GSR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.60898590
2killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.60898590
3defense response to fungus (GO:0050832)5.25489176
4Golgi transport vesicle coating (GO:0048200)5.16189762
5COPI coating of Golgi vesicle (GO:0048205)5.16189762
6response to fungus (GO:0009620)4.89787954
7pentose-phosphate shunt (GO:0006098)4.80867094
8killing of cells of other organism (GO:0031640)4.58008924
9disruption of cells of other organism (GO:0044364)4.58008924
10respiratory burst (GO:0045730)4.56164232
11response to peptidoglycan (GO:0032494)4.55677827
12neutrophil mediated immunity (GO:0002446)4.53138765
13NADPH regeneration (GO:0006740)4.51963071
14leukocyte aggregation (GO:0070486)4.49904974
15proline biosynthetic process (GO:0006561)4.45235843
16reactive oxygen species biosynthetic process (GO:1903409)4.37611383
17glycosphingolipid catabolic process (GO:0046479)4.27641360
18neutrophil activation involved in immune response (GO:0002283)4.26153375
19daunorubicin metabolic process (GO:0044597)4.08858287
20polyketide metabolic process (GO:0030638)4.08858287
21doxorubicin metabolic process (GO:0044598)4.08858287
22hydrogen peroxide biosynthetic process (GO:0050665)4.07267654
23sequestering of metal ion (GO:0051238)4.03496006
24glycolipid catabolic process (GO:0019377)3.95911791
25protein localization to endosome (GO:0036010)3.88371855
26production of molecular mediator involved in inflammatory response (GO:0002532)3.88272428
27oligosaccharide catabolic process (GO:0009313)3.77449684
28regulation of translational fidelity (GO:0006450)3.72700178
29very-low-density lipoprotein particle assembly (GO:0034379)3.70112471
30leukocyte migration involved in inflammatory response (GO:0002523)3.68341124
31iron ion import (GO:0097286)3.67666954
32Arp2/3 complex-mediated actin nucleation (GO:0034314)3.58344905
33aminoglycoside antibiotic metabolic process (GO:0030647)3.57173217
34cellular extravasation (GO:0045123)3.54816548
35embryonic process involved in female pregnancy (GO:0060136)3.46405053
36glycoside metabolic process (GO:0016137)3.44775541
37pore complex assembly (GO:0046931)3.38186947
38myeloid leukocyte mediated immunity (GO:0002444)3.37816493
39negative regulation of phagocytosis (GO:0050765)3.36486207
40glucose catabolic process (GO:0006007)3.34412618
41ceramide catabolic process (GO:0046514)3.33064780
42modulation of growth of symbiont involved in interaction with host (GO:0044144)3.32614177
43regulation of growth of symbiont in host (GO:0044126)3.32614177
44negative regulation of growth of symbiont in host (GO:0044130)3.32614177
45negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.32614177
46neutrophil activation (GO:0042119)3.30739413
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27669209
48alpha-linolenic acid metabolic process (GO:0036109)3.27647427
49leukocyte mediated cytotoxicity (GO:0001909)3.27132373
50regulation of cholesterol homeostasis (GO:2000188)3.23012937
51COPII vesicle coating (GO:0048208)3.21360258
52macrophage differentiation (GO:0030225)3.19237651
53granulocyte activation (GO:0036230)3.17930575
54superoxide anion generation (GO:0042554)3.17191764
55positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.10721248
56pentose metabolic process (GO:0019321)3.10480643
57plasma lipoprotein particle assembly (GO:0034377)3.06539574
58NADP metabolic process (GO:0006739)3.04816197
59cell killing (GO:0001906)3.04364899
60regulation of early endosome to late endosome transport (GO:2000641)3.04134614
61glutamine family amino acid biosynthetic process (GO:0009084)3.01952041
62epithelial cell-cell adhesion (GO:0090136)3.00967596
63immunoglobulin mediated immune response (GO:0016064)2.99237130
64proline metabolic process (GO:0006560)2.97654868
65folic acid-containing compound biosynthetic process (GO:0009396)2.97114827
66antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94800343
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94800343
68NADH metabolic process (GO:0006734)2.94291171
69protein-lipid complex assembly (GO:0065005)2.93641235
70epithelial cell differentiation involved in prostate gland development (GO:0060742)2.89484193
71membrane lipid catabolic process (GO:0046466)2.86625389
72leukotriene metabolic process (GO:0006691)2.81821187
73vesicle coating (GO:0006901)2.77869246
74sphingolipid catabolic process (GO:0030149)2.77102356
75positive regulation of Cdc42 GTPase activity (GO:0043089)2.75241538
76B cell mediated immunity (GO:0019724)2.74740067
77response to thyroid hormone (GO:0097066)2.74464468
78regulation of cholesterol biosynthetic process (GO:0045540)2.71746282
79IMP metabolic process (GO:0046040)2.70240679
80positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.69078031
81mitotic chromosome condensation (GO:0007076)2.66852503
82progesterone metabolic process (GO:0042448)2.66082965
83intestinal absorption (GO:0050892)2.65469648
84positive regulation of keratinocyte differentiation (GO:0045618)2.63919398
85cellular response to thyroid hormone stimulus (GO:0097067)2.63232198
86branching involved in mammary gland duct morphogenesis (GO:0060444)2.61062157
87negative regulation of interleukin-12 production (GO:0032695)2.59980955
88regulation of RNA export from nucleus (GO:0046831)2.59320750
89cellular protein complex localization (GO:0034629)2.58240763
90regulation of translational termination (GO:0006449)2.57562403
91protein export from nucleus (GO:0006611)2.57444593
92regulation of cholesterol storage (GO:0010885)2.55737320
93DNA unwinding involved in DNA replication (GO:0006268)2.55673870
94cysteine metabolic process (GO:0006534)2.55336896
95glucose 6-phosphate metabolic process (GO:0051156)2.54937000
96low-density lipoprotein particle clearance (GO:0034383)2.53866129
97maternal placenta development (GO:0001893)2.53509870
98protein complex localization (GO:0031503)2.53298475
99negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.53125460
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52300919
101modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52300919
102positive regulation by organism of defense response of other organism involved in symbiotic interact2.52300919
103modulation by symbiont of host immune response (GO:0052553)2.52300919
104positive regulation by symbiont of host defense response (GO:0052509)2.52300919
105modulation by symbiont of host defense response (GO:0052031)2.52300919
106actin nucleation (GO:0045010)2.52216730
107response to arsenic-containing substance (GO:0046685)2.51587054
108IMP biosynthetic process (GO:0006188)2.51067265
109protein localization to kinetochore (GO:0034501)2.50170481
110angiotensin maturation (GO:0002003)2.50137626
111regulation of leukocyte degranulation (GO:0043300)2.49987054
112RNA stabilization (GO:0043489)2.49969560
113mRNA stabilization (GO:0048255)2.49969560
1143-UTR-mediated mRNA stabilization (GO:0070935)2.49503884
115regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49084626
116fructose metabolic process (GO:0006000)2.48805132
117mannose metabolic process (GO:0006013)2.48158475
118barbed-end actin filament capping (GO:0051016)2.47966284
119nitrogen cycle metabolic process (GO:0071941)2.47304841
120negative regulation of fatty acid biosynthetic process (GO:0045717)2.47035058
121antigen processing and presentation of endogenous antigen (GO:0019883)2.46622634
122activation of Rac GTPase activity (GO:0032863)2.46367774
123chronic inflammatory response (GO:0002544)2.44650888
124response to laminar fluid shear stress (GO:0034616)2.44029483
125regulation of vitamin metabolic process (GO:0030656)2.43069395
126neutrophil chemotaxis (GO:0030593)2.42486994
127activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41586360
128primary alcohol catabolic process (GO:0034310)2.41002844
129leukotriene biosynthetic process (GO:0019370)2.40590936
130regulation of superoxide anion generation (GO:0032928)2.40395766
131neutrophil migration (GO:1990266)2.40113393
132regulation of glucose import in response to insulin stimulus (GO:2001273)2.39367990
133leukocyte cell-cell adhesion (GO:0007159)2.38346220
134regulation of nucleobase-containing compound transport (GO:0032239)2.37536703
135maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.37483020
136monosaccharide biosynthetic process (GO:0046364)2.36840673
137pinocytosis (GO:0006907)2.35399198
138positive regulation of nuclease activity (GO:0032075)2.35320777
139response to host immune response (GO:0052572)2.35186408
140response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.35186408
141dicarboxylic acid biosynthetic process (GO:0043650)2.34333866
142cytoskeletal anchoring at plasma membrane (GO:0007016)2.34015301
143detection of other organism (GO:0098543)2.33359429
144nuclear pore complex assembly (GO:0051292)2.33228181
145response to muramyl dipeptide (GO:0032495)2.33085966
146regulation of mast cell activation (GO:0033003)2.32902289
147regulation of mast cell degranulation (GO:0043304)2.32307809
148ER-nucleus signaling pathway (GO:0006984)2.31942437
149protein retention in ER lumen (GO:0006621)2.31178406
150positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.30959597
151nucleotide-sugar biosynthetic process (GO:0009226)2.30802024
152positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.30236159
153nuclear pore organization (GO:0006999)2.30220656
154peptide catabolic process (GO:0043171)2.29992821
155DNA strand elongation involved in DNA replication (GO:0006271)2.29881079
156amyloid precursor protein catabolic process (GO:0042987)2.29072117
157hydrogen peroxide metabolic process (GO:0042743)2.28700295
158positive regulation of lamellipodium assembly (GO:0010592)2.28699024
159osteoclast differentiation (GO:0030316)2.28512456
160L-alpha-amino acid transmembrane transport (GO:1902475)2.27624213
161activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.27291432
162hepatocyte apoptotic process (GO:0097284)2.27083944
163endoplasmic reticulum unfolded protein response (GO:0030968)2.26664716
164natural killer cell mediated cytotoxicity (GO:0042267)2.26655102
165natural killer cell mediated immunity (GO:0002228)2.26655102
166tetrahydrofolate metabolic process (GO:0046653)2.26555844
167negative regulation of fatty acid transport (GO:2000192)2.26339754
168detection of bacterium (GO:0016045)2.26082869
169negative regulation of protein localization to plasma membrane (GO:1903077)2.25984012
170aldehyde catabolic process (GO:0046185)2.25401263
171regulation of chemokine biosynthetic process (GO:0045073)2.24959814
172interaction with symbiont (GO:0051702)2.23690127
173sulfur amino acid catabolic process (GO:0000098)2.23474668
174positive regulation of mast cell activation (GO:0033005)2.23426463
175regulation of cholesterol metabolic process (GO:0090181)2.23064558
176lipopolysaccharide-mediated signaling pathway (GO:0031663)2.22574569
177spliceosomal tri-snRNP complex assembly (GO:0000244)2.22486525
178regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.22063763
179* nucleobase-containing small molecule interconversion (GO:0015949)2.21097867
180DNA strand elongation (GO:0022616)2.19483667
181cellular response to zinc ion (GO:0071294)2.19384738
182regulation of interleukin-8 biosynthetic process (GO:0045414)2.17720682
183urea metabolic process (GO:0019627)2.16144067
184urea cycle (GO:0000050)2.16144067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.16832753
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.45158184
3MYB_21317192_ChIP-Seq_ERMYB_Mouse3.08290570
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.85626030
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81603948
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.76382003
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.75152237
8ZNF263_19887448_ChIP-Seq_K562_Human2.40195766
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38636176
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29751347
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.24808921
12BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13374254
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12880005
14VDR_21846776_ChIP-Seq_THP-1_Human2.10596981
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.07508825
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02524170
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01847465
18MYC_18555785_ChIP-Seq_MESCs_Mouse1.96904651
19SPI1_23547873_ChIP-Seq_NB4_Human1.92920822
20PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91412191
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89131850
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88173644
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87814759
24MYC_22102868_ChIP-Seq_BL_Human1.86477923
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84704592
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.83948382
27RACK7_27058665_Chip-Seq_MCF-7_Human1.80966636
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.80325076
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78621407
30* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.75197543
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74120217
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.73663149
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.69907606
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68054442
35KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.67839992
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67675299
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63747672
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61002835
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57197602
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54799660
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53914368
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.53258202
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.52679046
44GATA6_25053715_ChIP-Seq_YYC3_Human1.51703488
45VDR_24763502_ChIP-Seq_THP-1_Human1.48538346
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48420971
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47642201
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46668279
49* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46402285
50* AR_21909140_ChIP-Seq_LNCAP_Human1.46383530
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46073281
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43641231
53CHD1_26751641_Chip-Seq_LNCaP_Human1.41991180
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41821417
55* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40865370
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40016002
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38602618
58LXR_22292898_ChIP-Seq_THP-1_Human1.38213351
59MAF_26560356_Chip-Seq_TH1_Human1.37868690
60MYB_26560356_Chip-Seq_TH2_Human1.37356160
61GATA1_22025678_ChIP-Seq_K562_Human1.36937224
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36866345
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.36384919
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36044924
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35752280
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33462219
67* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33096654
68* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33083173
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32720022
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32607002
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32560026
72SCL_19346495_ChIP-Seq_HPC-7_Human1.31264076
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.30989760
74* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30977526
75* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30398654
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29273178
77* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28715217
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26001075
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25951472
80* UTX_26944678_Chip-Seq_JUKART_Human1.25778349
81* MYB_26560356_Chip-Seq_TH1_Human1.23595749
82* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23246934
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22429116
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21667556
85TFEB_21752829_ChIP-Seq_HELA_Human1.21177918
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19434749
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18050339
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17929205
89TCF7_22412390_ChIP-Seq_EML_Mouse1.15834980
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15662171
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14705052
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12849118
93* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12254912
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12134861
95* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11332657
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09502739
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08747426
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08511635
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07552025
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.07061615
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06441645
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06441645
103PU_27001747_Chip-Seq_BMDM_Mouse1.06143151
104* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05615136
105* RUNX1_27514584_Chip-Seq_MCF-7_Human1.04966881
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04901593
107KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04032162
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03078960
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02180374
110* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01658648
111NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01556096
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01226831
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01204601
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01056522
115XRN2_22483619_ChIP-Seq_HELA_Human1.00787412
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00360259
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99648749
118KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99608483
119ELK3_25401928_ChIP-Seq_HUVEC_Human0.98671990
120MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97839971
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97326818
122* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96621763
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96105528
124DCP1A_22483619_ChIP-Seq_HELA_Human0.95766663
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95080479
126GABP_17652178_ChIP-ChIP_JURKAT_Human0.95036419
127EST1_17652178_ChIP-ChIP_JURKAT_Human0.93985959
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93874727
129VDR_23849224_ChIP-Seq_CD4+_Human0.92832481
130SPI1_23127762_ChIP-Seq_K562_Human0.92809700
131CLOCK_20551151_ChIP-Seq_293T_Human0.92024642
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91705453
133KDM5A_27292631_Chip-Seq_BREAST_Human0.91235220
134E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91234706
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91033963
136KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91007476
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90798139
138MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89774507
139* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89060317
140NCOR1_26117541_ChIP-Seq_K562_Human0.88758354
141ATF3_27146783_Chip-Seq_COLON_Human0.88755188

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.67540131
2MP0003436_decreased_susceptibility_to3.42079357
3MP0003303_peritoneal_inflammation3.34302098
4MP0005360_urolithiasis2.65055746
5MP0009785_altered_susceptibility_to2.61435559
6MP0003806_abnormal_nucleotide_metabolis2.53673362
7MP0002419_abnormal_innate_immunity2.37112265
8MP0002139_abnormal_hepatobiliary_system2.24794905
9MP0009278_abnormal_bone_marrow2.19888234
10MP0003693_abnormal_embryo_hatching2.14235299
11MP0004233_abnormal_muscle_weight2.09321974
12MP0004185_abnormal_adipocyte_glucose2.08750279
13MP0005464_abnormal_platelet_physiology2.06586071
14MP0010352_gastrointestinal_tract_polyps2.03924847
15MP0005025_abnormal_response_to2.02716409
16MP0001835_abnormal_antigen_presentation1.96410871
17MP0003724_increased_susceptibility_to1.93888817
18MP0003186_abnormal_redox_activity1.90551223
19MP0009840_abnormal_foam_cell1.87787970
20MP0003183_abnormal_peptide_metabolism1.86393469
21MP0010307_abnormal_tumor_latency1.84744341
22MP0005397_hematopoietic_system_phenotyp1.83985822
23MP0001545_abnormal_hematopoietic_system1.83985822
24MP0003300_gastrointestinal_ulcer1.77913577
25MP0005058_abnormal_lysosome_morphology1.77366227
26MP0005076_abnormal_cell_differentiation1.76097429
27MP0005085_abnormal_gallbladder_physiolo1.66665558
28MP0000858_altered_metastatic_potential1.66550568
29MP0003191_abnormal_cellular_cholesterol1.65479603
30MP0001533_abnormal_skeleton_physiology1.64087154
31MP0002009_preneoplasia1.62904938
32MP0001853_heart_inflammation1.61393895
33MP0002148_abnormal_hypersensitivity_rea1.59899434
34MP0005000_abnormal_immune_tolerance1.59898364
35MP0001845_abnormal_inflammatory_respons1.58334784
36MP0005365_abnormal_bile_salt1.56674608
37MP0002396_abnormal_hematopoietic_system1.54506318
38MP0000343_altered_response_to1.53752501
39MP0010155_abnormal_intestine_physiology1.53090764
40MP0002405_respiratory_system_inflammati1.48725162
41MP0002452_abnormal_antigen_presenting1.48532851
42MP0000490_abnormal_crypts_of1.46880025
43MP0004957_abnormal_blastocyst_morpholog1.44865353
44MP0003566_abnormal_cell_adhesion1.44696391
45MP0008260_abnormal_autophagy1.43246802
46MP0000685_abnormal_immune_system1.42291841
47MP0009764_decreased_sensitivity_to1.41684574
48MP0004808_abnormal_hematopoietic_stem1.40399791
49MP0003705_abnormal_hypodermis_morpholog1.40065099
50MP0008469_abnormal_protein_level1.39785759
51MP0001819_abnormal_immune_cell1.39779986
52MP0001849_ear_inflammation1.39105256
53MP0002420_abnormal_adaptive_immunity1.39104567
54MP0004858_abnormal_nervous_system1.38120913
55MP0000604_amyloidosis1.36394639
56MP0003172_abnormal_lysosome_physiology1.36013848
57MP0002723_abnormal_immune_serum1.33703229
58MP0008057_abnormal_DNA_replication1.33538573
59MP0005023_abnormal_wound_healing1.30545696
60MP0003111_abnormal_nucleus_morphology1.30516310
61MP0001800_abnormal_humoral_immune1.30338488
62MP0002877_abnormal_melanocyte_morpholog1.29727422
63MP0005167_abnormal_blood-brain_barrier1.28822201
64MP0004947_skin_inflammation1.25840885
65MP0004264_abnormal_extraembryonic_tissu1.24407885
66MP0003448_altered_tumor_morphology1.22405231
67MP0010094_abnormal_chromosome_stability1.20901916
68MP0005319_abnormal_enzyme/_coenzyme1.20293047
69MP0003077_abnormal_cell_cycle1.18871869
70MP0008875_abnormal_xenobiotic_pharmacok1.18748851
71MP0010329_abnormal_lipoprotein_level1.17053495
72MP0003656_abnormal_erythrocyte_physiolo1.16681962
73MP0002398_abnormal_bone_marrow1.15931946
74MP0000609_abnormal_liver_physiology1.15630467
75MP0009333_abnormal_splenocyte_physiolog1.15587986
76MP0003075_altered_response_to1.15460119
77MP0000537_abnormal_urethra_morphology1.14369512
78MP0002796_impaired_skin_barrier1.13095787
79MP0000716_abnormal_immune_system1.12661504
80MP0003221_abnormal_cardiomyocyte_apopto1.12366464
81MP0010234_abnormal_vibrissa_follicle1.11846523
82MP0005387_immune_system_phenotype1.11788700
83MP0001790_abnormal_immune_system1.11788700
84MP0003091_abnormal_cell_migration1.09860987
85MP0003329_amyloid_beta_deposits1.09485404
86MP0000689_abnormal_spleen_morphology1.08231679
87MP0001661_extended_life_span1.07632617
88MP0002138_abnormal_hepatobiliary_system1.07323803
89MP0002429_abnormal_blood_cell1.07127912
90MP0002722_abnormal_immune_system1.06577955
91MP0005310_abnormal_salivary_gland1.05626497
92MP0010678_abnormal_skin_adnexa1.05567672
93MP0001727_abnormal_embryo_implantation1.04068728
94MP0002019_abnormal_tumor_incidence1.03601935
95MP0000465_gastrointestinal_hemorrhage1.03169562
96MP0003453_abnormal_keratinocyte_physiol1.02261705
97MP0005666_abnormal_adipose_tissue1.02013968
98MP0002166_altered_tumor_susceptibility1.01484426
99MP0006082_CNS_inflammation1.01213096
100MP0002006_tumorigenesis1.00797739
101MP0005409_darkened_coat_color1.00475997
102MP0009763_increased_sensitivity_to1.00166326
103MP0005083_abnormal_biliary_tract0.98799859
104MP0001873_stomach_inflammation0.98654686
105MP0002086_abnormal_extraembryonic_tissu0.97900527
106MP0000598_abnormal_liver_morphology0.97588528
107MP0002098_abnormal_vibrissa_morphology0.94649991
108MP0001764_abnormal_homeostasis0.94472396
109MP0005501_abnormal_skin_physiology0.93306880
110MP0003252_abnormal_bile_duct0.92074725
111MP0000747_muscle_weakness0.91500473
112MP0001851_eye_inflammation0.91133371
113MP0009643_abnormal_urine_homeostasis0.90399284
114MP0001666_abnormal_nutrient_absorption0.89152042
115MP0001730_embryonic_growth_arrest0.88914807
116MP0003984_embryonic_growth_retardation0.88520206
117MP0001672_abnormal_embryogenesis/_devel0.87750799
118MP0005380_embryogenesis_phenotype0.87750799
119MP0002080_prenatal_lethality0.86777438
120MP0000350_abnormal_cell_proliferation0.86580480
121MP0005332_abnormal_amino_acid0.86257140
122MP0005671_abnormal_response_to0.85412149
123MP0008007_abnormal_cellular_replicative0.85102775
124MP0002088_abnormal_embryonic_growth/wei0.84664947
125MP0000477_abnormal_intestine_morphology0.84508341
126MP0000627_abnormal_mammary_gland0.84465921
127MP0000678_abnormal_parathyroid_gland0.84181542
128MP0002998_abnormal_bone_remodeling0.84134168
129MP0001663_abnormal_digestive_system0.83904230
130MP0001216_abnormal_epidermal_layer0.83465840
131MP0005174_abnormal_tail_pigmentation0.82729324
132MP0005166_decreased_susceptibility_to0.82146526
133MP0001915_intracranial_hemorrhage0.82110444
134MP0004782_abnormal_surfactant_physiolog0.81836826
135MP0004019_abnormal_vitamin_homeostasis0.81531069
136MP0005621_abnormal_cell_physiology0.80736051
137MP0005408_hypopigmentation0.80309421
138MP0005248_abnormal_Harderian_gland0.78505721
139MP0000371_diluted_coat_color0.76611891
140MP0003868_abnormal_feces_composition0.75690729
141MP0003941_abnormal_skin_development0.75037667
142MP0002896_abnormal_bone_mineralization0.73791017
143MP0000313_abnormal_cell_death0.73553990
144MP0001697_abnormal_embryo_size0.70999321
145MP0009672_abnormal_birth_weight0.69412799

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.08390822
2Recurrent gram-negative bacterial infections (HP:0005420)6.49146286
3Recurrent abscess formation (HP:0002722)6.04961950
4Recurrent bacterial skin infections (HP:0005406)5.52310914
5Abnormality of macrophages (HP:0004311)4.39728940
6Obstructive lung disease (HP:0006536)4.06286494
7Chronic obstructive pulmonary disease (HP:0006510)4.06286494
8Mediastinal lymphadenopathy (HP:0100721)3.80531187
9Gingivitis (HP:0000230)3.74241356
10Abnormality of glycolipid metabolism (HP:0010969)3.67436137
11Abnormality of liposaccharide metabolism (HP:0010968)3.67436137
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.67436137
13Vacuolated lymphocytes (HP:0001922)3.35856231
14Recurrent fungal infections (HP:0002841)3.20713980
15Recurrent skin infections (HP:0001581)3.19036990
16Periodontitis (HP:0000704)3.14083501
17Urticaria (HP:0001025)3.13139449
18Asymmetry of the thorax (HP:0001555)3.12726728
19Flat acetabular roof (HP:0003180)3.11820402
20Cellulitis (HP:0100658)2.74032076
21Autoimmune thrombocytopenia (HP:0001973)2.73878165
22Thrombocytosis (HP:0001894)2.72895978
23Increased cerebral lipofuscin (HP:0011813)2.70701271
24Myositis (HP:0100614)2.69701893
25Pustule (HP:0200039)2.69455605
26Hyperacusis (HP:0010780)2.63257458
27Abnormality of pyrimidine metabolism (HP:0004353)2.61175106
28Abnormality of monocarboxylic acid metabolism (HP:0010996)2.60939417
29Subacute progressive viral hepatitis (HP:0006572)2.60399846
30Interstitial pulmonary disease (HP:0006530)2.56185687
31Stomatitis (HP:0010280)2.54016140
32Dysmetric saccades (HP:0000641)2.52862610
33Elevated erythrocyte sedimentation rate (HP:0003565)2.48396297
34Termporal pattern (HP:0011008)2.45770387
35Insidious onset (HP:0003587)2.45770387
36Abnormal platelet volume (HP:0011876)2.45621826
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.40626750
38Joint hemorrhage (HP:0005261)2.39146381
39Conjugated hyperbilirubinemia (HP:0002908)2.38262968
40Abnormality of the common coagulation pathway (HP:0010990)2.37394743
41Meningitis (HP:0001287)2.32347947
42Gingival bleeding (HP:0000225)2.31415912
43Petechiae (HP:0000967)2.28721579
44Urinary glycosaminoglycan excretion (HP:0003541)2.27993957
45Mucopolysacchariduria (HP:0008155)2.27993957
46Hemorrhage of the eye (HP:0011885)2.27978660
47Thin bony cortex (HP:0002753)2.27775964
48Abnormality of iron homeostasis (HP:0011031)2.26882977
49Systemic lupus erythematosus (HP:0002725)2.25129932
50Osteomyelitis (HP:0002754)2.23188632
51Abnormal gallbladder physiology (HP:0012438)2.22595007
52Cholecystitis (HP:0001082)2.22595007
53Vertebral compression fractures (HP:0002953)2.22470329
54Increased serum ferritin (HP:0003281)2.19960350
55Loss of speech (HP:0002371)2.19929557
56Increased mean platelet volume (HP:0011877)2.19853877
57Skin nodule (HP:0200036)2.17481668
58Ankyloglossia (HP:0010296)2.14667759
59Orchitis (HP:0100796)2.14542976
60Epistaxis (HP:0000421)2.13804020
61Bone pain (HP:0002653)2.13327170
62Abnormality of the Achilles tendon (HP:0005109)2.13030485
63Abnormality of transition element cation homeostasis (HP:0011030)2.12155381
64Chest pain (HP:0100749)2.11761374
65IgM deficiency (HP:0002850)2.10442116
66Spastic diplegia (HP:0001264)2.09144080
67Hypobetalipoproteinemia (HP:0003563)2.09050289
68Recurrent viral infections (HP:0004429)2.08860412
69Orthostatic hypotension (HP:0001278)2.08659922
70Micronodular cirrhosis (HP:0001413)2.07856630
71Deep venous thrombosis (HP:0002625)2.07557560
72Multiple lipomas (HP:0001012)2.07354347
73Cutaneous melanoma (HP:0012056)2.07114537
74Increased neuronal autofluorescent lipopigment (HP:0002074)2.04355785
75Abdominal distention (HP:0003270)2.04313740
76Xanthomatosis (HP:0000991)2.04225553
77Dysostosis multiplex (HP:0000943)2.04027183
78Malnutrition (HP:0004395)2.03685059
79Intrahepatic cholestasis (HP:0001406)2.03332806
80Skin ulcer (HP:0200042)2.03313275
81Agnosia (HP:0010524)2.01416841
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.01231574
83Osteolytic defects of the hand bones (HP:0009699)2.01231574
84Fat malabsorption (HP:0002630)2.00448547
85Nausea (HP:0002018)2.00176970
86Vasculitis (HP:0002633)2.00109389
87Abnormality of nucleobase metabolism (HP:0010932)2.00091060
88Multiple enchondromatosis (HP:0005701)1.98925895
89Pathologic fracture (HP:0002756)1.98025321
90Achilles tendon contracture (HP:0001771)1.97336262
91Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96561901
92Abnormality of polysaccharide metabolism (HP:0011012)1.96561901
93Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96561901
94Hyperammonemia (HP:0001987)1.95571511
95Reticulocytosis (HP:0001923)1.95536265
96Abnormality of oral frenula (HP:0000190)1.95057914
97Sparse lateral eyebrow (HP:0005338)1.94270677
98Gastrointestinal infarctions (HP:0005244)1.93568096
99Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.92566104
100Spontaneous hematomas (HP:0007420)1.92413721
101Progressive external ophthalmoplegia (HP:0000590)1.92216249
102Abnormality of T cell physiology (HP:0011840)1.91633722
103Abnormal platelet function (HP:0011869)1.91021265
104Impaired platelet aggregation (HP:0003540)1.91021265
105Hypercholesterolemia (HP:0003124)1.90878979
106Abnormality of the distal phalanges of the toes (HP:0010182)1.89570657
107Abnormality of sulfur amino acid metabolism (HP:0004339)1.88929619
108Reduced antithrombin III activity (HP:0001976)1.88587545
109Leiomyosarcoma (HP:0100243)1.88117687
110Uterine leiomyosarcoma (HP:0002891)1.88117687
111Abnormality of the prostate (HP:0008775)1.87940385
112Upper motor neuron abnormality (HP:0002127)1.87775506
113Cervical subluxation (HP:0003308)1.87320356
114Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87121174
115Thrombophlebitis (HP:0004418)1.87069624
116Esophageal varix (HP:0002040)1.86952883
117Thoracic kyphosis (HP:0002942)1.86867329
118Leukocytosis (HP:0001974)1.86613558
119Germ cell neoplasia (HP:0100728)1.85602783
120Cheilitis (HP:0100825)1.85387618
121Distal lower limb amyotrophy (HP:0008944)1.85234682
122Cholelithiasis (HP:0001081)1.84525711
123Cardiomegaly (HP:0001640)1.84180763
124Abnormal cartilage morphology (HP:0002763)1.83532589
125Back pain (HP:0003418)1.81151207
126Anorexia (HP:0002039)1.81104847
127Abnormal enzyme/coenzyme activity (HP:0012379)1.80949010
128Abnormality of the thoracic spine (HP:0100711)1.80679360
129Peritonitis (HP:0002586)1.80035496
130Hepatocellular carcinoma (HP:0001402)1.79974171
131Menorrhagia (HP:0000132)1.78529968
132Progressive muscle weakness (HP:0003323)1.78242549
133Myocardial infarction (HP:0001658)1.77834645
134Cerebral inclusion bodies (HP:0100314)1.77631007
135Pseudobulbar signs (HP:0002200)1.76677170
136Hemoptysis (HP:0002105)1.76203071
137Progressive hearing impairment (HP:0001730)1.75604361
138Hypolipoproteinemia (HP:0010981)1.75423514
139Abnormality of the gastric mucosa (HP:0004295)1.75017406
140Curly hair (HP:0002212)1.74795609
141Abnormality of alkaline phosphatase activity (HP:0004379)1.74515921
142Metaphyseal cupping (HP:0003021)1.73716391
143Coarse hair (HP:0002208)1.72830822
144Arterial thrombosis (HP:0004420)1.72158072
145Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72086784
146Hypotension (HP:0002615)1.71324421
147Abnormality of complement system (HP:0005339)1.70582863
148Hyperparathyroidism (HP:0000843)1.70109732
149Hypoglycemic coma (HP:0001325)1.69574861
150Lower limb hyperreflexia (HP:0002395)1.69554865
151Abnormality of purine metabolism (HP:0004352)1.69549037
152Granulocytopenia (HP:0001913)1.69306111
153Poikiloderma (HP:0001029)1.69066440
154Acanthocytosis (HP:0001927)1.69012080
155Prolonged bleeding time (HP:0003010)1.68311562
156Malignant gastrointestinal tract tumors (HP:0006749)1.67282880
157Gastrointestinal carcinoma (HP:0002672)1.67282880
158Tetraparesis (HP:0002273)1.65783492
159Elevated alkaline phosphatase (HP:0003155)1.65650563
160Insomnia (HP:0100785)1.65616446
161Spinal cord compression (HP:0002176)1.65252549
162Renal cell carcinoma (HP:0005584)1.65075064
163Eosinophilia (HP:0001880)1.64952366
164Hepatosplenomegaly (HP:0001433)1.64397478
165Abnormality of the anterior horn cell (HP:0006802)1.63417391
166Degeneration of anterior horn cells (HP:0002398)1.63417391
167Abnormal foot bone ossification (HP:0010675)1.62950456
168Distal lower limb muscle weakness (HP:0009053)1.62226719
169Abnormality of the gallbladder (HP:0005264)1.62158964
170Steatorrhea (HP:0002570)1.61447107
171Abnormal tarsal ossification (HP:0008369)1.60049531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.28319987
2IRAK43.16357744
3ERN12.83610255
4ICK2.71782059
5PRPF4B2.34452444
6STK102.26295075
7TESK22.15362946
8PKN22.14968688
9FGFR42.06157360
10BLK2.02905256
11MAP2K31.96438988
12EPHB11.96071341
13TESK11.92563002
14WEE11.91706029
15GRK61.86565803
16TRIB31.83165931
17CSK1.73947267
18EIF2AK31.73616983
19RIPK41.73301442
20PAK41.70472765
21LRRK21.67743461
22MAP3K141.65635219
23BTK1.64204661
24NEK21.61277799
25CAMK1D1.60384237
26SIK11.56262650
27CDC71.56204091
28KSR21.54204683
29CDK121.54101114
30TYK21.50478424
31TRPM71.49189693
32IRAK31.48473458
33PTK61.46778551
34MAP4K11.45150913
35FLT31.43645118
36MAP3K31.42445704
37ERBB41.40030236
38MAP3K21.37787061
39TEC1.37131109
40PIM11.35307268
41TBK11.34389293
42MAP3K81.33642943
43RPS6KA41.32152207
44ACVR1B1.30372866
45RIPK11.29826489
46TAOK31.26984224
47EEF2K1.26069662
48PBK1.24544564
49EPHA21.23003888
50SCYL21.20083954
51MAP3K111.16946712
52BRSK21.11196760
53PDGFRA1.10515842
54MST41.10344902
55ZAP701.10102198
56MST1R1.09856535
57TAOK21.09508315
58ALK1.08201140
59TTN1.07967396
60MAP3K131.05229813
61STK41.04887664
62RPS6KB21.04849564
63PRKG21.03930592
64MATK1.03285927
65CDK41.00660866
66JAK30.97743978
67CDK70.97391825
68PDPK10.97084622
69NEK10.94799463
70CAMK1G0.93944391
71FGFR30.93790505
72BCKDK0.92695289
73NEK90.92177230
74MAP3K10.91056036
75BMX0.89129613
76KDR0.88994901
77LATS20.88660965
78FRK0.85821906
79FES0.85171058
80MAP3K100.84894372
81PIM20.84298485
82BUB10.84066539
83TSSK60.82831406
84MET0.80126732
85MTOR0.79087808
86MAP2K20.78827576
87IKBKB0.78555408
88CDK60.78133462
89HCK0.78026563
90BMPR20.77866877
91TAOK10.73252039
92PRKD30.72860236
93EIF2AK10.72132522
94JAK20.70846952
95STK30.68783351
96ABL20.67918346
97NME20.67525165
98ATR0.66868636
99FGR0.66147456
100MAPKAPK30.65920748
101KSR10.65641067
102MAPK40.65128870
103MARK30.64897076
104MAP3K90.64510246
105PTK20.62586655
106RPS6KL10.61933290
107RPS6KC10.61933290
108RPS6KA60.61549446
109IKBKE0.61502033
110CSF1R0.61162494
111IRAK20.61098009
112MAPK110.60656408
113LIMK10.59842952
114MELK0.58782167
115AKT20.58314516
116RET0.56955751
117CLK10.56847667
118TTK0.56679129
119YES10.56500000
120ITK0.53655389
121LYN0.53350334
122AURKB0.53285796
123PLK10.52672112
124CDC42BPA0.51480641
125SYK0.49490988
126PRKCD0.48810024
127PDK10.47920032
128CHUK0.47194419
129LCK0.46264407
130KIT0.46147385
131MAPKAPK20.46036519
132MAP3K50.45181059
133STK240.44308344
134NEK60.42593945
135PDK20.42433993
136CHEK20.41891104
137PRKAA20.39878263
138BRD40.39872881
139BRAF0.38162344
140RPS6KB10.37363350
141TAF10.36826142
142MAP3K120.35671811
143ILK0.33769177
144CAMKK20.33104195
145CHEK10.31886201
146LMTK20.31463156

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.05359085
2Leishmaniasis_Homo sapiens_hsa051402.51406455
3Staphylococcus aureus infection_Homo sapiens_hsa051502.37154790
4DNA replication_Homo sapiens_hsa030302.29319281
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.26429003
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20679878
7Pentose phosphate pathway_Homo sapiens_hsa000302.17156477
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07929504
9Legionellosis_Homo sapiens_hsa051341.96965193
10One carbon pool by folate_Homo sapiens_hsa006701.88502820
11Vitamin B6 metabolism_Homo sapiens_hsa007501.75802579
12Central carbon metabolism in cancer_Homo sapiens_hsa052301.66428178
13Selenocompound metabolism_Homo sapiens_hsa004501.56496358
14Chronic myeloid leukemia_Homo sapiens_hsa052201.56110355
15Starch and sucrose metabolism_Homo sapiens_hsa005001.47517123
16Caffeine metabolism_Homo sapiens_hsa002321.37174486
17Non-small cell lung cancer_Homo sapiens_hsa052231.35469459
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.35066553
19Mismatch repair_Homo sapiens_hsa034301.31577061
20Histidine metabolism_Homo sapiens_hsa003401.30993573
21Other glycan degradation_Homo sapiens_hsa005111.30788296
22Pancreatic cancer_Homo sapiens_hsa052121.28896731
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28009780
24Folate biosynthesis_Homo sapiens_hsa007901.26066609
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.24160737
26Pertussis_Homo sapiens_hsa051331.22960573
27Complement and coagulation cascades_Homo sapiens_hsa046101.21302240
28Osteoclast differentiation_Homo sapiens_hsa043801.21203084
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.19136041
30Endometrial cancer_Homo sapiens_hsa052131.17875486
31Arginine biosynthesis_Homo sapiens_hsa002201.17765037
32Carbon metabolism_Homo sapiens_hsa012001.17723855
33Nitrogen metabolism_Homo sapiens_hsa009101.17421963
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17208450
35* Glutathione metabolism_Homo sapiens_hsa004801.14747886
36Biosynthesis of amino acids_Homo sapiens_hsa012301.12592885
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10742777
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09173768
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.07773829
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07111722
41Tuberculosis_Homo sapiens_hsa051521.07014049
42Fatty acid biosynthesis_Homo sapiens_hsa000611.06566280
43Galactose metabolism_Homo sapiens_hsa000521.05208691
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05169075
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.05001311
46Sphingolipid metabolism_Homo sapiens_hsa006001.02775732
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01753553
48Renal cell carcinoma_Homo sapiens_hsa052111.01323700
49Shigellosis_Homo sapiens_hsa051311.00668432
50Fructose and mannose metabolism_Homo sapiens_hsa000511.00015681
51Sulfur relay system_Homo sapiens_hsa041220.98125567
52Herpes simplex infection_Homo sapiens_hsa051680.97027356
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93750262
54Base excision repair_Homo sapiens_hsa034100.92562039
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92500907
56Tryptophan metabolism_Homo sapiens_hsa003800.92294055
57Apoptosis_Homo sapiens_hsa042100.92204059
58Asthma_Homo sapiens_hsa053100.92203037
59Vibrio cholerae infection_Homo sapiens_hsa051100.91967811
60Prion diseases_Homo sapiens_hsa050200.91194231
61Peroxisome_Homo sapiens_hsa041460.90641773
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90563850
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88985733
64Fatty acid degradation_Homo sapiens_hsa000710.88093139
65VEGF signaling pathway_Homo sapiens_hsa043700.86650117
66Renin-angiotensin system_Homo sapiens_hsa046140.86517695
67TNF signaling pathway_Homo sapiens_hsa046680.86354754
68Prostate cancer_Homo sapiens_hsa052150.86121594
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.84500948
70Salmonella infection_Homo sapiens_hsa051320.84012405
71Insulin signaling pathway_Homo sapiens_hsa049100.83939766
72PPAR signaling pathway_Homo sapiens_hsa033200.83228361
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.83089765
74Influenza A_Homo sapiens_hsa051640.82944789
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82578968
76mTOR signaling pathway_Homo sapiens_hsa041500.82272323
77Arginine and proline metabolism_Homo sapiens_hsa003300.82213792
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81863054
79Lysosome_Homo sapiens_hsa041420.81495596
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81282598
81Insulin resistance_Homo sapiens_hsa049310.81185950
82Phagosome_Homo sapiens_hsa041450.80809175
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79254040
84Antigen processing and presentation_Homo sapiens_hsa046120.79047586
85Cell cycle_Homo sapiens_hsa041100.77713777
86Homologous recombination_Homo sapiens_hsa034400.76761427
87Toxoplasmosis_Homo sapiens_hsa051450.76435837
88beta-Alanine metabolism_Homo sapiens_hsa004100.76256965
89Measles_Homo sapiens_hsa051620.75863443
90p53 signaling pathway_Homo sapiens_hsa041150.75239550
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75096580
92Fat digestion and absorption_Homo sapiens_hsa049750.74688174
93Sulfur metabolism_Homo sapiens_hsa009200.74352493
94Hematopoietic cell lineage_Homo sapiens_hsa046400.74144428
95Adherens junction_Homo sapiens_hsa045200.73605844
96HIF-1 signaling pathway_Homo sapiens_hsa040660.73068468
97Malaria_Homo sapiens_hsa051440.72900514
98Chemical carcinogenesis_Homo sapiens_hsa052040.72811078
99Systemic lupus erythematosus_Homo sapiens_hsa053220.72127949
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70776793
101Vitamin digestion and absorption_Homo sapiens_hsa049770.70491876
102Acute myeloid leukemia_Homo sapiens_hsa052210.69589395
103RNA transport_Homo sapiens_hsa030130.69526242
104Pyruvate metabolism_Homo sapiens_hsa006200.69246969
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.68470632
106N-Glycan biosynthesis_Homo sapiens_hsa005100.67428561
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.67048377
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65458818
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65112637
110Hepatitis B_Homo sapiens_hsa051610.64530704
111Proteoglycans in cancer_Homo sapiens_hsa052050.64233719
112AMPK signaling pathway_Homo sapiens_hsa041520.63946414
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63773490
114Small cell lung cancer_Homo sapiens_hsa052220.63682573
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63370408
116Prolactin signaling pathway_Homo sapiens_hsa049170.63025913
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.61970310
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60581250
119Bladder cancer_Homo sapiens_hsa052190.60418828
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59145265
121Fatty acid metabolism_Homo sapiens_hsa012120.59141063
122Mineral absorption_Homo sapiens_hsa049780.59035442
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58348638
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58198071
125Viral carcinogenesis_Homo sapiens_hsa052030.57997452
126ABC transporters_Homo sapiens_hsa020100.57508739
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57487864
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56932806
129Bile secretion_Homo sapiens_hsa049760.56865038
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56656559
131Pyrimidine metabolism_Homo sapiens_hsa002400.56641889
132B cell receptor signaling pathway_Homo sapiens_hsa046620.55013640
133ErbB signaling pathway_Homo sapiens_hsa040120.54974775
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54018858
135Steroid biosynthesis_Homo sapiens_hsa001000.53630696
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53181713
137Phenylalanine metabolism_Homo sapiens_hsa003600.51710193
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51541147
139Thyroid cancer_Homo sapiens_hsa052160.51431414
140Proteasome_Homo sapiens_hsa030500.51191370
141Hepatitis C_Homo sapiens_hsa051600.50929323
142MicroRNAs in cancer_Homo sapiens_hsa052060.49687697
143Glioma_Homo sapiens_hsa052140.48701080
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.47599324
145Inositol phosphate metabolism_Homo sapiens_hsa005620.46456917

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