GTF2H2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.66642576
2proteasome assembly (GO:0043248)4.19934923
3cullin deneddylation (GO:0010388)4.14468809
4somatic hypermutation of immunoglobulin genes (GO:0016446)4.07999558
5somatic diversification of immune receptors via somatic mutation (GO:0002566)4.07999558
6protein deneddylation (GO:0000338)3.95276837
7chromatin remodeling at centromere (GO:0031055)3.88426379
8CENP-A containing nucleosome assembly (GO:0034080)3.72304794
9DNA replication checkpoint (GO:0000076)3.67518139
10establishment of protein localization to mitochondrial membrane (GO:0090151)3.67444532
11replication fork processing (GO:0031297)3.64180878
12water-soluble vitamin biosynthetic process (GO:0042364)3.61774563
13somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.59133808
14somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.59133808
15isotype switching (GO:0045190)3.59133808
16synapsis (GO:0007129)3.57317202
17double-strand break repair via nonhomologous end joining (GO:0006303)3.55567565
18non-recombinational repair (GO:0000726)3.55567565
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.55064057
20regulation of mitotic spindle checkpoint (GO:1903504)3.55064057
21ribosome assembly (GO:0042255)3.53755521
22purine nucleobase biosynthetic process (GO:0009113)3.53049250
23protein neddylation (GO:0045116)3.51156473
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49688725
25negative regulation of DNA-dependent DNA replication (GO:2000104)3.44469444
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44194736
27DNA deamination (GO:0045006)3.43892479
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.42283309
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40583752
30respiratory chain complex IV assembly (GO:0008535)3.38810411
31pseudouridine synthesis (GO:0001522)3.37176499
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.33398638
33histone exchange (GO:0043486)3.31319416
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30924722
35DNA catabolic process, exonucleolytic (GO:0000738)3.29362253
36nucleobase biosynthetic process (GO:0046112)3.27675467
37histone mRNA metabolic process (GO:0008334)3.26281878
38IMP biosynthetic process (GO:0006188)3.22047517
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20845727
40ATP synthesis coupled proton transport (GO:0015986)3.20845727
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20415075
42peptidyl-histidine modification (GO:0018202)3.19307207
43recombinational repair (GO:0000725)3.17752213
44establishment of integrated proviral latency (GO:0075713)3.17329705
45double-strand break repair via homologous recombination (GO:0000724)3.16201027
46DNA ligation (GO:0006266)3.15274489
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.14203876
48DNA replication-dependent nucleosome assembly (GO:0006335)3.13749553
49DNA replication-dependent nucleosome organization (GO:0034723)3.13749553
50somatic diversification of immunoglobulins (GO:0016445)3.10810360
51rRNA modification (GO:0000154)3.10316642
52somatic recombination of immunoglobulin gene segments (GO:0016447)3.09318824
53centriole replication (GO:0007099)3.06982339
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06379766
55negative regulation of ligase activity (GO:0051352)3.06379766
56metaphase plate congression (GO:0051310)3.05948588
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05112830
58maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04895905
59mitochondrial RNA metabolic process (GO:0000959)3.02648456
60mitochondrial respiratory chain complex assembly (GO:0033108)2.97020383
61maturation of 5.8S rRNA (GO:0000460)2.96591302
62lactate metabolic process (GO:0006089)2.96454175
63protein K6-linked ubiquitination (GO:0085020)2.96448336
64organelle disassembly (GO:1903008)2.95854912
65DNA damage response, detection of DNA damage (GO:0042769)2.93257895
66regulation of cellular amino acid metabolic process (GO:0006521)2.92183173
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91248209
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91248209
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90299015
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90299015
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90299015
72DNA strand elongation involved in DNA replication (GO:0006271)2.88332300
73cytochrome complex assembly (GO:0017004)2.87491902
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87269951
75mitotic metaphase plate congression (GO:0007080)2.87149027
76protein complex biogenesis (GO:0070271)2.87145085
77rRNA methylation (GO:0031167)2.84324445
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83833879
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83833879
80histone H2A acetylation (GO:0043968)2.83019172
81tRNA metabolic process (GO:0006399)2.81317865
82tRNA processing (GO:0008033)2.80688653
83DNA replication-independent nucleosome organization (GO:0034724)2.79910463
84DNA replication-independent nucleosome assembly (GO:0006336)2.79910463
85mitochondrial respiratory chain complex I assembly (GO:0032981)2.78056681
86NADH dehydrogenase complex assembly (GO:0010257)2.78056681
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78056681
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.77911294
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77911294
90regulation of centriole replication (GO:0046599)2.77357950
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.76822334
92termination of RNA polymerase III transcription (GO:0006386)2.76822334
93signal transduction involved in cell cycle checkpoint (GO:0072395)2.76760275
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76575252
95amino acid activation (GO:0043038)2.76490441
96tRNA aminoacylation (GO:0043039)2.76490441
97folic acid-containing compound biosynthetic process (GO:0009396)2.75752295
98IMP metabolic process (GO:0046040)2.75341433
99ubiquinone metabolic process (GO:0006743)2.74166982
100inner mitochondrial membrane organization (GO:0007007)2.74093105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.50510417
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44917246
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.73199369
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.44186140
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.33505629
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25556259
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.06997467
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81291647
9ELK1_19687146_ChIP-ChIP_HELA_Human2.74510572
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.63788227
11VDR_22108803_ChIP-Seq_LS180_Human2.54985083
12ZNF274_21170338_ChIP-Seq_K562_Hela2.52053280
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49946602
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45839438
15VDR_23849224_ChIP-Seq_CD4+_Human2.37561900
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.32300236
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31046010
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.27127038
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21633784
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20105524
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17342444
22FOXP3_21729870_ChIP-Seq_TREG_Human2.11840506
23* EWS_26573619_Chip-Seq_HEK293_Human2.11146103
24IGF1R_20145208_ChIP-Seq_DFB_Human2.02912087
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.02391926
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00336432
27FUS_26573619_Chip-Seq_HEK293_Human1.96758334
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90466086
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88865584
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85337803
31MYC_18940864_ChIP-ChIP_HL60_Human1.80691091
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76531208
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.71657822
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70075277
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60547155
36DCP1A_22483619_ChIP-Seq_HELA_Human1.58927225
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53367783
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53339205
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52211972
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52174455
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.47735980
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.46550449
43AR_21909140_ChIP-Seq_LNCAP_Human1.45152858
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44443109
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44140459
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43645529
47GABP_19822575_ChIP-Seq_HepG2_Human1.41943128
48P300_19829295_ChIP-Seq_ESCs_Human1.39524641
49TTF2_22483619_ChIP-Seq_HELA_Human1.36690400
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36303538
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34507786
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.27473860
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26850896
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23073637
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21685454
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20158206
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19114041
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18806729
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16368991
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14962320
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.14485183
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14399516
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13639243
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13322533
65TAF15_26573619_Chip-Seq_HEK293_Human1.10326608
66ER_23166858_ChIP-Seq_MCF-7_Human1.10064148
67TP53_22573176_ChIP-Seq_HFKS_Human1.10051094
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09634738
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09298612
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09234505
71IRF1_19129219_ChIP-ChIP_H3396_Human1.08927313
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08421275
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.07065110
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05666941
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05412211
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04493160
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.03109215
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01941570
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01412370
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01334696
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00511093
82SOX2_16153702_ChIP-ChIP_HESCs_Human0.99509719
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97826777
84GBX2_23144817_ChIP-Seq_PC3_Human0.95399318
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95158202
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.95158202
87KDM5A_27292631_Chip-Seq_BREAST_Human0.94598813
88XRN2_22483619_ChIP-Seq_HELA_Human0.94524000
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92546227
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91314109
91CBP_20019798_ChIP-Seq_JUKART_Human0.90795232
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90795232
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90617049
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90314079
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88477329
96SOX2_19829295_ChIP-Seq_ESCs_Human0.87181079
97NANOG_19829295_ChIP-Seq_ESCs_Human0.87181079
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.86946399
99BCAT_22108803_ChIP-Seq_LS180_Human0.86575492
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86414191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.46767908
2MP0010094_abnormal_chromosome_stability4.21030425
3MP0008877_abnormal_DNA_methylation3.40830370
4MP0003693_abnormal_embryo_hatching3.33986570
5MP0008057_abnormal_DNA_replication2.98483622
6MP0000372_irregular_coat_pigmentation2.69075726
7MP0004957_abnormal_blastocyst_morpholog2.65939888
8MP0006072_abnormal_retinal_apoptosis2.47793861
9MP0003111_abnormal_nucleus_morphology2.46309793
10MP0003718_maternal_effect2.46065816
11MP0008007_abnormal_cellular_replicative2.35935823
12MP0003786_premature_aging2.24376155
13MP0006292_abnormal_olfactory_placode2.19503151
14MP0003077_abnormal_cell_cycle2.19411268
15MP0009697_abnormal_copulation2.17748977
16MP0002102_abnormal_ear_morphology2.10919878
17MP0001188_hyperpigmentation1.94721646
18MP0002837_dystrophic_cardiac_calcinosis1.85047405
19MP0008932_abnormal_embryonic_tissue1.85014843
20MP0002163_abnormal_gland_morphology1.78720820
21MP0003195_calcinosis1.77949738
22MP0003890_abnormal_embryonic-extraembry1.67034591
23MP0002938_white_spotting1.61604342
24MP0005551_abnormal_eye_electrophysiolog1.61397834
25MP0005253_abnormal_eye_physiology1.61368885
26MP0006035_abnormal_mitochondrial_morpho1.60071640
27MP0002254_reproductive_system_inflammat1.59636036
28MP0003806_abnormal_nucleotide_metabolis1.56400122
29MP0004147_increased_porphyrin_level1.54341402
30MP0005084_abnormal_gallbladder_morpholo1.52220270
31MP0001293_anophthalmia1.49013698
32MP0005174_abnormal_tail_pigmentation1.45940235
33MP0001529_abnormal_vocalization1.43683382
34MP0005379_endocrine/exocrine_gland_phen1.42981686
35MP0005645_abnormal_hypothalamus_physiol1.41868727
36MP0002160_abnormal_reproductive_system1.38975868
37MP0002210_abnormal_sex_determination1.33478061
38MP0001929_abnormal_gametogenesis1.32478963
39MP0003011_delayed_dark_adaptation1.32078053
40MP0003186_abnormal_redox_activity1.31847702
41MP0008872_abnormal_physiological_respon1.28835797
42MP0006036_abnormal_mitochondrial_physio1.27695444
43MP0003121_genomic_imprinting1.25811199
44MP0003567_abnormal_fetal_cardiomyocyte1.24063814
45MP0002277_abnormal_respiratory_mucosa1.21949188
46MP0005389_reproductive_system_phenotype1.19628432
47MP0003136_yellow_coat_color1.17629559
48MP0003937_abnormal_limbs/digits/tail_de1.17322063
49MP0000653_abnormal_sex_gland1.14668490
50MP0001145_abnormal_male_reproductive1.14656607
51MP0001485_abnormal_pinna_reflex1.11852417
52MP0005075_abnormal_melanosome_morpholog1.10767780
53MP0002736_abnormal_nociception_after1.10166680
54MP0008789_abnormal_olfactory_epithelium1.09959560
55MP0008995_early_reproductive_senescence1.09238415
56MP0005367_renal/urinary_system_phenotyp1.08974903
57MP0000516_abnormal_urinary_system1.08974903
58MP0003941_abnormal_skin_development1.03271443
59MP0001764_abnormal_homeostasis1.01913994
60MP0010307_abnormal_tumor_latency1.00733982
61MP0003787_abnormal_imprinting1.00610830
62MP0004215_abnormal_myocardial_fiber0.98806884
63MP0001919_abnormal_reproductive_system0.98767882
64MP0002234_abnormal_pharynx_morphology0.95947723
65MP0001119_abnormal_female_reproductive0.95300460
66MP0001697_abnormal_embryo_size0.94937348
67MP0000631_abnormal_neuroendocrine_gland0.94878931
68MP0000569_abnormal_digit_pigmentation0.94081499
69MP0002876_abnormal_thyroid_physiology0.94036549
70MP0003283_abnormal_digestive_organ0.92852240
71MP0003119_abnormal_digestive_system0.91260179
72MP0005646_abnormal_pituitary_gland0.91175114
73MP0004133_heterotaxia0.90563510
74MP0002084_abnormal_developmental_patter0.89474532
75MP0001873_stomach_inflammation0.88110770
76MP0003698_abnormal_male_reproductive0.87346906
77MP0002751_abnormal_autonomic_nervous0.86639007
78MP0000427_abnormal_hair_cycle0.86019729
79MP0005395_other_phenotype0.84881498
80MP0001730_embryonic_growth_arrest0.82803362
81MP0000015_abnormal_ear_pigmentation0.82140850
82MP0008875_abnormal_xenobiotic_pharmacok0.80622961
83MP0000350_abnormal_cell_proliferation0.80094481
84MP0000358_abnormal_cell_content/0.79654478
85MP0005332_abnormal_amino_acid0.79516105
86MP0005220_abnormal_exocrine_pancreas0.78983852
87MP0003950_abnormal_plasma_membrane0.78767446
88MP0002090_abnormal_vision0.77713639
89MP0005410_abnormal_fertilization0.76297942
90MP0005391_vision/eye_phenotype0.76029656
91MP0000313_abnormal_cell_death0.75744560
92MP0005380_embryogenesis_phenotype0.75414685
93MP0001672_abnormal_embryogenesis/_devel0.75414685
94MP0003943_abnormal_hepatobiliary_system0.74058384
95MP0001324_abnormal_eye_pigmentation0.72168312
96MP0002233_abnormal_nose_morphology0.71043715
97MP0002085_abnormal_embryonic_tissue0.70535611
98MP0005394_taste/olfaction_phenotype0.70278661
99MP0005499_abnormal_olfactory_system0.70278661
100MP0005647_abnormal_sex_gland0.68674333

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.48416640
2Acute encephalopathy (HP:0006846)3.44986615
3Colon cancer (HP:0003003)3.20475626
4Increased hepatocellular lipid droplets (HP:0006565)3.07286976
5Ependymoma (HP:0002888)3.01151585
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.01095843
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.00700421
8Lipid accumulation in hepatocytes (HP:0006561)2.99916421
9Abnormality of chromosome stability (HP:0003220)2.99083264
10Mitochondrial inheritance (HP:0001427)2.98646240
11Increased CSF lactate (HP:0002490)2.97695389
12Progressive macrocephaly (HP:0004481)2.96632455
13Meckel diverticulum (HP:0002245)2.96112466
14Pancreatic cysts (HP:0001737)2.95697846
15Chromsome breakage (HP:0040012)2.92290501
16Abnormal mitochondria in muscle tissue (HP:0008316)2.92025046
17Abnormality of the ileum (HP:0001549)2.84352588
18Abnormality of the labia minora (HP:0012880)2.74692562
19Abnormality of the preputium (HP:0100587)2.63700636
20Methylmalonic acidemia (HP:0002912)2.57669093
21Pancreatic fibrosis (HP:0100732)2.51936276
22Hyperglycinemia (HP:0002154)2.50653611
23Abnormality of midbrain morphology (HP:0002418)2.47838440
24Molar tooth sign on MRI (HP:0002419)2.47838440
25Glioma (HP:0009733)2.43041187
26Renal cortical cysts (HP:0000803)2.42786828
27Abnormality of the pons (HP:0007361)2.39446335
283-Methylglutaconic aciduria (HP:0003535)2.39418032
29Cerebral edema (HP:0002181)2.38757716
30Abnormality of the renal cortex (HP:0011035)2.37403694
31Birth length less than 3rd percentile (HP:0003561)2.34082160
32Type I transferrin isoform profile (HP:0003642)2.29496311
33Medial flaring of the eyebrow (HP:0010747)2.29270956
34Increased serum lactate (HP:0002151)2.28453887
35Type II lissencephaly (HP:0007260)2.26905026
36Renal Fanconi syndrome (HP:0001994)2.23150145
37Duodenal stenosis (HP:0100867)2.20007693
38Small intestinal stenosis (HP:0012848)2.20007693
39Hepatocellular necrosis (HP:0001404)2.18927620
40Dyschromatopsia (HP:0007641)2.17916539
41Rhabdomyosarcoma (HP:0002859)2.17721220
42Abnormality of the astrocytes (HP:0100707)2.17397993
43Astrocytoma (HP:0009592)2.17397993
44Hypoplasia of the pons (HP:0012110)2.16735711
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16032223
46Abnormal protein N-linked glycosylation (HP:0012347)2.16032223
47Abnormal protein glycosylation (HP:0012346)2.16032223
48Abnormal glycosylation (HP:0012345)2.16032223
49Abnormality of serine family amino acid metabolism (HP:0010894)2.15036964
50Abnormality of glycine metabolism (HP:0010895)2.15036964
51Sloping forehead (HP:0000340)2.14444489
52Hepatic necrosis (HP:0002605)2.14248104
53Hyperglycinuria (HP:0003108)2.14236638
54Abnormality of the duodenum (HP:0002246)2.14188837
55Abnormality of methionine metabolism (HP:0010901)2.13564741
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13072028
57Nephronophthisis (HP:0000090)2.13005951
58True hermaphroditism (HP:0010459)2.12466363
59Abnormality of serum amino acid levels (HP:0003112)2.09500926
60Clubbing of toes (HP:0100760)2.09244607
61Congenital stationary night blindness (HP:0007642)2.06071057
62Lactic acidosis (HP:0003128)2.04257091
63Methylmalonic aciduria (HP:0012120)2.03691945
64Medulloblastoma (HP:0002885)2.03337266
65Optic disc pallor (HP:0000543)2.01964005
66Neoplasm of the adrenal gland (HP:0100631)1.91755159
67Abnormal lung lobation (HP:0002101)1.91557519
68Lethargy (HP:0001254)1.90284993
69Exertional dyspnea (HP:0002875)1.89251430
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88957813
71Abnormality of the renal medulla (HP:0100957)1.86855082
72Intestinal atresia (HP:0011100)1.84979865
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84581159
74Abnormality of alanine metabolism (HP:0010916)1.84581159
75Hyperalaninemia (HP:0003348)1.84581159
76Abolished electroretinogram (ERG) (HP:0000550)1.84044333
77Degeneration of anterior horn cells (HP:0002398)1.83473586
78Abnormality of the anterior horn cell (HP:0006802)1.83473586
79Volvulus (HP:0002580)1.80544941
80Myelodysplasia (HP:0002863)1.79924801
81Bile duct proliferation (HP:0001408)1.79547307
82Abnormal biliary tract physiology (HP:0012439)1.79547307
83Abnormality of vitamin B metabolism (HP:0004340)1.78771617
84Triphalangeal thumb (HP:0001199)1.77101520
85Tubulointerstitial nephritis (HP:0001970)1.75948763
86Agnosia (HP:0010524)1.75876606
87Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72715406
88Respiratory difficulties (HP:0002880)1.71457417
89Horseshoe kidney (HP:0000085)1.71439252
90Tubular atrophy (HP:0000092)1.70303621
91Pendular nystagmus (HP:0012043)1.69606176
92Ectopic kidney (HP:0000086)1.69135445
93Absent thumb (HP:0009777)1.69065540
94Postnatal microcephaly (HP:0005484)1.68646767
95Bifid tongue (HP:0010297)1.68462390
96Reduced antithrombin III activity (HP:0001976)1.68281750
97Congenital primary aphakia (HP:0007707)1.67844692
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67659105
99Pancytopenia (HP:0001876)1.67056754
100Breast carcinoma (HP:0003002)1.65560101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.45141234
2NUAK12.94085381
3VRK22.92289175
4ZAK2.78263158
5TSSK62.77268343
6EIF2AK32.56526192
7BRSK22.53897984
8TRIM282.42961102
9MST42.39502675
10PLK42.33048217
11BMPR1B2.32216167
12SRPK12.32013947
13MKNK22.31485874
14WEE12.27157683
15PLK32.13452799
16CDC72.11285939
17VRK12.09798264
18NEK12.08551624
19WNK32.06305320
20TTK2.03385605
21MKNK12.00851115
22EIF2AK11.96208492
23FRK1.86737134
24GRK11.78395791
25TAF11.75744989
26STK161.74131144
27ADRBK21.73346692
28PNCK1.70073629
29MAP4K21.68098933
30ACVR1B1.60437109
31PBK1.58634088
32TNIK1.47738527
33STK391.28874629
34BCR1.28716212
35WNK41.25118697
36PLK11.12815241
37MAP3K121.11246800
38PASK1.05916267
39CCNB11.00538752
40BRSK10.99296152
41TXK0.98935124
42ATR0.96977922
43STK38L0.92623795
44ERBB30.92415127
45TLK10.91573397
46EIF2AK20.90958653
47OXSR10.88238197
48AKT30.88030013
49CSNK1G10.83752111
50MAPK130.82791257
51STK30.82754152
52TEC0.82585694
53PRKD30.79714197
54PLK20.79557092
55PAK30.74967533
56PINK10.73992319
57CSNK1G30.73354585
58CHEK20.72305367
59ATM0.71716644
60CASK0.67950568
61CSNK1A1L0.65529811
62CSNK1G20.64976722
63FLT30.64784986
64NME10.64776948
65MAPKAPK50.64492968
66TGFBR10.62816674
67PRKCE0.61788817
68AURKB0.58383545
69ALK0.55891155
70TIE10.53429206
71NEK20.52417319
72CHEK10.51662982
73NLK0.51452851
74PDK20.48505913
75CSNK2A10.45282806
76STK40.44431128
77CAMKK20.43964672
78DYRK20.43762382
79CSNK2A20.41804957
80INSRR0.39586482
81BCKDK0.39283067
82FGFR10.37058601
83PRKCQ0.36770099
84MAP3K40.36685844
85CSNK1A10.34750671
86TAOK30.34418860
87PRKCG0.34016243
88ERBB40.32258556
89CSNK1E0.31599501
90DYRK30.31268110
91PRKCI0.31263494
92RPS6KA50.30159847
93PRKDC0.29876515
94MELK0.26429134
95CDK10.26390254
96DAPK10.25654966
97SIK30.24697915
98PRKCH0.23337268
99CDK70.22761767
100CDK30.19716499

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.04497778
2Non-homologous end-joining_Homo sapiens_hsa034503.09289113
3Mismatch repair_Homo sapiens_hsa034303.04079134
4Protein export_Homo sapiens_hsa030602.99746055
5Homologous recombination_Homo sapiens_hsa034402.97839198
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75803190
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56812811
8One carbon pool by folate_Homo sapiens_hsa006702.54324332
9DNA replication_Homo sapiens_hsa030302.48269705
10Fanconi anemia pathway_Homo sapiens_hsa034602.46453055
11Oxidative phosphorylation_Homo sapiens_hsa001902.37055178
12Basal transcription factors_Homo sapiens_hsa030222.35856373
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26726673
14RNA polymerase_Homo sapiens_hsa030202.26486998
15Nucleotide excision repair_Homo sapiens_hsa034202.07799855
16Parkinsons disease_Homo sapiens_hsa050122.05893039
17Propanoate metabolism_Homo sapiens_hsa006402.01102749
18RNA degradation_Homo sapiens_hsa030181.99798917
19RNA transport_Homo sapiens_hsa030131.98417377
20Selenocompound metabolism_Homo sapiens_hsa004501.82466479
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82257309
22Spliceosome_Homo sapiens_hsa030401.78713720
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71468917
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66573633
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57390659
26Ribosome_Homo sapiens_hsa030101.56759192
27Base excision repair_Homo sapiens_hsa034101.49410617
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.46960350
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46598114
30Butanoate metabolism_Homo sapiens_hsa006501.44562652
31Huntingtons disease_Homo sapiens_hsa050161.37936890
32Pyrimidine metabolism_Homo sapiens_hsa002401.34748549
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24095548
34Cell cycle_Homo sapiens_hsa041101.23835095
35Steroid biosynthesis_Homo sapiens_hsa001001.22316832
36Phototransduction_Homo sapiens_hsa047441.21029164
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18551452
38Caffeine metabolism_Homo sapiens_hsa002321.16829658
39Alzheimers disease_Homo sapiens_hsa050101.16475873
40Purine metabolism_Homo sapiens_hsa002301.10479093
41Vitamin B6 metabolism_Homo sapiens_hsa007501.10259080
42Tryptophan metabolism_Homo sapiens_hsa003800.99516029
43Fatty acid elongation_Homo sapiens_hsa000620.98864236
44Pyruvate metabolism_Homo sapiens_hsa006200.92643468
45Sulfur metabolism_Homo sapiens_hsa009200.92242360
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90911727
47mRNA surveillance pathway_Homo sapiens_hsa030150.90503238
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87600613
49Folate biosynthesis_Homo sapiens_hsa007900.86620263
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86575316
51Peroxisome_Homo sapiens_hsa041460.83810188
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.79702027
53p53 signaling pathway_Homo sapiens_hsa041150.71400722
54Metabolic pathways_Homo sapiens_hsa011000.71089120
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70014396
56Nitrogen metabolism_Homo sapiens_hsa009100.67498408
57Oocyte meiosis_Homo sapiens_hsa041140.66013615
58Regulation of autophagy_Homo sapiens_hsa041400.65466770
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64650987
60Glutathione metabolism_Homo sapiens_hsa004800.60754555
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59366484
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58660615
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58562970
64Fatty acid metabolism_Homo sapiens_hsa012120.58526791
65Linoleic acid metabolism_Homo sapiens_hsa005910.58278765
66Asthma_Homo sapiens_hsa053100.58077336
67Primary immunodeficiency_Homo sapiens_hsa053400.55905363
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53038233
69Carbon metabolism_Homo sapiens_hsa012000.49481950
70Vitamin digestion and absorption_Homo sapiens_hsa049770.49328481
71N-Glycan biosynthesis_Homo sapiens_hsa005100.48768606
72Fatty acid degradation_Homo sapiens_hsa000710.47623098
73Cardiac muscle contraction_Homo sapiens_hsa042600.47420553
74Type I diabetes mellitus_Homo sapiens_hsa049400.47006318
75beta-Alanine metabolism_Homo sapiens_hsa004100.46503063
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45145253
77Ether lipid metabolism_Homo sapiens_hsa005650.44562712
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44296578
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43370483
80Retinol metabolism_Homo sapiens_hsa008300.42148397
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39254167
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36980513
83Arginine and proline metabolism_Homo sapiens_hsa003300.36288225
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.35537188
85Systemic lupus erythematosus_Homo sapiens_hsa053220.34778204
86Biosynthesis of amino acids_Homo sapiens_hsa012300.34339971
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.33471647
88Antigen processing and presentation_Homo sapiens_hsa046120.30726105
89Chemical carcinogenesis_Homo sapiens_hsa052040.29709340
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.28179221
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27828790
92Olfactory transduction_Homo sapiens_hsa047400.27818186
93TGF-beta signaling pathway_Homo sapiens_hsa043500.27678770
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.27180372
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27174449
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26081076
97Allograft rejection_Homo sapiens_hsa053300.26001643
98Hedgehog signaling pathway_Homo sapiens_hsa043400.23809657
99Collecting duct acid secretion_Homo sapiens_hsa049660.22816067
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22649820

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