GSTM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.07495889
2* xenobiotic catabolic process (GO:0042178)8.86132102
3* response to nitrosative stress (GO:0051409)8.43279170
4drug catabolic process (GO:0042737)8.11895563
5epoxygenase P450 pathway (GO:0019373)7.87119295
6omega-hydroxylase P450 pathway (GO:0097267)7.37215210
7cellular glucuronidation (GO:0052695)7.33373387
8glucuronate metabolic process (GO:0019585)7.32380729
9uronic acid metabolic process (GO:0006063)7.32380729
10ethanol oxidation (GO:0006069)6.19791576
11drug metabolic process (GO:0017144)5.96538947
12regulation of skeletal muscle contraction (GO:0014819)5.74641079
13oxidative demethylation (GO:0070989)5.45261203
14sulfur amino acid catabolic process (GO:0000098)5.39587697
15ethanol metabolic process (GO:0006067)5.11955135
16one-carbon compound transport (GO:0019755)5.06890890
17* benzene-containing compound metabolic process (GO:0042537)5.03977899
18fibrinolysis (GO:0042730)4.91783011
19regulation of cholesterol biosynthetic process (GO:0045540)4.87405744
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.83742956
21fat-soluble vitamin biosynthetic process (GO:0042362)4.83438617
22* glutathione derivative metabolic process (GO:1901685)4.69986074
23* glutathione derivative biosynthetic process (GO:1901687)4.69986074
24hormone catabolic process (GO:0042447)4.67554973
25coenzyme catabolic process (GO:0009109)4.59859741
26cellular ketone body metabolic process (GO:0046950)4.53991911
27regulation of cholesterol esterification (GO:0010872)4.48094164
28high-density lipoprotein particle remodeling (GO:0034375)4.41445580
29L-phenylalanine catabolic process (GO:0006559)4.37652875
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.37652875
31L-ascorbic acid metabolic process (GO:0019852)4.27254965
32citrulline biosynthetic process (GO:0019240)4.25460607
33glycine metabolic process (GO:0006544)4.24174265
34low-density lipoprotein particle remodeling (GO:0034374)4.22990015
35alkaloid metabolic process (GO:0009820)4.22848431
36glyoxylate metabolic process (GO:0046487)4.22073072
37* glutathione metabolic process (GO:0006749)4.21321375
38S-adenosylmethionine metabolic process (GO:0046500)4.20375560
39aromatic amino acid family catabolic process (GO:0009074)4.16135070
40blood coagulation, intrinsic pathway (GO:0007597)4.15977587
41reverse cholesterol transport (GO:0043691)4.10729160
42renal absorption (GO:0070293)4.10348417
43alpha-linolenic acid metabolic process (GO:0036109)4.04080048
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.03764864
45L-phenylalanine metabolic process (GO:0006558)4.03764864
46bile acid and bile salt transport (GO:0015721)4.03470740
47indole-containing compound catabolic process (GO:0042436)4.02459560
48indolalkylamine catabolic process (GO:0046218)4.02459560
49tryptophan catabolic process (GO:0006569)4.02459560
50negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.01410121
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95866354
52ketone body metabolic process (GO:1902224)3.93389140
53vitamin biosynthetic process (GO:0009110)3.93044946
54bile acid biosynthetic process (GO:0006699)3.91008611
55arginine metabolic process (GO:0006525)3.84180242
56imidazole-containing compound metabolic process (GO:0052803)3.82716965
57regulation of bile acid biosynthetic process (GO:0070857)3.79852182
58relaxation of cardiac muscle (GO:0055119)3.78295239
59cysteine metabolic process (GO:0006534)3.74056028
60regulation of cholesterol metabolic process (GO:0090181)3.73749999
61tryptophan metabolic process (GO:0006568)3.73169067
62protein-lipid complex remodeling (GO:0034368)3.70937871
63macromolecular complex remodeling (GO:0034367)3.70937871
64plasma lipoprotein particle remodeling (GO:0034369)3.70937871
65energy homeostasis (GO:0097009)3.70919903
66phospholipid efflux (GO:0033700)3.70363930
67polyketide metabolic process (GO:0030638)3.69074163
68doxorubicin metabolic process (GO:0044598)3.69074163
69daunorubicin metabolic process (GO:0044597)3.69074163
70regulation of plasminogen activation (GO:0010755)3.66578650
71cofactor catabolic process (GO:0051187)3.65751003
72negative regulation of sterol transport (GO:0032372)3.64392116
73negative regulation of cholesterol transport (GO:0032375)3.64392116
74kynurenine metabolic process (GO:0070189)3.63393040
75monocarboxylic acid catabolic process (GO:0072329)3.50262562
76negative regulation of hemostasis (GO:1900047)3.47779396
77negative regulation of blood coagulation (GO:0030195)3.47779396
783-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.46300249
79purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.46300249
80amino acid salvage (GO:0043102)3.44751095
81L-methionine salvage (GO:0071267)3.44751095
82L-methionine biosynthetic process (GO:0071265)3.44751095
83serine family amino acid metabolic process (GO:0009069)3.41432556
84fatty acid catabolic process (GO:0009062)3.40683183
85negative regulation of lipase activity (GO:0060192)3.39543229
86positive regulation of steroid metabolic process (GO:0045940)3.38920058
87quinone metabolic process (GO:1901661)3.38535130
88acylglycerol homeostasis (GO:0055090)3.37283793
89triglyceride homeostasis (GO:0070328)3.37283793
90regulation of cholesterol homeostasis (GO:2000188)3.36604986
91flavonoid metabolic process (GO:0009812)3.36593722
92regulation of fibrinolysis (GO:0051917)3.35677692
93primary alcohol catabolic process (GO:0034310)3.35079939
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.32917699
95phospholipid homeostasis (GO:0055091)3.32654207
96polyol transport (GO:0015791)3.32647897
97aminoglycoside antibiotic metabolic process (GO:0030647)3.31963402
98phenylpropanoid metabolic process (GO:0009698)3.23342968
99response to mercury ion (GO:0046689)3.22239076
100amino-acid betaine metabolic process (GO:0006577)3.22112390
101androgen biosynthetic process (GO:0006702)3.22053717
102negative regulation of coagulation (GO:0050819)3.22043198
103bile acid metabolic process (GO:0008206)3.21572055
104heme transport (GO:0015886)3.19051602
105tyrosine metabolic process (GO:0006570)3.18147582
106ribosomal small subunit assembly (GO:0000028)3.17681159
107cellular biogenic amine catabolic process (GO:0042402)3.16927128
108amine catabolic process (GO:0009310)3.16927128
109homocysteine metabolic process (GO:0050667)3.16867571
110nucleotide transmembrane transport (GO:1901679)3.16779841
111* xenobiotic metabolic process (GO:0006805)3.13591172
112primary alcohol metabolic process (GO:0034308)3.13216125
113artery smooth muscle contraction (GO:0014824)3.12237561
114organic acid catabolic process (GO:0016054)3.12107755
115carboxylic acid catabolic process (GO:0046395)3.12107755
116cholesterol efflux (GO:0033344)3.11456212
117branched-chain amino acid metabolic process (GO:0009081)3.11028137
118urea metabolic process (GO:0019627)3.09681098
119urea cycle (GO:0000050)3.09681098
120positive regulation of steroid biosynthetic process (GO:0010893)3.09537923
121linoleic acid metabolic process (GO:0043651)3.06434376
122protein activation cascade (GO:0072376)3.06391936
123disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.05586486
124killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.05586486
125regulation of triglyceride catabolic process (GO:0010896)3.02690940
126aldehyde catabolic process (GO:0046185)3.02443011
127tonic smooth muscle contraction (GO:0014820)3.02072177
128response to caffeine (GO:0031000)3.01646985
129complement activation, alternative pathway (GO:0006957)3.00882345
130regulation of protein activation cascade (GO:2000257)2.98586031
131very-low-density lipoprotein particle assembly (GO:0034379)2.97715704
132plasma lipoprotein particle organization (GO:0071827)2.92758277
133sulfation (GO:0051923)2.90390260
134sulfate transmembrane transport (GO:1902358)2.89983287
135relaxation of muscle (GO:0090075)2.89310013
136protein carboxylation (GO:0018214)2.88273728
137peptidyl-glutamic acid carboxylation (GO:0017187)2.88273728
138response to dietary excess (GO:0002021)2.86670229
139L-serine metabolic process (GO:0006563)2.86608862
140negative regulation of fibrinolysis (GO:0051918)2.86320494
141cellular amino acid catabolic process (GO:0009063)2.85969134
142serine family amino acid catabolic process (GO:0009071)2.84892698
143aromatic amino acid family metabolic process (GO:0009072)2.84806326
144serine family amino acid biosynthetic process (GO:0009070)2.83758907
145drug transmembrane transport (GO:0006855)2.83607627
146nitrogen cycle metabolic process (GO:0071941)2.83298964
147acute-phase response (GO:0006953)2.82679791
148alpha-amino acid catabolic process (GO:1901606)2.79645634
149regulation of complement activation (GO:0030449)2.78337810
150regulation of secondary heart field cardioblast proliferation (GO:0003266)2.76206966
151regulation of cardioblast proliferation (GO:0003264)2.76206966
152peptide catabolic process (GO:0043171)2.76106472
153cellular modified amino acid catabolic process (GO:0042219)2.74072604
154toxin transport (GO:1901998)2.73244521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.62489886
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.34862101
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.34563946
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.59158248
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.51390414
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.37458841
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.74084799
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.66658986
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.47331077
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.27457425
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.18188595
12* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.94288379
13CLOCK_20551151_ChIP-Seq_293T_Human2.90467039
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.74886493
15EZH2_22144423_ChIP-Seq_EOC_Human2.15121500
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05605857
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.00161536
18IRF1_19129219_ChIP-ChIP_H3396_Human1.99019821
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97609593
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93735343
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93687840
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77548603
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77388218
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70936467
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.67201962
26HTT_18923047_ChIP-ChIP_STHdh_Human1.66009712
27* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.65324555
28* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.65324555
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.59159055
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.58602189
31NANOG_20526341_ChIP-Seq_ESCs_Human1.55398211
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53408042
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.50788503
34PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.49271667
35TAF15_26573619_Chip-Seq_HEK293_Human1.48216956
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.46185486
37MYC_19829295_ChIP-Seq_ESCs_Human1.44945871
38ZNF263_19887448_ChIP-Seq_K562_Human1.44836849
39TAF2_19829295_ChIP-Seq_ESCs_Human1.44001300
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42559909
41IGF1R_20145208_ChIP-Seq_DFB_Human1.41527263
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38704382
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37673963
44CBP_21632823_ChIP-Seq_H3396_Human1.37072254
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.37057911
46AR_20517297_ChIP-Seq_VCAP_Human1.36927740
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36716362
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33775290
49* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33486612
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.30894151
51SOX2_21211035_ChIP-Seq_LN229_Human1.29574249
52RAD21_21589869_ChIP-Seq_MESCs_Mouse1.28084204
53* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26247386
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25308028
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25093038
56* BCL6_27268052_Chip-Seq_Bcells_Human1.25038471
57SA1_27219007_Chip-Seq_Bcells_Human1.24614261
58* SRF_21415370_ChIP-Seq_HL-1_Mouse1.24167380
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23862235
60* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.22737859
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.22145618
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19755378
63* PHF8_20622853_ChIP-Seq_HELA_Human1.19682011
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19443595
65FOXH1_21741376_ChIP-Seq_ESCs_Human1.19241326
66* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.19018211
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18059424
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.17815023
69* FOXH1_21741376_ChIP-Seq_EPCs_Human1.17450313
70GATA6_21074721_ChIP-Seq_CACO-2_Human1.17130534
71CEBPB_22108803_ChIP-Seq_LS180_Human1.16984931
72ERG_20517297_ChIP-Seq_VCAP_Human1.16648390
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16380915
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15839039
75CTCF_27219007_Chip-Seq_Bcells_Human1.15418133
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14652768
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13749887
78SOX2_20726797_ChIP-Seq_SW620_Human1.10637347
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09183819
80NCOR_22424771_ChIP-Seq_293T_Human1.09013223
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08843453
82* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08042864
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07402348
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.06536474
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06409473
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.05704246
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05704246
88AR_21572438_ChIP-Seq_LNCaP_Human1.05427940
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04009607
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02232291
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01963943
92* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01458317
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00917908
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00613679
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00518026
96* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00249698
97NANOG_19829295_ChIP-Seq_ESCs_Human0.99079791
98SOX2_19829295_ChIP-Seq_ESCs_Human0.99079791
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99039254
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98889706
101GATA3_21878914_ChIP-Seq_MCF-7_Human0.98227553
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97350996
103FOXA2_19822575_ChIP-Seq_HepG2_Human0.96784038
104P300_27268052_Chip-Seq_Bcells_Human0.96709278
105ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96607979
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96394362
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96394362
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96394362
109FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96147763
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95990459
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95476057
112NFYA_21822215_ChIP-Seq_K562_Human0.95186258
113* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95145576
114CTCF_20526341_ChIP-Seq_ESCs_Human0.94893095
115CJUN_26792858_Chip-Seq_BT549_Human0.94504253
116TCF4_22108803_ChIP-Seq_LS180_Human0.94081064
117GATA4_25053715_ChIP-Seq_YYC3_Human0.93859163
118* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93300271
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93166100
120* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92493686
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.91889467
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91815759
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91792248
124GATA1_22025678_ChIP-Seq_K562_Human0.91292602
125EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91289785
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91134821
127P53_21459846_ChIP-Seq_SAOS-2_Human0.90485785
128CSB_26484114_Chip-Seq_FIBROBLAST_Human0.90328571
129AHR_22903824_ChIP-Seq_MCF-7_Human0.89672201
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88468394
131CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88307621
132STAT1_20625510_ChIP-Seq_HELA_Human0.87400733
133TP53_18474530_ChIP-ChIP_U2OS_Human0.86815434
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86063396
135* RBPJ_21746931_ChIP-Seq_IB4_Human0.84961546
136* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84493915
137GATA3_21867929_ChIP-Seq_CD8_Mouse0.84113665
138GATA2_21666600_ChIP-Seq_HMVEC_Human0.84093178
139PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84007766
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83535764
141CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83381802
142GATA3_24758297_ChIP-Seq_MCF-7_Human0.82546453
143* SPI1_20517297_ChIP-Seq_HL60_Human0.82436579
144HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82084464
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82047079
146E2F1_20622854_ChIP-Seq_HELA_Human0.79931913
147HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79731513
148BCAT_22108803_ChIP-Seq_LS180_Human0.79310611
149SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78502885
150KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78415011
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.77557065
152BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77367714
153SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76688096
154SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76688096
155FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74081459
156BP1_19119308_ChIP-ChIP_Hs578T_Human0.72371458
157TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72265604
158RXR_22108803_ChIP-Seq_LS180_Human0.71990574
159HNF4A_19822575_ChIP-Seq_HepG2_Human0.71745300
160ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71173182
161NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70651793
162TP63_23658742_ChIP-Seq_EP156T_Human0.69184639
163STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68435547
164VDR_24787735_ChIP-Seq_THP-1_Human0.67810974
165NR3C1_21868756_ChIP-Seq_MCF10A_Human0.67547485
166POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.67542935
167PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.66906964
168KLF5_25053715_ChIP-Seq_YYC3_Human0.65989115
169TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.65904813
170FOXA1_25552417_ChIP-Seq_VCAP_Human0.64661105
171CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.64580496
172AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.63773329
173IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.63539528
174* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.60793155
175TP53_20018659_ChIP-ChIP_R1E_Mouse0.59759207
176PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58840898
177SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.58608080
178SOX2_18555785_ChIP-Seq_MESCs_Mouse0.58576373
179ARNT_22903824_ChIP-Seq_MCF-7_Human0.58128201
180SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.58008647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.28044221
2MP0005365_abnormal_bile_salt4.87164329
3* MP0008875_abnormal_xenobiotic_pharmacok4.48708386
4MP0005085_abnormal_gallbladder_physiolo4.42225982
5MP0005360_urolithiasis4.33951977
6MP0008789_abnormal_olfactory_epithelium3.89543834
7MP0005367_renal/urinary_system_phenotyp3.73729822
8MP0000516_abnormal_urinary_system3.73729822
9MP0010386_abnormal_urinary_bladder3.69717439
10MP0005499_abnormal_olfactory_system3.23971928
11MP0005394_taste/olfaction_phenotype3.23971928
12MP0009840_abnormal_foam_cell3.13223891
13MP0003186_abnormal_redox_activity3.00597140
14MP0010329_abnormal_lipoprotein_level2.91700074
15MP0003806_abnormal_nucleotide_metabolis2.55214848
16MP0002877_abnormal_melanocyte_morpholog2.52820026
17MP0010030_abnormal_orbit_morphology2.51333131
18MP0002254_reproductive_system_inflammat2.46099571
19MP0005083_abnormal_biliary_tract2.28181494
20MP0010368_abnormal_lymphatic_system2.24432313
21MP0003252_abnormal_bile_duct2.20638970
22MP0005332_abnormal_amino_acid2.16097633
23MP0003690_abnormal_glial_cell2.14403816
24MP0000678_abnormal_parathyroid_gland2.01558366
25MP0003195_calcinosis1.99982798
26MP0004019_abnormal_vitamin_homeostasis1.98961291
27MP0002132_abnormal_respiratory_system1.94449636
28MP0003191_abnormal_cellular_cholesterol1.93833200
29MP0004043_abnormal_pH_regulation1.93691817
30MP0000566_synostosis1.90157317
31MP0009053_abnormal_anal_canal1.87184897
32MP0003868_abnormal_feces_composition1.67536630
33MP0001666_abnormal_nutrient_absorption1.62771975
34MP0002653_abnormal_ependyma_morphology1.49838042
35MP0002118_abnormal_lipid_homeostasis1.48540784
36MP0003724_increased_susceptibility_to1.42948498
37MP0005319_abnormal_enzyme/_coenzyme1.37024745
38MP0004142_abnormal_muscle_tone1.34109752
39MP0001764_abnormal_homeostasis1.31744857
40MP0005408_hypopigmentation1.29177925
41MP0006292_abnormal_olfactory_placode1.27714834
42MP0000609_abnormal_liver_physiology1.26462698
43MP0002837_dystrophic_cardiac_calcinosis1.24795823
44MP0001346_abnormal_lacrimal_gland1.24197891
45MP0002295_abnormal_pulmonary_circulatio1.22565147
46MP0000762_abnormal_tongue_morphology1.22121542
47MP0009379_abnormal_foot_pigmentation1.19944755
48MP0002233_abnormal_nose_morphology1.19897499
49MP0006036_abnormal_mitochondrial_physio1.16775679
50MP0002102_abnormal_ear_morphology1.16289740
51MP0005647_abnormal_sex_gland1.12774492
52MP0009643_abnormal_urine_homeostasis1.09748209
53MP0002090_abnormal_vision1.09046737
54MP0001501_abnormal_sleep_pattern1.08030341
55MP0001756_abnormal_urination1.07899924
56MP0003075_altered_response_to1.06839413
57MP0003705_abnormal_hypodermis_morpholog1.03624633
58MP0002249_abnormal_larynx_morphology1.02538810
59MP0009764_decreased_sensitivity_to1.02415151
60MP0005164_abnormal_response_to0.99498524
61MP0003879_abnormal_hair_cell0.98673688
62MP0005584_abnormal_enzyme/coenzyme_acti0.96829554
63MP0009785_altered_susceptibility_to0.94826516
64MP0004883_abnormal_blood_vessel0.93617278
65MP0002098_abnormal_vibrissa_morphology0.93414132
66MP0004782_abnormal_surfactant_physiolog0.93061074
67MP0005636_abnormal_mineral_homeostasis0.92442852
68MP0001661_extended_life_span0.92099367
69MP0003638_abnormal_response/metabolism_0.91575118
70MP0002876_abnormal_thyroid_physiology0.89998623
71MP0005084_abnormal_gallbladder_morpholo0.88438238
72MP0009763_increased_sensitivity_to0.87370706
73MP0002282_abnormal_trachea_morphology0.85778762
74MP0002138_abnormal_hepatobiliary_system0.85258571
75MP0000049_abnormal_middle_ear0.84867905
76MP0000534_abnormal_ureter_morphology0.84091276
77MP0009765_abnormal_xenobiotic_induced0.81890189
78MP0000613_abnormal_salivary_gland0.81112534
79MP0001986_abnormal_taste_sensitivity0.80871451
80MP0003878_abnormal_ear_physiology0.80149162
81MP0005377_hearing/vestibular/ear_phenot0.80149162
82MP0001853_heart_inflammation0.80100040
83MP0005248_abnormal_Harderian_gland0.78666736
84MP0004264_abnormal_extraembryonic_tissu0.78567186
85MP0006072_abnormal_retinal_apoptosis0.77820867
86MP0005646_abnormal_pituitary_gland0.76702112
87MP0003656_abnormal_erythrocyte_physiolo0.76390812
88* MP0008872_abnormal_physiological_respon0.76158377
89MP0003279_aneurysm0.76022740
90MP0003011_delayed_dark_adaptation0.75130754
91MP0005376_homeostasis/metabolism_phenot0.73708928
92MP0006082_CNS_inflammation0.73530431
93MP0005551_abnormal_eye_electrophysiolog0.72257794
94MP0005451_abnormal_body_composition0.70693473
95MP0001485_abnormal_pinna_reflex0.70462857
96MP0005166_decreased_susceptibility_to0.68014603
97MP0004885_abnormal_endolymph0.67679256
98MP0003453_abnormal_keratinocyte_physiol0.67417788
99MP0001984_abnormal_olfaction0.67000296
100MP0001440_abnormal_grooming_behavior0.65058816
101MP0002136_abnormal_kidney_physiology0.64883418
102MP0005023_abnormal_wound_healing0.64524652
103MP0003943_abnormal_hepatobiliary_system0.64255425
104MP0000598_abnormal_liver_morphology0.64083496
105MP0003436_decreased_susceptibility_to0.62799086
106MP0005671_abnormal_response_to0.61413991
107MP0005266_abnormal_metabolism0.61229001
108MP0001502_abnormal_circadian_rhythm0.59455510
109MP0000026_abnormal_inner_ear0.59158841
110MP0002928_abnormal_bile_duct0.57900530
111MP0001177_atelectasis0.57720887
112MP0004147_increased_porphyrin_level0.57510847
113MP0001963_abnormal_hearing_physiology0.57509903
114MP0002971_abnormal_brown_adipose0.57159373
115MP0002078_abnormal_glucose_homeostasis0.57027715
116MP0002060_abnormal_skin_morphology0.56871055
117MP0005670_abnormal_white_adipose0.54928721
118MP0005464_abnormal_platelet_physiology0.54608050
119MP0000604_amyloidosis0.54321634
120MP0009642_abnormal_blood_homeostasis0.52575246
121MP0008469_abnormal_protein_level0.52327970
122MP0001790_abnormal_immune_system0.51842295
123MP0005387_immune_system_phenotype0.51842295
124MP0001545_abnormal_hematopoietic_system0.50946124
125MP0005397_hematopoietic_system_phenotyp0.50946124
126MP0001835_abnormal_antigen_presentation0.50483556
127MP0009250_abnormal_appendicular_skeleto0.50403725
128MP0005535_abnormal_body_temperature0.49774270
129MP0009115_abnormal_fat_cell0.49727749
130MP0009697_abnormal_copulation0.49499491
131MP0009780_abnormal_chondrocyte_physiolo0.49299577
132MP0004742_abnormal_vestibular_system0.48755536
133MP0000230_abnormal_systemic_arterial0.48737909
134MP0001845_abnormal_inflammatory_respons0.48521167
135MP0002736_abnormal_nociception_after0.47750412
136MP0001800_abnormal_humoral_immune0.47059781
137MP0000685_abnormal_immune_system0.46428892
138* MP0001905_abnormal_dopamine_level0.46271113
139MP0000749_muscle_degeneration0.44214236
140MP0001542_abnormal_bone_strength0.44036977
141MP0005448_abnormal_energy_balance0.43951537
142MP0005025_abnormal_response_to0.41712764
143MP0001765_abnormal_ion_homeostasis0.41266924
144MP0005334_abnormal_fat_pad0.41136767

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)5.87323370
2Stomach cancer (HP:0012126)4.97343042
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.55957596
4Intrahepatic cholestasis (HP:0001406)4.52099488
5Deep venous thrombosis (HP:0002625)4.40468609
6Xanthomatosis (HP:0000991)4.32721119
7Fat malabsorption (HP:0002630)4.26407697
8Steatorrhea (HP:0002570)4.19512447
9Bifid scrotum (HP:0000048)4.12391791
10Prolonged partial thromboplastin time (HP:0003645)4.00893196
11Hyperlipoproteinemia (HP:0010980)3.74899700
12Lip pit (HP:0100267)3.71219508
13Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.66203590
14Epidermoid cyst (HP:0200040)3.53015628
15Synostosis involving the elbow (HP:0003938)3.50547564
16Humeroradial synostosis (HP:0003041)3.50547564
17Hyperglycinuria (HP:0003108)3.45089256
18Hypobetalipoproteinemia (HP:0003563)3.41122524
19Joint hemorrhage (HP:0005261)3.37088655
20Acute encephalopathy (HP:0006846)3.30487812
21Alveolar cell carcinoma (HP:0006519)3.28331435
22Cerebral edema (HP:0002181)3.26255263
23Abnormality of the middle phalanges of the toes (HP:0010183)3.25120995
24Complement deficiency (HP:0004431)3.19159765
25Abnormality of the phalanges of the 2nd finger (HP:0009541)3.16544224
26Acute necrotizing encephalopathy (HP:0006965)3.14538431
27Hypoglycemic coma (HP:0001325)3.12433306
28Abnormality of pyrimidine metabolism (HP:0004353)3.11717466
29Renal tubular acidosis (HP:0001947)3.10643441
30Hypoalphalipoproteinemia (HP:0003233)3.10528101
31Abnormality of urine glucose concentration (HP:0011016)3.07672873
32Glycosuria (HP:0003076)3.07672873
33Ketosis (HP:0001946)3.07009742
34Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.06840215
35Rickets (HP:0002748)3.05499189
36Hypolipoproteinemia (HP:0010981)3.00303849
37Abnormality of glycine metabolism (HP:0010895)2.99794452
38Abnormality of serine family amino acid metabolism (HP:0010894)2.99794452
39Mitochondrial inheritance (HP:0001427)2.98816923
40Hyperammonemia (HP:0001987)2.93654170
41Abnormal mitochondria in muscle tissue (HP:0008316)2.93151229
42Recurrent gram-negative bacterial infections (HP:0005420)2.92526279
43Hepatic necrosis (HP:0002605)2.91667628
44Reticulocytopenia (HP:0001896)2.89050370
45Neoplasm of the tracheobronchial system (HP:0100552)2.88923134
46Hepatocellular necrosis (HP:0001404)2.86650592
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.81285314
48Abnormality of sulfur amino acid metabolism (HP:0004339)2.77194124
49Abnormality of fatty-acid metabolism (HP:0004359)2.76300086
50Glomerulonephritis (HP:0000099)2.75422210
51Myocardial infarction (HP:0001658)2.75071398
52Abnormality of methionine metabolism (HP:0010901)2.74396886
53Lethargy (HP:0001254)2.72951309
54Hyperphosphaturia (HP:0003109)2.72797554
55Ketoacidosis (HP:0001993)2.72357738
56Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.71905794
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.71605732
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.71226640
59Dicarboxylic aciduria (HP:0003215)2.71226640
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.69622167
61Right ventricular cardiomyopathy (HP:0011663)2.69257314
62Proximal tubulopathy (HP:0000114)2.66423888
63Abnormality of the common coagulation pathway (HP:0010990)2.66118954
64Distal lower limb muscle weakness (HP:0009053)2.65814018
65Renal Fanconi syndrome (HP:0001994)2.60550453
66Systemic lupus erythematosus (HP:0002725)2.57145566
67Hyperglycinemia (HP:0002154)2.56347776
68Progressive macrocephaly (HP:0004481)2.53931101
69Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.53741464
703-Methylglutaconic aciduria (HP:0003535)2.50607031
71Hypercholesterolemia (HP:0003124)2.46116886
72Abnormality of complement system (HP:0005339)2.45479156
73Conjugated hyperbilirubinemia (HP:0002908)2.40395052
74Nephritis (HP:0000123)2.38440645
75Short hallux (HP:0010109)2.35373400
76Osteomalacia (HP:0002749)2.35110899
77Renal cortical cysts (HP:0000803)2.35022793
78Fibular aplasia (HP:0002990)2.33756603
79Lipid accumulation in hepatocytes (HP:0006561)2.33566257
80Aplasia involving bones of the extremities (HP:0009825)2.31300046
81Aplasia involving bones of the upper limbs (HP:0009823)2.31300046
82Aplasia of the phalanges of the hand (HP:0009802)2.31300046
83Abnormality of the phalanges of the 5th finger (HP:0004213)2.27590443
84Polycythemia (HP:0001901)2.26729760
85Prostate neoplasm (HP:0100787)2.26192247
86Delayed CNS myelination (HP:0002188)2.24707863
87Enlarged epiphyses (HP:0010580)2.24595292
88Increased CSF lactate (HP:0002490)2.24083531
89Abnormality of the distal phalanges of the toes (HP:0010182)2.23642791
90Abnormality of vitamin metabolism (HP:0100508)2.22209396
91Generalized aminoaciduria (HP:0002909)2.21319609
92Bile duct proliferation (HP:0001408)2.21068229
93Abnormal biliary tract physiology (HP:0012439)2.21068229
94Parakeratosis (HP:0001036)2.20830979
95Abnormal hemoglobin (HP:0011902)2.20779778
96Hepatocellular carcinoma (HP:0001402)2.19258091
97Increased muscle lipid content (HP:0009058)2.17793649
98Reduced antithrombin III activity (HP:0001976)2.16918031
99Aplasia/Hypoplasia of the hallux (HP:0008362)2.13283249
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10521089
101Oligomenorrhea (HP:0000876)2.09193335
102Esophageal varix (HP:0002040)2.07569237
103Hyperbilirubinemia (HP:0002904)2.07002351
104Alopecia of scalp (HP:0002293)2.06390392
105Amyloidosis (HP:0011034)2.04648524
106Hypophosphatemic rickets (HP:0004912)2.04385717
107Spastic diplegia (HP:0001264)2.03264229
108Spontaneous abortion (HP:0005268)2.02710062
109Vomiting (HP:0002013)2.02124477
110Vascular calcification (HP:0004934)2.01211407
111Femoral bowing (HP:0002980)1.99048890
112Macrocytic anemia (HP:0001972)1.99038562
113True hermaphroditism (HP:0010459)1.99001284
114Metabolic acidosis (HP:0001942)1.98993710
115Abnormality of the intrinsic pathway (HP:0010989)1.98884090
116Rhabdomyolysis (HP:0003201)1.98487330
117Hyperventilation (HP:0002883)1.98332376
118Purpura (HP:0000979)1.96938651
119Hypochromic microcytic anemia (HP:0004840)1.96678216
120Mitral stenosis (HP:0001718)1.95873669
121Irritability (HP:0000737)1.94925308
122Abnormal urine phosphate concentration (HP:0012599)1.94294386
123Pseudobulbar signs (HP:0002200)1.93871093
124Increased intramyocellular lipid droplets (HP:0012240)1.93010425
125Abnormality of purine metabolism (HP:0004352)1.92840057
126Flat acetabular roof (HP:0003180)1.92009595
127Methylmalonic acidemia (HP:0002912)1.91004514
128Increased hepatocellular lipid droplets (HP:0006565)1.90494766
129Abnormality of the 2nd finger (HP:0004100)1.89392241
130Stenosis of the external auditory canal (HP:0000402)1.88093023
131Abnormality of nucleobase metabolism (HP:0010932)1.87717359
132Pancreatitis (HP:0001733)1.87611490
133Gout (HP:0001997)1.87389055
134Abnormality of serum amino acid levels (HP:0003112)1.87271265
135Pancreatic fibrosis (HP:0100732)1.85827546
136Renal tubular dysfunction (HP:0000124)1.85494003
137Bowed forearm bones (HP:0003956)1.84740269
138Bowing of the arm (HP:0006488)1.84740269
139Mesomelia (HP:0003027)1.81981447
140Abnormal tarsal ossification (HP:0008369)1.80069018
141Tarsal synostosis (HP:0008368)1.79738199
142Cerebral palsy (HP:0100021)1.79316150
143Methylmalonic aciduria (HP:0012120)1.78671819
144Exertional dyspnea (HP:0002875)1.78429306
145Cardiovascular calcification (HP:0011915)1.72874084
146Abnormal pupillary function (HP:0007686)1.72654024
147Congenital, generalized hypertrichosis (HP:0004540)1.71765474
148Lactic acidosis (HP:0003128)1.71420475
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67196936
150Myoglobinuria (HP:0002913)1.65865488
151Pancreatic cysts (HP:0001737)1.64758380
152Increased serum pyruvate (HP:0003542)1.64242044
153Joint swelling (HP:0001386)1.64225649
154Opisthotonus (HP:0002179)1.62744805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.03852381
2ZAK3.71241996
3VRK23.58276963
4RIPK13.33511000
5MAP3K33.30484351
6MAPK152.90455033
7CDK192.76015744
8GRK52.36417136
9OBSCN2.32032526
10ERN12.29087024
11SIK12.25682714
12FRK2.23628813
13INSRR2.19118384
14MAP2K32.15340970
15EPHB12.10263924
16BRSK22.07090438
17NME12.06762641
18EPHB21.91145085
19VRK11.81945348
20ERBB41.76521328
21MAP3K141.76136155
22MAP3K21.73714797
23FGFR41.73143594
24SGK21.72005449
25MAP4K11.70979664
26EPHA31.69045147
27TAF11.67431810
28MAP3K121.65133879
29NLK1.62415423
30MST41.61427576
31HIPK21.58072067
32BMPR21.56471926
33NME21.55472337
34MAP2K21.53400466
35TAOK21.50669228
36STK161.46897260
37SGK31.45887304
38MYLK1.40898635
39DAPK31.39076815
40DYRK21.37902034
41TNIK1.32871533
42SGK4941.29154482
43SGK2231.29154482
44RPS6KB21.28118365
45RPS6KA41.26027369
46PINK11.21916388
47PBK1.21423154
48IKBKE1.18386592
49ARAF1.16092587
50ADRBK21.12218353
51KIT1.10204491
52CDK61.08469169
53TESK11.08446845
54IRAK31.04945558
55PDK21.03645654
56MAP4K21.02072988
57TAOK31.01318770
58TNK21.01180034
59MAPK71.00423864
60MST1R0.98901131
61MAP2K70.98155762
62DAPK10.97912190
63GSK3A0.97838989
64TXK0.95416994
65NEK60.95329838
66PRKCQ0.94590822
67CSF1R0.92890577
68LMTK20.91363429
69WNK30.91228524
70DYRK1B0.89119691
71NEK90.88487389
72MUSK0.88380023
73JAK10.86906629
74STK38L0.85701958
75ERBB20.85357594
76TYK20.85245647
77PHKG10.84413100
78PHKG20.84413100
79EPHA20.83837938
80CAMK40.82032619
81TLK10.79568271
82PAK30.78817234
83MAP2K60.75682977
84PTK60.74399608
85DDR20.73912150
86JAK20.73655297
87KDR0.73136158
88DAPK20.72679054
89JAK30.72030504
90MAPKAPK30.71926003
91LRRK20.71876423
92CHUK0.69935755
93MAP2K10.69845030
94IKBKB0.69644800
95LATS10.69526020
96MAPK120.68393499
97TAOK10.66593469
98IRAK40.66133776
99BRAF0.63295492
100PRKACA0.63079811
101MAP3K110.62636626
102WEE10.61177207
103STK40.60618911
104IGF1R0.59310258
105MAP2K40.59149710
106IRAK10.59128718
107RPS6KA60.58802382
108PRKCG0.57587745
109ADRBK10.57117208
110PRKACG0.56261200
111PRKG10.56056896
112FGFR20.55632060
113MAPK40.55299217
114STK100.54409481
115TTN0.53622356
116ABL20.53514133
117TBK10.53452525
118PIK3CG0.52010957
119STK380.51336314
120SYK0.50629247
121MAP3K40.49352626
122TGFBR10.49294188
123CAMK2G0.47164104
124FER0.47055326
125TIE10.46307801
126NUAK10.45559857
127MARK30.44999061
128RPS6KL10.43511543
129RPS6KC10.43511543
130PRKCA0.43470196
131ILK0.43171573
132AKT30.43109462
133PIM20.42684462
134MAP3K130.42674731
135LYN0.42132358
136MATK0.42108615
137PRKCD0.41611933
138MAPKAPK20.41208213
139RPS6KA20.41089761
140TEC0.40609197
141LIMK10.40559356
142PAK10.40289408
143MAP3K50.39571855
144EPHA40.38993026
145BRSK10.38783208
146CAMK10.37724206
147CDK90.37297286
148MOS0.37271209
149PRKCE0.37253449
150BMPR1B0.36944641
151AKT20.34111204
152MAPKAPK50.33725636
153MAP3K10.33648486
154ROCK10.33529519
155BTK0.31348182
156GRK10.31074176
157CSNK1A10.30445085
158ERBB30.29847481
159MAPK30.29426141
160MET0.26904882

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.45971386
2Pentose and glucuronate interconversions_Homo sapiens_hsa000404.17214279
3* Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.01871362
4* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.01546686
5* Chemical carcinogenesis_Homo sapiens_hsa052043.65399563
6Steroid hormone biosynthesis_Homo sapiens_hsa001403.34127890
7Primary bile acid biosynthesis_Homo sapiens_hsa001203.04132443
8Sulfur metabolism_Homo sapiens_hsa009202.96782864
9Nitrogen metabolism_Homo sapiens_hsa009102.57129695
10Retinol metabolism_Homo sapiens_hsa008302.07754898
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05297806
12* Glutathione metabolism_Homo sapiens_hsa004802.04824605
13Starch and sucrose metabolism_Homo sapiens_hsa005001.96829812
14Fatty acid degradation_Homo sapiens_hsa000711.96529268
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.92453496
16Tryptophan metabolism_Homo sapiens_hsa003801.85596200
17Sulfur relay system_Homo sapiens_hsa041221.83557171
18Butanoate metabolism_Homo sapiens_hsa006501.79306576
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78730893
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78176274
21Complement and coagulation cascades_Homo sapiens_hsa046101.78037585
22beta-Alanine metabolism_Homo sapiens_hsa004101.77203511
23Peroxisome_Homo sapiens_hsa041461.73945588
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.69147561
25Caffeine metabolism_Homo sapiens_hsa002321.68819281
26Histidine metabolism_Homo sapiens_hsa003401.60279040
27Propanoate metabolism_Homo sapiens_hsa006401.55500605
28Arginine biosynthesis_Homo sapiens_hsa002201.54309457
29Fatty acid metabolism_Homo sapiens_hsa012121.47411906
30PPAR signaling pathway_Homo sapiens_hsa033201.46288697
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39336607
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38754213
33Phenylalanine metabolism_Homo sapiens_hsa003601.36026977
34Oxidative phosphorylation_Homo sapiens_hsa001901.33689877
35Ribosome_Homo sapiens_hsa030101.28090448
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27840292
37Bile secretion_Homo sapiens_hsa049761.22144500
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.15954956
39Parkinsons disease_Homo sapiens_hsa050121.10975540
40Galactose metabolism_Homo sapiens_hsa000521.10105733
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03356812
42ABC transporters_Homo sapiens_hsa020100.97747056
43Selenocompound metabolism_Homo sapiens_hsa004500.97347097
44Tyrosine metabolism_Homo sapiens_hsa003500.95510824
45Steroid biosynthesis_Homo sapiens_hsa001000.91330259
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90049485
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89353673
48Staphylococcus aureus infection_Homo sapiens_hsa051500.88174308
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85018948
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84927287
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75474756
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72833242
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72540522
54Circadian rhythm_Homo sapiens_hsa047100.72033701
55Fatty acid elongation_Homo sapiens_hsa000620.70702828
56Vitamin digestion and absorption_Homo sapiens_hsa049770.68200889
57Proteasome_Homo sapiens_hsa030500.65291211
58Arginine and proline metabolism_Homo sapiens_hsa003300.64677992
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63993500
60Asthma_Homo sapiens_hsa053100.63632069
61Alzheimers disease_Homo sapiens_hsa050100.62896958
62Folate biosynthesis_Homo sapiens_hsa007900.62185366
63Pyruvate metabolism_Homo sapiens_hsa006200.60093769
64Prion diseases_Homo sapiens_hsa050200.59163899
65Fatty acid biosynthesis_Homo sapiens_hsa000610.57962367
66Glycerolipid metabolism_Homo sapiens_hsa005610.57331035
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57017172
68Carbon metabolism_Homo sapiens_hsa012000.56934573
69Biosynthesis of amino acids_Homo sapiens_hsa012300.54554005
70Fat digestion and absorption_Homo sapiens_hsa049750.54461219
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.50375286
72Huntingtons disease_Homo sapiens_hsa050160.50111203
73Allograft rejection_Homo sapiens_hsa053300.48979187
74Autoimmune thyroid disease_Homo sapiens_hsa053200.46866314
75Pentose phosphate pathway_Homo sapiens_hsa000300.46670816
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46154925
77African trypanosomiasis_Homo sapiens_hsa051430.44821279
78Ether lipid metabolism_Homo sapiens_hsa005650.44431042
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.39406349
80Lysine degradation_Homo sapiens_hsa003100.36510012
81Cardiac muscle contraction_Homo sapiens_hsa042600.36222205
82Insulin resistance_Homo sapiens_hsa049310.32058263
83Mineral absorption_Homo sapiens_hsa049780.30437863
84Rheumatoid arthritis_Homo sapiens_hsa053230.29975519
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28486944
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.27210054
87Metabolic pathways_Homo sapiens_hsa011000.27203524
88Protein export_Homo sapiens_hsa030600.27124598
89Systemic lupus erythematosus_Homo sapiens_hsa053220.26459915
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26224895
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.23655984
92Type I diabetes mellitus_Homo sapiens_hsa049400.23254528
93TNF signaling pathway_Homo sapiens_hsa046680.22197610
94Fructose and mannose metabolism_Homo sapiens_hsa000510.19275956
95Primary immunodeficiency_Homo sapiens_hsa053400.18254337
96RNA polymerase_Homo sapiens_hsa030200.16736069
97Pertussis_Homo sapiens_hsa051330.16236662
98Phototransduction_Homo sapiens_hsa047440.14323373
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.13895853
100One carbon pool by folate_Homo sapiens_hsa006700.11734631
101Pyrimidine metabolism_Homo sapiens_hsa002400.11132021
102Vitamin B6 metabolism_Homo sapiens_hsa007500.11123608
103Graft-versus-host disease_Homo sapiens_hsa053320.10066907
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.09006690
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08835972
106Malaria_Homo sapiens_hsa051440.07350532
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.06953142
108Serotonergic synapse_Homo sapiens_hsa047260.06748128
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04827372
110Pancreatic secretion_Homo sapiens_hsa049720.03375761
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.03272662
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.01781861
113Prostate cancer_Homo sapiens_hsa052150.01515941
114Arachidonic acid metabolism_Homo sapiens_hsa005900.01186324
115Amoebiasis_Homo sapiens_hsa051460.00973586
116Antigen processing and presentation_Homo sapiens_hsa046120.00920087
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.00426774
118Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0708979
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321-0.0693761
120Linoleic acid metabolism_Homo sapiens_hsa00591-0.0531756
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0415789
122Prolactin signaling pathway_Homo sapiens_hsa04917-0.0380460
123Legionellosis_Homo sapiens_hsa05134-0.0316864
124Hepatitis C_Homo sapiens_hsa05160-0.0236159
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0218732

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »