GTF2A1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.88856377
2piRNA metabolic process (GO:0034587)9.77051894
3reproduction (GO:0000003)9.75223066
4regulation of female gonad development (GO:2000194)9.31715701
5epithelial cilium movement (GO:0003351)9.31062309
6motile cilium assembly (GO:0044458)9.10460945
7spermatid development (GO:0007286)9.05366063
8male meiosis (GO:0007140)8.58837225
9regulation of cilium movement (GO:0003352)8.07282637
10cilium movement (GO:0003341)7.97386329
11synaptonemal complex organization (GO:0070193)7.78673230
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.69688433
13synaptonemal complex assembly (GO:0007130)7.63992951
14single fertilization (GO:0007338)7.63824196
15female gamete generation (GO:0007292)7.18624949
16sperm capacitation (GO:0048240)6.93080288
17oocyte development (GO:0048599)6.82214877
18fertilization (GO:0009566)6.57438468
19negative regulation of inclusion body assembly (GO:0090084)6.26266601
20spermatogenesis (GO:0007283)6.20652761
21male gamete generation (GO:0048232)6.18480410
22DNA methylation involved in gamete generation (GO:0043046)6.16071758
23glycine transport (GO:0015816)6.14363054
24regulation of histone H3-K9 methylation (GO:0051570)6.00261448
25retinal cone cell development (GO:0046549)5.82510678
26gamete generation (GO:0007276)5.77309955
27microtubule depolymerization (GO:0007019)5.73687714
28negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.62328269
29microtubule severing (GO:0051013)5.46729965
30organic cation transport (GO:0015695)5.43922830
31chromosome organization involved in meiosis (GO:0070192)5.36813184
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.34582242
33germ cell development (GO:0007281)5.31742831
34male meiosis I (GO:0007141)5.29305045
35positive regulation of histone H3-K4 methylation (GO:0051571)5.26184603
36regulation of steroid hormone secretion (GO:2000831)5.16630716
37negative regulation of reproductive process (GO:2000242)5.11501349
38regulation of inclusion body assembly (GO:0090083)5.10584544
39ventricular system development (GO:0021591)5.06061399
40regulation of cell maturation (GO:1903429)5.04967867
41cell recognition (GO:0008037)4.97303001
42meiotic nuclear division (GO:0007126)4.94495822
43mitotic chromosome condensation (GO:0007076)4.92730182
44regulation of retinoic acid receptor signaling pathway (GO:0048385)4.89231662
45calcium ion-dependent exocytosis (GO:0017156)4.85618384
46protein kinase C signaling (GO:0070528)4.74442226
47negative regulation of histone methylation (GO:0031061)4.72275012
48regulation of microtubule-based movement (GO:0060632)4.71758067
49oogenesis (GO:0048477)4.62592755
50spermatid nucleus differentiation (GO:0007289)4.57505191
51positive regulation of mitotic sister chromatid separation (GO:1901970)4.54950569
52positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.54950569
53positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.54950569
54multicellular organismal reproductive process (GO:0048609)4.52470879
55L-amino acid import (GO:0043092)4.46810337
56meiotic cell cycle (GO:0051321)4.44882879
57seminiferous tubule development (GO:0072520)4.42343467
58mitotic metaphase plate congression (GO:0007080)4.39578953
59positive regulation of gastrulation (GO:2000543)4.33540834
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.30689141
61positive regulation of uterine smooth muscle contraction (GO:0070474)4.28944882
62meiosis I (GO:0007127)4.26657264
63attachment of spindle microtubules to kinetochore (GO:0008608)4.23566430
64regulation of meiosis (GO:0040020)4.20623936
65chromosome condensation (GO:0030261)4.20432569
66protein localization to kinetochore (GO:0034501)4.19961159
67positive regulation of chromosome segregation (GO:0051984)4.17997390
68protein polyglutamylation (GO:0018095)4.14398988
69paraxial mesoderm development (GO:0048339)4.05745017
70positive regulation of humoral immune response (GO:0002922)4.04728805
71DNA packaging (GO:0006323)3.95053181
72monoubiquitinated protein deubiquitination (GO:0035520)3.94626234
73CENP-A containing nucleosome assembly (GO:0034080)3.90442353
74glycerol ether metabolic process (GO:0006662)3.88646786
75left/right pattern formation (GO:0060972)3.87163869
76establishment of chromosome localization (GO:0051303)3.84448360
77translesion synthesis (GO:0019985)3.84185704
78labyrinthine layer development (GO:0060711)3.80551969
79positive regulation of reproductive process (GO:2000243)3.76587682
80phosphorelay signal transduction system (GO:0000160)3.71208527
81protein localization to chromosome (GO:0034502)3.68398176
82gene silencing by RNA (GO:0031047)3.68234490
83protein localization to cilium (GO:0061512)3.68115325
84histone H3-K9 demethylation (GO:0033169)3.64938005
85regulation of meiotic cell cycle (GO:0051445)3.63869252
86primitive streak formation (GO:0090009)3.63087263
87multicellular organismal development (GO:0007275)3.59997815
88DNA alkylation (GO:0006305)3.59119081
89DNA methylation (GO:0006306)3.59119081
90ether metabolic process (GO:0018904)3.58409620
91chaperone-mediated protein complex assembly (GO:0051131)3.56700131
92metaphase plate congression (GO:0051310)3.53516257
93genitalia morphogenesis (GO:0035112)3.52354363
94regulation of cytokine production involved in inflammatory response (GO:1900015)3.51610757
95chromatin remodeling at centromere (GO:0031055)3.51508708
96positive regulation of histone methylation (GO:0031062)3.48142553
97positive regulation of meiosis (GO:0045836)3.45345666
98relaxation of smooth muscle (GO:0044557)3.42914480
99DNA damage induced protein phosphorylation (GO:0006975)3.42223816
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.42010630
101somite rostral/caudal axis specification (GO:0032525)3.41980396
102single strand break repair (GO:0000012)3.39172504
103meiotic cell cycle process (GO:1903046)3.36232541
104nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.35583739
105negative regulation of organelle assembly (GO:1902116)3.31836166
106regulation of spindle checkpoint (GO:0090231)3.29073893
107synapsis (GO:0007129)3.26828527
108regulation of uterine smooth muscle contraction (GO:0070472)3.25896579
109intraciliary transport (GO:0042073)3.25601307
110positive regulation of meiotic cell cycle (GO:0051446)3.24336635
111regulation of reproductive process (GO:2000241)3.23996686
112regulation of female receptivity (GO:0045924)3.22718811
113regulation of steroid hormone biosynthetic process (GO:0090030)3.22015796
114negative regulation of execution phase of apoptosis (GO:1900118)3.21524960
115regulation of histone H3-K4 methylation (GO:0051569)3.17454431
116regulation of spindle organization (GO:0090224)3.16415417
117microtubule polymerization or depolymerization (GO:0031109)3.15561168
118negative regulation of cAMP-mediated signaling (GO:0043951)3.13129927
119protein K11-linked deubiquitination (GO:0035871)3.11426730
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10625664
121carnitine transport (GO:0015879)3.09034850
122amino-acid betaine transport (GO:0015838)3.09034850
123DNA replication-dependent nucleosome assembly (GO:0006335)3.08332065
124DNA replication-dependent nucleosome organization (GO:0034723)3.08332065
125sister chromatid cohesion (GO:0007062)3.07397834
126cellular response to pH (GO:0071467)3.07037498
127mitotic sister chromatid cohesion (GO:0007064)3.07027582
128aggressive behavior (GO:0002118)3.05985586
129response to acidic pH (GO:0010447)3.05825074
130cilium organization (GO:0044782)3.05377442
131regulation of histone methylation (GO:0031060)3.02580621
132microtubule-based movement (GO:0007018)3.01475037
133carnitine transmembrane transport (GO:1902603)2.98111072
134regulation of centriole replication (GO:0046599)2.95939029
135cilium assembly (GO:0042384)2.92734135
136cilium morphogenesis (GO:0060271)2.92051848
137centriole assembly (GO:0098534)2.89528828
138regulation of acrosome reaction (GO:0060046)2.88515342
139lactate metabolic process (GO:0006089)2.83912225
140centriole replication (GO:0007099)2.83819310
141cellular component assembly involved in morphogenesis (GO:0010927)2.83428371
142alditol metabolic process (GO:0019400)2.79874784
143axoneme assembly (GO:0035082)2.79825509
144polyol catabolic process (GO:0046174)2.79039826
145protein refolding (GO:0042026)2.77319737
146gene silencing (GO:0016458)2.77194053
147nucleus organization (GO:0006997)2.74560147
148peptidyl-glutamic acid modification (GO:0018200)2.68813276
149glycolytic process (GO:0006096)2.67568128
150sexual reproduction (GO:0019953)2.66300805
151nucleoside diphosphate phosphorylation (GO:0006165)2.66052163
152protein localization to chromosome, centromeric region (GO:0071459)2.65311260
153nuclear pore complex assembly (GO:0051292)2.61501528
154regulation of meiosis I (GO:0060631)2.58920493
155histone exchange (GO:0043486)2.58221772
156interferon-gamma secretion (GO:0072643)2.57664781
157regulation of cilium assembly (GO:1902017)2.51660684
158fusion of sperm to egg plasma membrane (GO:0007342)12.9813385
159sperm motility (GO:0030317)12.1784732
160cell wall macromolecule metabolic process (GO:0044036)11.9741678
161cell wall macromolecule catabolic process (GO:0016998)11.9741678
162multicellular organism reproduction (GO:0032504)11.7777228
163cilium or flagellum-dependent cell motility (GO:0001539)11.7171171
164acrosome assembly (GO:0001675)11.6035003
165sperm-egg recognition (GO:0035036)11.5427048
166regulation of DNA methylation (GO:0044030)10.5870146
167acrosome reaction (GO:0007340)10.5285182
168binding of sperm to zona pellucida (GO:0007339)10.5077004
169cell-cell recognition (GO:0009988)10.3151179
170axonemal dynein complex assembly (GO:0070286)10.0393370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.94776452
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.63288965
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.61349994
4EZH2_22144423_ChIP-Seq_EOC_Human4.55004099
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.91832571
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.53626348
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.93586965
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.93586965
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.93586965
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.67636141
11E2F7_22180533_ChIP-Seq_HELA_Human2.63899016
12GBX2_23144817_ChIP-Seq_PC3_Human2.58416466
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51388232
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.34773046
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30572624
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28731160
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28662409
18VDR_22108803_ChIP-Seq_LS180_Human2.22794716
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.18533884
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.17525609
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.14252916
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12879172
23GATA1_26923725_Chip-Seq_HPCs_Mouse2.10220726
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94129621
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.89525901
26ZNF274_21170338_ChIP-Seq_K562_Hela1.89150097
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87492081
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86295250
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.86280752
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.84202730
31* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.82193233
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.80443088
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.73440940
34STAT1_17558387_ChIP-Seq_HELA_Human1.68222532
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.67514394
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63032153
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.60924138
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60493425
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60260100
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58927437
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.57766944
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.52437758
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.52364332
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51135304
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51091637
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50929853
47KDM2B_26808549_Chip-Seq_REH_Human1.49775875
48TAL1_26923725_Chip-Seq_HPCs_Mouse1.49401104
49GATA3_21867929_ChIP-Seq_CD8_Mouse1.45391322
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44375971
51TCF4_23295773_ChIP-Seq_U87_Human1.41235190
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40996355
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.39940044
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39643797
55SOX2_22085726_ChIP-Seq_NPCs_Mouse1.38982974
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.38646916
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37789988
58CBP_20019798_ChIP-Seq_JUKART_Human1.37789988
59SMAD4_21799915_ChIP-Seq_A2780_Human1.37358985
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.36791963
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35462748
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.32952616
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.32811300
64AR_25329375_ChIP-Seq_VCAP_Human1.32460241
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31272072
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.30072273
67* GATA3_21867929_ChIP-Seq_TH1_Mouse1.29940001
68RUNX1_26923725_Chip-Seq_HPCs_Mouse1.29680940
69P300_19829295_ChIP-Seq_ESCs_Human1.29632751
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29450883
71RNF2_27304074_Chip-Seq_NSC_Mouse1.29204288
72LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.24542674
73NANOG_20526341_ChIP-Seq_ESCs_Human1.23158817
74STAT3_23295773_ChIP-Seq_U87_Human1.22182080
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.22107870
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.21879986
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21490837
78FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21334937
79GF1_26923725_Chip-Seq_HPCs_Mouse1.20633842
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20577388
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20107333
82SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19753115
83OCT4_18555785_Chip-Seq_ESCs_Mouse1.18979595
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.18703911
85P53_21459846_ChIP-Seq_SAOS-2_Human1.16462166
86CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16398417
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15022895
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14956461
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.14615917
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14108007
91IRF1_19129219_ChIP-ChIP_H3396_Human1.14100754
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12790465
93RUNX2_22187159_ChIP-Seq_PCA_Human1.12731029
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12440064
95E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12068893
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11521703
97REST_21632747_ChIP-Seq_MESCs_Mouse1.11512332
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.10923568
99P53_22387025_ChIP-Seq_ESCs_Mouse1.09720105
100HTT_18923047_ChIP-ChIP_STHdh_Human1.09633957
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09609859
102ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08763956
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08696203
104SPI1_26923725_Chip-Seq_HPCs_Mouse1.08431056
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07670050
106P300_18555785_Chip-Seq_ESCs_Mouse1.06823328
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06776182
108ESET_19884257_ChIP-Seq_ESCs_Mouse1.06774691
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.06693917
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06548405
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06548405
112CBP_21632823_ChIP-Seq_H3396_Human1.04071119
113OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04036873
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.02180387
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01502496
116ERG_20517297_ChIP-Seq_VCAP_Human1.00550145
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00340619
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99941629
119SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99905711
120FOXH1_21741376_ChIP-Seq_EPCs_Human0.99866548
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99736703
122SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98892135
123GF1B_26923725_Chip-Seq_HPCs_Mouse0.98611790
124CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98544746
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98126833
126BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97452750
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97321543
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97144952
129CTCF_18555785_Chip-Seq_ESCs_Mouse0.96466624
130SALL4_22934838_ChIP-ChIP_CD34+_Human0.96459886
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96294422
132LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96032331
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95802638
134POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95676989
135FUS_26573619_Chip-Seq_HEK293_Human0.95102113
136SOX2_18555785_Chip-Seq_ESCs_Mouse0.93982792
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93676654
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93605109
139PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93544477
140NANOG_19829295_ChIP-Seq_ESCs_Human0.93280477
141SOX2_19829295_ChIP-Seq_ESCs_Human0.93280477
142BCAT_22108803_ChIP-Seq_LS180_Human0.92753158
143CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92707955
144RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91920083
145AR_21909140_ChIP-Seq_LNCAP_Human0.91099566
146PU1_27457419_Chip-Seq_LIVER_Mouse0.90422192
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90391156
148CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90320616
149AHR_22903824_ChIP-Seq_MCF-7_Human0.89862250
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89718806
151NFYB_21822215_ChIP-Seq_K562_Human0.89347027
152EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89121761
153SALL1_21062744_ChIP-ChIP_HESCs_Human0.89090617
154RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89033275
155TP53_16413492_ChIP-PET_HCT116_Human0.88206495
156GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88021770
157NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87705908
158SMAD3_21741376_ChIP-Seq_EPCs_Human0.87603485
159NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87405828
160RARA_24833708_ChIP-Seq_LIVER_Mouse0.87171028
161ER_23166858_ChIP-Seq_MCF-7_Human0.87112407
162FLI1_21867929_ChIP-Seq_CD8_Mouse0.86684698
163CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84696630
164TP53_22573176_ChIP-Seq_HFKS_Human0.84202444
165ARNT_22903824_ChIP-Seq_MCF-7_Human0.84138106
166SMRT_27268052_Chip-Seq_Bcells_Human0.83499409
167CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82999443
168EZH2_27304074_Chip-Seq_ESCs_Mouse0.82884680
169AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80630122
170* EWS_26573619_Chip-Seq_HEK293_Human0.77434955
171SOX2_21211035_ChIP-Seq_LN229_Gbm0.77079627
172PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76365549
173DROSHA_22980978_ChIP-Seq_HELA_Human0.74216805
174GATA3_26560356_Chip-Seq_TH1_Human0.74079614
175TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.73509690
176ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73485116
177CDX2_22108803_ChIP-Seq_LS180_Human0.71881281
178KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70137918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.91655248
2MP0001929_abnormal_gametogenesis5.78964968
3MP0008877_abnormal_DNA_methylation5.25700004
4MP0008789_abnormal_olfactory_epithelium3.89186601
5MP0002210_abnormal_sex_determination3.86537857
6MP0006292_abnormal_olfactory_placode3.79904379
7MP0003890_abnormal_embryonic-extraembry3.73113422
8MP0002653_abnormal_ependyma_morphology3.49071487
9MP0005394_taste/olfaction_phenotype3.47744865
10MP0005499_abnormal_olfactory_system3.47744865
11MP0002161_abnormal_fertility/fecundity3.42373466
12MP0001145_abnormal_male_reproductive3.19263652
13MP0002138_abnormal_hepatobiliary_system3.13340050
14MP0005360_urolithiasis3.03905678
15MP0000653_abnormal_sex_gland2.98260619
16MP0010234_abnormal_vibrissa_follicle2.70709771
17MP0002139_abnormal_hepatobiliary_system2.51480134
18MP0010030_abnormal_orbit_morphology2.40172674
19MP0003646_muscle_fatigue2.25237801
20MP0003136_yellow_coat_color2.17573592
21MP0005670_abnormal_white_adipose2.09311584
22MP0005623_abnormal_meninges_morphology2.07739250
23MP0005410_abnormal_fertilization15.0381455
24MP0000566_synostosis1.71447249
25MP0002160_abnormal_reproductive_system1.70987243
26MP0003183_abnormal_peptide_metabolism1.56749075
27MP0002282_abnormal_trachea_morphology1.51885470
28MP0008058_abnormal_DNA_repair1.43024499
29MP0010094_abnormal_chromosome_stability1.39670818
30MP0010368_abnormal_lymphatic_system1.31828550
31MP0004233_abnormal_muscle_weight1.30229467
32MP0003252_abnormal_bile_duct1.28802199
33MP0009046_muscle_twitch1.28448854
34MP0004142_abnormal_muscle_tone1.21052650
35MP0000631_abnormal_neuroendocrine_gland1.20532377
36MP0001986_abnormal_taste_sensitivity1.20189864
37MP0008057_abnormal_DNA_replication1.20065827
38MP0001984_abnormal_olfaction1.11437131
39MP0002233_abnormal_nose_morphology1.07621967
40MP0010678_abnormal_skin_adnexa1.06010615
41MP0005085_abnormal_gallbladder_physiolo1.05125590
42MP0005389_reproductive_system_phenotype1.04650848
43MP0006276_abnormal_autonomic_nervous1.03638585
44MP0003699_abnormal_female_reproductive1.02625488
45MP0005647_abnormal_sex_gland1.02243968
46MP0000762_abnormal_tongue_morphology1.00753095
47MP0003718_maternal_effect0.98554363
48MP0003119_abnormal_digestive_system0.98333915
49MP0002272_abnormal_nervous_system0.96215780
50MP0001765_abnormal_ion_homeostasis0.95091931
51MP0009840_abnormal_foam_cell0.94769174
52MP0001119_abnormal_female_reproductive0.93524660
53MP0004381_abnormal_hair_follicle0.87588632
54MP0003111_abnormal_nucleus_morphology0.86779255
55MP0005171_absent_coat_pigmentation0.84231806
56MP0002837_dystrophic_cardiac_calcinosis0.83509955
57MP0003011_delayed_dark_adaptation0.82656430
58MP0003121_genomic_imprinting0.82046223
59MP0003950_abnormal_plasma_membrane0.79894674
60MP0005075_abnormal_melanosome_morpholog0.79475849
61MP0002102_abnormal_ear_morphology0.78437605
62MP0002234_abnormal_pharynx_morphology0.78320876
63MP0003195_calcinosis0.75569863
64MP0001664_abnormal_digestion0.69579852
65MP0003941_abnormal_skin_development0.68326715
66MP0008995_early_reproductive_senescence0.68072002
67MP0000049_abnormal_middle_ear0.67689203
68MP0001963_abnormal_hearing_physiology0.66227360
69MP0005503_abnormal_tendon_morphology0.64758903
70MP0008004_abnormal_stomach_pH0.64204051
71MP0008007_abnormal_cellular_replicative0.63366593
72MP0000678_abnormal_parathyroid_gland0.61562719
73MP0000015_abnormal_ear_pigmentation0.61524099
74MP0000350_abnormal_cell_proliferation0.61269277
75MP0001666_abnormal_nutrient_absorption0.58175532
76MP0000569_abnormal_digit_pigmentation0.57843131
77MP0002735_abnormal_chemical_nociception0.57439801
78MP0003786_premature_aging0.57314152
79MP0002127_abnormal_cardiovascular_syste0.56021726
80MP0003077_abnormal_cell_cycle0.55449925
81MP0002796_impaired_skin_barrier0.55189719
82MP0002168_other_aberrant_phenotype0.54482028
83MP0001502_abnormal_circadian_rhythm0.52635522
84MP0002295_abnormal_pulmonary_circulatio0.51803468
85MP0002928_abnormal_bile_duct0.50929513
86MP0003787_abnormal_imprinting0.50737261
87MP0009379_abnormal_foot_pigmentation0.49719855
88MP0000026_abnormal_inner_ear0.49579148
89MP0003115_abnormal_respiratory_system0.48237180
90MP0003868_abnormal_feces_composition0.48199779
91MP0002269_muscular_atrophy0.47331138
92MP0000358_abnormal_cell_content/0.46964355
93MP0005501_abnormal_skin_physiology0.46614998
94MP0000383_abnormal_hair_follicle0.46120372
95MP0001730_embryonic_growth_arrest0.44330644
96MP0005636_abnormal_mineral_homeostasis0.44270238
97MP0006138_congestive_heart_failure0.44242506
98MP0004036_abnormal_muscle_relaxation0.43838856
99MP0005174_abnormal_tail_pigmentation0.43053253
100MP0001324_abnormal_eye_pigmentation0.42475277
101MP0005395_other_phenotype0.42261230
102MP0002638_abnormal_pupillary_reflex0.42182600
103MP0002095_abnormal_skin_pigmentation0.40335716
104MP0005253_abnormal_eye_physiology0.40176411
105MP0001486_abnormal_startle_reflex0.39996395
106MP0003878_abnormal_ear_physiology0.38948001
107MP0005377_hearing/vestibular/ear_phenot0.38948001
108MP0001293_anophthalmia0.38824722
109MP0003329_amyloid_beta_deposits0.38728442
110MP0005451_abnormal_body_composition0.36125299
111MP0001545_abnormal_hematopoietic_system0.35738715
112MP0005397_hematopoietic_system_phenotyp0.35738715
113MP0010307_abnormal_tumor_latency0.35703745
114MP0006072_abnormal_retinal_apoptosis0.35640203
115MP0001919_abnormal_reproductive_system0.34631434
116MP0005551_abnormal_eye_electrophysiolog0.34391517
117MP0003861_abnormal_nervous_system0.33287044
118MP0005391_vision/eye_phenotype0.31047536
119MP0003942_abnormal_urinary_system0.30692226
120MP0006036_abnormal_mitochondrial_physio0.29732788
121MP0002736_abnormal_nociception_after0.29691872
122MP0002084_abnormal_developmental_patter0.29317342
123MP0005666_abnormal_adipose_tissue0.29173209
124MP0000313_abnormal_cell_death0.27542859
125MP0003693_abnormal_embryo_hatching0.27147129
126MP0000427_abnormal_hair_cycle0.26706872
127MP0004133_heterotaxia0.26420781
128MP0004808_abnormal_hematopoietic_stem0.26286268
129MP0009115_abnormal_fat_cell0.26248719
130MP0002152_abnormal_brain_morphology0.25596866
131MP0001764_abnormal_homeostasis0.25537958
132MP0005646_abnormal_pituitary_gland0.25507106
133MP0002971_abnormal_brown_adipose0.25357365
134MP0004957_abnormal_blastocyst_morpholog0.24151466
135MP0009278_abnormal_bone_marrow0.24030593
136MP0004134_abnormal_chest_morphology0.23701641
137MP0002085_abnormal_embryonic_tissue0.23480151
138MP0005380_embryogenesis_phenotype0.22987826
139MP0001672_abnormal_embryogenesis/_devel0.22987826
140MP0001697_abnormal_embryo_size0.22771662
141MP0008932_abnormal_embryonic_tissue0.22187246
142MP0002169_no_abnormal_phenotype0.18597125
143MP0002873_normal_phenotype0.18402542
144MP0003879_abnormal_hair_cell0.18165559
145MP0003315_abnormal_perineum_morphology0.17296191
146MP0004811_abnormal_neuron_physiology0.17187828
147MP0000432_abnormal_head_morphology0.16623649
148MP0009697_abnormal_copulation0.16495680
149MP0000534_abnormal_ureter_morphology0.16440064
150MP0004019_abnormal_vitamin_homeostasis0.16378804
151MP0003631_nervous_system_phenotype0.15849070
152MP0003633_abnormal_nervous_system0.15604966
153MP0000001_mammalian_phenotype0.15028204
154MP0002092_abnormal_eye_morphology0.14433289
155MP0002229_neurodegeneration0.13444989
156MP0005195_abnormal_posterior_eye0.13375575
157MP0002080_prenatal_lethality0.13286456

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.42825062
2Abnormal respiratory motile cilium morphology (HP:0005938)8.55367041
3Abnormal respiratory epithelium morphology (HP:0012253)8.55367041
4Rhinitis (HP:0012384)7.81019398
5Chronic bronchitis (HP:0004469)7.44793662
6Abnormal ciliary motility (HP:0012262)7.44267951
7Infertility (HP:0000789)6.95397730
8Nasal polyposis (HP:0100582)6.25969533
9Abnormality of the nasal mucosa (HP:0000433)5.10393950
10Osteomalacia (HP:0002749)5.03241879
11Abnormality of abdominal situs (HP:0011620)4.99874563
12Abdominal situs inversus (HP:0003363)4.99874563
13Male infertility (HP:0003251)4.80835237
14Bronchiectasis (HP:0002110)4.76333055
15Bronchitis (HP:0012387)4.63159070
16Hypophosphatemic rickets (HP:0004912)4.56597421
17Facial hemangioma (HP:0000329)4.49284032
18Nephronophthisis (HP:0000090)4.42856341
19Lip pit (HP:0100267)4.18748849
20Hypoplasia of the fovea (HP:0007750)4.16712103
21Aplasia/Hypoplasia of the fovea (HP:0008060)4.16712103
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.13430514
23Oligodactyly (hands) (HP:0001180)4.10077203
24Malnutrition (HP:0004395)3.94017795
25Papillary thyroid carcinoma (HP:0002895)3.83164469
26Premature ovarian failure (HP:0008209)3.80018584
27Anterior segment dysgenesis (HP:0007700)3.76233733
28Septo-optic dysplasia (HP:0100842)3.69905865
29Conjunctival telangiectasia (HP:0000524)3.68259072
30Abnormality of the fovea (HP:0000493)3.67703596
31Short tibia (HP:0005736)3.42223200
32Abnormal spermatogenesis (HP:0008669)3.40458606
33Chromosomal breakage induced by crosslinking agents (HP:0003221)3.37572907
34Chromsome breakage (HP:0040012)3.35908248
35Abnormality of the renal medulla (HP:0100957)3.35657554
36Recurrent otitis media (HP:0000403)3.31362921
37Aplasia/Hypoplasia of the tibia (HP:0005772)3.25136171
38Absent septum pellucidum (HP:0001331)3.24081256
39Recurrent sinusitis (HP:0011108)3.17006528
40Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.96974274
41Abnormality of midbrain morphology (HP:0002418)2.93052084
42Molar tooth sign on MRI (HP:0002419)2.93052084
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.92115188
44Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.89595392
45Oligodactyly (HP:0012165)2.86922068
46Medial flaring of the eyebrow (HP:0010747)2.86569210
47Generalized aminoaciduria (HP:0002909)2.77209821
48Abnormality of the septum pellucidum (HP:0007375)2.75899394
49Recurrent bronchitis (HP:0002837)2.75402675
50Abnormality of the labia minora (HP:0012880)2.74654023
51Capillary hemangiomas (HP:0005306)2.71667233
52Muscle stiffness (HP:0003552)2.67673406
53Wrist flexion contracture (HP:0001239)2.65881795
54Aplasia/Hypoplasia of the macula (HP:0008059)2.63761910
55Tubulointerstitial nephritis (HP:0001970)2.61196838
56Tubular atrophy (HP:0000092)2.56471829
57Impulsivity (HP:0100710)2.52806610
58Skin pits (HP:0100276)2.48262306
59Sensory axonal neuropathy (HP:0003390)2.47693539
60Proximal tubulopathy (HP:0000114)2.47032834
61Truncal obesity (HP:0001956)2.46484950
62Fair hair (HP:0002286)2.43616481
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.43485654
64Enlarged penis (HP:0000040)2.41207470
65Gonadotropin excess (HP:0000837)2.40718502
66Metaphyseal irregularity (HP:0003025)2.40651340
67Urethral obstruction (HP:0000796)2.40192146
68Azoospermia (HP:0000027)2.39356613
69Aplasia/Hypoplasia affecting the retina (HP:0008061)2.39351845
70Tubulointerstitial abnormality (HP:0001969)2.35151210
71Spinal cord compression (HP:0002176)2.34599649
72Abnormality of the lower motor neuron (HP:0002366)2.31588512
73Loss of speech (HP:0002371)2.29282445
74Aplastic anemia (HP:0001915)2.26883705
75Congenital sensorineural hearing impairment (HP:0008527)2.26389141
76Myokymia (HP:0002411)2.23220497
77Abnormality of the phalanges of the hallux (HP:0010057)2.20561107
78Hypokinesia (HP:0002375)2.19896852
79Stillbirth (HP:0003826)2.18524333
80Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16313694
81Intrahepatic cholestasis (HP:0001406)2.15293116
82Cholecystitis (HP:0001082)2.13610667
83Abnormal gallbladder physiology (HP:0012438)2.13610667
84Striae distensae (HP:0001065)2.12388231
85Postaxial foot polydactyly (HP:0001830)2.09784861
86Abnormal lung lobation (HP:0002101)2.09683766
87Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08751604
88Hydroureter (HP:0000072)2.05521433
89Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05125499
90Diminished motivation (HP:0000745)2.04578683
91Fibular hypoplasia (HP:0003038)2.04361789
92Thyroid carcinoma (HP:0002890)2.01683836
93Apathy (HP:0000741)2.00614958
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8274023
95Dynein arm defect of respiratory motile cilia (HP:0012255)12.3121230
96Absent/shortened dynein arms (HP:0200106)12.3121230
97Cranial hyperostosis (HP:0004437)1.99288182
98Tubulointerstitial fibrosis (HP:0005576)1.98410210
99Chronic hepatic failure (HP:0100626)1.97301664
100Congenital hepatic fibrosis (HP:0002612)1.96839435
101Dysdiadochokinesis (HP:0002075)1.93755877
102Lower limb hyperreflexia (HP:0002395)1.92844712
103Bundle branch block (HP:0011710)1.92291682
104Maternal diabetes (HP:0009800)1.91725143
105Duodenal stenosis (HP:0100867)1.91634744
106Small intestinal stenosis (HP:0012848)1.91634744
107Ankle contracture (HP:0006466)1.90767447
108Amyotrophic lateral sclerosis (HP:0007354)1.89125124
109Rickets (HP:0002748)1.85985093
110Aplasia of the musculature (HP:0100854)1.85967169
111Anhidrosis (HP:0000970)1.85618143
112Optic nerve hypoplasia (HP:0000609)1.85423518
113Stage 5 chronic kidney disease (HP:0003774)1.84889341
114Posterior subcapsular cataract (HP:0007787)1.83766148
115Nausea (HP:0002018)1.82711419
116Short ribs (HP:0000773)1.81303001
117Subcapsular cataract (HP:0000523)1.81077900
118Periauricular skin pits (HP:0100277)1.80561218
119Preauricular pit (HP:0004467)1.80561218
120Abnormal drinking behavior (HP:0030082)1.80143650
121Polydipsia (HP:0001959)1.80143650
122Congenital primary aphakia (HP:0007707)1.77384832
123Gait imbalance (HP:0002141)1.76168111
124Microglossia (HP:0000171)1.73811905
125Facial cleft (HP:0002006)1.73251894
126Abnormality of the renal cortex (HP:0011035)1.72490451
127Pancreatic fibrosis (HP:0100732)1.70988949
128Oculomotor apraxia (HP:0000657)1.70912238
129Supernumerary spleens (HP:0009799)1.68945617
130Postaxial hand polydactyly (HP:0001162)1.68876857
131Renal dysplasia (HP:0000110)1.68307096
132Chronic sinusitis (HP:0011109)1.67873419
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67469810
134Absent epiphyses (HP:0010577)1.67469810
135Abnormality of the dental root (HP:0006486)1.63179139
136Taurodontia (HP:0000679)1.63179139
137Abnormality of permanent molar morphology (HP:0011071)1.63179139
138Impaired proprioception (HP:0010831)1.60771583
139Aplasia/Hypoplasia of the lens (HP:0008063)1.57756788
140Bile duct proliferation (HP:0001408)1.55314389
141Abnormal biliary tract physiology (HP:0012439)1.55314389
142Abnormality of dentin (HP:0010299)1.53707722
143Heterotopia (HP:0002282)1.53582456
144Abnormality of molar (HP:0011077)1.52074745
145Abnormality of molar morphology (HP:0011070)1.52074745
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.51526534
147Cystic liver disease (HP:0006706)1.51237316
148Nephrogenic diabetes insipidus (HP:0009806)1.51040643
149Median cleft lip (HP:0000161)1.51002292
150Abnormality of renal excretion (HP:0011036)1.50804524
151Spastic tetraparesis (HP:0001285)1.50795814
152Dyschromatopsia (HP:0007641)1.49818105
153Absent frontal sinuses (HP:0002688)1.49774256
154J-shaped sella turcica (HP:0002680)1.49251909
155Abnormality of the dental pulp (HP:0006479)1.47589823
156Decreased central vision (HP:0007663)1.45786398
157Short thorax (HP:0010306)1.41087931
158Bell-shaped thorax (HP:0001591)1.40673612
159Deformed sella turcica (HP:0002681)1.40081158
160Genital tract atresia (HP:0001827)1.40017484
161Aplasia/Hypoplasia of the fibula (HP:0006492)1.38541879
162Poor coordination (HP:0002370)1.36718908
163Vaginal atresia (HP:0000148)1.34941030
164Abnormality of ocular smooth pursuit (HP:0000617)1.33886967
165Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.32142346
166Cerebellar dysplasia (HP:0007033)1.31693703
167True hermaphroditism (HP:0010459)1.29529175
168Degeneration of anterior horn cells (HP:0002398)1.29255950
169Abnormality of the anterior horn cell (HP:0006802)1.29255950
170Upper motor neuron abnormality (HP:0002127)1.28315231
171Occipital encephalocele (HP:0002085)1.28100059
172Abnormality of saccadic eye movements (HP:0000570)1.27637050
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.27445167
174Short femoral neck (HP:0100864)1.26766815
175Tongue fasciculations (HP:0001308)1.24714007
176Choroideremia (HP:0001139)1.24444972
177Nephroblastoma (Wilms tumor) (HP:0002667)1.22832563
178Sloping forehead (HP:0000340)1.22770994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.50031460
2PDK48.50031460
3MAP3K136.06063142
4ARAF5.85242575
5PDK25.44163778
6TESK15.07517085
7PRKD34.60784382
8ICK3.42696792
9STK243.14716177
10MET2.83997671
11KSR22.42099914
12PTK2B2.40502216
13WNK42.29220171
14STK392.24054800
15CDK91.99679099
16PNCK1.89814259
17NEK21.88119878
18EIF2AK31.85375812
19RAF11.76533496
20STK381.75664701
21ZAK1.74650860
22PRKCI1.43756086
23TTK1.40487131
24KSR11.31753390
25TNIK1.29485219
26TRIM281.28260358
27ACVR1B1.14499319
28CDK71.13586546
29BMPR21.09295526
30STK38L1.04388303
31DYRK1B1.03679160
32CDK191.02277600
33PDK10.99906382
34STK30.97967475
35PIM10.97153290
36TYRO30.96545203
37PLK40.96258456
38NEK90.94527870
39CDC70.91716759
40MOS0.87635371
41CHEK20.85460784
42CCNB10.84634170
43TIE10.81707719
44MAP3K80.81285686
45DYRK30.81136904
46PTK20.79825630
47MARK30.79301854
48MAPK150.78446974
49TNK20.77815926
50WNK10.77133694
51PASK0.73849675
52DMPK0.71998965
53NUAK10.71968959
54PINK10.69109042
55EEF2K0.62649496
56WEE10.60319897
57PLK30.59622476
58TGFBR10.57001524
59MAP3K60.56888828
60NTRK30.53702373
61TESK20.53544899
62BRAF0.53053058
63MST40.52894920
64IRAK10.52893404
65MUSK0.51573292
66CHEK10.50665582
67PDPK10.50337781
68PLK10.49934323
69LMTK20.49926712
70STK100.47865859
71PKN10.47622613
72MAP3K40.46035599
73ATR0.45648903
74TLK10.44293490
75MAP2K70.43304609
76NLK0.42704310
77BRSK20.41993953
78CSF1R0.39942022
79MAPK130.39696790
80ATM0.39235823
81MAPKAPK30.39060429
82CSNK1G10.38597690
83OXSR10.38314301
84RIPK40.37787606
85LATS10.37635624
86TAOK30.36777960
87VRK10.34746188
88NTRK20.33786937
89PAK10.33016137
90MAPKAPK50.31098772
91BMPR1B0.30648447
92MAP2K10.29736166
93PIK3CG0.29727847
94LRRK20.28932963
95KDR0.27677699
96CDK50.26912791
97BUB10.26633901
98PRKAA10.25588393
99MAP2K60.22612808
100CAMK1G0.22428737
101NEK60.21966061
102TRPM70.21060710
103BRSK10.21054137
104PRKCG0.20886119
105LATS20.20227018
106CSNK1E0.19960773
107CSNK1A1L0.19700702
108TAOK10.19660631
109PRKACA0.19335763
110MTOR0.19229341
111MAPK10.19167313
112CDK80.18743656
113MAP3K10.18287303
114MARK20.16827320
115AURKA0.16358974
116CDK120.13554633
117IRAK20.11716794
118RPS6KB10.10452398
119CDK10.10256256
120PRKCQ0.09621448
121CAMKK10.08684689
122MELK0.08414814
123ERBB40.07840167
124CDK20.07814702
125PAK20.07740690
126AURKB0.06315169
127MAP3K90.05889596
128GSK3B0.05830501
129CDK30.05296622
130STK110.04940019
131CDK150.04771176
132PDGFRB0.04767603
133PRKCZ0.04388904
134RPS6KA10.04152996
135PRKG10.04057367
136CSNK1D0.03846568
137CAMK2A0.03838473
138MAP3K50.03694464
139WNK30.03546599
140PAK60.03507219
141CDK180.02234497
142ZAP700.01753481
143MAPK80.01316845
144CDK40.01126657
145CDK11A0.00550762
146PRKDC0.00074626
147PRKCA-0.0243512
148EGFR-0.0222850
149PRKACB-0.0205899

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.55676245
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.15989720
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.90806526
4Pyruvate metabolism_Homo sapiens_hsa006203.74649607
5Mismatch repair_Homo sapiens_hsa034303.67714935
6Fatty acid biosynthesis_Homo sapiens_hsa000613.58581207
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.17819574
8Linoleic acid metabolism_Homo sapiens_hsa005913.10971284
9Propanoate metabolism_Homo sapiens_hsa006402.88335490
10Caffeine metabolism_Homo sapiens_hsa002322.76961628
11Glucagon signaling pathway_Homo sapiens_hsa049222.71206004
12Fanconi anemia pathway_Homo sapiens_hsa034602.65334361
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.59933053
14Oocyte meiosis_Homo sapiens_hsa041142.46839587
15Pentose phosphate pathway_Homo sapiens_hsa000302.37102966
16* Basal transcription factors_Homo sapiens_hsa030222.26340718
17Dorso-ventral axis formation_Homo sapiens_hsa043202.19712524
18Nucleotide excision repair_Homo sapiens_hsa034202.19470670
19Selenocompound metabolism_Homo sapiens_hsa004502.11243949
20DNA replication_Homo sapiens_hsa030302.08929481
21Phototransduction_Homo sapiens_hsa047442.03089070
22Glycerolipid metabolism_Homo sapiens_hsa005611.87375027
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.85134391
24Circadian rhythm_Homo sapiens_hsa047101.75197765
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.71210428
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.70082607
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.69292548
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68612930
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.63554472
30Ether lipid metabolism_Homo sapiens_hsa005651.60232949
31p53 signaling pathway_Homo sapiens_hsa041151.53351992
32Nicotine addiction_Homo sapiens_hsa050331.51647202
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.50260458
34Amphetamine addiction_Homo sapiens_hsa050311.49931958
35Huntingtons disease_Homo sapiens_hsa050161.49881450
36Folate biosynthesis_Homo sapiens_hsa007901.48094772
37PPAR signaling pathway_Homo sapiens_hsa033201.47461476
38RNA transport_Homo sapiens_hsa030131.44564482
39Gap junction_Homo sapiens_hsa045401.44048928
40mRNA surveillance pathway_Homo sapiens_hsa030151.43529629
41Thyroid cancer_Homo sapiens_hsa052161.36575804
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35083835
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.30947382
44RNA polymerase_Homo sapiens_hsa030201.20177533
45Carbon metabolism_Homo sapiens_hsa012001.16250235
46Fructose and mannose metabolism_Homo sapiens_hsa000511.16157565
47Mineral absorption_Homo sapiens_hsa049781.13167858
48Purine metabolism_Homo sapiens_hsa002301.13120630
49Morphine addiction_Homo sapiens_hsa050321.12718476
50Renin secretion_Homo sapiens_hsa049241.10540947
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06229229
52Fat digestion and absorption_Homo sapiens_hsa049751.05885603
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05559026
54Cardiac muscle contraction_Homo sapiens_hsa042601.01834491
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01542137
56TGF-beta signaling pathway_Homo sapiens_hsa043500.99492959
57GABAergic synapse_Homo sapiens_hsa047270.97012682
58Fatty acid elongation_Homo sapiens_hsa000620.94350221
59Fatty acid metabolism_Homo sapiens_hsa012120.90859916
60Cell cycle_Homo sapiens_hsa041100.89346654
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88559830
62Antigen processing and presentation_Homo sapiens_hsa046120.88541654
63Biosynthesis of amino acids_Homo sapiens_hsa012300.87194429
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86718353
65RNA degradation_Homo sapiens_hsa030180.85403043
66Homologous recombination_Homo sapiens_hsa034400.83808009
67Fatty acid degradation_Homo sapiens_hsa000710.82543733
68Arachidonic acid metabolism_Homo sapiens_hsa005900.80813987
69Renin-angiotensin system_Homo sapiens_hsa046140.80738394
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79085537
71Estrogen signaling pathway_Homo sapiens_hsa049150.78880331
72Serotonergic synapse_Homo sapiens_hsa047260.78811401
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78038407
74Long-term potentiation_Homo sapiens_hsa047200.76446078
75Glutathione metabolism_Homo sapiens_hsa004800.75060022
76Hedgehog signaling pathway_Homo sapiens_hsa043400.74673636
77Ovarian steroidogenesis_Homo sapiens_hsa049130.73832439
78Adherens junction_Homo sapiens_hsa045200.73344062
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69925888
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69133261
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68790938
82Collecting duct acid secretion_Homo sapiens_hsa049660.67274701
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64774806
84Long-term depression_Homo sapiens_hsa047300.63343855
85Vitamin digestion and absorption_Homo sapiens_hsa049770.63217953
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59404729
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57632509
88ABC transporters_Homo sapiens_hsa020100.57314226
89Insulin secretion_Homo sapiens_hsa049110.56465112
90Chemical carcinogenesis_Homo sapiens_hsa052040.56323155
91Small cell lung cancer_Homo sapiens_hsa052220.55017053
92FoxO signaling pathway_Homo sapiens_hsa040680.53152020
93Systemic lupus erythematosus_Homo sapiens_hsa053220.51585891
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51323001
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49492519
96Inositol phosphate metabolism_Homo sapiens_hsa005620.49316137
97Calcium signaling pathway_Homo sapiens_hsa040200.46332199
98VEGF signaling pathway_Homo sapiens_hsa043700.45965316
99Thyroid hormone synthesis_Homo sapiens_hsa049180.45668399
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.45110756
101AMPK signaling pathway_Homo sapiens_hsa041520.44766619
102Regulation of autophagy_Homo sapiens_hsa041400.44049675
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.42487255
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40497674
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38483286
106Oxytocin signaling pathway_Homo sapiens_hsa049210.38304032
107N-Glycan biosynthesis_Homo sapiens_hsa005100.37961014
108mTOR signaling pathway_Homo sapiens_hsa041500.37786734
109ErbB signaling pathway_Homo sapiens_hsa040120.37775772
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.37150171
111Pyrimidine metabolism_Homo sapiens_hsa002400.37121735
112Endocytosis_Homo sapiens_hsa041440.37110982
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37004523
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36411050
115Metabolic pathways_Homo sapiens_hsa011000.36341140
116Taste transduction_Homo sapiens_hsa047420.35785091
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35562705
118Hippo signaling pathway_Homo sapiens_hsa043900.35463567
119Bile secretion_Homo sapiens_hsa049760.34361111
120* Viral carcinogenesis_Homo sapiens_hsa052030.34201877
121HTLV-I infection_Homo sapiens_hsa051660.33235898
122Synaptic vesicle cycle_Homo sapiens_hsa047210.32885901
123Pancreatic secretion_Homo sapiens_hsa049720.31915653
124MicroRNAs in cancer_Homo sapiens_hsa052060.31217061
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.30833509
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30796629
127Base excision repair_Homo sapiens_hsa034100.30310995
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29273031
129Protein digestion and absorption_Homo sapiens_hsa049740.28714567
130ECM-receptor interaction_Homo sapiens_hsa045120.27914329
131Circadian entrainment_Homo sapiens_hsa047130.27071841
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26648548
133Non-homologous end-joining_Homo sapiens_hsa034500.26532309
134Legionellosis_Homo sapiens_hsa051340.26477864
135Salivary secretion_Homo sapiens_hsa049700.23355878
136Wnt signaling pathway_Homo sapiens_hsa043100.22727461
137Herpes simplex infection_Homo sapiens_hsa051680.22582839
138cAMP signaling pathway_Homo sapiens_hsa040240.22431281
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21506124
140Gastric acid secretion_Homo sapiens_hsa049710.21124025
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.20720977
142Ras signaling pathway_Homo sapiens_hsa040140.20130619
143Cocaine addiction_Homo sapiens_hsa050300.19463052
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17302920
145Alcoholism_Homo sapiens_hsa050340.17109419
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16941814
147Arginine and proline metabolism_Homo sapiens_hsa003300.16190950
148Sphingolipid metabolism_Homo sapiens_hsa006000.15885016
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.15363354
150Glutamatergic synapse_Homo sapiens_hsa047240.12759453
151Olfactory transduction_Homo sapiens_hsa047400.12623401
152Cholinergic synapse_Homo sapiens_hsa047250.11180935
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10837058
154Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10255628
155Endometrial cancer_Homo sapiens_hsa052130.09548613
156Tight junction_Homo sapiens_hsa045300.08775940
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07430693
158Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.07330681

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