GTF2H2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.33831542
2chromatin remodeling at centromere (GO:0031055)4.13034940
3CENP-A containing nucleosome assembly (GO:0034080)3.98931679
4histone exchange (GO:0043486)3.59426640
5exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54902186
6nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.52025457
7replication fork processing (GO:0031297)3.51592736
8RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.48258828
9protein K6-linked ubiquitination (GO:0085020)3.42966644
10DNA replication checkpoint (GO:0000076)3.42735689
11negative regulation of DNA-dependent DNA replication (GO:2000104)3.41101344
12establishment of protein localization to mitochondrial membrane (GO:0090151)3.39503355
13regulation of centriole replication (GO:0046599)3.39213097
14proteasome assembly (GO:0043248)3.38136360
15regulation of mitotic spindle checkpoint (GO:1903504)3.35794360
16regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.35794360
17histone mRNA metabolic process (GO:0008334)3.35018233
18somatic hypermutation of immunoglobulin genes (GO:0016446)3.29804794
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29804794
20DNA replication-dependent nucleosome organization (GO:0034723)3.28587138
21DNA replication-dependent nucleosome assembly (GO:0006335)3.28587138
22recombinational repair (GO:0000725)3.27360741
23double-strand break repair via homologous recombination (GO:0000724)3.26929073
24somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.25025855
25somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.25025855
26isotype switching (GO:0045190)3.25025855
27histone H2A acetylation (GO:0043968)3.24215865
28synapsis (GO:0007129)3.23764247
29prenylation (GO:0097354)3.23760803
30protein prenylation (GO:0018342)3.23760803
31kinetochore organization (GO:0051383)3.21076901
32centriole replication (GO:0007099)3.18395025
33DNA catabolic process, exonucleolytic (GO:0000738)3.18052649
34nucleobase biosynthetic process (GO:0046112)3.16324810
35pseudouridine synthesis (GO:0001522)3.15274290
36non-recombinational repair (GO:0000726)3.13180823
37double-strand break repair via nonhomologous end joining (GO:0006303)3.13180823
38respiratory chain complex IV assembly (GO:0008535)3.12815300
39regulation of DNA endoreduplication (GO:0032875)3.12439341
40ribosome assembly (GO:0042255)3.09141501
41regulation of helicase activity (GO:0051095)3.07564171
42DNA replication-independent nucleosome organization (GO:0034724)3.07248252
43DNA replication-independent nucleosome assembly (GO:0006336)3.07248252
44regulation of centrosome cycle (GO:0046605)3.04060091
45attachment of spindle microtubules to kinetochore (GO:0008608)3.03369331
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.01030419
47rRNA modification (GO:0000154)2.98634200
48meiotic chromosome segregation (GO:0045132)2.95346414
49resolution of meiotic recombination intermediates (GO:0000712)2.94983207
50maturation of 5.8S rRNA (GO:0000460)2.94227281
51rRNA methylation (GO:0031167)2.93565002
52regulation of centrosome duplication (GO:0010824)2.92539134
53DNA ligation (GO:0006266)2.92126216
54purine nucleobase biosynthetic process (GO:0009113)2.89094874
55somatic recombination of immunoglobulin gene segments (GO:0016447)2.88578680
56negative regulation of DNA recombination (GO:0045910)2.86951033
57transcription elongation from RNA polymerase I promoter (GO:0006362)2.85512710
58kinetochore assembly (GO:0051382)2.84373825
59mitochondrial RNA metabolic process (GO:0000959)2.84180720
60transcription from mitochondrial promoter (GO:0006390)2.83040330
61mitochondrial respiratory chain complex assembly (GO:0033108)2.81721662
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81119263
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.81119263
64NADH dehydrogenase complex assembly (GO:0010257)2.81119263
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80709741
66protein complex biogenesis (GO:0070271)2.80065883
67nuclear pore complex assembly (GO:0051292)2.79789127
68somatic diversification of immunoglobulins (GO:0016445)2.79297290
69metaphase plate congression (GO:0051310)2.77894974
70DNA strand elongation involved in DNA replication (GO:0006271)2.77792371
71water-soluble vitamin biosynthetic process (GO:0042364)2.76368148
72protein localization to kinetochore (GO:0034501)2.75714988
73termination of RNA polymerase I transcription (GO:0006363)2.74563498
74nuclear pore organization (GO:0006999)2.74037699
75spindle checkpoint (GO:0031577)2.72065420
76cytochrome complex assembly (GO:0017004)2.69342445
77DNA deamination (GO:0045006)2.69311788
78DNA-dependent DNA replication (GO:0006261)2.68148740
79telomere maintenance via semi-conservative replication (GO:0032201)2.66418398
80chaperone-mediated protein transport (GO:0072321)2.66306196
81spliceosomal snRNP assembly (GO:0000387)2.66203874
82telomere maintenance via recombination (GO:0000722)2.65356074
83sister chromatid segregation (GO:0000819)2.64178168
84DNA strand elongation (GO:0022616)2.63712153
85mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.63622796
86monoubiquitinated protein deubiquitination (GO:0035520)2.62555071
87mitotic sister chromatid cohesion (GO:0007064)2.62170956
88termination of RNA polymerase III transcription (GO:0006386)2.62152806
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.62152806
90mitotic spindle checkpoint (GO:0071174)2.62097169
91postreplication repair (GO:0006301)2.61854532
92DNA recombination (GO:0006310)2.61848390
93nucleotide-excision repair, DNA gap filling (GO:0006297)2.61262369
94protein neddylation (GO:0045116)2.61134870
95mitotic recombination (GO:0006312)2.60267824
96negative regulation of sister chromatid segregation (GO:0033046)2.59834581
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.59834581
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.59834581
99negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59834581
100negative regulation of mitotic sister chromatid separation (GO:2000816)2.59834581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.78335261
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54926518
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21272239
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.19656241
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.18926295
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.95941917
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.81703748
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.68417776
9ZNF274_21170338_ChIP-Seq_K562_Hela2.65626500
10ELK1_19687146_ChIP-ChIP_HELA_Human2.64384460
11EWS_26573619_Chip-Seq_HEK293_Human2.60696011
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48253356
13FUS_26573619_Chip-Seq_HEK293_Human2.47020781
14VDR_22108803_ChIP-Seq_LS180_Human2.45568903
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42060682
16IGF1R_20145208_ChIP-Seq_DFB_Human2.26349594
17TAF15_26573619_Chip-Seq_HEK293_Human2.18515882
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.12726498
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08332707
20VDR_23849224_ChIP-Seq_CD4+_Human2.04755564
21PADI4_21655091_ChIP-ChIP_MCF-7_Human1.96366760
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95620118
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89564244
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88658259
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84820598
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84485215
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84133820
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83416468
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83394463
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81145597
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.79248596
32P300_19829295_ChIP-Seq_ESCs_Human1.78039029
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.75777112
34FOXP3_21729870_ChIP-Seq_TREG_Human1.71788062
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65013010
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61599637
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61139992
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58507084
39MYC_18940864_ChIP-ChIP_HL60_Human1.58326530
40GBX2_23144817_ChIP-Seq_PC3_Human1.55554330
41ER_23166858_ChIP-Seq_MCF-7_Human1.54915119
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.53609645
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.49798100
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48411923
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47703044
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47331998
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36289590
48AR_21909140_ChIP-Seq_LNCAP_Human1.35619143
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.32274038
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30852372
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.28990176
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27324214
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24165888
54IRF1_19129219_ChIP-ChIP_H3396_Human1.22493767
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.20400783
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20283266
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17289710
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17071950
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.16457961
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15394544
61CBP_20019798_ChIP-Seq_JUKART_Human1.15394544
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14342987
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14046067
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13760755
65DCP1A_22483619_ChIP-Seq_HELA_Human1.13271431
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13144189
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12461851
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.09917834
69BCAT_22108803_ChIP-Seq_LS180_Human1.08743810
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06936190
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06224872
72TP53_22573176_ChIP-Seq_HFKS_Human1.05926228
73TTF2_22483619_ChIP-Seq_HELA_Human1.05271441
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04923093
75SOX2_19829295_ChIP-Seq_ESCs_Human1.03826746
76NANOG_19829295_ChIP-Seq_ESCs_Human1.03826746
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03367821
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.02538467
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02306904
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02103228
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.01579091
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01526001
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01018613
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00725114
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.00540651
86SMAD4_21799915_ChIP-Seq_A2780_Human0.99745023
87STAT3_23295773_ChIP-Seq_U87_Human0.98986556
88NANOG_18555785_Chip-Seq_ESCs_Mouse0.98721191
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97952903
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97930653
91MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97287571
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97181753
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96748971
94TCF4_22108803_ChIP-Seq_LS180_Human0.96505164
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94925033
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94925033
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.94317291
98GABP_19822575_ChIP-Seq_HepG2_Human0.93881640
99TCF4_23295773_ChIP-Seq_U87_Human0.93650395
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92863325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.58503071
2MP0008058_abnormal_DNA_repair3.87680088
3MP0010094_abnormal_chromosome_stability3.60742558
4MP0008877_abnormal_DNA_methylation3.12177099
5MP0009697_abnormal_copulation2.80760061
6MP0003693_abnormal_embryo_hatching2.80373017
7MP0003890_abnormal_embryonic-extraembry2.57690554
8MP0004957_abnormal_blastocyst_morpholog2.51774834
9MP0006072_abnormal_retinal_apoptosis2.35419660
10MP0000372_irregular_coat_pigmentation2.33950924
11MP0003718_maternal_effect2.27163061
12MP0002102_abnormal_ear_morphology2.23401464
13MP0003111_abnormal_nucleus_morphology2.12636688
14MP0003077_abnormal_cell_cycle2.06624572
15MP0006292_abnormal_olfactory_placode2.03417691
16MP0002938_white_spotting1.96477632
17MP0000569_abnormal_digit_pigmentation1.92887777
18MP0008007_abnormal_cellular_replicative1.87902985
19MP0003786_premature_aging1.87042861
20MP0005253_abnormal_eye_physiology1.72038630
21MP0003195_calcinosis1.71902706
22MP0001529_abnormal_vocalization1.69756658
23MP0005551_abnormal_eye_electrophysiolog1.63919333
24MP0002837_dystrophic_cardiac_calcinosis1.61672514
25MP0002736_abnormal_nociception_after1.56040507
26MP0008995_early_reproductive_senescence1.56019945
27MP0003136_yellow_coat_color1.55105110
28MP0008932_abnormal_embryonic_tissue1.53364539
29MP0003937_abnormal_limbs/digits/tail_de1.47277546
30MP0003121_genomic_imprinting1.43455872
31MP0001293_anophthalmia1.41012245
32MP0005084_abnormal_gallbladder_morpholo1.40680245
33MP0000631_abnormal_neuroendocrine_gland1.30523383
34MP0006035_abnormal_mitochondrial_morpho1.26585775
35MP0002210_abnormal_sex_determination1.24457736
36MP0001929_abnormal_gametogenesis1.21691738
37MP0004147_increased_porphyrin_level1.21535028
38MP0005174_abnormal_tail_pigmentation1.20342560
39MP0003941_abnormal_skin_development1.18110744
40MP0000427_abnormal_hair_cycle1.15980288
41MP0002234_abnormal_pharynx_morphology1.12672994
42MP0000653_abnormal_sex_gland1.10559270
43MP0005367_renal/urinary_system_phenotyp1.08970123
44MP0000516_abnormal_urinary_system1.08970123
45MP0001145_abnormal_male_reproductive1.08721955
46MP0001485_abnormal_pinna_reflex1.08644105
47MP0003567_abnormal_fetal_cardiomyocyte1.07934562
48MP0005075_abnormal_melanosome_morpholog1.07879125
49MP0004133_heterotaxia1.04952570
50MP0004215_abnormal_myocardial_fiber1.03671031
51MP0001968_abnormal_touch/_nociception1.03391452
52MP0002638_abnormal_pupillary_reflex1.03288705
53MP0001188_hyperpigmentation1.02984428
54MP0002160_abnormal_reproductive_system1.01920946
55MP0002751_abnormal_autonomic_nervous1.01782118
56MP0001697_abnormal_embryo_size1.00991509
57MP0005646_abnormal_pituitary_gland0.97713698
58MP0002084_abnormal_developmental_patter0.97635559
59MP0003119_abnormal_digestive_system0.96322719
60MP0003011_delayed_dark_adaptation0.95581320
61MP0003787_abnormal_imprinting0.94779836
62MP0001286_abnormal_eye_development0.94375075
63MP0004142_abnormal_muscle_tone0.94149847
64MP0003646_muscle_fatigue0.93911103
65MP0003698_abnormal_male_reproductive0.92503942
66MP0005391_vision/eye_phenotype0.91854700
67MP0005380_embryogenesis_phenotype0.90502009
68MP0001672_abnormal_embryogenesis/_devel0.90502009
69MP0001764_abnormal_homeostasis0.89812476
70MP0005408_hypopigmentation0.88872991
71MP0004197_abnormal_fetal_growth/weight/0.88247239
72MP0006036_abnormal_mitochondrial_physio0.87418897
73MP0008789_abnormal_olfactory_epithelium0.87139282
74MP0002233_abnormal_nose_morphology0.86960629
75MP0009703_decreased_birth_body0.84154700
76MP0005379_endocrine/exocrine_gland_phen0.83989378
77MP0003943_abnormal_hepatobiliary_system0.83820999
78MP0008961_abnormal_basal_metabolism0.83443896
79MP0002163_abnormal_gland_morphology0.82999364
80MP0002085_abnormal_embryonic_tissue0.82363730
81MP0005389_reproductive_system_phenotype0.80649747
82MP0008872_abnormal_physiological_respon0.80542295
83MP0001119_abnormal_female_reproductive0.80440058
84MP0000350_abnormal_cell_proliferation0.79908124
85MP0003880_abnormal_central_pattern0.79350007
86MP0002088_abnormal_embryonic_growth/wei0.78752777
87MP0000647_abnormal_sebaceous_gland0.78508551
88MP0005395_other_phenotype0.77494936
89MP0001324_abnormal_eye_pigmentation0.77387485
90MP0003984_embryonic_growth_retardation0.77172860
91MP0005645_abnormal_hypothalamus_physiol0.75873187
92MP0001984_abnormal_olfaction0.75315303
93MP0004145_abnormal_muscle_electrophysio0.74933616
94MP0002009_preneoplasia0.73934877
95MP0002282_abnormal_trachea_morphology0.73597948
96MP0001730_embryonic_growth_arrest0.72579345
97MP0002095_abnormal_skin_pigmentation0.71780619
98MP0002277_abnormal_respiratory_mucosa0.70771686
99MP0003755_abnormal_palate_morphology0.68389689
100MP0009046_muscle_twitch0.68132783

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.46443147
2Pancreatic fibrosis (HP:0100732)3.35636149
3Abnormality of chromosome stability (HP:0003220)2.99417886
4True hermaphroditism (HP:0010459)2.96848379
5Molar tooth sign on MRI (HP:0002419)2.96558604
6Abnormality of midbrain morphology (HP:0002418)2.96558604
7Nephronophthisis (HP:0000090)2.93855532
8Volvulus (HP:0002580)2.87507441
9Abnormality of the labia minora (HP:0012880)2.85375301
10Chromsome breakage (HP:0040012)2.82390850
11Increased hepatocellular lipid droplets (HP:0006565)2.78832450
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.76864247
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75483284
14Lipid accumulation in hepatocytes (HP:0006561)2.74411919
15Meckel diverticulum (HP:0002245)2.69020812
16Abnormality of the ileum (HP:0001549)2.67516832
17Intestinal atresia (HP:0011100)2.67082109
18Colon cancer (HP:0003003)2.62901403
19Abnormality of the renal cortex (HP:0011035)2.60029105
20Abnormality of the renal medulla (HP:0100957)2.57557503
21Medial flaring of the eyebrow (HP:0010747)2.51413997
22Renal cortical cysts (HP:0000803)2.48098354
23Congenital stationary night blindness (HP:0007642)2.44561275
24Increased CSF lactate (HP:0002490)2.43386706
25Birth length less than 3rd percentile (HP:0003561)2.37784610
26Acute necrotizing encephalopathy (HP:0006965)2.35057381
27Abnormality of alanine metabolism (HP:0010916)2.33458095
28Hyperalaninemia (HP:0003348)2.33458095
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33458095
30Abnormality of the pons (HP:0007361)2.30984175
31Sloping forehead (HP:0000340)2.29892680
32Abnormality of the preputium (HP:0100587)2.26765357
33Mitochondrial inheritance (HP:0001427)2.26195995
34Hypoplasia of the pons (HP:0012110)2.26137166
35Acute encephalopathy (HP:0006846)2.25297604
36Aplasia/Hypoplasia of the tibia (HP:0005772)2.18679397
37Methylmalonic acidemia (HP:0002912)2.14573432
38Small hand (HP:0200055)2.12509257
39Abnormality of the duodenum (HP:0002246)2.11589558
40Small intestinal stenosis (HP:0012848)2.09742378
41Duodenal stenosis (HP:0100867)2.09742378
42Progressive macrocephaly (HP:0004481)2.09495535
43Genital tract atresia (HP:0001827)2.06030653
44Congenital primary aphakia (HP:0007707)2.05587044
45Hypothermia (HP:0002045)2.04098320
46Abnormal lung lobation (HP:0002101)2.02690600
47Bile duct proliferation (HP:0001408)2.01061544
48Abnormal biliary tract physiology (HP:0012439)2.01061544
49Congenital, generalized hypertrichosis (HP:0004540)1.99869051
50Aplasia/Hypoplasia of the tongue (HP:0010295)1.98184627
51Nephroblastoma (Wilms tumor) (HP:0002667)1.94125077
52Gastrointestinal atresia (HP:0002589)1.94026118
53Abnormality of the anterior horn cell (HP:0006802)1.94026071
54Degeneration of anterior horn cells (HP:0002398)1.94026071
55Type I transferrin isoform profile (HP:0003642)1.93099242
56Gait imbalance (HP:0002141)1.92855989
57Embryonal renal neoplasm (HP:0011794)1.92737131
58Short tibia (HP:0005736)1.91566113
59Clubbing of toes (HP:0100760)1.90316928
60Vaginal atresia (HP:0000148)1.90301229
61Increased serum lactate (HP:0002151)1.90036678
623-Methylglutaconic aciduria (HP:0003535)1.88291919
63Type II lissencephaly (HP:0007260)1.86662414
64Hepatocellular necrosis (HP:0001404)1.86598756
65Nephrogenic diabetes insipidus (HP:0009806)1.86124546
66Abnormal mitochondria in muscle tissue (HP:0008316)1.85657133
67Dandy-Walker malformation (HP:0001305)1.83632980
68Poor coordination (HP:0002370)1.83410890
69Supernumerary spleens (HP:0009799)1.82951508
70Gaze-evoked nystagmus (HP:0000640)1.82785365
71Gonadotropin excess (HP:0000837)1.80750257
72Astigmatism (HP:0000483)1.80407232
73Anencephaly (HP:0002323)1.79093654
74Sclerocornea (HP:0000647)1.78938297
75Ectopic kidney (HP:0000086)1.78871909
76Myelodysplasia (HP:0002863)1.77140233
77Pendular nystagmus (HP:0012043)1.76667451
78Hepatic necrosis (HP:0002605)1.74869491
79Preaxial hand polydactyly (HP:0001177)1.74318307
80Tubular atrophy (HP:0000092)1.74261164
81Megaloblastic anemia (HP:0001889)1.74238211
82Bifid tongue (HP:0010297)1.73568024
83Chronic hepatic failure (HP:0100626)1.73239227
84Triphalangeal thumb (HP:0001199)1.72293711
85Abnormality of methionine metabolism (HP:0010901)1.72065233
86Renal Fanconi syndrome (HP:0001994)1.72064821
87Cystic liver disease (HP:0006706)1.71368089
88Postaxial foot polydactyly (HP:0001830)1.71296436
89Abnormality of serum amino acid levels (HP:0003112)1.71121013
90Attenuation of retinal blood vessels (HP:0007843)1.70119725
91Hyperglycinuria (HP:0003108)1.69988085
92Abolished electroretinogram (ERG) (HP:0000550)1.69840930
93Progressive inability to walk (HP:0002505)1.69093350
94Methylmalonic aciduria (HP:0012120)1.68566520
95Abnormality of macular pigmentation (HP:0008002)1.67702634
96Pancreatic islet-cell hyperplasia (HP:0004510)1.66847013
97Cerebellar dysplasia (HP:0007033)1.66775807
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65841491
99Cerebral edema (HP:0002181)1.65545153
100Optic nerve hypoplasia (HP:0000609)1.65523400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.03831535
2NUAK12.85660049
3BMPR1B2.78163715
4ZAK2.61008736
5BUB12.56091583
6BRSK22.53623224
7MKNK22.50334634
8MST42.50212508
9EIF2AK32.48971469
10CDC72.31193141
11MAP4K22.30159021
12TSSK62.26168184
13WEE12.23156723
14ACVR1B2.13969152
15WNK32.09793489
16SRPK12.02589785
17TRIM282.01274850
18MKNK11.98018461
19VRK11.94457830
20PLK31.88877155
21TAF11.88113537
22PLK41.81559701
23AKT31.81402280
24VRK21.75262959
25PNCK1.74223111
26TNIK1.70503855
27GRK11.61442738
28EIF2AK11.54227270
29NEK11.53866673
30STK391.46646071
31TTK1.35585798
32INSRR1.31485067
33OXSR11.29544048
34STK38L1.25152527
35NEK21.24153945
36STK31.22972833
37MAP3K41.21894194
38BRD41.21456828
39WNK41.12632532
40MAPK131.12424948
41LATS11.12006830
42CASK1.09062751
43PBK1.06471985
44ERBB31.04089895
45ADRBK21.03512374
46PLK11.00404499
47EIF2AK20.97756943
48BCR0.97645027
49PAK30.95230783
50ATR0.94995017
51STK160.93883745
52TLK10.91424817
53PLK20.85243548
54CHEK20.81934168
55FGFR20.80935063
56PINK10.79090062
57CSNK1G10.78903862
58TGFBR10.77796662
59DYRK30.77044688
60ATM0.76936308
61CCNB10.75734896
62MAP2K70.75042095
63NME10.74297202
64TEC0.73915354
65CAMK1G0.70022366
66CSNK1G30.65399377
67CSNK1A1L0.64767113
68PDK20.63622309
69CSNK1G20.61671227
70BRSK10.58196310
71CDK30.56714634
72CAMK1D0.56488782
73AURKB0.55827967
74NLK0.55050268
75CHEK10.54774934
76STK40.54377654
77PRKD30.52356634
78FGFR10.47801090
79PRKCE0.46756896
80CAMKK20.46249056
81MAP3K120.45420657
82TXK0.43895718
83CSNK1E0.40484135
84DYRK20.37481747
85PASK0.37063397
86CDK80.36717517
87CSNK2A10.35939777
88CSNK2A20.35390299
89MARK30.34165732
90RPS6KA40.33901517
91CDK10.33071678
92RPS6KA50.32379553
93ERBB40.31999469
94IRAK10.31387347
95MUSK0.29801284
96PRKCG0.29088219
97MAPKAPK50.29065751
98TAOK30.28972020
99OBSCN0.28960157
100CDK70.28176782

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.27945769
2Protein export_Homo sapiens_hsa030603.27246354
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11446197
4Mismatch repair_Homo sapiens_hsa034303.06058467
5Homologous recombination_Homo sapiens_hsa034403.05270053
6Proteasome_Homo sapiens_hsa030503.00791586
7* Basal transcription factors_Homo sapiens_hsa030222.92293150
8RNA polymerase_Homo sapiens_hsa030202.79474801
9DNA replication_Homo sapiens_hsa030302.67791552
10Fanconi anemia pathway_Homo sapiens_hsa034602.56696546
11RNA degradation_Homo sapiens_hsa030182.48945436
12One carbon pool by folate_Homo sapiens_hsa006702.30194903
13RNA transport_Homo sapiens_hsa030132.23786230
14* Nucleotide excision repair_Homo sapiens_hsa034202.21391017
15Propanoate metabolism_Homo sapiens_hsa006402.15122211
16Oxidative phosphorylation_Homo sapiens_hsa001902.14288180
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09520395
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04698402
19Spliceosome_Homo sapiens_hsa030401.99544907
20Parkinsons disease_Homo sapiens_hsa050121.92331488
21Selenocompound metabolism_Homo sapiens_hsa004501.84379435
22Base excision repair_Homo sapiens_hsa034101.81738880
23Phototransduction_Homo sapiens_hsa047441.52243021
24Cell cycle_Homo sapiens_hsa041101.51242070
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47769193
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46271041
27Huntingtons disease_Homo sapiens_hsa050161.44905010
28Pyrimidine metabolism_Homo sapiens_hsa002401.39527189
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37383301
30Butanoate metabolism_Homo sapiens_hsa006501.32458056
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32194745
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.31310433
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29911570
34Ribosome_Homo sapiens_hsa030101.29725947
35Purine metabolism_Homo sapiens_hsa002301.26921217
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18744376
37Nitrogen metabolism_Homo sapiens_hsa009101.15085097
38Pyruvate metabolism_Homo sapiens_hsa006201.07704255
39Alzheimers disease_Homo sapiens_hsa050101.05621635
40mRNA surveillance pathway_Homo sapiens_hsa030151.04964734
41Steroid biosynthesis_Homo sapiens_hsa001000.97747074
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96833329
43Tryptophan metabolism_Homo sapiens_hsa003800.87970525
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87969055
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87025032
46p53 signaling pathway_Homo sapiens_hsa041150.83859155
47Caffeine metabolism_Homo sapiens_hsa002320.83167419
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.81590939
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76655157
50Oocyte meiosis_Homo sapiens_hsa041140.76336769
51Linoleic acid metabolism_Homo sapiens_hsa005910.74692941
52Regulation of autophagy_Homo sapiens_hsa041400.73634188
53Vitamin digestion and absorption_Homo sapiens_hsa049770.72192358
54Peroxisome_Homo sapiens_hsa041460.71771888
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69877068
56Ether lipid metabolism_Homo sapiens_hsa005650.67793496
57TGF-beta signaling pathway_Homo sapiens_hsa043500.67211574
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64832265
59Olfactory transduction_Homo sapiens_hsa047400.63050355
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62216126
61Circadian rhythm_Homo sapiens_hsa047100.62013461
62Sulfur metabolism_Homo sapiens_hsa009200.61246858
63Metabolic pathways_Homo sapiens_hsa011000.61156261
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61032050
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59865085
66Taste transduction_Homo sapiens_hsa047420.55999695
67Hedgehog signaling pathway_Homo sapiens_hsa043400.55102399
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54956060
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51655216
70Vitamin B6 metabolism_Homo sapiens_hsa007500.51274047
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49642629
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48335483
73Retinol metabolism_Homo sapiens_hsa008300.47558760
74Fatty acid metabolism_Homo sapiens_hsa012120.46567207
75Lysine degradation_Homo sapiens_hsa003100.45695061
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.45463081
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45317411
78Folate biosynthesis_Homo sapiens_hsa007900.44022178
79Glutathione metabolism_Homo sapiens_hsa004800.43482256
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43096515
81Nicotine addiction_Homo sapiens_hsa050330.41816547
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.41526873
83Cardiac muscle contraction_Homo sapiens_hsa042600.41425106
84Fatty acid elongation_Homo sapiens_hsa000620.40441973
85beta-Alanine metabolism_Homo sapiens_hsa004100.39300703
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39253756
87Systemic lupus erythematosus_Homo sapiens_hsa053220.37727512
88Chemical carcinogenesis_Homo sapiens_hsa052040.36696107
89Alcoholism_Homo sapiens_hsa050340.28753348
90Serotonergic synapse_Homo sapiens_hsa047260.28432842
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25180966
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24700456
93Wnt signaling pathway_Homo sapiens_hsa043100.23679208
94Fatty acid degradation_Homo sapiens_hsa000710.22942109
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20156498
96Basal cell carcinoma_Homo sapiens_hsa052170.17106693
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16883245
98Epstein-Barr virus infection_Homo sapiens_hsa051690.15455821
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.15286087
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14483708

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