GRIN2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.98394822
2vocalization behavior (GO:0071625)5.86295439
3synaptic vesicle maturation (GO:0016188)5.43254649
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.42815770
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.20948898
6locomotory exploration behavior (GO:0035641)5.15012684
7neuron cell-cell adhesion (GO:0007158)5.13289754
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06934487
9synaptic vesicle exocytosis (GO:0016079)4.80251607
10gamma-aminobutyric acid transport (GO:0015812)4.78436196
11mitochondrion transport along microtubule (GO:0047497)4.74245225
12establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.74245225
13regulation of glutamate receptor signaling pathway (GO:1900449)4.73910806
14neurotransmitter secretion (GO:0007269)4.73255317
15establishment of mitochondrion localization (GO:0051654)4.73164510
16regulation of synaptic vesicle exocytosis (GO:2000300)4.65264708
17cell-cell junction maintenance (GO:0045217)4.61641383
18glutamate secretion (GO:0014047)4.54436355
19layer formation in cerebral cortex (GO:0021819)4.53672023
20protein localization to synapse (GO:0035418)4.44541611
21* ionotropic glutamate receptor signaling pathway (GO:0035235)4.40186790
22exploration behavior (GO:0035640)4.39070616
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.34797627
24dendritic spine morphogenesis (GO:0060997)4.30711364
25cilium or flagellum-dependent cell motility (GO:0001539)4.29264040
26regulation of synaptic vesicle transport (GO:1902803)4.17163440
27axonemal dynein complex assembly (GO:0070286)3.98079359
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91471904
29pyrimidine nucleobase catabolic process (GO:0006208)3.90552551
30neurotransmitter transport (GO:0006836)3.88225868
31sperm motility (GO:0030317)3.80117339
32calcium ion-dependent exocytosis (GO:0017156)3.75199539
33regulation of neuronal synaptic plasticity (GO:0048168)3.74562098
34acrosome reaction (GO:0007340)3.73211348
35neuron recognition (GO:0008038)3.72294403
36* glutamate receptor signaling pathway (GO:0007215)3.71989220
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69178745
38planar cell polarity pathway involved in neural tube closure (GO:0090179)3.68591162
39epithelial cilium movement (GO:0003351)3.68229206
40cell junction maintenance (GO:0034331)3.63704693
41cellular potassium ion homeostasis (GO:0030007)3.63641517
42* synaptic transmission, glutamatergic (GO:0035249)3.61969735
43neuronal action potential propagation (GO:0019227)3.60817775
44regulation of neurotransmitter levels (GO:0001505)3.57827637
45synaptic vesicle endocytosis (GO:0048488)3.55833863
46skeletal muscle organ development (GO:0060538)3.54780579
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52228675
48proline transport (GO:0015824)3.50381189
49membrane depolarization during action potential (GO:0086010)3.44849179
50* neuron-neuron synaptic transmission (GO:0007270)3.43459299
51positive regulation of synaptic transmission, GABAergic (GO:0032230)3.42052261
52neuromuscular process controlling posture (GO:0050884)3.41375747
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41125125
54positive regulation of synapse maturation (GO:0090129)3.40582331
55regulation of NFAT protein import into nucleus (GO:0051532)3.39632436
56postsynaptic membrane organization (GO:0001941)3.39426987
57sodium ion export (GO:0071436)3.39226039
58activation of protein kinase A activity (GO:0034199)3.37743130
59cerebellar Purkinje cell differentiation (GO:0021702)3.37126542
60cilium movement (GO:0003341)3.35429685
61axon extension (GO:0048675)3.34355275
62regulation of translational fidelity (GO:0006450)3.34039938
63regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.31216887
64axonal fasciculation (GO:0007413)3.31128165
65positive regulation of membrane potential (GO:0045838)3.30175567
66long-term memory (GO:0007616)3.28824424
67regulation of excitatory postsynaptic membrane potential (GO:0060079)3.28134719
68heterochromatin organization (GO:0070828)3.25909465
69neurotransmitter-gated ion channel clustering (GO:0072578)3.25878952
70regulation of synapse structural plasticity (GO:0051823)3.25534927
71social behavior (GO:0035176)3.24415997
72intraspecies interaction between organisms (GO:0051703)3.24415997
73diaphragm development (GO:0060539)3.24181834
74semaphorin-plexin signaling pathway (GO:0071526)3.23380556
75regulation of postsynaptic membrane potential (GO:0060078)3.19004368
76glycine transport (GO:0015816)3.17680593
77dendrite morphogenesis (GO:0048813)3.15463977
78acrosome assembly (GO:0001675)3.14831836
79transmission of nerve impulse (GO:0019226)3.14715883
80gamma-aminobutyric acid signaling pathway (GO:0007214)3.13959405
81cerebellar Purkinje cell layer development (GO:0021680)3.13254585
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.13036481
83regulation of neurotransmitter secretion (GO:0046928)3.12931260
84auditory behavior (GO:0031223)3.12923840
85prepulse inhibition (GO:0060134)3.11327192
86regulation of chromatin binding (GO:0035561)3.09794573
87cytoskeletal anchoring at plasma membrane (GO:0007016)3.08998779
88cell migration in hindbrain (GO:0021535)3.08311922
89mating behavior (GO:0007617)3.08122514
90response to auditory stimulus (GO:0010996)3.07548479
91regulation of vesicle fusion (GO:0031338)3.07275908
92synapse assembly (GO:0007416)3.06502716
93glucose 6-phosphate metabolic process (GO:0051156)3.06226191
94protein retention in ER lumen (GO:0006621)3.05391148
95regulation of synaptic transmission, glutamatergic (GO:0051966)3.04694994
96synapse organization (GO:0050808)3.03679499
97convergent extension (GO:0060026)3.02563913
98membrane depolarization (GO:0051899)3.02462258
99protein-DNA complex disassembly (GO:0032986)3.01511367
100nucleosome disassembly (GO:0006337)3.01511367
101nucleobase catabolic process (GO:0046113)3.01110844
102neuromuscular process controlling balance (GO:0050885)2.98482795
103neuronal ion channel clustering (GO:0045161)2.97912511
104negative regulation of inclusion body assembly (GO:0090084)2.97348829
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96872399
106positive regulation of synapse assembly (GO:0051965)2.96811821
107positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94854812
108response to pheromone (GO:0019236)2.94336757
109regulation of axon extension involved in axon guidance (GO:0048841)2.92871301
110behavioral response to cocaine (GO:0048148)2.91326772
111adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.89486746
112learning (GO:0007612)2.89259468
113maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.89000743
114establishment or maintenance of monopolar cell polarity (GO:0061339)2.88051916
115establishment of monopolar cell polarity (GO:0061162)2.88051916
116negative regulation of microtubule polymerization (GO:0031115)2.87598421
117vesicle transport along microtubule (GO:0047496)2.86587646
118neuron projection extension (GO:1990138)2.85749830
119regulation of neurotransmitter transport (GO:0051588)2.84346830
120regulation of synaptic plasticity (GO:0048167)2.82746478
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.82594281
122dendritic spine organization (GO:0097061)2.81942030
123G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.80894283
124establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.80823680
125regulation of axon guidance (GO:1902667)2.80166290
126regulation of microtubule-based movement (GO:0060632)2.79851002
127positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.79373762
128spinal cord development (GO:0021510)2.79148167
129regulation of dendritic spine morphogenesis (GO:0061001)2.77551073
130membrane hyperpolarization (GO:0060081)2.77107585
131piRNA metabolic process (GO:0034587)2.76955127
132positive regulation of dendritic spine morphogenesis (GO:0061003)2.76953216
133regulation of clathrin-mediated endocytosis (GO:2000369)2.76261003
134neural tube development (GO:0021915)2.75860668
135stress granule assembly (GO:0034063)2.75563193
136cochlea morphogenesis (GO:0090103)2.75455591
137collecting duct development (GO:0072044)2.74158892
138epithelial cell-cell adhesion (GO:0090136)2.74158194
139camera-type eye morphogenesis (GO:0048593)2.74074980
140establishment or maintenance of apical/basal cell polarity (GO:0035088)2.71453515
141establishment or maintenance of bipolar cell polarity (GO:0061245)2.71453515
142apical protein localization (GO:0045176)2.70811705
143dopamine receptor signaling pathway (GO:0007212)2.70484603
144positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.65978373
145positive regulation of cell cycle G2/M phase transition (GO:1902751)2.65978373
146dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.64309315
147RNA localization (GO:0006403)2.64305536
148presynaptic membrane organization (GO:0097090)2.60665550
149peptidyl-arginine methylation (GO:0018216)2.60382434
150peptidyl-arginine N-methylation (GO:0035246)2.60382434
151protein localization to microtubule (GO:0035372)2.60329052
152Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.56909331
153negative regulation of catenin import into nucleus (GO:0035414)2.55051993
154presynaptic membrane assembly (GO:0097105)2.54755149
155peptidyl-arginine omega-N-methylation (GO:0035247)2.51245993
156regulation of early endosome to late endosome transport (GO:2000641)2.49010608
157embryonic body morphogenesis (GO:0010172)2.48568415
158dendrite development (GO:0016358)2.46920881
159body morphogenesis (GO:0010171)2.45536083
160cellular component maintenance (GO:0043954)2.43518804
161DNA unwinding involved in DNA replication (GO:0006268)2.43448953
162establishment of apical/basal cell polarity (GO:0035089)2.42064366
163asymmetric protein localization (GO:0008105)2.41612737
164glucocorticoid receptor signaling pathway (GO:0042921)2.41534005
165negative regulation of histone methylation (GO:0031061)2.40243074
166regulation of establishment of planar polarity (GO:0090175)2.39015504
167embryonic retina morphogenesis in camera-type eye (GO:0060059)2.38826756
168regulation of mammary gland epithelial cell proliferation (GO:0033599)2.37042752
169regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.36252630
170central nervous system projection neuron axonogenesis (GO:0021952)2.35401930
171developmental cell growth (GO:0048588)2.34988307
172positive regulation of axon extension (GO:0045773)2.34881011
173ephrin receptor signaling pathway (GO:0048013)2.32737452
174regulation of RNA export from nucleus (GO:0046831)2.30846471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.56783790
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.85208196
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.90038862
4REST_21632747_ChIP-Seq_MESCs_Mouse2.88374188
5GBX2_23144817_ChIP-Seq_PC3_Human2.68924118
6ZNF263_19887448_ChIP-Seq_K562_Human2.65514396
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57995013
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56848952
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55637518
10* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.55075236
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.52640044
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39055565
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.37603272
14DROSHA_22980978_ChIP-Seq_HELA_Human2.37127619
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32526034
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27855129
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27855129
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25281928
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23484401
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23329237
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.22270385
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.18533213
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.17492414
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16398061
25* LXR_22292898_ChIP-Seq_THP-1_Human2.16277967
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.15165963
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10099568
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.09250039
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07770707
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.06704868
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06124933
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02636868
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01835737
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.97142547
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88004110
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85054106
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82211892
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.81181555
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80044393
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76926824
41ZNF274_21170338_ChIP-Seq_K562_Hela1.76167107
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.74875142
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.70637486
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67545422
45RACK7_27058665_Chip-Seq_MCF-7_Human1.66272781
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66036759
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65928256
48TAF15_26573619_Chip-Seq_HEK293_Human1.61288317
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60334301
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.58830549
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58600620
52* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57957751
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57531661
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56080360
55KDM2B_26808549_Chip-Seq_DND41_Human1.55490465
56MYC_22102868_ChIP-Seq_BL_Human1.52037922
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50083704
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49283181
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48587257
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45944535
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.44957518
62CREB1_26743006_Chip-Seq_LNCaP_Human1.44716104
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44602177
64VDR_21846776_ChIP-Seq_THP-1_Human1.41447565
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39885457
66SMAD4_21799915_ChIP-Seq_A2780_Human1.38964407
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38220807
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.36879176
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34892024
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.34702321
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33971250
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.32800086
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.32482865
74* KDM2B_26808549_Chip-Seq_JURKAT_Human1.32047020
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31261537
76P68_20966046_ChIP-Seq_HELA_Human1.30673208
77E2F7_22180533_ChIP-Seq_HELA_Human1.29382260
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.29124574
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28063964
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28004324
81MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25977159
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25408761
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23084614
84SMC4_20622854_ChIP-Seq_HELA_Human1.21787939
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20787355
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20318743
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18963503
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17928969
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.17688091
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17526466
91NCOR1_26117541_ChIP-Seq_K562_Human1.17500097
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.17427378
93RNF2_27304074_Chip-Seq_NSC_Mouse1.17155751
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17135328
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16875778
96AR_21572438_ChIP-Seq_LNCaP_Human1.15088365
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14717967
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.13707989
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13644859
100TCF7_22412390_ChIP-Seq_EML_Mouse1.13570976
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12579130
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.12152016
103AR_25329375_ChIP-Seq_VCAP_Human1.09815032
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07975939
105TP53_22127205_ChIP-Seq_IMR90_Human1.07936294
106* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07833165
107* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07625607
108HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06012548
109STAT3_23295773_ChIP-Seq_U87_Human1.05638928
110POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04908081
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04842614
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03801384
113XRN2_22483619_ChIP-Seq_HELA_Human1.03185355
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02829030
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02829030
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02723088
117* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02471410
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02339518
119AR_19668381_ChIP-Seq_PC3_Human1.02246246
120RING1B_27294783_Chip-Seq_NPCs_Mouse1.01175312
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00827433
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00026562
123TCF4_23295773_ChIP-Seq_U87_Human0.98327488
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97728009
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95884176
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.95632238
127ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95296379
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94516784
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94088635
130ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93992113
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93659523
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93557581
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92244440
134CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92047634
135CTCF_27219007_Chip-Seq_Bcells_Human0.90453260
136KDM2B_26808549_Chip-Seq_K562_Human0.89811863
137ER_23166858_ChIP-Seq_MCF-7_Human0.89693084
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89287590
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89112181
140RUNX2_22187159_ChIP-Seq_PCA_Human0.86977335
141P300_19829295_ChIP-Seq_ESCs_Human0.86743179
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86567347
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.86407067
144AHR_22903824_ChIP-Seq_MCF-7_Human0.86276501
145* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85363765
146* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85079796
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84453511
148KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83290634
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82751239
150SMAD4_21741376_ChIP-Seq_EPCs_Human0.82591526
151PIAS1_25552417_ChIP-Seq_VCAP_Human0.81442135
152ARNT_22903824_ChIP-Seq_MCF-7_Human0.81027963
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80427452
154AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80183697
155TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79958574
156TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79544870
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.79248177
158IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78856101
159CBP_20019798_ChIP-Seq_JUKART_Human0.78856101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.40204694
2MP0003880_abnormal_central_pattern4.63986912
3MP0003635_abnormal_synaptic_transmissio3.98560681
4MP0005423_abnormal_somatic_nervous3.62264542
5MP0005410_abnormal_fertilization3.52292416
6MP0009046_muscle_twitch3.43757646
7MP0004270_analgesia3.28053094
8MP0009745_abnormal_behavioral_response3.20285420
9MP0000566_synostosis3.10713618
10MP0002063_abnormal_learning/memory/cond3.04844114
11MP0002064_seizures3.01293583
12MP0001968_abnormal_touch/_nociception2.66279435
13MP0002572_abnormal_emotion/affect_behav2.61316785
14MP0000537_abnormal_urethra_morphology2.60175184
15MP0002734_abnormal_mechanical_nocicepti2.54470003
16MP0001486_abnormal_startle_reflex2.52686259
17MP0002272_abnormal_nervous_system2.45270118
18MP0001501_abnormal_sleep_pattern2.34824324
19MP0002909_abnormal_adrenal_gland2.30983079
20MP0003787_abnormal_imprinting2.21562788
21MP0006276_abnormal_autonomic_nervous2.19651798
22MP0005257_abnormal_intraocular_pressure2.16322696
23MP0005076_abnormal_cell_differentiation2.06222000
24MP0001440_abnormal_grooming_behavior2.04363326
25MP0002184_abnormal_innervation2.02090597
26MP0002736_abnormal_nociception_after2.00483288
27MP0002877_abnormal_melanocyte_morpholog1.97645882
28MP0002733_abnormal_thermal_nociception1.88890763
29MP0003942_abnormal_urinary_system1.87163154
30MP0002067_abnormal_sensory_capabilities1.85371917
31MP0002557_abnormal_social/conspecific_i1.80885555
32MP0003329_amyloid_beta_deposits1.79721988
33MP0005409_darkened_coat_color1.79561068
34MP0001970_abnormal_pain_threshold1.78258240
35MP0010234_abnormal_vibrissa_follicle1.76430049
36MP0003705_abnormal_hypodermis_morpholog1.74859185
37MP0000778_abnormal_nervous_system1.73907932
38MP0003879_abnormal_hair_cell1.72169710
39MP0003122_maternal_imprinting1.69999399
40MP0010030_abnormal_orbit_morphology1.69785022
41MP0003698_abnormal_male_reproductive1.68733565
42MP0001984_abnormal_olfaction1.66464432
43MP0004811_abnormal_neuron_physiology1.65161654
44MP0008569_lethality_at_weaning1.57814918
45MP0005645_abnormal_hypothalamus_physiol1.56380897
46MP0004924_abnormal_behavior1.53983337
47MP0005386_behavior/neurological_phenoty1.53983337
48MP0000678_abnormal_parathyroid_gland1.53472972
49MP0002735_abnormal_chemical_nociception1.53137643
50MP0004858_abnormal_nervous_system1.50750388
51MP0000579_abnormal_nail_morphology1.48167552
52MP0000955_abnormal_spinal_cord1.47454353
53MP0009780_abnormal_chondrocyte_physiolo1.45596527
54MP0003119_abnormal_digestive_system1.42666910
55MP0004885_abnormal_endolymph1.41791603
56MP0002882_abnormal_neuron_morphology1.41547464
57MP0008877_abnormal_DNA_methylation1.40552389
58* MP0002066_abnormal_motor_capabilities/c1.40443626
59MP0003385_abnormal_body_wall1.38192534
60MP0001348_abnormal_lacrimal_gland1.33951557
61MP0002249_abnormal_larynx_morphology1.33494043
62MP0004133_heterotaxia1.30704130
63MP0010386_abnormal_urinary_bladder1.29717028
64MP0003890_abnormal_embryonic-extraembry1.27123606
65MP0002653_abnormal_ependyma_morphology1.25086418
66MP0002152_abnormal_brain_morphology1.24747752
67MP0003315_abnormal_perineum_morphology1.23868948
68MP0005646_abnormal_pituitary_gland1.23621275
69MP0002697_abnormal_eye_size1.22795566
70MP0000751_myopathy1.19057904
71MP0003283_abnormal_digestive_organ1.18865600
72MP0005623_abnormal_meninges_morphology1.17546861
73MP0001849_ear_inflammation1.17452585
74MP0004142_abnormal_muscle_tone1.15587192
75MP0002822_catalepsy1.15585320
76MP0001502_abnormal_circadian_rhythm1.14635806
77MP0001905_abnormal_dopamine_level1.13778404
78MP0001529_abnormal_vocalization1.12821345
79MP0002081_perinatal_lethality1.10807882
80MP0001929_abnormal_gametogenesis1.06977487
81MP0003115_abnormal_respiratory_system1.06868544
82MP0000569_abnormal_digit_pigmentation1.05556966
83MP0009672_abnormal_birth_weight1.04985826
84MP0005187_abnormal_penis_morphology1.04690357
85MP0002089_abnormal_postnatal_growth/wei1.03092277
86MP0004185_abnormal_adipocyte_glucose1.02985579
87MP0004957_abnormal_blastocyst_morpholog1.02286447
88MP0002085_abnormal_embryonic_tissue1.02173587
89MP0003937_abnormal_limbs/digits/tail_de1.02163622
90MP0009278_abnormal_bone_marrow1.01708616
91MP0004272_abnormal_basement_membrane0.97750830
92MP0008961_abnormal_basal_metabolism0.96010687
93MP0000049_abnormal_middle_ear0.93200259
94MP0004742_abnormal_vestibular_system0.92402605
95MP0002116_abnormal_craniofacial_bone0.91994534
96MP0009053_abnormal_anal_canal0.91598897
97MP0002229_neurodegeneration0.91386342
98MP0002161_abnormal_fertility/fecundity0.91358124
99MP0008770_decreased_survivor_rate0.91318987
100MP0003938_abnormal_ear_development0.90350045
101MP0002069_abnormal_eating/drinking_beha0.89848488
102MP0000428_abnormal_craniofacial_morphol0.89716811
103MP0004145_abnormal_muscle_electrophysio0.88586409
104MP0003935_abnormal_craniofacial_develop0.88525478
105MP0004085_abnormal_heartbeat0.88387063
106MP0003123_paternal_imprinting0.88000076
107MP0003121_genomic_imprinting0.87517144
108MP0001730_embryonic_growth_arrest0.87112375
109MP0003136_yellow_coat_color0.85932079
110MP0002084_abnormal_developmental_patter0.85883035
111MP0003111_abnormal_nucleus_morphology0.85794191
112MP0005501_abnormal_skin_physiology0.85626529
113MP0003303_peritoneal_inflammation0.85353080
114MP0005551_abnormal_eye_electrophysiolog0.85049796
115MP0003633_abnormal_nervous_system0.84882022
116MP0005670_abnormal_white_adipose0.84045945
117MP0002752_abnormal_somatic_nervous0.82859680
118MP0005499_abnormal_olfactory_system0.82151381
119MP0005394_taste/olfaction_phenotype0.82151381
120MP0001177_atelectasis0.82115884
121MP0001188_hyperpigmentation0.81706293
122MP0002111_abnormal_tail_morphology0.80950854
123MP0000013_abnormal_adipose_tissue0.80191357
124MP0003631_nervous_system_phenotype0.78185532
125MP0005380_embryogenesis_phenotype0.77954484
126MP0001672_abnormal_embryogenesis/_devel0.77954484
127MP0003861_abnormal_nervous_system0.76669620
128MP0004197_abnormal_fetal_growth/weight/0.76566057
129MP0000631_abnormal_neuroendocrine_gland0.76453077
130MP0008932_abnormal_embryonic_tissue0.75606044
131MP0003755_abnormal_palate_morphology0.75534395
132MP0002114_abnormal_axial_skeleton0.75507996
133MP0003634_abnormal_glial_cell0.75038388
134MP0008438_abnormal_cutaneous_collagen0.74604424
135MP0002080_prenatal_lethality0.74572858
136MP0008872_abnormal_physiological_respon0.73315090
137MP0004233_abnormal_muscle_weight0.71365591
138MP0000462_abnormal_digestive_system0.68201561
139MP0001664_abnormal_digestion0.67044859
140MP0003646_muscle_fatigue0.66585616
141MP0001963_abnormal_hearing_physiology0.66044771
142MP0001299_abnormal_eye_distance/0.64286203
143MP0002210_abnormal_sex_determination0.64202992
144MP0000920_abnormal_myelination0.63972112
145MP0010769_abnormal_survival0.62242584
146MP0003632_abnormal_nervous_system0.61779273
147MP0000604_amyloidosis0.61744623
148MP0010770_preweaning_lethality0.60794331
149MP0002082_postnatal_lethality0.60794331
150MP0000534_abnormal_ureter_morphology0.60500079
151MP0010768_mortality/aging0.58981287
152MP0005535_abnormal_body_temperature0.58945651
153MP0005248_abnormal_Harderian_gland0.58621117
154MP0003137_abnormal_impulse_conducting0.57262354
155MP0002234_abnormal_pharynx_morphology0.56625874

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.07970888
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.54667189
3Absent/shortened dynein arms (HP:0200106)5.54667189
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.54382526
5Visual hallucinations (HP:0002367)4.72562992
6Focal seizures (HP:0007359)4.69182140
7Myokymia (HP:0002411)4.40806499
8Abnormal respiratory motile cilium physiology (HP:0012261)4.36758113
9Hyperacusis (HP:0010780)4.26093668
10Abnormal respiratory motile cilium morphology (HP:0005938)3.96092947
11Abnormal respiratory epithelium morphology (HP:0012253)3.96092947
12Mutism (HP:0002300)3.84814939
13Progressive cerebellar ataxia (HP:0002073)3.69346441
14Rhinitis (HP:0012384)3.64495324
15Atonic seizures (HP:0010819)3.63246241
16Epileptic encephalopathy (HP:0200134)3.59203109
17Supranuclear gaze palsy (HP:0000605)3.53416098
18Abnormal ciliary motility (HP:0012262)3.44714859
19Febrile seizures (HP:0002373)3.37015063
20Absence seizures (HP:0002121)3.25583213
21Ankle clonus (HP:0011448)3.16626671
22Truncus arteriosus (HP:0001660)3.13675566
23Overriding aorta (HP:0002623)3.13256760
24Elfin facies (HP:0004428)3.07926241
25Generalized tonic-clonic seizures (HP:0002069)3.03036704
26Infertility (HP:0000789)3.00999095
27Cortical dysplasia (HP:0002539)2.97252151
28Amyotrophic lateral sclerosis (HP:0007354)2.96446555
29Turricephaly (HP:0000262)2.92794119
30Dialeptic seizures (HP:0011146)2.92214958
31Limb dystonia (HP:0002451)2.92053330
32Abnormality of the lower motor neuron (HP:0002366)2.81993769
33Upper limb amyotrophy (HP:0009129)2.77497099
34Distal upper limb amyotrophy (HP:0007149)2.77497099
35Urinary bladder sphincter dysfunction (HP:0002839)2.74809864
36Postural instability (HP:0002172)2.74635357
37Action tremor (HP:0002345)2.73026851
38Abnormal eating behavior (HP:0100738)2.69587921
39Genetic anticipation (HP:0003743)2.65163940
40Ventricular fibrillation (HP:0001663)2.64478831
41Polyphagia (HP:0002591)2.64370461
42Morphological abnormality of the middle ear (HP:0008609)2.64200491
43Chronic bronchitis (HP:0004469)2.63286355
44Neoplasm of the adrenal cortex (HP:0100641)2.62961634
45Impaired vibration sensation in the lower limbs (HP:0002166)2.62917343
46Flat cornea (HP:0007720)2.62542884
47Hemiparesis (HP:0001269)2.61877328
48Drooling (HP:0002307)2.57361191
49Excessive salivation (HP:0003781)2.57361191
50Broad-based gait (HP:0002136)2.56983027
51Increased nuchal translucency (HP:0010880)2.55021341
52Premature rupture of membranes (HP:0001788)2.53791228
53Patellar dislocation (HP:0002999)2.53481868
54Progressive inability to walk (HP:0002505)2.51724659
55Neurofibrillary tangles (HP:0002185)2.51110417
56Renovascular hypertension (HP:0100817)2.50579319
57Cerebral inclusion bodies (HP:0100314)2.49796736
58Aplasia involving bones of the upper limbs (HP:0009823)2.48761801
59Aplasia of the phalanges of the hand (HP:0009802)2.48761801
60Aplasia involving bones of the extremities (HP:0009825)2.48761801
61Reticulocytosis (HP:0001923)2.44497676
62Depression (HP:0000716)2.42614019
63Ulnar bowing (HP:0003031)2.41492262
64Lower limb amyotrophy (HP:0007210)2.41462976
65Bladder diverticulum (HP:0000015)2.41230739
66Renal duplication (HP:0000075)2.41206429
67Gaze-evoked nystagmus (HP:0000640)2.41177153
68Genu recurvatum (HP:0002816)2.38304983
69Protrusio acetabuli (HP:0003179)2.36634569
70Blue irides (HP:0000635)2.34826403
71Hand muscle atrophy (HP:0009130)2.30800698
72Fragile skin (HP:0001030)2.30453109
73Hemiplegia (HP:0002301)2.30425639
74Bundle branch block (HP:0011710)2.30021042
75Abnormality of the corticospinal tract (HP:0002492)2.29842296
76Urinary urgency (HP:0000012)2.28441187
77Long palpebral fissure (HP:0000637)2.27679743
78Hammertoe (HP:0001765)2.26212489
79Truncal ataxia (HP:0002078)2.24516533
80Abnormality of dentin (HP:0010299)2.24228680
81Shallow orbits (HP:0000586)2.23881321
82Spastic gait (HP:0002064)2.23119536
83High anterior hairline (HP:0009890)2.22888830
84Hypoplasia of the brainstem (HP:0002365)2.20969415
85Aplasia/Hypoplasia of the brainstem (HP:0007362)2.20969415
86Atelectasis (HP:0100750)2.19503909
87Dysdiadochokinesis (HP:0002075)2.19189185
88Dysmetria (HP:0001310)2.18702444
89Amblyopia (HP:0000646)2.18305696
90Pointed chin (HP:0000307)2.17970694
91Atrophic scars (HP:0001075)2.17809637
92Bradykinesia (HP:0002067)2.16253209
93Abnormal large intestine physiology (HP:0012700)2.16238267
94Distal lower limb amyotrophy (HP:0008944)2.14961087
95Obsessive-compulsive behavior (HP:0000722)2.14349363
96Hyperthyroidism (HP:0000836)2.14071116
97Torticollis (HP:0000473)2.13669047
98Poor eye contact (HP:0000817)2.12490542
99Anxiety (HP:0000739)2.12291268
100Abnormality of the aortic arch (HP:0012303)2.11801682
101Curly hair (HP:0002212)2.11574001
102Insomnia (HP:0100785)2.11200751
103Impaired social interactions (HP:0000735)2.09732550
104Abnormal social behavior (HP:0012433)2.09732550
105Shawl scrotum (HP:0000049)2.09270427
106Status epilepticus (HP:0002133)2.07176105
107Inappropriate behavior (HP:0000719)2.04816335
108Papilledema (HP:0001085)2.03402012
109Lower limb muscle weakness (HP:0007340)2.00198017
110Bronchomalacia (HP:0002780)1.99483972
111Hyperventilation (HP:0002883)1.97818501
112Attention deficit hyperactivity disorder (HP:0007018)1.96150678
113Bowel diverticulosis (HP:0005222)1.95528013
114Generalized hypotonia (HP:0001290)1.95057943
115Abnormality of ocular smooth pursuit (HP:0000617)1.94666179
116Impaired smooth pursuit (HP:0007772)1.94500240
117Wide intermamillary distance (HP:0006610)1.93900078
118Coronal craniosynostosis (HP:0004440)1.93898038
119Bell-shaped thorax (HP:0001591)1.93586160
120Abnormal gallbladder physiology (HP:0012438)1.92968571
121Cholecystitis (HP:0001082)1.92968571
122Neuronal loss in central nervous system (HP:0002529)1.92846571
123Male infertility (HP:0003251)1.92372082
124Spastic tetraparesis (HP:0001285)1.89888170
125Abnormality of binocular vision (HP:0011514)1.89539085
126Diplopia (HP:0000651)1.89539085
127Agitation (HP:0000713)1.89265727
128Delusions (HP:0000746)1.88747057
129Arnold-Chiari malformation (HP:0002308)1.88044507
130Megalocornea (HP:0000485)1.87137074
131Fetal akinesia sequence (HP:0001989)1.85927781
132Disproportionate tall stature (HP:0001519)1.82982925
133Inability to walk (HP:0002540)1.81810998
134Vertebral arch anomaly (HP:0008438)1.81583850
135Heterotopia (HP:0002282)1.81318040
136Bowel incontinence (HP:0002607)1.81191977
137Termporal pattern (HP:0011008)1.80389479
138Insidious onset (HP:0003587)1.80389479
139Protruding tongue (HP:0010808)1.80320891
140Absent speech (HP:0001344)1.79720400
141Focal dystonia (HP:0004373)1.79173017
142Morphological abnormality of the pyramidal tract (HP:0002062)1.78987877
143Hepatoblastoma (HP:0002884)1.78936618
144Spina bifida occulta (HP:0003298)1.78036453
145Papillary thyroid carcinoma (HP:0002895)1.76055905
146Gait imbalance (HP:0002141)1.75639772
147Ankyloglossia (HP:0010296)1.73097545
148Astrocytoma (HP:0009592)1.72995005
149Abnormality of the astrocytes (HP:0100707)1.72995005
150Lissencephaly (HP:0001339)1.72340734
151Urethral obstruction (HP:0000796)1.72005742
152Exotropia (HP:0000577)1.71768778
153Hypercalcemia (HP:0003072)1.70964864
154Abnormal number of incisors (HP:0011064)1.70902296
155Failure to thrive in infancy (HP:0001531)1.68230989
156Intention tremor (HP:0002080)1.67832256
157Sacral dimple (HP:0000960)1.66973385
158Proximal placement of thumb (HP:0009623)1.66365612
159Abnormality of reticulocytes (HP:0004312)1.65698186
160Deviation of the thumb (HP:0009603)1.64691115
161Dysmetric saccades (HP:0000641)1.62107629
162Decreased motor nerve conduction velocity (HP:0003431)1.61978440
163Achilles tendon contracture (HP:0001771)1.61687417
164Hypoventilation (HP:0002791)1.61441796
165Cheekbone underdevelopment (HP:0010669)1.60496862
166Calcaneovalgus deformity (HP:0001848)1.60384516
167Trigonocephaly (HP:0000243)1.57787038
168Precocious puberty (HP:0000826)1.57767338
169Focal segmental glomerulosclerosis (HP:0000097)1.56246222
170Neonatal short-limb short stature (HP:0008921)1.54656597
171Biconcave vertebral bodies (HP:0004586)1.53832227
172Hypercalciuria (HP:0002150)1.51806342
173Difficulty climbing stairs (HP:0003551)1.51291252
174Breech presentation (HP:0001623)1.50562676
175Hypoparathyroidism (HP:0000829)1.50306026
176Mitral regurgitation (HP:0001653)1.50100436
177Adducted thumb (HP:0001181)1.49944412
178Polycystic kidney dysplasia (HP:0000113)1.49427158
179Peripheral hypomyelination (HP:0007182)1.48716232
180Premature skin wrinkling (HP:0100678)1.47293407
181Abnormality of the calcaneus (HP:0008364)1.46880542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.37850886
2NTRK34.09593180
3MARK13.93083781
4SIK13.56377741
5MST1R3.47447276
6MAP3K93.44718931
7EPHA23.14317348
8CDK123.10905882
9PRKD33.04076642
10TRIB32.71629225
11PNCK2.70952520
12MAP3K42.68944801
13EEF2K2.58312792
14NTRK22.49836737
15MINK12.49182038
16EPHB22.39039586
17PDK32.26608678
18PDK42.26608678
19MAP2K72.11894760
20EPHA42.09995862
21PAK62.05661192
22STK381.95696945
23IRAK31.94944182
24LATS21.92775980
25MET1.82558960
26SIK21.76982971
27NTRK11.63991276
28CASK1.61794167
29MAP3K121.60915243
30DAPK21.60369032
31MAPK131.59514416
32MAP2K41.59177785
33CSNK1G21.48852613
34CAMKK11.39013561
35MAP3K101.37930733
36SMG11.37471735
37PDK21.29194339
38CDK51.28848389
39RIPK11.25362683
40CSNK1G31.24801392
41GRK51.23946434
42KSR21.22663067
43TESK11.20709437
44MTOR1.19911995
45PINK11.18992990
46PHKG21.13936241
47PHKG11.13936241
48PRKCG1.13561880
49CSNK1A1L1.13007214
50PDGFRA1.12910693
51PLK21.10951178
52UHMK11.10703943
53CAMK1D1.09447267
54BMX1.08529899
55RIPK41.08384741
56NEK21.06716386
57TYRO31.06499886
58STK391.02675035
59PTK21.01873848
60PKN21.00775762
61ALK0.99942869
62WNK40.96748329
63LMTK20.96133544
64STK110.95848086
65PAK40.95519933
66DYRK30.94134742
67TAOK10.92746903
68TNIK0.92307314
69RPS6KA20.87068166
70KSR10.86464026
71RPS6KA40.85690244
72AKT30.85390307
73PTK60.85020611
74CAMK2A0.82942487
75CLK10.81234915
76CDK150.80759751
77CDK140.80337025
78CSNK1G10.80224639
79PAK30.80136262
80CDK180.78068187
81PRKG20.77113076
82BRD40.74781210
83CAMK1G0.73084196
84WNK10.72674980
85DAPK10.72019919
86FES0.70190702
87ARAF0.69088773
88CDK11A0.68161497
89IRAK20.67875328
90TTK0.66288849
91DYRK1A0.66024269
92PRKCH0.65015436
93PTK2B0.64987890
94MAP3K20.62027108
95MAP3K80.61156303
96CAMK10.61028508
97BRSK10.60859232
98MARK20.59868788
99CAMK2B0.59504958
100BUB10.57405133
101MAP3K60.55877124
102CDK190.52861589
103PRKCZ0.52138831
104MUSK0.51277279
105MAP3K10.51060308
106BCR0.50856651
107LATS10.49596574
108CHEK20.49308061
109PDK10.49102498
110CDK10.48348188
111CAMKK20.48119197
112RET0.47187970
113CDC42BPA0.47181341
114TNK20.46773240
115CDC70.46603356
116GSK3B0.46373471
117PKN10.44953287
118DYRK20.44886991
119CDK20.44453570
120BRAF0.43859787
121MAPK80.43205558
122CDK70.42845267
123NME10.42732326
124MAPK100.42575170
125* RPS6KA30.42403727
126CAMK2G0.41584514
127SGK4940.41126952
128SGK2230.41126952
129WNK30.39861425
130PRKCI0.39464146
131GRK70.39327625
132SGK10.39025284
133CHEK10.39024817
134DDR20.38937453
135CSNK1E0.38467160
136AURKA0.38111818
137RPS6KA10.37781551
138NME20.37342712
139PDPK10.37216249
140AKT20.36357543
141MAPK140.35201607
142CAMK2D0.34878419
143EPHB10.34114458
144CCNB10.33631156
145CDK90.33385345
146SGK30.33101754
147PRKCE0.32567348
148FYN0.32476706
149ERBB40.31346865
150PRKCB0.30943582
151OXSR10.30733795
152DMPK0.29380822
153PRKAA10.28435774

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.97229066
2* Nicotine addiction_Homo sapiens_hsa050333.81535304
3Synaptic vesicle cycle_Homo sapiens_hsa047213.59496470
4GABAergic synapse_Homo sapiens_hsa047272.79474334
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41491513
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38981364
7* Circadian entrainment_Homo sapiens_hsa047132.29931802
8Olfactory transduction_Homo sapiens_hsa047402.29830802
9* Amphetamine addiction_Homo sapiens_hsa050312.28892835
10* Glutamatergic synapse_Homo sapiens_hsa047242.28177661
11* Long-term potentiation_Homo sapiens_hsa047202.26266387
12Morphine addiction_Homo sapiens_hsa050322.25925810
13Salivary secretion_Homo sapiens_hsa049702.12211228
14Taste transduction_Homo sapiens_hsa047422.10661037
15Dorso-ventral axis formation_Homo sapiens_hsa043202.04297380
16Dopaminergic synapse_Homo sapiens_hsa047281.93464739
17Insulin secretion_Homo sapiens_hsa049111.91585983
18Gastric acid secretion_Homo sapiens_hsa049711.90541773
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.80146407
20Cholinergic synapse_Homo sapiens_hsa047251.64108741
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63104843
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62229230
23Collecting duct acid secretion_Homo sapiens_hsa049661.60915417
24Renin secretion_Homo sapiens_hsa049241.59112038
25GnRH signaling pathway_Homo sapiens_hsa049121.56693047
26Estrogen signaling pathway_Homo sapiens_hsa049151.56349837
27Notch signaling pathway_Homo sapiens_hsa043301.55820646
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53248031
29Gap junction_Homo sapiens_hsa045401.51167553
30Serotonergic synapse_Homo sapiens_hsa047261.51031444
31* Cocaine addiction_Homo sapiens_hsa050301.50524513
32Oxytocin signaling pathway_Homo sapiens_hsa049211.42045214
33* Calcium signaling pathway_Homo sapiens_hsa040201.40908346
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36298590
35Long-term depression_Homo sapiens_hsa047301.36078293
36Cardiac muscle contraction_Homo sapiens_hsa042601.34217760
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32735294
38Adherens junction_Homo sapiens_hsa045201.31775721
39Chronic myeloid leukemia_Homo sapiens_hsa052201.29133771
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28926554
41mRNA surveillance pathway_Homo sapiens_hsa030151.26581883
42Glioma_Homo sapiens_hsa052141.25338328
43Vitamin B6 metabolism_Homo sapiens_hsa007501.25072044
44ErbB signaling pathway_Homo sapiens_hsa040121.24831043
45Fructose and mannose metabolism_Homo sapiens_hsa000511.24005540
46Axon guidance_Homo sapiens_hsa043601.22982506
47Biosynthesis of amino acids_Homo sapiens_hsa012301.20369265
48Oocyte meiosis_Homo sapiens_hsa041141.18696348
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16656512
50Type II diabetes mellitus_Homo sapiens_hsa049301.16456999
51Endometrial cancer_Homo sapiens_hsa052131.08320796
52* cAMP signaling pathway_Homo sapiens_hsa040241.07881937
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06780770
54MicroRNAs in cancer_Homo sapiens_hsa052061.05756828
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04412501
56Galactose metabolism_Homo sapiens_hsa000521.03238443
57* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99402172
58Tight junction_Homo sapiens_hsa045300.97761423
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96530543
60Vibrio cholerae infection_Homo sapiens_hsa051100.91476449
61Bladder cancer_Homo sapiens_hsa052190.91298462
62Steroid biosynthesis_Homo sapiens_hsa001000.90255577
63AMPK signaling pathway_Homo sapiens_hsa041520.89769005
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89122766
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.88615818
66Melanogenesis_Homo sapiens_hsa049160.87712618
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.85288810
68ECM-receptor interaction_Homo sapiens_hsa045120.84309924
69Lysine degradation_Homo sapiens_hsa003100.84069736
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83333709
71Cell cycle_Homo sapiens_hsa041100.82430495
72Pentose phosphate pathway_Homo sapiens_hsa000300.82334113
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82145091
74RNA transport_Homo sapiens_hsa030130.82112775
75Focal adhesion_Homo sapiens_hsa045100.81363496
76MAPK signaling pathway_Homo sapiens_hsa040100.81309546
77Phototransduction_Homo sapiens_hsa047440.79243634
78Thyroid cancer_Homo sapiens_hsa052160.78651803
79Glucagon signaling pathway_Homo sapiens_hsa049220.76379184
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75157356
81Choline metabolism in cancer_Homo sapiens_hsa052310.73273521
82Renal cell carcinoma_Homo sapiens_hsa052110.72984453
83Pancreatic secretion_Homo sapiens_hsa049720.72816289
84Dilated cardiomyopathy_Homo sapiens_hsa054140.72602830
85Thyroid hormone synthesis_Homo sapiens_hsa049180.71724637
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71688430
87Pancreatic cancer_Homo sapiens_hsa052120.68919276
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67965861
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.67637492
90Spliceosome_Homo sapiens_hsa030400.65176627
91Type I diabetes mellitus_Homo sapiens_hsa049400.63889102
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63841010
93* Alcoholism_Homo sapiens_hsa050340.63695238
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63145642
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62761761
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62582659
97Wnt signaling pathway_Homo sapiens_hsa043100.62425625
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.61848125
99Sulfur relay system_Homo sapiens_hsa041220.60733678
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59291457
101Melanoma_Homo sapiens_hsa052180.58949193
102Pathways in cancer_Homo sapiens_hsa052000.58471865
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57473834
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57444320
105Inositol phosphate metabolism_Homo sapiens_hsa005620.56746319
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56746063
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56542449
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55820249
109Ras signaling pathway_Homo sapiens_hsa040140.55745527
110Insulin signaling pathway_Homo sapiens_hsa049100.55676697
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54449558
112Hedgehog signaling pathway_Homo sapiens_hsa043400.53310090
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53263174
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51849927
115Proteoglycans in cancer_Homo sapiens_hsa052050.50741346
116Non-small cell lung cancer_Homo sapiens_hsa052230.50290342
117Carbon metabolism_Homo sapiens_hsa012000.50158333
118Fatty acid biosynthesis_Homo sapiens_hsa000610.49328869
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47695942
120VEGF signaling pathway_Homo sapiens_hsa043700.46564938
121Endocytosis_Homo sapiens_hsa041440.46372085
122Rap1 signaling pathway_Homo sapiens_hsa040150.44258641
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44206733
124Prolactin signaling pathway_Homo sapiens_hsa049170.43894063
125Bile secretion_Homo sapiens_hsa049760.42209202
126Huntingtons disease_Homo sapiens_hsa050160.40977415
127mTOR signaling pathway_Homo sapiens_hsa041500.40653624
128Basal cell carcinoma_Homo sapiens_hsa052170.40102245
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36280193
130Colorectal cancer_Homo sapiens_hsa052100.36195572
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35663266
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35003218
133Alzheimers disease_Homo sapiens_hsa050100.34973987
134Butanoate metabolism_Homo sapiens_hsa006500.34302129
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31922572
136Prion diseases_Homo sapiens_hsa050200.29529881
137Hippo signaling pathway_Homo sapiens_hsa043900.27371842

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