK40.84685071
73ABL20.84146887
74CAMK2D0.83577901
75CDK140.82257074
76IRAK20.82164368
77PRPF4B0.81725047
78PRKCE0.80579175
79TXK0.80544133
80CSNK1G20.80485174
81TSSK60.78479424
82WEE10.77619918
83NEK60.75067601
84PRKCG0.74896513
85CAMK2G0.73394510
86ROCK20.72460588
87CAMKK20.72281005
88CCNB10.72005353
89CDK180.71376725
90PLK30.71304887
91CSNK1G10.69863357
92CDK150.67260163
93CDK50.66505839
94ERBB30.66325828
95ADRBK10.66139347
96BRSK20.64025229
97DYRK1A0.63916223
98CDK11A0.62705374
99MAP3K90.61582985
100DAPK30.61197259
101NEK20.60813550
102TGFBR10.60721392
103CSNK1A1L0.59927908
104EPHB20.59316918
105AURKA0.57270321
106STK110.56467647
107MAPK150.54410333
108PRKCI0.54359550
109STK38L0.53550864
110NTRK10.53414750
111YES10.52763650
112PLK10.52204236
113CDK30.51404132
114STK30.51241094
115TEC0.49658492
116PIK3CA0.49253482
117TAF10.48724197
118CDK80.48554309
119PRKCA0.48086262
120PDK20.47032421
121PTK2B0.45814175
122OBSCN0.45449508
123PRKG10.45279968
124WNK30.43966219
125EIF2AK20.43541437
126AKT30.43072929
127PRKACA0.43009270
128ILK0.42542856
129PRKACB0.40653911
130RPS6KA50.39407880
131IRAK40.38402532
132MAP2K60.38355551
133MAP2K40.38066414
134CAMK10.37338302
135CSNK2A10.36801049
136SIK30.34546339
137FES0.34336009
138CSNK2A20.32700222
139DAPK10.32022794
140CSNK1A10.30726170
141PAK10.30464671

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.67055259
2Parkinsons disease_Homo sapiens_hsa050124.62226778
3Proteasome_Homo sapiens_hsa030503.90072052
4Alzheimers disease_Homo sapiens_hsa050103.67010836
5Ribosome_Homo sapiens_hsa030103.55890874
6Huntingtons disease_Homo sapiens_hsa050163.42651897
7RNA polymerase_Homo sapiens_hsa030203.08974288
8Protein export_Homo sapiens_hsa030602.84802679
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.71063292
10Collecting duct acid secretion_Homo sapiens_hsa049662.54197411
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.47676463
12Nicotine addiction_Homo sapiens_hsa050332.19624398
13Cardiac muscle contraction_Homo sapiens_hsa042602.15950779
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78843810
15Vibrio cholerae infection_Homo sapiens_hsa051101.73074096
16Synaptic vesicle cycle_Homo sapiens_hsa047211.63618566
17Nitrogen metabolism_Homo sapiens_hsa009101.56341838
18Fatty acid elongation_Homo sapiens_hsa000621.56185086
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.45797970
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41286162
21Steroid biosynthesis_Homo sapiens_hsa001001.40403188
22Serotonergic synapse_Homo sapiens_hsa047261.37676106
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36628626
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32788865
25Chemical carcinogenesis_Homo sapiens_hsa052041.32665706
26Pyrimidine metabolism_Homo sapiens_hsa002401.30894543
27Tryptophan metabolism_Homo sapiens_hsa003801.30465546
28Rheumatoid arthritis_Homo sapiens_hsa053231.28777403
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25709135
30Phototransduction_Homo sapiens_hsa047441.24521100
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23946433
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23565852
33Propanoate metabolism_Homo sapiens_hsa006401.23126334
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22537509
35GABAergic synapse_Homo sapiens_hsa047271.16146931
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15249324
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.13794423
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08875744
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.06061261
40Ether lipid metabolism_Homo sapiens_hsa005651.03883478
41Spliceosome_Homo sapiens_hsa030401.03882052
42Glutamatergic synapse_Homo sapiens_hsa047241.03796449
43Peroxisome_Homo sapiens_hsa041461.03267718
44Morphine addiction_Homo sapiens_hsa050321.02811398
45Retinol metabolism_Homo sapiens_hsa008301.02778417
46Taste transduction_Homo sapiens_hsa047420.95509914
47Long-term depression_Homo sapiens_hsa047300.93219464
48Circadian entrainment_Homo sapiens_hsa047130.92474370
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91884093
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91785477
51Purine metabolism_Homo sapiens_hsa002300.91664583
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91483200
53Caffeine metabolism_Homo sapiens_hsa002320.91381605
54Amphetamine addiction_Homo sapiens_hsa050310.89760702
55Selenocompound metabolism_Homo sapiens_hsa004500.89547764
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87734835
57One carbon pool by folate_Homo sapiens_hsa006700.85926813
58Sulfur metabolism_Homo sapiens_hsa009200.83201768
59Dopaminergic synapse_Homo sapiens_hsa047280.82343747
60Phagosome_Homo sapiens_hsa041450.81911324
61Long-term potentiation_Homo sapiens_hsa047200.81903018
62Folate biosynthesis_Homo sapiens_hsa007900.81858569
63beta-Alanine metabolism_Homo sapiens_hsa004100.81038374
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80950108
65* Basal transcription factors_Homo sapiens_hsa030220.80127817
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79691126
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79495402
68Vitamin B6 metabolism_Homo sapiens_hsa007500.77650592
69Axon guidance_Homo sapiens_hsa043600.74844799
70Sphingolipid metabolism_Homo sapiens_hsa006000.72475332
71Regulation of autophagy_Homo sapiens_hsa041400.71511821
72Homologous recombination_Homo sapiens_hsa034400.69198168
73Graft-versus-host disease_Homo sapiens_hsa053320.68731570
74Sulfur relay system_Homo sapiens_hsa041220.65802135
75Fatty acid degradation_Homo sapiens_hsa000710.64519300
76Metabolic pathways_Homo sapiens_hsa011000.64078266
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62350264
78Pyruvate metabolism_Homo sapiens_hsa006200.62302016
79Arachidonic acid metabolism_Homo sapiens_hsa005900.61996039
80Olfactory transduction_Homo sapiens_hsa047400.60293034
81Autoimmune thyroid disease_Homo sapiens_hsa053200.59540105
82Histidine metabolism_Homo sapiens_hsa003400.57693418
83* Nucleotide excision repair_Homo sapiens_hsa034200.54914203
84Salivary secretion_Homo sapiens_hsa049700.53741847
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53380292
86Fat digestion and absorption_Homo sapiens_hsa049750.52614552
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50798494
88Cholinergic synapse_Homo sapiens_hsa047250.50183852
89Cocaine addiction_Homo sapiens_hsa050300.50176892
90Calcium signaling pathway_Homo sapiens_hsa040200.49962760
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49403739
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47887398
93Glycerolipid metabolism_Homo sapiens_hsa005610.47515133
94Renin secretion_Homo sapiens_hsa049240.47385618
95Base excision repair_Homo sapiens_hsa034100.47177319
96Mineral absorption_Homo sapiens_hsa049780.46775411
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44937300
98Linoleic acid metabolism_Homo sapiens_hsa005910.44912994
99Glutathione metabolism_Homo sapiens_hsa004800.44854606
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.42765772
101RNA degradation_Homo sapiens_hsa030180.41368546
102Asthma_Homo sapiens_hsa053100.41347472
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41339411
104Type I diabetes mellitus_Homo sapiens_hsa049400.40888209
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39998009
106Oocyte meiosis_Homo sapiens_hsa041140.39889443
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.39755019
108Mismatch repair_Homo sapiens_hsa034300.39217740
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.38945711
110Allograft rejection_Homo sapiens_hsa053300.36508198
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36010376
112RNA transport_Homo sapiens_hsa030130.34526916
113Hedgehog signaling pathway_Homo sapiens_hsa043400.34526059
114African trypanosomiasis_Homo sapiens_hsa051430.33335433
115Gap junction_Homo sapiens_hsa045400.33013516
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33006689
117Alcoholism_Homo sapiens_hsa050340.31968712
118Arginine and proline metabolism_Homo sapiens_hsa003300.31857865
119Epstein-Barr virus infection_Homo sapiens_hsa051690.31667662
120ABC transporters_Homo sapiens_hsa020100.30466665
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30207604
122Oxytocin signaling pathway_Homo sapiens_hsa049210.29885945
123Gastric acid secretion_Homo sapiens_hsa049710.27297794
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.26807463
125DNA replication_Homo sapiens_hsa030300.26533666
126Melanogenesis_Homo sapiens_hsa049160.25586232
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24366485
128Tyrosine metabolism_Homo sapiens_hsa003500.23056067
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20319526
130Insulin secretion_Homo sapiens_hsa049110.19782946
131Butanoate metabolism_Homo sapiens_hsa006500.18735525
132Non-homologous end-joining_Homo sapiens_hsa034500.18445151
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17526555
134Ras signaling pathway_Homo sapiens_hsa040140.17224282
135Fanconi anemia pathway_Homo sapiens_hsa034600.17009370
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.11464083
137GnRH signaling pathway_Homo sapiens_hsa049120.11240413
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.09759949
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.08004747

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