GTF2H2C_2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.91972306
2chromatin remodeling at centromere (GO:0031055)4.65576170
3CENP-A containing nucleosome assembly (GO:0034080)4.62741585
4DNA double-strand break processing (GO:0000729)4.24455371
5ribosome assembly (GO:0042255)4.07723055
6establishment of integrated proviral latency (GO:0075713)4.07201887
7histone exchange (GO:0043486)3.95756944
8mitotic metaphase plate congression (GO:0007080)3.94414525
9protein localization to kinetochore (GO:0034501)3.91046287
10regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.87872883
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.87796808
12DNA strand elongation involved in DNA replication (GO:0006271)3.85126846
13DNA ligation (GO:0006266)3.79208558
14metaphase plate congression (GO:0051310)3.73786974
15double-strand break repair via nonhomologous end joining (GO:0006303)3.73683695
16non-recombinational repair (GO:0000726)3.73683695
17DNA strand elongation (GO:0022616)3.71900850
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.69323309
19anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.69114183
20cullin deneddylation (GO:0010388)3.64848889
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62376726
22telomere maintenance via semi-conservative replication (GO:0032201)3.62058207
23spindle checkpoint (GO:0031577)3.60235104
24purine nucleobase biosynthetic process (GO:0009113)3.58885131
25IMP biosynthetic process (GO:0006188)3.57760091
26protein deneddylation (GO:0000338)3.57211768
27mitotic sister chromatid segregation (GO:0000070)3.54987346
28mitotic spindle checkpoint (GO:0071174)3.54496166
29DNA replication-independent nucleosome organization (GO:0034724)3.54451607
30DNA replication-independent nucleosome assembly (GO:0006336)3.54451607
31DNA replication checkpoint (GO:0000076)3.52671576
32nucleobase biosynthetic process (GO:0046112)3.51922263
33negative regulation of ligase activity (GO:0051352)3.50468443
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.50468443
35DNA catabolic process, exonucleolytic (GO:0000738)3.47979951
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47785701
37regulation of helicase activity (GO:0051095)3.46768800
38rRNA modification (GO:0000154)3.43952710
39regulation of mitotic spindle checkpoint (GO:1903504)3.42951393
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42951393
41maturation of 5.8S rRNA (GO:0000460)3.42739611
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39818727
43tRNA aminoacylation for protein translation (GO:0006418)3.39550794
44sister chromatid segregation (GO:0000819)3.39304766
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.38759660
46amino acid activation (GO:0043038)3.37915735
47tRNA aminoacylation (GO:0043039)3.37915735
48negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.35854989
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.35854989
50negative regulation of mitotic sister chromatid separation (GO:2000816)3.35854989
51negative regulation of sister chromatid segregation (GO:0033046)3.35854989
52negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.35854989
53telomere maintenance via recombination (GO:0000722)3.34856775
54somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34581851
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.34581851
56attachment of spindle microtubules to kinetochore (GO:0008608)3.34267700
57mitotic recombination (GO:0006312)3.34029035
58regulation of centriole replication (GO:0046599)3.34018175
59negative regulation of chromosome segregation (GO:0051985)3.32357334
60nuclear pore organization (GO:0006999)3.31822691
61kinetochore organization (GO:0051383)3.29326723
62somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.28350523
63somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.28350523
64isotype switching (GO:0045190)3.28350523
65respiratory chain complex IV assembly (GO:0008535)3.28259023
66mitotic nuclear envelope disassembly (GO:0007077)3.27709903
67DNA replication-dependent nucleosome organization (GO:0034723)3.25337669
68DNA replication-dependent nucleosome assembly (GO:0006335)3.25337669
69folic acid-containing compound biosynthetic process (GO:0009396)3.24681660
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23440374
71regulation of mitotic metaphase/anaphase transition (GO:0030071)3.23440374
72spindle assembly checkpoint (GO:0071173)3.22692158
73rRNA methylation (GO:0031167)3.22628586
74mitotic spindle assembly checkpoint (GO:0007094)3.20520891
75mitochondrial RNA metabolic process (GO:0000959)3.18215283
76establishment of viral latency (GO:0019043)3.17228560
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16483748
78nucleotide-excision repair, DNA gap filling (GO:0006297)3.15991286
79synapsis (GO:0007129)3.15703045
80replication fork processing (GO:0031297)3.14959232
81protein K6-linked ubiquitination (GO:0085020)3.14538852
82protein localization to chromosome, centromeric region (GO:0071459)3.14538179
83regulation of cellular amino acid metabolic process (GO:0006521)3.12701571
84negative regulation of DNA-dependent DNA replication (GO:2000104)3.12425978
85kinetochore assembly (GO:0051382)3.11195386
86IMP metabolic process (GO:0046040)3.10964472
87RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10790287
88establishment of chromosome localization (GO:0051303)3.10545243
89pseudouridine synthesis (GO:0001522)3.09931412
90negative regulation of DNA recombination (GO:0045910)3.08256921
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07525772
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07525772
93signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07525772
94histone mRNA metabolic process (GO:0008334)3.07418476
95regulation of chromosome segregation (GO:0051983)3.06487899
96regulation of sister chromatid segregation (GO:0033045)3.06017561
97regulation of mitotic sister chromatid separation (GO:0010965)3.06017561
98regulation of mitotic sister chromatid segregation (GO:0033047)3.06017561
99positive regulation of ligase activity (GO:0051351)3.05481670
100nuclear pore complex assembly (GO:0051292)3.04991529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.85163976
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.88896626
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.85156519
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.83050323
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.43369647
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09854350
7CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87171163
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.86265621
9ELK1_19687146_ChIP-ChIP_HELA_Human2.78551949
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68419078
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67789566
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59411071
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.57642446
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50993246
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50734496
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.49404763
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48606505
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.47692424
19VDR_23849224_ChIP-Seq_CD4+_Human2.41178787
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38893400
21FOXP3_21729870_ChIP-Seq_TREG_Human2.22107576
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18170842
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.16504951
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.14594915
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12398985
26DCP1A_22483619_ChIP-Seq_HELA_Human2.07585113
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07571928
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89443246
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.86465724
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86245021
31AR_21909140_ChIP-Seq_LNCAP_Human1.83053497
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82334277
33EWS_26573619_Chip-Seq_HEK293_Human1.77342540
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76687153
35ZNF274_21170338_ChIP-Seq_K562_Hela1.75998717
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.74981708
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.73886451
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71638235
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71621297
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70963003
41IGF1R_20145208_ChIP-Seq_DFB_Human1.70434051
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70016253
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68851936
44GABP_19822575_ChIP-Seq_HepG2_Human1.65863607
45FUS_26573619_Chip-Seq_HEK293_Human1.65658427
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57807511
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55015854
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52466652
49MYC_18940864_ChIP-ChIP_HL60_Human1.44781749
50TTF2_22483619_ChIP-Seq_HELA_Human1.44248308
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39092734
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36607288
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36459964
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35003475
55TAF15_26573619_Chip-Seq_HEK293_Human1.29887068
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.27202343
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25555915
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25302191
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22357785
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18897638
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15185078
62XRN2_22483619_ChIP-Seq_HELA_Human1.12746308
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10612311
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08583315
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07396152
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04607933
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.02547609
68P300_19829295_ChIP-Seq_ESCs_Human1.02305935
69VDR_22108803_ChIP-Seq_LS180_Human1.01789475
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01761243
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.00422422
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99463731
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96131319
74ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95052720
75KDM5A_27292631_Chip-Seq_BREAST_Human0.94982145
76ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91827863
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89741148
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89366669
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.88617377
80IRF1_19129219_ChIP-ChIP_H3396_Human0.88453617
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88237416
82TFEB_21752829_ChIP-Seq_HELA_Human0.85846261
83NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85714076
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.85643045
85NFE2_27457419_Chip-Seq_LIVER_Mouse0.85283662
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84575990
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.83339915
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82759328
89TP53_22573176_ChIP-Seq_HFKS_Human0.82690782
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81226019
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80471354
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.80154254
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78896006
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78413413
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77329692
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76843652
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74237144
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71451340
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.71332642
100ELF5_23300383_ChIP-Seq_T47D_Human0.70643264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.00074119
2MP0008058_abnormal_DNA_repair4.79845723
3MP0003693_abnormal_embryo_hatching4.32474622
4MP0008057_abnormal_DNA_replication4.19506188
5MP0003111_abnormal_nucleus_morphology3.75493913
6MP0004957_abnormal_blastocyst_morpholog3.75278076
7MP0008877_abnormal_DNA_methylation3.65437674
8MP0003077_abnormal_cell_cycle3.08829607
9MP0009697_abnormal_copulation3.01319944
10MP0003718_maternal_effect2.93180030
11MP0008007_abnormal_cellular_replicative2.92433947
12MP0003786_premature_aging2.80091046
13MP0008932_abnormal_embryonic_tissue2.54845372
14MP0000372_irregular_coat_pigmentation2.12004475
15MP0006035_abnormal_mitochondrial_morpho2.02424569
16MP0002102_abnormal_ear_morphology2.02198889
17MP0006072_abnormal_retinal_apoptosis1.85025815
18MP0003806_abnormal_nucleotide_metabolis1.80777805
19MP0010307_abnormal_tumor_latency1.78709730
20MP0001529_abnormal_vocalization1.72595541
21MP0006036_abnormal_mitochondrial_physio1.67204175
22MP0002254_reproductive_system_inflammat1.63212716
23MP0003186_abnormal_redox_activity1.62236751
24MP0001661_extended_life_span1.49110496
25MP0001730_embryonic_growth_arrest1.48924604
26MP0004147_increased_porphyrin_level1.43008852
27MP0003941_abnormal_skin_development1.40904827
28MP0006054_spinal_hemorrhage1.40431139
29MP0001697_abnormal_embryo_size1.38009982
30MP0001929_abnormal_gametogenesis1.36024310
31MP0000350_abnormal_cell_proliferation1.35922935
32MP0005075_abnormal_melanosome_morpholog1.34973642
33MP0003890_abnormal_embryonic-extraembry1.32895064
34MP0000358_abnormal_cell_content/1.30742288
35MP0005084_abnormal_gallbladder_morpholo1.30525736
36MP0008789_abnormal_olfactory_epithelium1.29526710
37MP0002938_white_spotting1.28005714
38MP0000647_abnormal_sebaceous_gland1.26402023
39MP0005253_abnormal_eye_physiology1.26239058
40MP0005408_hypopigmentation1.25712741
41MP0001293_anophthalmia1.24785443
42MP0002163_abnormal_gland_morphology1.21830901
43MP0002210_abnormal_sex_determination1.21356635
44MP0010352_gastrointestinal_tract_polyps1.19582601
45MP0003567_abnormal_fetal_cardiomyocyte1.18970486
46MP0001672_abnormal_embryogenesis/_devel1.18737335
47MP0005380_embryogenesis_phenotype1.18737335
48MP0003195_calcinosis1.14847982
49MP0000427_abnormal_hair_cycle1.13614970
50MP0000653_abnormal_sex_gland1.12637397
51MP0000313_abnormal_cell_death1.12294494
52MP0001764_abnormal_homeostasis1.11725767
53MP0005395_other_phenotype1.11141992
54MP0005379_endocrine/exocrine_gland_phen1.10218094
55MP0002090_abnormal_vision1.09642008
56MP0001145_abnormal_male_reproductive1.07454416
57MP0003121_genomic_imprinting1.03854427
58MP0003984_embryonic_growth_retardation1.03528487
59MP0002084_abnormal_developmental_patter1.03094280
60MP0002080_prenatal_lethality1.01740560
61MP0002088_abnormal_embryonic_growth/wei1.01025927
62MP0001119_abnormal_female_reproductive1.00303773
63MP0005551_abnormal_eye_electrophysiolog0.98460239
64MP0003937_abnormal_limbs/digits/tail_de0.93000966
65MP0000516_abnormal_urinary_system0.92049745
66MP0005367_renal/urinary_system_phenotyp0.92049745
67MP0002085_abnormal_embryonic_tissue0.90642070
68MP0005645_abnormal_hypothalamus_physiol0.89429603
69MP0002019_abnormal_tumor_incidence0.88829867
70MP0005332_abnormal_amino_acid0.86511844
71MP0003698_abnormal_male_reproductive0.85846707
72MP0002160_abnormal_reproductive_system0.85755013
73MP0003221_abnormal_cardiomyocyte_apopto0.85443574
74MP0001984_abnormal_olfaction0.84575046
75MP0002751_abnormal_autonomic_nervous0.83589986
76MP0005394_taste/olfaction_phenotype0.81465388
77MP0005499_abnormal_olfactory_system0.81465388
78MP0004197_abnormal_fetal_growth/weight/0.78892088
79MP0005389_reproductive_system_phenotype0.78769482
80MP0000569_abnormal_digit_pigmentation0.78319613
81MP0002233_abnormal_nose_morphology0.76432125
82MP0006292_abnormal_olfactory_placode0.76056803
83MP0002396_abnormal_hematopoietic_system0.75282866
84MP0009672_abnormal_birth_weight0.72982491
85MP0002837_dystrophic_cardiac_calcinosis0.72088277
86MP0009703_decreased_birth_body0.71875745
87MP0002736_abnormal_nociception_after0.71577062
88MP0001324_abnormal_eye_pigmentation0.71544628
89MP0005636_abnormal_mineral_homeostasis0.70077406
90MP0008995_early_reproductive_senescence0.68729666
91MP0008872_abnormal_physiological_respon0.67737716
92MP0005391_vision/eye_phenotype0.67276444
93MP0001286_abnormal_eye_development0.66546659
94MP0004215_abnormal_myocardial_fiber0.65760706
95MP0001188_hyperpigmentation0.65196249
96MP0003656_abnormal_erythrocyte_physiolo0.64667630
97MP0002086_abnormal_extraembryonic_tissu0.63968861
98MP0005647_abnormal_sex_gland0.63937259
99MP0001919_abnormal_reproductive_system0.63341146
100MP0001485_abnormal_pinna_reflex0.62347047

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.03159690
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.86075922
3Abnormality of chromosome stability (HP:0003220)3.64176712
4Meckel diverticulum (HP:0002245)3.57266275
5Abnormality of the ileum (HP:0001549)3.43650743
6Abnormality of the labia minora (HP:0012880)3.22090677
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.13208136
8Increased CSF lactate (HP:0002490)3.12624410
9Abnormality of the preputium (HP:0100587)3.10450379
10Acute necrotizing encephalopathy (HP:0006965)3.07666156
11Increased hepatocellular lipid droplets (HP:0006565)3.01897408
12Acute encephalopathy (HP:0006846)3.01095628
13Abnormality of glycolysis (HP:0004366)2.93825404
14Methylmalonic acidemia (HP:0002912)2.91565548
15Colon cancer (HP:0003003)2.88786140
16Lipid accumulation in hepatocytes (HP:0006561)2.82168767
17Abnormal lung lobation (HP:0002101)2.81497815
18Mitochondrial inheritance (HP:0001427)2.78666573
19Hepatocellular necrosis (HP:0001404)2.71571433
20Renal cortical cysts (HP:0000803)2.70088053
21Small intestinal stenosis (HP:0012848)2.69443704
22Duodenal stenosis (HP:0100867)2.69443704
23Progressive macrocephaly (HP:0004481)2.68361720
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68209305
25Abnormality of alanine metabolism (HP:0010916)2.68209305
26Hyperalaninemia (HP:0003348)2.68209305
27Increased serum pyruvate (HP:0003542)2.65820043
28Hyperglycinemia (HP:0002154)2.65443916
29Increased serum lactate (HP:0002151)2.64323363
30Abnormality of methionine metabolism (HP:0010901)2.62258587
31Neoplasm of the adrenal gland (HP:0100631)2.61949267
32Intestinal atresia (HP:0011100)2.60666839
33Abnormal mitochondria in muscle tissue (HP:0008316)2.59059496
34Hepatic necrosis (HP:0002605)2.56926710
35Abnormality of the duodenum (HP:0002246)2.52759002
36Type I transferrin isoform profile (HP:0003642)2.52296745
37Sloping forehead (HP:0000340)2.49790364
38Nephroblastoma (Wilms tumor) (HP:0002667)2.43859879
39Abnormality of serum amino acid levels (HP:0003112)2.33744922
40Abnormal protein glycosylation (HP:0012346)2.32542276
41Abnormal glycosylation (HP:0012345)2.32542276
42Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32542276
43Abnormal protein N-linked glycosylation (HP:0012347)2.32542276
44Embryonal renal neoplasm (HP:0011794)2.32098066
45Methylmalonic aciduria (HP:0012120)2.31553212
46Birth length less than 3rd percentile (HP:0003561)2.31142123
47Lactic acidosis (HP:0003128)2.30356480
48Volvulus (HP:0002580)2.29671181
49Cerebral edema (HP:0002181)2.29525923
50Pancreatic islet-cell hyperplasia (HP:0004510)2.29479898
51Medial flaring of the eyebrow (HP:0010747)2.22491771
52Ependymoma (HP:0002888)2.20746518
53Myelodysplasia (HP:0002863)2.18962794
54Rhabdomyosarcoma (HP:0002859)2.18824908
55Renal Fanconi syndrome (HP:0001994)2.16441856
56Glioma (HP:0009733)2.15878047
57Congenital primary aphakia (HP:0007707)2.08848080
58Pancreatic cysts (HP:0001737)2.08237728
59Medulloblastoma (HP:0002885)2.07947589
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05627308
61Pancreatic fibrosis (HP:0100732)2.03903490
62Progressive inability to walk (HP:0002505)2.03550803
63Nephrogenic diabetes insipidus (HP:0009806)2.03408638
64Clubbing of toes (HP:0100760)2.02055419
65Abnormality of glycine metabolism (HP:0010895)2.00754792
66Abnormality of serine family amino acid metabolism (HP:0010894)2.00754792
67Carpal bone hypoplasia (HP:0001498)1.98974252
68Microvesicular hepatic steatosis (HP:0001414)1.95328393
69True hermaphroditism (HP:0010459)1.94293684
70Horseshoe kidney (HP:0000085)1.94142485
71Lethargy (HP:0001254)1.92534752
72Reduced antithrombin III activity (HP:0001976)1.86305346
73Neoplasm of the adrenal cortex (HP:0100641)1.84990416
74Respiratory failure (HP:0002878)1.84666703
75Postnatal microcephaly (HP:0005484)1.84564827
76Gait imbalance (HP:0002141)1.84460444
77CNS demyelination (HP:0007305)1.84441730
78Pancytopenia (HP:0001876)1.83998745
79Degeneration of anterior horn cells (HP:0002398)1.78328222
80Abnormality of the anterior horn cell (HP:0006802)1.78328222
81Neoplasm of the colon (HP:0100273)1.77467141
82Astigmatism (HP:0000483)1.77368796
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76988919
84Ovarian neoplasm (HP:0100615)1.76271945
85Hyperglycinuria (HP:0003108)1.75911360
86Leukodystrophy (HP:0002415)1.75469012
87Abnormality of the carotid arteries (HP:0005344)1.75115994
88Respiratory difficulties (HP:0002880)1.73044135
89Genital tract atresia (HP:0001827)1.71805693
90Abnormality of the renal cortex (HP:0011035)1.70566401
91Abnormality of vitamin B metabolism (HP:0004340)1.70056133
92Optic disc pallor (HP:0000543)1.68005162
93Breast carcinoma (HP:0003002)1.67918952
94Abnormality of the pons (HP:0007361)1.67202135
95Abnormality of the astrocytes (HP:0100707)1.66229433
96Astrocytoma (HP:0009592)1.66229433
97Hypomagnesemia (HP:0002917)1.66148260
98Abnormal spermatogenesis (HP:0008669)1.64671428
99Clitoromegaly (HP:0000057)1.61375681
100Hypothermia (HP:0002045)1.61119941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.99199975
2EIF2AK33.39625851
3NEK13.30319738
4TRIM283.00581275
5SRPK12.97763953
6MST42.95278950
7TSSK62.91839397
8PBK2.82043126
9EIF2AK12.73019427
10TTK2.56616431
11ZAK2.47361164
12MAP4K22.44127151
13PLK32.26427300
14MKNK22.23498713
15VRK22.20494561
16NUAK12.16123666
17MKNK12.14720446
18CDC72.07144151
19PLK42.03864110
20WEE11.92256482
21BRSK21.90608360
22PDK21.89911124
23BCR1.84622118
24STK391.81854870
25VRK11.73724274
26FRK1.69241332
27TNIK1.64676882
28TAF11.54907997
29WNK31.54675500
30OXSR11.52787684
31STK161.43259836
32BMPR1B1.35247320
33PLK11.32335103
34ACVR1B1.30756769
35NME11.29159638
36ERBB31.28587157
37WNK41.18563891
38EIF2AK21.07219491
39ATR1.00615604
40SIK30.96663875
41CSNK1G10.94441997
42CSNK1G30.92029252
43STK38L0.90469921
44SCYL20.88443904
45BCKDK0.87625623
46CSNK1A1L0.85110068
47BRSK10.83870374
48STK30.83067235
49CHEK20.78249329
50FLT30.74335854
51PLK20.73894167
52AURKB0.72514926
53CCNB10.72415230
54GRK10.72223660
55ATM0.71752023
56PNCK0.71725886
57CSNK1G20.69276695
58STK40.67098646
59RPS6KA40.66300913
60LATS10.65057910
61PINK10.62295203
62CHEK10.61576440
63STK100.56633419
64NME20.51346954
65ADRBK20.50915488
66MAP3K40.50617713
67ERBB40.49981396
68PASK0.48454931
69ALK0.46645844
70INSRR0.43618971
71BRD40.43529269
72CLK10.43490710
73CDK70.42513092
74NEK20.42208683
75MAPK130.42054195
76CSNK2A10.40937314
77CSNK2A20.38632258
78MAP2K70.37808621
79FGFR10.36640487
80MAP3K120.35697063
81DYRK30.33868037
82PRKCI0.33690285
83MELK0.33273059
84MAPKAPK50.32482251
85PAK30.30904764
86DYRK20.30501810
87IRAK10.29727185
88AURKA0.29703922
89PRKCE0.29261304
90AKT30.28506025
91CDK10.27611326
92NEK60.27372443
93CDK30.27202823
94CSNK1E0.26318175
95RPS6KA50.24256497
96DAPK10.23889694
97NEK90.23649917
98PRKDC0.22984622
99NLK0.22745713
100TGFBR10.22423531

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.04901814
2Non-homologous end-joining_Homo sapiens_hsa034503.54663920
3Mismatch repair_Homo sapiens_hsa034303.54570451
4DNA replication_Homo sapiens_hsa030303.30894786
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.18948188
6Homologous recombination_Homo sapiens_hsa034403.07767065
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.84548943
8Protein export_Homo sapiens_hsa030602.71855752
9One carbon pool by folate_Homo sapiens_hsa006702.44190944
10* Nucleotide excision repair_Homo sapiens_hsa034202.29711953
11RNA polymerase_Homo sapiens_hsa030202.20176919
12Fanconi anemia pathway_Homo sapiens_hsa034602.19977596
13Propanoate metabolism_Homo sapiens_hsa006402.19017530
14RNA transport_Homo sapiens_hsa030132.18501323
15* Basal transcription factors_Homo sapiens_hsa030222.18221207
16Base excision repair_Homo sapiens_hsa034102.07356724
17RNA degradation_Homo sapiens_hsa030182.03199596
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00410157
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98129549
20Spliceosome_Homo sapiens_hsa030401.95043836
21Cell cycle_Homo sapiens_hsa041101.80875074
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77027696
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.73207123
24Oxidative phosphorylation_Homo sapiens_hsa001901.72943123
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71199693
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71185276
27Selenocompound metabolism_Homo sapiens_hsa004501.65104775
28Parkinsons disease_Homo sapiens_hsa050121.60791808
29Pyrimidine metabolism_Homo sapiens_hsa002401.56321739
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54215081
31Fatty acid elongation_Homo sapiens_hsa000621.52092504
32Pyruvate metabolism_Homo sapiens_hsa006201.46565820
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37749003
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25281693
35Steroid biosynthesis_Homo sapiens_hsa001001.24069641
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21915323
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19156682
38Purine metabolism_Homo sapiens_hsa002301.18412129
39Huntingtons disease_Homo sapiens_hsa050161.14873092
40Vitamin B6 metabolism_Homo sapiens_hsa007501.13690289
41Butanoate metabolism_Homo sapiens_hsa006501.04922007
42Carbon metabolism_Homo sapiens_hsa012001.00804979
43Folate biosynthesis_Homo sapiens_hsa007900.97321139
44mRNA surveillance pathway_Homo sapiens_hsa030150.95272342
45Oocyte meiosis_Homo sapiens_hsa041140.90041040
46Peroxisome_Homo sapiens_hsa041460.87816034
47Glutathione metabolism_Homo sapiens_hsa004800.87796457
48Biosynthesis of amino acids_Homo sapiens_hsa012300.87734124
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87218681
50Sulfur metabolism_Homo sapiens_hsa009200.86975491
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85884489
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84560830
53p53 signaling pathway_Homo sapiens_hsa041150.82567799
54Fatty acid metabolism_Homo sapiens_hsa012120.79622318
55Alzheimers disease_Homo sapiens_hsa050100.79159359
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78383194
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71882057
58Metabolic pathways_Homo sapiens_hsa011000.69909105
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65397662
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58971891
61N-Glycan biosynthesis_Homo sapiens_hsa005100.53706183
62Ribosome_Homo sapiens_hsa030100.53598487
63Fatty acid degradation_Homo sapiens_hsa000710.53117910
64beta-Alanine metabolism_Homo sapiens_hsa004100.51592755
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51339614
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50815144
67Tryptophan metabolism_Homo sapiens_hsa003800.50023240
68Caffeine metabolism_Homo sapiens_hsa002320.49539830
69Phototransduction_Homo sapiens_hsa047440.48734854
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.47109793
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46762405
72Vitamin digestion and absorption_Homo sapiens_hsa049770.45214645
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41332954
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38341517
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37991274
76Ether lipid metabolism_Homo sapiens_hsa005650.36687008
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.35847081
78Regulation of autophagy_Homo sapiens_hsa041400.35038554
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29841753
80Epstein-Barr virus infection_Homo sapiens_hsa051690.29571748
81Pentose phosphate pathway_Homo sapiens_hsa000300.29540823
82Collecting duct acid secretion_Homo sapiens_hsa049660.29307596
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.27533363
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26076391
85Sphingolipid metabolism_Homo sapiens_hsa006000.23468600
86Legionellosis_Homo sapiens_hsa051340.22692598
87Nitrogen metabolism_Homo sapiens_hsa009100.21437396
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21159453
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20504005
90TGF-beta signaling pathway_Homo sapiens_hsa043500.20428334
91Retinol metabolism_Homo sapiens_hsa008300.19914294
92Chemical carcinogenesis_Homo sapiens_hsa052040.18603128
93Arginine and proline metabolism_Homo sapiens_hsa003300.16781693
94Sulfur relay system_Homo sapiens_hsa041220.15970191
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15873633
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11428530
97Lysine degradation_Homo sapiens_hsa003100.10430306
98Herpes simplex infection_Homo sapiens_hsa051680.10403078
99Fat digestion and absorption_Homo sapiens_hsa049750.06664005
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06124183

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