GRIK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.98114224
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.90747353
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.82027429
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.73779370
5synaptic vesicle maturation (GO:0016188)5.68474166
6vocalization behavior (GO:0071625)5.60344145
7regulation of glutamate receptor signaling pathway (GO:1900449)5.25295877
8neuron cell-cell adhesion (GO:0007158)5.07659348
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.06054142
10synaptic vesicle exocytosis (GO:0016079)4.96368956
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.91710880
12pyrimidine nucleobase catabolic process (GO:0006208)4.85375246
13regulation of synaptic vesicle exocytosis (GO:2000300)4.76112353
14* ionotropic glutamate receptor signaling pathway (GO:0035235)4.72482020
15protein localization to synapse (GO:0035418)4.72223653
16glutamate secretion (GO:0014047)4.64634504
17exploration behavior (GO:0035640)4.52313956
18layer formation in cerebral cortex (GO:0021819)4.48959739
19dendritic spine morphogenesis (GO:0060997)4.48465774
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.37259965
21* synaptic transmission, glutamatergic (GO:0035249)4.32515702
22regulation of synapse structural plasticity (GO:0051823)4.28163877
23regulation of neuronal synaptic plasticity (GO:0048168)4.27059134
24regulation of synaptic vesicle transport (GO:1902803)4.19838890
25neurotransmitter secretion (GO:0007269)4.18509280
26* glutamate receptor signaling pathway (GO:0007215)4.13968380
27neuronal action potential propagation (GO:0019227)4.12376113
28gamma-aminobutyric acid transport (GO:0015812)4.12128611
29* neuron-neuron synaptic transmission (GO:0007270)4.09887920
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.09543044
31neurotransmitter-gated ion channel clustering (GO:0072578)4.05253222
32long-term memory (GO:0007616)3.98650981
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.92052325
34positive regulation of synaptic transmission, GABAergic (GO:0032230)3.86460679
35neuron recognition (GO:0008038)3.84349601
36auditory behavior (GO:0031223)3.83344676
37positive regulation of membrane potential (GO:0045838)3.83214029
38transmission of nerve impulse (GO:0019226)3.82364628
39nucleobase catabolic process (GO:0046113)3.81725402
40postsynaptic membrane organization (GO:0001941)3.76909987
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.75167278
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74653798
43proline transport (GO:0015824)3.72465898
44axonal fasciculation (GO:0007413)3.70735658
45prepulse inhibition (GO:0060134)3.70658804
46amino acid import (GO:0043090)3.66328799
47regulation of dendritic spine morphogenesis (GO:0061001)3.62878282
48regulation of postsynaptic membrane potential (GO:0060078)3.58594219
49response to auditory stimulus (GO:0010996)3.57415964
50dendrite morphogenesis (GO:0048813)3.56259062
51neuronal ion channel clustering (GO:0045161)3.55949110
52dermatan sulfate biosynthetic process (GO:0030208)3.54241256
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.52554611
54neuromuscular process controlling balance (GO:0050885)3.51483898
55establishment of mitochondrion localization (GO:0051654)3.51046413
56positive regulation of synapse maturation (GO:0090129)3.47379799
57regulation of respiratory system process (GO:0044065)3.44716661
58neurotransmitter transport (GO:0006836)3.44473945
59synaptic vesicle endocytosis (GO:0048488)3.42204496
60presynaptic membrane assembly (GO:0097105)3.41965657
61glycine transport (GO:0015816)3.41491856
62positive regulation of neurotransmitter secretion (GO:0001956)3.41464609
63regulation of neurotransmitter secretion (GO:0046928)3.41458845
64regulation of synaptic plasticity (GO:0048167)3.41131199
65cerebellar Purkinje cell differentiation (GO:0021702)3.41058911
66positive regulation of neurotransmitter transport (GO:0051590)3.40624142
67* regulation of synaptic transmission, glutamatergic (GO:0051966)3.36607632
68central nervous system myelination (GO:0022010)3.34775345
69axon ensheathment in central nervous system (GO:0032291)3.34775345
70cell migration in hindbrain (GO:0021535)3.33678803
71membrane hyperpolarization (GO:0060081)3.32661045
72dermatan sulfate metabolic process (GO:0030205)3.31755646
73long-term synaptic potentiation (GO:0060291)3.26685868
74presynaptic membrane organization (GO:0097090)3.25084937
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.24059613
76adult walking behavior (GO:0007628)3.23324502
77synapse assembly (GO:0007416)3.22431739
78regulation of neurotransmitter transport (GO:0051588)3.22356552
79central nervous system projection neuron axonogenesis (GO:0021952)3.22255581
80gamma-aminobutyric acid signaling pathway (GO:0007214)3.19995180
81positive regulation of synapse assembly (GO:0051965)3.19327639
82dendritic spine organization (GO:0097061)3.19270484
83L-amino acid import (GO:0043092)3.17780158
84negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16647411
85learning (GO:0007612)3.14407196
86regulation of neurotransmitter levels (GO:0001505)3.14287906
87cellular potassium ion homeostasis (GO:0030007)3.13160313
88membrane depolarization (GO:0051899)3.12979818
89negative regulation of dendrite development (GO:2000171)3.10739585
90regulation of synaptic transmission, GABAergic (GO:0032228)3.10715679
91positive regulation of dendritic spine development (GO:0060999)3.08684013
92mechanosensory behavior (GO:0007638)3.07350542
93positive regulation of dendritic spine morphogenesis (GO:0061003)3.05699031
94regulation of dendritic spine development (GO:0060998)3.04366677
95astrocyte differentiation (GO:0048708)3.04242294
96regulation of synapse maturation (GO:0090128)3.03883777
97oligodendrocyte differentiation (GO:0048709)3.00869614
98sodium ion export (GO:0071436)3.00806903
99membrane depolarization during action potential (GO:0086010)3.00549005
100regulation of vesicle fusion (GO:0031338)2.98588635
101G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96859028
102regulation of respiratory gaseous exchange (GO:0043576)2.96188780
103behavioral fear response (GO:0001662)2.95912736
104behavioral defense response (GO:0002209)2.95912736
105positive regulation of synaptic transmission (GO:0050806)2.95765235
106neuromuscular process (GO:0050905)2.94994291
107cerebellar granule cell differentiation (GO:0021707)2.94524094
108central nervous system neuron axonogenesis (GO:0021955)2.93250196
109synapse organization (GO:0050808)2.91952851
110neuromuscular process controlling posture (GO:0050884)2.89834320
111* regulation of synaptic transmission (GO:0050804)2.89489305
112* G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89246302
113activation of protein kinase A activity (GO:0034199)2.88223020
114startle response (GO:0001964)2.87960643
115adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.87916021
116* negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87764254
117establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.86693222
118mitochondrion transport along microtubule (GO:0047497)2.86693222
119ganglion development (GO:0061548)2.85942662
120cerebellar Purkinje cell layer development (GO:0021680)2.84820662
121negative regulation of axonogenesis (GO:0050771)2.83200522
122regulation of synapse assembly (GO:0051963)2.82129533
123neuromuscular synaptic transmission (GO:0007274)2.79781569
124chondroitin sulfate catabolic process (GO:0030207)2.79082760
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.74921338
126enteric nervous system development (GO:0048484)2.72518421
127regulation of axon extension involved in axon guidance (GO:0048841)2.69986324
128cerebral cortex radially oriented cell migration (GO:0021799)2.69816207
129regulation of synapse organization (GO:0050807)2.67390648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_22144423_ChIP-Seq_EOC_Human5.53578586
2* GBX2_23144817_ChIP-Seq_PC3_Human3.52237650
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14001387
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06886346
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92512007
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.76167226
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72709655
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72709655
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68782336
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.66895109
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.53431605
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51391614
13* DROSHA_22980978_ChIP-Seq_HELA_Human2.49688681
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49313138
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41445250
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36427214
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35080932
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.34851909
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.32654435
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27240731
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.25557823
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23519929
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22822043
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14864033
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.12550470
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06614150
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00038398
28AR_21572438_ChIP-Seq_LNCaP_Human1.97988533
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88535748
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78082192
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74494029
32* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65093163
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59462204
34SMAD4_21799915_ChIP-Seq_A2780_Human1.53633038
35TAF15_26573619_Chip-Seq_HEK293_Human1.51408473
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51222743
37* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46972988
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45712144
39* ERG_21242973_ChIP-ChIP_JURKAT_Human1.45004455
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.44363011
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44017992
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41313314
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.40047921
44* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36756604
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36314267
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36068944
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35817685
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.35759558
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.33158393
50P300_19829295_ChIP-Seq_ESCs_Human1.32506199
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30554578
52RNF2_27304074_Chip-Seq_NSC_Mouse1.29910123
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29614537
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29305158
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29203079
56* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25531187
57* STAT3_23295773_ChIP-Seq_U87_Human1.24242417
58* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22343055
59AR_19668381_ChIP-Seq_PC3_Human1.22138162
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17679869
61ZNF274_21170338_ChIP-Seq_K562_Hela1.16411532
62* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15000486
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14459050
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12845142
65AR_25329375_ChIP-Seq_VCAP_Human1.12576792
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.12433329
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.11707091
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11166082
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10578681
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10362611
71* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10105312
72* TCF4_23295773_ChIP-Seq_U87_Human1.08144956
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08097423
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.07780734
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07451373
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07063945
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06493924
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06493924
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06206127
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04976254
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.04784841
82IGF1R_20145208_ChIP-Seq_DFB_Human1.04778250
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04422400
84* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04126916
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02585718
86AHR_22903824_ChIP-Seq_MCF-7_Human1.01824612
87KDM2B_26808549_Chip-Seq_K562_Human1.00708473
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00656156
89FUS_26573619_Chip-Seq_HEK293_Human0.99943561
90* RUNX2_22187159_ChIP-Seq_PCA_Human0.99787017
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99576755
92* SMAD3_21741376_ChIP-Seq_HESCs_Human0.99431223
93ISL1_27105846_Chip-Seq_CPCs_Mouse0.99373455
94ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99331557
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.98459522
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98453579
97CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98306848
98GATA1_26923725_Chip-Seq_HPCs_Mouse0.97784159
99* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97072463
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96519245
101SOX9_26525672_Chip-Seq_HEART_Mouse0.95220915
102* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94680341
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94343857
104* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93376868
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92805446
106NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92466874
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91372170
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91182846
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90978175
110* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90069804
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89975022
112NANOG_18555785_Chip-Seq_ESCs_Mouse0.89590283
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89462841
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.89342012
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89227861
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89176307
117TP53_16413492_ChIP-PET_HCT116_Human0.88869073
118* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87994214
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87269193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.12697510
2MP0003880_abnormal_central_pattern4.35289380
3* MP0003635_abnormal_synaptic_transmissio3.96951586
4MP0004270_analgesia3.48440433
5MP0009745_abnormal_behavioral_response3.34077228
6MP0005423_abnormal_somatic_nervous3.33086460
7MP0002063_abnormal_learning/memory/cond3.23849487
8MP0009046_muscle_twitch3.16726848
9MP0002822_catalepsy3.09576093
10MP0002064_seizures3.05079576
11MP0001486_abnormal_startle_reflex2.84851304
12MP0001968_abnormal_touch/_nociception2.79811932
13MP0002572_abnormal_emotion/affect_behav2.79189502
14MP0002734_abnormal_mechanical_nocicepti2.51998222
15MP0002272_abnormal_nervous_system2.50065732
16MP0000778_abnormal_nervous_system2.14024004
17MP0002736_abnormal_nociception_after2.02473015
18MP0002735_abnormal_chemical_nociception2.00357982
19MP0005646_abnormal_pituitary_gland1.97976442
20MP0001440_abnormal_grooming_behavior1.95764704
21MP0001501_abnormal_sleep_pattern1.94090748
22MP0002733_abnormal_thermal_nociception1.93377616
23MP0002557_abnormal_social/conspecific_i1.93042715
24MP0002067_abnormal_sensory_capabilities1.92484572
25MP0002184_abnormal_innervation1.88463896
26MP0001970_abnormal_pain_threshold1.85413439
27MP0003787_abnormal_imprinting1.83465039
28MP0004858_abnormal_nervous_system1.82395606
29MP0005645_abnormal_hypothalamus_physiol1.81549600
30MP0008569_lethality_at_weaning1.79777864
31MP0004924_abnormal_behavior1.79403624
32MP0005386_behavior/neurological_phenoty1.79403624
33MP0004811_abnormal_neuron_physiology1.75880170
34MP0004885_abnormal_endolymph1.71531757
35MP0001984_abnormal_olfaction1.63845019
36MP0000955_abnormal_spinal_cord1.63632813
37MP0006292_abnormal_olfactory_placode1.61889471
38MP0009780_abnormal_chondrocyte_physiolo1.58106439
39MP0001188_hyperpigmentation1.50048624
40MP0002882_abnormal_neuron_morphology1.48760772
41MP0003879_abnormal_hair_cell1.48639722
42MP0001529_abnormal_vocalization1.48161505
43MP0006276_abnormal_autonomic_nervous1.42726281
44MP0004142_abnormal_muscle_tone1.41577958
45MP0002066_abnormal_motor_capabilities/c1.41254428
46MP0004742_abnormal_vestibular_system1.32154278
47MP0002909_abnormal_adrenal_gland1.28001127
48MP0000569_abnormal_digit_pigmentation1.27063514
49MP0002152_abnormal_brain_morphology1.26565067
50MP0001502_abnormal_circadian_rhythm1.23899619
51MP0000631_abnormal_neuroendocrine_gland1.17611607
52MP0005499_abnormal_olfactory_system1.15704468
53MP0005394_taste/olfaction_phenotype1.15704468
54MP0003633_abnormal_nervous_system1.14152797
55MP0001905_abnormal_dopamine_level1.12860282
56MP0002751_abnormal_autonomic_nervous1.12283979
57MP0005167_abnormal_blood-brain_barrier1.07547689
58MP0005409_darkened_coat_color1.03838179
59MP0003122_maternal_imprinting1.02627434
60MP0003329_amyloid_beta_deposits1.00289622
61MP0009379_abnormal_foot_pigmentation1.00017290
62MP0001485_abnormal_pinna_reflex0.99949046
63MP0000462_abnormal_digestive_system0.99383940
64MP0003631_nervous_system_phenotype0.99306674
65MP0001177_atelectasis0.97299286
66MP0002249_abnormal_larynx_morphology0.96781875
67MP0001963_abnormal_hearing_physiology0.95413442
68MP0002102_abnormal_ear_morphology0.94826024
69MP0005551_abnormal_eye_electrophysiolog0.93023607
70MP0003690_abnormal_glial_cell0.92098174
71MP0003283_abnormal_digestive_organ0.91796773
72MP0002229_neurodegeneration0.91672680
73MP0002069_abnormal_eating/drinking_beha0.90917526
74MP0002752_abnormal_somatic_nervous0.89618194
75MP0008872_abnormal_physiological_respon0.88867694
76MP0003861_abnormal_nervous_system0.88531865
77MP0005253_abnormal_eye_physiology0.88192931
78MP0003119_abnormal_digestive_system0.87887166
79MP0000049_abnormal_middle_ear0.87080624
80MP0003634_abnormal_glial_cell0.86724894
81MP0000920_abnormal_myelination0.85680002
82MP0000534_abnormal_ureter_morphology0.83352038
83MP0000579_abnormal_nail_morphology0.82921132
84MP0008874_decreased_physiological_sensi0.78136885
85MP0003115_abnormal_respiratory_system0.78002014
86MP0002653_abnormal_ependyma_morphology0.77508657
87MP0003183_abnormal_peptide_metabolism0.77481713
88MP0003632_abnormal_nervous_system0.77220022
89MP0004085_abnormal_heartbeat0.76206347
90MP0003136_yellow_coat_color0.74982562
91MP0005171_absent_coat_pigmentation0.74253403
92MP0002081_perinatal_lethality0.69969330
93MP0000026_abnormal_inner_ear0.69039101
94MP0004145_abnormal_muscle_electrophysio0.69030782
95MP0002638_abnormal_pupillary_reflex0.67734003
96MP0001346_abnormal_lacrimal_gland0.67242629
97MP0003137_abnormal_impulse_conducting0.66798897
98MP0008961_abnormal_basal_metabolism0.66785774
99MP0002116_abnormal_craniofacial_bone0.66430561
100MP0004133_heterotaxia0.65254771
101MP0003938_abnormal_ear_development0.64968179
102MP0005623_abnormal_meninges_morphology0.61284652
103MP0010769_abnormal_survival0.60357281
104MP0001664_abnormal_digestion0.60294048
105MP0003075_altered_response_to0.59940603
106MP0003121_genomic_imprinting0.59148393
107MP0002082_postnatal_lethality0.58777885
108MP0010770_preweaning_lethality0.58777885
109MP0001943_abnormal_respiration0.57759747
110MP0010768_mortality/aging0.57306116
111MP0001299_abnormal_eye_distance/0.56988665
112MP0000751_myopathy0.55620588
113MP0008789_abnormal_olfactory_epithelium0.55165204
114MP0002090_abnormal_vision0.54706588
115MP0006072_abnormal_retinal_apoptosis0.54131125

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.70293626
2Myokymia (HP:0002411)6.60767911
3Focal seizures (HP:0007359)5.16993936
4Epileptic encephalopathy (HP:0200134)4.42071706
5Visual hallucinations (HP:0002367)4.40556448
6Febrile seizures (HP:0002373)4.23884419
7Progressive cerebellar ataxia (HP:0002073)4.18356473
8Broad-based gait (HP:0002136)3.75278419
9Ankle clonus (HP:0011448)3.67459493
10Action tremor (HP:0002345)3.63361092
11Atonic seizures (HP:0010819)3.42261927
12Gaze-evoked nystagmus (HP:0000640)3.40252035
13Generalized tonic-clonic seizures (HP:0002069)3.33475966
14Urinary bladder sphincter dysfunction (HP:0002839)3.30853733
15Impaired vibration sensation in the lower limbs (HP:0002166)3.28274943
16Poor eye contact (HP:0000817)3.27995830
17Absence seizures (HP:0002121)3.27505283
18Dialeptic seizures (HP:0011146)3.09407903
19Supranuclear gaze palsy (HP:0000605)3.09187941
20Dysdiadochokinesis (HP:0002075)3.08557514
21Genetic anticipation (HP:0003743)2.99340928
22Peripheral hypomyelination (HP:0007182)2.98311905
23Mutism (HP:0002300)2.89871296
24Limb dystonia (HP:0002451)2.86552422
25Abnormality of the diencephalon (HP:0010662)2.85768553
26Hemiparesis (HP:0001269)2.85755944
27Impaired social interactions (HP:0000735)2.84665444
28Abnormal social behavior (HP:0012433)2.84665444
29Drooling (HP:0002307)2.84555376
30Excessive salivation (HP:0003781)2.84555376
31Spastic gait (HP:0002064)2.76905337
32Dysmetria (HP:0001310)2.74941768
33Hyperventilation (HP:0002883)2.73884156
34Depression (HP:0000716)2.72877473
35Hyperacusis (HP:0010780)2.65911079
36Postural instability (HP:0002172)2.64650114
37Elfin facies (HP:0004428)2.64318837
38Urinary urgency (HP:0000012)2.62451288
39Renovascular hypertension (HP:0100817)2.58090675
40Abnormal eating behavior (HP:0100738)2.54629639
41Abnormality of the corticospinal tract (HP:0002492)2.53633335
42Truncal ataxia (HP:0002078)2.53217927
43Overriding aorta (HP:0002623)2.50364772
44Anxiety (HP:0000739)2.48326615
45Stereotypic behavior (HP:0000733)2.45919539
46Absent speech (HP:0001344)2.45440181
47Papilledema (HP:0001085)2.43590370
48Amblyopia (HP:0000646)2.42881113
49Diplopia (HP:0000651)2.41554401
50Abnormality of binocular vision (HP:0011514)2.41554401
51Impaired smooth pursuit (HP:0007772)2.41130538
52Retinal dysplasia (HP:0007973)2.41108279
53Fetal akinesia sequence (HP:0001989)2.40468595
54Torticollis (HP:0000473)2.38257789
55Neoplasm of the heart (HP:0100544)2.35755109
56Scanning speech (HP:0002168)2.34057716
57Abnormality of the lower motor neuron (HP:0002366)2.30884364
58Intention tremor (HP:0002080)2.29734684
59Cerebral inclusion bodies (HP:0100314)2.28798314
60Split foot (HP:0001839)2.24440443
61Abnormality of ocular smooth pursuit (HP:0000617)2.19156316
62Lower limb muscle weakness (HP:0007340)2.19058910
63Focal dystonia (HP:0004373)2.17912711
64Obstructive sleep apnea (HP:0002870)2.16534816
65Oligodactyly (hands) (HP:0001180)2.15283474
66Bradykinesia (HP:0002067)2.15213884
67Epileptiform EEG discharges (HP:0011182)2.15192709
68Impaired vibratory sensation (HP:0002495)2.14466337
69Megalocornea (HP:0000485)2.13101056
70EEG with generalized epileptiform discharges (HP:0011198)2.11179201
71Hemiplegia (HP:0002301)2.09690852
72Polyphagia (HP:0002591)2.09529721
73Inappropriate behavior (HP:0000719)2.08963287
74Pointed chin (HP:0000307)2.06748803
75Aplasia/Hypoplasia of the sternum (HP:0006714)2.05004752
76Megalencephaly (HP:0001355)2.04615181
77Insidious onset (HP:0003587)2.03082861
78Termporal pattern (HP:0011008)2.03082861
79Hypoplasia of the corpus callosum (HP:0002079)2.02050666
80Hypsarrhythmia (HP:0002521)2.02003021
81Progressive inability to walk (HP:0002505)2.01878518
82Insomnia (HP:0100785)2.01402749
83Absent/shortened dynein arms (HP:0200106)2.00331434
84Dynein arm defect of respiratory motile cilia (HP:0012255)2.00331434
85Turricephaly (HP:0000262)1.99224161
86Specific learning disability (HP:0001328)1.95659108
87Obsessive-compulsive behavior (HP:0000722)1.94876151
88Alacrima (HP:0000522)1.92043857
89Amyotrophic lateral sclerosis (HP:0007354)1.91795894
90Germ cell neoplasia (HP:0100728)1.91099728
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.91026621
92Protruding tongue (HP:0010808)1.89954256
93Abnormality of salivation (HP:0100755)1.89759781
94Blue irides (HP:0000635)1.88865505
95Annular pancreas (HP:0001734)1.88416893
96Intestinal atresia (HP:0011100)1.88222106
97Hepatoblastoma (HP:0002884)1.87246371
98Neurofibrillary tangles (HP:0002185)1.86983814
99Clonus (HP:0002169)1.85722248
100Craniofacial dystonia (HP:0012179)1.85229702
101Incomplete penetrance (HP:0003829)1.85152335
102Generalized myoclonic seizures (HP:0002123)1.84383376
103Dysmetric saccades (HP:0000641)1.83132263
104Bowel diverticulosis (HP:0005222)1.80698083
105Lower limb amyotrophy (HP:0007210)1.80303447
106Akinesia (HP:0002304)1.80099006
107Gastroesophageal reflux (HP:0002020)1.77792197
108Abnormality of the 4th metacarpal (HP:0010012)1.75937091
109Astrocytoma (HP:0009592)1.75879428
110Abnormality of the astrocytes (HP:0100707)1.75879428
111Flat cornea (HP:0007720)1.75831884
112Autism (HP:0000717)1.75221425
113Aplasia involving bones of the upper limbs (HP:0009823)1.74449339
114Aplasia of the phalanges of the hand (HP:0009802)1.74449339
115Aplasia involving bones of the extremities (HP:0009825)1.74449339
116Sleep apnea (HP:0010535)1.74251916
117Abnormality of the labia minora (HP:0012880)1.73913107
118Morphological abnormality of the inner ear (HP:0011390)1.73324495
119Abnormal EKG (HP:0003115)1.73265664
120Aqueductal stenosis (HP:0002410)1.72698690
121Status epilepticus (HP:0002133)1.72693199
122Renal duplication (HP:0000075)1.72496909
123Short phalanx of the thumb (HP:0009660)1.72154246
124Cutaneous finger syndactyly (HP:0010554)1.71200689
125Increased nuchal translucency (HP:0010880)1.70574023
126Inability to walk (HP:0002540)1.69949898
127Laryngomalacia (HP:0001601)1.69716183
128Gait ataxia (HP:0002066)1.68982341
129Abnormality of the 1st metacarpal (HP:0010009)1.68817110
130Agitation (HP:0000713)1.68396440
131Neoplasm of the oral cavity (HP:0100649)1.67631035
132Degeneration of the lateral corticospinal tracts (HP:0002314)1.67448256
133Shawl scrotum (HP:0000049)1.66581975
134Hypoventilation (HP:0002791)1.65082013
135Cortical dysplasia (HP:0002539)1.62788931
136Vitreoretinal degeneration (HP:0000655)1.60776943
137Renal hypoplasia (HP:0000089)1.60069072
138Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.59599291
139Intellectual disability, severe (HP:0010864)1.59564163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.40948630
2MARK14.33237833
3NTRK33.98177681
4MAP3K93.49593328
5MAP3K42.74119848
6NTRK22.44385100
7MAP2K72.43501790
8MINK12.31620047
9DAPK22.30668033
10CASK2.19433311
11SIK22.18267874
12TNIK2.16152626
13PAK62.07388243
14PRPF4B1.94115929
15MAPK131.84300041
16PRKD31.71856515
17CAMKK11.53946316
18INSRR1.53021086
19KSR11.52874191
20CDK51.51957552
21TYRO31.49336323
22MAP2K41.49072673
23KSR21.45760717
24FGFR21.42489012
25RIPK41.41077559
26NTRK11.38035262
27DAPK11.36498370
28PNCK1.35063280
29RIPK11.31608649
30MAP3K121.29672465
31UHMK11.28246926
32PDGFRA1.22949677
33STK381.16300633
34MARK21.16169716
35FES1.15440587
36PHKG21.15302386
37PHKG11.15302386
38GRK51.14925303
39CDK191.14320191
40SIK31.09659454
41ERBB21.08760352
42PRKCG1.08183030
43ERBB41.05079077
44SGK4941.00917799
45SGK2231.00917799
46PLK21.00885985
47CAMK10.98412646
48MAP3K20.97338358
49LATS20.96646315
50STK110.96545576
51SGK20.90567920
52ALK0.89458832
53CCNB10.88609303
54TRIB30.87679379
55CAMK2A0.87579587
56CDK180.85757713
57TAOK10.84952090
58CDK150.84725216
59DYRK1A0.82796072
60PKN10.81294080
61MKNK20.79425982
62ROCK20.79423042
63NEK60.79070293
64CSNK1G20.77666560
65CDK140.77237397
66CAMK2G0.75364717
67CDK11A0.74655297
68SGK10.74406847
69OXSR10.74036557
70CDK30.73390818
71SGK30.72453151
72CSNK1A1L0.72119247
73BMPR20.72047657
74CSNK1G30.68720053
75CAMK40.68404526
76CAMK2B0.68165870
77PRKCH0.67804960
78CAMKK20.66865496
79MAP3K130.62010858
80PINK10.61923441
81AKT30.60433986
82CDC42BPA0.60112832
83RET0.59301341
84PDGFRB0.57546917
85WNK30.57345286
86CSNK1G10.56740299
87TNK20.56264113
88CAMK1G0.54216866
89ROCK10.53297768
90CAMK1D0.52702073
91RPS6KA30.51959871
92BRD40.51230967
93ICK0.51190086
94ERBB30.50054617
95DYRK20.49682616
96ARAF0.49446688
97PRKCZ0.48826135
98PAK30.48349756
99ADRBK20.47605654
100MAP3K100.47568928
101MAPK100.47304708
102PRKAA10.46743088
103EPHA30.46683710
104MAPK120.46256228
105FYN0.45250760
106PRKCE0.44964189
107FGR0.44920275
108PRKD20.43189207
109EPHB20.42935455
110RPS6KA20.42654345
111DDR20.42401375
112MAP3K60.40181590
113PRKDC0.39489642
114WNK10.37871353
115IRAK20.37320312
116FRK0.36795322
117CSNK1D0.36207887
118CSNK1A10.35536829
119RAF10.35536612
120PDK10.35059258
121GSK3B0.33848595
122PRKCB0.33591133
123BCR0.32853626
124CSNK1E0.32783006
125MAP3K70.31908674
126CAMK2D0.31536096
127MAPK80.31263380
128PRKG10.31234574

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.86288627
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09731773
3Olfactory transduction_Homo sapiens_hsa047402.88503168
4GABAergic synapse_Homo sapiens_hsa047272.82003732
5Circadian entrainment_Homo sapiens_hsa047132.78785639
6* Glutamatergic synapse_Homo sapiens_hsa047242.71900980
7Morphine addiction_Homo sapiens_hsa050322.71788744
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71138082
9Long-term potentiation_Homo sapiens_hsa047202.43949379
10Amphetamine addiction_Homo sapiens_hsa050312.35669292
11Dopaminergic synapse_Homo sapiens_hsa047282.17396649
12Salivary secretion_Homo sapiens_hsa049702.06137423
13Cholinergic synapse_Homo sapiens_hsa047252.00398832
14Cocaine addiction_Homo sapiens_hsa050301.87724558
15Insulin secretion_Homo sapiens_hsa049111.85130691
16Taste transduction_Homo sapiens_hsa047421.83763234
17Serotonergic synapse_Homo sapiens_hsa047261.83247867
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82733754
19Long-term depression_Homo sapiens_hsa047301.79871226
20Gastric acid secretion_Homo sapiens_hsa049711.74594848
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69899792
22Oxytocin signaling pathway_Homo sapiens_hsa049211.65073627
23Calcium signaling pathway_Homo sapiens_hsa040201.62382720
24Renin secretion_Homo sapiens_hsa049241.60279149
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58883913
26Axon guidance_Homo sapiens_hsa043601.53829105
27Gap junction_Homo sapiens_hsa045401.45883418
28GnRH signaling pathway_Homo sapiens_hsa049121.42491001
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32894769
30Type II diabetes mellitus_Homo sapiens_hsa049301.31592064
31cAMP signaling pathway_Homo sapiens_hsa040241.30747644
32* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28999968
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26596414
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21895760
35ErbB signaling pathway_Homo sapiens_hsa040121.18975453
36Notch signaling pathway_Homo sapiens_hsa043301.17446978
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16068057
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14590775
39Estrogen signaling pathway_Homo sapiens_hsa049151.09686073
40Glioma_Homo sapiens_hsa052141.06404726
41Melanogenesis_Homo sapiens_hsa049161.05684561
42Collecting duct acid secretion_Homo sapiens_hsa049661.01803041
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95908150
44Phototransduction_Homo sapiens_hsa047440.95896763
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.92360410
46Bile secretion_Homo sapiens_hsa049760.88961733
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.88861201
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85820667
49Choline metabolism in cancer_Homo sapiens_hsa052310.84422116
50MAPK signaling pathway_Homo sapiens_hsa040100.83849917
51Dorso-ventral axis formation_Homo sapiens_hsa043200.82930661
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81831538
53Oocyte meiosis_Homo sapiens_hsa041140.80383424
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78568963
55Cardiac muscle contraction_Homo sapiens_hsa042600.77840270
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75209682
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74132623
58Alcoholism_Homo sapiens_hsa050340.73972895
59Dilated cardiomyopathy_Homo sapiens_hsa054140.73321871
60Ras signaling pathway_Homo sapiens_hsa040140.73180954
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71621825
62Wnt signaling pathway_Homo sapiens_hsa043100.70497753
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70475868
64Pancreatic secretion_Homo sapiens_hsa049720.68955092
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68550128
66Rap1 signaling pathway_Homo sapiens_hsa040150.67909187
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66056035
68Endometrial cancer_Homo sapiens_hsa052130.64730792
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63196181
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62830485
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.61782164
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60998614
73AMPK signaling pathway_Homo sapiens_hsa041520.60698371
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60209033
75Thyroid hormone synthesis_Homo sapiens_hsa049180.60161448
76Prolactin signaling pathway_Homo sapiens_hsa049170.59851319
77mTOR signaling pathway_Homo sapiens_hsa041500.59557938
78Nitrogen metabolism_Homo sapiens_hsa009100.56950021
79MicroRNAs in cancer_Homo sapiens_hsa052060.56230310
80Ovarian steroidogenesis_Homo sapiens_hsa049130.55005284
81Circadian rhythm_Homo sapiens_hsa047100.54975157
82Type I diabetes mellitus_Homo sapiens_hsa049400.54872627
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.54823805
84Vibrio cholerae infection_Homo sapiens_hsa051100.54111678
85Renal cell carcinoma_Homo sapiens_hsa052110.52550167
86Basal cell carcinoma_Homo sapiens_hsa052170.52390208
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52346433
88Hedgehog signaling pathway_Homo sapiens_hsa043400.51877692
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50052020
90VEGF signaling pathway_Homo sapiens_hsa043700.48690473
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48426277
92Non-small cell lung cancer_Homo sapiens_hsa052230.47589801
93Colorectal cancer_Homo sapiens_hsa052100.47454208
94Inositol phosphate metabolism_Homo sapiens_hsa005620.46476832
95Endocytosis_Homo sapiens_hsa041440.46439229
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44670184
97Chemokine signaling pathway_Homo sapiens_hsa040620.42609515
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41449145
99Butanoate metabolism_Homo sapiens_hsa006500.40540294
100Insulin signaling pathway_Homo sapiens_hsa049100.40438384
101Lysine degradation_Homo sapiens_hsa003100.39875815
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39640502
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39264546
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38018659
105Melanoma_Homo sapiens_hsa052180.36929561
106African trypanosomiasis_Homo sapiens_hsa051430.36138036
107ABC transporters_Homo sapiens_hsa020100.36103800
108Tight junction_Homo sapiens_hsa045300.35616096
109Hippo signaling pathway_Homo sapiens_hsa043900.35077798
110Prion diseases_Homo sapiens_hsa050200.34778833
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34041311
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33756940
113Glucagon signaling pathway_Homo sapiens_hsa049220.33618493
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33430250

Most similar genes based on co-expression Upload to Enrichr

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