GTF2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)3.87726414
2piRNA metabolic process (GO:0034587)3.85826736
3regulation of chronic inflammatory response (GO:0002676)3.70970633
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.46235701
5platelet dense granule organization (GO:0060155)3.33851300
6negative regulation of interleukin-12 production (GO:0032695)3.33716316
7signal peptide processing (GO:0006465)3.23981563
8respiratory burst (GO:0045730)3.22638558
9proteasome assembly (GO:0043248)3.21680214
10antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19683373
11regulation of vitamin D biosynthetic process (GO:0060556)3.16780216
12regulation of RIG-I signaling pathway (GO:0039535)3.14979480
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.14695308
14chaperone-mediated protein transport (GO:0072321)3.13064482
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.10743420
16regulation of female gonad development (GO:2000194)3.05197289
17regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.00609377
18regulation of cytokine secretion involved in immune response (GO:0002739)2.99594788
19natural killer cell mediated cytotoxicity (GO:0042267)2.98487005
20natural killer cell mediated immunity (GO:0002228)2.98487005
21immunoglobulin mediated immune response (GO:0016064)2.97958282
22pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.97569071
23CENP-A containing nucleosome assembly (GO:0034080)2.94664908
24cullin deneddylation (GO:0010388)2.89087314
25protein K6-linked ubiquitination (GO:0085020)2.88600279
26negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.87436101
27response to peptidoglycan (GO:0032494)2.86780496
28protein deneddylation (GO:0000338)2.85519257
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80950359
30protein neddylation (GO:0045116)2.79308387
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78457233
32positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.77472961
33regulation of interferon-alpha production (GO:0032647)2.76569186
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75740677
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75740677
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75558594
37mitochondrial respiratory chain complex I assembly (GO:0032981)2.75558594
38NADH dehydrogenase complex assembly (GO:0010257)2.75558594
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75533634
40regulation of inflammatory response to antigenic stimulus (GO:0002861)2.74510230
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.72882579
42chromatin remodeling at centromere (GO:0031055)2.72412121
43histone mRNA metabolic process (GO:0008334)2.72028516
44signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71943722
45signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71943722
46signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71943722
47DNA deamination (GO:0045006)2.71554294
48ribosomal small subunit assembly (GO:0000028)2.71065471
49myeloid dendritic cell activation (GO:0001773)2.70805375
50positive regulation of alpha-beta T cell proliferation (GO:0046641)2.69967478
51positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69736281
52antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.67563431
53regulation of activation of Janus kinase activity (GO:0010533)2.65993192
54base-excision repair, AP site formation (GO:0006285)2.65966495
55NIK/NF-kappaB signaling (GO:0038061)2.65174643
56positive regulation of toll-like receptor signaling pathway (GO:0034123)2.65079774
57attachment of spindle microtubules to kinetochore (GO:0008608)2.64911515
58meiotic chromosome segregation (GO:0045132)2.64857837
59negative regulation of meiosis (GO:0045835)2.64083384
60positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.62711849
61cellular response to interferon-beta (GO:0035458)2.62689633
62response to xenobiotic stimulus (GO:0009410)2.62201715
63myeloid dendritic cell differentiation (GO:0043011)2.61339565
64regulation of alpha-beta T cell proliferation (GO:0046640)2.61228716
65positive regulation of humoral immune response (GO:0002922)2.60623394
66regulation of interleukin-12 production (GO:0032655)2.56784453
67protein-cofactor linkage (GO:0018065)2.55413061
68signal transduction involved in DNA integrity checkpoint (GO:0072401)2.55303886
69signal transduction involved in DNA damage checkpoint (GO:0072422)2.55303886
70establishment of protein localization to mitochondrial membrane (GO:0090151)2.54628415
71meiotic cell cycle (GO:0051321)2.54583131
72regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.54540589
73superoxide anion generation (GO:0042554)2.54464212
74DNA damage response, detection of DNA damage (GO:0042769)2.53875068
757-methylguanosine RNA capping (GO:0009452)2.53867073
76RNA capping (GO:0036260)2.53867073
77mitotic metaphase plate congression (GO:0007080)2.53854819
787-methylguanosine mRNA capping (GO:0006370)2.53501519
79negative regulation of growth of symbiont in host (GO:0044130)2.52271475
80negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.52271475
81modulation of growth of symbiont involved in interaction with host (GO:0044144)2.52271475
82regulation of growth of symbiont in host (GO:0044126)2.52271475
83regulation of immunoglobulin secretion (GO:0051023)2.51945061
84regulation of cellular amino acid metabolic process (GO:0006521)2.50201426
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.49800062
86negative regulation of ligase activity (GO:0051352)2.49152300
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49152300
88granulocyte activation (GO:0036230)2.49030830
89DNA methylation involved in gamete generation (GO:0043046)2.48575285
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48146587
91neural tube formation (GO:0001841)2.47990880
92DNA double-strand break processing (GO:0000729)2.46895804
93response to protozoan (GO:0001562)2.45637310
94female gamete generation (GO:0007292)2.45477856
95histone mRNA catabolic process (GO:0071044)2.45316359
96indole-containing compound catabolic process (GO:0042436)2.43881059
97indolalkylamine catabolic process (GO:0046218)2.43881059
98tryptophan catabolic process (GO:0006569)2.43881059
99maturation of 5.8S rRNA (GO:0000460)2.43616969
100telomere maintenance via recombination (GO:0000722)2.43462960
101positive regulation of interleukin-12 production (GO:0032735)2.43245454
102DNA catabolic process, exonucleolytic (GO:0000738)2.43116588
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.42238061
104intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.41623355
105positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.41283923
106protein complex biogenesis (GO:0070271)2.40026186
107positive regulation of NF-kappaB import into nucleus (GO:0042346)2.39926231
108histone exchange (GO:0043486)2.39729953
109regulation of interleukin-1 beta secretion (GO:0050706)2.39534392
110positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.38482899
111positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.37720857
112positive regulation of interferon-beta production (GO:0032728)2.37173639
113neutrophil activation (GO:0042119)2.36244799
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.35844937
115I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.35830865
116regulation of cilium movement (GO:0003352)2.35108437
117DNA replication-independent nucleosome assembly (GO:0006336)2.34548361
118DNA replication-independent nucleosome organization (GO:0034724)2.34548361
119positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.34298145
120B cell mediated immunity (GO:0019724)2.33835597
121establishment of chromosome localization (GO:0051303)2.33151495
122positive regulation of defense response to virus by host (GO:0002230)2.33141036
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.33135230
124leukocyte aggregation (GO:0070486)2.32666824
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.32581582
126regulation of defense response to virus by host (GO:0050691)2.32448880
127lipopolysaccharide-mediated signaling pathway (GO:0031663)2.32125433
128DNA replication checkpoint (GO:0000076)2.31773646
129mitochondrial respiratory chain complex assembly (GO:0033108)2.31239388
130Arp2/3 complex-mediated actin nucleation (GO:0034314)2.30918816
131purine-containing compound salvage (GO:0043101)2.30476685
132positive regulation of gamma-delta T cell activation (GO:0046645)2.30358709
133positive regulation of interleukin-1 beta secretion (GO:0050718)2.30034194
134response to interferon-beta (GO:0035456)2.29645785
135DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.28974006
136positive regulation of T-helper 1 type immune response (GO:0002827)2.28782111
137positive regulation of ligase activity (GO:0051351)2.28640590
138cytidine metabolic process (GO:0046087)2.28177689
139cytidine catabolic process (GO:0006216)2.28177689
140cytidine deamination (GO:0009972)2.28177689
141regulation of MHC class II biosynthetic process (GO:0045346)2.28063282
142regulation of T-helper cell differentiation (GO:0045622)2.28056113
143regulation of memory T cell differentiation (GO:0043380)2.27705496
144regulation of interleukin-8 biosynthetic process (GO:0045414)2.27475473
145positive regulation of interferon-alpha production (GO:0032727)2.27417889
146regulation of T-helper 1 cell differentiation (GO:0045625)2.26755595
147regulation of hypersensitivity (GO:0002883)2.26294583
148positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.25964444
149regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.25237469
150regulation of vitamin metabolic process (GO:0030656)2.25166001
151pyrimidine nucleotide catabolic process (GO:0006244)2.24950659
152neutrophil mediated immunity (GO:0002446)2.24787375
153regulation of fever generation (GO:0031620)2.24501862
154positive regulation of interleukin-1 secretion (GO:0050716)2.24084887
155natural killer cell activation involved in immune response (GO:0002323)2.23797815
156centriole replication (GO:0007099)2.23653543
157regulation of mitotic spindle checkpoint (GO:1903504)2.23385025
158regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.23385025
159defense response to protozoan (GO:0042832)2.22783991
160multicellular organism reproduction (GO:0032504)2.22371588
161positive regulation of DNA recombination (GO:0045911)2.21973779
162leukocyte mediated cytotoxicity (GO:0001909)2.21895137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.73285456
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.57025992
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56510879
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.51946782
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.35441054
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.19068571
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03537652
8* EST1_17652178_ChIP-ChIP_JURKAT_Human3.02565291
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93827968
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69476061
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62413427
12* VDR_23849224_ChIP-Seq_CD4+_Human2.49123113
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36260155
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31513522
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27579188
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25781056
17* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24918898
18HOXB4_20404135_ChIP-ChIP_EML_Mouse2.24533128
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22948289
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20474764
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20060747
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.15429427
23* ETS1_20019798_ChIP-Seq_JURKAT_Human2.13458126
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12660451
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11380879
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.09841550
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.08484301
28* ELK1_19687146_ChIP-ChIP_HELA_Human2.08139776
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07909745
30ZNF274_21170338_ChIP-Seq_K562_Hela2.05840671
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05171867
32VDR_22108803_ChIP-Seq_LS180_Human2.03305180
33* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99596638
34* DCP1A_22483619_ChIP-Seq_HELA_Human1.94160444
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.92577849
36SPI1_23547873_ChIP-Seq_NB4_Human1.90664100
37* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88797867
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86786478
39* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84845252
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83357839
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82831406
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77200758
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71320133
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70141952
45* FOXP3_21729870_ChIP-Seq_TREG_Human1.69104983
46* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68821202
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66307031
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66183379
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.65860359
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64824004
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62645605
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62543850
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61202386
54* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60775609
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57749334
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56575013
57GABP_19822575_ChIP-Seq_HepG2_Human1.55099716
58* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54254998
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47629815
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.46855100
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44385002
62IRF1_19129219_ChIP-ChIP_H3396_Human1.43783335
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42056382
64KAP1_22055183_ChIP-Seq_ESCs_Mouse1.38528157
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38071367
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36692125
67FUS_26573619_Chip-Seq_HEK293_Human1.33003201
68TAF15_26573619_Chip-Seq_HEK293_Human1.29964902
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29517839
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27513190
71IGF1R_20145208_ChIP-Seq_DFB_Human1.27116622
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25932470
73TTF2_22483619_ChIP-Seq_HELA_Human1.25577083
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.23680455
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23336454
76MYC_18940864_ChIP-ChIP_HL60_Human1.22110768
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22085102
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21977394
79XRN2_22483619_ChIP-Seq_HELA_Human1.21198803
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.20476644
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20154889
82SALL4_22934838_ChIP-ChIP_CD34+_Human1.19814792
83* TP53_22573176_ChIP-Seq_HFKS_Human1.18922680
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.17084208
85MYB_26560356_Chip-Seq_TH2_Human1.16429503
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.16320664
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14854592
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13866038
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.13549145
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13382236
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13098418
92* TFEB_21752829_ChIP-Seq_HELA_Human1.12584332
93AR_21909140_ChIP-Seq_LNCAP_Human1.11980135
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11798621
95GATA3_26560356_Chip-Seq_TH2_Human1.10662377
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09401904
97* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09156624
98P300_19829295_ChIP-Seq_ESCs_Human1.07309766
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05792362
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.03246881
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03235403
102* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03101746
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02861727
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02619424
105SOX2_19829295_ChIP-Seq_ESCs_Human1.01088932
106NANOG_19829295_ChIP-Seq_ESCs_Human1.01088932
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.00269385
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99022850
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97915259
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97732973
111HTT_18923047_ChIP-ChIP_STHdh_Human0.97370605
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97303853
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97032089
114ELK1_22589737_ChIP-Seq_MCF10A_Human0.96425211
115CRX_20693478_ChIP-Seq_RETINA_Mouse0.93597367
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93584644
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93049993
118GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93021602
119GBX2_23144817_ChIP-Seq_PC3_Human0.92924951
120THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92371961
121CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90512121
122LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90167394
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89428435
124ER_23166858_ChIP-Seq_MCF-7_Human0.87791607
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87628849
126* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87284365
127ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87160863
128SCL_19346495_ChIP-Seq_HPC-7_Human0.86682211
129GATA3_26560356_Chip-Seq_TH1_Human0.86653242
130SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86296662
131GATA3_27048872_Chip-Seq_THYMUS_Human0.86159520
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86026781
133CBP_20019798_ChIP-Seq_JUKART_Human0.86026781
134* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85686725
135* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85653472
136E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85611366
137MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85588462
138* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85509281
139FOXA1_25329375_ChIP-Seq_VCAP_Human0.85111987
140FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85111987
141NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84973627
142EWS_26573619_Chip-Seq_HEK293_Human0.84531559
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84383566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.27572266
2MP0003693_abnormal_embryo_hatching3.09802893
3MP0002148_abnormal_hypersensitivity_rea3.08956314
4MP0009785_altered_susceptibility_to3.04828302
5MP0003436_decreased_susceptibility_to2.79586809
6MP0005671_abnormal_response_to2.76750732
7MP0003806_abnormal_nucleotide_metabolis2.62786178
8MP0003303_peritoneal_inflammation2.60275533
9MP0005000_abnormal_immune_tolerance2.54898983
10MP0008057_abnormal_DNA_replication2.53971031
11MP0000569_abnormal_digit_pigmentation2.49427355
12MP0003718_maternal_effect2.44597424
13MP0010094_abnormal_chromosome_stability2.43092079
14MP0002419_abnormal_innate_immunity2.38573251
15MP0006082_CNS_inflammation2.32808622
16MP0003077_abnormal_cell_cycle2.30996287
17MP0000685_abnormal_immune_system2.22256656
18MP0005310_abnormal_salivary_gland2.22051136
19MP0002452_abnormal_antigen_presenting2.20279038
20MP0005025_abnormal_response_to2.11102266
21MP0002723_abnormal_immune_serum2.10734546
22MP0008007_abnormal_cellular_replicative2.08928577
23MP0001800_abnormal_humoral_immune2.04610631
24MP0002102_abnormal_ear_morphology2.03242743
25MP0008260_abnormal_autophagy1.99609301
26MP0005387_immune_system_phenotype1.98326149
27MP0001790_abnormal_immune_system1.98326149
28MP0001819_abnormal_immune_cell1.98306248
29MP0002420_abnormal_adaptive_immunity1.97418034
30MP0008877_abnormal_DNA_methylation1.91134665
31MP0004957_abnormal_blastocyst_morpholog1.89326734
32MP0009697_abnormal_copulation1.85482113
33MP0008058_abnormal_DNA_repair1.81717008
34MP0003763_abnormal_thymus_physiology1.77787881
35MP0003011_delayed_dark_adaptation1.76873526
36MP0005397_hematopoietic_system_phenotyp1.72128000
37MP0001545_abnormal_hematopoietic_system1.72128000
38MP0009333_abnormal_splenocyte_physiolog1.70290138
39MP0006292_abnormal_olfactory_placode1.68796963
40MP0003646_muscle_fatigue1.68721116
41MP0002398_abnormal_bone_marrow1.68688525
42MP0001764_abnormal_homeostasis1.66708508
43MP0010386_abnormal_urinary_bladder1.62699912
44MP0000490_abnormal_crypts_of1.58091387
45MP0000716_abnormal_immune_system1.56366801
46MP0003111_abnormal_nucleus_morphology1.56008945
47MP0002405_respiratory_system_inflammati1.53075956
48MP0001986_abnormal_taste_sensitivity1.50767048
49MP0003186_abnormal_redox_activity1.49956353
50MP0005408_hypopigmentation1.49218623
51MP0003724_increased_susceptibility_to1.46717872
52MP0005075_abnormal_melanosome_morpholog1.43665134
53MP0002163_abnormal_gland_morphology1.42106175
54MP0001845_abnormal_inflammatory_respons1.41422774
55MP0002638_abnormal_pupillary_reflex1.40293177
56MP0001119_abnormal_female_reproductive1.39220930
57MP0000372_irregular_coat_pigmentation1.37933097
58MP0000689_abnormal_spleen_morphology1.37182746
59MP0002429_abnormal_blood_cell1.37135286
60MP0002277_abnormal_respiratory_mucosa1.37133750
61MP0008932_abnormal_embryonic_tissue1.35168287
62MP0005084_abnormal_gallbladder_morpholo1.32181659
63MP0004510_myositis1.31761360
64MP0002006_tumorigenesis1.29631871
65MP0004782_abnormal_surfactant_physiolog1.29277490
66MP0002139_abnormal_hepatobiliary_system1.28746849
67MP0005464_abnormal_platelet_physiology1.28203904
68MP0009765_abnormal_xenobiotic_induced1.27025094
69MP0006035_abnormal_mitochondrial_morpho1.26895091
70MP0001533_abnormal_skeleton_physiology1.26119943
71MP0002722_abnormal_immune_system1.26060714
72MP0001929_abnormal_gametogenesis1.25639302
73MP0002138_abnormal_hepatobiliary_system1.23394777
74MP0004142_abnormal_muscle_tone1.21053332
75MP0003195_calcinosis1.20566954
76MP0003656_abnormal_erythrocyte_physiolo1.19796986
77MP0010155_abnormal_intestine_physiology1.19024429
78MP0001529_abnormal_vocalization1.18911219
79MP0006036_abnormal_mitochondrial_physio1.17686670
80MP0003183_abnormal_peptide_metabolism1.17001542
81MP0004808_abnormal_hematopoietic_stem1.16891434
82MP0002210_abnormal_sex_determination1.15287700
83MP0002693_abnormal_pancreas_physiology1.14167339
84MP0006072_abnormal_retinal_apoptosis1.13503904
85MP0004947_skin_inflammation1.12777168
86MP0009764_decreased_sensitivity_to1.11888431
87MP0005058_abnormal_lysosome_morphology1.10876041
88MP0002933_joint_inflammation1.09741294
89MP0002877_abnormal_melanocyte_morpholog1.09474571
90MP0002019_abnormal_tumor_incidence1.09091660
91MP0005253_abnormal_eye_physiology1.08989895
92MP0000703_abnormal_thymus_morphology1.06043204
93MP0008469_abnormal_protein_level1.04969935
94MP0000465_gastrointestinal_hemorrhage1.04316214
95MP0003786_premature_aging1.02933133
96MP0005266_abnormal_metabolism1.02145377
97MP0009840_abnormal_foam_cell1.01875114
98MP0001853_heart_inflammation1.01778039
99MP0002837_dystrophic_cardiac_calcinosis1.01615510
100MP0009763_increased_sensitivity_to0.99252909
101MP0002396_abnormal_hematopoietic_system0.98923318
102MP0000653_abnormal_sex_gland0.98115486
103MP0005451_abnormal_body_composition0.97680932
104MP0000350_abnormal_cell_proliferation0.94796105
105MP0000858_altered_metastatic_potential0.93105591
106MP0008875_abnormal_xenobiotic_pharmacok0.92811609
107MP0000343_altered_response_to0.92144193
108MP0008789_abnormal_olfactory_epithelium0.90875070
109MP0005376_homeostasis/metabolism_phenot0.90009986
110MP0005174_abnormal_tail_pigmentation0.89804166
111MP0001873_stomach_inflammation0.89795823
112MP0001324_abnormal_eye_pigmentation0.88832594
113MP0001905_abnormal_dopamine_level0.87693284
114MP0003699_abnormal_female_reproductive0.86714110
115MP0005379_endocrine/exocrine_gland_phen0.86247874
116MP0000313_abnormal_cell_death0.85406540
117MP0002132_abnormal_respiratory_system0.85368925
118MP0002332_abnormal_exercise_endurance0.84297254
119MP0000371_diluted_coat_color0.82244435
120MP0005410_abnormal_fertilization0.81998599
121MP0003866_abnormal_defecation0.81449106
122MP0000358_abnormal_cell_content/0.81356220
123MP0003221_abnormal_cardiomyocyte_apopto0.81214246
124MP0005395_other_phenotype0.79981865
125MP0003448_altered_tumor_morphology0.79332313
126MP0005085_abnormal_gallbladder_physiolo0.79284359
127MP0001145_abnormal_male_reproductive0.77555289
128MP0005390_skeleton_phenotype0.77235901
129MP0008873_increased_physiological_sensi0.76071227
130MP0008995_early_reproductive_senescence0.74755167
131MP0005365_abnormal_bile_salt0.74360577
132MP0003252_abnormal_bile_duct0.73640489
133MP0010307_abnormal_tumor_latency0.71716492
134MP0003943_abnormal_hepatobiliary_system0.70420626
135MP0002095_abnormal_skin_pigmentation0.69825764
136MP0008004_abnormal_stomach_pH0.69812372
137MP0005164_abnormal_response_to0.69033620
138MP0002998_abnormal_bone_remodeling0.68768140
139MP0005647_abnormal_sex_gland0.68631405
140MP0000015_abnormal_ear_pigmentation0.68565745

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.41036699
2Recurrent bacterial skin infections (HP:0005406)4.22756183
3Birth length less than 3rd percentile (HP:0003561)3.63531293
4Eczematoid dermatitis (HP:0000976)3.55652785
5Optic neuritis (HP:0100653)3.21687804
6Retrobulbar optic neuritis (HP:0100654)3.21687804
7Parakeratosis (HP:0001036)3.07661854
8Recurrent gram-negative bacterial infections (HP:0005420)3.06095751
9Myositis (HP:0100614)3.05113146
10Abnormality of macrophages (HP:0004311)3.03116788
11Mediastinal lymphadenopathy (HP:0100721)3.02600688
12Aplastic anemia (HP:0001915)3.01006880
13Chromsome breakage (HP:0040012)2.93925703
14Exertional dyspnea (HP:0002875)2.93156543
15Hepatocellular necrosis (HP:0001404)2.90963450
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78882766
17Increased hepatocellular lipid droplets (HP:0006565)2.74308382
18Orchitis (HP:0100796)2.67332651
19Increased IgM level (HP:0003496)2.63308190
20Poor head control (HP:0002421)2.63089513
21Mitochondrial inheritance (HP:0001427)2.62002946
22Type I transferrin isoform profile (HP:0003642)2.61575102
23Molar tooth sign on MRI (HP:0002419)2.59937368
24Abnormality of midbrain morphology (HP:0002418)2.59937368
25Elevated erythrocyte sedimentation rate (HP:0003565)2.56488111
26Stomatitis (HP:0010280)2.54342873
27Albinism (HP:0001022)2.50932873
28Acute encephalopathy (HP:0006846)2.49691668
29Hepatic necrosis (HP:0002605)2.47942014
30Petechiae (HP:0000967)2.43060091
31Pancreatic cysts (HP:0001737)2.41836341
32Vasculitis (HP:0002633)2.39888700
33Recurrent skin infections (HP:0001581)2.39434567
34Renal Fanconi syndrome (HP:0001994)2.38720094
35Acute necrotizing encephalopathy (HP:0006965)2.37878418
36Prostate neoplasm (HP:0100787)2.33885053
37Recurrent pneumonia (HP:0006532)2.32622695
38Abnormal protein glycosylation (HP:0012346)2.31962406
39Abnormal glycosylation (HP:0012345)2.31962406
40Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31962406
41Abnormal protein N-linked glycosylation (HP:0012347)2.31962406
42Breast hypoplasia (HP:0003187)2.30801508
43Irregular epiphyses (HP:0010582)2.30420227
44Lipid accumulation in hepatocytes (HP:0006561)2.30007432
45Hypoplasia of the fovea (HP:0007750)2.27825562
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.27825562
47Hypothermia (HP:0002045)2.22439948
48Agnosia (HP:0010524)2.22017118
49Vacuolated lymphocytes (HP:0001922)2.16687142
503-Methylglutaconic aciduria (HP:0003535)2.14881130
51Abnormal mitochondria in muscle tissue (HP:0008316)2.14773407
52Small epiphyses (HP:0010585)2.14475940
53Flat capital femoral epiphysis (HP:0003370)2.12963705
54Nausea (HP:0002018)2.12638324
55True hermaphroditism (HP:0010459)2.11405785
56Pancreatic fibrosis (HP:0100732)2.11332883
57Keratoconjunctivitis (HP:0001096)2.11067310
58Recurrent fungal infections (HP:0002841)2.09963441
59Chronic mucocutaneous candidiasis (HP:0002728)2.09850467
60Recurrent cutaneous fungal infections (HP:0011370)2.09850467
61Increased CSF lactate (HP:0002490)2.08337450
62IgM deficiency (HP:0002850)2.07707842
63Abnormality of glycolipid metabolism (HP:0010969)2.03239776
64Abnormality of liposaccharide metabolism (HP:0010968)2.03239776
65Abnormality of glycosphingolipid metabolism (HP:0004343)2.03239776
66Encephalitis (HP:0002383)2.00268519
67Generalized aminoaciduria (HP:0002909)1.98531058
68Carpal bone hypoplasia (HP:0001498)1.97882424
69Autoimmune hemolytic anemia (HP:0001890)1.97084298
70Recurrent viral infections (HP:0004429)1.96770637
71Myelodysplasia (HP:0002863)1.95841479
72Autoimmune thrombocytopenia (HP:0001973)1.95520066
73Abnormal hair whorl (HP:0010721)1.94440001
74Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.93725541
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93465446
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.92770913
77Medial flaring of the eyebrow (HP:0010747)1.92281865
78Disinhibition (HP:0000734)1.92063740
79Reticulocytopenia (HP:0001896)1.91788123
80Chronic hepatic failure (HP:0100626)1.90918502
81Reduced antithrombin III activity (HP:0001976)1.90855596
82Leukocytosis (HP:0001974)1.90219873
83Male infertility (HP:0003251)1.90203621
84Obstructive lung disease (HP:0006536)1.89451511
85Chronic obstructive pulmonary disease (HP:0006510)1.89451511
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89020995
87Abnormal biliary tract physiology (HP:0012439)1.88599813
88Bile duct proliferation (HP:0001408)1.88599813
89Abnormality of chromosome stability (HP:0003220)1.88574248
90Increased serum lactate (HP:0002151)1.88492844
91Abnormality of renal resorption (HP:0011038)1.88149281
92Meningitis (HP:0001287)1.87802408
93Abnormality of T cells (HP:0002843)1.87598437
94Oral leukoplakia (HP:0002745)1.86976894
95Gait imbalance (HP:0002141)1.86801331
96Respiratory difficulties (HP:0002880)1.85666354
97Abnormality of the labia minora (HP:0012880)1.85152855
98Abnormality of the preputium (HP:0100587)1.84912109
99Basal ganglia calcification (HP:0002135)1.84433515
100Progressive macrocephaly (HP:0004481)1.84349505
101T lymphocytopenia (HP:0005403)1.84151216
102Metaphyseal dysplasia (HP:0100255)1.84136810
103Cerebral edema (HP:0002181)1.83545671
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82128582
105Abnormality of alanine metabolism (HP:0010916)1.82128582
106Hyperalaninemia (HP:0003348)1.82128582
107Recurrent lower respiratory tract infections (HP:0002783)1.82004401
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81850593
109Nephrogenic diabetes insipidus (HP:0009806)1.81539423
110Eosinophilia (HP:0001880)1.81367286
111Hypergonadotropic hypogonadism (HP:0000815)1.81099644
112Optic disc pallor (HP:0000543)1.81021144
113Keratoconjunctivitis sicca (HP:0001097)1.80788022
114Thrombocytosis (HP:0001894)1.80577243
115Abnormality of the fovea (HP:0000493)1.80167996
116Neutropenia (HP:0001875)1.79745427
117Abnormality of T cell physiology (HP:0011840)1.79472796
118Abnormality of T cell number (HP:0011839)1.79208096
119B lymphocytopenia (HP:0010976)1.79115293
120Abnormality of the anterior horn cell (HP:0006802)1.78683637
121Degeneration of anterior horn cells (HP:0002398)1.78683637
122Lymphopenia (HP:0001888)1.78388691
123Short tibia (HP:0005736)1.77849877
124Bone marrow hypocellularity (HP:0005528)1.77788267
125Gangrene (HP:0100758)1.77655556
126Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77499122
127IgG deficiency (HP:0004315)1.77047189
128Congenital primary aphakia (HP:0007707)1.76372175
129Abnormality of cells of the lymphoid lineage (HP:0012140)1.76183332
130Abnormality of cells of the erythroid lineage (HP:0012130)1.75873726
131Polyneuropathy (HP:0001271)1.75493481
132Posterior subcapsular cataract (HP:0007787)1.75220519
133Pulmonary infiltrates (HP:0002113)1.73762379
134Abnormal number of erythroid precursors (HP:0012131)1.73510603
135Abnormality of eosinophils (HP:0001879)1.72960619
136Rhinitis (HP:0012384)1.72632766
137Type 2 muscle fiber atrophy (HP:0003554)1.71881603
138Abnormality of the prostate (HP:0008775)1.71840984
139Abnormality of B cell number (HP:0010975)1.70161385
140Abnormal delayed hypersensitivity skin test (HP:0002963)1.69972832
141Mutism (HP:0002300)1.68982117
142Abolished electroretinogram (ERG) (HP:0000550)1.67820348
143Lactic acidosis (HP:0003128)1.67094662
144Abnormality of the basal ganglia (HP:0002134)1.66086466
145Hypokinesia (HP:0002375)1.65790173
146Abnormality of the heme biosynthetic pathway (HP:0010472)1.64407963
147Stomach cancer (HP:0012126)1.63551797
148Atrophy/Degeneration involving motor neurons (HP:0007373)1.63246722
149Increased serum pyruvate (HP:0003542)1.63244416
150CNS demyelination (HP:0007305)1.62413537
151Nephronophthisis (HP:0000090)1.62269499
152Neoplasm of the tracheobronchial system (HP:0100552)1.60885358
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.60772193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR23.91056519
2MAP4K23.33511352
3PLK43.04465623
4TAOK22.74624840
5MOS2.67592122
6TAOK32.65666439
7EIF2AK32.61409530
8MAP3K142.50721542
9PBK2.50312192
10PIM22.31407606
11EIF2AK12.29243160
12NME22.26689306
13IRAK42.14573977
14NUAK12.07240768
15TXK1.97151047
16BUB11.93018349
17SIK31.87026564
18EPHA31.82750724
19RIPK41.81111858
20TBK11.74334522
21ARAF1.73243250
22MAP3K61.72511277
23IRAK31.72131149
24MST41.69297206
25CDK81.66937784
26TEC1.66484012
27TRIM281.66250461
28CDC71.59526861
29IKBKB1.53959353
30BMPR1B1.53305598
31ACVR1B1.52621700
32NEK11.40954380
33VRK11.39895422
34JAK31.37895835
35MAP3K121.37491721
36IKBKE1.36700909
37WNK31.31325294
38MUSK1.30928373
39IRAK11.30493640
40BRAF1.27171168
41MAP2K31.26324000
42EIF2AK21.25085187
43STK101.24297872
44BCR1.23215601
45STK161.22505876
46MAP4K11.21105647
47MAP2K61.20153441
48PIM11.19558189
49PASK1.18295587
50ADRBK21.16674061
51WEE11.15344046
52MAP3K31.10858156
53TLK11.10149312
54STK41.05970817
55MATK1.05373565
56KIT1.04344433
57BTK1.02128742
58BRSK21.01794240
59BLK1.00960872
60ERBB41.00566818
61TSSK60.98684381
62ZAP700.97779354
63PDK20.96479028
64DYRK20.93205591
65NLK0.92480246
66FRK0.91467098
67SRPK10.90342873
68SYK0.88370179
69CHUK0.87210544
70YES10.86226620
71PINK10.85748764
72DYRK30.83806008
73BRD40.82997477
74GRK70.82734152
75TESK10.82017761
76TAF10.79738876
77ZAK0.79226852
78AURKB0.79019148
79STK30.78482932
80CSK0.77099125
81PLK10.76956082
82TIE10.76184202
83TGFBR10.75743204
84MAP3K90.74999456
85MELK0.74763905
86ABL20.74060597
87TAOK10.72755103
88RAF10.72353625
89ITK0.71449656
90LYN0.71418088
91STK38L0.68584117
92CSNK1G20.67471717
93FGR0.66292922
94ATR0.65505090
95NME10.65499225
96MAP3K40.64317566
97TYK20.64050521
98CAMKK20.62724295
99CDK90.62395631
100TTK0.62349653
101STK240.61079558
102RPS6KA40.60934357
103CCNB10.60252925
104OXSR10.59560208
105AURKA0.59536103
106ERBB30.59482262
107PLK20.59363027
108MARK30.58600422
109PRKCQ0.58272488
110CHEK20.56972692
111NEK20.56699835
112RPS6KA50.56348019
113TRPM70.55532500
114MAP2K70.55230308
115MAPK130.53659593
116LCK0.53105699
117CDK70.52896388
118CSNK1G10.52281741
119NEK90.48748952
120AKT30.48104132
121PNCK0.47625875
122CSNK1A1L0.46639060
123PAK30.45267911
124STK390.44353142
125KSR10.43513734
126MAPKAPK50.43063206
127MAP3K50.42431788
128CSF1R0.42237865
129LIMK10.42056770
130PLK30.40692251
131PRKCE0.39773848
132MKNK10.39544639
133NEK60.39337177
134MAP3K130.37307177
135TGFBR20.37251965
136MAP3K110.36822593
137CSNK1G30.36213994
138PIK3CG0.35762429

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.44253275
2Protein export_Homo sapiens_hsa030603.16309845
3DNA replication_Homo sapiens_hsa030302.36894889
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.35560467
5RNA polymerase_Homo sapiens_hsa030202.32124845
6Graft-versus-host disease_Homo sapiens_hsa053322.14028639
7Allograft rejection_Homo sapiens_hsa053302.08622180
8Homologous recombination_Homo sapiens_hsa034402.05558084
9* Basal transcription factors_Homo sapiens_hsa030222.05161196
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95532423
11Ribosome_Homo sapiens_hsa030101.92709063
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85219079
13Rheumatoid arthritis_Homo sapiens_hsa053231.84729042
14Legionellosis_Homo sapiens_hsa051341.83237950
15RNA degradation_Homo sapiens_hsa030181.80783692
16Leishmaniasis_Homo sapiens_hsa051401.78970872
17Mismatch repair_Homo sapiens_hsa034301.77437101
18Non-homologous end-joining_Homo sapiens_hsa034501.76651231
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75513858
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.74331349
21Cell cycle_Homo sapiens_hsa041101.71119994
22Type I diabetes mellitus_Homo sapiens_hsa049401.65609266
23Pyrimidine metabolism_Homo sapiens_hsa002401.63080469
24Base excision repair_Homo sapiens_hsa034101.55920464
25Nucleotide excision repair_Homo sapiens_hsa034201.55700841
26Oxidative phosphorylation_Homo sapiens_hsa001901.49142800
27Spliceosome_Homo sapiens_hsa030401.48271871
28Fanconi anemia pathway_Homo sapiens_hsa034601.46710928
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45796859
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.42080844
31Asthma_Homo sapiens_hsa053101.34430859
32Herpes simplex infection_Homo sapiens_hsa051681.32315321
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30451925
34RNA transport_Homo sapiens_hsa030131.29487988
35Caffeine metabolism_Homo sapiens_hsa002321.27542777
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27504250
37Folate biosynthesis_Homo sapiens_hsa007901.24904721
38Measles_Homo sapiens_hsa051621.24006795
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20957794
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20485014
41Malaria_Homo sapiens_hsa051441.19369206
42Phagosome_Homo sapiens_hsa041451.19234596
43Pertussis_Homo sapiens_hsa051331.17686981
44* Epstein-Barr virus infection_Homo sapiens_hsa051691.14945781
45Autoimmune thyroid disease_Homo sapiens_hsa053201.13877057
46Hematopoietic cell lineage_Homo sapiens_hsa046401.13862102
47Shigellosis_Homo sapiens_hsa051311.11081456
48Huntingtons disease_Homo sapiens_hsa050161.09993047
49Other glycan degradation_Homo sapiens_hsa005111.09518644
50Primary immunodeficiency_Homo sapiens_hsa053401.08452170
51p53 signaling pathway_Homo sapiens_hsa041151.07444370
52Tuberculosis_Homo sapiens_hsa051521.07308915
53Antigen processing and presentation_Homo sapiens_hsa046121.02265769
54Parkinsons disease_Homo sapiens_hsa050120.99871874
55Influenza A_Homo sapiens_hsa051640.98726836
56Steroid biosynthesis_Homo sapiens_hsa001000.96896628
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96469602
58Apoptosis_Homo sapiens_hsa042100.95923697
59TNF signaling pathway_Homo sapiens_hsa046680.95803675
60Collecting duct acid secretion_Homo sapiens_hsa049660.95783535
61Sphingolipid metabolism_Homo sapiens_hsa006000.94530337
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94031780
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92689442
64Purine metabolism_Homo sapiens_hsa002300.91749874
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90729889
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88654061
67Osteoclast differentiation_Homo sapiens_hsa043800.87709465
68Regulation of autophagy_Homo sapiens_hsa041400.81587821
69Circadian rhythm_Homo sapiens_hsa047100.80723166
70Salmonella infection_Homo sapiens_hsa051320.78145347
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78145280
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77819428
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76014848
74Vibrio cholerae infection_Homo sapiens_hsa051100.74639872
75Hepatitis B_Homo sapiens_hsa051610.74299280
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.74190972
77Arachidonic acid metabolism_Homo sapiens_hsa005900.72680812
78Systemic lupus erythematosus_Homo sapiens_hsa053220.71482149
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71091520
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70965328
81Fatty acid elongation_Homo sapiens_hsa000620.69705450
82Alzheimers disease_Homo sapiens_hsa050100.68246001
83Chemokine signaling pathway_Homo sapiens_hsa040620.65391984
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.63850317
85Lysosome_Homo sapiens_hsa041420.63024848
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.62585341
87Toxoplasmosis_Homo sapiens_hsa051450.62148737
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60615487
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60152011
90African trypanosomiasis_Homo sapiens_hsa051430.59638678
91* Viral carcinogenesis_Homo sapiens_hsa052030.59145462
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58662621
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57687469
94Ether lipid metabolism_Homo sapiens_hsa005650.57319873
95N-Glycan biosynthesis_Homo sapiens_hsa005100.56305132
96Tryptophan metabolism_Homo sapiens_hsa003800.55457669
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54712764
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52665428
99Peroxisome_Homo sapiens_hsa041460.51653929
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51035777
101Glutathione metabolism_Homo sapiens_hsa004800.47916426
102Butanoate metabolism_Homo sapiens_hsa006500.47348182
103B cell receptor signaling pathway_Homo sapiens_hsa046620.44596604
104Linoleic acid metabolism_Homo sapiens_hsa005910.44177709
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42301815
106Pancreatic cancer_Homo sapiens_hsa052120.40399520
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39880662
108Chemical carcinogenesis_Homo sapiens_hsa052040.39431447
109HTLV-I infection_Homo sapiens_hsa051660.38281075
110Ovarian steroidogenesis_Homo sapiens_hsa049130.38156235
111One carbon pool by folate_Homo sapiens_hsa006700.36300849
112T cell receptor signaling pathway_Homo sapiens_hsa046600.35651603
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.35215525
114Sulfur metabolism_Homo sapiens_hsa009200.33101091
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32242735
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31614953
117mRNA surveillance pathway_Homo sapiens_hsa030150.28418670
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28097643
119Staphylococcus aureus infection_Homo sapiens_hsa051500.26584162

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