GRK7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.76865776
2behavioral response to nicotine (GO:0035095)4.55703564
3nucleotide transmembrane transport (GO:1901679)4.26101766
4cell wall macromolecule metabolic process (GO:0044036)4.11776978
5water-soluble vitamin biosynthetic process (GO:0042364)3.97371070
6response to pheromone (GO:0019236)3.91575866
7piRNA metabolic process (GO:0034587)3.90330854
8fucose catabolic process (GO:0019317)3.88099751
9L-fucose metabolic process (GO:0042354)3.88099751
10L-fucose catabolic process (GO:0042355)3.88099751
11cell wall macromolecule catabolic process (GO:0016998)3.83138883
12protein neddylation (GO:0045116)3.81030542
13tryptophan catabolic process (GO:0006569)3.73963680
14indole-containing compound catabolic process (GO:0042436)3.73963680
15indolalkylamine catabolic process (GO:0046218)3.73963680
16organic cation transport (GO:0015695)3.72927841
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.65512663
18inositol phosphate catabolic process (GO:0071545)3.61615644
19respiratory chain complex IV assembly (GO:0008535)3.58828319
20nucleoside transmembrane transport (GO:1901642)3.49902372
21detection of light stimulus involved in sensory perception (GO:0050962)3.46575261
22detection of light stimulus involved in visual perception (GO:0050908)3.46575261
23negative regulation of mast cell activation (GO:0033004)3.45464241
24indolalkylamine metabolic process (GO:0006586)3.44740173
25phosphorylated carbohydrate dephosphorylation (GO:0046838)3.43724040
26inositol phosphate dephosphorylation (GO:0046855)3.43724040
27heme transport (GO:0015886)3.43205798
28negative regulation of telomere maintenance (GO:0032205)3.42544377
29axoneme assembly (GO:0035082)3.39340184
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.35034528
31kynurenine metabolic process (GO:0070189)3.34536555
32tryptophan metabolic process (GO:0006568)3.32187538
33platelet dense granule organization (GO:0060155)3.31739852
34phosphatidylinositol acyl-chain remodeling (GO:0036149)3.19303700
35regulation of cilium movement (GO:0003352)3.17801803
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.16303186
37NADH dehydrogenase complex assembly (GO:0010257)3.16303186
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16303186
39cilium morphogenesis (GO:0060271)3.11959351
40protein localization to cilium (GO:0061512)3.09063238
41polyol catabolic process (GO:0046174)3.07052231
42cytochrome complex assembly (GO:0017004)3.06696393
43phosphatidylcholine acyl-chain remodeling (GO:0036151)3.06077204
44epithelial cilium movement (GO:0003351)3.05111920
45phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.04091487
46DNA methylation involved in gamete generation (GO:0043046)3.03138385
47protein complex biogenesis (GO:0070271)3.00910456
48cofactor transport (GO:0051181)2.97094011
49regulation of nuclear cell cycle DNA replication (GO:0033262)2.95212029
50male meiosis I (GO:0007141)2.94247567
51protein deneddylation (GO:0000338)2.92474384
52protein K6-linked ubiquitination (GO:0085020)2.91790839
53positive regulation of mitochondrial fission (GO:0090141)2.90899024
54cullin deneddylation (GO:0010388)2.89249405
55synapsis (GO:0007129)2.84892423
56neural tube formation (GO:0001841)2.82394407
57pyrimidine nucleobase catabolic process (GO:0006208)2.82033766
58preassembly of GPI anchor in ER membrane (GO:0016254)2.80539020
59cornea development in camera-type eye (GO:0061303)2.80262137
60cellular biogenic amine catabolic process (GO:0042402)2.79676157
61amine catabolic process (GO:0009310)2.79676157
62phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.79111240
63purine ribonucleotide transport (GO:0015868)2.78882622
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77480677
65photoreceptor cell maintenance (GO:0045494)2.76174336
66RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76062207
67regulation of meiosis I (GO:0060631)2.74624668
68dopamine transport (GO:0015872)2.72975338
69glycerophospholipid catabolic process (GO:0046475)2.72538460
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70957293
71regulation of isotype switching to IgG isotypes (GO:0048302)2.70013124
72replication fork processing (GO:0031297)2.69861064
73adaptation of signaling pathway (GO:0023058)2.69381733
74phosphatidylserine acyl-chain remodeling (GO:0036150)2.69066840
75mitochondrial respiratory chain complex assembly (GO:0033108)2.64156282
76multicellular organism reproduction (GO:0032504)2.59773530
77oxidative demethylation (GO:0070989)2.57621370
78auditory receptor cell stereocilium organization (GO:0060088)2.56263726
79protein polyglutamylation (GO:0018095)2.56041595
80DNA double-strand break processing (GO:0000729)2.55613884
81iron coordination entity transport (GO:1901678)2.53787554
82negative regulation of DNA-dependent DNA replication (GO:2000104)2.53257367
83regulation of hexokinase activity (GO:1903299)2.53147706
84regulation of glucokinase activity (GO:0033131)2.53147706
85reciprocal DNA recombination (GO:0035825)2.51378824
86reciprocal meiotic recombination (GO:0007131)2.51378824
87photoreceptor cell development (GO:0042461)2.51256347
88aspartate family amino acid catabolic process (GO:0009068)2.50997004
89telomere maintenance via telomerase (GO:0007004)2.50067846
90behavioral response to ethanol (GO:0048149)2.49951927
91mannosylation (GO:0097502)2.49732977
92inner ear receptor stereocilium organization (GO:0060122)2.49398509
93regulation of telomere maintenance (GO:0032204)2.49392850
94regulation of rhodopsin mediated signaling pathway (GO:0022400)2.48175180
95positive regulation of fatty acid transport (GO:2000193)2.47883514
96nucleobase catabolic process (GO:0046113)2.47688268
97positive regulation of T-helper 1 type immune response (GO:0002827)2.47593047
98negative regulation of systemic arterial blood pressure (GO:0003085)2.47109325
99cytidine deamination (GO:0009972)2.45160086
100cytidine catabolic process (GO:0006216)2.45160086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.82116693
2VDR_22108803_ChIP-Seq_LS180_Human3.47557804
3IGF1R_20145208_ChIP-Seq_DFB_Human2.96295221
4GBX2_23144817_ChIP-Seq_PC3_Human2.70897825
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.49736984
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47975476
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46986786
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42663842
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39617633
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37830725
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34349424
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.20833530
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13753472
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.06369927
15FUS_26573619_Chip-Seq_HEK293_Human2.06256613
16EWS_26573619_Chip-Seq_HEK293_Human2.03137440
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97682475
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97638269
19TAF15_26573619_Chip-Seq_HEK293_Human1.95154460
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95111575
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.94658945
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.91935424
23P300_19829295_ChIP-Seq_ESCs_Human1.89114543
24ER_23166858_ChIP-Seq_MCF-7_Human1.88665854
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88042614
26TP53_22573176_ChIP-Seq_HFKS_Human1.75591457
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74889037
28EZH2_22144423_ChIP-Seq_EOC_Human1.69474651
29VDR_23849224_ChIP-Seq_CD4+_Human1.66742448
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65224515
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61089174
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58485760
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57509078
34CBP_20019798_ChIP-Seq_JUKART_Human1.52217785
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52217785
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50822484
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49804336
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48993666
39ELK1_19687146_ChIP-ChIP_HELA_Human1.46698226
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46487853
41IRF1_19129219_ChIP-ChIP_H3396_Human1.45752457
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45392754
43STAT3_23295773_ChIP-Seq_U87_Human1.43773205
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43199229
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.43161125
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43161125
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42325744
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.41159305
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.40572038
50BCAT_22108803_ChIP-Seq_LS180_Human1.40278604
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40135687
52TCF4_22108803_ChIP-Seq_LS180_Human1.38463583
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.36825492
54* SOX2_19829295_ChIP-Seq_ESCs_Human1.35565687
55* NANOG_19829295_ChIP-Seq_ESCs_Human1.35565687
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34645972
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34613579
58* TCF4_23295773_ChIP-Seq_U87_Human1.34233754
59SMAD4_21799915_ChIP-Seq_A2780_Human1.33491266
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32196943
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32090531
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.31479958
63AR_20517297_ChIP-Seq_VCAP_Human1.30994977
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29498608
65NCOR_22424771_ChIP-Seq_293T_Human1.28970250
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28274806
67MYC_18940864_ChIP-ChIP_HL60_Human1.27194592
68AR_25329375_ChIP-Seq_VCAP_Human1.25216917
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.20180614
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.19524759
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18855028
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.17340624
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.14514138
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13197945
75RUNX2_22187159_ChIP-Seq_PCA_Human1.12634663
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.12335309
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12317054
78CDX2_22108803_ChIP-Seq_LS180_Human1.11609347
79HOXB7_26014856_ChIP-Seq_BT474_Human1.11525678
80FOXH1_21741376_ChIP-Seq_EPCs_Human1.10938779
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10839820
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.10633559
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.09927252
84P53_22387025_ChIP-Seq_ESCs_Mouse1.09272585
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08789067
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08144498
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07855885
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.07222671
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07022313
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.05841476
91REST_21632747_ChIP-Seq_MESCs_Mouse1.05761229
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04614934
93FOXP3_21729870_ChIP-Seq_TREG_Human1.04120801
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03864606
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.03838988
96EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02124359
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01242156
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01050999
99MYC_19829295_ChIP-Seq_ESCs_Human0.97478173
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97326679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.18496628
2MP0005551_abnormal_eye_electrophysiolog2.80717058
3MP0003195_calcinosis2.59629861
4MP0003011_delayed_dark_adaptation2.54322333
5MP0001968_abnormal_touch/_nociception2.51468023
6MP0002837_dystrophic_cardiac_calcinosis2.48701982
7MP0003787_abnormal_imprinting2.48634010
8MP0001986_abnormal_taste_sensitivity2.44620659
9MP0000372_irregular_coat_pigmentation2.24610979
10MP0003880_abnormal_central_pattern2.20393395
11MP0002736_abnormal_nociception_after2.09944985
12MP0002653_abnormal_ependyma_morphology2.07921022
13MP0008872_abnormal_physiological_respon2.03277537
14MP0001984_abnormal_olfaction2.02140729
15MP0002102_abnormal_ear_morphology1.99872029
16MP0005646_abnormal_pituitary_gland1.96000669
17MP0005084_abnormal_gallbladder_morpholo1.92011388
18MP0008875_abnormal_xenobiotic_pharmacok1.90794932
19MP0004782_abnormal_surfactant_physiolog1.87561269
20MP0002876_abnormal_thyroid_physiology1.82241440
21MP0006072_abnormal_retinal_apoptosis1.79419755
22MP0006276_abnormal_autonomic_nervous1.77909898
23MP0005253_abnormal_eye_physiology1.76973653
24MP0004147_increased_porphyrin_level1.76717861
25MP0009745_abnormal_behavioral_response1.66664069
26MP0002735_abnormal_chemical_nociception1.66533442
27MP0003646_muscle_fatigue1.56141325
28MP0009046_muscle_twitch1.52158467
29MP0005167_abnormal_blood-brain_barrier1.51621578
30MP0000569_abnormal_digit_pigmentation1.48443330
31MP0002163_abnormal_gland_morphology1.48316570
32MP0001486_abnormal_startle_reflex1.45009705
33MP0005410_abnormal_fertilization1.44851559
34MP0001529_abnormal_vocalization1.40771649
35MP0005389_reproductive_system_phenotype1.39210570
36MP0008058_abnormal_DNA_repair1.38888494
37MP0002160_abnormal_reproductive_system1.38767093
38MP0005075_abnormal_melanosome_morpholog1.38630305
39MP0000427_abnormal_hair_cycle1.38283512
40MP0003718_maternal_effect1.37365966
41MP0002638_abnormal_pupillary_reflex1.37020294
42MP0008789_abnormal_olfactory_epithelium1.35182543
43MP0006292_abnormal_olfactory_placode1.35150658
44MP0004133_heterotaxia1.34512770
45MP0005499_abnormal_olfactory_system1.30021241
46MP0005394_taste/olfaction_phenotype1.30021241
47MP0002272_abnormal_nervous_system1.29125901
48MP0001501_abnormal_sleep_pattern1.26733992
49MP0005645_abnormal_hypothalamus_physiol1.25611371
50MP0002938_white_spotting1.23345767
51MP0001485_abnormal_pinna_reflex1.23295818
52MP0004142_abnormal_muscle_tone1.22963845
53MP0004924_abnormal_behavior1.22004421
54MP0005386_behavior/neurological_phenoty1.22004421
55MP0001919_abnormal_reproductive_system1.18773415
56MP0002234_abnormal_pharynx_morphology1.16269349
57MP0005379_endocrine/exocrine_gland_phen1.15043720
58MP0005174_abnormal_tail_pigmentation1.14000653
59MP0003137_abnormal_impulse_conducting1.12945568
60MP0004885_abnormal_endolymph1.11741972
61MP0004043_abnormal_pH_regulation1.11667036
62MP0002928_abnormal_bile_duct1.11081351
63MP0000631_abnormal_neuroendocrine_gland1.10677117
64MP0001970_abnormal_pain_threshold1.10275922
65MP0001293_anophthalmia1.09335709
66MP0002733_abnormal_thermal_nociception1.08153050
67MP0002572_abnormal_emotion/affect_behav1.05954260
68MP0002734_abnormal_mechanical_nocicepti1.03017561
69MP0001177_atelectasis1.00523917
70MP0004215_abnormal_myocardial_fiber0.99766462
71MP0006035_abnormal_mitochondrial_morpho0.98327272
72MP0004145_abnormal_muscle_electrophysio0.98298024
73MP0002751_abnormal_autonomic_nervous0.96959849
74MP0006036_abnormal_mitochondrial_physio0.95610760
75MP0002064_seizures0.93883133
76MP0003786_premature_aging0.93259642
77MP0001929_abnormal_gametogenesis0.93201781
78MP0002557_abnormal_social/conspecific_i0.92688590
79MP0008775_abnormal_heart_ventricle0.92609532
80MP0003136_yellow_coat_color0.92307704
81MP0001440_abnormal_grooming_behavior0.91958621
82MP0001905_abnormal_dopamine_level0.90289754
83MP0005195_abnormal_posterior_eye0.88854874
84MP0005171_absent_coat_pigmentation0.88781001
85MP0004742_abnormal_vestibular_system0.87055769
86MP0002332_abnormal_exercise_endurance0.85597726
87MP0003698_abnormal_male_reproductive0.85390321
88MP0005671_abnormal_response_to0.85366793
89MP0005423_abnormal_somatic_nervous0.83294276
90MP0002067_abnormal_sensory_capabilities0.81817457
91MP0000383_abnormal_hair_follicle0.80660585
92MP0005085_abnormal_gallbladder_physiolo0.80459098
93MP0008995_early_reproductive_senescence0.80326006
94MP0002229_neurodegeneration0.79725018
95MP0003890_abnormal_embryonic-extraembry0.79083321
96MP0005365_abnormal_bile_salt0.78900016
97MP0009764_decreased_sensitivity_to0.77343680
98MP0003567_abnormal_fetal_cardiomyocyte0.76322015
99MP0002095_abnormal_skin_pigmentation0.74026248
100MP0003121_genomic_imprinting0.73859966

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.51624654
2Pancreatic fibrosis (HP:0100732)4.05018545
3True hermaphroditism (HP:0010459)3.90464917
4Abnormality of midbrain morphology (HP:0002418)3.89975347
5Molar tooth sign on MRI (HP:0002419)3.89975347
6Abnormality of the renal cortex (HP:0011035)3.51474661
7Chronic hepatic failure (HP:0100626)3.41455564
8Nephronophthisis (HP:0000090)3.25911567
9Congenital stationary night blindness (HP:0007642)3.20778126
10Abnormality of the renal medulla (HP:0100957)3.13867377
11Type II lissencephaly (HP:0007260)3.01351764
12Pendular nystagmus (HP:0012043)2.96832862
13Medial flaring of the eyebrow (HP:0010747)2.94724263
14Abolished electroretinogram (ERG) (HP:0000550)2.88013749
15Progressive inability to walk (HP:0002505)2.85703949
16Cystic liver disease (HP:0006706)2.80154940
17Renal cortical cysts (HP:0000803)2.79208922
18Large for gestational age (HP:0001520)2.65796794
19Attenuation of retinal blood vessels (HP:0007843)2.64699264
20Inability to walk (HP:0002540)2.60320926
21Progressive macrocephaly (HP:0004481)2.58935332
22Acute necrotizing encephalopathy (HP:0006965)2.58895330
23Stomach cancer (HP:0012126)2.56275265
24Sclerocornea (HP:0000647)2.51398031
25Increased corneal curvature (HP:0100692)2.50442109
26Keratoconus (HP:0000563)2.50442109
27Tubular atrophy (HP:0000092)2.48020055
28Stomatitis (HP:0010280)2.46108009
29Broad-based gait (HP:0002136)2.45891180
30Hypothermia (HP:0002045)2.44927199
31Lissencephaly (HP:0001339)2.44285513
32Absent/shortened dynein arms (HP:0200106)2.43108637
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.43108637
34Abnormality of the labia minora (HP:0012880)2.38731260
35Congenital hepatic fibrosis (HP:0002612)2.37284712
36Abnormal drinking behavior (HP:0030082)2.32550547
37Polydipsia (HP:0001959)2.32550547
38Decreased central vision (HP:0007663)2.30818859
39Gaze-evoked nystagmus (HP:0000640)2.25765102
40Mitochondrial inheritance (HP:0001427)2.25442641
41Acute encephalopathy (HP:0006846)2.24757829
42Abnormal rod and cone electroretinograms (HP:0008323)2.24146897
43Bile duct proliferation (HP:0001408)2.23311906
44Abnormal biliary tract physiology (HP:0012439)2.23311906
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21978126
46Retinal dysplasia (HP:0007973)2.21876097
47Aplasia/Hypoplasia of the tongue (HP:0010295)2.21297616
48Aplasia/hypoplasia of the uterus (HP:0008684)2.21095321
49Increased CSF lactate (HP:0002490)2.20466755
50Gait imbalance (HP:0002141)2.19038351
51Hypoplasia of the uterus (HP:0000013)2.18497939
52Hypoproteinemia (HP:0003075)2.17678366
53Congenital primary aphakia (HP:0007707)2.16185481
543-Methylglutaconic aciduria (HP:0003535)2.14353471
55Dyskinesia (HP:0100660)2.13260382
56Widely spaced teeth (HP:0000687)2.11631801
57Hyperventilation (HP:0002883)2.10836549
58Protruding tongue (HP:0010808)2.08029302
59Nephrogenic diabetes insipidus (HP:0009806)2.06926082
60Male pseudohermaphroditism (HP:0000037)2.05104124
61Hypoalbuminemia (HP:0003073)2.04653355
62Abnormal albumin level (HP:0012116)2.04653355
63Hypomagnesemia (HP:0002917)2.03956599
64Lipid accumulation in hepatocytes (HP:0006561)2.03561104
65Increased hepatocellular lipid droplets (HP:0006565)2.02734631
66Anencephaly (HP:0002323)2.01393427
67Optic disc pallor (HP:0000543)2.01254183
68Abnormal mitochondria in muscle tissue (HP:0008316)2.01202877
69Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99725384
70Fair hair (HP:0002286)1.97537511
71Bony spicule pigmentary retinopathy (HP:0007737)1.95179706
72Febrile seizures (HP:0002373)1.92743528
73Abnormality of macular pigmentation (HP:0008002)1.92676145
74Abnormal respiratory epithelium morphology (HP:0012253)1.92577051
75Abnormal respiratory motile cilium morphology (HP:0005938)1.92577051
76Cerebellar dysplasia (HP:0007033)1.91323820
77Small hand (HP:0200055)1.88161680
78Clumsiness (HP:0002312)1.87527842
79Genital tract atresia (HP:0001827)1.86923739
80Focal motor seizures (HP:0011153)1.84978658
81Volvulus (HP:0002580)1.84380613
82Tubulointerstitial nephritis (HP:0001970)1.83310402
83Furrowed tongue (HP:0000221)1.83107425
84Polyuria (HP:0000103)1.82926653
85Methylmalonic acidemia (HP:0002912)1.80886406
86Generalized hypopigmentation of hair (HP:0011358)1.79479928
87Vaginal atresia (HP:0000148)1.79471796
88Hyperglycinuria (HP:0003108)1.79078331
89Agitation (HP:0000713)1.76879823
90Methylmalonic aciduria (HP:0012120)1.76725891
91Oligodactyly (hands) (HP:0001180)1.76405106
92Postaxial hand polydactyly (HP:0001162)1.76171536
93IgG deficiency (HP:0004315)1.75455979
94Occipital encephalocele (HP:0002085)1.75036205
95Postaxial foot polydactyly (HP:0001830)1.74354364
96Abnormality of the pons (HP:0007361)1.73113237
97Patellar aplasia (HP:0006443)1.72165183
98Increased serum lactate (HP:0002151)1.70617537
99Abnormality of eosinophils (HP:0001879)1.70019224
100Aplasia/Hypoplasia of the patella (HP:0006498)1.69845788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.18439846
2MAP4K22.95779662
3MST42.62020061
4TNIK2.61002888
5TXK2.55764368
6BMPR1B2.50810008
7WNK32.42587658
8TAOK32.40757001
9WNK42.30693966
10INSRR2.25124759
11ADRBK22.14318757
12ZAK2.05725212
13NUAK12.00716353
14GRK11.98498378
15TRIM281.95500683
16TLK11.92465152
17TIE11.91372889
18ACVR1B1.87559115
19MAPK131.85814675
20STK391.82664148
21EIF2AK31.79163962
22MAP3K41.64104666
23OXSR11.52823574
24FGFR21.47586906
25BCR1.42982741
26DAPK21.29537426
27PAK31.27315930
28PLK21.24997926
29PIK3CA1.22908387
30PINK11.16821287
31ERBB31.16718259
32TSSK61.16257956
33MAP2K71.09683499
34PLK41.08439320
35TEC1.05703173
36PLK31.04899629
37CSNK1G31.04209631
38EPHA41.02995512
39CASK1.02513430
40CSNK1G21.00853794
41ADRBK10.99434838
42VRK20.99329529
43STK38L0.98948893
44CSNK1G10.95572913
45VRK10.94924433
46MKNK20.94162984
47BCKDK0.91826758
48DYRK30.89316305
49PRKCE0.88058246
50EIF2AK10.87115122
51MARK10.85787209
52CSNK1A1L0.80863942
53IKBKB0.79222041
54DYRK20.75181809
55PHKG20.73366163
56PHKG10.73366163
57FER0.70406814
58TNK20.68241147
59EPHA30.67084633
60STK30.66992197
61IRAK10.64482090
62PRKCG0.60784166
63GRK50.60648439
64NLK0.60061936
65CAMKK20.59529207
66CSNK1A10.58716391
67MAPKAPK30.57871932
68GRK70.53376180
69CDK190.52672533
70PTK2B0.52498729
71CAMK2A0.51791272
72SRPK10.50372501
73EIF2AK20.49791641
74PRKCQ0.47698793
75PLK10.47412833
76PRKCI0.45825795
77ITK0.45549881
78MAPK150.45519250
79RPS6KA50.45162863
80BMPR20.43013536
81BRSK20.42201179
82MUSK0.40968580
83CSNK1D0.40356215
84FGFR10.38877540
85MAPKAPK50.38311743
86MINK10.38016036
87KIT0.37982419
88TGFBR10.36416898
89TGFBR20.35712173
90ABL10.35686492
91* PRKACA0.35672293
92NEK20.34149595
93STK110.33288442
94ATM0.31742923
95ATR0.31442817
96MKNK10.29962192
97IGF1R0.28928944
98CSF1R0.28555794
99CHUK0.27206892
100DYRK1A0.26951067

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.45616377
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.26512430
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.05002290
4Linoleic acid metabolism_Homo sapiens_hsa005913.01110686
5* Phototransduction_Homo sapiens_hsa047442.89456540
6Ether lipid metabolism_Homo sapiens_hsa005652.58149670
7Protein export_Homo sapiens_hsa030602.35815299
8Nitrogen metabolism_Homo sapiens_hsa009102.30535418
9Caffeine metabolism_Homo sapiens_hsa002322.25493210
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09883984
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09066154
12Oxidative phosphorylation_Homo sapiens_hsa001901.99020561
13Selenocompound metabolism_Homo sapiens_hsa004501.98662434
14Proteasome_Homo sapiens_hsa030501.81993107
15RNA polymerase_Homo sapiens_hsa030201.80356706
16Basal transcription factors_Homo sapiens_hsa030221.65891269
17One carbon pool by folate_Homo sapiens_hsa006701.61994364
18Tryptophan metabolism_Homo sapiens_hsa003801.55617645
19Nicotine addiction_Homo sapiens_hsa050331.55206387
20RNA degradation_Homo sapiens_hsa030181.53311121
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52109548
22Asthma_Homo sapiens_hsa053101.47864697
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.45317852
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44410807
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42786257
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.42521631
27Propanoate metabolism_Homo sapiens_hsa006401.38510238
28Butanoate metabolism_Homo sapiens_hsa006501.32167740
29Peroxisome_Homo sapiens_hsa041461.32106920
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31107379
31Parkinsons disease_Homo sapiens_hsa050121.30001009
32Regulation of autophagy_Homo sapiens_hsa041401.29895050
33Fanconi anemia pathway_Homo sapiens_hsa034601.29391919
34Arachidonic acid metabolism_Homo sapiens_hsa005901.29165184
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24758451
36Olfactory transduction_Homo sapiens_hsa047401.24478492
37Allograft rejection_Homo sapiens_hsa053301.23167530
38Homologous recombination_Homo sapiens_hsa034401.16622629
39Autoimmune thyroid disease_Homo sapiens_hsa053201.14973625
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13300582
41Graft-versus-host disease_Homo sapiens_hsa053321.10967036
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08517658
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04078454
44Type I diabetes mellitus_Homo sapiens_hsa049401.00143834
45Retinol metabolism_Homo sapiens_hsa008301.00115173
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.97573007
47Fat digestion and absorption_Homo sapiens_hsa049750.95779295
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.95371774
49Chemical carcinogenesis_Homo sapiens_hsa052040.95129548
50Folate biosynthesis_Homo sapiens_hsa007900.90806095
51Collecting duct acid secretion_Homo sapiens_hsa049660.90610548
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87694099
53Morphine addiction_Homo sapiens_hsa050320.84387280
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83882590
55Non-homologous end-joining_Homo sapiens_hsa034500.83198644
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81222842
57Glycerolipid metabolism_Homo sapiens_hsa005610.80955865
58Huntingtons disease_Homo sapiens_hsa050160.79989904
59Taste transduction_Homo sapiens_hsa047420.79246290
60ABC transporters_Homo sapiens_hsa020100.79216923
61Steroid biosynthesis_Homo sapiens_hsa001000.75574272
62Alzheimers disease_Homo sapiens_hsa050100.74098282
63Sulfur metabolism_Homo sapiens_hsa009200.72304271
64Primary immunodeficiency_Homo sapiens_hsa053400.71030600
65Serotonergic synapse_Homo sapiens_hsa047260.69289816
66Pyrimidine metabolism_Homo sapiens_hsa002400.69212410
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68946710
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67700749
69Rheumatoid arthritis_Homo sapiens_hsa053230.67254389
70GABAergic synapse_Homo sapiens_hsa047270.66480825
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66345949
72Dorso-ventral axis formation_Homo sapiens_hsa043200.65486767
73Purine metabolism_Homo sapiens_hsa002300.65187108
74Metabolic pathways_Homo sapiens_hsa011000.63243384
75Sulfur relay system_Homo sapiens_hsa041220.63172097
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62505676
77Mineral absorption_Homo sapiens_hsa049780.61354627
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60633912
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.59130501
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58780265
81Vitamin digestion and absorption_Homo sapiens_hsa049770.57832281
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57746790
83Ovarian steroidogenesis_Homo sapiens_hsa049130.56439026
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54772442
85Insulin secretion_Homo sapiens_hsa049110.53600776
86beta-Alanine metabolism_Homo sapiens_hsa004100.51393946
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48593995
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47767781
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46830982
90Cardiac muscle contraction_Homo sapiens_hsa042600.46314476
91Glutamatergic synapse_Homo sapiens_hsa047240.46098003
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45126480
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44470266
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.43838121
95Circadian rhythm_Homo sapiens_hsa047100.38673372
96Circadian entrainment_Homo sapiens_hsa047130.36933419
97Antigen processing and presentation_Homo sapiens_hsa046120.36272867
98Fatty acid elongation_Homo sapiens_hsa000620.35727636
99Arginine and proline metabolism_Homo sapiens_hsa003300.35383335
100Calcium signaling pathway_Homo sapiens_hsa040200.34245288

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