GRPEL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)6.90722291
2daunorubicin metabolic process (GO:0044597)6.90722291
3polyketide metabolic process (GO:0030638)6.90722291
4coenzyme catabolic process (GO:0009109)5.64819256
5nuclear pore complex assembly (GO:0051292)4.96250740
6aminoglycoside antibiotic metabolic process (GO:0030647)4.87087950
7cellular modified amino acid catabolic process (GO:0042219)4.79336494
8somite rostral/caudal axis specification (GO:0032525)4.75980548
9sulfur amino acid catabolic process (GO:0000098)4.62567395
10nuclear pore organization (GO:0006999)4.59123049
11L-phenylalanine metabolic process (GO:0006558)4.58136473
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.58136473
13L-phenylalanine catabolic process (GO:0006559)4.50270757
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.50270757
15hormone catabolic process (GO:0042447)4.44822600
16epoxygenase P450 pathway (GO:0019373)4.42640289
17negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.35666982
18somatic diversification of immune receptors via somatic mutation (GO:0002566)4.31128678
19somatic hypermutation of immunoglobulin genes (GO:0016446)4.31128678
20negative regulation of epidermis development (GO:0045683)4.29322538
21regulation of nuclear cell cycle DNA replication (GO:0033262)4.24728769
22mitotic sister chromatid cohesion (GO:0007064)4.24699257
23chromatin remodeling at centromere (GO:0031055)4.21371832
24CENP-A containing nucleosome assembly (GO:0034080)4.18477732
25protein localization to chromosome, centromeric region (GO:0071459)4.18308930
26negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.16935495
27maintenance of protein location in nucleus (GO:0051457)4.16312737
28aromatic amino acid family catabolic process (GO:0009074)4.15463741
29positive regulation of mitotic sister chromatid separation (GO:1901970)4.11379290
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.11379290
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.11379290
32regulation of mammary gland epithelial cell proliferation (GO:0033599)4.10478933
33rRNA transcription (GO:0009303)4.09449103
34positive regulation of chromosome segregation (GO:0051984)4.09115010
35sister chromatid segregation (GO:0000819)4.08462095
36protein localization to kinetochore (GO:0034501)4.07281884
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.05168319
38regulation of meiosis I (GO:0060631)3.99214129
39mitotic metaphase plate congression (GO:0007080)3.98685887
40regulation of telomere maintenance via telomerase (GO:0032210)3.93408220
41cofactor catabolic process (GO:0051187)3.92779707
42regulation of sister chromatid cohesion (GO:0007063)3.89199930
43regulation of translation in response to stress (GO:0043555)3.85608058
44indole-containing compound catabolic process (GO:0042436)3.82403205
45indolalkylamine catabolic process (GO:0046218)3.82403205
46tryptophan catabolic process (GO:0006569)3.82403205
47glycine metabolic process (GO:0006544)3.81708741
48cytidine metabolic process (GO:0046087)3.80680539
49cytidine catabolic process (GO:0006216)3.80680539
50cytidine deamination (GO:0009972)3.80680539
51serine family amino acid catabolic process (GO:0009071)3.76994850
52drug metabolic process (GO:0017144)3.75622569
53DNA strand elongation involved in DNA replication (GO:0006271)3.69945954
54regulation of response to osmotic stress (GO:0047484)3.68872663
55metaphase plate congression (GO:0051310)3.67862421
56negative regulation of cell cycle G2/M phase transition (GO:1902750)3.67737567
57ribosome assembly (GO:0042255)3.65561090
58rRNA modification (GO:0000154)3.64428089
59kynurenine metabolic process (GO:0070189)3.64268218
60quinone metabolic process (GO:1901661)3.62289260
61rRNA methylation (GO:0031167)3.61902795
62heme transport (GO:0015886)3.61273594
63regulation of centriole replication (GO:0046599)3.60992493
64histone exchange (GO:0043486)3.58491434
65DNA strand elongation (GO:0022616)3.58241413
66pore complex assembly (GO:0046931)3.57211517
67tryptophan metabolic process (GO:0006568)3.56250881
68non-recombinational repair (GO:0000726)3.56012074
69double-strand break repair via nonhomologous end joining (GO:0006303)3.56012074
70triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.55775517
71muscle organ morphogenesis (GO:0048644)3.55245787
72glyoxylate metabolic process (GO:0046487)3.53652479
73primary alcohol catabolic process (GO:0034310)3.53383288
74regulation of DNA endoreduplication (GO:0032875)3.53285701
75negative regulation of DNA-dependent DNA replication (GO:2000104)3.52854721
76negative regulation of epidermal cell differentiation (GO:0045605)3.51532569
77telomere maintenance via recombination (GO:0000722)3.48480188
78regulation of chromosome segregation (GO:0051983)3.48003403
79proteasome assembly (GO:0043248)3.44890541
80prenylation (GO:0097354)3.43767303
81protein prenylation (GO:0018342)3.43767303
82attachment of spindle microtubules to kinetochore (GO:0008608)3.43045558
83cullin deneddylation (GO:0010388)3.41692099
84mitotic chromosome condensation (GO:0007076)3.40713600
85serine family amino acid biosynthetic process (GO:0009070)3.40672156
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.40158464
87regulation of mitotic metaphase/anaphase transition (GO:0030071)3.40158464
88mitotic recombination (GO:0006312)3.39060103
89L-ascorbic acid metabolic process (GO:0019852)3.37515634
90spindle checkpoint (GO:0031577)3.36597498
91telomere maintenance via semi-conservative replication (GO:0032201)3.36529398
92cofactor transport (GO:0051181)3.36267948
93heterochromatin organization (GO:0070828)3.36168230
94DNA replication-independent nucleosome assembly (GO:0006336)3.35566103
95DNA replication-independent nucleosome organization (GO:0034724)3.35566103
96negative regulation of telomerase activity (GO:0051974)3.35140592
97mitotic nuclear envelope disassembly (GO:0007077)3.34974307
98regulation of MHC class I biosynthetic process (GO:0045343)3.34483906
99regulation of mitotic sister chromatid separation (GO:0010965)3.33840799
100regulation of mitotic sister chromatid segregation (GO:0033047)3.33840799
101regulation of sister chromatid segregation (GO:0033045)3.33840799
102homocysteine metabolic process (GO:0050667)3.33543655
103mitochondrial RNA metabolic process (GO:0000959)3.28215129
104nucleoside transmembrane transport (GO:1901642)3.28105292
105negative regulation of chromosome segregation (GO:0051985)3.28047138
106serine family amino acid metabolic process (GO:0009069)3.27934032
107cysteine metabolic process (GO:0006534)3.27753809
108pteridine-containing compound biosynthetic process (GO:0042559)3.27697987
109high-density lipoprotein particle remodeling (GO:0034375)3.27232545
110urea metabolic process (GO:0019627)3.24429731
111urea cycle (GO:0000050)3.24429731
112notochord development (GO:0030903)3.23617675
113DNA unwinding involved in DNA replication (GO:0006268)3.23457265
114protein K6-linked ubiquitination (GO:0085020)3.23323959
115mitotic spindle checkpoint (GO:0071174)3.22884246
116DNA replication-dependent nucleosome assembly (GO:0006335)3.21864568
117DNA replication-dependent nucleosome organization (GO:0034723)3.21864568
118negative regulation of mitotic sister chromatid separation (GO:2000816)3.21805138
119negative regulation of sister chromatid segregation (GO:0033046)3.21805138
120negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21805138
121negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.21805138
122negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21805138
123protein complex localization (GO:0031503)3.21312108
124cellular protein complex localization (GO:0034629)3.19860860
125regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17106299
126regulation of mitotic spindle checkpoint (GO:1903504)3.17106299
127DNA replication initiation (GO:0006270)3.16743250
128nuclear envelope disassembly (GO:0051081)3.16659187
129membrane disassembly (GO:0030397)3.16659187
130positive regulation of DNA-dependent DNA replication (GO:2000105)3.15935785
131regulation of centrosome cycle (GO:0046605)3.15164205
132replication fork processing (GO:0031297)3.13584068
133DNA replication checkpoint (GO:0000076)3.13492016
134histone H4-K8 acetylation (GO:0043982)3.13091410
135histone H4-K5 acetylation (GO:0043981)3.13091410
136bile acid biosynthetic process (GO:0006699)3.12187443
137DNA double-strand break processing (GO:0000729)3.10404018
138formation of translation preinitiation complex (GO:0001731)3.10218888
139establishment of integrated proviral latency (GO:0075713)3.10125685
140aromatic amino acid family metabolic process (GO:0009072)3.10050195
141regulation of spindle organization (GO:0090224)3.10017152
142regulation of apoptotic process involved in morphogenesis (GO:1902337)3.09853420
143cellular amino acid catabolic process (GO:0009063)3.08877939
144mitotic sister chromatid segregation (GO:0000070)3.06297231
145negative regulation of meiosis (GO:0045835)3.06157478
146ribosome biogenesis (GO:0042254)3.05532355
147alpha-amino acid catabolic process (GO:1901606)3.05070679
148response to dietary excess (GO:0002021)3.04563699
149negative regulation of fibrinolysis (GO:0051918)3.04272566
150omega-hydroxylase P450 pathway (GO:0097267)3.03872556
151biotin metabolic process (GO:0006768)3.03832848
152histone H4-K12 acetylation (GO:0043983)3.03058501
153nitrogen cycle metabolic process (GO:0071941)3.02906567
154imidazole-containing compound metabolic process (GO:0052803)3.02707397
155flavonoid metabolic process (GO:0009812)3.01715327
156protein deneddylation (GO:0000338)3.01326231
157telomere maintenance via telomere lengthening (GO:0010833)3.00960585
158resolution of meiotic recombination intermediates (GO:0000712)2.99920075
159primitive streak formation (GO:0090009)2.99510622
160pseudouridine synthesis (GO:0001522)2.98437198
161negative regulation of telomere maintenance (GO:0032205)2.98273074
162regulation of cilium movement (GO:0003352)2.97681160
163protein localization to chromosome (GO:0034502)2.97231294
164meiotic chromosome segregation (GO:0045132)2.95819856
165amino acid activation (GO:0043038)2.94740706
166tRNA aminoacylation (GO:0043039)2.94740706
167regulation of lipoprotein particle clearance (GO:0010984)2.94640290
168establishment of chromosome localization (GO:0051303)2.94587472
169L-serine metabolic process (GO:0006563)2.94076211
170kinetochore organization (GO:0051383)2.93748902
171folic acid metabolic process (GO:0046655)2.93523399
172mitotic spindle assembly checkpoint (GO:0007094)2.93459894
173ribosomal small subunit biogenesis (GO:0042274)2.93355678
174spindle assembly checkpoint (GO:0071173)2.92707926
175synapsis (GO:0007129)2.92692220
176intestinal epithelial cell development (GO:0060576)2.92146884
177tRNA aminoacylation for protein translation (GO:0006418)2.91641249
178amino-acid betaine metabolic process (GO:0006577)2.91324820
179regulation of helicase activity (GO:0051095)2.89866538
180mitotic G2/M transition checkpoint (GO:0044818)2.86961737
181negative regulation of DNA recombination (GO:0045910)2.86283804
182pyrimidine nucleoside catabolic process (GO:0046135)2.85939723
183chromosome segregation (GO:0007059)2.83060166
184regulation of fibrinolysis (GO:0051917)2.82512106
185branched-chain amino acid catabolic process (GO:0009083)2.81162708
186regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81073411
187negative regulation of cholesterol transport (GO:0032375)2.80522554
188IMP biosynthetic process (GO:0006188)2.80373598
189maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80202539
190DNA damage response, detection of DNA damage (GO:0042769)2.77936428
191regulation of centrosome duplication (GO:0010824)2.75638119
192telomere maintenance via telomerase (GO:0007004)2.72666208
193sister chromatid cohesion (GO:0007062)2.71839461
194telomere maintenance (GO:0000723)2.71096507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.74578502
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.74578502
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.74578502
4E2F7_22180533_ChIP-Seq_HELA_Human4.65007041
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.15363698
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.99197633
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.81582278
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.47203792
9* RXR_22158963_ChIP-Seq_LIVER_Mouse2.96202653
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.84120282
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.78320182
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.69268254
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.68042409
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.61041839
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59076722
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.49502956
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46120834
18* ELK1_19687146_ChIP-ChIP_HELA_Human2.42202649
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38929077
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.23199596
21SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.20297673
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.19531585
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12171732
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.10321939
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09893015
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.08631289
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05871536
28LXR_22158963_ChIP-Seq_LIVER_Mouse2.05161386
29TCF3_18692474_ChIP-Seq_MEFs_Mouse2.04684841
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.03327517
31STAT3_1855785_ChIP-Seq_MESCs_Mouse2.01274763
32IRF1_19129219_ChIP-ChIP_H3396_Human2.00804306
33TCF3_18692474_ChIP-Seq_MESCs_Mouse1.99702360
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97923802
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97486796
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97273656
37* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95372092
38EWS_26573619_Chip-Seq_HEK293_Human1.93906399
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92126751
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91891511
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88112168
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87695744
43* EST1_17652178_ChIP-ChIP_JURKAT_Human1.84883676
44FUS_26573619_Chip-Seq_HEK293_Human1.84621975
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.84300120
46NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.82905223
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82602272
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81204397
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71516853
50* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68731793
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66221825
52VDR_22108803_ChIP-Seq_LS180_Human1.65954811
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62423841
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.61752124
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59447529
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56013277
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53463991
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52629803
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50878308
60ZNF274_21170338_ChIP-Seq_K562_Hela1.49979289
61* GABP_17652178_ChIP-ChIP_JURKAT_Human1.48824000
62* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46747790
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46370566
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.43784970
65IGF1R_20145208_ChIP-Seq_DFB_Human1.40892080
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39325980
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38280723
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37928010
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36182262
70* MYC_18940864_ChIP-ChIP_HL60_Human1.33539515
71OCT4_18692474_ChIP-Seq_MEFs_Mouse1.32885132
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31188309
73NANOG_18692474_ChIP-Seq_MEFs_Mouse1.30566402
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29649723
75AR_21909140_ChIP-Seq_LNCAP_Human1.26974058
76TAF15_26573619_Chip-Seq_HEK293_Human1.26582224
77POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26381989
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.26129445
79FOXP3_21729870_ChIP-Seq_TREG_Human1.25236492
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23511647
81NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22956642
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22785337
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21771626
84* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21718689
85SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20520096
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19915840
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19523286
88* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18507241
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16902934
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.16581426
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16303807
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.15561722
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14900945
94NANOG_18692474_ChIP-Seq_MESCs_Mouse1.13819436
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12826947
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11456710
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.10460606
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09852970
99KDM5A_27292631_Chip-Seq_BREAST_Human1.09511974
100P300_19829295_ChIP-Seq_ESCs_Human1.08611774
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08103373
102FLI1_27457419_Chip-Seq_LIVER_Mouse1.06247921
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05692948
104* XRN2_22483619_ChIP-Seq_HELA_Human1.05390975
105SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04018485
106NANOG_16518401_ChIP-PET_MESCs_Mouse1.02598643
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01011864
108VDR_23849224_ChIP-Seq_CD4+_Human0.99743733
109* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97951745
110E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97369545
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.96401227
112* GABP_19822575_ChIP-Seq_HepG2_Human0.94694253
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94496451
114ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94049529
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93555484
116TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93025004
117* NANOG_16153702_ChIP-ChIP_HESCs_Human0.92835328
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92290751
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91457925
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90536969
121* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90217406
122DCP1A_22483619_ChIP-Seq_HELA_Human0.88764310
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88474063
124FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87836130
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.86566406
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86533764
127ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86008256
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.85828775
129CHD1_26751641_Chip-Seq_LNCaP_Human0.85754033
130* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85353734
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84783544
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84263127
133HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83241080
134TP63_17297297_ChIP-ChIP_HaCaT_Human0.82689816
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81890931
136* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81039770
137TTF2_22483619_ChIP-Seq_HELA_Human0.80990360
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80721810
139TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78137722
140HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78127915
141CIITA_25753668_ChIP-Seq_RAJI_Human0.77173619
142WT1_19549856_ChIP-ChIP_CCG9911_Human0.76463474
143FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.76243799
144PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.76026223
145POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.75867214
146* TFEB_21752829_ChIP-Seq_HELA_Human0.74901800
147SOX9_26525672_Chip-Seq_HEART_Mouse0.74670060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.89342319
2MP0002139_abnormal_hepatobiliary_system4.86519275
3MP0005360_urolithiasis4.27864650
4MP0005085_abnormal_gallbladder_physiolo4.08237986
5MP0002254_reproductive_system_inflammat3.93431899
6MP0005365_abnormal_bile_salt3.70192826
7MP0003806_abnormal_nucleotide_metabolis3.32388818
8MP0008875_abnormal_xenobiotic_pharmacok3.31598867
9MP0004264_abnormal_extraembryonic_tissu3.28498597
10MP0003890_abnormal_embryonic-extraembry2.81538061
11MP0008877_abnormal_DNA_methylation2.52130101
12MP0008932_abnormal_embryonic_tissue2.44911246
13MP0006035_abnormal_mitochondrial_morpho2.42797824
14MP0004957_abnormal_blastocyst_morpholog2.41907701
15MP0003941_abnormal_skin_development2.41672037
16MP0006292_abnormal_olfactory_placode2.41197252
17MP0003252_abnormal_bile_duct2.33500068
18MP0005075_abnormal_melanosome_morpholog2.33247873
19MP0002009_preneoplasia2.32975303
20MP0005394_taste/olfaction_phenotype2.07625320
21MP0005499_abnormal_olfactory_system2.07625320
22MP0003705_abnormal_hypodermis_morpholog2.02379764
23MP0005257_abnormal_intraocular_pressure2.01313377
24MP0000566_synostosis1.99238443
25MP0005083_abnormal_biliary_tract1.86342460
26MP0003937_abnormal_limbs/digits/tail_de1.85519927
27MP0008007_abnormal_cellular_replicative1.80408984
28MP0001188_hyperpigmentation1.78730031
29MP0008057_abnormal_DNA_replication1.72048815
30MP0010329_abnormal_lipoprotein_level1.70647451
31MP0003567_abnormal_fetal_cardiomyocyte1.70543162
32MP0005332_abnormal_amino_acid1.67239518
33MP0003195_calcinosis1.66158900
34MP0002332_abnormal_exercise_endurance1.65294693
35MP0002132_abnormal_respiratory_system1.63565933
36MP0010352_gastrointestinal_tract_polyps1.57444387
37MP0009672_abnormal_birth_weight1.54318107
38MP0005319_abnormal_enzyme/_coenzyme1.50493958
39MP0001529_abnormal_vocalization1.49721017
40MP0000609_abnormal_liver_physiology1.49712671
41MP0004019_abnormal_vitamin_homeostasis1.46381363
42MP0003186_abnormal_redox_activity1.41712711
43MP0001666_abnormal_nutrient_absorption1.40947241
44MP0004381_abnormal_hair_follicle1.40906144
45MP0002084_abnormal_developmental_patter1.40239132
46MP0002277_abnormal_respiratory_mucosa1.38767400
47MP0001697_abnormal_embryo_size1.36375252
48MP0002234_abnormal_pharynx_morphology1.33958572
49MP0002210_abnormal_sex_determination1.33174919
50MP0010307_abnormal_tumor_latency1.30996939
51MP0005266_abnormal_metabolism1.25290970
52MP0009840_abnormal_foam_cell1.24254974
53MP0004233_abnormal_muscle_weight1.23651358
54MP0005380_embryogenesis_phenotype1.23395331
55MP0001672_abnormal_embryogenesis/_devel1.23395331
56MP0002796_impaired_skin_barrier1.22737713
57MP0006036_abnormal_mitochondrial_physio1.22266818
58MP0002697_abnormal_eye_size1.21663895
59MP0001929_abnormal_gametogenesis1.18132972
60MP0004782_abnormal_surfactant_physiolog1.17072565
61MP0002751_abnormal_autonomic_nervous1.16329926
62MP0002102_abnormal_ear_morphology1.16211623
63MP0002080_prenatal_lethality1.15810486
64MP0002088_abnormal_embryonic_growth/wei1.15727365
65MP0002160_abnormal_reproductive_system1.15170732
66MP0009703_decreased_birth_body1.14495112
67MP0003984_embryonic_growth_retardation1.13194903
68MP0001145_abnormal_male_reproductive1.11960247
69MP0002127_abnormal_cardiovascular_syste1.10414895
70MP0002138_abnormal_hepatobiliary_system1.10348640
71MP0001919_abnormal_reproductive_system1.09070886
72MP0000762_abnormal_tongue_morphology1.08442855
73MP0003935_abnormal_craniofacial_develop1.07871885
74MP0003077_abnormal_cell_cycle1.06446837
75MP0003755_abnormal_palate_morphology1.06430356
76MP0010030_abnormal_orbit_morphology1.03841002
77MP0002092_abnormal_eye_morphology1.03836299
78MP0000537_abnormal_urethra_morphology1.03641525
79MP0008789_abnormal_olfactory_epithelium1.03529640
80MP0010094_abnormal_chromosome_stability1.03174401
81MP0001293_anophthalmia1.02788659
82MP0000678_abnormal_parathyroid_gland1.02538952
83MP0003121_genomic_imprinting1.02346282
84MP0000653_abnormal_sex_gland1.01040794
85MP0004043_abnormal_pH_regulation1.00616803
86MP0005623_abnormal_meninges_morphology1.00593920
87MP0003938_abnormal_ear_development1.00404887
88MP0004858_abnormal_nervous_system1.00397269
89MP0003123_paternal_imprinting0.99548523
90MP0001346_abnormal_lacrimal_gland0.94237751
91MP0005248_abnormal_Harderian_gland0.93794667
92MP0003221_abnormal_cardiomyocyte_apopto0.93448944
93MP0003693_abnormal_embryo_hatching0.92486114
94MP0003861_abnormal_nervous_system0.92314507
95MP0000598_abnormal_liver_morphology0.91253460
96MP0003122_maternal_imprinting0.90043045
97MP0000467_abnormal_esophagus_morphology0.89136053
98MP0001764_abnormal_homeostasis0.88742939
99MP0010678_abnormal_skin_adnexa0.88635563
100MP0008058_abnormal_DNA_repair0.88565456
101MP0005389_reproductive_system_phenotype0.88357543
102MP0002098_abnormal_vibrissa_morphology0.88132720
103MP0002111_abnormal_tail_morphology0.87678207
104MP0003718_maternal_effect0.87569892
105MP0000350_abnormal_cell_proliferation0.87314280
106MP0005187_abnormal_penis_morphology0.86907757
107MP0006082_CNS_inflammation0.86727620
108MP0000427_abnormal_hair_cycle0.86491200
109MP0002086_abnormal_extraembryonic_tissu0.85074821
110MP0005376_homeostasis/metabolism_phenot0.84424505
111MP0003786_premature_aging0.84328911
112MP0000432_abnormal_head_morphology0.84272950
113MP0003880_abnormal_central_pattern0.84066865
114MP0001849_ear_inflammation0.83709646
115MP0003698_abnormal_male_reproductive0.83653137
116MP0002396_abnormal_hematopoietic_system0.83124141
117MP0001177_atelectasis0.82931476
118MP0005367_renal/urinary_system_phenotyp0.82121536
119MP0000516_abnormal_urinary_system0.82121536
120MP0003111_abnormal_nucleus_morphology0.81997860
121MP0000049_abnormal_middle_ear0.81454889
122MP0003868_abnormal_feces_composition0.80801361
123MP0003183_abnormal_peptide_metabolism0.80634214
124MP0002118_abnormal_lipid_homeostasis0.80128076
125MP0005501_abnormal_skin_physiology0.78894522
126MP0002970_abnormal_white_adipose0.78786749
127MP0003119_abnormal_digestive_system0.78564575
128MP0000428_abnormal_craniofacial_morphol0.78385697
129MP0009697_abnormal_copulation0.77986644
130MP0002653_abnormal_ependyma_morphology0.77587009
131MP0001730_embryonic_growth_arrest0.76843345
132MP0000631_abnormal_neuroendocrine_gland0.76824894
133MP0002932_abnormal_joint_morphology0.76200100
134MP0003646_muscle_fatigue0.75360665
135MP0009643_abnormal_urine_homeostasis0.74775758
136MP0000383_abnormal_hair_follicle0.74217445
137MP0003315_abnormal_perineum_morphology0.71311668
138MP0000377_abnormal_hair_follicle0.71073476
139MP0002161_abnormal_fertility/fecundity0.70214961
140MP0005584_abnormal_enzyme/coenzyme_acti0.69269012
141MP0003115_abnormal_respiratory_system0.68955290
142MP0001119_abnormal_female_reproductive0.68867519
143MP0005391_vision/eye_phenotype0.68493569
144MP0002081_perinatal_lethality0.68034564
145MP0002233_abnormal_nose_morphology0.68022277
146MP0001299_abnormal_eye_distance/0.67642836
147MP0002877_abnormal_melanocyte_morpholog0.65949553
148MP0003936_abnormal_reproductive_system0.65500458
149MP0000579_abnormal_nail_morphology0.65381619
150MP0003385_abnormal_body_wall0.65264537
151MP0000358_abnormal_cell_content/0.64677963
152MP0002085_abnormal_embryonic_tissue0.64220902
153MP0000490_abnormal_crypts_of0.62397520
154MP0002184_abnormal_innervation0.62305914
155MP0004197_abnormal_fetal_growth/weight/0.61772186
156MP0000647_abnormal_sebaceous_gland0.61099884
157MP0001286_abnormal_eye_development0.59836951
158MP0008961_abnormal_basal_metabolism0.57505895
159MP0010234_abnormal_vibrissa_follicle0.57151073
160MP0000313_abnormal_cell_death0.57024036
161MP0009765_abnormal_xenobiotic_induced0.56658325
162MP0005647_abnormal_sex_gland0.56447607

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.67891419
2Bilateral microphthalmos (HP:0007633)5.64055518
3Multiple enchondromatosis (HP:0005701)4.85080948
4Hepatoblastoma (HP:0002884)4.73903755
5Intrahepatic cholestasis (HP:0001406)4.27116293
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.06991748
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.80285782
8Abnormality of the lower motor neuron (HP:0002366)3.76940034
9Ependymoma (HP:0002888)3.50367355
10Hyperglycinuria (HP:0003108)3.49978861
11Hypobetalipoproteinemia (HP:0003563)3.48843979
12Abnormal cartilage morphology (HP:0002763)3.48808985
13Abnormality of the intrinsic pathway (HP:0010989)3.31406621
14Birth length less than 3rd percentile (HP:0003561)3.30008327
15Ragged-red muscle fibers (HP:0003200)3.29615632
16Increased serum pyruvate (HP:0003542)3.27223251
17Abnormality of glycolysis (HP:0004366)3.27223251
18Rhabdomyosarcoma (HP:0002859)3.26648863
19Hyperinsulinemic hypoglycemia (HP:0000825)3.25327619
20Gout (HP:0001997)3.16762827
21Xanthomatosis (HP:0000991)3.14185796
22Abnormality of the labia minora (HP:0012880)3.10920771
23Malnutrition (HP:0004395)3.07190470
24Neoplasm of striated muscle (HP:0009728)3.04419832
25Rib fusion (HP:0000902)2.99559313
26Reduced antithrombin III activity (HP:0001976)2.97363169
27Abnormality of glycine metabolism (HP:0010895)2.93292352
28Abnormality of serine family amino acid metabolism (HP:0010894)2.93292352
29Hypochromic anemia (HP:0001931)2.89949636
30Volvulus (HP:0002580)2.89099567
31Abnormality of chromosome stability (HP:0003220)2.86407130
32Deep venous thrombosis (HP:0002625)2.86323112
33Duplicated collecting system (HP:0000081)2.85969151
343-Methylglutaconic aciduria (HP:0003535)2.83819108
35Prolonged partial thromboplastin time (HP:0003645)2.80632726
36Hyperammonemia (HP:0001987)2.79475083
37Skin nodule (HP:0200036)2.77820557
38Colon cancer (HP:0003003)2.75831792
39Testicular atrophy (HP:0000029)2.72934804
40Cortical dysplasia (HP:0002539)2.71344594
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69213471
42Glioma (HP:0009733)2.68728068
43Hyperglycinemia (HP:0002154)2.67847300
44Abnormality of the preputium (HP:0100587)2.65211550
45Abnormality of pyrimidine metabolism (HP:0004353)2.64164423
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.59758667
47Meckel diverticulum (HP:0002245)2.58662174
48Impulsivity (HP:0100710)2.55176093
49Aplasia/Hypoplasia of the fovea (HP:0008060)2.53480374
50Hypoplasia of the fovea (HP:0007750)2.53480374
51Abnormality of the renal collecting system (HP:0004742)2.52951199
52Biliary tract neoplasm (HP:0100574)2.52406941
53Hypolipoproteinemia (HP:0010981)2.49806989
54Abnormality of methionine metabolism (HP:0010901)2.43892451
55Tetraplegia (HP:0002445)2.43377213
56Abnormality of the ileum (HP:0001549)2.43022020
57Trismus (HP:0000211)2.42251744
58Medulloblastoma (HP:0002885)2.42183556
59Abnormality of the salivary glands (HP:0010286)2.41574014
60Microvesicular hepatic steatosis (HP:0001414)2.40802183
61Chromsome breakage (HP:0040012)2.40186030
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39242022
63Nephroblastoma (Wilms tumor) (HP:0002667)2.39109725
64Abnormality of sulfur amino acid metabolism (HP:0004339)2.37081491
65Duodenal stenosis (HP:0100867)2.33569625
66Small intestinal stenosis (HP:0012848)2.33569625
67Long foot (HP:0001833)2.31469169
68Rectal fistula (HP:0100590)2.30050559
69Rectovaginal fistula (HP:0000143)2.30050559
70Abnormal hemoglobin (HP:0011902)2.29837362
71Hyperventilation (HP:0002883)2.26612826
72Vaginal fistula (HP:0004320)2.25913698
73Embryonal renal neoplasm (HP:0011794)2.24196801
74Partial duplication of thumb phalanx (HP:0009944)2.23274155
75Abnormal lung lobation (HP:0002101)2.22250547
76Upper motor neuron abnormality (HP:0002127)2.21087482
77Abnormality of alanine metabolism (HP:0010916)2.19153572
78Hyperalaninemia (HP:0003348)2.19153572
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19153572
80Abnormality of glutamine family amino acid metabolism (HP:0010902)2.18079778
81Sensory axonal neuropathy (HP:0003390)2.17992719
82Anomalous pulmonary venous return (HP:0010772)2.17978629
83Fused cervical vertebrae (HP:0002949)2.17740887
84Progressive external ophthalmoplegia (HP:0000590)2.16843887
85Septate vagina (HP:0001153)2.15111668
86Pendular nystagmus (HP:0012043)2.14692625
87Fat malabsorption (HP:0002630)2.14249104
88Abnormality of the astrocytes (HP:0100707)2.12273776
89Astrocytoma (HP:0009592)2.12273776
90Ectopic kidney (HP:0000086)2.11301231
91Absent radius (HP:0003974)2.11020626
92Metabolic acidosis (HP:0001942)2.10720779
93Ketosis (HP:0001946)2.09915902
94Hypoalphalipoproteinemia (HP:0003233)2.08366030
95Abnormality of the pons (HP:0007361)2.07455070
96Abnormality of nucleobase metabolism (HP:0010932)2.07429238
97Absent eyebrow (HP:0002223)2.06055143
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.05986379
99Pancreatic islet-cell hyperplasia (HP:0004510)2.04857020
100Abnormality of the duodenum (HP:0002246)2.04781847
101Horizontal nystagmus (HP:0000666)2.02529924
102Microretrognathia (HP:0000308)2.02225625
103Delayed CNS myelination (HP:0002188)2.01980804
104Abnormality of endocrine pancreas physiology (HP:0012093)2.01624329
105Abnormality of the pancreatic islet cells (HP:0006476)2.01624329
106Abnormality of small intestinal villus morphology (HP:0011472)2.00127211
107Villous atrophy (HP:0011473)2.00127211
108Progressive muscle weakness (HP:0003323)2.00063386
109Amyotrophic lateral sclerosis (HP:0007354)1.99647820
110Tongue fasciculations (HP:0001308)1.98833759
111Curly hair (HP:0002212)1.98652481
112Sloping forehead (HP:0000340)1.98394915
113Premature ovarian failure (HP:0008209)1.98335233
114Abnormal biliary tract physiology (HP:0012439)1.97998677
115Bile duct proliferation (HP:0001408)1.97998677
116Horseshoe kidney (HP:0000085)1.97424103
117Agnosia (HP:0010524)1.97342621
118Hypoplasia of the pons (HP:0012110)1.96806159
119Hyperlipoproteinemia (HP:0010980)1.96473757
120Sparse eyelashes (HP:0000653)1.96175146
121Aplasia involving forearm bones (HP:0009822)1.96106349
122Absent forearm bone (HP:0003953)1.96106349
123Lethargy (HP:0001254)1.94938039
124Bifid tongue (HP:0010297)1.94585550
125Myelodysplasia (HP:0002863)1.94474771
126Secondary amenorrhea (HP:0000869)1.94444345
127Increased purine levels (HP:0004368)1.93716383
128Hyperuricemia (HP:0002149)1.93716383
129Neoplasm of the colon (HP:0100273)1.93652083
130Combined immunodeficiency (HP:0005387)1.91200248
131Abnormal biliary tract morphology (HP:0012440)1.91099289
132Shawl scrotum (HP:0000049)1.89999728
133Intestinal fistula (HP:0100819)1.89973231
134Partial duplication of the phalanx of hand (HP:0009999)1.87908508
135Clubbing of toes (HP:0100760)1.86114718
136Abnormality of the pulmonary veins (HP:0011718)1.85872957
137Joint hemorrhage (HP:0005261)1.85816033
138Aplasia/Hypoplasia of the macula (HP:0008059)1.85114355
139Abnormality of serum amino acid levels (HP:0003112)1.85093871
140Preauricular skin tag (HP:0000384)1.81274864
141Ureteral duplication (HP:0000073)1.80267377
142Aplasia/Hypoplasia of the sternum (HP:0006714)1.79918148
143Pseudobulbar signs (HP:0002200)1.79746679
144Neoplasm of the small intestine (HP:0100833)1.75962625
145Increased nuchal translucency (HP:0010880)1.75703165
146Cafe-au-lait spot (HP:0000957)1.73711431
147Scrotal hypoplasia (HP:0000046)1.73367786
148Facial cleft (HP:0002006)1.72346656
149Papillary thyroid carcinoma (HP:0002895)1.70914540
150Broad-based gait (HP:0002136)1.70670227
151Stenosis of the external auditory canal (HP:0000402)1.68203366
152Triphalangeal thumb (HP:0001199)1.68075644
153Freckling (HP:0001480)1.66559773
154Short middle phalanx of the 5th finger (HP:0004220)1.65902414
155Median cleft lip (HP:0000161)1.65364562
156Limb hypertonia (HP:0002509)1.62033517
157Abnormality of the carotid arteries (HP:0005344)1.61599238
158Carpal bone hypoplasia (HP:0001498)1.61302740
159Cystic hygroma (HP:0000476)1.59670421
160High anterior hairline (HP:0009890)1.59567930
161Hypoglycemic seizures (HP:0002173)1.59512939
162Postnatal microcephaly (HP:0005484)1.58074979
163Unilateral renal agenesis (HP:0000122)1.57317356
164Renal agenesis (HP:0000104)1.55405472
165Absent eyelashes (HP:0000561)1.54568574
166Breast carcinoma (HP:0003002)1.52896271
167Hypoplasia of the uterus (HP:0000013)1.52307003
168Patellar aplasia (HP:0006443)1.51390498
169Shoulder girdle muscle weakness (HP:0003547)1.51275878
170Preaxial hand polydactyly (HP:0001177)1.51259684
171Abnormality of the clitoris (HP:0000056)1.51187685
172Oral leukoplakia (HP:0002745)1.51027570
173Ovarian neoplasm (HP:0100615)1.50430634
174Embryonal neoplasm (HP:0002898)1.48912231
175Benign neoplasm of the central nervous system (HP:0100835)1.48828845
176Absent thumb (HP:0009777)1.48521206
177Choanal atresia (HP:0000453)1.47825816
178Capillary hemangiomas (HP:0005306)1.47789696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.16402562
2MKNK25.52607168
3GRK54.60540938
4GRK64.26555540
5ERN14.24295109
6MKNK13.73700897
7GRK13.41152040
8ADRBK23.06897986
9TTK2.76216955
10TRIM282.64908402
11CSF1R2.52549370
12EPHA22.46395645
13TGFBR22.41591932
14GRK72.37009144
15MAPK72.35300476
16ZAK2.28038448
17TSSK62.24261934
18BRSK22.20888392
19TNIK2.09982193
20PLK42.01747376
21STK101.98786220
22PLK31.87232533
23AKT31.85534667
24MATK1.74393712
25BCKDK1.74108820
26CDK71.63236484
27STK31.61174124
28MOS1.60422010
29ERBB31.60373027
30EPHA41.47181622
31EIF2AK11.46243436
32TYRO31.42826169
33MAP2K41.40528064
34MAP3K41.39456193
35CAMK41.38150300
36MAP4K21.34500672
37PRKG21.31060764
38PLK11.30771584
39BMPR1B1.30738929
40WNK11.28264970
41NUAK11.25509248
42BRD41.24144208
43TAF11.24131625
44PAK41.18531147
45VRK11.16918782
46MAP2K61.16158167
47ADRBK11.14524154
48EIF2AK21.13961825
49EIF2AK31.10907616
50YES11.10443524
51CHEK21.07545370
52BRSK11.04734976
53ACVR1B1.03400951
54MAP3K101.03142873
55STK241.02818435
56MST1R0.99892710
57CASK0.97467584
58AKT20.92408720
59DYRK30.91273077
60MAP2K70.90983773
61WEE10.90730081
62VRK20.90262716
63STK38L0.90163985
64CCNB10.89595359
65STK390.84557064
66NME10.83299118
67PRKCI0.82591447
68MST40.81802363
69NEK10.81459558
70SRPK10.79996432
71PBK0.79659195
72RPS6KA40.79490032
73CSK0.79104801
74RPS6KB20.78315669
75BUB10.77707628
76STK160.75076504
77INSRR0.73657695
78PLK20.71028473
79TGFBR10.70681463
80AURKB0.69923519
81CHEK10.69682765
82FGFR30.68281325
83ERBB40.67798728
84MARK20.64817935
85AURKA0.64257050
86DYRK20.63318401
87CDK80.62334522
88SIK10.61697164
89MAPKAPK30.61696662
90MAPK120.61276882
91HIPK20.61152851
92MAP3K80.59542217
93BRAF0.59469018
94MAP3K70.58043088
95ERBB20.53191043
96NEK20.52607128
97TIE10.51011404
98PNCK0.50167837
99CSNK1G10.49949647
100TAOK10.49922500
101CDC70.49555948
102CDK40.48322378
103CSNK1E0.47174975
104MELK0.46861930
105TAOK20.45019665
106CLK10.42675179
107MAP3K30.42369600
108CDK20.41394227
109MAPK40.40376716
110ATM0.40146719
111WNK30.39970335
112FRK0.39509549
113CDK30.38853047
114PRKD30.38063445
115FGFR10.37220846
116ITK0.37104782
117PASK0.36933039
118NME20.36571598
119MARK30.36353494
120IGF1R0.36062047
121SIK30.35647273
122NTRK10.34405530
123PDK20.33566489
124MTOR0.33153518
125CSNK1A1L0.33031572
126PTK20.32888609
127TLK10.32733176
128LATS10.32321199
129MAPK130.31163828
130PRKCD0.31050495
131FGFR40.30578299
132DYRK1B0.30031716
133CSNK1G30.28396730
134IKBKB0.28010079
135LATS20.27732146
136GSK3A0.27402087
137PRKACG0.26951684
138CHUK0.26464413
139ATR0.25995460
140CDK60.25802380
141MINK10.25526433
142RPS6KB10.25381591
143PDK40.25291970
144PDK30.25291970
145STK40.25224608
146MAP3K90.24502565
147CSNK2A10.23377433
148ABL20.23155030
149FLT30.22673592
150PRKAA10.22545432
151CSNK1G20.22335038
152CDK10.22166659
153DYRK1A0.22038344
154TESK20.20636098
155PRKDC0.20554403
156CSNK2A20.20278612
157PAK10.19402105
158MET0.19193093
159BCR0.18976022

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.69583991
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.92630702
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.73411124
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.63686640
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61912615
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42530660
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.39278841
8Tryptophan metabolism_Homo sapiens_hsa003802.37299253
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.28117643
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25965209
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19492070
12Chemical carcinogenesis_Homo sapiens_hsa052042.10539883
13Fructose and mannose metabolism_Homo sapiens_hsa000512.06661746
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02037782
15Arginine biosynthesis_Homo sapiens_hsa002201.98418920
16Complement and coagulation cascades_Homo sapiens_hsa046101.89435432
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.89157601
18One carbon pool by folate_Homo sapiens_hsa006701.87823436
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73621136
20Folate biosynthesis_Homo sapiens_hsa007901.71724504
21Fatty acid degradation_Homo sapiens_hsa000711.71203668
22Retinol metabolism_Homo sapiens_hsa008301.68548613
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67858035
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.65277664
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.64694975
26Protein export_Homo sapiens_hsa030601.63733026
27Peroxisome_Homo sapiens_hsa041461.62426581
28Selenocompound metabolism_Homo sapiens_hsa004501.55513564
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54269545
30Oocyte meiosis_Homo sapiens_hsa041141.53648375
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50362445
32Butanoate metabolism_Homo sapiens_hsa006501.48896998
33Ribosome_Homo sapiens_hsa030101.47629334
34Nitrogen metabolism_Homo sapiens_hsa009101.46034913
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40280705
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.37866004
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.36168394
38Biosynthesis of amino acids_Homo sapiens_hsa012301.33742057
39Galactose metabolism_Homo sapiens_hsa000521.33480942
40Carbon metabolism_Homo sapiens_hsa012001.33245237
41Arachidonic acid metabolism_Homo sapiens_hsa005901.32194396
42Linoleic acid metabolism_Homo sapiens_hsa005911.29745769
43Histidine metabolism_Homo sapiens_hsa003401.29635543
44Propanoate metabolism_Homo sapiens_hsa006401.24473284
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21241305
46beta-Alanine metabolism_Homo sapiens_hsa004101.20922189
47Purine metabolism_Homo sapiens_hsa002301.19228984
48Pyruvate metabolism_Homo sapiens_hsa006201.15527562
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14290860
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11661804
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11326068
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11253280
53PPAR signaling pathway_Homo sapiens_hsa033201.10872360
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09446585
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09309298
56Sulfur relay system_Homo sapiens_hsa041221.07551853
57Phenylalanine metabolism_Homo sapiens_hsa003601.06136258
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01681209
59Tyrosine metabolism_Homo sapiens_hsa003501.00355141
60RNA transport_Homo sapiens_hsa030130.98382425
61Fatty acid metabolism_Homo sapiens_hsa012120.97521108
62TGF-beta signaling pathway_Homo sapiens_hsa043500.97334817
63Pentose phosphate pathway_Homo sapiens_hsa000300.96962602
64Fatty acid elongation_Homo sapiens_hsa000620.92859982
65Starch and sucrose metabolism_Homo sapiens_hsa005000.91603272
66Glutathione metabolism_Homo sapiens_hsa004800.90481460
67Fat digestion and absorption_Homo sapiens_hsa049750.89939844
68Hippo signaling pathway_Homo sapiens_hsa043900.87911965
69Mismatch repair_Homo sapiens_hsa034300.85392930
70Caffeine metabolism_Homo sapiens_hsa002320.83397508
71DNA replication_Homo sapiens_hsa030300.82972912
72Steroid biosynthesis_Homo sapiens_hsa001000.82355349
73Proteasome_Homo sapiens_hsa030500.82130144
74Bile secretion_Homo sapiens_hsa049760.81661766
75Vitamin digestion and absorption_Homo sapiens_hsa049770.81586844
76Arginine and proline metabolism_Homo sapiens_hsa003300.80077407
77ABC transporters_Homo sapiens_hsa020100.77530189
78RNA polymerase_Homo sapiens_hsa030200.76617713
79Alcoholism_Homo sapiens_hsa050340.76427499
80Homologous recombination_Homo sapiens_hsa034400.74676244
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74252171
82Circadian rhythm_Homo sapiens_hsa047100.72128997
83Metabolic pathways_Homo sapiens_hsa011000.71162582
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70118295
85Pyrimidine metabolism_Homo sapiens_hsa002400.70108582
86MicroRNAs in cancer_Homo sapiens_hsa052060.69301627
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.69248828
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67667974
89Fanconi anemia pathway_Homo sapiens_hsa034600.62258581
90Staphylococcus aureus infection_Homo sapiens_hsa051500.59129572
91Sulfur metabolism_Homo sapiens_hsa009200.56815068
92Glycerolipid metabolism_Homo sapiens_hsa005610.56454464
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56256788
94Wnt signaling pathway_Homo sapiens_hsa043100.56152758
95Lysine degradation_Homo sapiens_hsa003100.54861196
96Spliceosome_Homo sapiens_hsa030400.49933775
97Hedgehog signaling pathway_Homo sapiens_hsa043400.48841523
98Base excision repair_Homo sapiens_hsa034100.47158364
99Phototransduction_Homo sapiens_hsa047440.46759026
100RNA degradation_Homo sapiens_hsa030180.45907553
101Adherens junction_Homo sapiens_hsa045200.45716906
102Basal cell carcinoma_Homo sapiens_hsa052170.44816081
103Systemic lupus erythematosus_Homo sapiens_hsa053220.44809723
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43774638
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41181375
106Thyroid cancer_Homo sapiens_hsa052160.39811262
107Huntingtons disease_Homo sapiens_hsa050160.39346816
108Viral carcinogenesis_Homo sapiens_hsa052030.39023181
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38739540
110Prostate cancer_Homo sapiens_hsa052150.37501699
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36326829
112Nucleotide excision repair_Homo sapiens_hsa034200.36214483
113N-Glycan biosynthesis_Homo sapiens_hsa005100.36052970
114Colorectal cancer_Homo sapiens_hsa052100.35782534
115mRNA surveillance pathway_Homo sapiens_hsa030150.34642098
116Cell cycle_Homo sapiens_hsa041100.34353683
117Taste transduction_Homo sapiens_hsa047420.33987226
118Regulation of autophagy_Homo sapiens_hsa041400.33753706
119Olfactory transduction_Homo sapiens_hsa047400.30893024
120Epstein-Barr virus infection_Homo sapiens_hsa051690.30755066
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30573475
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30053333
123Non-homologous end-joining_Homo sapiens_hsa034500.28803862
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25932467
125AMPK signaling pathway_Homo sapiens_hsa041520.25066726
126p53 signaling pathway_Homo sapiens_hsa041150.24972106
127Ether lipid metabolism_Homo sapiens_hsa005650.24566511
128Tight junction_Homo sapiens_hsa045300.23733540
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23455232
130Basal transcription factors_Homo sapiens_hsa030220.23409334
131Nicotine addiction_Homo sapiens_hsa050330.22851108
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22094559
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.21829898
134FoxO signaling pathway_Homo sapiens_hsa040680.21110692
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20859667
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20791908
137Parkinsons disease_Homo sapiens_hsa050120.20768774
138Melanoma_Homo sapiens_hsa052180.19807955
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13688889
140Long-term depression_Homo sapiens_hsa047300.12222548
141Oxidative phosphorylation_Homo sapiens_hsa001900.12177858
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12023027

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