GRINA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.72964350
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.66509338
3sodium ion export (GO:0071436)4.15725741
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.10657802
5locomotory exploration behavior (GO:0035641)4.07751616
6cellular potassium ion homeostasis (GO:0030007)4.05896420
7synaptic vesicle exocytosis (GO:0016079)3.87628865
8protein localization to endosome (GO:0036010)3.80289645
9glutamate secretion (GO:0014047)3.69419364
10negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.66994551
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.63964892
12positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.63106534
13response to peptidoglycan (GO:0032494)3.59430447
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.51862223
15regulation of synaptic vesicle exocytosis (GO:2000300)3.50278165
16negative regulation of erythrocyte differentiation (GO:0045647)3.49814770
17neuromuscular process controlling posture (GO:0050884)3.48312534
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46699447
19proline transport (GO:0015824)3.43666046
20neurotransmitter secretion (GO:0007269)3.38156540
21glycine transport (GO:0015816)3.30192779
22cell communication by electrical coupling (GO:0010644)3.29852333
23alanine transport (GO:0032328)3.27088138
24regulation of early endosome to late endosome transport (GO:2000641)3.26905556
25lipopolysaccharide-mediated signaling pathway (GO:0031663)3.24777723
26regulation of synaptic vesicle transport (GO:1902803)3.22557072
27vocalization behavior (GO:0071625)3.16401616
28regulation of neuronal synaptic plasticity (GO:0048168)3.15622811
29macrophage activation involved in immune response (GO:0002281)3.14734856
30gamma-aminobutyric acid transport (GO:0015812)3.14665455
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14212919
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.14212919
33modulation by symbiont of host immune response (GO:0052553)3.14212919
34positive regulation by symbiont of host defense response (GO:0052509)3.14212919
35modulation by symbiont of host defense response (GO:0052031)3.14212919
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14212919
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.12436123
38regulation of glutamate receptor signaling pathway (GO:1900449)3.09212130
39neurotransmitter-gated ion channel clustering (GO:0072578)3.06696039
40neuronal action potential propagation (GO:0019227)3.05843283
41cellular sodium ion homeostasis (GO:0006883)3.04426028
42positive regulation of Cdc42 GTPase activity (GO:0043089)2.99379044
43barbed-end actin filament capping (GO:0051016)2.98810034
44positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.98470849
45exploration behavior (GO:0035640)2.96674330
46ionotropic glutamate receptor signaling pathway (GO:0035235)2.93462704
47negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.93410363
48regulation of T-helper 2 cell differentiation (GO:0045628)2.91491022
49regulation of synapse structural plasticity (GO:0051823)2.88218608
50activation of protein kinase A activity (GO:0034199)2.85539082
51mannose metabolic process (GO:0006013)2.84592327
52protein localization to synapse (GO:0035418)2.83918898
53NIK/NF-kappaB signaling (GO:0038061)2.82008998
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81772321
55regulation of long-term neuronal synaptic plasticity (GO:0048169)2.79928203
56activation of MAPKKK activity (GO:0000185)2.79849955
57modulation by symbiont of host cellular process (GO:0044068)2.79807546
58negative regulation of interleukin-12 production (GO:0032695)2.79135328
59stress fiber assembly (GO:0043149)2.78007325
60synaptic vesicle endocytosis (GO:0048488)2.77921356
61Golgi transport vesicle coating (GO:0048200)2.77853602
62COPI coating of Golgi vesicle (GO:0048205)2.77853602
63neuromuscular process controlling balance (GO:0050885)2.75144673
64potassium ion import (GO:0010107)2.74355120
65cerebellar Purkinje cell differentiation (GO:0021702)2.72917722
66protein retention in ER lumen (GO:0006621)2.72817483
67glycosphingolipid catabolic process (GO:0046479)2.72505553
68neurotransmitter transport (GO:0006836)2.71234103
69long-term memory (GO:0007616)2.69166079
70detection of molecule of bacterial origin (GO:0032490)2.68618402
71epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68374619
72regulation of clathrin-mediated endocytosis (GO:2000369)2.68025931
73adhesion of symbiont to host (GO:0044406)2.66316197
74positive regulation of cellular amide metabolic process (GO:0034250)2.62750650
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62361706
76layer formation in cerebral cortex (GO:0021819)2.59838627
77glutamate receptor signaling pathway (GO:0007215)2.59705856
78potassium ion homeostasis (GO:0055075)2.59607834
79membrane depolarization during action potential (GO:0086010)2.59144497
80germinal center formation (GO:0002467)2.57643187
81positive regulation of vesicle fusion (GO:0031340)2.57539846
82synaptic transmission, glutamatergic (GO:0035249)2.56798905
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.56749832
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.56654643
85positive regulation of synaptic transmission, GABAergic (GO:0032230)2.56139403
86maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55934720
87response to muramyl dipeptide (GO:0032495)2.55127958
88regulation of neurotransmitter levels (GO:0001505)2.54786983
89cellular response to thyroid hormone stimulus (GO:0097067)2.54251496
90positive regulation of receptor recycling (GO:0001921)2.53021672
91cytoskeletal anchoring at plasma membrane (GO:0007016)2.52584389
92regulation of excitatory postsynaptic membrane potential (GO:0060079)2.52397081
93adhesion of symbiont to host cell (GO:0044650)2.51534488
94virion attachment to host cell (GO:0019062)2.51534488
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50482745
96mating behavior (GO:0007617)2.48287759
97regulation of ARF protein signal transduction (GO:0032012)2.48276340
98positive regulation of synapse maturation (GO:0090129)2.47513406
99negative regulation of cell killing (GO:0031342)2.47491000
100negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47491000
101regulation of vitamin D biosynthetic process (GO:0060556)2.45857842
102cellular response to type I interferon (GO:0071357)2.45009756
103type I interferon signaling pathway (GO:0060337)2.45009756
104response to laminar fluid shear stress (GO:0034616)2.44683987
105cell migration in hindbrain (GO:0021535)2.44507443
106detection of other organism (GO:0098543)2.43326489
107response to type I interferon (GO:0034340)2.42361793
108regulation of vesicle fusion (GO:0031338)2.42012004
109detection of external biotic stimulus (GO:0098581)2.41506425
110regulation of amyloid precursor protein catabolic process (GO:1902991)2.40523984
111regulation of synaptic plasticity (GO:0048167)2.40395696
112T-helper 1 type immune response (GO:0042088)2.39909355
113regulation of membrane protein ectodomain proteolysis (GO:0051043)2.39768155
114neuron-neuron synaptic transmission (GO:0007270)2.39536132
115regulation of postsynaptic membrane potential (GO:0060078)2.38876813
116regulation of cholesterol storage (GO:0010885)2.38650765
117regulation of extracellular matrix disassembly (GO:0010715)2.38631184
118positive regulation of membrane potential (GO:0045838)2.38396384
119regulation of leukocyte degranulation (GO:0043300)2.38317367
120glycolipid catabolic process (GO:0019377)2.38259320
121regulation of synaptic transmission, glutamatergic (GO:0051966)2.36755124
122positive regulation of type 2 immune response (GO:0002830)2.36501256
123regulation of neurotransmitter secretion (GO:0046928)2.36453165
124semaphorin-plexin signaling pathway (GO:0071526)2.36093536
125detection of bacterium (GO:0016045)2.36084524
126response to thyroid hormone (GO:0097066)2.35909298
127glucose 6-phosphate metabolic process (GO:0051156)2.35598430
128myeloid dendritic cell differentiation (GO:0043011)2.35564987
129positive regulation of protein dephosphorylation (GO:0035307)2.35410375
130negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.34388295
131neutrophil activation involved in immune response (GO:0002283)2.34301978
132regulation of glucose import in response to insulin stimulus (GO:2001273)2.33923418
133immunoglobulin mediated immune response (GO:0016064)2.33698056
134positive regulation of extracellular matrix organization (GO:1903055)2.32375910
135cerebellar Purkinje cell layer development (GO:0021680)2.32292188
136signal complex assembly (GO:0007172)2.31908316
137retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.31125379
138amyloid precursor protein catabolic process (GO:0042987)2.30355139
139neuromuscular process (GO:0050905)2.29540922
140negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.27107998
141endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.26658250
142prepulse inhibition (GO:0060134)2.26652070
143innervation (GO:0060384)2.26573660
144regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.26206145
145amino sugar catabolic process (GO:0046348)2.25089464
146cell-cell junction maintenance (GO:0045217)2.25022004
147negative regulation of cytokine production involved in immune response (GO:0002719)2.24325437
148regulation of neurotransmitter transport (GO:0051588)2.23416435
149membrane repolarization (GO:0086009)2.23383458
150regulation of macrophage cytokine production (GO:0010935)2.23028604
151response to auditory stimulus (GO:0010996)2.22885698
152regulation of interferon-beta biosynthetic process (GO:0045357)2.22565129
153positive regulation of fibroblast migration (GO:0010763)2.22521129
154regulation of beta-amyloid formation (GO:1902003)2.22313814
155dopamine receptor signaling pathway (GO:0007212)2.21482240
156regulation of synaptic transmission, dopaminergic (GO:0032225)2.21455034
157membrane depolarization (GO:0051899)2.21381320
158dendrite morphogenesis (GO:0048813)2.21206313
159modulation by virus of host process (GO:0019054)2.21011627
160regulation of type 2 immune response (GO:0002828)2.20713513
161pinocytosis (GO:0006907)2.20406883
162antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.20269203
163positive regulation of macrophage cytokine production (GO:0060907)2.20255021
164positive regulation of synaptic transmission (GO:0050806)2.20248025
165L-amino acid import (GO:0043092)2.19164129
166response to manganese ion (GO:0010042)2.18665795
167positive regulation of potassium ion transmembrane transport (GO:1901381)2.18449884
168cell communication involved in cardiac conduction (GO:0086065)2.18400099
169membrane hyperpolarization (GO:0060081)2.18229257
170interferon-gamma-mediated signaling pathway (GO:0060333)2.16852854
171G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.16470397
172long-term synaptic potentiation (GO:0060291)2.16425677
173vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.15811245
174regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.15662634
175CDP-diacylglycerol metabolic process (GO:0046341)2.15631838
176basement membrane organization (GO:0071711)2.15625621
177regulation of type I interferon-mediated signaling pathway (GO:0060338)2.15295812
178positive regulation of sodium ion transport (GO:0010765)2.15100684
179positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.14447442
180regulation of synaptic transmission (GO:0050804)2.14413626
181suckling behavior (GO:0001967)2.14229948
182antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.14090490
183activation of Rac GTPase activity (GO:0032863)2.14000824
184regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.13869730
185negative regulation of cell size (GO:0045792)2.13519188
186regulation of myeloid leukocyte mediated immunity (GO:0002886)2.13505126
187regulation of mast cell degranulation (GO:0043304)2.13325101
188negative regulation of protein oligomerization (GO:0032460)2.13149667
189low-density lipoprotein particle clearance (GO:0034383)2.13147323
190regulation of defense response to virus by virus (GO:0050690)2.12906583
191neuron cell-cell adhesion (GO:0007158)2.12620357
192G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.11886780
193regulation of podosome assembly (GO:0071801)2.11006264
194apoptotic cell clearance (GO:0043277)2.10997410
195regulation of regulated secretory pathway (GO:1903305)2.10513193
196regulation of dendritic cell antigen processing and presentation (GO:0002604)2.09991312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.26878091
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.94061883
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.82576553
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.48318820
5VDR_21846776_ChIP-Seq_THP-1_Human2.46154951
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42832832
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.39642292
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27133677
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26534992
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23991336
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22334107
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.16357215
13DROSHA_22980978_ChIP-Seq_HELA_Human2.16354946
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16116819
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14910599
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14057445
17REST_21632747_ChIP-Seq_MESCs_Mouse2.08271839
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.07983544
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06501690
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02995537
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02995537
22TCF7_22412390_ChIP-Seq_EML_Mouse1.93387818
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.91607619
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88910729
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87570072
26* LXR_22292898_ChIP-Seq_THP-1_Human1.84887807
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84808847
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83606542
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81814619
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80963164
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79533786
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.78469470
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78339949
34VDR_24763502_ChIP-Seq_THP-1_Human1.75776440
35* MYC_22102868_ChIP-Seq_BL_Human1.75208630
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70743111
37* KDM2B_26808549_Chip-Seq_K562_Human1.70368289
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67839931
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63284623
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62477968
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.62177103
42GBX2_23144817_ChIP-Seq_PC3_Human1.60540189
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58477452
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57890645
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.57045415
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51656369
47ZNF263_19887448_ChIP-Seq_K562_Human1.51031138
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.50715777
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50695646
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.50515216
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49830088
52CLOCK_20551151_ChIP-Seq_293T_Human1.49364556
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47369340
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46945840
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.45429041
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45289382
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43746708
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40778938
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.39814862
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38587139
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38207885
62* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37447310
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.37000222
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.35665009
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35090975
66* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34333281
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.32725085
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30315446
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29975456
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29522644
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28930971
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28901941
73* IRF8_27001747_Chip-Seq_BMDM_Mouse1.28199290
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27049430
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.26937238
76MAF_26560356_Chip-Seq_TH1_Human1.26567183
77* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26199265
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26000444
79* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25704735
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25694856
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25082109
82GATA1_19941826_ChIP-Seq_K562_Human1.23646690
83CTCF_27219007_Chip-Seq_Bcells_Human1.22954947
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22649137
85SPI1_23127762_ChIP-Seq_K562_Human1.19871613
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18275289
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17404773
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.16257578
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15844492
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14682271
91SMC4_20622854_ChIP-Seq_HELA_Human1.14577221
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14342898
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.12672239
94LXR_22158963_ChIP-Seq_LIVER_Mouse1.11878194
95KDM2B_26808549_Chip-Seq_DND41_Human1.11801673
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.11728686
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11480644
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.11442545
99TET1_21490601_ChIP-Seq_MESCs_Mouse1.11236399
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10475672
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09615475
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.07342921
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05540673
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04978937
105ATF3_27146783_Chip-Seq_COLON_Human1.04904922
106MAF_26560356_Chip-Seq_TH2_Human1.03067255
107UTX_26944678_Chip-Seq_JUKART_Human1.02888466
108* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02272038
109STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02129724
110TP53_22127205_ChIP-Seq_IMR90_Human1.02064097
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01811988
112* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01051702
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00740380
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99631759
115* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97968152
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97928125
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97335174
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96959091
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96642830
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96356754
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95921582
122NCOR1_26117541_ChIP-Seq_K562_Human0.95829616
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94215834
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.93715342
125* P68_20966046_ChIP-Seq_HELA_Human0.91812805
126ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90719844
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90614557
128KLF4_19829295_ChIP-Seq_ESCs_Human0.89896013
129RACK7_27058665_Chip-Seq_MCF-7_Human0.89538336
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89206310
131AR_21572438_ChIP-Seq_LNCaP_Human0.89109476
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88808437
133MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.88780610
134AR_19668381_ChIP-Seq_PC3_Human0.88399824
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86516711
136CREB1_26743006_Chip-Seq_LNCaP_Human0.85997254
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85081998
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83897858
139TRIM28_21343339_ChIP-Seq_HEK293_Human0.83502967
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82619473
141* OCT4_19829295_ChIP-Seq_ESCs_Human0.82354837
142GATA2_19941826_ChIP-Seq_K562_Human0.82278941
143CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81861481
144OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81543954
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81187575
146* TP53_20018659_ChIP-ChIP_R1E_Mouse0.80990462
147ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80453921
148* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.79522916
149RXR_22108803_ChIP-Seq_LS180_Human0.79075712
150TET1_21451524_ChIP-Seq_MESCs_Mouse0.79057295
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79030424
152RING1B_27294783_Chip-Seq_NPCs_Mouse0.78144480
153BCL6_27268052_Chip-Seq_Bcells_Human0.77574201
154SA1_27219007_Chip-Seq_Bcells_Human0.76296569
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.76054300
156SMAD4_21741376_ChIP-Seq_HESCs_Human0.75909422
157* TP63_22573176_ChIP-Seq_HFKS_Human0.75494156
158SA1_27219007_Chip-Seq_ERYTHROID_Human0.75372039
159KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74898441
160BCOR_27268052_Chip-Seq_Bcells_Human0.74774492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.33625040
2MP0003303_peritoneal_inflammation3.72469058
3MP0003705_abnormal_hypodermis_morpholog3.44246429
4MP0003635_abnormal_synaptic_transmissio3.16729639
5MP0005451_abnormal_body_composition2.89641842
6MP0003436_decreased_susceptibility_to2.84482470
7MP0004858_abnormal_nervous_system2.79502741
8MP0004510_myositis2.69554066
9MP0002822_catalepsy2.66856576
10MP0002064_seizures2.60776661
11MP0009046_muscle_twitch2.59488566
12MP0009745_abnormal_behavioral_response2.53765436
13MP0003329_amyloid_beta_deposits2.51620716
14MP0004270_analgesia2.51041651
15MP0002063_abnormal_learning/memory/cond2.49701166
16MP0003880_abnormal_central_pattern2.43805936
17MP0003300_gastrointestinal_ulcer2.43572583
18MP0001968_abnormal_touch/_nociception2.30184235
19MP0002735_abnormal_chemical_nociception2.16007128
20MP0003075_altered_response_to2.09254145
21MP0002909_abnormal_adrenal_gland2.06485395
22MP0001501_abnormal_sleep_pattern2.06260211
23MP0002572_abnormal_emotion/affect_behav2.05530991
24MP0008260_abnormal_autophagy2.05492729
25MP0006082_CNS_inflammation2.04118660
26MP0002733_abnormal_thermal_nociception1.92131959
27MP0002734_abnormal_mechanical_nocicepti1.89280403
28MP0003724_increased_susceptibility_to1.88687512
29MP0003172_abnormal_lysosome_physiology1.87311261
30MP0002272_abnormal_nervous_system1.86469868
31MP0003656_abnormal_erythrocyte_physiolo1.86100999
32MP0002148_abnormal_hypersensitivity_rea1.85686021
33MP0002419_abnormal_innate_immunity1.84800673
34MP0002736_abnormal_nociception_after1.82978502
35MP0008438_abnormal_cutaneous_collagen1.81498576
36MP0003453_abnormal_keratinocyte_physiol1.81286724
37MP0009785_altered_susceptibility_to1.79193409
38MP0001970_abnormal_pain_threshold1.78339415
39MP0005058_abnormal_lysosome_morphology1.76764293
40MP0001533_abnormal_skeleton_physiology1.76400177
41MP0004947_skin_inflammation1.76175507
42MP0005025_abnormal_response_to1.75216828
43MP0005423_abnormal_somatic_nervous1.69808110
44MP0008569_lethality_at_weaning1.64993684
45MP0003633_abnormal_nervous_system1.64126138
46MP0002837_dystrophic_cardiac_calcinosis1.63971784
47MP0004130_abnormal_muscle_cell1.63917505
48MP0000604_amyloidosis1.63020693
49MP0005000_abnormal_immune_tolerance1.62410577
50MP0001849_ear_inflammation1.59872434
51MP0003091_abnormal_cell_migration1.57895533
52MP0003566_abnormal_cell_adhesion1.57743090
53MP0000858_altered_metastatic_potential1.57210390
54MP0001502_abnormal_circadian_rhythm1.56346620
55MP0005076_abnormal_cell_differentiation1.54666994
56MP0000343_altered_response_to1.54572476
57MP0001790_abnormal_immune_system1.54105046
58MP0005387_immune_system_phenotype1.54105046
59MP0001835_abnormal_antigen_presentation1.53619970
60MP0001440_abnormal_grooming_behavior1.51831822
61MP0005167_abnormal_blood-brain_barrier1.50960264
62MP0002067_abnormal_sensory_capabilities1.50808650
63MP0002998_abnormal_bone_remodeling1.50645613
64MP0005551_abnormal_eye_electrophysiolog1.50602915
65MP0000685_abnormal_immune_system1.48326406
66MP0009780_abnormal_chondrocyte_physiolo1.47436639
67MP0001486_abnormal_startle_reflex1.44397434
68MP0004811_abnormal_neuron_physiology1.43131872
69MP0008961_abnormal_basal_metabolism1.42247765
70MP0002877_abnormal_melanocyte_morpholog1.41803796
71MP0002653_abnormal_ependyma_morphology1.39530776
72MP0004043_abnormal_pH_regulation1.37689768
73MP0003690_abnormal_glial_cell1.36971481
74MP0005535_abnormal_body_temperature1.35790258
75MP0005360_urolithiasis1.34946014
76MP0003879_abnormal_hair_cell1.34085730
77MP0005257_abnormal_intraocular_pressure1.33600834
78MP0003279_aneurysm1.33265148
79MP0004233_abnormal_muscle_weight1.29474405
80MP0000920_abnormal_myelination1.28322636
81MP0010234_abnormal_vibrissa_follicle1.27999452
82MP0004885_abnormal_endolymph1.24561235
83MP0002139_abnormal_hepatobiliary_system1.23760269
84MP0010155_abnormal_intestine_physiology1.22059075
85MP0003631_nervous_system_phenotype1.21304007
86MP0003448_altered_tumor_morphology1.20388895
87MP0010329_abnormal_lipoprotein_level1.19077876
88MP0002090_abnormal_vision1.16836902
89MP0000751_myopathy1.16074707
90MP0002723_abnormal_immune_serum1.15784305
91MP0005670_abnormal_white_adipose1.14290118
92MP0002452_abnormal_antigen_presenting1.14199768
93MP0001348_abnormal_lacrimal_gland1.13549088
94MP0005464_abnormal_platelet_physiology1.13491152
95MP0003191_abnormal_cellular_cholesterol1.12261226
96MP0008874_decreased_physiological_sensi1.12255552
97MP0005666_abnormal_adipose_tissue1.09648280
98MP0000955_abnormal_spinal_cord1.09606314
99MP0002066_abnormal_motor_capabilities/c1.09294170
100MP0004924_abnormal_behavior1.08985177
101MP0005386_behavior/neurological_phenoty1.08985177
102MP0010386_abnormal_urinary_bladder1.08979831
103MP0006072_abnormal_retinal_apoptosis1.07939358
104MP0009840_abnormal_foam_cell1.07688196
105MP0001845_abnormal_inflammatory_respons1.07575871
106MP0009764_decreased_sensitivity_to1.07247658
107MP0002184_abnormal_innervation1.07169711
108MP0005409_darkened_coat_color1.06945293
109MP0008469_abnormal_protein_level1.06610267
110MP0005023_abnormal_wound_healing1.06345997
111MP0002882_abnormal_neuron_morphology1.04984283
112MP0000013_abnormal_adipose_tissue1.04559217
113MP0001958_emphysema1.04166443
114MP0008872_abnormal_physiological_respon1.03809906
115MP0005332_abnormal_amino_acid1.03337793
116MP0003634_abnormal_glial_cell1.02543727
117MP0003045_fibrosis1.01517258
118MP0002229_neurodegeneration1.01069736
119MP0002089_abnormal_postnatal_growth/wei1.00895307
120MP0004019_abnormal_vitamin_homeostasis1.00818305
121MP0005310_abnormal_salivary_gland1.00610541
122MP0004185_abnormal_adipocyte_glucose1.00347772
123MP0005083_abnormal_biliary_tract0.99639907
124MP0004142_abnormal_muscle_tone0.98123727
125MP0005645_abnormal_hypothalamus_physiol0.97656937
126MP0001800_abnormal_humoral_immune0.97302739
127MP0001819_abnormal_immune_cell0.96722603
128MP0001853_heart_inflammation0.96248849
129MP0002420_abnormal_adaptive_immunity0.95614899
130MP0002557_abnormal_social/conspecific_i0.95430044
131MP0002254_reproductive_system_inflammat0.94945746
132MP0002796_impaired_skin_barrier0.94884869
133MP0005390_skeleton_phenotype0.94741245
134MP0005253_abnormal_eye_physiology0.94388379
135MP0005375_adipose_tissue_phenotype0.94117267
136MP0002118_abnormal_lipid_homeostasis0.94013390
137MP0005584_abnormal_enzyme/coenzyme_acti0.93961360
138MP0005365_abnormal_bile_salt0.92582924
139MP0005646_abnormal_pituitary_gland0.92022281
140MP0005397_hematopoietic_system_phenotyp0.91323108
141MP0001545_abnormal_hematopoietic_system0.91323108
142MP0002069_abnormal_eating/drinking_beha0.91227484
143MP0003183_abnormal_peptide_metabolism0.89936485
144MP0005166_decreased_susceptibility_to0.89867627
145MP0005671_abnormal_response_to0.89612710
146MP0002971_abnormal_brown_adipose0.88814951
147MP0000678_abnormal_parathyroid_gland0.87997136
148MP0002638_abnormal_pupillary_reflex0.87548391
149MP0003646_muscle_fatigue0.85671048
150MP0001765_abnormal_ion_homeostasis0.85472739
151MP0003283_abnormal_digestive_organ0.84438089
152MP0001984_abnormal_olfaction0.83993616
153MP0009278_abnormal_bone_marrow0.83373886
154MP0009333_abnormal_splenocyte_physiolog0.83117863
155MP0005448_abnormal_energy_balance0.82614801
156MP0003011_delayed_dark_adaptation0.82047570
157MP0005164_abnormal_response_to0.81462459
158MP0002896_abnormal_bone_mineralization0.81236531
159MP0006276_abnormal_autonomic_nervous0.81219172
160MP0005165_increased_susceptibility_to0.79524562
161MP0004147_increased_porphyrin_level0.78502059
162MP0002405_respiratory_system_inflammati0.77299696
163MP0002332_abnormal_exercise_endurance0.75072004
164MP0003828_pulmonary_edema0.74136363
165MP0005085_abnormal_gallbladder_physiolo0.73869454
166MP0000767_abnormal_smooth_muscle0.73399611
167MP0002876_abnormal_thyroid_physiology0.73358768
168MP0000778_abnormal_nervous_system0.72875111
169MP0001756_abnormal_urination0.72132175
170MP0002078_abnormal_glucose_homeostasis0.71621840
171MP0001542_abnormal_bone_strength0.71455579
172MP0003795_abnormal_bone_structure0.71270870
173MP0000681_abnormal_thyroid_gland0.69976862
174MP0008004_abnormal_stomach_pH0.69457963
175MP0004264_abnormal_extraembryonic_tissu0.67930087
176MP0000249_abnormal_blood_vessel0.67700925
177MP0001851_eye_inflammation0.67476314
178MP0005623_abnormal_meninges_morphology0.65420169
179MP0000747_muscle_weakness0.65380575

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.25593146
2Focal motor seizures (HP:0011153)4.62742780
3Abnormality of glycolipid metabolism (HP:0010969)4.54333135
4Abnormality of liposaccharide metabolism (HP:0010968)4.54333135
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.54333135
6Visual hallucinations (HP:0002367)3.82995057
7Focal seizures (HP:0007359)3.70964675
8Systemic lupus erythematosus (HP:0002725)3.53315823
9Action tremor (HP:0002345)3.50637647
10Supranuclear gaze palsy (HP:0000605)3.28168652
11Abnormality of macrophages (HP:0004311)3.04025124
12Epileptic encephalopathy (HP:0200134)3.03168749
13Vertebral compression fractures (HP:0002953)3.01606500
14Progressive cerebellar ataxia (HP:0002073)2.95092933
15Febrile seizures (HP:0002373)2.91721366
16Abnormal eating behavior (HP:0100738)2.91621937
17Hypercortisolism (HP:0001578)2.91442049
18Atonic seizures (HP:0010819)2.89143141
19Depression (HP:0000716)2.88670835
20Abnormality of the lower motor neuron (HP:0002366)2.86650880
21Dysostosis multiplex (HP:0000943)2.84905862
22Generalized tonic-clonic seizures (HP:0002069)2.84777343
23Dysdiadochokinesis (HP:0002075)2.79994035
24Eczematoid dermatitis (HP:0000976)2.79322151
25Status epilepticus (HP:0002133)2.69109763
26Postural instability (HP:0002172)2.68952613
27Absence seizures (HP:0002121)2.67218154
28Increased circulating renin level (HP:0000848)2.64112849
29Nuclear cataract (HP:0100018)2.63013407
30Urinary glycosaminoglycan excretion (HP:0003541)2.61058417
31Mucopolysacchariduria (HP:0008155)2.61058417
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.58652979
33Abnormality of polysaccharide metabolism (HP:0011012)2.58652979
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.58652979
35Annular pancreas (HP:0001734)2.53252562
36Cholecystitis (HP:0001082)2.52068484
37Abnormal gallbladder physiology (HP:0012438)2.52068484
38Cerebral aneurysm (HP:0004944)2.51590467
39Protrusio acetabuli (HP:0003179)2.50897232
40Anxiety (HP:0000739)2.49659886
41Neurofibrillary tangles (HP:0002185)2.47882606
42Torticollis (HP:0000473)2.47376267
43Hemiplegia (HP:0002301)2.47234333
44Obstructive sleep apnea (HP:0002870)2.45600563
45Thin bony cortex (HP:0002753)2.44124473
46Increased cerebral lipofuscin (HP:0011813)2.43906539
47Dialeptic seizures (HP:0011146)2.42203920
48J-shaped sella turcica (HP:0002680)2.40950835
49Central scotoma (HP:0000603)2.40201460
50Ankle clonus (HP:0011448)2.39249766
51Growth hormone excess (HP:0000845)2.38631410
52Amyloidosis (HP:0011034)2.37948234
53Abnormality of complement system (HP:0005339)2.37778491
54Hyperacusis (HP:0010780)2.36828581
55Pheochromocytoma (HP:0002666)2.36542468
56Apathy (HP:0000741)2.35899631
57Gout (HP:0001997)2.34940011
58Glomerulonephritis (HP:0000099)2.34702957
59Cerebral inclusion bodies (HP:0100314)2.32660203
60Cervical subluxation (HP:0003308)2.32201359
61Intention tremor (HP:0002080)2.31944421
62Failure to thrive in infancy (HP:0001531)2.31664512
63Diminished motivation (HP:0000745)2.31657205
64Distal lower limb muscle weakness (HP:0009053)2.30121477
65Recurrent abscess formation (HP:0002722)2.29580025
66Achilles tendon contracture (HP:0001771)2.28350347
67Turricephaly (HP:0000262)2.28194543
68Global brain atrophy (HP:0002283)2.27781950
69Dysmetric saccades (HP:0000641)2.26061730
70Deep venous thrombosis (HP:0002625)2.25751905
71Premature rupture of membranes (HP:0001788)2.25201361
72Complement deficiency (HP:0004431)2.23749532
73Abnormal social behavior (HP:0012433)2.23717619
74Impaired social interactions (HP:0000735)2.23717619
75Dysmetria (HP:0001310)2.22773679
76Focal dystonia (HP:0004373)2.22167880
77Vacuolated lymphocytes (HP:0001922)2.21994256
78Hyperparathyroidism (HP:0000843)2.21854444
79Interstitial pulmonary disease (HP:0006530)2.21635626
80Orchitis (HP:0100796)2.18384009
81Adrenal overactivity (HP:0002717)2.18142161
82Purpura (HP:0000979)2.16987700
83Polyphagia (HP:0002591)2.16539636
84Recurrent bacterial skin infections (HP:0005406)2.16482785
85Recurrent gram-negative bacterial infections (HP:0005420)2.15156222
86Abnormality of the Achilles tendon (HP:0005109)2.13433063
87Asymmetric septal hypertrophy (HP:0001670)2.12355796
88Craniofacial dystonia (HP:0012179)2.11582407
89Insomnia (HP:0100785)2.09741221
90Mutism (HP:0002300)2.08815913
91Oligomenorrhea (HP:0000876)2.08511507
92Ketoacidosis (HP:0001993)2.08263684
93Hypoventilation (HP:0002791)2.07746379
94Diplopia (HP:0000651)2.07594892
95Abnormality of binocular vision (HP:0011514)2.07594892
96Truncal ataxia (HP:0002078)2.07590608
97Congenital stationary night blindness (HP:0007642)2.06033482
98Impaired vibration sensation in the lower limbs (HP:0002166)2.04748851
99Exercise-induced myalgia (HP:0003738)2.03994868
100Hyperactive renin-angiotensin system (HP:0000841)2.03226710
101Hemiparesis (HP:0001269)2.02023840
102Sensorimotor neuropathy (HP:0007141)2.01751945
103Cholelithiasis (HP:0001081)2.01175720
104Poor eye contact (HP:0000817)2.00192733
105Myositis (HP:0100614)1.99111428
106Pathologic fracture (HP:0002756)1.98829244
107Genetic anticipation (HP:0003743)1.98034458
108Polycythemia (HP:0001901)1.97698889
109Neuroendocrine neoplasm (HP:0100634)1.97559496
110Bradykinesia (HP:0002067)1.97533274
111Bone pain (HP:0002653)1.97290833
112Neuronal loss in central nervous system (HP:0002529)1.96601677
113Distal upper limb amyotrophy (HP:0007149)1.96284191
114Upper limb amyotrophy (HP:0009129)1.96284191
115Hemorrhage of the eye (HP:0011885)1.95115727
116Cellulitis (HP:0100658)1.95073690
117Polygenic inheritance (HP:0010982)1.92471943
118Psychosis (HP:0000709)1.92434629
119Retinal atrophy (HP:0001105)1.91803708
120Flat acetabular roof (HP:0003180)1.91453323
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90639226
122Myocardial infarction (HP:0001658)1.88862674
123Mediastinal lymphadenopathy (HP:0100721)1.88502013
124Increased serum ferritin (HP:0003281)1.88014669
125Ventricular fibrillation (HP:0001663)1.87433241
126Hand muscle atrophy (HP:0009130)1.86803623
127Amblyopia (HP:0000646)1.86303008
128Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85983881
129Axonal loss (HP:0003447)1.84734195
130Urinary bladder sphincter dysfunction (HP:0002839)1.84416785
131Broad face (HP:0000283)1.84192139
132Segmental peripheral demyelination/remyelination (HP:0003481)1.84041521
133Gingivitis (HP:0000230)1.84015958
134Rigidity (HP:0002063)1.82816465
135Pigmentary retinal degeneration (HP:0001146)1.82528348
136Increased neuronal autofluorescent lipopigment (HP:0002074)1.82401719
137Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81711064
138Ketosis (HP:0001946)1.81641784
139Dementia (HP:0000726)1.81538632
140Gaze-evoked nystagmus (HP:0000640)1.80271542
141Reticulocytosis (HP:0001923)1.80104182
142Abnormal gallbladder morphology (HP:0012437)1.79534021
143Progressive neurologic deterioration (HP:0002344)1.79470418
144Slow saccadic eye movements (HP:0000514)1.78173184
145Disinhibition (HP:0000734)1.77359752
146Increased connective tissue (HP:0009025)1.76689792
147Emphysema (HP:0002097)1.76073071
148Diaphragmatic weakness (HP:0009113)1.75821575
149Gastrointestinal stroma tumor (HP:0100723)1.75076042
150Abnormality of the thoracic spine (HP:0100711)1.75046788
151Agitation (HP:0000713)1.74112684
152Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73515571
153Abnormality of the nasal mucosa (HP:0000433)1.72872930
154Rapidly progressive (HP:0003678)1.72783407
155Upper motor neuron abnormality (HP:0002127)1.72489325
156Distal lower limb amyotrophy (HP:0008944)1.72225602
157Thoracic kyphosis (HP:0002942)1.70931671
158Aneurysm (HP:0002617)1.70191564
159Blue sclerae (HP:0000592)1.69717648
160Clumsiness (HP:0002312)1.69570641
161Loss of speech (HP:0002371)1.69556193
162Impaired smooth pursuit (HP:0007772)1.69528794
163Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.69130798
164Prolonged neonatal jaundice (HP:0006579)1.68964064
165Optic neuritis (HP:0100653)1.66224321
166Retrobulbar optic neuritis (HP:0100654)1.66224321
167Chronic obstructive pulmonary disease (HP:0006510)1.65751014
168Obstructive lung disease (HP:0006536)1.65751014
169Hypertriglyceridemia (HP:0002155)1.61802966
170Malnutrition (HP:0004395)1.60757027
171Increased variability in muscle fiber diameter (HP:0003557)1.60718788
172Nephritis (HP:0000123)1.58850713
173Bulbar palsy (HP:0001283)1.57757085
174Increased IgE level (HP:0003212)1.57563643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.31724444
2NTRK33.18845354
3IRAK33.13198512
4EPHA42.95294861
5TRIB32.28635487
6DAPK22.25779746
7KSR22.24115800
8PRKD32.13975413
9NME22.06953696
10PINK12.02245034
11SMG12.01636205
12TESK11.95668757
13PAK61.94149181
14MINK11.89219615
15NTRK11.88407412
16TAOK21.87773834
17ERN11.81203872
18CAMKK11.71090115
19ICK1.68461584
20STK381.62804125
21TBK11.57494800
22RIPK11.57071898
23MAP3K41.56590111
24MAP2K31.54596569
25RIPK41.54278796
26MAP3K31.45301718
27DAPK11.44661421
28MAP2K41.43080678
29PHKG21.39394550
30PHKG11.39394550
31ARAF1.38487174
32GRK51.37851581
33FGFR41.34992544
34NTRK21.34260244
35TYRO31.33833061
36MAP3K121.33417016
37DDR21.32738890
38LMTK21.29294542
39TYK21.29021043
40TESK21.24729514
41MAP3K141.24350760
42PRKCH1.23862523
43BMX1.23375306
44IRAK41.22693610
45FGR1.22149378
46BLK1.17470614
47CDK51.17388630
48SGK2231.13734078
49SGK4941.13734078
50TAOK11.13633053
51MAP3K131.12419840
52EEF2K1.12324698
53PRPF4B1.11565415
54EPHA21.10781473
55MAP4K11.10460799
56SIK21.06706670
57SGK31.06515316
58WNK41.04525644
59PIM21.03884243
60PTK2B1.03289843
61PDGFRA1.01709176
62RET1.01423374
63MAP2K71.00333658
64SIK30.99939322
65MAP3K110.99593721
66MAP3K60.99012591
67CAMKK20.98184376
68PTK20.97815834
69MAP3K20.96968359
70UHMK10.96774924
71MARK10.96616630
72TNK20.95582284
73ZAP700.95426061
74MAP3K10.95235761
75PAK40.92939162
76MOS0.92659290
77SIK10.89976402
78CDK120.87920398
79PTK60.87229395
80MATK0.87206911
81CAMK1G0.86194065
82PDPK10.85652777
83PRKCG0.84052495
84IRAK20.83895117
85PRKD20.83534898
86RPS6KA20.82833134
87FES0.82293532
88TGFBR20.80794956
89JAK30.80371564
90SGK20.80335458
91TTN0.79255519
92KSR10.78085111
93CAMK10.77687251
94PDK10.76397739
95GRK60.72826654
96JAK10.71450765
97MAP3K70.71238625
98CAMK1D0.68799404
99NEK10.68267234
100SGK10.67706208
101MAP2K10.66967223
102PRKCZ0.66286650
103WNK30.65702918
104MAPK150.64813726
105MAPKAPK30.64015041
106CAMK2A0.63960861
107IKBKE0.63924171
108CDC42BPA0.63310984
109MTOR0.63028794
110ABL20.62520851
111PRKAA10.62514529
112PRKG20.60203773
113HIPK20.57794605
114CSK0.57116662
115PKN20.56532252
116WNK10.56449940
117MAP2K20.56163756
118BRAF0.56022835
119ALK0.55963090
120MARK20.55811124
121GRK70.55307554
122OXSR10.54594875
123STK110.54363504
124CDK150.54231149
125CDK180.53871400
126CDK140.53437506
127RPS6KL10.52205065
128RPS6KC10.52205065
129FER0.51950848
130DYRK1B0.51861695
131JAK20.51714092
132MAPK130.50875239
133MAPK120.50820019
134CAMK40.50327281
135CHUK0.50248589
136MAPK110.50157695
137LIMK10.49762085
138CSF1R0.49634111
139PAK30.49476700
140PRKACG0.48900413
141IKBKB0.48298917
142CAMK2G0.47823053
143LATS20.47736889
144LRRK20.47129011
145EPHB10.46766754
146CDK11A0.46381647
147RPS6KA30.45135525
148SCYL20.42039339
149MAPK40.39398761
150MST1R0.38484454
151MAPK70.38075446
152PDGFRB0.37554462
153HCK0.35342929

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.94886383
2Synaptic vesicle cycle_Homo sapiens_hsa047212.94066309
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.52313704
4Nitrogen metabolism_Homo sapiens_hsa009102.26550868
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23924053
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14868665
7Nicotine addiction_Homo sapiens_hsa050332.05248847
8Osteoclast differentiation_Homo sapiens_hsa043802.01913929
9GABAergic synapse_Homo sapiens_hsa047271.95466939
10Olfactory transduction_Homo sapiens_hsa047401.93522574
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89867046
12Circadian entrainment_Homo sapiens_hsa047131.76923718
13Leishmaniasis_Homo sapiens_hsa051401.71279335
14Collecting duct acid secretion_Homo sapiens_hsa049661.67812245
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67701557
16Morphine addiction_Homo sapiens_hsa050321.61366744
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59272485
18Salivary secretion_Homo sapiens_hsa049701.57041817
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56448940
20Glutamatergic synapse_Homo sapiens_hsa047241.52708545
21Fatty acid biosynthesis_Homo sapiens_hsa000611.50192392
22Acute myeloid leukemia_Homo sapiens_hsa052211.49963972
23Insulin secretion_Homo sapiens_hsa049111.49427352
24Tuberculosis_Homo sapiens_hsa051521.47846374
25Arginine biosynthesis_Homo sapiens_hsa002201.46153899
26Long-term potentiation_Homo sapiens_hsa047201.45527724
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44428767
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44105023
29B cell receptor signaling pathway_Homo sapiens_hsa046621.40222233
30TNF signaling pathway_Homo sapiens_hsa046681.37201104
31Gastric acid secretion_Homo sapiens_hsa049711.33904424
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33347515
33Dopaminergic synapse_Homo sapiens_hsa047281.33304268
34Pertussis_Homo sapiens_hsa051331.33140904
35Amphetamine addiction_Homo sapiens_hsa050311.33090771
36Malaria_Homo sapiens_hsa051441.33087032
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30095992
38Bile secretion_Homo sapiens_hsa049761.25818780
39Toxoplasmosis_Homo sapiens_hsa051451.22945387
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22939785
41Cholinergic synapse_Homo sapiens_hsa047251.21755876
42Hepatitis C_Homo sapiens_hsa051601.21350000
43Amoebiasis_Homo sapiens_hsa051461.17735702
44Phototransduction_Homo sapiens_hsa047441.16550506
45Chronic myeloid leukemia_Homo sapiens_hsa052201.16049039
46Salmonella infection_Homo sapiens_hsa051321.15470255
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14841825
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13370719
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12496844
50Influenza A_Homo sapiens_hsa051641.12051350
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09596828
52Notch signaling pathway_Homo sapiens_hsa043301.09152554
53Renin secretion_Homo sapiens_hsa049241.07956354
54Rheumatoid arthritis_Homo sapiens_hsa053231.06440175
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06400533
56Cocaine addiction_Homo sapiens_hsa050301.05152888
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.04820266
58Phagosome_Homo sapiens_hsa041451.02804227
59Fatty acid metabolism_Homo sapiens_hsa012121.01550515
60Type II diabetes mellitus_Homo sapiens_hsa049301.00083768
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97769611
62Long-term depression_Homo sapiens_hsa047300.95819637
63Taste transduction_Homo sapiens_hsa047420.95748799
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94914369
65Oxytocin signaling pathway_Homo sapiens_hsa049210.94373853
66GnRH signaling pathway_Homo sapiens_hsa049120.92767142
67Non-small cell lung cancer_Homo sapiens_hsa052230.92638637
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92636210
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92487519
70Calcium signaling pathway_Homo sapiens_hsa040200.92240973
71Chemokine signaling pathway_Homo sapiens_hsa040620.90884184
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89857607
73Glycerolipid metabolism_Homo sapiens_hsa005610.89697035
74PPAR signaling pathway_Homo sapiens_hsa033200.89149687
75Prolactin signaling pathway_Homo sapiens_hsa049170.88789359
76Pancreatic cancer_Homo sapiens_hsa052120.88262332
77Complement and coagulation cascades_Homo sapiens_hsa046100.87528084
78Legionellosis_Homo sapiens_hsa051340.87222495
79Allograft rejection_Homo sapiens_hsa053300.87164610
80Lysosome_Homo sapiens_hsa041420.87028474
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.86632183
82cAMP signaling pathway_Homo sapiens_hsa040240.85937005
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85411541
84Glioma_Homo sapiens_hsa052140.85064765
85Renal cell carcinoma_Homo sapiens_hsa052110.85028117
86African trypanosomiasis_Homo sapiens_hsa051430.83886046
87Gap junction_Homo sapiens_hsa045400.83276576
88Galactose metabolism_Homo sapiens_hsa000520.82484401
89Pentose phosphate pathway_Homo sapiens_hsa000300.81180710
90Hepatitis B_Homo sapiens_hsa051610.80266462
91Serotonergic synapse_Homo sapiens_hsa047260.79593036
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.78762844
93Shigellosis_Homo sapiens_hsa051310.78316959
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77550478
95Butanoate metabolism_Homo sapiens_hsa006500.77126625
96Endometrial cancer_Homo sapiens_hsa052130.76896926
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76656224
98Estrogen signaling pathway_Homo sapiens_hsa049150.76634714
99Apoptosis_Homo sapiens_hsa042100.73288484
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71387345
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.71295154
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70996960
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69173795
104Dorso-ventral axis formation_Homo sapiens_hsa043200.68971151
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68519853
106Vibrio cholerae infection_Homo sapiens_hsa051100.68114938
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.68011214
108Insulin signaling pathway_Homo sapiens_hsa049100.67427630
109Phenylalanine metabolism_Homo sapiens_hsa003600.67233682
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67194289
111Viral myocarditis_Homo sapiens_hsa054160.67099808
112mTOR signaling pathway_Homo sapiens_hsa041500.66818605
113Circadian rhythm_Homo sapiens_hsa047100.66378889
114Glucagon signaling pathway_Homo sapiens_hsa049220.65530360
115Thyroid hormone synthesis_Homo sapiens_hsa049180.65402879
116Fatty acid degradation_Homo sapiens_hsa000710.65353932
117Fructose and mannose metabolism_Homo sapiens_hsa000510.65223981
118Pyruvate metabolism_Homo sapiens_hsa006200.64955810
119Graft-versus-host disease_Homo sapiens_hsa053320.64114472
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63714793
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.62355175
122Propanoate metabolism_Homo sapiens_hsa006400.62354725
123Measles_Homo sapiens_hsa051620.62206655
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61336354
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61267945
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.60998916
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60971407
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60699422
129Proteoglycans in cancer_Homo sapiens_hsa052050.60336236
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60145165
131VEGF signaling pathway_Homo sapiens_hsa043700.59390015
132Autoimmune thyroid disease_Homo sapiens_hsa053200.59155194
133HIF-1 signaling pathway_Homo sapiens_hsa040660.58688337
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58217567
135Sphingolipid metabolism_Homo sapiens_hsa006000.57082487
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.56660279
137Pancreatic secretion_Homo sapiens_hsa049720.54675454
138Mineral absorption_Homo sapiens_hsa049780.54580040
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54437846
140ErbB signaling pathway_Homo sapiens_hsa040120.54278926
141Choline metabolism in cancer_Homo sapiens_hsa052310.54058904
142Focal adhesion_Homo sapiens_hsa045100.53172956
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52037957
144Endocytosis_Homo sapiens_hsa041440.51855981
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.51617308
146Herpes simplex infection_Homo sapiens_hsa051680.51417583
147Staphylococcus aureus infection_Homo sapiens_hsa051500.50515283
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.50202586
149Jak-STAT signaling pathway_Homo sapiens_hsa046300.49659072
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.49547036
151Asthma_Homo sapiens_hsa053100.48243975
152AMPK signaling pathway_Homo sapiens_hsa041520.47930248
153Biosynthesis of amino acids_Homo sapiens_hsa012300.46895150
154Antigen processing and presentation_Homo sapiens_hsa046120.46867150
155Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46093461
156ABC transporters_Homo sapiens_hsa020100.46045071
157Insulin resistance_Homo sapiens_hsa049310.46008659
158Carbon metabolism_Homo sapiens_hsa012000.45438767
159Bladder cancer_Homo sapiens_hsa052190.45185324
160Prion diseases_Homo sapiens_hsa050200.44789172
161Vascular smooth muscle contraction_Homo sapiens_hsa042700.42133223
162Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42033167

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