GSTTP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.12805451
2response to pheromone (GO:0019236)4.56503270
3negative regulation of telomere maintenance (GO:0032205)4.46516006
4DNA deamination (GO:0045006)4.17663688
5L-fucose catabolic process (GO:0042355)4.13407215
6fucose catabolic process (GO:0019317)4.13407215
7L-fucose metabolic process (GO:0042354)4.13407215
8cellular ketone body metabolic process (GO:0046950)3.82335434
9kynurenine metabolic process (GO:0070189)3.72275428
10water-soluble vitamin biosynthetic process (GO:0042364)3.69603649
11tryptophan catabolic process (GO:0006569)3.64342352
12indole-containing compound catabolic process (GO:0042436)3.64342352
13indolalkylamine catabolic process (GO:0046218)3.64342352
14protein polyglutamylation (GO:0018095)3.64220719
15indolalkylamine metabolic process (GO:0006586)3.63813702
16ketone body metabolic process (GO:1902224)3.46566552
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.40006224
18detection of light stimulus involved in sensory perception (GO:0050962)3.36275414
19detection of light stimulus involved in visual perception (GO:0050908)3.36275414
20piRNA metabolic process (GO:0034587)3.32590811
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26779493
22regulation of glucokinase activity (GO:0033131)3.21574784
23regulation of hexokinase activity (GO:1903299)3.21574784
24platelet dense granule organization (GO:0060155)3.19371354
25tryptophan metabolic process (GO:0006568)3.19162597
26G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16868927
27sulfation (GO:0051923)3.11519182
28multicellular organism reproduction (GO:0032504)3.11150480
29sperm motility (GO:0030317)3.10627916
30neuronal action potential (GO:0019228)3.06438493
31protein complex biogenesis (GO:0070271)2.99674081
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99342488
33mitochondrial respiratory chain complex I assembly (GO:0032981)2.99342488
34NADH dehydrogenase complex assembly (GO:0010257)2.99342488
35rRNA catabolic process (GO:0016075)2.99097929
36gamma-aminobutyric acid transport (GO:0015812)2.97053599
37epithelial cilium movement (GO:0003351)2.95507826
38cytidine metabolic process (GO:0046087)2.92372306
39cytidine catabolic process (GO:0006216)2.92372306
40cytidine deamination (GO:0009972)2.92372306
41regulation of action potential (GO:0098900)2.91190645
42male meiosis I (GO:0007141)2.90759136
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.90107823
44regulation of telomere maintenance (GO:0032204)2.88770062
45protein neddylation (GO:0045116)2.86606974
46regulation of cilium movement (GO:0003352)2.86009997
47indole-containing compound metabolic process (GO:0042430)2.85744208
48kidney morphogenesis (GO:0060993)2.85452356
49reflex (GO:0060004)2.81990019
50nephron tubule morphogenesis (GO:0072078)2.80811569
51nephron epithelium morphogenesis (GO:0072088)2.80811569
52negative regulation of mast cell activation (GO:0033004)2.80769693
53regulation of rhodopsin mediated signaling pathway (GO:0022400)2.76991795
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.76930787
55preassembly of GPI anchor in ER membrane (GO:0016254)2.76850645
56mitochondrial respiratory chain complex assembly (GO:0033108)2.76245115
57behavioral response to ethanol (GO:0048149)2.74992444
58axoneme assembly (GO:0035082)2.73800386
59neural tube formation (GO:0001841)2.72567125
60rhodopsin mediated signaling pathway (GO:0016056)2.70341425
61primary amino compound metabolic process (GO:1901160)2.68047484
62DNA methylation involved in gamete generation (GO:0043046)2.66792688
63photoreceptor cell development (GO:0042461)2.66739527
64exogenous drug catabolic process (GO:0042738)2.66683683
65cornea development in camera-type eye (GO:0061303)2.66668386
66startle response (GO:0001964)2.65836304
67cellular biogenic amine catabolic process (GO:0042402)2.63673491
68amine catabolic process (GO:0009310)2.63673491
69protein-cofactor linkage (GO:0018065)2.63186914
70respiratory chain complex IV assembly (GO:0008535)2.60149125
71synaptic transmission, cholinergic (GO:0007271)2.58611584
72protein K6-linked ubiquitination (GO:0085020)2.58386071
73cilium movement (GO:0003341)2.55708984
74L-methionine salvage (GO:0071267)2.53486174
75L-methionine biosynthetic process (GO:0071265)2.53486174
76amino acid salvage (GO:0043102)2.53486174
77rRNA modification (GO:0000154)2.53054742
78regulation of memory T cell differentiation (GO:0043380)2.52460144
79acrosome reaction (GO:0007340)2.51903779
80rRNA methylation (GO:0031167)2.51834669
81nonmotile primary cilium assembly (GO:0035058)2.51265785
82adaptation of signaling pathway (GO:0023058)2.50996705
83glycerophospholipid catabolic process (GO:0046475)2.50922944
84serotonin metabolic process (GO:0042428)2.50550553
85adenosine metabolic process (GO:0046085)2.49444960
86male meiosis (GO:0007140)2.49405196
87pyrimidine ribonucleoside catabolic process (GO:0046133)2.48777264
88regulation of nuclear cell cycle DNA replication (GO:0033262)2.47889841
89cilium morphogenesis (GO:0060271)2.47847219
90endoderm formation (GO:0001706)2.47821626
91ubiquinone biosynthetic process (GO:0006744)2.46678935
92cilium or flagellum-dependent cell motility (GO:0001539)2.46404531
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45989946
94negative regulation of multicellular organism growth (GO:0040015)2.45601451
95positive regulation of guanylate cyclase activity (GO:0031284)2.45083971
96somite rostral/caudal axis specification (GO:0032525)2.45039104
97DNA double-strand break processing (GO:0000729)2.44808477
98mannosylation (GO:0097502)2.44255015
99nucleobase catabolic process (GO:0046113)2.43942415
100drug catabolic process (GO:0042737)2.43145210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.56871968
2VDR_22108803_ChIP-Seq_LS180_Human3.27164481
3EZH2_22144423_ChIP-Seq_EOC_Human3.15473370
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09375743
5GBX2_23144817_ChIP-Seq_PC3_Human2.76351399
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47006725
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37624481
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29842936
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29083547
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27651468
11IGF1R_20145208_ChIP-Seq_DFB_Human2.26505444
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21526283
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19685444
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18632826
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.05332890
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.03817565
17TAF15_26573619_Chip-Seq_HEK293_Human2.02591435
18FUS_26573619_Chip-Seq_HEK293_Human1.99809674
19ER_23166858_ChIP-Seq_MCF-7_Human1.94903551
20P300_19829295_ChIP-Seq_ESCs_Human1.91586207
21EWS_26573619_Chip-Seq_HEK293_Human1.86605729
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79625785
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71299718
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70983228
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70853533
26BCAT_22108803_ChIP-Seq_LS180_Human1.69959547
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66830032
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65689629
29CBP_20019798_ChIP-Seq_JUKART_Human1.65689629
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.62296441
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55171698
32AR_25329375_ChIP-Seq_VCAP_Human1.53264889
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51156862
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50391739
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50224079
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48329254
37SMAD4_21799915_ChIP-Seq_A2780_Human1.46510607
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44498573
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43979803
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43350272
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42391505
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42010946
43REST_21632747_ChIP-Seq_MESCs_Mouse1.41302257
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.40332510
45TP53_22573176_ChIP-Seq_HFKS_Human1.40166986
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.38769332
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38426197
48STAT3_23295773_ChIP-Seq_U87_Human1.38193461
49SOX2_19829295_ChIP-Seq_ESCs_Human1.37910802
50NANOG_19829295_ChIP-Seq_ESCs_Human1.37910802
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35242821
52TCF4_23295773_ChIP-Seq_U87_Human1.35080259
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.34217066
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.33503340
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33503340
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32774598
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31775780
58MYC_18940864_ChIP-ChIP_HL60_Human1.29640401
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29535527
60TCF4_22108803_ChIP-Seq_LS180_Human1.26643073
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26039670
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.25688452
63NCOR_22424771_ChIP-Seq_293T_Human1.24681646
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24612080
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24612080
66RUNX2_22187159_ChIP-Seq_PCA_Human1.23394549
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22871940
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.21939824
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20520336
70AR_20517297_ChIP-Seq_VCAP_Human1.19409382
71RNF2_27304074_Chip-Seq_NSC_Mouse1.19293060
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.18144263
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17784444
74IRF1_19129219_ChIP-ChIP_H3396_Human1.16392786
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.15579595
76AR_21572438_ChIP-Seq_LNCaP_Human1.12744139
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.12198467
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.12046001
79AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10904603
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09913945
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06890363
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.05827933
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.04188668
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03199824
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.02332124
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02111010
87* NANOG_20526341_ChIP-Seq_ESCs_Human1.02079632
88HOXB7_26014856_ChIP-Seq_BT474_Human1.01396417
89CDX2_22108803_ChIP-Seq_LS180_Human1.01382981
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01212025
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01105260
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99205079
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.98908065
94ERA_21632823_ChIP-Seq_H3396_Human0.98697782
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98542528
96* MYC_19829295_ChIP-Seq_ESCs_Human0.98168463
97EZH2_27304074_Chip-Seq_ESCs_Mouse0.97849157
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.96245476
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95874737
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.95638734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.08819006
2MP0003195_calcinosis2.98498693
3MP0001968_abnormal_touch/_nociception2.68564338
4MP0005551_abnormal_eye_electrophysiolog2.50204723
5MP0002102_abnormal_ear_morphology2.44645601
6MP0002837_dystrophic_cardiac_calcinosis2.40244786
7MP0002736_abnormal_nociception_after2.37293729
8MP0003646_muscle_fatigue2.35663920
9MP0003011_delayed_dark_adaptation2.23187419
10MP0005645_abnormal_hypothalamus_physiol2.15118743
11MP0002876_abnormal_thyroid_physiology2.07963586
12MP0006072_abnormal_retinal_apoptosis2.04160633
13MP0004133_heterotaxia1.95205559
14MP0003880_abnormal_central_pattern1.93586727
15MP0005410_abnormal_fertilization1.92695355
16MP0005253_abnormal_eye_physiology1.91108417
17MP0004147_increased_porphyrin_level1.90085626
18MP0008872_abnormal_physiological_respon1.90010141
19MP0009046_muscle_twitch1.89414174
20MP0009745_abnormal_behavioral_response1.89217006
21MP0001986_abnormal_taste_sensitivity1.87231743
22MP0002138_abnormal_hepatobiliary_system1.82427559
23MP0005646_abnormal_pituitary_gland1.77454781
24MP0002272_abnormal_nervous_system1.76951711
25MP0000569_abnormal_digit_pigmentation1.73014914
26MP0003787_abnormal_imprinting1.71954105
27MP0006292_abnormal_olfactory_placode1.66416251
28MP0001501_abnormal_sleep_pattern1.65820971
29MP0000372_irregular_coat_pigmentation1.63157530
30MP0003252_abnormal_bile_duct1.59901013
31MP0004885_abnormal_endolymph1.58172328
32MP0006276_abnormal_autonomic_nervous1.55842074
33MP0005084_abnormal_gallbladder_morpholo1.51640690
34MP0002938_white_spotting1.50887355
35MP0004043_abnormal_pH_regulation1.46678645
36MP0001485_abnormal_pinna_reflex1.46379081
37MP0000427_abnormal_hair_cycle1.45163748
38MP0002638_abnormal_pupillary_reflex1.45033375
39MP0005379_endocrine/exocrine_gland_phen1.44852520
40MP0004142_abnormal_muscle_tone1.43287453
41MP0001486_abnormal_startle_reflex1.40000312
42MP0002163_abnormal_gland_morphology1.37103596
43MP0003283_abnormal_digestive_organ1.34620321
44MP0005389_reproductive_system_phenotype1.34599843
45MP0002160_abnormal_reproductive_system1.33547215
46MP0008875_abnormal_xenobiotic_pharmacok1.32981324
47MP0002064_seizures1.27938353
48MP0003718_maternal_effect1.26577671
49MP0000631_abnormal_neuroendocrine_gland1.26254202
50MP0002735_abnormal_chemical_nociception1.26239774
51MP0002928_abnormal_bile_duct1.25546019
52MP0004145_abnormal_muscle_electrophysio1.23491597
53MP0003136_yellow_coat_color1.23365773
54MP0002572_abnormal_emotion/affect_behav1.21160619
55MP0002557_abnormal_social/conspecific_i1.18051147
56MP0004742_abnormal_vestibular_system1.12265065
57MP0002733_abnormal_thermal_nociception1.11159264
58MP0002067_abnormal_sensory_capabilities1.10260223
59MP0001919_abnormal_reproductive_system1.05752915
60MP0001984_abnormal_olfaction1.05175787
61MP0008995_early_reproductive_senescence1.03704529
62MP0003698_abnormal_male_reproductive1.03571001
63MP0005195_abnormal_posterior_eye1.03133938
64MP0001970_abnormal_pain_threshold1.03069475
65MP0004924_abnormal_behavior1.01042726
66MP0005386_behavior/neurological_phenoty1.01042726
67MP0001905_abnormal_dopamine_level1.00907170
68MP0002234_abnormal_pharynx_morphology1.00444001
69MP0003890_abnormal_embryonic-extraembry0.98748604
70MP0002693_abnormal_pancreas_physiology0.97527594
71MP0005167_abnormal_blood-brain_barrier0.96830690
72MP0003119_abnormal_digestive_system0.95691311
73MP0003635_abnormal_synaptic_transmissio0.94195891
74MP0002734_abnormal_mechanical_nocicepti0.91087816
75MP0001929_abnormal_gametogenesis0.90778837
76MP0005085_abnormal_gallbladder_physiolo0.90579534
77MP0001764_abnormal_homeostasis0.90539483
78MP0002063_abnormal_learning/memory/cond0.89920051
79MP0002254_reproductive_system_inflammat0.88876096
80MP0002751_abnormal_autonomic_nervous0.88135853
81MP0003121_genomic_imprinting0.86821439
82MP0002139_abnormal_hepatobiliary_system0.86391122
83MP0002277_abnormal_respiratory_mucosa0.86328103
84MP0000230_abnormal_systemic_arterial0.85486955
85MP0005332_abnormal_amino_acid0.85233686
86MP0005174_abnormal_tail_pigmentation0.85084818
87MP0002210_abnormal_sex_determination0.84297737
88MP0002752_abnormal_somatic_nervous0.81873599
89MP0000049_abnormal_middle_ear0.81558115
90MP0005075_abnormal_melanosome_morpholog0.81358774
91MP0001963_abnormal_hearing_physiology0.80178454
92MP0004215_abnormal_myocardial_fiber0.80036134
93MP0000026_abnormal_inner_ear0.79396348
94MP0008775_abnormal_heart_ventricle0.77879284
95MP0005377_hearing/vestibular/ear_phenot0.77680000
96MP0003878_abnormal_ear_physiology0.77680000
97MP0005423_abnormal_somatic_nervous0.77454689
98MP0001440_abnormal_grooming_behavior0.76870860
99MP0002653_abnormal_ependyma_morphology0.76345327
100MP0001529_abnormal_vocalization0.75650558

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.42554593
2True hermaphroditism (HP:0010459)4.25208427
3Pancreatic fibrosis (HP:0100732)4.11511103
4Congenital stationary night blindness (HP:0007642)3.98377429
5Molar tooth sign on MRI (HP:0002419)3.78858555
6Abnormality of midbrain morphology (HP:0002418)3.78858555
7Nephronophthisis (HP:0000090)3.47984524
8Pendular nystagmus (HP:0012043)3.44796132
9Chronic hepatic failure (HP:0100626)3.23473114
10Progressive cerebellar ataxia (HP:0002073)3.22576701
11Abnormality of the renal cortex (HP:0011035)3.18411152
12Cystic liver disease (HP:0006706)3.14245684
13Hyperventilation (HP:0002883)3.02392666
14Attenuation of retinal blood vessels (HP:0007843)2.94177252
15Abnormality of the renal medulla (HP:0100957)2.93179841
16Abnormal rod and cone electroretinograms (HP:0008323)2.88303304
17Type II lissencephaly (HP:0007260)2.81119599
18Increased corneal curvature (HP:0100692)2.77681194
19Keratoconus (HP:0000563)2.77681194
20Abnormality of the labia minora (HP:0012880)2.74055154
21Genetic anticipation (HP:0003743)2.72710085
22Abolished electroretinogram (ERG) (HP:0000550)2.70653199
23Renal cortical cysts (HP:0000803)2.68477103
24Decreased central vision (HP:0007663)2.68075770
25Tubular atrophy (HP:0000092)2.54480191
26Medial flaring of the eyebrow (HP:0010747)2.53537940
27Sclerocornea (HP:0000647)2.43482990
28Gaze-evoked nystagmus (HP:0000640)2.43446337
29Abnormal drinking behavior (HP:0030082)2.43417657
30Polydipsia (HP:0001959)2.43417657
31Hypothermia (HP:0002045)2.42200654
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35839182
33Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.34453855
34Methylmalonic acidemia (HP:0002912)2.27530665
35Hypoplasia of the fovea (HP:0007750)2.24358764
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.24358764
37Mitochondrial inheritance (HP:0001427)2.24297889
38Congenital, generalized hypertrichosis (HP:0004540)2.23822611
39Anencephaly (HP:0002323)2.22987950
40Inability to walk (HP:0002540)2.22187744
41Acute necrotizing encephalopathy (HP:0006965)2.20971829
42Male pseudohermaphroditism (HP:0000037)2.18057565
43Furrowed tongue (HP:0000221)2.17878216
44Optic nerve hypoplasia (HP:0000609)2.17512927
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.16050548
46Congenital hepatic fibrosis (HP:0002612)2.11754649
473-Methylglutaconic aciduria (HP:0003535)2.11068721
48Increased CSF lactate (HP:0002490)2.10227886
49Febrile seizures (HP:0002373)2.06980038
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.05785123
51Absent/shortened dynein arms (HP:0200106)2.05785123
52Large for gestational age (HP:0001520)2.03881993
53Progressive inability to walk (HP:0002505)2.03360182
54Severe visual impairment (HP:0001141)2.02865150
55Progressive macrocephaly (HP:0004481)2.02384115
56Optic disc pallor (HP:0000543)2.02351442
57Prostate neoplasm (HP:0100787)2.02109097
58Bile duct proliferation (HP:0001408)2.02043951
59Abnormal biliary tract physiology (HP:0012439)2.02043951
60Abnormality of the fovea (HP:0000493)2.00509429
61Methylmalonic aciduria (HP:0012120)2.00251044
62Hemiparesis (HP:0001269)1.98766694
63Acute encephalopathy (HP:0006846)1.98397767
64Cerebellar dysplasia (HP:0007033)1.98237999
65Focal seizures (HP:0007359)1.97961950
66Severe muscular hypotonia (HP:0006829)1.97786908
67Bony spicule pigmentary retinopathy (HP:0007737)1.97174930
68Abnormality of alanine metabolism (HP:0010916)1.95910292
69Hyperalaninemia (HP:0003348)1.95910292
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95910292
71Polyuria (HP:0000103)1.94895725
72Gait imbalance (HP:0002141)1.94828134
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93549269
74Hepatic necrosis (HP:0002605)1.91195906
75Lissencephaly (HP:0001339)1.90952625
76Chorioretinal atrophy (HP:0000533)1.90147020
77Abnormal albumin level (HP:0012116)1.89764670
78Hypoalbuminemia (HP:0003073)1.89764670
79Small hand (HP:0200055)1.89249056
80Postaxial foot polydactyly (HP:0001830)1.88699500
81Broad-based gait (HP:0002136)1.88574128
82Intestinal atresia (HP:0011100)1.88208309
83Concave nail (HP:0001598)1.87002382
84Congenital primary aphakia (HP:0007707)1.86742659
85Hyperglycinemia (HP:0002154)1.86020451
86Ketosis (HP:0001946)1.84687803
87Glycosuria (HP:0003076)1.83227049
88Abnormality of urine glucose concentration (HP:0011016)1.83227049
89Nephrogenic diabetes insipidus (HP:0009806)1.80813394
90Abnormal respiratory motile cilium morphology (HP:0005938)1.80610601
91Abnormal respiratory epithelium morphology (HP:0012253)1.80610601
92Congenital sensorineural hearing impairment (HP:0008527)1.80519355
93Genital tract atresia (HP:0001827)1.80003484
94Gastrointestinal atresia (HP:0002589)1.79230275
95Aplasia/Hypoplasia of the spleen (HP:0010451)1.79021987
96Hepatocellular necrosis (HP:0001404)1.78257445
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.77970826
98Abnormal mitochondria in muscle tissue (HP:0008316)1.76189001
99Abnormality of the pons (HP:0007361)1.75486961
100Hyperglycinuria (HP:0003108)1.75357546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.27121685
2TLK13.38893567
3ADRBK23.16955147
4MAP4K22.96222032
5GRK12.95107206
6BMPR1B2.83655218
7ZAK2.67998231
8WNK32.62695147
9PINK12.52896758
10WNK42.48939760
11ACVR1B2.20945263
12TXK2.06060668
13INSRR2.01534588
14NUAK11.98921017
15CASK1.97083598
16OXSR11.94749030
17MAPK131.92137201
18PNCK1.39405364
19TAOK31.39036455
20STK391.37646182
21TNIK1.31281898
22DAPK21.29622688
23MKNK21.23099649
24DYRK21.19007518
25NTRK31.14815946
26PAK31.14456994
27BRSK21.11820010
28MAP3K41.09665320
29BCKDK1.09503752
30VRK11.05478774
31PLK40.99786993
32PRKCG0.99248702
33MAP2K60.98593248
34MARK10.90922844
35PLK20.90582239
36STK38L0.90416931
37ADRBK10.89735191
38PRKCE0.88571740
39TRIM280.87332661
40MUSK0.86963234
41FGFR20.85602423
42MST40.83484724
43MAPK150.80594415
44TIE10.79179507
45PTK2B0.79039011
46VRK20.77232333
47CAMKK20.76702386
48CSNK1G20.75894591
49PHKG10.72887015
50PHKG20.72887015
51MAPKAPK30.72644392
52BCR0.72199744
53SIK20.72097176
54STK160.70416909
55MAP2K70.69230597
56MKNK10.68476511
57CSNK1G30.67808739
58CSNK1G10.66282819
59TAF10.65593024
60MAPKAPK50.64933820
61WEE10.64191226
62CDK190.61253744
63TGFBR10.58984606
64PKN10.58131133
65PIK3CA0.57429583
66CAMK2A0.57391208
67PRKCQ0.57242433
68TEC0.57101536
69PLK30.54792526
70IKBKB0.54414307
71NME10.51198671
72FER0.50429695
73ITK0.48597418
74CAMK10.48142084
75PRKACA0.47970334
76RPS6KA50.47305501
77GRK60.46592940
78CSNK1A1L0.45997925
79EPHA40.45152758
80STK110.43783716
81EIF2AK30.41086717
82PRKAA20.40908102
83PRKCZ0.40182252
84NTRK20.39396147
85GRK70.38923925
86ERBB30.36796803
87PRKCA0.36528139
88PRKAA10.35752088
89CSNK1A10.34702436
90IRAK10.32645033
91CAMK2D0.31095189
92AKT30.30864737
93STK30.30837519
94MAP3K70.30187836
95PRKG10.28644717
96PLK10.28558620
97CSNK1D0.28427966
98PRKCI0.27405425
99BUB10.26858555
100MINK10.26804104

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.08884034
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.70455303
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.64308705
4Protein export_Homo sapiens_hsa030602.50985305
5Butanoate metabolism_Homo sapiens_hsa006502.40033621
6Linoleic acid metabolism_Homo sapiens_hsa005912.39640628
7Oxidative phosphorylation_Homo sapiens_hsa001902.33347348
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26516773
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11226893
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95564113
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89646834
12Nitrogen metabolism_Homo sapiens_hsa009101.86608884
13Caffeine metabolism_Homo sapiens_hsa002321.84140775
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81232757
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81221760
16Nicotine addiction_Homo sapiens_hsa050331.80616669
17RNA polymerase_Homo sapiens_hsa030201.80547247
18Selenocompound metabolism_Homo sapiens_hsa004501.80470011
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.80393570
20Homologous recombination_Homo sapiens_hsa034401.78189336
21Parkinsons disease_Homo sapiens_hsa050121.75826649
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75376797
23Tryptophan metabolism_Homo sapiens_hsa003801.75165570
24Olfactory transduction_Homo sapiens_hsa047401.72873834
25Propanoate metabolism_Homo sapiens_hsa006401.58265297
26Ether lipid metabolism_Homo sapiens_hsa005651.55560586
27Fanconi anemia pathway_Homo sapiens_hsa034601.51933804
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47090387
29Taste transduction_Homo sapiens_hsa047421.33808889
30Chemical carcinogenesis_Homo sapiens_hsa052041.24973645
31Retinol metabolism_Homo sapiens_hsa008301.24548298
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.22333331
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21729114
34ABC transporters_Homo sapiens_hsa020101.20700865
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.20584199
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20275420
37Cardiac muscle contraction_Homo sapiens_hsa042601.17260860
38Peroxisome_Homo sapiens_hsa041461.15865861
39Insulin secretion_Homo sapiens_hsa049111.11445736
40Type I diabetes mellitus_Homo sapiens_hsa049401.11350969
41Alzheimers disease_Homo sapiens_hsa050101.11277810
42Morphine addiction_Homo sapiens_hsa050321.09153737
43Huntingtons disease_Homo sapiens_hsa050161.08599164
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06507201
45Basal transcription factors_Homo sapiens_hsa030221.04844467
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00484193
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00106424
48Fat digestion and absorption_Homo sapiens_hsa049750.97691321
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93598523
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92628874
51RNA degradation_Homo sapiens_hsa030180.89907804
52Arachidonic acid metabolism_Homo sapiens_hsa005900.89517449
53Primary immunodeficiency_Homo sapiens_hsa053400.85271198
54Asthma_Homo sapiens_hsa053100.82267812
55Glutamatergic synapse_Homo sapiens_hsa047240.82243716
56Regulation of autophagy_Homo sapiens_hsa041400.82097345
57Proteasome_Homo sapiens_hsa030500.82000177
58GABAergic synapse_Homo sapiens_hsa047270.81749383
59Serotonergic synapse_Homo sapiens_hsa047260.80278013
60Sulfur metabolism_Homo sapiens_hsa009200.78217498
61Mineral absorption_Homo sapiens_hsa049780.77938303
62Fatty acid elongation_Homo sapiens_hsa000620.77380593
63Circadian entrainment_Homo sapiens_hsa047130.76350480
64Vitamin digestion and absorption_Homo sapiens_hsa049770.74797004
65Ovarian steroidogenesis_Homo sapiens_hsa049130.74228815
66Purine metabolism_Homo sapiens_hsa002300.72969476
67Autoimmune thyroid disease_Homo sapiens_hsa053200.71964918
68Allograft rejection_Homo sapiens_hsa053300.71725061
69Graft-versus-host disease_Homo sapiens_hsa053320.69617338
70One carbon pool by folate_Homo sapiens_hsa006700.67621690
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67587184
72Histidine metabolism_Homo sapiens_hsa003400.67006153
73Salivary secretion_Homo sapiens_hsa049700.66854345
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66159987
75Glycerolipid metabolism_Homo sapiens_hsa005610.65705324
76beta-Alanine metabolism_Homo sapiens_hsa004100.65660553
77Metabolic pathways_Homo sapiens_hsa011000.61644565
78Fatty acid biosynthesis_Homo sapiens_hsa000610.61385479
79Collecting duct acid secretion_Homo sapiens_hsa049660.60582635
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60478899
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57647813
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57226803
83Calcium signaling pathway_Homo sapiens_hsa040200.55057502
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54476515
85Pyrimidine metabolism_Homo sapiens_hsa002400.51871023
86Hedgehog signaling pathway_Homo sapiens_hsa043400.51639774
87Fatty acid degradation_Homo sapiens_hsa000710.51090656
88Circadian rhythm_Homo sapiens_hsa047100.50595695
89Dorso-ventral axis formation_Homo sapiens_hsa043200.49772326
90Cocaine addiction_Homo sapiens_hsa050300.47160538
91Fatty acid metabolism_Homo sapiens_hsa012120.47110897
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.45623467
93Steroid biosynthesis_Homo sapiens_hsa001000.43752526
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40502149
95Non-homologous end-joining_Homo sapiens_hsa034500.38229196
96Amphetamine addiction_Homo sapiens_hsa050310.37209810
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36477422
98Arginine and proline metabolism_Homo sapiens_hsa003300.33959452
99Long-term depression_Homo sapiens_hsa047300.31963968
100Rheumatoid arthritis_Homo sapiens_hsa053230.31935429

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