GSTT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.94532122
2L-phenylalanine catabolic process (GO:0006559)6.94532122
3L-phenylalanine metabolic process (GO:0006558)6.82061793
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.82061793
5aromatic amino acid family catabolic process (GO:0009074)6.34822629
6indole-containing compound catabolic process (GO:0042436)5.83164147
7indolalkylamine catabolic process (GO:0046218)5.83164147
8tryptophan catabolic process (GO:0006569)5.83164147
9glyoxylate metabolic process (GO:0046487)5.74402557
10proteasome assembly (GO:0043248)5.74236452
11cysteine metabolic process (GO:0006534)5.58998250
12kynurenine metabolic process (GO:0070189)5.52559176
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50730361
14tryptophan metabolic process (GO:0006568)5.47497390
15lysine metabolic process (GO:0006553)5.24536038
16lysine catabolic process (GO:0006554)5.24536038
17bile acid biosynthetic process (GO:0006699)5.13299072
18sulfur amino acid catabolic process (GO:0000098)5.09079887
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.05484349
20serine family amino acid catabolic process (GO:0009071)5.04535760
21urea metabolic process (GO:0019627)4.91180463
22urea cycle (GO:0000050)4.91180463
23alpha-linolenic acid metabolic process (GO:0036109)4.90202148
24homocysteine metabolic process (GO:0050667)4.76853229
25amino-acid betaine metabolic process (GO:0006577)4.73566603
26urate metabolic process (GO:0046415)4.65506021
27aromatic amino acid family metabolic process (GO:0009072)4.63327496
28high-density lipoprotein particle remodeling (GO:0034375)4.61691784
29drug catabolic process (GO:0042737)4.57405550
30nitrogen cycle metabolic process (GO:0071941)4.56749666
31protein maturation by protein folding (GO:0022417)4.54988360
32negative regulation of fibrinolysis (GO:0051918)4.53655770
33drug transmembrane transport (GO:0006855)4.51703146
34alpha-amino acid catabolic process (GO:1901606)4.43165348
35negative regulation of cholesterol transport (GO:0032375)4.42501188
36negative regulation of sterol transport (GO:0032372)4.42501188
37serine family amino acid metabolic process (GO:0009069)4.40430265
38bile acid metabolic process (GO:0008206)4.37167510
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.34642115
40glycine metabolic process (GO:0006544)4.34414976
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.33201830
42protein carboxylation (GO:0018214)4.25963767
43peptidyl-glutamic acid carboxylation (GO:0017187)4.25963767
44cellular ketone body metabolic process (GO:0046950)4.24312722
45regulation of fibrinolysis (GO:0051917)4.23576457
46regulation of triglyceride catabolic process (GO:0010896)4.21113122
47serine family amino acid biosynthetic process (GO:0009070)4.20813281
48regulation of cholesterol esterification (GO:0010872)4.19016425
49short-chain fatty acid metabolic process (GO:0046459)4.16145187
50cellular amino acid catabolic process (GO:0009063)4.15673087
51complement activation, alternative pathway (GO:0006957)4.11312617
52tyrosine metabolic process (GO:0006570)4.11183418
53exogenous drug catabolic process (GO:0042738)4.06537398
54ethanol oxidation (GO:0006069)4.05549202
55indolalkylamine metabolic process (GO:0006586)4.05090524
56benzene-containing compound metabolic process (GO:0042537)4.04144762
57cellular modified amino acid catabolic process (GO:0042219)4.03125705
58cellular biogenic amine catabolic process (GO:0042402)4.02659965
59amine catabolic process (GO:0009310)4.02659965
60valine metabolic process (GO:0006573)4.02343459
61regulation of mitochondrial translation (GO:0070129)4.01702971
62regulation of protein activation cascade (GO:2000257)4.01052272
63aldehyde catabolic process (GO:0046185)4.00611546
64protein-lipid complex remodeling (GO:0034368)3.99102103
65macromolecular complex remodeling (GO:0034367)3.99102103
66plasma lipoprotein particle remodeling (GO:0034369)3.99102103
67reverse cholesterol transport (GO:0043691)3.97506782
68phospholipid efflux (GO:0033700)3.96648904
69drug transport (GO:0015893)3.95195812
70cellular glucuronidation (GO:0052695)3.92011386
71triglyceride homeostasis (GO:0070328)3.88092160
72acylglycerol homeostasis (GO:0055090)3.88092160
73chaperone-mediated protein transport (GO:0072321)3.87694554
74flavonoid metabolic process (GO:0009812)3.85431540
75glutamate metabolic process (GO:0006536)3.82593481
76fatty acid beta-oxidation (GO:0006635)3.78405597
77imidazole-containing compound metabolic process (GO:0052803)3.78079116
78organic acid catabolic process (GO:0016054)3.77941312
79carboxylic acid catabolic process (GO:0046395)3.77941312
80carnitine metabolic process (GO:0009437)3.75934355
81protein complex biogenesis (GO:0070271)3.75597598
82aspartate family amino acid catabolic process (GO:0009068)3.73844517
83plasma lipoprotein particle clearance (GO:0034381)3.73011652
84regulation of complement activation (GO:0030449)3.72949193
852-oxoglutarate metabolic process (GO:0006103)3.72386491
86drug metabolic process (GO:0017144)3.71326558
87fatty acid oxidation (GO:0019395)3.70989841
88bile acid and bile salt transport (GO:0015721)3.69101921
89ketone body metabolic process (GO:1902224)3.64480019
90lipid oxidation (GO:0034440)3.63902691
91coenzyme catabolic process (GO:0009109)3.61863823
92establishment of protein localization to mitochondrial membrane (GO:0090151)3.60786100
93monocarboxylic acid catabolic process (GO:0072329)3.60034823
94arginine metabolic process (GO:0006525)3.59567465
95glucuronate metabolic process (GO:0019585)3.56929917
96uronic acid metabolic process (GO:0006063)3.56929917
97acetyl-CoA metabolic process (GO:0006084)3.56205076
98respiratory electron transport chain (GO:0022904)3.55605216
99fatty acid catabolic process (GO:0009062)3.54640110
100mitochondrial respiratory chain complex assembly (GO:0033108)3.54062631
101respiratory chain complex IV assembly (GO:0008535)3.51253988
102ATP synthesis coupled proton transport (GO:0015986)3.48768741
103energy coupled proton transport, down electrochemical gradient (GO:0015985)3.48768741
104cellular response to zinc ion (GO:0071294)3.47562631
105branched-chain amino acid metabolic process (GO:0009081)3.47280945
106electron transport chain (GO:0022900)3.47132508
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.46562521
108plasma lipoprotein particle assembly (GO:0034377)3.43431434
109branched-chain amino acid catabolic process (GO:0009083)3.43406681
110response to nitrosative stress (GO:0051409)3.40275946
111regulation of cholesterol homeostasis (GO:2000188)3.38761475
112pyridine nucleotide biosynthetic process (GO:0019363)3.38097751
113nicotinamide nucleotide biosynthetic process (GO:0019359)3.38097751
114low-density lipoprotein particle remodeling (GO:0034374)3.37193348
115NAD biosynthetic process (GO:0009435)3.34813531
116positive regulation of lipoprotein lipase activity (GO:0051006)3.34314269
117cytochrome complex assembly (GO:0017004)3.27288175
118glutathione derivative biosynthetic process (GO:1901687)3.22515558
119glutathione derivative metabolic process (GO:1901685)3.22515558
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20574812
121negative regulation of ligase activity (GO:0051352)3.18490731
122negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18490731
123positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17959078
124regulation of cellular amino acid metabolic process (GO:0006521)3.10525423
125mitochondrial respiratory chain complex I assembly (GO:0032981)3.04870993
126NADH dehydrogenase complex assembly (GO:0010257)3.04870993
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04870993
128establishment of integrated proviral latency (GO:0075713)2.98515428
129transcription elongation from RNA polymerase III promoter (GO:0006385)2.92933983
130termination of RNA polymerase III transcription (GO:0006386)2.92933983
131ventricular cardiac muscle cell development (GO:0055015)2.90957004
132cullin deneddylation (GO:0010388)2.90606987
133protein deneddylation (GO:0000338)2.88684435
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87665037
135DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82952640
136intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75384629
137signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75384629
138signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71481186
139signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71481186
140signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71481186
141establishment of viral latency (GO:0019043)2.70610117
142atrioventricular valve morphogenesis (GO:0003181)2.69588812
143sequestering of extracellular ligand from receptor (GO:0035581)2.66853580
144kidney mesenchyme development (GO:0072074)2.65913721
145protein localization to kinetochore (GO:0034501)2.65653380
146regulation of metalloenzyme activity (GO:0048552)2.64704394
147skin morphogenesis (GO:0043589)2.63907874
148protein autoprocessing (GO:0016540)2.63853642
149transcription from mitochondrial promoter (GO:0006390)2.61058665
150positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.60885837
151signal transduction involved in DNA integrity checkpoint (GO:0072401)2.59842784
152signal transduction involved in DNA damage checkpoint (GO:0072422)2.59842784
153deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57056457
154signal transduction involved in cell cycle checkpoint (GO:0072395)2.52332475
155negative regulation of JAK-STAT cascade (GO:0046426)2.49057071
156water-soluble vitamin biosynthetic process (GO:0042364)2.48640231
157negative regulation of chondrocyte differentiation (GO:0032331)2.48162804
158nucleoside salvage (GO:0043174)2.47140610
159positive regulation of ligase activity (GO:0051351)2.46628696
160protein targeting to mitochondrion (GO:0006626)2.44137510
161protein heterotetramerization (GO:0051290)2.41610003
162nuclear envelope reassembly (GO:0031468)2.41167002
163mitotic nuclear envelope reassembly (GO:0007084)2.41167002
164mannosylation (GO:0097502)2.39864440
165pteridine-containing compound biosynthetic process (GO:0042559)2.39424949
166regulation of ubiquitin-protein transferase activity (GO:0051438)2.38253746
167lactate metabolic process (GO:0006089)2.37296929
168metanephric mesenchyme development (GO:0072075)2.35040664
169negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.33398510
170positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.31270546
171rRNA modification (GO:0000154)2.28657957
172chondrocyte proliferation (GO:0035988)2.27864591
173regulation of ligase activity (GO:0051340)2.27186089
174GTP biosynthetic process (GO:0006183)2.26775239
175GDP-mannose metabolic process (GO:0019673)2.26612680
176cellular response to cadmium ion (GO:0071276)2.26534434
177protein localization to mitochondrion (GO:0070585)2.25640142
178rRNA methylation (GO:0031167)2.24533203
179extracellular regulation of signal transduction (GO:1900115)2.24320023
180extracellular negative regulation of signal transduction (GO:1900116)2.24320023
181regulation of cellular amine metabolic process (GO:0033238)2.24090657
182pattern specification involved in kidney development (GO:0061004)2.21553394
183heart process (GO:0003015)2.20644976
184heart contraction (GO:0060047)2.20644976
185tRNA methylation (GO:0030488)2.19590103
186response to redox state (GO:0051775)2.19360161
187negative regulation of receptor activity (GO:2000272)2.19160947
188establishment of protein localization to mitochondrion (GO:0072655)2.18870001
189negative regulation of protein ubiquitination (GO:0031397)2.18216775
190endothelial cell chemotaxis (GO:0035767)2.17284795
191ribosomal large subunit biogenesis (GO:0042273)2.17143849
192purine nucleoside triphosphate biosynthetic process (GO:0009145)2.16929294
193positive regulation of cell cycle arrest (GO:0071158)2.16878933
194endocardial cushion development (GO:0003197)2.16803853
195nucleoside transmembrane transport (GO:1901642)2.16676484
196positive regulation of actin filament depolymerization (GO:0030836)2.16110466
197ribosome assembly (GO:0042255)2.14970077
198DNA damage response, detection of DNA damage (GO:0042769)2.14961285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.10299721
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.27841201
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.83358896
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.26818110
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.20836997
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.57885054
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42480043
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.18422575
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.83724508
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.74792231
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.36268720
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25806548
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98313919
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.89016158
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.81415547
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73157277
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.55294092
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.52210573
19ELK1_19687146_ChIP-ChIP_HELA_Human2.49499508
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.48650737
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.47405680
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47358790
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.46815424
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.37743196
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33972993
26IRF8_22096565_ChIP-ChIP_GC-B_Human2.32879489
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32654644
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10409539
29DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.00454074
30GATA1_22025678_ChIP-Seq_K562_Human2.00334708
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0222953
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88062358
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86184825
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81718892
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74241209
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.73420503
37ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.70187532
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69263809
39ELK1_22589737_ChIP-Seq_MCF10A_Human1.68131463
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67677644
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66771552
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60604152
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57686141
44EOMES_21245162_ChIP-Seq_HESCs_Human1.55812190
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52349918
46DCP1A_22483619_ChIP-Seq_HELA_Human1.49827427
47* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46388122
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46379949
49CLOCK_20551151_ChIP-Seq_293T_Human1.45758595
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42998760
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36798838
52E2F7_22180533_ChIP-Seq_HELA_Human1.36518239
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33160495
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32411641
55GABP_19822575_ChIP-Seq_HepG2_Human1.32343440
56SOX17_20123909_ChIP-Seq_XEN_Mouse1.30796522
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24681364
58MYC_18940864_ChIP-ChIP_HL60_Human1.22770810
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22208808
60VDR_23849224_ChIP-Seq_CD4+_Human1.20026775
61HNF4A_19822575_ChIP-Seq_HepG2_Human1.19844730
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19167730
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18652705
64BRD4_25478319_ChIP-Seq_HGPS_Human1.18415281
65MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17612903
66* NANOG_16153702_ChIP-ChIP_HESCs_Human1.17160240
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16921466
68RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16252070
69TTF2_22483619_ChIP-Seq_HELA_Human1.13246165
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12063031
71* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10738645
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08748974
73* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08649827
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07786683
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07424167
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06864149
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.05580378
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03251877
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02408847
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02408847
81* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02298250
82XRN2_22483619_ChIP-Seq_HELA_Human1.01772601
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01503217
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01221824
85SCL_19346495_ChIP-Seq_HPC-7_Human1.00930458
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00638106
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99960515
88RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99521493
89ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99087750
90* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97077030
91CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96673086
92GATA4_25053715_ChIP-Seq_YYC3_Human0.96433556
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95703840
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.94804890
95CJUN_26792858_Chip-Seq_BT549_Human0.94601884
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94351941
97TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93452520
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93205055
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92164369
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91537112
101JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90637356
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89971212
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89332537
104POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89251889
105* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88825444
106ATF3_27146783_Chip-Seq_COLON_Human0.87813251
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87472235
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87321292
109* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87185467
110SOX2_20726797_ChIP-Seq_SW620_Human0.86698837
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86296991
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85556955
113FOXP3_21729870_ChIP-Seq_TREG_Human0.84729729
114* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84306992
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83824355
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83629076
117ELF5_23300383_ChIP-Seq_T47D_Human0.83034692
118* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81075086
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.81050104
120ZNF263_19887448_ChIP-Seq_K562_Human0.80819122
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80786981
122SRF_21415370_ChIP-Seq_HL-1_Mouse0.80639928
123LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80006211
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.79634444
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79503497
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.78812057
127LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78666276
128* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78551061
129KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78248382
130LXR_22292898_ChIP-Seq_THP-1_Human0.78157382
131BP1_19119308_ChIP-ChIP_Hs578T_Human0.76975587
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.76868766
133GATA4_21415370_ChIP-Seq_HL-1_Mouse0.76672251
134SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76196651
135IRF8_21731497_ChIP-ChIP_J774_Mouse0.76163355
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74187996
137* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74085554
138AR_21909140_ChIP-Seq_LNCAP_Human0.73784906
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73725031
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73508504
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.73464808
142E2F4_17652178_ChIP-ChIP_JURKAT_Human0.73387361
143* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73331387
144CBP_21632823_ChIP-Seq_H3396_Human0.73257455
145TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73162629
146HTT_18923047_ChIP-ChIP_STHdh_Human0.72749712
147CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72260851
148E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.71708936
149MYB_21317192_ChIP-Seq_ERMYB_Mouse0.71639356
150RARB_24833708_ChIP-Seq_LIVER_Mouse0.69871574
151TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.69699307
152MYC_22102868_ChIP-Seq_BL_Human0.68991061
153E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.68935734
154CEBPB_22108803_ChIP-Seq_LS180_Human0.68225768
155AR_20517297_ChIP-Seq_VCAP_Human0.68074258
156MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.67846532
157ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.67135712
158GATA6_25053715_ChIP-Seq_YYC3_Human0.65107174
159PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.65005554
160CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64803811
161E2F1_18555785_ChIP-Seq_MESCs_Mouse0.64078951
162* TET1_21451524_ChIP-Seq_MESCs_Mouse0.63719642
163PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63605700
164MAF_26560356_Chip-Seq_TH1_Human0.63542714
165BCOR_27268052_Chip-Seq_Bcells_Human0.63302650
166BCL6_27268052_Chip-Seq_Bcells_Human0.62886030
167ERG_20887958_ChIP-Seq_HPC-7_Mouse0.62789589
168* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.62708682
169* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.62402706
170IRF8_27001747_Chip-Seq_BMDM_Mouse0.62383380
171TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.62080330
172* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61817249
173Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.61624320
174* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.61411033
175ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61344464
176CDX2_20551321_ChIP-Seq_CACO-2_Human0.60836383
177* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60280319
178P300_27268052_Chip-Seq_Bcells_Human0.60007254
179MYB_26560356_Chip-Seq_TH1_Human0.59398418
180* CTCF_26484167_Chip-Seq_Bcells_Mouse0.58455028
181CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.57551966
182SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.57141077
183ESR1_21235772_ChIP-Seq_MCF-7_Human0.56930446
184* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.56683954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.39416975
2MP0005360_urolithiasis7.21249337
3MP0005365_abnormal_bile_salt5.50740354
4MP0005085_abnormal_gallbladder_physiolo5.42331727
5MP0010030_abnormal_orbit_morphology5.06584817
6MP0008875_abnormal_xenobiotic_pharmacok4.78907670
7MP0003806_abnormal_nucleotide_metabolis3.84479631
8MP0003252_abnormal_bile_duct3.41087838
9MP0008438_abnormal_cutaneous_collagen3.36247523
10MP0005332_abnormal_amino_acid3.11906763
11MP0010329_abnormal_lipoprotein_level3.03425075
12MP0003941_abnormal_skin_development3.01001196
13MP0005503_abnormal_tendon_morphology2.85411830
14MP0004272_abnormal_basement_membrane2.72278288
15MP0009840_abnormal_foam_cell2.71302590
16MP0003195_calcinosis2.66511412
17MP0005083_abnormal_biliary_tract2.62429291
18MP0001666_abnormal_nutrient_absorption2.62144816
19MP0004019_abnormal_vitamin_homeostasis2.61388540
20MP0009384_cardiac_valve_regurgitation2.49586716
21MP0002295_abnormal_pulmonary_circulatio2.47314953
22MP0002138_abnormal_hepatobiliary_system2.41791429
23MP0003191_abnormal_cellular_cholesterol2.24296889
24MP0009780_abnormal_chondrocyte_physiolo2.09267211
25MP0003890_abnormal_embryonic-extraembry2.08053991
26MP0005275_abnormal_skin_tensile2.05853062
27MP0002938_white_spotting2.01136297
28MP0000609_abnormal_liver_physiology1.98834268
29MP0009643_abnormal_urine_homeostasis1.98621629
30MP0003279_aneurysm1.92696786
31MP0005319_abnormal_enzyme/_coenzyme1.89197073
32MP0002118_abnormal_lipid_homeostasis1.86649536
33MP0001764_abnormal_homeostasis1.85437495
34MP0003786_premature_aging1.85096281
35MP0003186_abnormal_redox_activity1.82241538
36MP0005584_abnormal_enzyme/coenzyme_acti1.68796607
37MP0000516_abnormal_urinary_system1.67574826
38MP0005367_renal/urinary_system_phenotyp1.67574826
39MP0010234_abnormal_vibrissa_follicle1.66791278
40MP0010386_abnormal_urinary_bladder1.59226605
41MP0003868_abnormal_feces_composition1.57274141
42MP0005508_abnormal_skeleton_morphology1.52005757
43MP0002837_dystrophic_cardiac_calcinosis1.51100176
44MP0000013_abnormal_adipose_tissue1.50065234
45MP0005636_abnormal_mineral_homeostasis1.47782569
46MP0005451_abnormal_body_composition1.46931868
47MP0009379_abnormal_foot_pigmentation1.38778319
48MP0000049_abnormal_middle_ear1.36835932
49MP0003566_abnormal_cell_adhesion1.34383138
50MP0005257_abnormal_intraocular_pressure1.33987092
51MP0010352_gastrointestinal_tract_polyps1.29341500
52MP0006036_abnormal_mitochondrial_physio1.27739884
53MP0005670_abnormal_white_adipose1.27153833
54MP0000598_abnormal_liver_morphology1.24728335
55MP0003283_abnormal_digestive_organ1.23660331
56MP0003656_abnormal_erythrocyte_physiolo1.22723697
57MP0003718_maternal_effect1.22409406
58MP0009697_abnormal_copulation1.22226378
59MP0009764_decreased_sensitivity_to1.20973340
60MP0004133_heterotaxia1.19308466
61MP0008469_abnormal_protein_level1.17269162
62MP0001756_abnormal_urination1.16970534
63MP0001299_abnormal_eye_distance/1.16918825
64MP0005330_cardiomyopathy1.16642176
65MP0001879_abnormal_lymphatic_vessel1.16376172
66MP0009053_abnormal_anal_canal1.15741675
67MP0003950_abnormal_plasma_membrane1.14978152
68MP0000750_abnormal_muscle_regeneration1.14011326
69MP0002136_abnormal_kidney_physiology1.13694603
70MP0005623_abnormal_meninges_morphology1.12534206
71MP0001542_abnormal_bone_strength1.11843466
72MP0000749_muscle_degeneration1.11193274
73MP0003011_delayed_dark_adaptation1.11085596
74MP0003942_abnormal_urinary_system1.10443769
75MP0000762_abnormal_tongue_morphology1.10331349
76MP0001984_abnormal_olfaction1.10158618
77MP0005084_abnormal_gallbladder_morpholo1.09880930
78MP0004043_abnormal_pH_regulation1.07478540
79MP0000751_myopathy1.05706401
80MP0002160_abnormal_reproductive_system1.04971995
81MP0006054_spinal_hemorrhage1.04343692
82MP0001529_abnormal_vocalization1.03059443
83MP0002876_abnormal_thyroid_physiology1.02398137
84MP0009763_increased_sensitivity_to1.01318835
85MP0005058_abnormal_lysosome_morphology0.99805907
86MP0008004_abnormal_stomach_pH0.97748925
87MP0009642_abnormal_blood_homeostasis0.97123779
88MP0005647_abnormal_sex_gland0.96862049
89MP0003123_paternal_imprinting0.95843807
90MP0006072_abnormal_retinal_apoptosis0.95592384
91MP0002060_abnormal_skin_morphology0.94033277
92MP0002282_abnormal_trachea_morphology0.92914526
93MP0005464_abnormal_platelet_physiology0.92197660
94MP0002163_abnormal_gland_morphology0.90371992
95MP0001835_abnormal_antigen_presentation0.90359530
96MP0009250_abnormal_appendicular_skeleto0.90127599
97MP0002254_reproductive_system_inflammat0.89835227
98MP0005220_abnormal_exocrine_pancreas0.89235009
99MP0008058_abnormal_DNA_repair0.86484181
100MP0000685_abnormal_immune_system0.86477752
101MP0003436_decreased_susceptibility_to0.85333894
102MP0001765_abnormal_ion_homeostasis0.84072693
103MP0002736_abnormal_nociception_after0.83730754
104MP0009765_abnormal_xenobiotic_induced0.82855681
105MP0005023_abnormal_wound_healing0.82770518
106MP0003724_increased_susceptibility_to0.82745002
107MP0004215_abnormal_myocardial_fiber0.82641683
108MP0008007_abnormal_cellular_replicative0.81249485
109MP0002233_abnormal_nose_morphology0.78841447
110MP0000163_abnormal_cartilage_morphology0.78070486
111MP0001727_abnormal_embryo_implantation0.77826422
112MP0005376_homeostasis/metabolism_phenot0.77677939
113MP0002108_abnormal_muscle_morphology0.77599697
114MP0004510_myositis0.76574734
115MP0000462_abnormal_digestive_system0.76316925
116MP0005197_abnormal_uvea_morphology0.76020352
117MP0000767_abnormal_smooth_muscle0.75344044
118MP0000534_abnormal_ureter_morphology0.74611193
119MP0001853_heart_inflammation0.74118261
120MP0002078_abnormal_glucose_homeostasis0.73995960
121MP0005408_hypopigmentation0.73690392
122MP0001845_abnormal_inflammatory_respons0.73377670
123MP0003638_abnormal_response/metabolism_0.72784154
124MP0003567_abnormal_fetal_cardiomyocyte0.71512773
125MP0000604_amyloidosis0.70878007
126MP0002928_abnormal_bile_duct0.70840178
127MP0009785_altered_susceptibility_to0.70588656
128MP0002210_abnormal_sex_determination0.69578259
129MP0003937_abnormal_limbs/digits/tail_de0.69039637
130MP0002972_abnormal_cardiac_muscle0.68941380
131MP0001905_abnormal_dopamine_level0.68889583
132MP0000358_abnormal_cell_content/0.68659493
133MP0003755_abnormal_palate_morphology0.68492116
134MP0005535_abnormal_body_temperature0.68220160
135MP0002697_abnormal_eye_size0.67105153
136MP0010368_abnormal_lymphatic_system0.66735745
137MP0008932_abnormal_embryonic_tissue0.66117156
138MP0002909_abnormal_adrenal_gland0.65288747
139MP0000613_abnormal_salivary_gland0.65262430
140MP0005025_abnormal_response_to0.65172940
141MP0005334_abnormal_fat_pad0.64336643
142MP0000639_abnormal_adrenal_gland0.64175330
143MP0006035_abnormal_mitochondrial_morpho0.64141265
144MP0000003_abnormal_adipose_tissue0.64122348
145MP0002177_abnormal_outer_ear0.63851141
146MP0005595_abnormal_vascular_smooth0.63772347
147MP0002971_abnormal_brown_adipose0.63360166
148MP0001293_anophthalmia0.62239701
149MP0001340_abnormal_eyelid_morphology0.62114043
150MP0005666_abnormal_adipose_tissue0.61891902
151MP0005266_abnormal_metabolism0.61714871
152MP0003300_gastrointestinal_ulcer0.61492863
153MP0001958_emphysema0.61444243
154MP0004782_abnormal_surfactant_physiolog0.61063988
155MP0004130_abnormal_muscle_cell0.58550780
156MP0001800_abnormal_humoral_immune0.57806678
157MP0001661_extended_life_span0.56811433
158MP0010155_abnormal_intestine_physiology0.55242632
159MP0004147_increased_porphyrin_level0.54731806
160MP0008873_increased_physiological_sensi0.54428933
161MP0002135_abnormal_kidney_morphology0.53286296
162MP0005387_immune_system_phenotype0.52045968
163MP0001790_abnormal_immune_system0.52045968
164MP0003705_abnormal_hypodermis_morpholog0.51460975
165MP0004264_abnormal_extraembryonic_tissu0.49050830
166MP0000689_abnormal_spleen_morphology0.48422456
167MP0002166_altered_tumor_susceptibility0.47922821
168MP0001873_stomach_inflammation0.46395432
169MP0002419_abnormal_innate_immunity0.46280907
170MP0000230_abnormal_systemic_arterial0.45146083
171MP0009115_abnormal_fat_cell0.44607625
172MP0006082_CNS_inflammation0.44603465
173MP0008872_abnormal_physiological_respon0.44305483
174MP0003953_abnormal_hormone_level0.43847428
175MP0005395_other_phenotype0.43326263
176MP0002723_abnormal_immune_serum0.41310114
177MP0002970_abnormal_white_adipose0.40201803
178MP0000538_abnormal_urinary_bladder0.39625887
179MP0005448_abnormal_energy_balance0.39394223
180MP0000249_abnormal_blood_vessel0.39343034
181MP0005166_decreased_susceptibility_to0.37788950
182MP0004947_skin_inflammation0.37126510
183MP0008874_decreased_physiological_sensi0.36150592

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.55819001
2Intrahepatic cholestasis (HP:0001406)5.65018585
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.62122577
4Deep venous thrombosis (HP:0002625)5.47703219
5Xanthomatosis (HP:0000991)5.05822669
6Hypobetalipoproteinemia (HP:0003563)4.84091342
7Prolonged partial thromboplastin time (HP:0003645)4.72906623
8Hyperglycinuria (HP:0003108)4.57544530
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.50204951
10Hyperammonemia (HP:0001987)4.47513375
11Ketosis (HP:0001946)4.27397766
12Abnormality of aspartate family amino acid metabolism (HP:0010899)4.19092799
13Hyperlipoproteinemia (HP:0010980)4.17637020
14Abnormality of glycine metabolism (HP:0010895)4.16423546
15Abnormality of serine family amino acid metabolism (HP:0010894)4.16423546
16Hyperglycinemia (HP:0002154)4.05618701
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.00777063
18Abnormality of fatty-acid metabolism (HP:0004359)3.91663843
19Acute necrotizing encephalopathy (HP:0006965)3.84874067
20Abnormal mitochondria in muscle tissue (HP:0008316)3.83816962
21Joint hemorrhage (HP:0005261)3.80316801
22Hypoglycemic coma (HP:0001325)3.73006315
23Abnormality of methionine metabolism (HP:0010901)3.71157728
24Complement deficiency (HP:0004431)3.65535140
25Abnormality of pyrimidine metabolism (HP:0004353)3.63471903
26Premature rupture of membranes (HP:0001788)3.63462391
27Gout (HP:0001997)3.63265355
28Hepatocellular necrosis (HP:0001404)3.55304575
29Hypolipoproteinemia (HP:0010981)3.54593842
30Acute encephalopathy (HP:0006846)3.54500773
31Mitochondrial inheritance (HP:0001427)3.48753183
32Abnormality of nucleobase metabolism (HP:0010932)3.46706963
33Progressive macrocephaly (HP:0004481)3.45154248
34Abnormality of the common coagulation pathway (HP:0010990)3.45020140
35Fat malabsorption (HP:0002630)3.42643362
36Abnormality of purine metabolism (HP:0004352)3.38324493
37Generalized aminoaciduria (HP:0002909)3.37917939
38Ketoacidosis (HP:0001993)3.37147349
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36018830
40Congenital, generalized hypertrichosis (HP:0004540)3.34759376
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.24922612
42Delayed CNS myelination (HP:0002188)3.22287540
43Bifid tongue (HP:0010297)3.21653714
44Epidermoid cyst (HP:0200040)3.20804837
45Hyperbilirubinemia (HP:0002904)3.17131706
46Abnormality of dicarboxylic acid metabolism (HP:0010995)3.12734924
47Dicarboxylic aciduria (HP:0003215)3.12734924
48Hypoalphalipoproteinemia (HP:0003233)3.04925289
49Proximal tubulopathy (HP:0000114)3.04281536
50Decreased activity of mitochondrial respiratory chain (HP:0008972)3.01773644
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.01773644
52Abnormality of the intrinsic pathway (HP:0010989)2.97486795
53Metabolic acidosis (HP:0001942)2.96225843
54Conjugated hyperbilirubinemia (HP:0002908)2.95692560
55Increased CSF lactate (HP:0002490)2.95454617
56Abnormality of serum amino acid levels (HP:0003112)2.94296071
57Hypercholesterolemia (HP:0003124)2.87265003
58Lethargy (HP:0001254)2.86818074
59Vascular calcification (HP:0004934)2.76786188
60Median cleft lip (HP:0000161)2.73121470
61Alkalosis (HP:0001948)2.72788539
62Steatorrhea (HP:0002570)2.69439632
63Delayed gross motor development (HP:0002194)2.67495432
64Increased purine levels (HP:0004368)2.65643416
65Hyperuricemia (HP:0002149)2.65643416
66Abnormality of complement system (HP:0005339)2.65179954
67Glycosuria (HP:0003076)2.61989808
68Abnormality of urine glucose concentration (HP:0011016)2.61989808
69Systemic lupus erythematosus (HP:0002725)2.54524191
70Hepatocellular carcinoma (HP:0001402)2.53366489
71Type I transferrin isoform profile (HP:0003642)2.51049235
72Cerebral edema (HP:0002181)2.47679187
73Nuclear cataract (HP:0100018)2.46232192
74Late onset (HP:0003584)2.43940534
75Malnutrition (HP:0004395)2.42805675
76Cardiovascular calcification (HP:0011915)2.40500566
77Vomiting (HP:0002013)2.38497274
78Hypoplastic left heart (HP:0004383)2.34344689
79Irritability (HP:0000737)2.33802962
80Glucose intolerance (HP:0000833)2.31027078
81Hydroxyprolinuria (HP:0003080)2.30852593
82Abnormality of proline metabolism (HP:0010907)2.30852593
83Nausea (HP:0002018)2.30726682
84Spastic diplegia (HP:0001264)2.30425525
85Pancreatitis (HP:0001733)2.30204537
86Methylmalonic acidemia (HP:0002912)2.25665290
87Hypokinesia (HP:0002375)2.24768649
88Respiratory failure (HP:0002878)2.24092442
89Follicular hyperkeratosis (HP:0007502)2.23713476
90Exercise intolerance (HP:0003546)2.23558373
91Spontaneous abortion (HP:0005268)2.23482388
92Myocardial infarction (HP:0001658)2.19481130
93Lactic acidosis (HP:0003128)2.18114618
94Methylmalonic aciduria (HP:0012120)2.16986279
95Neonatal onset (HP:0003623)2.16696702
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15773937
97Abnormal protein N-linked glycosylation (HP:0012347)2.15773937
98Abnormal protein glycosylation (HP:0012346)2.15773937
99Abnormal glycosylation (HP:0012345)2.15773937
100Anophthalmia (HP:0000528)2.10421137
101Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.09347486
102Selective tooth agenesis (HP:0001592)2.06692005
103Increased serum pyruvate (HP:0003542)2.05062248
104Brushfield spots (HP:0001088)2.04959134
105Esophageal varix (HP:0002040)2.04766328
106Gingival bleeding (HP:0000225)2.03178642
107Menorrhagia (HP:0000132)2.02865459
108Sparse eyelashes (HP:0000653)2.02762889
109Rickets (HP:0002748)2.01756100
110Renal cortical cysts (HP:0000803)2.01564896
111Abnormality of glycolysis (HP:0004366)2.01306173
112Hyperinsulinemic hypoglycemia (HP:0000825)2.01106352
113Reduced antithrombin III activity (HP:0001976)1.99774074
114Thrombophlebitis (HP:0004418)1.98760155
115Abnormality of transition element cation homeostasis (HP:0011030)1.98507396
116Abnormality of dentin (HP:0010299)1.98334403
117Hypoglycemic seizures (HP:0002173)1.97576415
118Abnormality of iron homeostasis (HP:0011031)1.96964881
119Enlarged kidneys (HP:0000105)1.96875918
120Elevated hepatic transaminases (HP:0002910)1.96603040
121Redundant skin (HP:0001582)1.96400703
122Sensorimotor neuropathy (HP:0007141)1.95509244
123Facial cleft (HP:0002006)1.94933377
124Abnormal cartilage morphology (HP:0002763)1.94613396
125Renal Fanconi syndrome (HP:0001994)1.94380238
126Entropion (HP:0000621)1.93159470
127Glomerulonephritis (HP:0000099)1.93007968
128Opisthotonus (HP:0002179)1.92957903
129Abnormal enzyme/coenzyme activity (HP:0012379)1.92544259
130Ankle contracture (HP:0006466)1.92361570
131Vertebral compression fractures (HP:0002953)1.91733912
132Nephrolithiasis (HP:0000787)1.91463779
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90314392
134Increased serum lactate (HP:0002151)1.90016879
135Increased hepatocellular lipid droplets (HP:0006565)1.89965534
136Mitral stenosis (HP:0001718)1.89317068
137Reduced subcutaneous adipose tissue (HP:0003758)1.87591217
138Short nail (HP:0001799)1.87482910
139Cutaneous melanoma (HP:0012056)1.87305034
140Cholelithiasis (HP:0001081)1.86701981
141Adrenal hypoplasia (HP:0000835)1.86418450
142Hyperphosphaturia (HP:0003109)1.85919733
143Limb-girdle muscle atrophy (HP:0003797)1.85035028
144Acanthocytosis (HP:0001927)1.84735330
145Abnormal gallbladder morphology (HP:0012437)1.84542139
146Hypoplastic heart (HP:0001961)1.84380361
147Male pseudohermaphroditism (HP:0000037)1.84340044
148Hyperactive renin-angiotensin system (HP:0000841)1.84329661
149Amniotic constriction ring (HP:0009775)1.84032856
150Abnormality of placental membranes (HP:0011409)1.84032856
151Hypokalemic alkalosis (HP:0001949)1.83406295
152Recurrent gram-negative bacterial infections (HP:0005420)1.83287543
153Abnormal lung lobation (HP:0002101)1.82954632
154Hepatic necrosis (HP:0002605)1.82768675
155Hypertriglyceridemia (HP:0002155)1.81589539
156Shoulder girdle muscle weakness (HP:0003547)1.80726543
157Skin nodule (HP:0200036)1.80439420
158True hermaphroditism (HP:0010459)1.80418315
159CNS demyelination (HP:0007305)1.79210414
160Soft skin (HP:0000977)1.78842969
161Patent foramen ovale (HP:0001655)1.77807692
162Congenital ichthyosiform erythroderma (HP:0007431)1.77466875
163Megaloblastic anemia (HP:0001889)1.75840671
164Trismus (HP:0000211)1.75613262
165Vacuolated lymphocytes (HP:0001922)1.73873003
166Abnormality of midbrain morphology (HP:0002418)1.70050013
167Molar tooth sign on MRI (HP:0002419)1.70050013
168Aplasia/Hypoplasia of the tongue (HP:0010295)1.68620418
169Gonadal dysgenesis (HP:0000133)1.67958080
170Meningioma (HP:0002858)1.63719262
171Sclerocornea (HP:0000647)1.63478949
172Abnormal gallbladder physiology (HP:0012438)1.61116213
173Cholecystitis (HP:0001082)1.61116213
174Conjunctival hamartoma (HP:0100780)1.60352305
175Large for gestational age (HP:0001520)1.60335893
176Increased intramyocellular lipid droplets (HP:0012240)1.60326656
177Abnormalities of placenta or umbilical cord (HP:0001194)1.59718006
178Optic disc pallor (HP:0000543)1.56978993
179Hypoplasia of the uterus (HP:0000013)1.56847577
180Pancreatic fibrosis (HP:0100732)1.54708216
181Hamartoma of the eye (HP:0010568)1.54260069
182Rough bone trabeculation (HP:0100670)1.54064897
183Abnormality of the distal phalanges of the toes (HP:0010182)1.50174753
184Down-sloping shoulders (HP:0200021)1.48445644
185Microglossia (HP:0000171)1.48343125
186Exercise-induced muscle cramps (HP:0003710)1.47251720
187Recurrent corneal erosions (HP:0000495)1.47168373
188Abnormality of renal resorption (HP:0011038)1.46665927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.99034705
2PBK4.03492716
3MAP3K123.98225437
4BUB13.90009099
5ERN13.73837775
6FGFR43.25186382
7VRK23.25004565
8MST42.93718161
9MAP4K12.69667465
10TAOK32.67234052
11SIK12.59124574
12TAF12.54784445
13EPHA22.27752119
14FLT32.26194744
15TRIM282.24984299
16NME22.24195270
17NME12.13779789
18WNK42.11286326
19TYK22.05297414
20TNIK2.05136680
21TGFBR22.05011084
22WNK31.99370302
23PKN21.99360408
24KDR1.88265169
25MAP3K91.80325503
26WEE11.75017691
27GRK61.68536487
28TBK11.65284178
29MST1R1.61606865
30ARAF1.59712854
31LMTK21.55415196
32MAP2K31.53785783
33LIMK11.53137149
34MAPK111.47218582
35TIE11.44570945
36TRIB31.43588990
37PNCK1.42700408
38PTK21.40597866
39VRK11.37213710
40PAK41.36571336
41TESK11.35105164
42CSF1R1.34488909
43IRAK31.31356039
44PIK3CG1.30618050
45TGFBR11.30027762
46MAP3K141.28862337
47MAP3K101.28060108
48ZAP701.25102750
49IKBKE1.22789717
50INSRR1.20889090
51BTK1.20232564
52EIF2AK11.20127277
53LATS21.17386124
54OXSR11.14846956
55CDC71.13488943
56KIT1.10338943
57PLK31.10200114
58PTK61.09776755
59BLK1.04825162
60TEC1.04180305
61JAK21.02564522
62LRRK21.02135904
63ABL21.01604222
64NEK90.98238444
65MAP3K110.98214144
66PDK40.95995743
67PDK30.95995743
68ILK0.95049290
69MAP2K60.94435387
70EPHB20.93303107
71NTRK30.91996874
72DAPK10.91810723
73JAK30.90329967
74MAP3K30.89664798
75BRSK10.89124487
76CSNK1G30.88716113
77EEF2K0.87806949
78CSNK1G10.86781159
79EIF2AK20.84766428
80PINK10.83732641
81FGFR20.82638481
82PHKG10.82290036
83PHKG20.82290036
84SYK0.81735108
85ERBB40.80888132
86BMPR1B0.77895312
87MOS0.77662830
88MAP3K70.77329066
89DDR20.76774111
90MAPK40.75237543
91DYRK20.74808771
92STK38L0.74796701
93PRKAA20.74699121
94PLK40.74234493
95NUAK10.73267522
96JAK10.73100845
97CSNK1G20.70508056
98ITK0.70474130
99MAP2K20.70307971
100CAMK2D0.70266705
101DYRK1B0.70187772
102PIM10.68797092
103IKBKB0.68608647
104FGFR10.68326093
105PTK2B0.66558951
106PDGFRA0.66067651
107FRK0.65935767
108CDK40.63925405
109CDK60.63505922
110ADRBK10.63100298
111CSK0.63084186
112TXK0.62652585
113STK380.62566029
114DMPK0.61358973
115CSNK1A1L0.61090598
116STK160.60396201
117LYN0.60164018
118STK100.59664799
119ACVR1B0.59571408
120PLK10.59284002
121DAPK30.59260479
122TSSK60.57278751
123NTRK10.57258660
124MYLK0.56783709
125RPS6KA40.54929647
126PRKD30.54654041
127CAMK2G0.54068452
128NLK0.49136331
129TAOK20.48714700
130PRKCE0.48581447
131MAPKAPK30.48565799
132PRKG20.48504230
133DAPK20.48178159
134TTK0.47032399
135CSNK2A20.45778049
136MAPK120.45383449
137MAPK150.45155514
138MET0.44509554
139MKNK20.43296904
140AURKA0.43183552
141PDK20.41898493
142CAMK2B0.41878706
143PAK10.41855735
144PIM20.41725881
145EPHB10.41655912
146PRKCQ0.41465958
147PDK10.41171661
148CDK70.40950026
149CHUK0.40582823
150CHEK20.40340690
151PRKACG0.39583434
152MAP2K40.39562548
153EIF2AK30.39561871
154STK390.39397023
155AURKB0.38695944
156PAK20.38344204
157GSK3A0.37334014
158MAP3K80.37186399
159NEK10.37100243
160DYRK30.36618311
161SGK30.35024872
162GRK50.34979948
163ROCK10.33527564
164ADRBK20.33428963
165CSNK2A10.32995355
166PRKAA10.32011880
167LCK0.31563548
168PRKCZ0.31529655
169RPS6KB20.31520522
170GRK10.31016916
171STK40.27549984
172IGF1R0.27491397
173PRKCD0.26968326

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.19143203
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.81628339
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.54481867
4Oxidative phosphorylation_Homo sapiens_hsa001903.36916084
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87973063
6Parkinsons disease_Homo sapiens_hsa050122.84282604
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73590034
8Nitrogen metabolism_Homo sapiens_hsa009102.68626593
9Tryptophan metabolism_Homo sapiens_hsa003802.67760745
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66009763
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.61487418
12Arginine biosynthesis_Homo sapiens_hsa002202.60006655
13Fatty acid degradation_Homo sapiens_hsa000712.58882781
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50177643
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41532732
16Propanoate metabolism_Homo sapiens_hsa006402.28887621
17Peroxisome_Homo sapiens_hsa041462.23500027
18Butanoate metabolism_Homo sapiens_hsa006502.19492236
19Huntingtons disease_Homo sapiens_hsa050162.14146859
20Complement and coagulation cascades_Homo sapiens_hsa046102.11039844
21* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05642917
22Mismatch repair_Homo sapiens_hsa034302.02485083
23RNA polymerase_Homo sapiens_hsa030201.98497658
24Alzheimers disease_Homo sapiens_hsa050101.95203502
25* Chemical carcinogenesis_Homo sapiens_hsa052041.87939303
26Homologous recombination_Homo sapiens_hsa034401.86375922
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.84150771
28PPAR signaling pathway_Homo sapiens_hsa033201.83028121
29Histidine metabolism_Homo sapiens_hsa003401.83018972
30* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82346237
31Selenocompound metabolism_Homo sapiens_hsa004501.81955788
32beta-Alanine metabolism_Homo sapiens_hsa004101.80771470
33Caffeine metabolism_Homo sapiens_hsa002321.76572241
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76026326
35Fatty acid metabolism_Homo sapiens_hsa012121.74323088
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.73404183
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.70901140
38Base excision repair_Homo sapiens_hsa034101.67889855
39Pyruvate metabolism_Homo sapiens_hsa006201.65586787
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64825059
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64740204
42Folate biosynthesis_Homo sapiens_hsa007901.55175611
43Retinol metabolism_Homo sapiens_hsa008301.52854056
44DNA replication_Homo sapiens_hsa030301.51435496
45Phenylalanine metabolism_Homo sapiens_hsa003601.50083377
46Nucleotide excision repair_Homo sapiens_hsa034201.45967816
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44030902
48Sulfur metabolism_Homo sapiens_hsa009201.43818875
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.40330977
50Bile secretion_Homo sapiens_hsa049761.39387582
51Staphylococcus aureus infection_Homo sapiens_hsa051501.39049995
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36988664
53Carbon metabolism_Homo sapiens_hsa012001.36525268
54Biosynthesis of amino acids_Homo sapiens_hsa012301.32115074
55Tyrosine metabolism_Homo sapiens_hsa003501.29851056
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29318733
57Starch and sucrose metabolism_Homo sapiens_hsa005001.28964146
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27445749
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22176020
60Sulfur relay system_Homo sapiens_hsa041221.21326812
61Basal transcription factors_Homo sapiens_hsa030221.18319211
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17891324
63Fat digestion and absorption_Homo sapiens_hsa049751.14051355
64Cardiac muscle contraction_Homo sapiens_hsa042601.13787746
65Fatty acid elongation_Homo sapiens_hsa000621.12266535
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11449758
67Arginine and proline metabolism_Homo sapiens_hsa003301.09114531
68ABC transporters_Homo sapiens_hsa020101.09017879
69Vitamin digestion and absorption_Homo sapiens_hsa049771.08121101
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06097766
71Maturity onset diabetes of the young_Homo sapiens_hsa049501.01500566
72One carbon pool by folate_Homo sapiens_hsa006701.00821893
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99514649
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97570073
75Vibrio cholerae infection_Homo sapiens_hsa051100.96213572
76Pentose phosphate pathway_Homo sapiens_hsa000300.95810139
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94194646
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92200495
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91415451
80* Glutathione metabolism_Homo sapiens_hsa004800.91357750
81Fanconi anemia pathway_Homo sapiens_hsa034600.87100272
82Purine metabolism_Homo sapiens_hsa002300.84344895
83Glycerolipid metabolism_Homo sapiens_hsa005610.84173920
84Hedgehog signaling pathway_Homo sapiens_hsa043400.83285520
85N-Glycan biosynthesis_Homo sapiens_hsa005100.82025069
86Lysine degradation_Homo sapiens_hsa003100.81650486
87TGF-beta signaling pathway_Homo sapiens_hsa043500.78572711
88Basal cell carcinoma_Homo sapiens_hsa052170.78466416
89Steroid biosynthesis_Homo sapiens_hsa001000.72620875
90ECM-receptor interaction_Homo sapiens_hsa045120.69920614
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67147139
92Hippo signaling pathway_Homo sapiens_hsa043900.60320908
93Fructose and mannose metabolism_Homo sapiens_hsa000510.58343381
94p53 signaling pathway_Homo sapiens_hsa041150.58282753
95Vitamin B6 metabolism_Homo sapiens_hsa007500.56746793
96Metabolic pathways_Homo sapiens_hsa011000.56543259
97Collecting duct acid secretion_Homo sapiens_hsa049660.55460932
98RNA degradation_Homo sapiens_hsa030180.54206482
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54126800
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48818166
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48323425
102RNA transport_Homo sapiens_hsa030130.47739650
103Spliceosome_Homo sapiens_hsa030400.44207307
104Galactose metabolism_Homo sapiens_hsa000520.40843199
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37169609
106Tight junction_Homo sapiens_hsa045300.36061203
107Non-homologous end-joining_Homo sapiens_hsa034500.33807358
108Oocyte meiosis_Homo sapiens_hsa041140.32776680
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31252376
110Linoleic acid metabolism_Homo sapiens_hsa005910.31232249
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31068075
112Other glycan degradation_Homo sapiens_hsa005110.21977907
113Fatty acid biosynthesis_Homo sapiens_hsa000610.21635756
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19862461
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.18766818
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.16721248
117Insulin resistance_Homo sapiens_hsa049310.16332094
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15698748
119Primary immunodeficiency_Homo sapiens_hsa053400.12472752
120Pyrimidine metabolism_Homo sapiens_hsa002400.11135200
121Arachidonic acid metabolism_Homo sapiens_hsa005900.09744259
122Ribosome_Homo sapiens_hsa030100.09439058
123Renin-angiotensin system_Homo sapiens_hsa046140.07538944
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.04422994
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.01063309
126Antigen processing and presentation_Homo sapiens_hsa04612-0.1299671
127Hepatitis C_Homo sapiens_hsa05160-0.1297370
128Mineral absorption_Homo sapiens_hsa04978-0.1265073
129Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1253205
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1226983
131Lysosome_Homo sapiens_hsa04142-0.1222209
132Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1160927
133Legionellosis_Homo sapiens_hsa05134-0.1055805
134Prion diseases_Homo sapiens_hsa05020-0.1030796
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0906960
136Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0696376
137Protein export_Homo sapiens_hsa03060-0.0681924
138AMPK signaling pathway_Homo sapiens_hsa04152-0.0536431
139Protein digestion and absorption_Homo sapiens_hsa04974-0.0202814
140Glucagon signaling pathway_Homo sapiens_hsa04922-0.0077364

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