GRM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.91961014
2vocalization behavior (GO:0071625)5.53295395
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38250531
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.35560327
5neuron cell-cell adhesion (GO:0007158)5.16203637
6synaptic vesicle exocytosis (GO:0016079)5.06957312
7protein localization to synapse (GO:0035418)5.06853358
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.93589777
9regulation of glutamate receptor signaling pathway (GO:1900449)4.92661550
10locomotory exploration behavior (GO:0035641)4.87674740
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.79911356
12glutamate secretion (GO:0014047)4.72639429
13synaptic vesicle maturation (GO:0016188)4.72459637
14behavioral response to nicotine (GO:0035095)4.69465163
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.67714356
16regulation of synaptic vesicle exocytosis (GO:2000300)4.67613582
17pyrimidine nucleobase catabolic process (GO:0006208)4.67375727
18* glutamate receptor signaling pathway (GO:0007215)4.57009630
19synaptic transmission, glutamatergic (GO:0035249)4.50754151
20neuronal action potential propagation (GO:0019227)4.44851487
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.42285503
22neuron-neuron synaptic transmission (GO:0007270)4.36009085
23neurotransmitter-gated ion channel clustering (GO:0072578)4.33986614
24presynaptic membrane assembly (GO:0097105)4.32307274
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.15807908
26exploration behavior (GO:0035640)4.14524581
27regulation of synaptic vesicle transport (GO:1902803)4.13725844
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.06934234
29regulation of neuronal synaptic plasticity (GO:0048168)4.04960758
30presynaptic membrane organization (GO:0097090)4.02991413
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.02714204
32C4-dicarboxylate transport (GO:0015740)4.01912003
33regulation of excitatory postsynaptic membrane potential (GO:0060079)4.00731528
34neurotransmitter secretion (GO:0007269)3.98107679
35neuron recognition (GO:0008038)3.93944547
36nucleobase catabolic process (GO:0046113)3.86490046
37positive regulation of synapse maturation (GO:0090129)3.84860456
38postsynaptic membrane organization (GO:0001941)3.84447529
39regulation of postsynaptic membrane potential (GO:0060078)3.83763729
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.72795897
41long-term memory (GO:0007616)3.72328364
42positive regulation of membrane potential (GO:0045838)3.71323730
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.70712923
44regulation of dendritic spine morphogenesis (GO:0061001)3.69238289
45response to histamine (GO:0034776)3.68721262
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68209648
47regulation of synapse structural plasticity (GO:0051823)3.63632216
48dendritic spine morphogenesis (GO:0060997)3.62934159
49epithelial cilium movement (GO:0003351)3.61647495
50* regulation of synaptic transmission, glutamatergic (GO:0051966)3.61163207
51retinal cone cell development (GO:0046549)3.60363202
52gamma-aminobutyric acid transport (GO:0015812)3.57826579
53regulation of synaptic plasticity (GO:0048167)3.56320474
54regulation of cilium movement (GO:0003352)3.55981524
55* G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.54909734
56axonal fasciculation (GO:0007413)3.53239495
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.51373579
58positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.46541090
59layer formation in cerebral cortex (GO:0021819)3.46504042
60long-term synaptic potentiation (GO:0060291)3.45397606
61* transmission of nerve impulse (GO:0019226)3.43608984
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.39938823
63cellular potassium ion homeostasis (GO:0030007)3.39426808
64response to pheromone (GO:0019236)3.39162918
65neurotransmitter transport (GO:0006836)3.38428230
66regulation of vesicle fusion (GO:0031338)3.37970598
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.37320972
68cerebellar granule cell differentiation (GO:0021707)3.35916162
69membrane depolarization (GO:0051899)3.35313027
70membrane depolarization during action potential (GO:0086010)3.35225999
71cerebellar Purkinje cell differentiation (GO:0021702)3.33686579
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.31146352
73regulation of neurotransmitter secretion (GO:0046928)3.31096045
74cilium or flagellum-dependent cell motility (GO:0001539)3.30155346
75startle response (GO:0001964)3.28796880
76detection of light stimulus involved in sensory perception (GO:0050962)3.28220253
77detection of light stimulus involved in visual perception (GO:0050908)3.28220253
78* behavioral defense response (GO:0002209)3.25087632
79* behavioral fear response (GO:0001662)3.25087632
80nonmotile primary cilium assembly (GO:0035058)3.25037821
81protein localization to cilium (GO:0061512)3.24820864
82proline transport (GO:0015824)3.24737563
83regulation of action potential (GO:0098900)3.24462497
84regulation of dendritic spine development (GO:0060998)3.21460236
85neuronal action potential (GO:0019228)3.21061818
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.20949069
87cilium movement (GO:0003341)3.20787227
88axoneme assembly (GO:0035082)3.18211666
89positive regulation of synapse assembly (GO:0051965)3.16275180
90fucose catabolic process (GO:0019317)3.16223773
91L-fucose metabolic process (GO:0042354)3.16223773
92L-fucose catabolic process (GO:0042355)3.16223773
93auditory behavior (GO:0031223)3.13591911
94positive regulation of neurotransmitter secretion (GO:0001956)3.13475227
95positive regulation of dendritic spine morphogenesis (GO:0061003)3.12680158
96regulation of synapse maturation (GO:0090128)3.12248204
97synapse assembly (GO:0007416)3.12087425
98activation of protein kinase A activity (GO:0034199)3.10884123
99* learning (GO:0007612)3.10487147
100regulation of neurotransmitter levels (GO:0001505)3.10141428
101membrane hyperpolarization (GO:0060081)3.08211533
102* fear response (GO:0042596)3.08040355
103dendrite morphogenesis (GO:0048813)3.07745532
104neuronal ion channel clustering (GO:0045161)3.06560282
105* synaptic transmission (GO:0007268)3.05146896
106neuromuscular process controlling balance (GO:0050885)3.04518381
107regulation of neurotransmitter transport (GO:0051588)3.04226583
108positive regulation of dendritic spine development (GO:0060999)3.02392968
109response to auditory stimulus (GO:0010996)3.02320913
110synaptic vesicle endocytosis (GO:0048488)3.01936779
111* regulation of synaptic transmission (GO:0050804)3.01175403
112regulation of female receptivity (GO:0045924)2.99658298
113adult walking behavior (GO:0007628)2.99621706
114neuromuscular process controlling posture (GO:0050884)2.97622268
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97593128
116positive regulation of neurotransmitter transport (GO:0051590)2.97358822
117positive regulation of synaptic transmission (GO:0050806)2.96929813
118behavioral response to cocaine (GO:0048148)2.96892408
119negative regulation of dendrite morphogenesis (GO:0050774)2.94419344
120dendritic spine organization (GO:0097061)2.93125815
121protein polyglutamylation (GO:0018095)2.91947548
122central nervous system projection neuron axonogenesis (GO:0021952)2.89962360
123mechanosensory behavior (GO:0007638)2.88224759
124innervation (GO:0060384)2.86954156
125regulation of protein kinase A signaling (GO:0010738)2.86218268
126neuromuscular synaptic transmission (GO:0007274)2.85876912
127negative regulation of dendrite development (GO:2000171)2.85511722
128glycosphingolipid biosynthetic process (GO:0006688)2.83717935
129behavioral response to ethanol (GO:0048149)2.83558227
130neural tube formation (GO:0001841)2.83544478
131neurofilament cytoskeleton organization (GO:0060052)2.80115155
132cilium morphogenesis (GO:0060271)2.77750978
133* short-term memory (GO:0007614)2.73467571
134axonemal dynein complex assembly (GO:0070286)2.73078280
135regulation of collateral sprouting (GO:0048670)2.72285299
136detection of mechanical stimulus involved in sensory perception (GO:0050974)2.68170766
137platelet dense granule organization (GO:0060155)2.67132865
138inner ear receptor stereocilium organization (GO:0060122)2.63132887
139regulation of microtubule-based movement (GO:0060632)2.61925540
140serotonin metabolic process (GO:0042428)2.61602694
141calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.60345744
142cAMP catabolic process (GO:0006198)2.59376478
143regulation of feeding behavior (GO:0060259)2.58640174
144central nervous system neuron axonogenesis (GO:0021955)2.56871439
145regulation of calcium ion-dependent exocytosis (GO:0017158)2.56519583
146regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56243289
147cilium organization (GO:0044782)2.53481373
148synaptic transmission, cholinergic (GO:0007271)2.52828647
149positive regulation of amino acid transport (GO:0051957)2.52395293
150cilium assembly (GO:0042384)2.51709676
151negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51317802
152primary amino compound metabolic process (GO:1901160)2.50748622
153retinal ganglion cell axon guidance (GO:0031290)2.49792979
154negative regulation of response to food (GO:0032096)2.48070703
155negative regulation of appetite (GO:0032099)2.48070703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.19246341
2GBX2_23144817_ChIP-Seq_PC3_Human4.17276124
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15845198
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09949950
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08608729
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64583801
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62729501
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62729501
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60998709
10REST_21632747_ChIP-Seq_MESCs_Mouse2.58776999
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.54281562
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53060250
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49409564
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44678459
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39974245
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.39473541
17TAF15_26573619_Chip-Seq_HEK293_Human2.38878118
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.31474678
19DROSHA_22980978_ChIP-Seq_HELA_Human2.26246506
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16145577
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.15625188
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.10899213
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08755746
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.07308854
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03264988
26* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96488239
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95503776
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95229703
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.89149672
30AR_21572438_ChIP-Seq_LNCaP_Human1.87683520
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87226573
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86470999
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84640814
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78845156
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.77496017
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77262113
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74003890
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71492470
39* EWS_26573619_Chip-Seq_HEK293_Human1.70129519
40P300_19829295_ChIP-Seq_ESCs_Human1.64861929
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61878739
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59881327
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59367970
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58902586
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54406538
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53782474
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52425919
48CBP_20019798_ChIP-Seq_JUKART_Human1.52425919
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.50185071
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45209344
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45203588
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.44753828
53ZNF274_21170338_ChIP-Seq_K562_Hela1.40427289
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.38671355
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35660288
56* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35633140
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35431278
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35043119
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34957830
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34595146
61* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33892915
62* STAT3_23295773_ChIP-Seq_U87_Human1.31905764
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.31429681
64* PIAS1_25552417_ChIP-Seq_VCAP_Human1.30605677
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29949477
66* AR_25329375_ChIP-Seq_VCAP_Human1.29817352
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29374370
68FUS_26573619_Chip-Seq_HEK293_Human1.28845469
69RNF2_27304074_Chip-Seq_NSC_Mouse1.27921185
70VDR_22108803_ChIP-Seq_LS180_Human1.27587066
71TP53_22573176_ChIP-Seq_HFKS_Human1.26948055
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26462752
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.26143499
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25712690
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23791029
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22878800
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22648397
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22125642
79IGF1R_20145208_ChIP-Seq_DFB_Human1.21543045
80TCF4_22108803_ChIP-Seq_LS180_Human1.20925107
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.19911477
82* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18960345
83* TCF4_23295773_ChIP-Seq_U87_Human1.17015268
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.15852951
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15149539
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14136798
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13930537
88* AR_19668381_ChIP-Seq_PC3_Human1.13577040
89SOX2_19829295_ChIP-Seq_ESCs_Human1.13018886
90NANOG_19829295_ChIP-Seq_ESCs_Human1.13018886
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12552959
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.12541053
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12156122
94AHR_22903824_ChIP-Seq_MCF-7_Human1.12046210
95IRF1_19129219_ChIP-ChIP_H3396_Human1.11708391
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11108527
97P53_22387025_ChIP-Seq_ESCs_Mouse1.10846416
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.09101675
99RUNX2_22187159_ChIP-Seq_PCA_Human1.08253735
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.07992245
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.07929392
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07497017
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.07349143
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07263153
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06084495
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05945105
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05648396
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05348431
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05348431
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.05078218
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04603614
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04430166
113* ER_23166858_ChIP-Seq_MCF-7_Human1.03601272
114JUN_21703547_ChIP-Seq_K562_Human1.03197690
115* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01000123
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.00317613
117RING1B_27294783_Chip-Seq_NPCs_Mouse1.00225155
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99975802
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99868087
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99238554
121* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99072269
122NANOG_18555785_Chip-Seq_ESCs_Mouse0.99047514
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98869923
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96684172
125TP53_16413492_ChIP-PET_HCT116_Human0.96425012
126TP53_18474530_ChIP-ChIP_U2OS_Human0.95466360
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95319782
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95179750
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.90564034
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90409747
131* KDM2B_26808549_Chip-Seq_REH_Human0.88394230
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88064504
133BCAT_22108803_ChIP-Seq_LS180_Human0.87178926
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.86655433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.96489766
2MP0003880_abnormal_central_pattern5.56608909
3* MP0003635_abnormal_synaptic_transmissio4.03636030
4MP0004270_analgesia3.63083827
5MP0001968_abnormal_touch/_nociception3.58263117
6* MP0009745_abnormal_behavioral_response3.53369756
7* MP0002063_abnormal_learning/memory/cond3.24171222
8* MP0002064_seizures3.13601538
9MP0009046_muscle_twitch2.97875600
10MP0002735_abnormal_chemical_nociception2.97439179
11MP0002736_abnormal_nociception_after2.90324081
12MP0002572_abnormal_emotion/affect_behav2.86068662
13MP0005423_abnormal_somatic_nervous2.77933734
14MP0002272_abnormal_nervous_system2.76068106
15MP0002734_abnormal_mechanical_nocicepti2.72626734
16MP0002822_catalepsy2.63357479
17MP0001486_abnormal_startle_reflex2.49503475
18MP0001440_abnormal_grooming_behavior2.38051892
19MP0008877_abnormal_DNA_methylation2.37290665
20MP0001501_abnormal_sleep_pattern2.35760399
21MP0002733_abnormal_thermal_nociception2.17984469
22MP0001970_abnormal_pain_threshold2.13913246
23MP0002067_abnormal_sensory_capabilities2.12750813
24MP0006276_abnormal_autonomic_nervous2.09920529
25MP0002102_abnormal_ear_morphology2.00303131
26MP0000778_abnormal_nervous_system1.91420781
27MP0002184_abnormal_innervation1.85506602
28MP0003329_amyloid_beta_deposits1.83441729
29MP0009780_abnormal_chondrocyte_physiolo1.77791475
30MP0001529_abnormal_vocalization1.71500955
31MP0003879_abnormal_hair_cell1.70087546
32MP0002557_abnormal_social/conspecific_i1.68835446
33MP0004924_abnormal_behavior1.68745486
34MP0005386_behavior/neurological_phenoty1.68745486
35MP0008569_lethality_at_weaning1.62577705
36MP0008789_abnormal_olfactory_epithelium1.59485713
37MP0000569_abnormal_digit_pigmentation1.56331346
38MP0004142_abnormal_muscle_tone1.53672890
39MP0004811_abnormal_neuron_physiology1.53106027
40MP0005646_abnormal_pituitary_gland1.52967917
41MP0003195_calcinosis1.51928954
42MP0004858_abnormal_nervous_system1.49942016
43MP0003787_abnormal_imprinting1.48016902
44MP0000955_abnormal_spinal_cord1.47361350
45MP0004043_abnormal_pH_regulation1.45474615
46MP0001984_abnormal_olfaction1.44935219
47MP0005253_abnormal_eye_physiology1.43607726
48MP0001905_abnormal_dopamine_level1.42256784
49MP0002882_abnormal_neuron_morphology1.42219918
50MP0006292_abnormal_olfactory_placode1.41200634
51* MP0002066_abnormal_motor_capabilities/c1.38503563
52MP0001188_hyperpigmentation1.37001919
53MP0004885_abnormal_endolymph1.35255355
54MP0002909_abnormal_adrenal_gland1.34534126
55MP0003121_genomic_imprinting1.32522613
56MP0001502_abnormal_circadian_rhythm1.32368811
57MP0005645_abnormal_hypothalamus_physiol1.26870523
58MP0003122_maternal_imprinting1.26378702
59MP0003633_abnormal_nervous_system1.24897602
60MP0002653_abnormal_ependyma_morphology1.23190223
61MP0003136_yellow_coat_color1.16639468
62MP0008875_abnormal_xenobiotic_pharmacok1.15193685
63MP0003631_nervous_system_phenotype1.10685760
64MP0005084_abnormal_gallbladder_morpholo1.10683244
65MP0004742_abnormal_vestibular_system1.09367189
66MP0005551_abnormal_eye_electrophysiolog1.08137820
67MP0005171_absent_coat_pigmentation1.05913875
68MP0005410_abnormal_fertilization1.04214080
69MP0002229_neurodegeneration1.03507937
70MP0002152_abnormal_brain_morphology1.03283022
71MP0002876_abnormal_thyroid_physiology1.02166532
72MP0004147_increased_porphyrin_level1.00550259
73MP0003011_delayed_dark_adaptation1.00175231
74MP0002234_abnormal_pharynx_morphology0.99899151
75MP0010386_abnormal_urinary_bladder0.99598642
76MP0004145_abnormal_muscle_electrophysio0.96866824
77MP0000751_myopathy0.95818999
78MP0002837_dystrophic_cardiac_calcinosis0.95584956
79MP0000920_abnormal_myelination0.95557195
80MP0005187_abnormal_penis_morphology0.95303258
81MP0008995_early_reproductive_senescence0.92416846
82MP0004133_heterotaxia0.92375665
83MP0001963_abnormal_hearing_physiology0.91335507
84MP0000372_irregular_coat_pigmentation0.91117212
85MP0008874_decreased_physiological_sensi0.89858999
86MP0002160_abnormal_reproductive_system0.88710684
87MP0001485_abnormal_pinna_reflex0.88632543
88MP0008872_abnormal_physiological_respon0.88121274
89MP0004085_abnormal_heartbeat0.86498002
90MP0002069_abnormal_eating/drinking_beha0.86427815
91MP0002752_abnormal_somatic_nervous0.84638524
92MP0003632_abnormal_nervous_system0.83534493
93MP0003698_abnormal_male_reproductive0.83526119
94MP0000427_abnormal_hair_cycle0.83480920
95MP0005195_abnormal_posterior_eye0.82845068
96MP0003634_abnormal_glial_cell0.82259983
97MP0005409_darkened_coat_color0.80740591
98MP0003690_abnormal_glial_cell0.80305044
99MP0000604_amyloidosis0.80105583
100MP0005535_abnormal_body_temperature0.78111504
101MP0000647_abnormal_sebaceous_gland0.76480494
102MP0001177_atelectasis0.76153225
103MP0002233_abnormal_nose_morphology0.75238979
104MP0002928_abnormal_bile_duct0.73186028
105MP0000631_abnormal_neuroendocrine_gland0.69387392
106MP0003567_abnormal_fetal_cardiomyocyte0.68826644
107MP0003718_maternal_effect0.68383633
108MP0004215_abnormal_myocardial_fiber0.68179746
109MP0004484_altered_response_of0.66642866
110MP0000026_abnormal_inner_ear0.61346242
111MP0001986_abnormal_taste_sensitivity0.60450164
112MP0003183_abnormal_peptide_metabolism0.59899930
113MP0002090_abnormal_vision0.59735309
114MP0001664_abnormal_digestion0.59684667
115MP0005394_taste/olfaction_phenotype0.57268994
116MP0005499_abnormal_olfactory_system0.57268994
117MP0000013_abnormal_adipose_tissue0.56165815
118MP0001943_abnormal_respiration0.55964180
119MP0001299_abnormal_eye_distance/0.55589132
120MP0003137_abnormal_impulse_conducting0.55460303
121MP0003075_altered_response_to0.53412291
122MP0002638_abnormal_pupillary_reflex0.52612661
123MP0002751_abnormal_autonomic_nervous0.49919585
124MP0003861_abnormal_nervous_system0.49655565
125MP0005623_abnormal_meninges_morphology0.49419528
126MP0002082_postnatal_lethality0.49370161
127MP0010770_preweaning_lethality0.49370161
128MP0010769_abnormal_survival0.48962034
129MP0006072_abnormal_retinal_apoptosis0.47627491
130MP0001765_abnormal_ion_homeostasis0.47065267

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.54810013
2Myokymia (HP:0002411)6.23089129
3Focal seizures (HP:0007359)6.16018578
4Atonic seizures (HP:0010819)5.69372426
5Epileptic encephalopathy (HP:0200134)5.30063944
6Febrile seizures (HP:0002373)4.91573390
7Absence seizures (HP:0002121)4.62236142
8Visual hallucinations (HP:0002367)4.50488193
9Dialeptic seizures (HP:0011146)4.49858020
10Hyperventilation (HP:0002883)4.28806618
11Progressive cerebellar ataxia (HP:0002073)4.25124420
12Generalized tonic-clonic seizures (HP:0002069)4.09140545
13Broad-based gait (HP:0002136)3.94697479
14Pancreatic cysts (HP:0001737)3.72942738
15Medial flaring of the eyebrow (HP:0010747)3.59352846
16Gaze-evoked nystagmus (HP:0000640)3.44268304
17Molar tooth sign on MRI (HP:0002419)3.40145690
18Abnormality of midbrain morphology (HP:0002418)3.40145690
19True hermaphroditism (HP:0010459)3.31326865
20Action tremor (HP:0002345)3.30913281
21Supranuclear gaze palsy (HP:0000605)3.26173094
22Amblyopia (HP:0000646)3.24514044
23Pancreatic fibrosis (HP:0100732)3.24334213
24Dysdiadochokinesis (HP:0002075)3.23959164
25Poor eye contact (HP:0000817)3.21779071
26Dysmetria (HP:0001310)3.17556198
27Truncal ataxia (HP:0002078)3.11520890
28Impaired vibration sensation in the lower limbs (HP:0002166)3.03820718
29Ankle clonus (HP:0011448)3.03526641
30Scanning speech (HP:0002168)2.99079868
31Nephrogenic diabetes insipidus (HP:0009806)2.96815859
32Abnormal eating behavior (HP:0100738)2.94647768
33Excessive salivation (HP:0003781)2.91017730
34Drooling (HP:0002307)2.91017730
35Abnormal social behavior (HP:0012433)2.88653102
36Impaired social interactions (HP:0000735)2.88653102
37Nephronophthisis (HP:0000090)2.88255558
38Urinary bladder sphincter dysfunction (HP:0002839)2.83290858
39Absent/shortened dynein arms (HP:0200106)2.82528184
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.82528184
41Genital tract atresia (HP:0001827)2.77536546
42Progressive inability to walk (HP:0002505)2.76023184
43Neurofibrillary tangles (HP:0002185)2.74733890
44Epileptiform EEG discharges (HP:0011182)2.74456157
45Anxiety (HP:0000739)2.73039614
46Vaginal atresia (HP:0000148)2.71142990
47Depression (HP:0000716)2.67754815
48Abnormality of the corticospinal tract (HP:0002492)2.66883514
49Spastic gait (HP:0002064)2.65904396
50Abnormal respiratory motile cilium morphology (HP:0005938)2.65670719
51Abnormal respiratory epithelium morphology (HP:0012253)2.65670719
52Cerebral inclusion bodies (HP:0100314)2.64909379
53Abnormality of the lower motor neuron (HP:0002366)2.60010754
54Lissencephaly (HP:0001339)2.59184624
55Absent speech (HP:0001344)2.58311277
56Abnormal ciliary motility (HP:0012262)2.58079782
57Urinary urgency (HP:0000012)2.54696746
58Genetic anticipation (HP:0003743)2.54631860
59Insidious onset (HP:0003587)2.53279136
60Termporal pattern (HP:0011008)2.53279136
61Postural instability (HP:0002172)2.51399357
62Mutism (HP:0002300)2.51123360
63Abnormality of the renal medulla (HP:0100957)2.50678800
64Congenital stationary night blindness (HP:0007642)2.50078929
65Hemiparesis (HP:0001269)2.47779205
66EEG with generalized epileptiform discharges (HP:0011198)2.47068302
67Inability to walk (HP:0002540)2.46213474
68Abnormality of binocular vision (HP:0011514)2.44385113
69Diplopia (HP:0000651)2.44385113
70Polyphagia (HP:0002591)2.40913689
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.38267332
72Impaired smooth pursuit (HP:0007772)2.34510133
73Abnormal respiratory motile cilium physiology (HP:0012261)2.34339301
74Protruding tongue (HP:0010808)2.31458040
75Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.31081327
76Fetal akinesia sequence (HP:0001989)2.31070222
77Abnormality of the renal cortex (HP:0011035)2.30048799
78Stereotypic behavior (HP:0000733)2.27101022
79Blue irides (HP:0000635)2.27078753
80Pachygyria (HP:0001302)2.26452562
81Abnormality of the labia minora (HP:0012880)2.26334403
82Hypsarrhythmia (HP:0002521)2.24285464
83Cystic liver disease (HP:0006706)2.23070565
84Chronic hepatic failure (HP:0100626)2.21023869
85Torticollis (HP:0000473)2.20926693
86Bradykinesia (HP:0002067)2.20142371
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19615411
88Generalized myoclonic seizures (HP:0002123)2.19363360
89Degeneration of the lateral corticospinal tracts (HP:0002314)2.17041188
90Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17041188
91Lower limb muscle weakness (HP:0007340)2.16769138
92Status epilepticus (HP:0002133)2.16438098
93Poor coordination (HP:0002370)2.15744415
94Postaxial hand polydactyly (HP:0001162)2.13806903
95Intention tremor (HP:0002080)2.12294812
96Gait imbalance (HP:0002141)2.10419561
97Akinesia (HP:0002304)2.08622881
98Pheochromocytoma (HP:0002666)2.08006451
99Dysmetric saccades (HP:0000641)2.06625990
100Renal cortical cysts (HP:0000803)2.06559849
101Decreased central vision (HP:0007663)2.05880027
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.05729704
103Attenuation of retinal blood vessels (HP:0007843)2.05692773
104Abnormality of macular pigmentation (HP:0008002)2.04107507
105Impaired vibratory sensation (HP:0002495)2.02913661
106Increased circulating renin level (HP:0000848)2.02909184
107Short tibia (HP:0005736)2.02539568
108Spastic tetraplegia (HP:0002510)2.02344264
109Abnormality of ocular smooth pursuit (HP:0000617)2.01244069
110Focal dystonia (HP:0004373)2.00873444
111Optic nerve hypoplasia (HP:0000609)1.98909107
112Abnormality of salivation (HP:0100755)1.98841603
113Cerebellar dysplasia (HP:0007033)1.95795157
114Postaxial foot polydactyly (HP:0001830)1.95673119
115Abolished electroretinogram (ERG) (HP:0000550)1.94525295
116Incomplete penetrance (HP:0003829)1.94507969
117Limb dystonia (HP:0002451)1.93506144
118Papilledema (HP:0001085)1.92439358
119Psychosis (HP:0000709)1.92391981
120Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91258403
121Hypoplasia of the brainstem (HP:0002365)1.91258403
122Retinal dysplasia (HP:0007973)1.91060858
123Acute necrotizing encephalopathy (HP:0006965)1.90975344
124Sclerocornea (HP:0000647)1.89095733
125Rhinitis (HP:0012384)1.89088068
126Bony spicule pigmentary retinopathy (HP:0007737)1.89025966
127Neuroendocrine neoplasm (HP:0100634)1.87581697
128Hemiplegia (HP:0002301)1.86854550
129Specific learning disability (HP:0001328)1.85661620
130Thickened helices (HP:0000391)1.85081056
131Tubulointerstitial nephritis (HP:0001970)1.84975613
132Craniofacial dystonia (HP:0012179)1.84837259
133Lower limb amyotrophy (HP:0007210)1.84713218
134Abnormal rod and cone electroretinograms (HP:0008323)1.84596816
135Sensory axonal neuropathy (HP:0003390)1.83285982
136Keratoconus (HP:0000563)1.83112625
137Increased corneal curvature (HP:0100692)1.83112625
138Gait ataxia (HP:0002066)1.81043652
139Pendular nystagmus (HP:0012043)1.80865625
140Decreased circulating renin level (HP:0003351)1.79647553
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77594032
142Polydipsia (HP:0001959)1.76755883
143Abnormal drinking behavior (HP:0030082)1.76755883
144Amyotrophic lateral sclerosis (HP:0007354)1.75785941
145Dyskinesia (HP:0100660)1.75516603
146Morphological abnormality of the pyramidal tract (HP:0002062)1.74121455
147Broad foot (HP:0001769)1.74067895
148Abnormality of saccadic eye movements (HP:0000570)1.73758911
149Abnormal hair whorl (HP:0010721)1.73627745
150Agitation (HP:0000713)1.73485226
151Delusions (HP:0000746)1.73194834
152Acute encephalopathy (HP:0006846)1.73189269
153Peripheral hypomyelination (HP:0007182)1.73037676
154Colon cancer (HP:0003003)1.72641491
155Occipital encephalocele (HP:0002085)1.72122758
156Progressive macrocephaly (HP:0004481)1.71598264
157Neuronal loss in central nervous system (HP:0002529)1.71478591
158Exotropia (HP:0000577)1.69637098
159Congenital primary aphakia (HP:0007707)1.67957324
160Type II lissencephaly (HP:0007260)1.66632101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.15402940
2NTRK35.06150004
3CASK3.74215300
4FRK3.59078283
5MAP3K93.21847742
6MARK12.84798983
7MAP3K42.70763270
8MAP4K22.62734775
9MAP2K72.51342683
10DAPK22.39255598
11MINK12.29475124
12TNIK2.28012006
13MAP3K122.01683136
14RIPK42.01089188
15NTRK21.99054160
16PINK11.94280881
17NTRK11.84414809
18TRIM281.81286580
19BMPR1B1.80306444
20KSR21.73528479
21PLK21.71525730
22MAP2K41.70180928
23PRPF4B1.69966604
24PAK61.69705329
25DAPK11.63035534
26CDK191.61865914
27MAPK131.58396488
28PNCK1.56949809
29DYRK21.53750005
30KSR11.51521792
31GRK11.51362646
32CSNK1G31.50837724
33CSNK1A1L1.44843440
34CDK51.43226771
35CSNK1G11.39292906
36ZAK1.35161981
37OXSR11.32620274
38EPHA31.31294802
39ARAF1.27977287
40INSRR1.27062073
41PRKCG1.24866414
42GRK51.23972813
43FES1.23099549
44CAMKK11.22759799
45CAMK2A1.19600694
46CAMK2B1.16401456
47CAMKK21.11829697
48NUAK11.09712400
49SIK21.09628735
50MAP3K20.99881872
51CSNK1G20.99121089
52UHMK10.96245087
53TAOK30.95644072
54SGK4940.95133086
55SGK2230.95133086
56MAP3K130.89188647
57MARK20.88844010
58ERBB30.88708694
59PRKD30.87068162
60STK390.86018992
61CDK180.85408120
62STK38L0.85239422
63CDK140.83401563
64PHKG10.82235987
65PHKG20.82235987
66CDK150.82226672
67AKT30.82064047
68PTK2B0.81039592
69BMPR20.79950659
70STK380.79563135
71STK110.76084024
72PRKCE0.75828763
73CAMK10.74098608
74NME10.73919544
75TYRO30.73616711
76CCNB10.73273357
77SGK10.72644370
78RAF10.71860366
79SGK20.71361230
80CDK11A0.70744545
81CAMK2D0.69152696
82CAMK40.66710085
83BCR0.65867317
84FGR0.65208808
85GRK70.65184200
86TIE10.63449485
87RPS6KA40.61665031
88PAK30.60943717
89ACVR1B0.59008685
90DYRK1A0.58613537
91CAMK2G0.57429518
92LATS20.57144396
93SIK30.55589746
94TXK0.55454508
95MKNK20.55033818
96PRKCH0.53632286
97VRK10.52786762
98TNK20.52338415
99MAPK150.52122757
100DYRK30.51064996
101PDPK10.50765918
102BRAF0.50497691
103NEK60.49803895
104PKN10.47973980
105RET0.47953055
106CSNK1A10.47919792
107FER0.47580450
108TAOK10.47477779
109PRKG10.47147263
110WNK10.46377874
111FYN0.46132723
112PDK10.44976768
113CSNK1D0.44824049
114BCKDK0.43802116
115RPS6KA30.43336691
116ADRBK10.43147040
117PRKCZ0.42939429
118SGK30.42397981
119SRPK10.41364993
120MAP2K10.40246269
121DAPK30.39710956
122ROCK20.39512324
123LIMK10.38850763
124WNK30.38768671
125MAPK120.38502346
126ADRBK20.38344048
127* PRKCA0.37940247
128CDC42BPA0.37019883
129TGFBR10.36436519
130MAP3K60.36040321
131CDK30.36027306
132MAP3K10.35953493
133WNK40.35144223
134RPS6KA50.34843030
135PRKACA0.34071427
136LMTK20.33953976
137CSNK1E0.32405903
138PRKCB0.31913778
139CAMK1G0.31370067
140PLK30.31113948
141PRKACB0.30725237
142FGFR20.27441421
143TLK10.27243512
144PRKCQ0.26143877

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.34812775
2Synaptic vesicle cycle_Homo sapiens_hsa047213.30832359
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.96874130
4Circadian entrainment_Homo sapiens_hsa047132.79371413
5GABAergic synapse_Homo sapiens_hsa047272.79270471
6Long-term potentiation_Homo sapiens_hsa047202.78528213
7Morphine addiction_Homo sapiens_hsa050322.71047808
8* Glutamatergic synapse_Homo sapiens_hsa047242.69162983
9Olfactory transduction_Homo sapiens_hsa047402.64954492
10Amphetamine addiction_Homo sapiens_hsa050312.55127055
11Salivary secretion_Homo sapiens_hsa049702.19010223
12Dopaminergic synapse_Homo sapiens_hsa047282.16740972
13Taste transduction_Homo sapiens_hsa047422.06943240
14Protein export_Homo sapiens_hsa030601.98073128
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97868552
16Butanoate metabolism_Homo sapiens_hsa006501.94371488
17Nitrogen metabolism_Homo sapiens_hsa009101.91880430
18Serotonergic synapse_Homo sapiens_hsa047261.91386395
19Collecting duct acid secretion_Homo sapiens_hsa049661.90858338
20Insulin secretion_Homo sapiens_hsa049111.90337417
21Cholinergic synapse_Homo sapiens_hsa047251.88616845
22Long-term depression_Homo sapiens_hsa047301.83479978
23Renin secretion_Homo sapiens_hsa049241.79828609
24Gastric acid secretion_Homo sapiens_hsa049711.72188818
25Calcium signaling pathway_Homo sapiens_hsa040201.71587469
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71411860
27Oxytocin signaling pathway_Homo sapiens_hsa049211.68396629
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67402593
29Cocaine addiction_Homo sapiens_hsa050301.63353403
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53196076
31Linoleic acid metabolism_Homo sapiens_hsa005911.52636884
32* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39736094
33GnRH signaling pathway_Homo sapiens_hsa049121.38308950
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36870175
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34941268
36Axon guidance_Homo sapiens_hsa043601.33768509
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33634682
38Regulation of autophagy_Homo sapiens_hsa041401.33393354
39Gap junction_Homo sapiens_hsa045401.30290987
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29410345
41Ether lipid metabolism_Homo sapiens_hsa005651.28892991
42cAMP signaling pathway_Homo sapiens_hsa040241.25543002
43Basal transcription factors_Homo sapiens_hsa030221.24004289
44Cardiac muscle contraction_Homo sapiens_hsa042601.18110123
45Vibrio cholerae infection_Homo sapiens_hsa051101.16817776
46Propanoate metabolism_Homo sapiens_hsa006401.14654300
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09584828
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07281804
49Phototransduction_Homo sapiens_hsa047441.06988746
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03941602
51Estrogen signaling pathway_Homo sapiens_hsa049151.03690895
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.02578869
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99464505
54Type II diabetes mellitus_Homo sapiens_hsa049300.99348362
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98909580
56Melanogenesis_Homo sapiens_hsa049160.96270137
57Glioma_Homo sapiens_hsa052140.93914914
58ErbB signaling pathway_Homo sapiens_hsa040120.93704736
59Caffeine metabolism_Homo sapiens_hsa002320.90219393
60Oxidative phosphorylation_Homo sapiens_hsa001900.88874413
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87728363
62Alzheimers disease_Homo sapiens_hsa050100.86558396
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86249372
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85942022
65Pancreatic secretion_Homo sapiens_hsa049720.83805222
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81858219
67ABC transporters_Homo sapiens_hsa020100.81061152
68Tryptophan metabolism_Homo sapiens_hsa003800.79110230
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77264777
70beta-Alanine metabolism_Homo sapiens_hsa004100.77159785
71Oocyte meiosis_Homo sapiens_hsa041140.76756818
72* Phospholipase D signaling pathway_Homo sapiens_hsa040720.75307040
73Peroxisome_Homo sapiens_hsa041460.75040322
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72490045
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70649505
76Dilated cardiomyopathy_Homo sapiens_hsa054140.70595064
77Dorso-ventral axis formation_Homo sapiens_hsa043200.69827036
78Choline metabolism in cancer_Homo sapiens_hsa052310.68759236
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68374481
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67660200
81Chemical carcinogenesis_Homo sapiens_hsa052040.67060578
82MAPK signaling pathway_Homo sapiens_hsa040100.66923165
83RNA polymerase_Homo sapiens_hsa030200.65329913
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.65226842
85Thyroid hormone synthesis_Homo sapiens_hsa049180.64965564
86Fanconi anemia pathway_Homo sapiens_hsa034600.64249773
87RNA degradation_Homo sapiens_hsa030180.62360037
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.62328124
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61747501
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61382141
91Ras signaling pathway_Homo sapiens_hsa040140.58276252
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57469696
93Homologous recombination_Homo sapiens_hsa034400.57305236
94Parkinsons disease_Homo sapiens_hsa050120.54657878
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54195917
96Circadian rhythm_Homo sapiens_hsa047100.54163936
97Retinol metabolism_Homo sapiens_hsa008300.53830713
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.53351084
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52049502
100Selenocompound metabolism_Homo sapiens_hsa004500.50259742
101Steroid biosynthesis_Homo sapiens_hsa001000.49801133
102Rap1 signaling pathway_Homo sapiens_hsa040150.48977211
103Alcoholism_Homo sapiens_hsa050340.48492291
104Sulfur metabolism_Homo sapiens_hsa009200.48154431
105VEGF signaling pathway_Homo sapiens_hsa043700.47684831
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45177560
107Inositol phosphate metabolism_Homo sapiens_hsa005620.45064595
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44103219
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43717239
110Glucagon signaling pathway_Homo sapiens_hsa049220.43652463
111Ovarian steroidogenesis_Homo sapiens_hsa049130.42601814
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42356900
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.42321781
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42227581
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.41514881
116Rheumatoid arthritis_Homo sapiens_hsa053230.40885261
117Huntingtons disease_Homo sapiens_hsa050160.40265285
118African trypanosomiasis_Homo sapiens_hsa051430.39820606
119Wnt signaling pathway_Homo sapiens_hsa043100.39175639
120Prion diseases_Homo sapiens_hsa050200.39046803
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37923405
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37517838
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37474383
124Type I diabetes mellitus_Homo sapiens_hsa049400.37295556
125Metabolic pathways_Homo sapiens_hsa011000.36944451
126Histidine metabolism_Homo sapiens_hsa003400.35854649
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35098412
128Bile secretion_Homo sapiens_hsa049760.34874657
129Renal cell carcinoma_Homo sapiens_hsa052110.34234708
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33926299
131Glycerolipid metabolism_Homo sapiens_hsa005610.33330919
132Purine metabolism_Homo sapiens_hsa002300.33086162
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.31175014
134Endocytosis_Homo sapiens_hsa041440.31114558
135Fatty acid biosynthesis_Homo sapiens_hsa000610.30756334
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30235409
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26262685
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23554223
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23076627
140Chemokine signaling pathway_Homo sapiens_hsa040620.22777155
141Phagosome_Homo sapiens_hsa041450.22120820
142Insulin signaling pathway_Homo sapiens_hsa049100.21528942
143mTOR signaling pathway_Homo sapiens_hsa041500.19720416

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