GSTM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* xenobiotic catabolic process (GO:0042178)8.10510057
2* response to nitrosative stress (GO:0051409)7.63614600
3gonadal mesoderm development (GO:0007506)6.38998580
4glucuronate metabolic process (GO:0019585)5.70367710
5uronic acid metabolic process (GO:0006063)5.70367710
6cellular glucuronidation (GO:0052695)5.50100216
7sulfur amino acid catabolic process (GO:0000098)5.22629970
8* benzene-containing compound metabolic process (GO:0042537)4.57882405
9positive regulation of male gonad development (GO:2000020)4.51139036
10androgen biosynthetic process (GO:0006702)4.35240667
11regulation of male gonad development (GO:2000018)4.31380803
12aggressive behavior (GO:0002118)4.20188477
13cilium or flagellum-dependent cell motility (GO:0001539)4.20021126
14* glutathione derivative metabolic process (GO:1901685)4.13699684
15* glutathione derivative biosynthetic process (GO:1901687)4.13699684
16L-ascorbic acid metabolic process (GO:0019852)3.93481024
17valine metabolic process (GO:0006573)3.89627426
18sex determination (GO:0007530)3.77793520
19hormone catabolic process (GO:0042447)3.74789634
20alpha-linolenic acid metabolic process (GO:0036109)3.66591499
21myofibril assembly (GO:0030239)3.63793368
22regulation of female receptivity (GO:0045924)3.57464583
23regulation of cholesterol biosynthetic process (GO:0045540)3.56492110
24cysteine metabolic process (GO:0006534)3.53415256
25negative regulation of protein localization to cell surface (GO:2000009)3.45379634
26glyoxylate metabolic process (GO:0046487)3.42995937
27L-phenylalanine catabolic process (GO:0006559)3.42691387
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.42691387
29ethanol oxidation (GO:0006069)3.42618314
30negative regulation of cytosolic calcium ion concentration (GO:0051481)3.41304182
31* glutathione metabolic process (GO:0006749)3.40439793
32actin-myosin filament sliding (GO:0033275)3.36039529
33muscle filament sliding (GO:0030049)3.36039529
34cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.34272713
35reverse cholesterol transport (GO:0043691)3.30357542
36high-density lipoprotein particle remodeling (GO:0034375)3.29662869
37regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.26014261
38phenylpropanoid metabolic process (GO:0009698)3.24667175
39L-phenylalanine metabolic process (GO:0006558)3.24508516
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.24508516
41* regulation of skeletal muscle contraction (GO:0014819)3.21691425
42regulation of relaxation of muscle (GO:1901077)3.19267351
43* regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.18995631
44bile acid biosynthetic process (GO:0006699)3.12175419
45positive regulation of vascular permeability (GO:0043117)3.11466085
46axoneme assembly (GO:0035082)3.08955495
47regulation of phospholipase A2 activity (GO:0032429)3.05720215
48homocysteine metabolic process (GO:0050667)3.05486663
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01186948
50bundle of His cell to Purkinje myocyte communication (GO:0086069)2.99485150
51one-carbon compound transport (GO:0019755)2.98970761
52cardiac myofibril assembly (GO:0055003)2.98079570
53skeletal muscle adaptation (GO:0043501)2.97160085
54positive regulation of digestive system process (GO:0060456)2.96782847
55aromatic amino acid family catabolic process (GO:0009074)2.96058900
56metanephric mesenchyme development (GO:0072075)2.94720444
57fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.94347381
58cilium movement (GO:0003341)2.94223305
59atrioventricular valve morphogenesis (GO:0003181)2.93928296
60neuronal action potential propagation (GO:0019227)2.92574586
61regulation of female gonad development (GO:2000194)2.92046890
62complement activation, alternative pathway (GO:0006957)2.91129445
63renal absorption (GO:0070293)2.90773743
64female mating behavior (GO:0060180)2.89421781
65positive regulation of fatty acid beta-oxidation (GO:0032000)2.88791915
66peptidyl-glutamic acid carboxylation (GO:0017187)2.88346603
67protein carboxylation (GO:0018214)2.88346603
68fatty acid beta-oxidation (GO:0006635)2.88243140
69sex differentiation (GO:0007548)2.87713826
70definitive hemopoiesis (GO:0060216)2.86399517
71epoxygenase P450 pathway (GO:0019373)2.86020869
72negative regulation of lipase activity (GO:0060192)2.85605127
73positive regulation of p38MAPK cascade (GO:1900745)2.85258543
74negative regulation of fatty acid transport (GO:2000192)2.85190070
75glomerulus development (GO:0032835)2.84516812
76branched-chain amino acid catabolic process (GO:0009083)2.84321818
77regulation of cardioblast proliferation (GO:0003264)2.83994774
78regulation of secondary heart field cardioblast proliferation (GO:0003266)2.83994774
79actin-mediated cell contraction (GO:0070252)2.83809998
80regulation of fibrinolysis (GO:0051917)2.83359832
81regulation of cholesterol metabolic process (GO:0090181)2.82844004
82amino-acid betaine metabolic process (GO:0006577)2.82398037
83androgen metabolic process (GO:0008209)2.81157392
84response to follicle-stimulating hormone (GO:0032354)2.81113046
85positive regulation of vasculogenesis (GO:2001214)2.79153642
86glomerular basement membrane development (GO:0032836)2.75379764
87phospholipid homeostasis (GO:0055091)2.74645519
88* xenobiotic metabolic process (GO:0006805)2.74604324
89intestinal cholesterol absorption (GO:0030299)2.74498165
90fatty acid oxidation (GO:0019395)2.73932863
91triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.73268063
92interkinetic nuclear migration (GO:0022027)2.72773197
93negative regulation of fibrinolysis (GO:0051918)2.72500747
94urinary tract smooth muscle contraction (GO:0014848)2.71867153
95tachykinin receptor signaling pathway (GO:0007217)2.71293387
96branched-chain amino acid metabolic process (GO:0009081)2.70099823
97drug metabolic process (GO:0017144)2.70088005
98regulation of protein activation cascade (GO:2000257)2.69463644
99monocarboxylic acid catabolic process (GO:0072329)2.67822840
100tonic smooth muscle contraction (GO:0014820)2.67633767
101drug transmembrane transport (GO:0006855)2.67617484
102aldehyde catabolic process (GO:0046185)2.66778967
103lipid oxidation (GO:0034440)2.66153063
104flavonoid metabolic process (GO:0009812)2.65373147
105biotin metabolic process (GO:0006768)2.64945788
106kynurenine metabolic process (GO:0070189)2.64856416
107interleukin-6-mediated signaling pathway (GO:0070102)2.63270619
108positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.62880205
109sarcoplasmic reticulum calcium ion transport (GO:0070296)2.62823507
110tryptophan catabolic process (GO:0006569)2.62687382
111indole-containing compound catabolic process (GO:0042436)2.62687382
112indolalkylamine catabolic process (GO:0046218)2.62687382
113creatine metabolic process (GO:0006600)2.59547920
114kidney mesenchyme development (GO:0072074)2.59523308
115regulation of complement activation (GO:0030449)2.59485402
116photoreceptor cell maintenance (GO:0045494)2.58828441
117regulation of cholesterol esterification (GO:0010872)2.58757510
118regulation of bile acid biosynthetic process (GO:0070857)2.57950460
119tryptophan metabolic process (GO:0006568)2.57918106
1203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.57188465
121purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.57188465
122serine family amino acid catabolic process (GO:0009071)2.56377035
123sulfate transmembrane transport (GO:1902358)2.55318182
124estrogen metabolic process (GO:0008210)2.54228837
125* regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.54129060
126regulation of cholesterol homeostasis (GO:2000188)2.52940583
127bile acid metabolic process (GO:0008206)2.52107455
128indolalkylamine metabolic process (GO:0006586)2.52067787
129endocardial cushion morphogenesis (GO:0003203)2.51900307
130carnitine metabolic process (GO:0009437)2.51008904
131fatty acid catabolic process (GO:0009062)2.50867807
132response to epinephrine (GO:0071871)2.49998653
133regulation of fatty acid beta-oxidation (GO:0031998)2.49651518
134epithelial cilium movement (GO:0003351)2.48823924
135positive regulation of fatty acid oxidation (GO:0046321)2.46455707
136membrane depolarization during action potential (GO:0086010)2.46000053
137carnitine transmembrane transport (GO:1902603)2.43263957
138* positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.43118385
139cardiolipin metabolic process (GO:0032048)2.41115214
140growth hormone receptor signaling pathway (GO:0060396)2.41019132
141* regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.40656232
142striated muscle atrophy (GO:0014891)2.39209578
143membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.37895602
144quaternary ammonium group transport (GO:0015697)2.34011152
145drinking behavior (GO:0042756)2.33863872
146detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.33048219
147auditory receptor cell stereocilium organization (GO:0060088)2.32990106
148negative regulation of complement activation (GO:0045916)2.31587243
149fatty acid transmembrane transport (GO:1902001)2.31565976
150carnitine transport (GO:0015879)2.30939275
151amino-acid betaine transport (GO:0015838)2.30939275
152phosphatidylglycerol biosynthetic process (GO:0006655)2.30234269
153NAD biosynthetic process (GO:0009435)2.27499067
154neurotransmitter catabolic process (GO:0042135)2.25076620
155regulation of vasculogenesis (GO:2001212)2.23977685
156regulation of cell communication by electrical coupling (GO:0010649)2.23616012
157cellular ketone body metabolic process (GO:0046950)2.22983592
158dermatan sulfate metabolic process (GO:0030205)2.22274434
159peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.21563321
160* regulation of striated muscle contraction (GO:0006942)2.20349852
161regulation of protein glycosylation (GO:0060049)2.19953165
162cellular response to sterol (GO:0036315)2.18983377
163skeletal muscle contraction (GO:0003009)2.18331663
164cellular response to epinephrine stimulus (GO:0071872)2.18040115
165striated muscle contraction (GO:0006941)2.17844268
166* positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.16360060
167cellular response to growth hormone stimulus (GO:0071378)2.15742391
168myotube cell development (GO:0014904)2.14573667
169negative regulation of humoral immune response (GO:0002921)2.14032324
170regulation of actin filament-based movement (GO:1903115)2.11486520
171cGMP metabolic process (GO:0046068)2.10957729
172negative regulation of B cell mediated immunity (GO:0002713)2.10686365
173negative regulation of immunoglobulin mediated immune response (GO:0002890)2.10686365
174behavioral response to ethanol (GO:0048149)2.10303647
175regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.09095298
176positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.09005490
177regulation of sarcomere organization (GO:0060297)2.08557936
178* regulation of calcium ion transmembrane transporter activity (GO:1901019)2.08080347
179* regulation of calcium ion transmembrane transport (GO:1903169)2.08080347
180actin filament-based movement (GO:0030048)2.07946907
181motile cilium assembly (GO:0044458)2.07375994
182muscle contraction (GO:0006936)2.06346232
183response to misfolded protein (GO:0051788)2.06304507
184positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.05856994
185skeletal muscle tissue regeneration (GO:0043403)2.02706275
186striated muscle adaptation (GO:0014888)2.02345982
187positive regulation of uterine smooth muscle contraction (GO:0070474)2.01244487
188negative regulation of protein activation cascade (GO:2000258)2.01001065
189postsynaptic membrane organization (GO:0001941)2.00981403
190hyperosmotic salinity response (GO:0042538)1.99915991
191tyrosine phosphorylation of STAT protein (GO:0007260)1.99051139
192regulation of sequestering of triglyceride (GO:0010889)1.97975889
193cGMP-mediated signaling (GO:0019934)1.96849291
194muscle fiber development (GO:0048747)1.96767320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.28396322
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.52817138
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.52770869
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.06911918
5EZH2_22144423_ChIP-Seq_EOC_Human4.04332461
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.02424940
7CLOCK_20551151_ChIP-Seq_293T_Human3.89304557
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.82167491
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.72841872
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.21856886
11* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.07318816
12RARG_19884340_ChIP-ChIP_MEFs_Mouse3.03946567
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.01131721
14TRIM28_21343339_ChIP-Seq_HEK293_Human3.00481680
15GBX2_23144817_ChIP-Seq_PC3_Human2.96271496
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.63497635
17* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.63128186
18DROSHA_22980978_ChIP-Seq_HELA_Human2.36239300
19IGF1R_20145208_ChIP-Seq_DFB_Human2.33934354
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.22877446
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.22877446
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.22877446
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.14992452
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10683432
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.09578354
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.03205275
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.98790829
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93158177
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84757101
30ZNF263_19887448_ChIP-Seq_K562_Human1.83500616
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.77752341
32VDR_22108803_ChIP-Seq_LS180_Human1.76978473
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.75960131
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75533600
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68706973
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66902443
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.66022820
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64621843
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63754725
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.62613814
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62585921
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59896036
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55728575
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53954544
45ZNF274_21170338_ChIP-Seq_K562_Hela1.52941895
46AR_21572438_ChIP-Seq_LNCaP_Human1.52468810
47CDX2_20551321_ChIP-Seq_CACO-2_Human1.49334724
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.49100112
49SMAD4_21799915_ChIP-Seq_A2780_Human1.45602782
50* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44686672
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44607881
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43614438
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42732433
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42162952
55GATA1_22025678_ChIP-Seq_K562_Human1.41556357
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41547420
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41463460
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41322944
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41013675
60* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40708234
61* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40708234
62SOX2_20726797_ChIP-Seq_SW620_Human1.40321677
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39387608
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38479310
65STAT3_23295773_ChIP-Seq_U87_Human1.35804085
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32926775
67GATA4_25053715_ChIP-Seq_YYC3_Human1.32583679
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32211501
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31687234
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30613883
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30515505
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29892101
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26084777
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23099221
75CJUN_26792858_Chip-Seq_BT549_Human1.22796141
76TCF4_23295773_ChIP-Seq_U87_Human1.22755351
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22452911
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22218788
79SCL_19346495_ChIP-Seq_HPC-7_Human1.20621938
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20519937
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20406737
82ER_23166858_ChIP-Seq_MCF-7_Human1.19891937
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18666933
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.17995973
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.17995973
86GATA3_24758297_ChIP-Seq_MCF-7_Human1.17848844
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17531126
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15288769
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14974544
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14974544
91AR_25329375_ChIP-Seq_VCAP_Human1.14779856
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14753605
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14224868
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14162190
95P300_19829295_ChIP-Seq_ESCs_Human1.12594440
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.11626069
97RACK7_27058665_Chip-Seq_MCF-7_Human1.11470532
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11453842
99MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11230342
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11022423
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10265777
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09974880
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09281089
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08456196
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07644743
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07177823
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06828915
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06826603
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06754609
110SMAD_19615063_ChIP-ChIP_OVARY_Human1.06522326
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06464346
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06198336
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.06078200
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05746695
115TAF15_26573619_Chip-Seq_HEK293_Human1.05102367
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.04973391
117FLI1_27457419_Chip-Seq_LIVER_Mouse1.04876046
118FOXA2_19822575_ChIP-Seq_HepG2_Human1.04720665
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.04548639
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04075936
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03889112
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03889112
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03811347
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03147712
125GATA2_21666600_ChIP-Seq_HMVEC_Human1.02956678
126CBP_20019798_ChIP-Seq_JUKART_Human1.02823964
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02823964
128P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02536356
129RXR_22108803_ChIP-Seq_LS180_Human1.01696887
130RUNX_20019798_ChIP-Seq_JUKART_Human1.01334666
131RUNX2_22187159_ChIP-Seq_PCA_Human1.00388994
132JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99512609
133TP53_16413492_ChIP-PET_HCT116_Human0.99252079
134REST_21632747_ChIP-Seq_MESCs_Mouse0.99027426
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98972533
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98404133
137EGR1_19374776_ChIP-ChIP_THP-1_Human0.98140055
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.97885780
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97484630
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97453998
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96602023
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.96309842
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95210397
144GATA6_25053715_ChIP-Seq_YYC3_Human0.95022488
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94550921
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94108652
147SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93531802
148SMAD3_21741376_ChIP-Seq_EPCs_Human0.93450642
149VDR_24787735_ChIP-Seq_THP-1_Human0.92879805
150AHR_22903824_ChIP-Seq_MCF-7_Human0.92734055
151CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92489158
152TCF4_22108803_ChIP-Seq_LS180_Human0.92194406
153TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92016937
154GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91902878
155HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91780565
156CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91317728
157ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90980906
158ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90962266
159ARNT_22903824_ChIP-Seq_MCF-7_Human0.90207981
160PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90038931
161SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89970196
162FOXO3_23340844_ChIP-Seq_DLD1_Human0.89942870
163FLI1_21867929_ChIP-Seq_TH2_Mouse0.89869973
164SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89552151
165SMAD3_21741376_ChIP-Seq_HESCs_Human0.89262081
166SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89204178
167ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89136257
168SMAD4_21741376_ChIP-Seq_EPCs_Human0.88961269
169KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88715494
170KDM2B_26808549_Chip-Seq_REH_Human0.87546873
171KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86773029
172TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85342745
173STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.85170478
174FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84143477
175Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83335964
176STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82429255
177UBF1/2_26484160_Chip-Seq_HMECs_Human0.82107874
178KLF5_25053715_ChIP-Seq_YYC3_Human0.82096281
179NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81361561
180SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77274605
181ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75033449
182WT1_19549856_ChIP-ChIP_CCG9911_Human0.74987260
183CREB1_26743006_Chip-Seq_LNCaP_Human0.74237712
184CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72093048
185NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.71905554
186BCAT_22108803_ChIP-Seq_LS180_Human0.71408370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.00962148
2MP0002139_abnormal_hepatobiliary_system4.17335641
3MP0005365_abnormal_bile_salt3.76838812
4MP0003646_muscle_fatigue3.53455402
5MP0004145_abnormal_muscle_electrophysio3.30768128
6MP0000751_myopathy3.18189141
7MP0005085_abnormal_gallbladder_physiolo3.17362259
8MP0008438_abnormal_cutaneous_collagen3.01508653
9MP0003705_abnormal_hypodermis_morpholog2.99171373
10MP0008995_early_reproductive_senescence2.88501953
11MP0004036_abnormal_muscle_relaxation2.84741571
12MP0005360_urolithiasis2.67141686
13MP0003195_calcinosis2.64136874
14MP0001501_abnormal_sleep_pattern2.44807509
15MP0000749_muscle_degeneration2.37897165
16MP0008789_abnormal_olfactory_epithelium2.37806197
17MP0010030_abnormal_orbit_morphology2.29768304
18MP0004130_abnormal_muscle_cell2.24221855
19MP0010329_abnormal_lipoprotein_level2.15879164
20MP0003186_abnormal_redox_activity2.14239737
21MP0010368_abnormal_lymphatic_system1.98016189
22MP0009384_cardiac_valve_regurgitation1.97852923
23MP0005646_abnormal_pituitary_gland1.95615290
24MP0005394_taste/olfaction_phenotype1.94546468
25MP0005499_abnormal_olfactory_system1.94546468
26MP0005275_abnormal_skin_tensile1.89571668
27MP0005377_hearing/vestibular/ear_phenot1.89361793
28MP0003878_abnormal_ear_physiology1.89361793
29MP0001968_abnormal_touch/_nociception1.88364862
30MP0002108_abnormal_muscle_morphology1.87431992
31MP0002254_reproductive_system_inflammat1.85639446
32MP0001666_abnormal_nutrient_absorption1.80903675
33MP0003252_abnormal_bile_duct1.80543374
34MP0005083_abnormal_biliary_tract1.77913709
35MP0003279_aneurysm1.75419041
36MP0005620_abnormal_muscle_contractility1.69889929
37MP0003806_abnormal_nucleotide_metabolis1.69469831
38MP0005647_abnormal_sex_gland1.69015180
39MP0004215_abnormal_myocardial_fiber1.68988739
40MP0001958_emphysema1.68593172
41MP0005408_hypopigmentation1.67718124
42MP0004272_abnormal_basement_membrane1.64769961
43MP0001984_abnormal_olfaction1.64206898
44MP0010386_abnormal_urinary_bladder1.61702185
45MP0002877_abnormal_melanocyte_morpholog1.61684552
46MP0005369_muscle_phenotype1.60234891
47MP0002735_abnormal_chemical_nociception1.60076103
48MP0002106_abnormal_muscle_physiology1.57761339
49MP0005645_abnormal_hypothalamus_physiol1.56772859
50MP0009053_abnormal_anal_canal1.56230320
51MP0004043_abnormal_pH_regulation1.55448754
52MP0002653_abnormal_ependyma_morphology1.54836368
53MP0000013_abnormal_adipose_tissue1.54797166
54MP0001486_abnormal_startle_reflex1.50281007
55MP0005332_abnormal_amino_acid1.50267131
56MP0002638_abnormal_pupillary_reflex1.47736093
57MP0003045_fibrosis1.47517522
58MP0002295_abnormal_pulmonary_circulatio1.46826429
59MP0005167_abnormal_blood-brain_barrier1.43148704
60MP0004484_altered_response_of1.42353720
61MP0002971_abnormal_brown_adipose1.41084338
62MP0009780_abnormal_chondrocyte_physiolo1.36441532
63MP0005551_abnormal_eye_electrophysiolog1.35237045
64MP0003137_abnormal_impulse_conducting1.34271513
65MP0009379_abnormal_foot_pigmentation1.33414377
66MP0006276_abnormal_autonomic_nervous1.32593916
67MP0005670_abnormal_white_adipose1.32310715
68MP0005503_abnormal_tendon_morphology1.31334064
69MP0000230_abnormal_systemic_arterial1.29854161
70MP0001970_abnormal_pain_threshold1.25335013
71MP0002736_abnormal_nociception_after1.23415170
72MP0004087_abnormal_muscle_fiber1.21348143
73MP0000759_abnormal_skeletal_muscle1.20357773
74MP0005319_abnormal_enzyme/_coenzyme1.19774970
75MP0004859_abnormal_synaptic_plasticity1.19755709
76MP0005535_abnormal_body_temperature1.19506416
77MP0002060_abnormal_skin_morphology1.19347305
78MP0008004_abnormal_stomach_pH1.18255400
79MP0006054_spinal_hemorrhage1.17410013
80MP0009745_abnormal_behavioral_response1.17290597
81MP0002138_abnormal_hepatobiliary_system1.15154481
82MP0003879_abnormal_hair_cell1.14951705
83MP0004085_abnormal_heartbeat1.13757897
84MP0000762_abnormal_tongue_morphology1.13470114
85MP0002132_abnormal_respiratory_system1.13228957
86MP0003786_premature_aging1.12804439
87MP0002733_abnormal_thermal_nociception1.12569011
88MP0002933_joint_inflammation1.11929939
89MP0004019_abnormal_vitamin_homeostasis1.09800084
90MP0000678_abnormal_parathyroid_gland1.09343595
91MP0002572_abnormal_emotion/affect_behav1.08715942
92MP0002127_abnormal_cardiovascular_syste1.07958822
93MP0005367_renal/urinary_system_phenotyp1.07747347
94MP0000516_abnormal_urinary_system1.07747347
95MP0003942_abnormal_urinary_system1.07670313
96MP0002118_abnormal_lipid_homeostasis1.07255911
97MP0009278_abnormal_bone_marrow1.07109073
98MP0002972_abnormal_cardiac_muscle1.06627884
99MP0002332_abnormal_exercise_endurance1.05584577
100MP0000537_abnormal_urethra_morphology1.05251894
101MP0001756_abnormal_urination1.05074935
102MP0002233_abnormal_nose_morphology1.04820105
103MP0009046_muscle_twitch1.04334514
104MP0003566_abnormal_cell_adhesion1.03900570
105MP0008569_lethality_at_weaning1.03196530
106MP0000534_abnormal_ureter_morphology1.03070283
107MP0005248_abnormal_Harderian_gland1.02930947
108MP0006138_congestive_heart_failure1.02834850
109MP0003191_abnormal_cellular_cholesterol1.02106848
110MP0002272_abnormal_nervous_system1.00796713
111MP0002269_muscular_atrophy1.00058030
112MP0001545_abnormal_hematopoietic_system0.99244245
113MP0005397_hematopoietic_system_phenotyp0.99244245
114MP0002734_abnormal_mechanical_nocicepti0.98852590
115MP0003635_abnormal_synaptic_transmissio0.97026866
116MP0001664_abnormal_digestion0.96331371
117MP0005023_abnormal_wound_healing0.95691836
118MP0003115_abnormal_respiratory_system0.95103634
119MP0008775_abnormal_heart_ventricle0.94964585
120MP0009840_abnormal_foam_cell0.94760531
121MP0009643_abnormal_urine_homeostasis0.94590827
122MP0000609_abnormal_liver_physiology0.93890281
123MP0005171_absent_coat_pigmentation0.93545142
124MP0003633_abnormal_nervous_system0.93477330
125MP0002168_other_aberrant_phenotype0.91991836
126MP0004142_abnormal_muscle_tone0.91313849
127MP0002064_seizures0.90793542
128MP0003183_abnormal_peptide_metabolism0.89819131
129MP0000747_muscle_weakness0.89547487
130MP0001986_abnormal_taste_sensitivity0.88219887
131MP0001346_abnormal_lacrimal_gland0.87251870
132MP0002067_abnormal_sensory_capabilities0.84913086
133MP0001661_extended_life_span0.83781671
134MP0003828_pulmonary_edema0.83529831
135MP0002249_abnormal_larynx_morphology0.83317388
136MP0002098_abnormal_vibrissa_morphology0.81916163
137MP0003936_abnormal_reproductive_system0.81276339
138MP0004883_abnormal_blood_vessel0.80745915
139MP0003136_yellow_coat_color0.80091649
140MP0005164_abnormal_response_to0.77836280
141MP0004147_increased_porphyrin_level0.76586357
142MP0001963_abnormal_hearing_physiology0.76547236
143MP0001879_abnormal_lymphatic_vessel0.76448968
144MP0005253_abnormal_eye_physiology0.76102839
145MP0000613_abnormal_salivary_gland0.75786563
146MP0005595_abnormal_vascular_smooth0.75613160
147MP0003941_abnormal_skin_development0.74872358
148MP0003724_increased_susceptibility_to0.73746858
149MP0003950_abnormal_plasma_membrane0.73451721
150MP0001919_abnormal_reproductive_system0.73076023
151MP0002102_abnormal_ear_morphology0.72848668
152MP0005508_abnormal_skeleton_morphology0.70709485
153MP0000767_abnormal_smooth_muscle0.70636006
154MP0002837_dystrophic_cardiac_calcinosis0.70475481
155MP0003690_abnormal_glial_cell0.70250799
156MP0010630_abnormal_cardiac_muscle0.69828537
157MP0004084_abnormal_cardiac_muscle0.68383957
158MP0005084_abnormal_gallbladder_morpholo0.67802319
159MP0002160_abnormal_reproductive_system0.67296471
160MP0005389_reproductive_system_phenotype0.66035834
161MP0003315_abnormal_perineum_morphology0.65794392
162MP0008872_abnormal_physiological_respon0.65244885
163MP0002009_preneoplasia0.63790063
164MP0005330_cardiomyopathy0.63349956
165MP0005220_abnormal_exocrine_pancreas0.62830898
166MP0000049_abnormal_middle_ear0.62730424
167MP0005666_abnormal_adipose_tissue0.62542449
168MP0004782_abnormal_surfactant_physiolog0.61746914
169MP0005388_respiratory_system_phenotype0.61448291
170MP0002133_abnormal_respiratory_system0.61448291
171MP0003300_gastrointestinal_ulcer0.61362946
172MP0001544_abnormal_cardiovascular_syste0.59599882
173MP0005385_cardiovascular_system_phenoty0.59599882
174MP0003453_abnormal_keratinocyte_physiol0.59256797
175MP0000598_abnormal_liver_morphology0.58826366

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.20903004
2Muscle fiber inclusion bodies (HP:0100299)4.35938272
3Gonadal dysgenesis (HP:0000133)4.13576915
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.11804280
5Nemaline bodies (HP:0003798)4.11660689
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.94014213
7Deep venous thrombosis (HP:0002625)3.67861667
8Right ventricular cardiomyopathy (HP:0011663)3.64659521
9Distal arthrogryposis (HP:0005684)3.64600662
10Male infertility (HP:0003251)3.49602045
11Male pseudohermaphroditism (HP:0000037)3.43311953
12Abnormal hemoglobin (HP:0011902)3.41418059
13Muscle fiber splitting (HP:0003555)3.40997162
14Protrusio acetabuli (HP:0003179)3.39844554
15Intrahepatic cholestasis (HP:0001406)3.36639551
16Muscle hypertrophy of the lower extremities (HP:0008968)3.31284808
17Genetic anticipation (HP:0003743)3.22952341
18Myoglobinuria (HP:0002913)3.19120511
19Fat malabsorption (HP:0002630)3.15256296
20Steatorrhea (HP:0002570)3.08588296
21Gonadotropin excess (HP:0000837)3.06827764
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.02507498
23Absent/shortened dynein arms (HP:0200106)3.02507498
24Abnormal ciliary motility (HP:0012262)3.01010463
25Xanthomatosis (HP:0000991)2.97614999
26Exercise-induced muscle cramps (HP:0003710)2.92435803
27Abnormality of aromatic amino acid family metabolism (HP:0004338)2.91207588
28Calf muscle hypertrophy (HP:0008981)2.87962467
29Abnormality of the calf musculature (HP:0001430)2.85017716
30Complement deficiency (HP:0004431)2.82811811
31True hermaphroditism (HP:0010459)2.81461697
32Premature rupture of membranes (HP:0001788)2.81159270
33Round ear (HP:0100830)2.81098265
34Areflexia of lower limbs (HP:0002522)2.80623309
35Abnormality of binocular vision (HP:0011514)2.78984534
36Diplopia (HP:0000651)2.78984534
37Hypoalphalipoproteinemia (HP:0003233)2.78776380
38Pancreatic fibrosis (HP:0100732)2.76035180
39Prolonged partial thromboplastin time (HP:0003645)2.74466605
40Pancreatic cysts (HP:0001737)2.72523782
41Hyperglycinuria (HP:0003108)2.72430857
42Hyperkalemia (HP:0002153)2.68841679
43Distal lower limb muscle weakness (HP:0009053)2.66714265
44Increased connective tissue (HP:0009025)2.64779019
45Hypoplasia of the uterus (HP:0000013)2.62736046
46Febrile seizures (HP:0002373)2.62497178
47Clumsiness (HP:0002312)2.61780131
48Cystic liver disease (HP:0006706)2.58591406
49Bifid scrotum (HP:0000048)2.56606366
50Fragile skin (HP:0001030)2.56323366
51Abnormal sex determination (HP:0012244)2.54442483
52Sex reversal (HP:0012245)2.54442483
53Abnormality of the intrinsic pathway (HP:0010989)2.54321947
54Ankle contracture (HP:0006466)2.53248428
55Aortic aneurysm (HP:0004942)2.53222610
56Lip pit (HP:0100267)2.51862545
57Testicular neoplasm (HP:0010788)2.51677207
58Stomach cancer (HP:0012126)2.51527224
59Rhabdomyolysis (HP:0003201)2.47927562
60Pulmonary artery stenosis (HP:0004415)2.47272267
61Progressive cerebellar ataxia (HP:0002073)2.47223873
62Abnormal respiratory motile cilium physiology (HP:0012261)2.46885623
63Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.46296919
64Abnormal respiratory epithelium morphology (HP:0012253)2.45909421
65Abnormal respiratory motile cilium morphology (HP:0005938)2.45909421
66Abnormality of fatty-acid metabolism (HP:0004359)2.45882761
67Abnormality of the distal phalanges of the toes (HP:0010182)2.45608464
68Hyperammonemia (HP:0001987)2.44267436
69Follicular hyperkeratosis (HP:0007502)2.44176121
70Papilledema (HP:0001085)2.44076957
71Sudden death (HP:0001699)2.42514795
72Nausea (HP:0002018)2.41919047
73Osteolytic defects of the hand bones (HP:0009699)2.41661952
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.41661952
75Myocardial infarction (HP:0001658)2.40591425
76Ketosis (HP:0001946)2.38500437
77Hypolipoproteinemia (HP:0010981)2.37712061
78Abnormality of the renal medulla (HP:0100957)2.34759732
79Nephronophthisis (HP:0000090)2.34748573
80Asymmetric septal hypertrophy (HP:0001670)2.33923254
81Azoospermia (HP:0000027)2.33867097
82Gaze-evoked nystagmus (HP:0000640)2.33374489
83Bundle branch block (HP:0011710)2.33234355
84Abnormal cartilage morphology (HP:0002763)2.31865476
85Hypoglycemic coma (HP:0001325)2.29749354
86Increased variability in muscle fiber diameter (HP:0003557)2.29271766
87Myotonia (HP:0002486)2.28882026
88Hyperventilation (HP:0002883)2.28055125
89Difficulty running (HP:0009046)2.27499166
90Abnormality of the ischium (HP:0003174)2.26655047
91Preauricular pit (HP:0004467)2.26363147
92Periauricular skin pits (HP:0100277)2.26363147
93EMG: myopathic abnormalities (HP:0003458)2.25865154
94Congenital hepatic fibrosis (HP:0002612)2.25573304
95Focal motor seizures (HP:0011153)2.25531440
96Hypoplastic ischia (HP:0003175)2.24761817
97Focal seizures (HP:0007359)2.24482429
98Epidermoid cyst (HP:0200040)2.24022510
99Alopecia of scalp (HP:0002293)2.22899794
100Steppage gait (HP:0003376)2.22797146
101Cardiovascular calcification (HP:0011915)2.22663875
102Ketoacidosis (HP:0001993)2.22609530
103Neck muscle weakness (HP:0000467)2.21369809
104Abnormality of complement system (HP:0005339)2.20609306
105Mesangial abnormality (HP:0001966)2.19937205
106Facial diplegia (HP:0001349)2.19888041
107Hypobetalipoproteinemia (HP:0003563)2.19118761
108Ulnar deviation of the wrist (HP:0003049)2.18652823
109Polycythemia (HP:0001901)2.18621806
110Abnormality of skeletal muscle fiber size (HP:0012084)2.18364034
111EMG: neuropathic changes (HP:0003445)2.18356447
112Polydipsia (HP:0001959)2.16403619
113Abnormal drinking behavior (HP:0030082)2.16403619
114Hepatocellular carcinoma (HP:0001402)2.16090856
115Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.15980178
116Decreased circulating renin level (HP:0003351)2.14588823
117Abnormality of glycine metabolism (HP:0010895)2.14564309
118Abnormality of serine family amino acid metabolism (HP:0010894)2.14564309
119Absent phalangeal crease (HP:0006109)2.14211727
120Central scotoma (HP:0000603)2.12699669
121Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11212628
122Renal tubular acidosis (HP:0001947)2.10901391
123Attenuation of retinal blood vessels (HP:0007843)2.10416391
124Abnormality of the renal cortex (HP:0011035)2.10343648
125Hyperlipoproteinemia (HP:0010980)2.09207996
126Palpitations (HP:0001962)2.08458842
127Prolonged QT interval (HP:0001657)2.08191902
128Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07872720
129Abnormality of male internal genitalia (HP:0000022)2.07382430
130Proximal tubulopathy (HP:0000114)2.06602436
131Hip contracture (HP:0003273)2.06424201
132Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.05970166
133Congenital stationary night blindness (HP:0007642)2.05125004
134Vascular calcification (HP:0004934)2.03054462
135Stridor (HP:0010307)2.02449093
136Abnormality of potassium homeostasis (HP:0011042)2.01540527
137Chronic hepatic failure (HP:0100626)2.01214479
138Abnormality of the common coagulation pathway (HP:0010990)1.98363944
139Bell-shaped thorax (HP:0001591)1.97881878
140Medial flaring of the eyebrow (HP:0010747)1.97602087
141Short hallux (HP:0010109)1.97462417
142Abnormality of sulfur amino acid metabolism (HP:0004339)1.96832708
143Abnormality of glutamine family amino acid metabolism (HP:0010902)1.96567928
144Syncope (HP:0001279)1.96428674
145Postural instability (HP:0002172)1.96104052
146Spinal rigidity (HP:0003306)1.95831187
147Gait imbalance (HP:0002141)1.95761909
148Humeroradial synostosis (HP:0003041)1.95232380
149Synostosis involving the elbow (HP:0003938)1.95232380
150Short nail (HP:0001799)1.94922197
151Hyporeflexia of lower limbs (HP:0002600)1.94755368
152Hypoplasia of the iris (HP:0007676)1.94522284
153Esophageal varix (HP:0002040)1.94502530
154Lymphangioma (HP:0100764)1.94344706
155Type 1 muscle fiber predominance (HP:0003803)1.94281201
156Difficulty walking (HP:0002355)1.94038725
157Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93949729
158Atonic seizures (HP:0010819)1.93803638
159Neoplasm of the heart (HP:0100544)1.93694366
160Aortic dissection (HP:0002647)1.93350205
161Hypoplastic left heart (HP:0004383)1.93244303
162Atrophic scars (HP:0001075)1.92247860
163Redundant skin (HP:0001582)1.91763103
164Centrally nucleated skeletal muscle fibers (HP:0003687)1.91359314
165Cerebral palsy (HP:0100021)1.90624821
166Hypokalemia (HP:0002900)1.89882224
167Atrial fibrillation (HP:0005110)1.89258585
168Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88231019
169Systemic lupus erythematosus (HP:0002725)1.87893477
170Hyperglycinemia (HP:0002154)1.87425380
171Rectal prolapse (HP:0002035)1.87156639
172Heart block (HP:0012722)1.86554223
173Joint hemorrhage (HP:0005261)1.85073598
174Congenital primary aphakia (HP:0007707)1.84874820
175Aplasia/Hypoplasia of the hallux (HP:0008362)1.84397194
176Dialeptic seizures (HP:0011146)1.84150040
177Absent speech (HP:0001344)1.84038703
178Absence seizures (HP:0002121)1.83398709
179Limited hip movement (HP:0008800)1.83304046
180Molar tooth sign on MRI (HP:0002419)1.83217367
181Abnormality of midbrain morphology (HP:0002418)1.83217367
182Rickets (HP:0002748)1.82922223
183Bile duct proliferation (HP:0001408)1.80629601
184Abnormal biliary tract physiology (HP:0012439)1.80629601
185Nephritis (HP:0000123)1.80619037
186Hypercholesterolemia (HP:0003124)1.80286320
187Alveolar cell carcinoma (HP:0006519)1.79303362
188Ventricular tachycardia (HP:0004756)1.79295824
189Hemiparesis (HP:0001269)1.78589566
190Gowers sign (HP:0003391)1.78562157
191Subaortic stenosis (HP:0001682)1.77435391
192Abnormality of the left ventricular outflow tract (HP:0011103)1.77435391
193Bronchomalacia (HP:0002780)1.77340452
194Mitral stenosis (HP:0001718)1.77011720
195Broad metatarsal (HP:0001783)1.76764464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.86254846
2OBSCN3.71142086
3ERN13.29385541
4RIPK13.28028322
5MYLK3.06159706
6MAP3K32.89188855
7TAOK32.81099319
8TRIB32.60293258
9LATS12.48491457
10MAP3K72.35361040
11EPHB22.32194079
12ZAK2.25462497
13TESK12.23333830
14PHKG22.06796087
15PHKG12.06796087
16TTN1.99333824
17MAP2K21.93040659
18STK38L1.78521676
19SIK11.75769803
20PTK61.75507751
21PKN21.71774262
22FRK1.62511759
23KIT1.61076139
24FER1.60116732
25EPHB11.58219514
26MAP2K31.57582756
27MAPK151.50460311
28BMPR1B1.48688725
29RPS6KB21.45412286
30NTRK31.45223666
31EPHA31.41642370
32MAP3K21.34798709
33MAPK131.34121378
34PDGFRA1.33640315
35DAPK21.32364485
36FES1.31894405
37ACVR1B1.29404568
38PDK21.28402042
39MAPKAPK31.28398238
40LMTK21.28021174
41FGFR41.27698354
42MAP4K11.23016424
43MAP4K21.18353054
44RPS6KA41.16353847
45PRKAA21.13523729
46PDK31.11941682
47PDK41.11941682
48WNK31.11332233
49DMPK1.11089996
50ADRBK21.10320084
51NUAK11.09638983
52LIMK11.09256649
53MST1R1.08599628
54CAMK11.07463759
55STK381.05833521
56TYRO31.05684715
57MAPK121.05461929
58LATS21.03668129
59PAK31.02792753
60PBK1.01606472
61MET0.97275350
62ADRBK10.96176003
63AKT30.95818697
64PKN10.92551061
65NEK90.91695162
66EPHA20.91324724
67MAP2K10.90120200
68STK30.87922934
69MAP2K60.87771575
70PTK2B0.87466077
71GRK50.87098184
72MARK20.86203050
73TEC0.85267035
74INSRR0.85085644
75MUSK0.84244254
76ERBB20.83856889
77MAP3K110.83648810
78TAOK20.81484020
79ERBB40.80769448
80GSK3A0.79817936
81SGK30.79514201
82FGFR20.78352738
83PAK20.77395451
84MARK10.77292497
85CAMK1D0.77012689
86ERBB30.76789161
87EPHA40.76565404
88MST40.75614629
89DDR20.73798392
90BTK0.73398922
91DYRK1A0.73097186
92CHUK0.72625683
93NME10.71863566
94ROCK10.71461676
95SGK20.71351576
96GRK10.71269502
97CDK60.70630092
98STK40.69783234
99PIK3CA0.69305862
100TIE10.69300385
101FLT30.68787070
102MAP3K60.68723117
103PRKAA10.68108134
104NLK0.67989969
105NTRK20.67450986
106PRKD20.66961973
107CDC42BPA0.66640017
108PTK20.66287499
109PAK40.64656376
110PINK10.63131461
111PIK3CG0.62937694
112HCK0.62143735
113PRKD30.62134440
114MAPK70.61151491
115TAOK10.61040778
116DYRK1B0.60887770
117IKBKE0.60034004
118TNK20.59785624
119HIPK20.59608365
120TRPM70.59259601
121PDGFRB0.58486073
122ITK0.58024829
123WNK40.57886551
124CAMK2A0.56658867
125PRKCH0.56386252
126JAK10.56292702
127PRKG10.56109864
128TGFBR20.55305781
129SYK0.55268827
130ILK0.54251747
131PRKCE0.54241892
132MTOR0.53538264
133CDK70.52495590
134ZAP700.52111477
135LRRK20.51896651
136IRAK30.51700005
137TNIK0.51102421
138BRD40.50980664
139FGFR30.49844191
140CAMK40.49319435
141JAK30.47723325
142TGFBR10.46970034
143MAP2K40.46897080
144BMPR20.46250616
145PRKD10.45803306
146CDK30.45346399
147MARK30.45311461
148CDK120.44829984
149WNK10.44336423
150MAPKAPK50.44270376
151CDK190.44173846
152CAMKK10.44006434
153RPS6KA60.43952430
154MAP3K130.43481205
155MAPK40.42624777
156BMX0.42359293
157SGK2230.41976385
158SGK4940.41976385
159RPS6KC10.40832231
160RPS6KL10.40832231
161JAK20.40271144
162PRKACA0.39931755
163MAPK30.38205074
164RPS6KA20.36952746

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.02964439
2Pentose and glucuronate interconversions_Homo sapiens_hsa000403.86412325
3* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.76275795
4* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.72742937
5* Chemical carcinogenesis_Homo sapiens_hsa052043.34890254
6Steroid hormone biosynthesis_Homo sapiens_hsa001403.21962370
7Sulfur metabolism_Homo sapiens_hsa009202.95333161
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.55069106
9Fatty acid degradation_Homo sapiens_hsa000712.27062834
10* Glutathione metabolism_Homo sapiens_hsa004802.15210859
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14971847
12Propanoate metabolism_Homo sapiens_hsa006401.98954034
13Starch and sucrose metabolism_Homo sapiens_hsa005001.95245255
14Caffeine metabolism_Homo sapiens_hsa002321.92844989
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.90793896
16Retinol metabolism_Homo sapiens_hsa008301.88720054
17Tryptophan metabolism_Homo sapiens_hsa003801.82062393
18Sulfur relay system_Homo sapiens_hsa041221.80408174
19Calcium signaling pathway_Homo sapiens_hsa040201.79004218
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77958084
21Circadian entrainment_Homo sapiens_hsa047131.76165626
22Fatty acid metabolism_Homo sapiens_hsa012121.75829033
23Salivary secretion_Homo sapiens_hsa049701.75689458
24Complement and coagulation cascades_Homo sapiens_hsa046101.72886399
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72416966
26Renin secretion_Homo sapiens_hsa049241.71608634
27Butanoate metabolism_Homo sapiens_hsa006501.68477031
28beta-Alanine metabolism_Homo sapiens_hsa004101.67016272
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.63821460
30Dilated cardiomyopathy_Homo sapiens_hsa054141.62682241
31PPAR signaling pathway_Homo sapiens_hsa033201.61741184
32Oxytocin signaling pathway_Homo sapiens_hsa049211.47662721
33Olfactory transduction_Homo sapiens_hsa047401.44656446
34Peroxisome_Homo sapiens_hsa041461.44326667
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.41590463
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39258493
37Phototransduction_Homo sapiens_hsa047441.38787767
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36568413
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36369515
40Platelet activation_Homo sapiens_hsa046111.34485606
41Gastric acid secretion_Homo sapiens_hsa049711.33191116
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31956633
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29807199
44Insulin secretion_Homo sapiens_hsa049111.29171951
45Arginine biosynthesis_Homo sapiens_hsa002201.26565098
46Taste transduction_Homo sapiens_hsa047421.26552101
47Histidine metabolism_Homo sapiens_hsa003401.25706066
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24165425
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20973831
50Phenylalanine metabolism_Homo sapiens_hsa003601.20822721
51Nitrogen metabolism_Homo sapiens_hsa009101.18138761
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.17321197
53Morphine addiction_Homo sapiens_hsa050321.16345106
54Fat digestion and absorption_Homo sapiens_hsa049751.16198650
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16186450
56Glutamatergic synapse_Homo sapiens_hsa047241.13685590
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12070605
58Selenocompound metabolism_Homo sapiens_hsa004501.08483616
59Pyruvate metabolism_Homo sapiens_hsa006201.08314681
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07097163
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06066867
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02737572
63Ether lipid metabolism_Homo sapiens_hsa005651.01579503
64GABAergic synapse_Homo sapiens_hsa047271.01565749
65Asthma_Homo sapiens_hsa053101.01120818
66Galactose metabolism_Homo sapiens_hsa000521.00410511
67Graft-versus-host disease_Homo sapiens_hsa053320.98188729
68cAMP signaling pathway_Homo sapiens_hsa040240.96321177
69Serotonergic synapse_Homo sapiens_hsa047260.96156211
70Tyrosine metabolism_Homo sapiens_hsa003500.95285908
71Glycerolipid metabolism_Homo sapiens_hsa005610.89277845
72Vitamin digestion and absorption_Homo sapiens_hsa049770.89084094
73Bile secretion_Homo sapiens_hsa049760.88695804
74Cholinergic synapse_Homo sapiens_hsa047250.88367688
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88203652
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.88199290
77Nicotine addiction_Homo sapiens_hsa050330.88125757
78Long-term depression_Homo sapiens_hsa047300.88098976
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87556221
80Fatty acid elongation_Homo sapiens_hsa000620.84985189
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.83778477
82Amphetamine addiction_Homo sapiens_hsa050310.82870358
83Glucagon signaling pathway_Homo sapiens_hsa049220.82785883
84Carbon metabolism_Homo sapiens_hsa012000.82436641
85Allograft rejection_Homo sapiens_hsa053300.81685693
86Protein digestion and absorption_Homo sapiens_hsa049740.80017403
87Autoimmune thyroid disease_Homo sapiens_hsa053200.79302423
88Arginine and proline metabolism_Homo sapiens_hsa003300.77498956
89Fatty acid biosynthesis_Homo sapiens_hsa000610.77478304
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76725736
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75890587
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75572947
93Dorso-ventral axis formation_Homo sapiens_hsa043200.75465572
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75126758
95ABC transporters_Homo sapiens_hsa020100.74826630
96ECM-receptor interaction_Homo sapiens_hsa045120.74237569
97Choline metabolism in cancer_Homo sapiens_hsa052310.71683197
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69967770
99Type I diabetes mellitus_Homo sapiens_hsa049400.67050785
100Lysine degradation_Homo sapiens_hsa003100.66281146
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65586208
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63152857
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.62392396
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61750747
105Long-term potentiation_Homo sapiens_hsa047200.59841329
106Inositol phosphate metabolism_Homo sapiens_hsa005620.58811829
107Biosynthesis of amino acids_Homo sapiens_hsa012300.58723413
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.58338284
109Folate biosynthesis_Homo sapiens_hsa007900.57514354
110Insulin resistance_Homo sapiens_hsa049310.57480734
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54746868
112Staphylococcus aureus infection_Homo sapiens_hsa051500.53708732
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52846128
114Cocaine addiction_Homo sapiens_hsa050300.52754648
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52215967
116Dopaminergic synapse_Homo sapiens_hsa047280.51942517
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51931642
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50750159
119Ovarian steroidogenesis_Homo sapiens_hsa049130.49705198
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.49475672
121Viral myocarditis_Homo sapiens_hsa054160.49350866
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49186467
123TGF-beta signaling pathway_Homo sapiens_hsa043500.48506590
124Amoebiasis_Homo sapiens_hsa051460.48090916
125Regulation of autophagy_Homo sapiens_hsa041400.47716161
126GnRH signaling pathway_Homo sapiens_hsa049120.47213666
127Ras signaling pathway_Homo sapiens_hsa040140.45685847
128Prion diseases_Homo sapiens_hsa050200.45407134
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44543701
130Arachidonic acid metabolism_Homo sapiens_hsa005900.44497605
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.43774125
132Adherens junction_Homo sapiens_hsa045200.43650421
133Mineral absorption_Homo sapiens_hsa049780.42088022
134Other glycan degradation_Homo sapiens_hsa005110.39719355
135MAPK signaling pathway_Homo sapiens_hsa040100.39158807
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38518794
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.38160041
138Focal adhesion_Homo sapiens_hsa045100.36459979
139Circadian rhythm_Homo sapiens_hsa047100.34319883
140Tight junction_Homo sapiens_hsa045300.28793914
141Metabolic pathways_Homo sapiens_hsa011000.28110686
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27998321
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27857916
144Fructose and mannose metabolism_Homo sapiens_hsa000510.27623978
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25859946
146Linoleic acid metabolism_Homo sapiens_hsa005910.25236088
147Small cell lung cancer_Homo sapiens_hsa052220.24489334
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23416161
149Prostate cancer_Homo sapiens_hsa052150.23207225
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21965966
151Pentose phosphate pathway_Homo sapiens_hsa000300.21958232
152Steroid biosynthesis_Homo sapiens_hsa001000.20640442
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19994528
154Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19992086
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18599440
156AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17362806
157One carbon pool by folate_Homo sapiens_hsa006700.17074106
158Pancreatic secretion_Homo sapiens_hsa049720.15609576
159Hippo signaling pathway_Homo sapiens_hsa043900.14882826
160TNF signaling pathway_Homo sapiens_hsa046680.14414292

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