GSTM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.71551523
2L-phenylalanine catabolic process (GO:0006559)6.71551523
3L-phenylalanine metabolic process (GO:0006558)6.55238829
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.55238829
5aromatic amino acid family catabolic process (GO:0009074)6.42415591
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.25145154
7tryptophan catabolic process (GO:0006569)6.16331577
8indole-containing compound catabolic process (GO:0042436)6.16331577
9indolalkylamine catabolic process (GO:0046218)6.16331577
10kynurenine metabolic process (GO:0070189)5.73286213
11tryptophan metabolic process (GO:0006568)5.67771087
12bile acid biosynthetic process (GO:0006699)5.50852359
13urea metabolic process (GO:0019627)5.50696226
14urea cycle (GO:0000050)5.50696226
15glyoxylate metabolic process (GO:0046487)5.50251237
16high-density lipoprotein particle remodeling (GO:0034375)5.43177468
17cellular glucuronidation (GO:0052695)5.30488754
18flavonoid metabolic process (GO:0009812)5.23446160
19regulation of cholesterol esterification (GO:0010872)5.21929953
20negative regulation of fibrinolysis (GO:0051918)5.21802010
21drug catabolic process (GO:0042737)5.21459702
22regulation of triglyceride catabolic process (GO:0010896)5.20082285
23sulfur amino acid catabolic process (GO:0000098)5.07866861
24cysteine metabolic process (GO:0006534)5.07641418
25alpha-linolenic acid metabolic process (GO:0036109)5.06024217
26nitrogen cycle metabolic process (GO:0071941)5.02385360
27phospholipid efflux (GO:0033700)5.01044794
28peptidyl-glutamic acid carboxylation (GO:0017187)4.98526490
29protein carboxylation (GO:0018214)4.98526490
30regulation of protein activation cascade (GO:2000257)4.88733807
31protein-lipid complex remodeling (GO:0034368)4.87428485
32macromolecular complex remodeling (GO:0034367)4.87428485
33plasma lipoprotein particle remodeling (GO:0034369)4.87428485
34regulation of fibrinolysis (GO:0051917)4.86819503
35bile acid metabolic process (GO:0008206)4.83374428
36complement activation, alternative pathway (GO:0006957)4.79402162
37reverse cholesterol transport (GO:0043691)4.78353678
38negative regulation of cholesterol transport (GO:0032375)4.76564178
39negative regulation of sterol transport (GO:0032372)4.76564178
40glucuronate metabolic process (GO:0019585)4.74174862
41uronic acid metabolic process (GO:0006063)4.74174862
42homocysteine metabolic process (GO:0050667)4.65302259
43serine family amino acid catabolic process (GO:0009071)4.63332529
44intestinal cholesterol absorption (GO:0030299)4.63300288
45aromatic amino acid family metabolic process (GO:0009072)4.62717564
46cholesterol efflux (GO:0033344)4.61043356
47very-low-density lipoprotein particle assembly (GO:0034379)4.60555954
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.60484830
49plasma lipoprotein particle assembly (GO:0034377)4.58360281
50regulation of complement activation (GO:0030449)4.55500723
51* response to nitrosative stress (GO:0051409)4.54433481
52bile acid and bile salt transport (GO:0015721)4.52929579
53* xenobiotic catabolic process (GO:0042178)4.51349009
54heme transport (GO:0015886)4.48709904
55* benzene-containing compound metabolic process (GO:0042537)4.44896998
56exogenous drug catabolic process (GO:0042738)4.43223386
57triglyceride homeostasis (GO:0070328)4.42824345
58acylglycerol homeostasis (GO:0055090)4.42824345
59plasma lipoprotein particle clearance (GO:0034381)4.34103813
60indolalkylamine metabolic process (GO:0006586)4.24480273
61amino-acid betaine metabolic process (GO:0006577)4.23298643
62alpha-amino acid catabolic process (GO:1901606)4.22652678
63amine catabolic process (GO:0009310)4.17722791
64cellular biogenic amine catabolic process (GO:0042402)4.17722791
65epoxygenase P450 pathway (GO:0019373)4.16830096
66protein-lipid complex assembly (GO:0065005)4.14728334
67* glutathione derivative biosynthetic process (GO:1901687)4.14693726
68* glutathione derivative metabolic process (GO:1901685)4.14693726
69lysine catabolic process (GO:0006554)4.06510157
70lysine metabolic process (GO:0006553)4.06510157
71intestinal absorption (GO:0050892)4.04639495
72cellular ketone body metabolic process (GO:0046950)4.02933713
73positive regulation of triglyceride lipase activity (GO:0061365)4.02876941
74positive regulation of lipoprotein lipase activity (GO:0051006)4.02876941
75cholesterol homeostasis (GO:0042632)4.01959136
76glycine metabolic process (GO:0006544)4.00539582
77tyrosine metabolic process (GO:0006570)4.00258837
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96170471
79sterol homeostasis (GO:0055092)3.95382153
80serine family amino acid metabolic process (GO:0009069)3.94562910
81glutamate metabolic process (GO:0006536)3.89770004
82cellular amino acid catabolic process (GO:0009063)3.89190512
83lipoprotein metabolic process (GO:0042157)3.87628305
84serine family amino acid biosynthetic process (GO:0009070)3.83960341
85drug metabolic process (GO:0017144)3.83605742
86plasma lipoprotein particle organization (GO:0071827)3.82949710
87regulation of bile acid biosynthetic process (GO:0070857)3.79844516
88low-density lipoprotein particle remodeling (GO:0034374)3.79478384
89imidazole-containing compound metabolic process (GO:0052803)3.79323950
90positive regulation of lipid catabolic process (GO:0050996)3.78656745
91aldehyde catabolic process (GO:0046185)3.77387889
92regulation of cholesterol homeostasis (GO:2000188)3.74960516
93cellular modified amino acid catabolic process (GO:0042219)3.73102895
94fibrinolysis (GO:0042730)3.72418159
95negative regulation of lipase activity (GO:0060192)3.67012895
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.66487733
97arginine metabolic process (GO:0006525)3.65751331
98ethanol oxidation (GO:0006069)3.63493133
99protein-lipid complex subunit organization (GO:0071825)3.62480229
100dicarboxylic acid biosynthetic process (GO:0043650)3.62185382
101phospholipid homeostasis (GO:0055091)3.58943483
102acute-phase response (GO:0006953)3.57424963
103water-soluble vitamin biosynthetic process (GO:0042364)3.51882570
104ATP synthesis coupled proton transport (GO:0015986)3.39890420
105energy coupled proton transport, down electrochemical gradient (GO:0015985)3.39890420
106behavioral response to nicotine (GO:0035095)3.33263569
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19010269
108protein complex biogenesis (GO:0070271)3.14429590
109electron transport chain (GO:0022900)3.07528347
110respiratory electron transport chain (GO:0022904)3.05725814
111prostate gland growth (GO:0060736)3.02136296
112positive regulation of meiosis (GO:0045836)2.94139201
113gamma-aminobutyric acid transport (GO:0015812)2.90056554
114positive regulation of meiotic cell cycle (GO:0051446)2.79277365
115mitochondrial respiratory chain complex assembly (GO:0033108)2.76603602
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73559866
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.68570237
118NADH dehydrogenase complex assembly (GO:0010257)2.68570237
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.68570237
120mannosylation (GO:0097502)2.60942650
121positive regulation of mitochondrial fission (GO:0090141)2.58794774
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56979381
123serotonin metabolic process (GO:0042428)2.55718030
124protein localization to cilium (GO:0061512)2.50733045
125hydrogen ion transmembrane transport (GO:1902600)2.49152366
126protein polyglutamylation (GO:0018095)2.48684290
127transmission of nerve impulse (GO:0019226)2.45643873
128negative regulation of response to food (GO:0032096)2.44581363
129negative regulation of appetite (GO:0032099)2.44581363
130regulation of glomerulus development (GO:0090192)2.44099915
131establishment of protein localization to mitochondrial membrane (GO:0090151)2.42120416
132positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.41858685
133regulation of action potential (GO:0098900)2.40119821
134primary amino compound metabolic process (GO:1901160)2.39580153
135proton transport (GO:0015992)2.38459559
136response to pheromone (GO:0019236)2.38245714
137hydrogen transport (GO:0006818)2.34823386
138regulation of cell proliferation involved in kidney development (GO:1901722)2.32742976
139startle response (GO:0001964)2.30747392
140ketone body metabolic process (GO:1902224)2.30343701
141preassembly of GPI anchor in ER membrane (GO:0016254)2.28163875
142presynaptic membrane assembly (GO:0097105)2.28144007
143postsynaptic membrane organization (GO:0001941)2.27354734
144regulation of hexokinase activity (GO:1903299)2.26115245
145regulation of glucokinase activity (GO:0033131)2.26115245
146pyrimidine nucleobase catabolic process (GO:0006208)2.25270404
147neuron cell-cell adhesion (GO:0007158)2.24070792
148respiratory chain complex IV assembly (GO:0008535)2.23818572
149limb bud formation (GO:0060174)2.23455811
150peroxisome fission (GO:0016559)2.22096638
151platelet dense granule organization (GO:0060155)2.20100006
152ATP biosynthetic process (GO:0006754)2.19025530
153positive regulation of actin filament depolymerization (GO:0030836)2.18918841
154regulation of short-term neuronal synaptic plasticity (GO:0048172)2.14893220
155regulation of calcium ion-dependent exocytosis (GO:0017158)2.14838449
156purine nucleoside triphosphate biosynthetic process (GO:0009145)2.14258548
157norepinephrine metabolic process (GO:0042415)2.13211656
158neuromuscular synaptic transmission (GO:0007274)2.13208169
159neuronal action potential propagation (GO:0019227)2.13138187
160nonmotile primary cilium assembly (GO:0035058)2.13083222
161auditory behavior (GO:0031223)2.12164845
162GPI anchor metabolic process (GO:0006505)2.12033129
163branched-chain amino acid catabolic process (GO:0009083)2.11990017
164calcium ion-dependent exocytosis (GO:0017156)2.10680303
165membrane depolarization during action potential (GO:0086010)2.10654829
166aggressive behavior (GO:0002118)2.09606547
167synapse assembly (GO:0007416)2.09085584
168axonal fasciculation (GO:0007413)2.08645676
169neuronal action potential (GO:0019228)2.07600708
170C4-dicarboxylate transport (GO:0015740)2.07112787
171purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.07019893
172L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.06794069
173positive regulation of glomerulus development (GO:0090193)2.05890719
174presynaptic membrane organization (GO:0097090)2.05401966
175nucleobase catabolic process (GO:0046113)2.04927378
176artery smooth muscle contraction (GO:0014824)2.04666820
177intraciliary transport (GO:0042073)2.04359733
178retinal ganglion cell axon guidance (GO:0031290)2.04094828
179negative regulation of hormone biosynthetic process (GO:0032353)2.03922995
180cellular potassium ion homeostasis (GO:0030007)2.02349841
181reflex (GO:0060004)2.02168603
182regulation of membrane repolarization (GO:0060306)2.02135653
183anterograde axon cargo transport (GO:0008089)2.01313113
184cornea development in camera-type eye (GO:0061303)2.00198981
185detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)1.98551737
186cardiac right ventricle morphogenesis (GO:0003215)1.98087738
187G-protein coupled glutamate receptor signaling pathway (GO:0007216)1.97990883
188cilium morphogenesis (GO:0060271)1.97326738
189ATP hydrolysis coupled proton transport (GO:0015991)1.96522101
190energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)1.96522101
191cytochrome complex assembly (GO:0017004)1.96335607
192purine ribonucleoside bisphosphate metabolic process (GO:0034035)1.95886219
1933-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)1.95886219
194indole-containing compound metabolic process (GO:0042430)1.95864422
195protein localization to synapse (GO:0035418)1.95824836
196C-terminal protein lipidation (GO:0006501)1.95654004
197negative regulation of transcription regulatory region DNA binding (GO:2000678)1.95244175
198epithelial cell maturation (GO:0002070)1.95095882
199chaperone-mediated protein transport (GO:0072321)1.94870579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.95025074
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.04080963
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.97458430
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.19466685
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.08998171
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83423505
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.75240766
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.60368329
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.63880083
10GBX2_23144817_ChIP-Seq_PC3_Human3.25019853
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.13485937
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.66372476
13EZH2_22144423_ChIP-Seq_EOC_Human2.62548565
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39479623
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31743305
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.25073238
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21484471
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11334095
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10002181
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.09163152
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06767026
22ZNF274_21170338_ChIP-Seq_K562_Hela2.02178265
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01778090
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00390387
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.00349237
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5152040
27IGF1R_20145208_ChIP-Seq_DFB_Human1.97613497
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.96649099
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89238092
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85871207
31FUS_26573619_Chip-Seq_HEK293_Human1.77893841
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77060705
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76323591
34GATA1_22025678_ChIP-Seq_K562_Human1.75865946
35TAF15_26573619_Chip-Seq_HEK293_Human1.75081945
36CLOCK_20551151_ChIP-Seq_293T_Human1.73682456
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72705549
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70968459
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69349949
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68570128
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64466810
42VDR_22108803_ChIP-Seq_LS180_Human1.63792459
43ER_23166858_ChIP-Seq_MCF-7_Human1.63076146
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.60546874
45RNF2_27304074_Chip-Seq_NSC_Mouse1.58599112
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57900046
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56639400
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55444098
49P300_19829295_ChIP-Seq_ESCs_Human1.52197377
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.50561658
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49506568
52* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48977616
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.48164628
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.47299414
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46770006
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46770006
57HNF4A_19822575_ChIP-Seq_HepG2_Human1.46346292
58REST_21632747_ChIP-Seq_MESCs_Mouse1.45503813
59SMAD4_21799915_ChIP-Seq_A2780_Human1.45312152
60HTT_18923047_ChIP-ChIP_STHdh_Human1.45042330
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42563938
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42271043
63EWS_26573619_Chip-Seq_HEK293_Human1.41990890
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39659316
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39503810
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39138532
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38117216
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37940583
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.36671755
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36434155
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35595823
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35429583
73AR_25329375_ChIP-Seq_VCAP_Human1.34445442
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34398500
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33584402
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32630621
77* AHR_22903824_ChIP-Seq_MCF-7_Human1.32196747
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.30656037
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30117295
80* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29980458
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24848489
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.23085005
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20834077
84TP53_22573176_ChIP-Seq_HFKS_Human1.20345167
85* GATA4_25053715_ChIP-Seq_YYC3_Human1.17367818
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16319376
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16122246
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14326678
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.13413237
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13337161
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13030530
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12555170
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.11840716
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11565565
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.10260930
96RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09191143
97* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05283244
98CBP_20019798_ChIP-Seq_JUKART_Human1.04921611
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04921611
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04791371
101STAT3_23295773_ChIP-Seq_U87_Human1.04589008
102ZNF263_19887448_ChIP-Seq_K562_Human1.04004411
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03853684
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03453434
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02044112
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00933329
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00869865
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00184723
109RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99805374
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96759890
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96471675
112TCF4_23295773_ChIP-Seq_U87_Human0.96253442
113TP53_20018659_ChIP-ChIP_R1E_Mouse0.96202791
114NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95730354
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94690649
116KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94227684
117SOX2_19829295_ChIP-Seq_ESCs_Human0.93759329
118NANOG_19829295_ChIP-Seq_ESCs_Human0.93759329
119* ESR2_21235772_ChIP-Seq_MCF-7_Human0.92953429
120TP63_17297297_ChIP-ChIP_HaCaT_Human0.92709348
121TP53_18474530_ChIP-ChIP_U2OS_Human0.92383000
122TCF4_22108803_ChIP-Seq_LS180_Human0.90233533
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89887562
124SRF_21415370_ChIP-Seq_HL-1_Mouse0.89125146
125HOXB7_26014856_ChIP-Seq_BT474_Human0.88757780
126* SMAD4_21741376_ChIP-Seq_EPCs_Human0.88250783
127JUN_21703547_ChIP-Seq_K562_Human0.87831925
128TRIM28_21343339_ChIP-Seq_HEK293_Human0.86898239
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83435494
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82546922
131* GATA6_25053715_ChIP-Seq_YYC3_Human0.81781536
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80672245
133Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80401092
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80335228
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79821056
136RARA_24833708_ChIP-Seq_LIVER_Mouse0.78815228
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78181162
138KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75335399
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73737943
140SOX2_20726797_ChIP-Seq_SW620_Human0.73208370
141IRF8_22096565_ChIP-ChIP_GC-B_Human0.72864703
142* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72629113
143* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72629113
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70790866
145STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.69336857
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68779917
147PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67530434
148LXR_22292898_ChIP-Seq_THP-1_Human0.65327517
149NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65135405
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65067698
151BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64561017
152RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61518355
153SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60925691
154ESR1_21235772_ChIP-Seq_MCF-7_Human0.59885095
155PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.58499782
156STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55810093
157FOXO3_23340844_ChIP-Seq_DLD1_Human0.55395928
158POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.55201722
159BCAT_22108803_ChIP-Seq_LS180_Human0.54832702
160GATA2_19941826_ChIP-Seq_K562_Human0.53911278
161FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.53674153
162FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52746398
163EGR1_19032775_ChIP-ChIP_M12_Human0.52282086
164FOXA1_25552417_ChIP-Seq_VCAP_Human0.52053415
165* MYC_19915707_ChIP-ChIP_AK7_Human0.50290023
166* RACK7_27058665_Chip-Seq_MCF-7_Human0.50129712
167MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.49894375
168STAT1_17558387_ChIP-Seq_HELA_Human0.49613523
169FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49601086
170* CEBPB_22108803_ChIP-Seq_LS180_Human0.49479222
171* RARB_24833708_ChIP-Seq_LIVER_Mouse0.49144326
172FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48523795
173ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.48503093
174GATA1_19941826_ChIP-Seq_K562_Human0.47353413
175PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46613348
176* SRY_22984422_ChIP-ChIP_TESTIS_Rat0.46154385
177ESR1_20079471_ChIP-ChIP_T-47D_Human0.45860127
178ERG_21242973_ChIP-ChIP_JURKAT_Human0.45779053
179* SPI1_26923725_Chip-Seq_HPCs_Mouse0.43652434
180ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.42851030
181ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.42458368
182AR_20517297_ChIP-Seq_VCAP_Human0.41149880
183GATA3_24758297_ChIP-Seq_MCF-7_Human0.40592853
184SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40259121
185ESET_19884257_ChIP-Seq_ESCs_Mouse0.40207011
186NCOR_22424771_ChIP-Seq_293T_Human0.39436726
187P53_21459846_ChIP-Seq_SAOS-2_Human0.39432827
188TAF2_19829295_ChIP-Seq_ESCs_Human0.39180622
189EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.38866867
190GATA1_19941827_ChIP-Seq_MEL_Mouse0.38846790
191TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.38829887
192CBP_21632823_ChIP-Seq_H3396_Human0.37619643
193* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.36257485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.44715776
2MP0005360_urolithiasis8.17353759
3MP0005085_abnormal_gallbladder_physiolo6.29275963
4MP0008875_abnormal_xenobiotic_pharmacok6.10595322
5MP0005365_abnormal_bile_salt6.01957274
6MP0003252_abnormal_bile_duct4.08162198
7MP0003806_abnormal_nucleotide_metabolis3.89088094
8MP0010329_abnormal_lipoprotein_level3.48151819
9MP0009840_abnormal_foam_cell3.46422506
10MP0001666_abnormal_nutrient_absorption3.26858866
11MP0005646_abnormal_pituitary_gland2.77608048
12MP0009780_abnormal_chondrocyte_physiolo2.75029133
13MP0005083_abnormal_biliary_tract2.57576430
14MP0002837_dystrophic_cardiac_calcinosis2.43461547
15MP0005332_abnormal_amino_acid2.41616975
16MP0003880_abnormal_central_pattern2.40237591
17MP0010386_abnormal_urinary_bladder2.37374932
18MP0001968_abnormal_touch/_nociception2.35270473
19MP0003195_calcinosis2.25794311
20MP0002736_abnormal_nociception_after2.21494743
21MP0004019_abnormal_vitamin_homeostasis2.17586522
22MP0003191_abnormal_cellular_cholesterol2.10819961
23MP0004270_analgesia2.04659419
24MP0009046_muscle_twitch2.02545841
25MP0000609_abnormal_liver_physiology2.02495178
26MP0002118_abnormal_lipid_homeostasis1.97245319
27MP0002102_abnormal_ear_morphology1.83473228
28MP0002272_abnormal_nervous_system1.81763679
29MP0009745_abnormal_behavioral_response1.80302633
30MP0002909_abnormal_adrenal_gland1.78308670
31MP0003868_abnormal_feces_composition1.76712177
32MP0005319_abnormal_enzyme/_coenzyme1.74351303
33MP0002138_abnormal_hepatobiliary_system1.69914400
34MP0005379_endocrine/exocrine_gland_phen1.68200493
35MP0005551_abnormal_eye_electrophysiolog1.65704814
36MP0003122_maternal_imprinting1.64614352
37MP0002734_abnormal_mechanical_nocicepti1.62376600
38MP0002160_abnormal_reproductive_system1.59213926
39MP0009697_abnormal_copulation1.57030312
40MP0005423_abnormal_somatic_nervous1.56573036
41MP0002064_seizures1.55195554
42MP0006072_abnormal_retinal_apoptosis1.54896075
43MP0006276_abnormal_autonomic_nervous1.50376652
44MP0000427_abnormal_hair_cycle1.45442183
45MP0004145_abnormal_muscle_electrophysio1.44749024
46MP0004885_abnormal_endolymph1.44261696
47MP0003635_abnormal_synaptic_transmissio1.42793354
48MP0001764_abnormal_homeostasis1.42365405
49MP0001486_abnormal_startle_reflex1.40491059
50MP0002572_abnormal_emotion/affect_behav1.40019736
51MP0001529_abnormal_vocalization1.39580482
52MP0002557_abnormal_social/conspecific_i1.38743914
53MP0005367_renal/urinary_system_phenotyp1.38522028
54MP0000516_abnormal_urinary_system1.38522028
55MP0002735_abnormal_chemical_nociception1.38469365
56MP0000631_abnormal_neuroendocrine_gland1.38190826
57MP0001984_abnormal_olfaction1.37115981
58MP0005584_abnormal_enzyme/coenzyme_acti1.35882848
59MP0001905_abnormal_dopamine_level1.35651334
60MP0009643_abnormal_urine_homeostasis1.28749560
61MP0003283_abnormal_digestive_organ1.26555834
62MP0003011_delayed_dark_adaptation1.26469993
63MP0005389_reproductive_system_phenotype1.25952554
64MP0001970_abnormal_pain_threshold1.22726288
65MP0003879_abnormal_hair_cell1.22437324
66MP0004859_abnormal_synaptic_plasticity1.21023241
67MP0002184_abnormal_innervation1.20587897
68MP0004142_abnormal_muscle_tone1.20268540
69MP0003705_abnormal_hypodermis_morpholog1.19462987
70MP0002638_abnormal_pupillary_reflex1.13845876
71MP0001485_abnormal_pinna_reflex1.13698480
72MP0002063_abnormal_learning/memory/cond1.13239227
73MP0005253_abnormal_eye_physiology1.13003242
74MP0005187_abnormal_penis_morphology1.12324206
75MP0001919_abnormal_reproductive_system1.11743343
76MP0002254_reproductive_system_inflammat1.10307855
77MP0002938_white_spotting1.10155605
78MP0000013_abnormal_adipose_tissue1.10147407
79MP0000598_abnormal_liver_morphology1.06708022
80MP0001346_abnormal_lacrimal_gland1.05613447
81MP0003186_abnormal_redox_activity1.02326431
82MP0002733_abnormal_thermal_nociception1.01884819
83MP0004215_abnormal_myocardial_fiber1.00810061
84MP0000604_amyloidosis1.00309628
85MP0000534_abnormal_ureter_morphology0.99474794
86MP0005636_abnormal_mineral_homeostasis0.98843778
87MP0002067_abnormal_sensory_capabilities0.98818982
88MP0003656_abnormal_erythrocyte_physiolo0.98729825
89MP0000026_abnormal_inner_ear0.97865029
90MP0005410_abnormal_fertilization0.97144904
91MP0001440_abnormal_grooming_behavior0.96921984
92MP0004133_heterotaxia0.96435351
93MP0004742_abnormal_vestibular_system0.94666129
94MP0000383_abnormal_hair_follicle0.94595148
95MP0003938_abnormal_ear_development0.93772930
96MP0005645_abnormal_hypothalamus_physiol0.93480636
97MP0000778_abnormal_nervous_system0.92616859
98MP0001963_abnormal_hearing_physiology0.90769812
99MP0009763_increased_sensitivity_to0.90350758
100MP0005451_abnormal_body_composition0.89059097
101MP0009764_decreased_sensitivity_to0.88225501
102MP0004085_abnormal_heartbeat0.87814141
103MP0004924_abnormal_behavior0.87746539
104MP0005386_behavior/neurological_phenoty0.87746539
105MP0005503_abnormal_tendon_morphology0.87356323
106MP0002822_catalepsy0.87133347
107MP0002090_abnormal_vision0.86897882
108MP0003137_abnormal_impulse_conducting0.85993351
109MP0001944_abnormal_pancreas_morphology0.85849369
110MP0003942_abnormal_urinary_system0.84836436
111MP0008469_abnormal_protein_level0.83625510
112MP0005084_abnormal_gallbladder_morpholo0.83126045
113MP0009642_abnormal_blood_homeostasis0.82856303
114MP0000049_abnormal_middle_ear0.81929075
115MP0002295_abnormal_pulmonary_circulatio0.80904842
116MP0001501_abnormal_sleep_pattern0.80791754
117MP0005408_hypopigmentation0.80591485
118MP0002282_abnormal_trachea_morphology0.80178017
119MP0009765_abnormal_xenobiotic_induced0.80175399
120MP0002751_abnormal_autonomic_nervous0.79183232
121MP0008775_abnormal_heart_ventricle0.79123556
122MP0009053_abnormal_anal_canal0.79090889
123MP0000647_abnormal_sebaceous_gland0.78976110
124MP0005647_abnormal_sex_gland0.78838200
125MP0009250_abnormal_appendicular_skeleto0.78580395
126MP0002928_abnormal_bile_duct0.77110497
127MP0008789_abnormal_olfactory_epithelium0.76859950
128MP0005376_homeostasis/metabolism_phenot0.75870637
129MP0004264_abnormal_extraembryonic_tissu0.74798335
130MP0010234_abnormal_vibrissa_follicle0.74387006
131MP0008872_abnormal_physiological_respon0.69471146
132MP0002078_abnormal_glucose_homeostasis0.68340146
133MP0005266_abnormal_metabolism0.67659566
134MP0003329_amyloid_beta_deposits0.67385114
135MP0002876_abnormal_thyroid_physiology0.66673660
136MP0003718_maternal_effect0.65596268
137MP0006036_abnormal_mitochondrial_physio0.65342618
138MP0005448_abnormal_energy_balance0.63837414
139MP0003690_abnormal_glial_cell0.61957621
140MP0002971_abnormal_brown_adipose0.61271532
141MP0005334_abnormal_fat_pad0.57964732
142MP0008873_increased_physiological_sensi0.57547964
143MP0010368_abnormal_lymphatic_system0.57489102
144MP0002796_impaired_skin_barrier0.56231772
145MP0005220_abnormal_exocrine_pancreas0.49925585
146MP0005535_abnormal_body_temperature0.49440558
147MP0000462_abnormal_digestive_system0.49422978
148MP0003638_abnormal_response/metabolism_0.49305308
149MP0002136_abnormal_kidney_physiology0.48959627
150MP0005464_abnormal_platelet_physiology0.48885593
151MP0001756_abnormal_urination0.47422868
152MP0000639_abnormal_adrenal_gland0.46347073
153MP0001661_extended_life_span0.45395132
154MP0006035_abnormal_mitochondrial_morpho0.45043395
155MP0005395_other_phenotype0.44880477
156MP0004043_abnormal_pH_regulation0.43512685
157MP0008874_decreased_physiological_sensi0.42076519
158MP0005166_decreased_susceptibility_to0.40637744
159MP0004782_abnormal_surfactant_physiolog0.39856523
160MP0005670_abnormal_white_adipose0.39839663
161MP0009384_cardiac_valve_regurgitation0.39584069
162MP0001663_abnormal_digestive_system0.38831810
163MP0005248_abnormal_Harderian_gland0.38318516
164MP0001881_abnormal_mammary_gland0.37106033
165MP0003953_abnormal_hormone_level0.37090393
166MP0005381_digestive/alimentary_phenotyp0.36990915
167MP0003436_decreased_susceptibility_to0.36970979
168MP0003075_altered_response_to0.36397104
169MP0003724_increased_susceptibility_to0.35237297
170MP0004130_abnormal_muscle_cell0.34223177
171MP0000579_abnormal_nail_morphology0.34112347
172MP0005167_abnormal_blood-brain_barrier0.32286189
173MP0003300_gastrointestinal_ulcer0.30915637
174MP0004147_increased_porphyrin_level0.30865416
175MP0009379_abnormal_foot_pigmentation0.30380840
176MP0000249_abnormal_blood_vessel0.30362386
177MP0009115_abnormal_fat_cell0.30322783
178MP0004883_abnormal_blood_vessel0.30258537
179MP0003453_abnormal_keratinocyte_physiol0.28873682
180MP0000538_abnormal_urinary_bladder0.28391982
181MP0001845_abnormal_inflammatory_respons0.27922210
182MP0004947_skin_inflammation0.25140510
183MP0010155_abnormal_intestine_physiology0.25110040
184MP0000477_abnormal_intestine_morphology0.24752032

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.38040334
2Hypobetalipoproteinemia (HP:0003563)7.37587856
3Deep venous thrombosis (HP:0002625)6.91936668
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.80927745
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.75860308
6Xanthomatosis (HP:0000991)6.16911757
7Prolonged partial thromboplastin time (HP:0003645)5.93456547
8Hypolipoproteinemia (HP:0010981)5.06840481
9Fat malabsorption (HP:0002630)4.96846919
10Complement deficiency (HP:0004431)4.96662623
11Hyperlipoproteinemia (HP:0010980)4.93418083
12Conjugated hyperbilirubinemia (HP:0002908)4.89616716
13Epidermoid cyst (HP:0200040)4.66535021
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.55980888
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.54502742
16Joint hemorrhage (HP:0005261)4.38548611
17Hyperammonemia (HP:0001987)4.34596728
18Abnormality of the common coagulation pathway (HP:0010990)4.29227537
19Hyperglycinemia (HP:0002154)4.02345200
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.95365840
21Hyperglycinuria (HP:0003108)3.93112595
22Hypoglycemic coma (HP:0001325)3.90490029
23Hypercholesterolemia (HP:0003124)3.87511161
24Hyperbilirubinemia (HP:0002904)3.82492639
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.79396196
26Hypoalphalipoproteinemia (HP:0003233)3.78591006
27Ketosis (HP:0001946)3.73267315
28Abnormality of serine family amino acid metabolism (HP:0010894)3.71859610
29Abnormality of glycine metabolism (HP:0010895)3.71859610
30Acanthocytosis (HP:0001927)3.68998262
31Abnormality of methionine metabolism (HP:0010901)3.65591844
32Abnormality of complement system (HP:0005339)3.64673655
33Acute necrotizing encephalopathy (HP:0006965)3.54990649
34Steatorrhea (HP:0002570)3.52937143
35Concave nail (HP:0001598)3.50562277
36Abnormality of the intrinsic pathway (HP:0010989)3.40919217
37Abnormality of pyrimidine metabolism (HP:0004353)3.37889050
38Abnormal mitochondria in muscle tissue (HP:0008316)3.35986787
39Progressive macrocephaly (HP:0004481)3.28373545
40Mitochondrial inheritance (HP:0001427)3.16901003
41Malnutrition (HP:0004395)3.16612382
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.10394359
43Acute encephalopathy (HP:0006846)3.06035714
44Abnormality of nucleobase metabolism (HP:0010932)3.05364165
45Pancreatic cysts (HP:0001737)3.03785514
46Abnormality of fatty-acid metabolism (HP:0004359)3.01890852
47Skin nodule (HP:0200036)2.93777561
48Cholecystitis (HP:0001082)2.92960715
49Abnormal gallbladder physiology (HP:0012438)2.92960715
50Abnormality of purine metabolism (HP:0004352)2.89101723
51Ketoacidosis (HP:0001993)2.86598708
52Increased CSF lactate (HP:0002490)2.81658983
53True hermaphroditism (HP:0010459)2.76432708
54Hepatic necrosis (HP:0002605)2.73231650
55Pancreatic fibrosis (HP:0100732)2.72911694
56Hepatocellular carcinoma (HP:0001402)2.71728298
57Spontaneous abortion (HP:0005268)2.71218883
58Hypoglycemic seizures (HP:0002173)2.67461369
59Abnormal gallbladder morphology (HP:0012437)2.67172902
60Metabolic acidosis (HP:0001942)2.65948841
61Myocardial infarction (HP:0001658)2.65551762
62Hepatocellular necrosis (HP:0001404)2.60466916
63Cholelithiasis (HP:0001081)2.59725179
64Renal Fanconi syndrome (HP:0001994)2.59121705
65Lipid accumulation in hepatocytes (HP:0006561)2.58579560
66Systemic lupus erythematosus (HP:0002725)2.58471195
67Abnormality of serum amino acid levels (HP:0003112)2.54885387
68Type II lissencephaly (HP:0007260)2.53797195
693-Methylglutaconic aciduria (HP:0003535)2.52072837
70Abnormality of midbrain morphology (HP:0002418)2.51218922
71Molar tooth sign on MRI (HP:0002419)2.51218922
72Hypochromic microcytic anemia (HP:0004840)2.50802760
73Delayed CNS myelination (HP:0002188)2.49386559
74Increased hepatocellular lipid droplets (HP:0006565)2.47226565
75Methylmalonic acidemia (HP:0002912)2.45860655
76Lethargy (HP:0001254)2.44895800
77Poikilocytosis (HP:0004447)2.41770423
78Medial flaring of the eyebrow (HP:0010747)2.41526516
79Late onset (HP:0003584)2.40269221
80Abnormality of the renal cortex (HP:0011035)2.37462389
81Glomerulonephritis (HP:0000099)2.37105129
82Vascular calcification (HP:0004934)2.36974305
83Nephronophthisis (HP:0000090)2.34824264
84Myokymia (HP:0002411)2.32046476
85Focal motor seizures (HP:0011153)2.31260294
86Irritability (HP:0000737)2.30633519
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29254121
88Dicarboxylic aciduria (HP:0003215)2.29254121
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29036141
90Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29036141
91Amyloidosis (HP:0011034)2.28652339
92Hemiparesis (HP:0001269)2.28392720
93Esophageal varix (HP:0002040)2.26817773
94Gait imbalance (HP:0002141)2.26547219
95Hyperinsulinemic hypoglycemia (HP:0000825)2.24314215
96Hyperventilation (HP:0002883)2.23993729
97Increased circulating renin level (HP:0000848)2.23276419
98Abnormality of transition element cation homeostasis (HP:0011030)2.22328150
99Abnormality of iron homeostasis (HP:0011031)2.22093863
100Abnormality of proline metabolism (HP:0010907)2.21062024
101Hydroxyprolinuria (HP:0003080)2.21062024
102Gout (HP:0001997)2.20955674
103Spastic diplegia (HP:0001264)2.19435324
104Abnormal drinking behavior (HP:0030082)2.18663662
105Polydipsia (HP:0001959)2.18663662
106Large for gestational age (HP:0001520)2.18363363
107Mitral stenosis (HP:0001718)2.16877603
108Rickets (HP:0002748)2.15804852
109Neonatal onset (HP:0003623)2.15778247
110Renal cortical cysts (HP:0000803)2.14674579
111Nephrogenic diabetes insipidus (HP:0009806)2.14434674
112Cerebral edema (HP:0002181)2.13668148
113Abnormality of the gallbladder (HP:0005264)2.13558328
114Short tibia (HP:0005736)2.11826340
115Cardiovascular calcification (HP:0011915)2.10209640
116Abnormality of the renal medulla (HP:0100957)2.09789233
117Ileus (HP:0002595)2.09773224
118Hypothermia (HP:0002045)2.09562394
119Abnormal cartilage morphology (HP:0002763)2.09559965
120Sensorimotor neuropathy (HP:0007141)2.08438137
121Recurrent gram-negative bacterial infections (HP:0005420)2.08316891
122Menorrhagia (HP:0000132)2.08308645
123Aplasia/Hypoplasia of the tibia (HP:0005772)2.08203159
124Abnormality of urine glucose concentration (HP:0011016)2.07788927
125Glycosuria (HP:0003076)2.07788927
126Male pseudohermaphroditism (HP:0000037)2.07741465
127Gingival bleeding (HP:0000225)2.07664873
128Abnormality of the proximal phalanges of the hand (HP:0009834)2.06208251
129Abnormality of vitamin metabolism (HP:0100508)2.05775191
130Cystic liver disease (HP:0006706)2.05697839
131Progressive cerebellar ataxia (HP:0002073)2.05636376
132Congenital primary aphakia (HP:0007707)2.04705126
133Aplasia/hypoplasia of the uterus (HP:0008684)2.04130128
134Reticulocytosis (HP:0001923)2.02363836
135Focal seizures (HP:0007359)2.01359262
136Pancreatitis (HP:0001733)2.00627090
137Abnormal enzyme/coenzyme activity (HP:0012379)1.96974844
138Symptomatic seizures (HP:0011145)1.95183122
139Keratoconus (HP:0000563)1.94588683
140Increased corneal curvature (HP:0100692)1.94588683
141Vomiting (HP:0002013)1.92014782
142Nephritis (HP:0000123)1.91922132
143Hypomagnesemia (HP:0002917)1.91048746
144Cerebellar dysplasia (HP:0007033)1.90960443
145Increased intramyocellular lipid droplets (HP:0012240)1.89373813
146Opisthotonus (HP:0002179)1.88449841
147Hyperphosphaturia (HP:0003109)1.87969282
148Polyuria (HP:0000103)1.87322339
149Brushfield spots (HP:0001088)1.86117453
150Hyperglycemia (HP:0003074)1.86095074
151Abnormality of renal resorption (HP:0011038)1.86014670
152Right ventricular cardiomyopathy (HP:0011663)1.85737173
153Increased purine levels (HP:0004368)1.85193599
154Hyperuricemia (HP:0002149)1.85193599
155Hemorrhage of the eye (HP:0011885)1.84734924
156Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84586923
157Abnormality of alanine metabolism (HP:0010916)1.84586923
158Hyperalaninemia (HP:0003348)1.84586923
159Congenital, generalized hypertrichosis (HP:0004540)1.84208886
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.83132204
161Respiratory failure (HP:0002878)1.82819343
162Methylmalonic aciduria (HP:0012120)1.82798341
163Limb dystonia (HP:0002451)1.82083244
164Genital tract atresia (HP:0001827)1.80902538
165Sclerocornea (HP:0000647)1.80323332
166Poor suck (HP:0002033)1.79095784
167Congenital stationary night blindness (HP:0007642)1.78993240
168Generalized aminoaciduria (HP:0002909)1.78729208
169Vaginal atresia (HP:0000148)1.76804212
170Metabolic alkalosis (HP:0200114)1.75623106
171Retinal dysplasia (HP:0007973)1.75300875
172Tubular atrophy (HP:0000092)1.73935573
173Agitation (HP:0000713)1.72690571
174Lactic acidosis (HP:0003128)1.72573578
175Furrowed tongue (HP:0000221)1.71820805
176Febrile seizures (HP:0002373)1.71780002
177Gaze-evoked nystagmus (HP:0000640)1.70365303
178Epileptiform EEG discharges (HP:0011182)1.69631262
179Oligomenorrhea (HP:0000876)1.68647235
180Optic disc pallor (HP:0000543)1.67858357
181Increased serum lactate (HP:0002151)1.67556368
182Increased muscle lipid content (HP:0009058)1.67039497
183Atonic seizures (HP:0010819)1.66428364
184Severe muscular hypotonia (HP:0006829)1.65618776
185Proximal tubulopathy (HP:0000114)1.65414141
186Occipital encephalocele (HP:0002085)1.64121700
187Goiter (HP:0000853)1.64106433
188Amblyopia (HP:0000646)1.63844496
189EEG with generalized epileptiform discharges (HP:0011198)1.63260500
190Akinesia (HP:0002304)1.62212662
191Pendular nystagmus (HP:0012043)1.62090317
192Syncope (HP:0001279)1.60098449
193Lissencephaly (HP:0001339)1.59498940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.52428379
2ERN14.71478523
3TAOK33.91520416
4MST1R3.78948033
5FGFR43.75845243
6SIK13.51761567
7FRK3.27225402
8WNK33.12257800
9PINK12.98878773
10ERBB42.81603872
11MAP3K122.74832403
12CASK2.73683565
13MARK12.36147282
14LIMK12.35791849
15INSRR2.32458331
16GRK62.29332598
17MAP4K21.98869373
18TESK11.97715468
19PTK61.93392206
20DAPK21.92374051
21PHKG11.87132997
22PHKG21.87132997
23MAP2K41.85347865
24MAPK131.79765033
25PNCK1.75005885
26MAPK111.72534178
27RIPK11.66271556
28PKN21.62147354
29ADRBK21.61642065
30BMPR1B1.60758883
31MAPKAPK31.58942176
32WEE11.58568940
33MUSK1.58222837
34MAP3K101.56797038
35VRK21.56001367
36BRSK21.55177730
37MET1.54125086
38LATS11.53859774
39OXSR11.52403227
40TYK21.47408938
41STK391.46006144
42MAP3K71.35714804
43NUAK11.33222399
44LMTK21.32930677
45TRIB31.32599091
46CSNK1G31.32426104
47DYRK21.31006202
48CSNK1G21.30599739
49ERBB21.30473705
50PLK21.29963465
51PIK3CG1.28888586
52EPHB11.26977201
53ABL21.25576986
54TLK11.25378895
55MAPKAPK51.23190898
56MAP3K111.20710253
57MAP2K71.19767854
58ZAK1.19312364
59GRK51.19073741
60CSNK1A1L1.17857084
61MAP3K21.17277839
62FLT31.15772720
63PRKG21.15517478
64NTRK31.11225545
65PRKCE1.10655081
66PRKAA21.10594924
67NEK91.08460358
68MAP2K21.07814143
69EIF2AK11.04189252
70JAK21.03199223
71CAMK2B1.00296405
72MAP2K60.99962655
73MINK10.98425464
74BRSK10.97830957
75PIK3CA0.97467490
76TBK10.95733346
77WNK40.95497610
78KSR20.94693211
79MAP3K140.93066419
80PTK20.90278933
81TRIM280.90249630
82KDR0.90186462
83OBSCN0.89014770
84JAK10.87772855
85STK160.86013428
86MAPK40.85889486
87PRKACG0.85465697
88MAP2K10.85458744
89CAMK2A0.84676521
90NTRK20.84515879
91TNIK0.84471495
92VRK10.82988249
93PBK0.81332562
94CAMK2G0.80601739
95CAMK2D0.79613524
96EPHB20.79526577
97STK38L0.78309691
98PRKCZ0.78219392
99EPHA20.77709439
100DYRK1B0.77661658
101MAP3K30.76836058
102MAPK150.76771284
103ICK0.75914921
104MAP3K40.75530432
105ILK0.73400574
106FGFR20.72879498
107IRAK30.71210885
108PRKCI0.70924983
109CSK0.70407783
110PAK60.69850317
111ADRBK10.68653904
112ERBB30.68351092
113GSK3A0.66095636
114MAP3K130.65620992
115CDK60.65441814
116MAP3K10.64997921
117PDK20.63784077
118CAMK1D0.63495271
119BMX0.62047780
120PDPK10.59336811
121PRKAA10.57136764
122CCNB10.56666075
123DAPK10.56631435
124CAMK10.54623835
125PAK30.53953504
126MAPK120.53760678
127CSNK1A10.52612808
128EPHA30.52582926
129PRKCQ0.51040442
130PRKACA0.51028937
131ROCK10.50967780
132CSF1R0.50403340
133RPS6KA50.50336408
134MYLK0.49323328
135UHMK10.47541887
136DAPK30.47170840
137TIE10.46599325
138MAP2K30.46527830
139CDK80.45141362
140PIM20.44808171
141CDK50.44637426
142RPS6KB20.44016480
143TGFBR20.43117455
144AKT30.41960843
145STK380.41748255
146NEK60.41582259
147PRKD30.40450130
148CSNK1D0.40336961
149MAP3K80.39771965
150PRKCA0.38949291
151SGK4940.38796188
152SGK2230.38796188
153EGFR0.37477047
154IGF1R0.37413968
155PLK30.36374605
156EPHA40.36194090
157BCR0.35618031
158PRKG10.35419545
159PDK10.33611070
160IKBKE0.33416006
161MTOR0.33320646
162GRK10.30120823
163RET0.29118046
164CAMK40.28420017
165NME10.28194223
166PDK30.25312908
167PDK40.25312908
168CSNK1G10.24804964
169NEK10.24702180
170PRKCG0.24227787
171CDK40.23994943
172SRC0.20769461
173MAPK70.20668733
174FER0.20070734
175SGK30.20038038
176TAOK10.19358992
177RPS6KA30.19172177

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.11776075
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.59161908
3Oxidative phosphorylation_Homo sapiens_hsa001903.47123353
4Nitrogen metabolism_Homo sapiens_hsa009103.39902293
5* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.92132623
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.85454325
7Arginine biosynthesis_Homo sapiens_hsa002202.82086432
8Tryptophan metabolism_Homo sapiens_hsa003802.77317725
9Parkinsons disease_Homo sapiens_hsa050122.70637888
10* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.61620412
11* Chemical carcinogenesis_Homo sapiens_hsa052042.57727846
12Caffeine metabolism_Homo sapiens_hsa002322.57476298
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43676869
14Complement and coagulation cascades_Homo sapiens_hsa046102.40135005
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36610939
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33040736
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27940028
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22348309
19Cardiac muscle contraction_Homo sapiens_hsa042602.17882094
20Protein export_Homo sapiens_hsa030602.16824475
21Fatty acid degradation_Homo sapiens_hsa000712.13036827
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09260243
23Nicotine addiction_Homo sapiens_hsa050332.07481902
24Alzheimers disease_Homo sapiens_hsa050102.06710748
25Histidine metabolism_Homo sapiens_hsa003401.92804148
26Butanoate metabolism_Homo sapiens_hsa006501.88004687
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.84295052
28Fat digestion and absorption_Homo sapiens_hsa049751.84248432
29Peroxisome_Homo sapiens_hsa041461.77126120
30Huntingtons disease_Homo sapiens_hsa050161.77077534
31Bile secretion_Homo sapiens_hsa049761.73217510
32Retinol metabolism_Homo sapiens_hsa008301.73131658
33Starch and sucrose metabolism_Homo sapiens_hsa005001.72954936
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.72891110
35PPAR signaling pathway_Homo sapiens_hsa033201.68523379
36Selenocompound metabolism_Homo sapiens_hsa004501.64636135
37Sulfur metabolism_Homo sapiens_hsa009201.64427860
38Folate biosynthesis_Homo sapiens_hsa007901.55628567
39Propanoate metabolism_Homo sapiens_hsa006401.53613419
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52135326
41Collecting duct acid secretion_Homo sapiens_hsa049661.51677738
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50294804
43Staphylococcus aureus infection_Homo sapiens_hsa051501.50198323
44Fatty acid metabolism_Homo sapiens_hsa012121.47906963
45Phototransduction_Homo sapiens_hsa047441.46484692
46beta-Alanine metabolism_Homo sapiens_hsa004101.45234982
47Synaptic vesicle cycle_Homo sapiens_hsa047211.43651789
48GABAergic synapse_Homo sapiens_hsa047271.43175013
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42373396
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41528041
51* Glutathione metabolism_Homo sapiens_hsa004801.41370859
52Pyruvate metabolism_Homo sapiens_hsa006201.36850794
53ABC transporters_Homo sapiens_hsa020101.35152893
54Steroid biosynthesis_Homo sapiens_hsa001001.35046835
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.34301067
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32987480
57Phenylalanine metabolism_Homo sapiens_hsa003601.31965409
58Insulin secretion_Homo sapiens_hsa049111.30447529
59Morphine addiction_Homo sapiens_hsa050321.25155701
60Circadian entrainment_Homo sapiens_hsa047131.21280499
61Biosynthesis of amino acids_Homo sapiens_hsa012301.19869720
62Vitamin digestion and absorption_Homo sapiens_hsa049771.18775827
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17522364
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.17300703
65Carbon metabolism_Homo sapiens_hsa012001.15301754
66Tyrosine metabolism_Homo sapiens_hsa003501.15017186
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10414092
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09130801
69Cyanoamino acid metabolism_Homo sapiens_hsa004601.07945763
70Glutamatergic synapse_Homo sapiens_hsa047241.05943957
71Fatty acid elongation_Homo sapiens_hsa000621.05778698
72Proteasome_Homo sapiens_hsa030501.05404458
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02621650
74RNA polymerase_Homo sapiens_hsa030201.02279249
75Vitamin B6 metabolism_Homo sapiens_hsa007501.01956189
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00001834
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99897936
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97604592
79Ribosome_Homo sapiens_hsa030100.97041230
80Arginine and proline metabolism_Homo sapiens_hsa003300.90948190
81Regulation of autophagy_Homo sapiens_hsa041400.90724981
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90176959
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89290471
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88878551
85Dopaminergic synapse_Homo sapiens_hsa047280.87272985
86Taste transduction_Homo sapiens_hsa047420.87238027
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86479596
88Sulfur relay system_Homo sapiens_hsa041220.82490870
89Amphetamine addiction_Homo sapiens_hsa050310.81998316
90Salivary secretion_Homo sapiens_hsa049700.80966764
91Vibrio cholerae infection_Homo sapiens_hsa051100.80606211
92Circadian rhythm_Homo sapiens_hsa047100.79780619
93Cocaine addiction_Homo sapiens_hsa050300.79670199
94Gastric acid secretion_Homo sapiens_hsa049710.74867875
95Pentose phosphate pathway_Homo sapiens_hsa000300.73067327
96Glycerolipid metabolism_Homo sapiens_hsa005610.68510132
97Serotonergic synapse_Homo sapiens_hsa047260.68199297
98Olfactory transduction_Homo sapiens_hsa047400.66140782
99Galactose metabolism_Homo sapiens_hsa000520.64921321
100Lysine degradation_Homo sapiens_hsa003100.64428807
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62820108
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61366091
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61017946
104Fructose and mannose metabolism_Homo sapiens_hsa000510.60346755
105Basal transcription factors_Homo sapiens_hsa030220.58736096
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58381966
107Renin secretion_Homo sapiens_hsa049240.57746005
108Hedgehog signaling pathway_Homo sapiens_hsa043400.56292434
109Calcium signaling pathway_Homo sapiens_hsa040200.55685280
110Pancreatic secretion_Homo sapiens_hsa049720.54732748
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51137889
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51000908
113One carbon pool by folate_Homo sapiens_hsa006700.50500457
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50188418
115Purine metabolism_Homo sapiens_hsa002300.50116223
116N-Glycan biosynthesis_Homo sapiens_hsa005100.50077392
117Fatty acid biosynthesis_Homo sapiens_hsa000610.47253356
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46727378
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45210299
120Dilated cardiomyopathy_Homo sapiens_hsa054140.43449403
121Metabolic pathways_Homo sapiens_hsa011000.42601620
122Linoleic acid metabolism_Homo sapiens_hsa005910.30183903
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27734844
124Prion diseases_Homo sapiens_hsa050200.27459379
125Mineral absorption_Homo sapiens_hsa049780.26344427
126Renin-angiotensin system_Homo sapiens_hsa046140.18665109
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.16273263
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14882972
129Insulin resistance_Homo sapiens_hsa049310.13718947
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13591415
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09379504
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.07890772
133Glucagon signaling pathway_Homo sapiens_hsa049220.01573154
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2800040
135Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2768743
136Amoebiasis_Homo sapiens_hsa05146-0.2608818
137Pertussis_Homo sapiens_hsa05133-0.2539042
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2052824
139Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1686733
140Hepatitis C_Homo sapiens_hsa05160-0.1629244
141Bladder cancer_Homo sapiens_hsa05219-0.1571395
142Ether lipid metabolism_Homo sapiens_hsa00565-0.1562523
143Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1547709
144Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1485226
145African trypanosomiasis_Homo sapiens_hsa05143-0.1385241
146Type II diabetes mellitus_Homo sapiens_hsa04930-0.1092967
147Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1084675
148Insulin signaling pathway_Homo sapiens_hsa04910-0.1046041
149AMPK signaling pathway_Homo sapiens_hsa04152-0.0737943
150Protein digestion and absorption_Homo sapiens_hsa04974-0.0670195
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0221207

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