GRM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar granule cell differentiation (GO:0021707)7.53501316
2response to pheromone (GO:0019236)6.70051084
3locomotory exploration behavior (GO:0035641)6.44128812
4neuronal action potential propagation (GO:0019227)6.17838937
5cerebellar Purkinje cell differentiation (GO:0021702)6.06934637
6gamma-aminobutyric acid transport (GO:0015812)5.97969831
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.92252200
8synaptic vesicle maturation (GO:0016188)5.79384808
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.78835490
10vocalization behavior (GO:0071625)5.74319448
11cellular potassium ion homeostasis (GO:0030007)5.73362717
12sodium ion export (GO:0071436)5.70077941
13regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68983708
14ionotropic glutamate receptor signaling pathway (GO:0035235)5.46705667
15cell differentiation in hindbrain (GO:0021533)5.34588886
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.09247446
17synaptic transmission, glutamatergic (GO:0035249)5.07956378
18positive regulation of synapse maturation (GO:0090129)4.82081349
19synaptic vesicle exocytosis (GO:0016079)4.80547846
20* glutamate receptor signaling pathway (GO:0007215)4.76842667
21* neurotransmitter secretion (GO:0007269)4.75055409
22regulation of synaptic vesicle exocytosis (GO:2000300)4.69687975
23neuromuscular process controlling posture (GO:0050884)4.67357657
24glutamate secretion (GO:0014047)4.51468143
25neuron-neuron synaptic transmission (GO:0007270)4.50411629
26long-term memory (GO:0007616)4.49777704
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.41929725
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.40224241
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.31591827
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.31026471
31L-amino acid import (GO:0043092)4.29297726
32layer formation in cerebral cortex (GO:0021819)4.26061057
33neuromuscular process controlling balance (GO:0050885)4.25355290
34exploration behavior (GO:0035640)4.23694181
35regulation of glutamate receptor signaling pathway (GO:1900449)4.23202324
36positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.22713867
37gamma-aminobutyric acid signaling pathway (GO:0007214)4.19302218
38synaptic vesicle docking involved in exocytosis (GO:0016081)4.10591844
39regulation of synaptic vesicle transport (GO:1902803)4.09345968
40* G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.08958999
41regulation of long-term neuronal synaptic plasticity (GO:0048169)4.07630705
42neurotransmitter-gated ion channel clustering (GO:0072578)4.06815252
43potassium ion import (GO:0010107)4.03133446
44auditory behavior (GO:0031223)3.99787040
45transmission of nerve impulse (GO:0019226)3.99491763
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.97932318
47central nervous system myelination (GO:0022010)3.97536189
48axon ensheathment in central nervous system (GO:0032291)3.97536189
49regulation of synapse structural plasticity (GO:0051823)3.95370084
50cell communication by electrical coupling (GO:0010644)3.92535232
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.92474359
52glycine transport (GO:0015816)3.91434442
53neurotransmitter uptake (GO:0001504)3.89580419
54prepulse inhibition (GO:0060134)3.89534684
55positive regulation of membrane potential (GO:0045838)3.88524410
56membrane depolarization during action potential (GO:0086010)3.88379071
57amino acid import (GO:0043090)3.86656071
58neuronal ion channel clustering (GO:0045161)3.83002950
59adult walking behavior (GO:0007628)3.77012794
60regulation of postsynaptic membrane potential (GO:0060078)3.75989960
61negative regulation of hormone biosynthetic process (GO:0032353)3.73683070
62negative regulation of hormone metabolic process (GO:0032351)3.73683070
63* neurotransmitter transport (GO:0006836)3.72736685
64membrane hyperpolarization (GO:0060081)3.70081705
65protein localization to synapse (GO:0035418)3.69979510
66cellular sodium ion homeostasis (GO:0006883)3.68864520
67dendritic spine morphogenesis (GO:0060997)3.68861398
68regulation of neuronal synaptic plasticity (GO:0048168)3.68434855
69positive regulation of dendritic spine development (GO:0060999)3.68269856
70potassium ion homeostasis (GO:0055075)3.68189529
71regulation of synapse maturation (GO:0090128)3.64137745
72mechanosensory behavior (GO:0007638)3.57762282
73* regulation of neurotransmitter levels (GO:0001505)3.55562535
74establishment of nucleus localization (GO:0040023)3.54103056
75C4-dicarboxylate transport (GO:0015740)3.52370058
76regulation of neurotransmitter secretion (GO:0046928)3.51720252
77membrane depolarization (GO:0051899)3.51087217
78positive regulation of neurotransmitter transport (GO:0051590)3.50941071
79neuron cell-cell adhesion (GO:0007158)3.50720633
80synaptic vesicle endocytosis (GO:0048488)3.48514712
81positive regulation of potassium ion transmembrane transport (GO:1901381)3.42578972
82neuromuscular process (GO:0050905)3.39354848
83dendrite morphogenesis (GO:0048813)3.39297893
84long term synaptic depression (GO:0060292)3.39007835
85cerebellar Purkinje cell layer development (GO:0021680)3.38998540
86regulation of voltage-gated calcium channel activity (GO:1901385)3.35321710
87activation of protein kinase A activity (GO:0034199)3.33765537
88response to auditory stimulus (GO:0010996)3.32082591
89positive regulation of neurotransmitter secretion (GO:0001956)3.30681625
90regulation of neurotransmitter transport (GO:0051588)3.29609729
91positive regulation of dendritic spine morphogenesis (GO:0061003)3.28807597
92cytoskeletal anchoring at plasma membrane (GO:0007016)3.27742509
93regulation of ARF protein signal transduction (GO:0032012)3.26913907
94presynaptic membrane organization (GO:0097090)3.26128627
95vesicle docking involved in exocytosis (GO:0006904)3.25932849
96negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24725402
97cell communication involved in cardiac conduction (GO:0086065)3.24432249
98musculoskeletal movement (GO:0050881)3.23257450
99multicellular organismal movement (GO:0050879)3.23257450
100establishment of synaptic vesicle localization (GO:0097480)3.22357542
101synaptic vesicle transport (GO:0048489)3.22357542
102negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.22269332
103long-term synaptic potentiation (GO:0060291)3.21516598
104* synaptic transmission (GO:0007268)3.20193758
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18783192
106intraspecies interaction between organisms (GO:0051703)3.18232859
107social behavior (GO:0035176)3.18232859
108regulation of calcium ion-dependent exocytosis (GO:0017158)3.17604359
109synapse assembly (GO:0007416)3.16109215
110* signal release (GO:0023061)3.14949228
111neuromuscular synaptic transmission (GO:0007274)3.13845011
112regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.11789441
113chemosensory behavior (GO:0007635)3.11523102
114membrane repolarization (GO:0086009)3.09306572
115* regulation of synaptic transmission (GO:0050804)3.08498741
116regulation of synaptic plasticity (GO:0048167)3.07760383
117regulation of vesicle fusion (GO:0031338)3.03411531
118postsynaptic membrane organization (GO:0001941)3.03322702
119negative regulation of microtubule polymerization (GO:0031115)3.03298320
120regulation of dendritic spine morphogenesis (GO:0061001)3.02859605
121proline transport (GO:0015824)3.01349740
122acidic amino acid transport (GO:0015800)2.95188898
123positive regulation of potassium ion transport (GO:0043268)2.94985243
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94805324
125synapse organization (GO:0050808)2.93213718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.56248881
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.38343223
3IKZF1_21737484_ChIP-ChIP_HCT116_Human3.06928062
4DROSHA_22980978_ChIP-Seq_HELA_Human3.06479121
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98110390
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97979097
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.94044920
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.94044920
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.83809107
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.80494249
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.77758991
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62845660
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61001531
14GBX2_23144817_ChIP-Seq_PC3_Human2.55439988
15* RARB_27405468_Chip-Seq_BRAIN_Mouse2.54049459
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50983016
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48925880
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43062696
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.38779461
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36331358
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.31583519
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.22037296
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.21004927
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17995773
25* EZH2_27304074_Chip-Seq_ESCs_Mouse2.08252667
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.99530880
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94801703
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83625937
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76376181
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72921141
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66358302
32* KDM2B_26808549_Chip-Seq_K562_Human1.56924298
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48964345
34ZNF274_21170338_ChIP-Seq_K562_Hela1.45425477
35* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44743300
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.43512948
37* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42046106
38AR_21572438_ChIP-Seq_LNCaP_Human1.40544353
39* AR_19668381_ChIP-Seq_PC3_Human1.38211270
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38168094
41GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31623267
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31158686
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.27339081
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25631655
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25356513
46STAT3_23295773_ChIP-Seq_U87_Human1.22505858
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22312473
48RNF2_27304074_Chip-Seq_NSC_Mouse1.21197907
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21082723
50* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20736626
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19295127
52* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19157682
53* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17916438
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17622685
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17306436
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15839319
57* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14809395
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14580094
59TP53_16413492_ChIP-PET_HCT116_Human1.09598170
60* TET1_21490601_ChIP-Seq_MESCs_Mouse1.08675932
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08599204
62* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08115995
63* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07374737
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.07259436
65* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06690529
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06453371
67AR_25329375_ChIP-Seq_VCAP_Human1.04747183
68* OCT4_19829295_ChIP-Seq_ESCs_Human1.01431950
69* TCF4_23295773_ChIP-Seq_U87_Human1.01398758
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00930180
71SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00793567
72* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00619327
73* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98779280
74* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98264189
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98052380
76CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97666996
77* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96988205
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96896000
79DPY_21335234_ChIP-Seq_ESCs_Mouse0.96564265
80* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96413829
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95563940
82P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95313255
83RXR_22108803_ChIP-Seq_LS180_Human0.95128052
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94575313
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93837688
86* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93693269
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92331260
88CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92225179
89* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91585549
90* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91090023
91KLF4_19829295_ChIP-Seq_ESCs_Human0.88490178
92* SMAD4_21741376_ChIP-Seq_EPCs_Human0.88370705
93ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86978175
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.86588719
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86316905
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.86073767
97TAF15_26573619_Chip-Seq_HEK293_Human0.85975272
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.83376115
99* SMAD4_21741376_ChIP-Seq_ESCs_Human0.83336520
100RUNX2_22187159_ChIP-Seq_PCA_Human0.82560706
101BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82104025
102* KDM2B_26808549_Chip-Seq_JURKAT_Human0.82000462
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81513075
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.81329868
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80777837
106* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80367441
107* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80367441
108* ARNT_22903824_ChIP-Seq_MCF-7_Human0.80344582
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79791136
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79186061
111* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.78513906
112TP53_20018659_ChIP-ChIP_R1E_Mouse0.77606187
113* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77450708
114P300_19829295_ChIP-Seq_ESCs_Human0.77037788
115CTCF_27219007_Chip-Seq_Bcells_Human0.76872541
116RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76829844
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76742954
118* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76612435
119SMC4_20622854_ChIP-Seq_HELA_Human0.74983165
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74202087
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73097830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.09035688
2MP0009046_muscle_twitch5.11749057
3* MP0003635_abnormal_synaptic_transmissio4.24238339
4MP0008569_lethality_at_weaning3.55112607
5MP0009745_abnormal_behavioral_response3.44627243
6MP0004270_analgesia3.41210870
7MP0002064_seizures3.30410175
8MP0002272_abnormal_nervous_system3.22527313
9MP0003880_abnormal_central_pattern3.18028311
10MP0005423_abnormal_somatic_nervous2.95814080
11* MP0002063_abnormal_learning/memory/cond2.95503278
12MP0002734_abnormal_mechanical_nocicepti2.93838663
13MP0004145_abnormal_muscle_electrophysio2.87368221
14MP0001968_abnormal_touch/_nociception2.87193066
15MP0002572_abnormal_emotion/affect_behav2.73375257
16MP0002067_abnormal_sensory_capabilities2.57689320
17MP0001486_abnormal_startle_reflex2.43869855
18MP0001440_abnormal_grooming_behavior2.41044005
19MP0002184_abnormal_innervation2.38317305
20MP0002736_abnormal_nociception_after2.31483722
21MP0001501_abnormal_sleep_pattern2.30486138
22MP0002735_abnormal_chemical_nociception2.30226552
23MP0002733_abnormal_thermal_nociception2.07164718
24MP0001970_abnormal_pain_threshold1.98950587
25MP0008877_abnormal_DNA_methylation1.95370019
26MP0003123_paternal_imprinting1.93672959
27MP0003329_amyloid_beta_deposits1.93408746
28MP0004142_abnormal_muscle_tone1.86831358
29MP0004924_abnormal_behavior1.86685959
30MP0005386_behavior/neurological_phenoty1.86685959
31MP0004885_abnormal_endolymph1.83482216
32MP0002822_catalepsy1.82066116
33MP0002557_abnormal_social/conspecific_i1.81015578
34MP0003122_maternal_imprinting1.75387905
35MP0003879_abnormal_hair_cell1.74148719
36MP0000955_abnormal_spinal_cord1.69562414
37MP0003632_abnormal_nervous_system1.67496396
38MP0002066_abnormal_motor_capabilities/c1.61539660
39MP0004147_increased_porphyrin_level1.60050358
40MP0004811_abnormal_neuron_physiology1.58737988
41MP0004858_abnormal_nervous_system1.57060545
42MP0002909_abnormal_adrenal_gland1.53134739
43MP0003633_abnormal_nervous_system1.49910320
44MP0004742_abnormal_vestibular_system1.49889799
45MP0000778_abnormal_nervous_system1.48550645
46MP0003631_nervous_system_phenotype1.46173443
47MP0002882_abnormal_neuron_morphology1.37632729
48MP0001348_abnormal_lacrimal_gland1.36037565
49MP0008872_abnormal_physiological_respon1.31741637
50MP0000920_abnormal_myelination1.25360348
51MP0001502_abnormal_circadian_rhythm1.22928317
52MP0003690_abnormal_glial_cell1.20989245
53MP0001984_abnormal_olfaction1.20769036
54MP0002152_abnormal_brain_morphology1.19776402
55MP0009780_abnormal_chondrocyte_physiolo1.13149632
56MP0002229_neurodegeneration1.08075616
57MP0003787_abnormal_imprinting0.98329232
58MP0003283_abnormal_digestive_organ0.96623772
59MP0001905_abnormal_dopamine_level0.94400221
60MP0004043_abnormal_pH_regulation0.94374045
61MP0003137_abnormal_impulse_conducting0.94238260
62MP0005646_abnormal_pituitary_gland0.92735654
63MP0008874_decreased_physiological_sensi0.92561503
64MP0005645_abnormal_hypothalamus_physiol0.92492476
65MP0004215_abnormal_myocardial_fiber0.89832583
66MP0003121_genomic_imprinting0.89236777
67MP0001299_abnormal_eye_distance/0.88397919
68MP0002089_abnormal_postnatal_growth/wei0.87731275
69MP0002069_abnormal_eating/drinking_beha0.87240271
70MP0000569_abnormal_digit_pigmentation0.87091631
71MP0003646_muscle_fatigue0.87022954
72MP0000604_amyloidosis0.83595842
73MP0001177_atelectasis0.83513385
74MP0001485_abnormal_pinna_reflex0.81426826
75MP0004510_myositis0.80936339
76MP0003045_fibrosis0.80317675
77MP0000013_abnormal_adipose_tissue0.79550985
78MP0001963_abnormal_hearing_physiology0.78679642
79MP0004085_abnormal_heartbeat0.77720801
80MP0003634_abnormal_glial_cell0.77615083
81MP0001346_abnormal_lacrimal_gland0.77088613
82MP0006276_abnormal_autonomic_nervous0.76176199
83MP0000751_myopathy0.75164222
84MP0004484_altered_response_of0.72691611
85MP0005083_abnormal_biliary_tract0.72620339
86MP0004233_abnormal_muscle_weight0.72608848
87MP0001986_abnormal_taste_sensitivity0.72272907
88MP0010769_abnormal_survival0.69177313
89MP0005551_abnormal_eye_electrophysiolog0.69125281
90MP0002752_abnormal_somatic_nervous0.68947325
91MP0005167_abnormal_blood-brain_barrier0.67169817
92MP0001188_hyperpigmentation0.66760916
93MP0000631_abnormal_neuroendocrine_gland0.66674215
94MP0005187_abnormal_penis_morphology0.66033855
95MP0010768_mortality/aging0.65793288
96MP0010770_preweaning_lethality0.63477753
97MP0002082_postnatal_lethality0.63477753
98MP0006292_abnormal_olfactory_placode0.63156753
99MP0000579_abnormal_nail_morphology0.62494205
100MP0002638_abnormal_pupillary_reflex0.61516396
101MP0005499_abnormal_olfactory_system0.60145051
102MP0005394_taste/olfaction_phenotype0.60145051
103MP0008961_abnormal_basal_metabolism0.60070902
104MP0010386_abnormal_urinary_bladder0.59957970
105MP0002090_abnormal_vision0.59417195
106MP0006072_abnormal_retinal_apoptosis0.59292163
107MP0003861_abnormal_nervous_system0.59086807
108MP0000747_muscle_weakness0.58683544
109MP0005623_abnormal_meninges_morphology0.58453422
110MP0005535_abnormal_body_temperature0.56198735
111MP0001943_abnormal_respiration0.54117312
112MP0003956_abnormal_body_size0.53860851
113MP0001529_abnormal_vocalization0.53767375
114MP0004133_heterotaxia0.52834706
115MP0001765_abnormal_ion_homeostasis0.52760650
116MP0000639_abnormal_adrenal_gland0.51904394
117MP0009672_abnormal_birth_weight0.51253435
118MP0002653_abnormal_ependyma_morphology0.49259911
119MP0001731_abnormal_postnatal_growth0.49166956
120MP0010234_abnormal_vibrissa_follicle0.48217109

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)7.51288109
2Progressive cerebellar ataxia (HP:0002073)7.30455196
3Focal motor seizures (HP:0011153)6.36071415
4Myokymia (HP:0002411)6.19087968
5Visual hallucinations (HP:0002367)6.09373653
6Gaze-evoked nystagmus (HP:0000640)5.78097897
7Focal seizures (HP:0007359)5.45492496
8Dysmetric saccades (HP:0000641)5.29798555
9Scanning speech (HP:0002168)4.87728078
10Impaired smooth pursuit (HP:0007772)4.73802750
11Dysdiadochokinesis (HP:0002075)4.66661641
12Atonic seizures (HP:0010819)4.59156551
13Hemiplegia (HP:0002301)4.53310492
14Genetic anticipation (HP:0003743)4.45091697
15Cerebral hypomyelination (HP:0006808)4.36699439
16Febrile seizures (HP:0002373)4.32100002
17Abnormality of ocular smooth pursuit (HP:0000617)4.31204205
18Intention tremor (HP:0002080)4.19083456
19Broad-based gait (HP:0002136)4.12631228
20Dysmetria (HP:0001310)4.05978259
21Limb dystonia (HP:0002451)3.83084918
22Epileptic encephalopathy (HP:0200134)3.83063326
23Truncal ataxia (HP:0002078)3.75689037
24Annular pancreas (HP:0001734)3.73651031
25Absence seizures (HP:0002121)3.73409722
26Diplopia (HP:0000651)3.59202759
27Abnormality of binocular vision (HP:0011514)3.59202759
28Abnormality of the lower motor neuron (HP:0002366)3.54528159
29Tetraplegia (HP:0002445)3.52538959
30Hemiparesis (HP:0001269)3.50269473
31Poor eye contact (HP:0000817)3.43762055
32Generalized tonic-clonic seizures (HP:0002069)3.35958301
33Postural tremor (HP:0002174)3.26514769
34Dialeptic seizures (HP:0011146)3.20254301
35Impaired social interactions (HP:0000735)3.16100332
36Abnormal social behavior (HP:0012433)3.16100332
37Depression (HP:0000716)3.13345872
38Ventricular fibrillation (HP:0001663)3.13138668
39Abnormality of saccadic eye movements (HP:0000570)3.12617582
40Status epilepticus (HP:0002133)3.01673695
41Anxiety (HP:0000739)2.96490580
42Limb ataxia (HP:0002070)2.95323960
43Supranuclear gaze palsy (HP:0000605)2.87039195
44Sleep apnea (HP:0010535)2.86235809
45Horizontal nystagmus (HP:0000666)2.81525078
46Abnormal eating behavior (HP:0100738)2.79756628
47Mutism (HP:0002300)2.76375832
48Choreoathetosis (HP:0001266)2.76202249
49Postural instability (HP:0002172)2.68932119
50CNS hypomyelination (HP:0003429)2.68923394
51Impaired vibration sensation in the lower limbs (HP:0002166)2.65834631
52Abnormality of the corticospinal tract (HP:0002492)2.65506829
53Agitation (HP:0000713)2.59227151
54Akinesia (HP:0002304)2.57431814
55Spastic gait (HP:0002064)2.56379794
56Gait ataxia (HP:0002066)2.53377786
57Lower limb asymmetry (HP:0100559)2.50299386
58Amyotrophic lateral sclerosis (HP:0007354)2.49962279
59Bundle branch block (HP:0011710)2.47044245
60Stereotypic behavior (HP:0000733)2.46780961
61Ankle clonus (HP:0011448)2.46731212
62Pointed chin (HP:0000307)2.46616728
63Cerebral inclusion bodies (HP:0100314)2.45027734
64Urinary bladder sphincter dysfunction (HP:0002839)2.44487454
65Increased circulating renin level (HP:0000848)2.38384712
66Morphological abnormality of the pyramidal tract (HP:0002062)2.38061802
67Oligodactyly (hands) (HP:0001180)2.31050293
68Lower limb muscle weakness (HP:0007340)2.24859357
69Myotonia (HP:0002486)2.24255747
70Delusions (HP:0000746)2.20005315
71Rigidity (HP:0002063)2.19729563
72Neuronal loss in central nervous system (HP:0002529)2.18864688
73Spinal canal stenosis (HP:0003416)2.11291409
74Torticollis (HP:0000473)2.10615731
75Fetal akinesia sequence (HP:0001989)2.09995255
76Slow progression (HP:0003677)2.08543006
77Impaired vibratory sensation (HP:0002495)2.08381209
78Incomplete penetrance (HP:0003829)2.05784850
79Clonus (HP:0002169)2.00724187
80Excessive salivation (HP:0003781)2.00630165
81Drooling (HP:0002307)2.00630165
82Apathy (HP:0000741)1.99465853
83Focal dystonia (HP:0004373)1.99317658
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95314091
85Degeneration of the lateral corticospinal tracts (HP:0002314)1.95314091
86Confusion (HP:0001289)1.94035674
87Psychosis (HP:0000709)1.93065023
88Unsteady gait (HP:0002317)1.91816819
89Urinary urgency (HP:0000012)1.89608540
90Bradykinesia (HP:0002067)1.89602036
91Aqueductal stenosis (HP:0002410)1.88641927
92Hand muscle atrophy (HP:0009130)1.88452990
93Megalencephaly (HP:0001355)1.86843090
94Heart block (HP:0012722)1.84051309
95Obstructive sleep apnea (HP:0002870)1.81976719
96Diminished motivation (HP:0000745)1.81070459
97Distal upper limb amyotrophy (HP:0007149)1.80046771
98Upper limb amyotrophy (HP:0009129)1.80046771
99Hyperventilation (HP:0002883)1.79035074
100EEG with generalized epileptiform discharges (HP:0011198)1.78905562
101Rapidly progressive (HP:0003678)1.78603007
102Epileptiform EEG discharges (HP:0011182)1.78078393
103Peripheral hypomyelination (HP:0007182)1.77907718
104Hypoplastic nipples (HP:0002557)1.76465444
105Absent speech (HP:0001344)1.76024000
106Split foot (HP:0001839)1.75863837
107Iris hypopigmentation (HP:0007730)1.75779536
108Shallow orbits (HP:0000586)1.74701590
109Polyphagia (HP:0002591)1.74615845
110Amblyopia (HP:0000646)1.74406861
111Hypsarrhythmia (HP:0002521)1.73467554
112Spastic tetraparesis (HP:0001285)1.72672784
113Nonprogressive disorder (HP:0003680)1.71061692
114Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70550916
115Paraplegia (HP:0010550)1.68840362
116Spastic tetraplegia (HP:0002510)1.68135572
117Papilledema (HP:0001085)1.66957934
118Craniofacial dystonia (HP:0012179)1.65226156
119Progressive inability to walk (HP:0002505)1.64537764
120Insomnia (HP:0100785)1.63361204
121Dysarthria (HP:0001260)1.63339263
122Pheochromocytoma (HP:0002666)1.63014672
123Neurofibrillary tangles (HP:0002185)1.62255561
124Neoplasm of the heart (HP:0100544)1.61489235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK23.98912339
2NTRK33.80877264
3MAP3K93.51249166
4RIPK13.28500083
5MAP3K42.82979515
6CAMKK12.81378551
7MINK12.59008369
8PAK62.52774676
9NTRK22.44625568
10WNK12.29097065
11STK382.26239304
12DAPK22.19811989
13MARK12.14152465
14EPHA41.95581431
15CDK191.95296369
16MAP2K71.93508602
17MAP2K41.93199627
18PRPF4B1.79652000
19FGFR21.77883864
20KSR21.66501868
21RIPK41.52127261
22TYRO31.49416283
23SGK4941.36809775
24SGK2231.36809775
25SGK21.36498316
26NTRK11.35869233
27CDK51.33309419
28PRKCG1.30948609
29ALK1.27583882
30SGK31.27076859
31PRKD31.26254072
32TNIK1.23748778
33KSR11.23165761
34STK111.21708868
35PRKCH1.20333258
36MAPK131.18314525
37GRK51.15155759
38UHMK11.14164014
39TAOK11.13616176
40CAMK11.13055247
41SIK21.11898932
42PNCK1.11760373
43PINK11.09709427
44OXSR11.05680877
45CDK151.05436561
46CDK181.03585622
47CAMK41.00942529
48PLK20.94781241
49CDK11A0.91818485
50RET0.90335149
51CAMK1G0.89006610
52CDK140.86924051
53MAP3K130.85343944
54CDC42BPA0.83254714
55CAMK2G0.82155188
56DAPK10.79928032
57PHKG10.79634977
58PHKG20.79634977
59CAMK2A0.76548655
60MAPKAPK50.76497711
61SGK10.76449405
62WNK40.74935142
63STK390.74333138
64PDK10.73163510
65BMPR20.72598169
66CAMK2B0.72546293
67DYRK1A0.72104185
68NEK60.71420130
69MARK20.71238381
70PKN10.70635410
71FES0.67559846
72LMTK20.67469987
73FRK0.67393019
74PDPK10.67172590
75CASK0.65913921
76MAP3K120.65533590
77RPS6KA30.64712534
78LATS20.63809541
79ARAF0.63484877
80ROCK20.63233520
81LIMK10.61624173
82DAPK30.60984073
83NEK10.56831502
84CAMK2D0.55826502
85MAP3K20.54384048
86FYN0.52400130
87EPHB10.52341849
88PTK20.51007384
89MAP2K60.50935915
90PRKG10.50555739
91MAP3K60.50326571
92PTK60.48265805
93MAPK120.47746864
94TNK20.46538919
95SCYL20.46047551
96BRAF0.45714219
97MAPK100.44159521
98ERBB20.44021917
99PLK30.39884846
100PRKG20.39398828
101RAF10.39076152
102HIPK20.39028147
103MAPK80.38743621
104BRSK10.38574364
105PRKCE0.38108139
106PRKACA0.36056713
107PRKAA10.35729687
108EEF2K0.35653178
109CSNK1G20.35173090
110CSNK1D0.34989880
111PRKCA0.34836818
112PRKDC0.34332804
113PAK30.34236002
114PRKCZ0.33644548
115CSNK1A10.32420579
116PRKACB0.32299911
117TSSK60.32078689
118CSNK1E0.31598866
119RPS6KB10.30229030
120IRAK20.27242201
121GSK3B0.27199360

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.34023213
2* Glutamatergic synapse_Homo sapiens_hsa047242.98270981
3Long-term potentiation_Homo sapiens_hsa047202.97521144
4Synaptic vesicle cycle_Homo sapiens_hsa047212.94414562
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87570773
6Circadian entrainment_Homo sapiens_hsa047132.75908939
7GABAergic synapse_Homo sapiens_hsa047272.75194194
8Morphine addiction_Homo sapiens_hsa050322.48174089
9Long-term depression_Homo sapiens_hsa047302.47682718
10Salivary secretion_Homo sapiens_hsa049702.39347363
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24366853
12Amphetamine addiction_Homo sapiens_hsa050312.23476364
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.15620786
14Olfactory transduction_Homo sapiens_hsa047402.08439171
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.98833723
16Gastric acid secretion_Homo sapiens_hsa049711.98405974
17* Taste transduction_Homo sapiens_hsa047421.94742715
18Dopaminergic synapse_Homo sapiens_hsa047281.93372227
19Insulin secretion_Homo sapiens_hsa049111.82450662
20Cholinergic synapse_Homo sapiens_hsa047251.80330457
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71788917
22Vitamin B6 metabolism_Homo sapiens_hsa007501.71493355
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65586364
24Calcium signaling pathway_Homo sapiens_hsa040201.58836325
25Type II diabetes mellitus_Homo sapiens_hsa049301.58430630
26Oxytocin signaling pathway_Homo sapiens_hsa049211.57442992
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.54961475
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43291923
29GnRH signaling pathway_Homo sapiens_hsa049121.41058832
30cAMP signaling pathway_Homo sapiens_hsa040241.40450578
31Cocaine addiction_Homo sapiens_hsa050301.37981918
32Serotonergic synapse_Homo sapiens_hsa047261.35541486
33Renin secretion_Homo sapiens_hsa049241.34352284
34Gap junction_Homo sapiens_hsa045401.32988763
35Pancreatic secretion_Homo sapiens_hsa049721.31837329
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28157856
37Estrogen signaling pathway_Homo sapiens_hsa049151.27865255
38Thyroid hormone synthesis_Homo sapiens_hsa049181.17006018
39Nitrogen metabolism_Homo sapiens_hsa009101.16638913
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08202150
41Phototransduction_Homo sapiens_hsa047441.06158480
42Oocyte meiosis_Homo sapiens_hsa041141.01386783
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00030092
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98411842
45Cardiac muscle contraction_Homo sapiens_hsa042600.97326675
46Bile secretion_Homo sapiens_hsa049760.93534874
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89204845
48* Phospholipase D signaling pathway_Homo sapiens_hsa040720.88117284
49Melanogenesis_Homo sapiens_hsa049160.85114582
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84616610
51Inositol phosphate metabolism_Homo sapiens_hsa005620.83777309
52Vibrio cholerae infection_Homo sapiens_hsa051100.82377721
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.82030342
54Glioma_Homo sapiens_hsa052140.79538425
55Dilated cardiomyopathy_Homo sapiens_hsa054140.79300415
56Dorso-ventral axis formation_Homo sapiens_hsa043200.78082071
57ErbB signaling pathway_Homo sapiens_hsa040120.77773379
58Choline metabolism in cancer_Homo sapiens_hsa052310.75605551
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72522866
60MAPK signaling pathway_Homo sapiens_hsa040100.72487985
61Axon guidance_Homo sapiens_hsa043600.71625994
62Arginine and proline metabolism_Homo sapiens_hsa003300.69273552
63* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68832481
64Circadian rhythm_Homo sapiens_hsa047100.67846028
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66458784
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62204326
67mTOR signaling pathway_Homo sapiens_hsa041500.59857098
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.57951365
69Collecting duct acid secretion_Homo sapiens_hsa049660.54806551
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54550853
71Ovarian steroidogenesis_Homo sapiens_hsa049130.54328780
72VEGF signaling pathway_Homo sapiens_hsa043700.50175064
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49834373
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49391670
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49246096
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49087292
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48031874
78Alzheimers disease_Homo sapiens_hsa050100.47621604
79Rap1 signaling pathway_Homo sapiens_hsa040150.46492353
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.44641170
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.43161665
82Mineral absorption_Homo sapiens_hsa049780.42923933
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42707150
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42594472
85Endocytosis_Homo sapiens_hsa041440.42091691
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40730074
87Glucagon signaling pathway_Homo sapiens_hsa049220.40406655
88beta-Alanine metabolism_Homo sapiens_hsa004100.38976846
89Endometrial cancer_Homo sapiens_hsa052130.38946885
90Non-small cell lung cancer_Homo sapiens_hsa052230.38809493
91Tight junction_Homo sapiens_hsa045300.36778388
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36134481
93Alcoholism_Homo sapiens_hsa050340.35037039
94Ras signaling pathway_Homo sapiens_hsa040140.34965825
95Chemokine signaling pathway_Homo sapiens_hsa040620.34791382
96Ether lipid metabolism_Homo sapiens_hsa005650.33764184
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33728953
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.32931514
99Histidine metabolism_Homo sapiens_hsa003400.32496929
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31988491
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31566656
102AMPK signaling pathway_Homo sapiens_hsa041520.31296934
103Arginine biosynthesis_Homo sapiens_hsa002200.31041889
104Platelet activation_Homo sapiens_hsa046110.30823620
105Renal cell carcinoma_Homo sapiens_hsa052110.28783703
106Prion diseases_Homo sapiens_hsa050200.28717952
107Proteoglycans in cancer_Homo sapiens_hsa052050.27110794
108Hedgehog signaling pathway_Homo sapiens_hsa043400.26912372
109Wnt signaling pathway_Homo sapiens_hsa043100.26123203
110Butanoate metabolism_Homo sapiens_hsa006500.24392678
111Hippo signaling pathway_Homo sapiens_hsa043900.22494842
112Insulin signaling pathway_Homo sapiens_hsa049100.22352537
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21665448
114Fatty acid biosynthesis_Homo sapiens_hsa000610.21134604
115ABC transporters_Homo sapiens_hsa020100.21009499
116Prolactin signaling pathway_Homo sapiens_hsa049170.20800011
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19781140
118Oxidative phosphorylation_Homo sapiens_hsa001900.19599526
119Regulation of autophagy_Homo sapiens_hsa041400.18255181
120Protein digestion and absorption_Homo sapiens_hsa049740.17936292

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