GRID2IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006 [PubMed 16835239]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.41652219
2cerebellar granule cell differentiation (GO:0021707)7.28871737
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.91871035
4synaptic vesicle maturation (GO:0016188)5.83277686
5cerebellar Purkinje cell differentiation (GO:0021702)5.74010858
6positive thymic T cell selection (GO:0045059)5.70326938
7locomotory exploration behavior (GO:0035641)5.66868108
8gamma-aminobutyric acid transport (GO:0015812)5.62574560
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.56644329
10cellular potassium ion homeostasis (GO:0030007)5.54546441
11positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.51860151
12neuronal action potential propagation (GO:0019227)5.50857251
13G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.48126263
14cell differentiation in hindbrain (GO:0021533)5.29898360
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.29847717
16neuromuscular process controlling posture (GO:0050884)5.20439295
17vocalization behavior (GO:0071625)5.19990549
18negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.17388031
19ionotropic glutamate receptor signaling pathway (GO:0035235)5.16051291
20digestion (GO:0007586)5.07305437
21glutamate receptor signaling pathway (GO:0007215)5.02863601
22sodium ion export (GO:0071436)4.97457926
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.94606230
24neurotransmitter secretion (GO:0007269)4.82133471
25hyperosmotic salinity response (GO:0042538)4.77641384
26synaptic transmission, glutamatergic (GO:0035249)4.75046526
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.68570807
28synaptic vesicle exocytosis (GO:0016079)4.60297925
29Arp2/3 complex-mediated actin nucleation (GO:0034314)4.57962340
30regulation of synaptic vesicle exocytosis (GO:2000300)4.49501298
31mitochondrial DNA replication (GO:0006264)4.45665857
32negative regulation of B cell apoptotic process (GO:0002903)4.40889444
33histone H3-K9 methylation (GO:0051567)4.38182842
34positive regulation of synapse maturation (GO:0090129)4.38176163
35post-embryonic morphogenesis (GO:0009886)4.32329483
36interferon-gamma secretion (GO:0072643)4.25978928
37leukotriene biosynthetic process (GO:0019370)4.25873203
38glutamate secretion (GO:0014047)4.24307956
39positive T cell selection (GO:0043368)4.22945158
40hydrogen peroxide metabolic process (GO:0042743)4.11600567
41calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.10866653
42glutathione biosynthetic process (GO:0006750)4.10771505
43histone H3-K9 modification (GO:0061647)4.08939091
44layer formation in cerebral cortex (GO:0021819)4.07778493
45neuron-neuron synaptic transmission (GO:0007270)4.06859907
46neuromuscular process controlling balance (GO:0050885)4.04780848
47peroxisome fission (GO:0016559)4.03948540
48mannose metabolic process (GO:0006013)4.03806951
49regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4.01873412
50neurotransmitter transport (GO:0006836)4.00730294
51long-term memory (GO:0007616)4.00228225
52dicarboxylic acid catabolic process (GO:0043649)4.00087767
53chaperone mediated protein folding requiring cofactor (GO:0051085)3.99057259
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.94842196
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.94420132
56transmission of nerve impulse (GO:0019226)3.94027218
57negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.93671325
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.92954220
59actin nucleation (GO:0045010)3.91102964
60regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.90359654
61synaptic vesicle endocytosis (GO:0048488)3.89912386
62membrane budding (GO:0006900)3.85881090
63regulation of synaptic vesicle transport (GO:1902803)3.82974986
64positive regulation of CREB transcription factor activity (GO:0032793)3.82383640
65energy homeostasis (GO:0097009)3.81347909
66regulation of glutamate receptor signaling pathway (GO:1900449)3.77349396
67cell morphogenesis involved in neuron differentiation (GO:0048667)3.75744911
68proline transport (GO:0015824)3.75246885
69potassium ion import (GO:0010107)3.74514555
70exploration behavior (GO:0035640)3.74442682
71regulation of germinal center formation (GO:0002634)3.73733469
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.72497743
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71766952
74potassium ion homeostasis (GO:0055075)3.70278511
75regulation of neurotransmitter levels (GO:0001505)3.67243030
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64149547
77cysteine metabolic process (GO:0006534)3.63633101
78protein localization to synapse (GO:0035418)3.62928515
79maintenance of gastrointestinal epithelium (GO:0030277)3.62778064
80mucosal-associated lymphoid tissue development (GO:0048537)3.61704938
81Peyers patch development (GO:0048541)3.61704938
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.60772973
83adult walking behavior (GO:0007628)3.57005985
84glycine transport (GO:0015816)3.56222656
85nonribosomal peptide biosynthetic process (GO:0019184)3.56177260
86membrane depolarization during action potential (GO:0086010)3.55751055
87dendritic spine morphogenesis (GO:0060997)3.53115230
88auditory behavior (GO:0031223)3.52726400
89cell communication by electrical coupling (GO:0010644)3.52253218
90neuron cell-cell adhesion (GO:0007158)3.49566960
91regulation of excitatory postsynaptic membrane potential (GO:0060079)3.46028322
92peptidyl-lysine dimethylation (GO:0018027)3.45232322
93negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.44570167
94synaptic vesicle docking involved in exocytosis (GO:0016081)3.40464362
95positive regulation of B cell differentiation (GO:0045579)3.40287550
96regulation of synapse maturation (GO:0090128)3.38031101
97detection of temperature stimulus (GO:0016048)3.37614398
98cell migration in hindbrain (GO:0021535)3.37327832
99chemosensory behavior (GO:0007635)3.36633709
100regulation of hormone metabolic process (GO:0032350)3.35862812
101regulation of neurotransmitter secretion (GO:0046928)3.32680394
102regulation of postsynaptic membrane potential (GO:0060078)3.32433385
103regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.32250061
104short-chain fatty acid metabolic process (GO:0046459)3.31755152
105mating behavior (GO:0007617)3.31497811
106regulation of long-term neuronal synaptic plasticity (GO:0048169)3.30911562
107collecting duct development (GO:0072044)3.30610464
108dendrite morphogenesis (GO:0048813)3.29834973
109pyrimidine nucleoside salvage (GO:0043097)3.29491670
110pyrimidine-containing compound salvage (GO:0008655)3.29491670
111establishment of nucleus localization (GO:0040023)3.29312782
112membrane hyperpolarization (GO:0060081)3.27873604
113mitochondrion transport along microtubule (GO:0047497)3.27559348
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.27559348
115C4-dicarboxylate transport (GO:0015740)3.26187170
116neuromuscular process (GO:0050905)3.25283663
117positive regulation of potassium ion transmembrane transport (GO:1901381)3.24398655
118negative regulation of synaptic transmission, GABAergic (GO:0032229)3.22372485
119regulation of neuronal synaptic plasticity (GO:0048168)3.21643521
120membrane depolarization (GO:0051899)3.21084121
121DNA deamination (GO:0045006)3.20597145
122regulation of B cell apoptotic process (GO:0002902)3.18150576
123folic acid metabolic process (GO:0046655)3.17653794
124cellular response to fluid shear stress (GO:0071498)3.17072791
125positive regulation of membrane potential (GO:0045838)3.16746034
126musculoskeletal movement (GO:0050881)3.16542764
127multicellular organismal movement (GO:0050879)3.16542764
128negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16390312
129neurotransmitter-gated ion channel clustering (GO:0072578)3.16004900
130negative regulation of hormone metabolic process (GO:0032351)3.12780943
131negative regulation of hormone biosynthetic process (GO:0032353)3.12780943
132mechanosensory behavior (GO:0007638)3.11286751
133cellular sodium ion homeostasis (GO:0006883)3.10592742
134fatty acid derivative biosynthetic process (GO:1901570)3.09968092
135icosanoid biosynthetic process (GO:0046456)3.09968092
136immunoglobulin mediated immune response (GO:0016064)3.09630038
137peptide catabolic process (GO:0043171)3.09519845
138regulation of acrosome reaction (GO:0060046)3.08815804
139water-soluble vitamin metabolic process (GO:0006767)3.08698218
140regulation of neurotransmitter transport (GO:0051588)3.05031752
141response to auditory stimulus (GO:0010996)3.04795668
142thymic T cell selection (GO:0045061)3.02609627
143activation of protein kinase A activity (GO:0034199)3.02018643
144positive regulation of dendritic spine morphogenesis (GO:0061003)3.01218094
145regulation of calcium ion-dependent exocytosis (GO:0017158)3.01124305
146synapse assembly (GO:0007416)2.98373737
147negative regulation of transcription by competitive promoter binding (GO:0010944)2.96655205
148detection of temperature stimulus involved in sensory perception (GO:0050961)2.96534940
149detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.96534940
150cytoskeletal anchoring at plasma membrane (GO:0007016)2.95884024
151gonadal mesoderm development (GO:0007506)2.95477861
152neuromuscular synaptic transmission (GO:0007274)2.94579313
153regulation of respiratory system process (GO:0044065)2.90377758
154DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.89980776
155B cell receptor signaling pathway (GO:0050853)2.89677312
156regulation of synaptic transmission, glutamatergic (GO:0051966)2.89102462
157short-term memory (GO:0007614)2.88485834
158mitochondrial DNA metabolic process (GO:0032042)2.88407926
159regulation of respiratory gaseous exchange (GO:0043576)2.86369616
160regulation of response to osmotic stress (GO:0047484)2.86155850
161positive regulation of dendritic spine development (GO:0060999)2.85311388
162auditory receptor cell stereocilium organization (GO:0060088)2.83741448
163spinal cord development (GO:0021510)2.82963224
164regulation of penile erection (GO:0060405)2.81209467
165innervation (GO:0060384)2.80684018
166synapse organization (GO:0050808)2.80264678
167regulation of voltage-gated calcium channel activity (GO:1901385)2.79989100
168peptide biosynthetic process (GO:0043043)2.79881880
169positive regulation of macrophage cytokine production (GO:0060907)2.78061885
170positive regulation of respiratory burst (GO:0060267)2.77309761
171negative regulation of activin receptor signaling pathway (GO:0032926)2.76106187
172negative regulation of myeloid cell apoptotic process (GO:0033033)2.73085253
173negative regulation of osteoblast proliferation (GO:0033689)2.71208072
174tetrapyrrole metabolic process (GO:0033013)2.69855932
175positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.67906688
176oxaloacetate metabolic process (GO:0006107)2.67779870
177cytidine catabolic process (GO:0006216)2.64616094
178cytidine deamination (GO:0009972)2.64616094
179cytidine metabolic process (GO:0046087)2.64616094
180leukotriene metabolic process (GO:0006691)2.61781569
181establishment of mitochondrion localization (GO:0051654)2.59636840
182cilium or flagellum-dependent cell motility (GO:0001539)2.59061863
183protein insertion into membrane (GO:0051205)2.57744816
184regulation of hypersensitivity (GO:0002883)2.56526276
185phosphatidylserine acyl-chain remodeling (GO:0036150)2.55724919
186epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52947482
187DNA damage response, signal transduction resulting in transcription (GO:0042772)2.51961308
188vitamin A metabolic process (GO:0006776)2.50304384
189regulation of cellular amino acid metabolic process (GO:0006521)2.47416011
190N-acetylglucosamine metabolic process (GO:0006044)2.45892365
191regulation of respiratory burst (GO:0060263)2.44342911
192rhodopsin mediated signaling pathway (GO:0016056)2.44176523
193positive regulation of prostaglandin secretion (GO:0032308)2.43970822
194positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.42660042
195cobalamin metabolic process (GO:0009235)10.0940886

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.38131148
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.78542091
3EZH2_22144423_ChIP-Seq_EOC_Human4.69389398
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.38400743
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.01825306
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.98153099
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97292583
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.92993009
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.92605805
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.92605805
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77065299
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76862908
13DROSHA_22980978_ChIP-Seq_HELA_Human2.74932842
14* REST_21632747_ChIP-Seq_MESCs_Mouse2.65885000
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58586479
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39956209
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38932888
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.31327212
19* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30566330
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29501997
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.27184426
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.26837456
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26755343
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.26669113
25SRY_22984422_ChIP-ChIP_TESTIS_Rat2.26202326
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22821949
27ELF1_20517297_ChIP-Seq_JURKAT_Human2.21370424
28* EED_16625203_ChIP-ChIP_MESCs_Mouse2.21304057
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.15999335
30ERG_21242973_ChIP-ChIP_JURKAT_Human2.14929759
31* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12556767
32GBX2_23144817_ChIP-Seq_PC3_Human2.10484628
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.97694027
34* P68_20966046_ChIP-Seq_HELA_Human1.96400742
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.95580188
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90202491
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89921392
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88443785
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84804632
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80046545
41PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.77853373
42KDM2B_26808549_Chip-Seq_K562_Human1.77166140
43* BCOR_27268052_Chip-Seq_Bcells_Human1.75086453
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70083865
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69019002
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.68650930
47* E2F1_20622854_ChIP-Seq_HELA_Human1.68309820
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68152395
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.66853883
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66529043
51* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.63828481
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61423916
53BCL6_27268052_Chip-Seq_Bcells_Human1.60822085
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.60243241
55* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.57907621
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.55641419
57CIITA_25753668_ChIP-Seq_RAJI_Human1.54866147
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53470164
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.52887065
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51734810
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51339001
62* P300_27268052_Chip-Seq_Bcells_Human1.48854328
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47704542
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47173773
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.46138165
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.40731918
67* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39495820
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39211452
69* PHF8_20622854_ChIP-Seq_HELA_Human1.38712684
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36223931
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35568246
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.33127433
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.31249514
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31158199
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29747309
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.29312090
77RAC3_21632823_ChIP-Seq_H3396_Human1.28976134
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27329672
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26652740
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25935698
81RACK7_27058665_Chip-Seq_MCF-7_Human1.25415750
82TAF2_19829295_ChIP-Seq_ESCs_Human1.24807500
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24734443
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.24028285
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23471210
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22457250
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22457250
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22457250
89AR_19668381_ChIP-Seq_PC3_Human1.22303103
90ERA_21632823_ChIP-Seq_H3396_Human1.22156648
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22035013
92TP63_22573176_ChIP-Seq_HFKS_Human1.21263228
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19197311
94* OCT4_19829295_ChIP-Seq_ESCs_Human1.19066083
95SMAD4_21799915_ChIP-Seq_A2780_Human1.18846453
96* RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18704757
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18472685
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18310581
99SCL_19346495_ChIP-Seq_HPC-7_Human1.18166002
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16181163
101CTCF_20526341_ChIP-Seq_ESCs_Human1.15963016
102STAT1_20625510_ChIP-Seq_HELA_Human1.15555964
103OCT4_20526341_ChIP-Seq_ESCs_Human1.15387021
104RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15114847
105FLI1_21867929_ChIP-Seq_CD8_Mouse1.14940747
106* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14501231
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14449835
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.14278829
109ZNF274_21170338_ChIP-Seq_K562_Hela1.14223353
110* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14067623
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12987888
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11926051
113CREB1_26743006_Chip-Seq_LNCaP_Human1.10284033
114SA1_27219007_Chip-Seq_Bcells_Human1.10140590
115YY1_22570637_ChIP-Seq_MALME-3M_Human1.09843867
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09773354
117TCF7_22412390_ChIP-Seq_EML_Mouse1.09415763
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09406780
119AHR_22903824_ChIP-Seq_MCF-7_Human1.09271386
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09052025
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08797380
122UTX_26944678_Chip-Seq_JUKART_Human1.07673070
123RNF2_27304074_Chip-Seq_NSC_Mouse1.06769166
124* TET1_21490601_ChIP-Seq_MESCs_Mouse1.05330984
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04772387
126STAT3_23295773_ChIP-Seq_U87_Human1.04770100
127VDR_24763502_ChIP-Seq_THP-1_Human1.04525724
128AR_21572438_ChIP-Seq_LNCaP_Human1.04107652
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03303828
130ESR2_21235772_ChIP-Seq_MCF-7_Human1.02634107
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02149189
132FOXP1_21924763_ChIP-Seq_HESCs_Human1.01271001
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00594898
134SOX2_21211035_ChIP-Seq_LN229_Gbm1.00255259
135CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98676017
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98657078
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98277568
138TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98032964
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97645208
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97334005
141CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97328643
142SPI1_23127762_ChIP-Seq_K562_Human0.95998331
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95692804
144RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95357783
145P53_21459846_ChIP-Seq_SAOS-2_Human0.94547611
146STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94250659
147PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93133760
148SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92538450
149CTCF_27219007_Chip-Seq_Bcells_Human0.91914526
150ETS1_21867929_ChIP-Seq_TH2_Mouse0.91431955
151CBX2_27304074_Chip-Seq_ESCs_Mouse0.91257936
152CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90804139
153* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90190727
154DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90125698
155* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89766162
156OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89763205
157KDM2B_26808549_Chip-Seq_JURKAT_Human0.88652280
158SMAD_19615063_ChIP-ChIP_OVARY_Human0.88636448
159LXR_22292898_ChIP-Seq_THP-1_Human0.88428796
160SMAD4_21741376_ChIP-Seq_HESCs_Human0.88258536
161POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87484362
162SMC4_20622854_ChIP-Seq_HELA_Human0.86591389
163SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86466755
164SMAD3_21741376_ChIP-Seq_ESCs_Human0.85854820
165CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85622609
166ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85052612
167CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84306658
168DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83989624
169TP53_16413492_ChIP-PET_HCT116_Human0.82692979
170POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82307015
171TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82307015
172NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81490998
173P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81447692
174SMAD3_21741376_ChIP-Seq_HESCs_Human0.81301800
175TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.81016537
176KDM2B_26808549_Chip-Seq_DND41_Human0.80612592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009046_muscle_twitch5.08625302
2MP0004859_abnormal_synaptic_plasticity5.00550708
3MP0003011_delayed_dark_adaptation3.93322552
4* MP0003635_abnormal_synaptic_transmissio3.81171801
5MP0005423_abnormal_somatic_nervous3.33840798
6MP0003195_calcinosis3.24248403
7MP0008569_lethality_at_weaning3.21900013
8MP0002064_seizures3.11021490
9MP0002272_abnormal_nervous_system3.07074764
10MP0009745_abnormal_behavioral_response2.99720803
11MP0003880_abnormal_central_pattern2.98048207
12MP0004270_analgesia2.91896439
13MP0002876_abnormal_thyroid_physiology2.90929131
14MP0009278_abnormal_bone_marrow2.84242888
15MP0002734_abnormal_mechanical_nocicepti2.67663531
16MP0008877_abnormal_DNA_methylation2.65939295
17MP0002063_abnormal_learning/memory/cond2.65268858
18MP0002572_abnormal_emotion/affect_behav2.56568480
19MP0002184_abnormal_innervation2.55963333
20MP0003136_yellow_coat_color2.51624350
21MP0001968_abnormal_touch/_nociception2.48938918
22MP0004145_abnormal_muscle_electrophysio2.47807914
23* MP0002067_abnormal_sensory_capabilities2.44837386
24MP0001486_abnormal_startle_reflex2.41293749
25MP0003172_abnormal_lysosome_physiology2.37879020
26MP0004858_abnormal_nervous_system2.34070916
27MP0001873_stomach_inflammation2.33475203
28MP0001501_abnormal_sleep_pattern2.31552323
29MP0001440_abnormal_grooming_behavior2.31184418
30MP0004142_abnormal_muscle_tone2.24778882
31MP0003806_abnormal_nucleotide_metabolis2.17158373
32MP0002733_abnormal_thermal_nociception2.09824729
33MP0002735_abnormal_chemical_nociception2.03585124
34MP0003656_abnormal_erythrocyte_physiolo2.02533533
35MP0008995_early_reproductive_senescence2.00130062
36MP0000955_abnormal_spinal_cord1.94187373
37MP0001970_abnormal_pain_threshold1.93773127
38MP0002736_abnormal_nociception_after1.88416942
39MP0004885_abnormal_endolymph1.85177201
40MP0000681_abnormal_thyroid_gland1.82642727
41MP0000685_abnormal_immune_system1.81315912
42MP0002396_abnormal_hematopoietic_system1.74851959
43MP0002557_abnormal_social/conspecific_i1.67099899
44MP0003879_abnormal_hair_cell1.66213132
45MP0000778_abnormal_nervous_system1.64161730
46MP0000465_gastrointestinal_hemorrhage1.63555903
47MP0005387_immune_system_phenotype1.61542953
48MP0001790_abnormal_immune_system1.61542953
49MP0005386_behavior/neurological_phenoty1.55686154
50MP0004924_abnormal_behavior1.55686154
51MP0000678_abnormal_parathyroid_gland1.55077101
52MP0003122_maternal_imprinting1.54966027
53* MP0002066_abnormal_motor_capabilities/c1.53043361
54MP0003632_abnormal_nervous_system1.51916276
55MP0005365_abnormal_bile_salt1.51175191
56MP0003329_amyloid_beta_deposits1.50701567
57MP0002882_abnormal_neuron_morphology1.47573834
58MP0004811_abnormal_neuron_physiology1.44839990
59MP0010234_abnormal_vibrissa_follicle1.43496796
60MP0000538_abnormal_urinary_bladder1.41795493
61MP0004742_abnormal_vestibular_system1.41163366
62MP0008875_abnormal_xenobiotic_pharmacok1.41133393
63MP0005085_abnormal_gallbladder_physiolo1.37130043
64MP0005623_abnormal_meninges_morphology1.36480513
65MP0003633_abnormal_nervous_system1.34071491
66MP0006072_abnormal_retinal_apoptosis1.33859139
67MP0002909_abnormal_adrenal_gland1.33533745
68MP0008872_abnormal_physiological_respon1.33227646
69MP0003283_abnormal_digestive_organ1.29753033
70MP0005499_abnormal_olfactory_system1.29693148
71MP0005394_taste/olfaction_phenotype1.29693148
72MP0001664_abnormal_digestion1.28680411
73MP0005076_abnormal_cell_differentiation1.27618500
74MP0003787_abnormal_imprinting1.26954924
75MP0009333_abnormal_splenocyte_physiolog1.26442265
76MP0004043_abnormal_pH_regulation1.26180218
77MP0003631_nervous_system_phenotype1.25983638
78MP0000372_irregular_coat_pigmentation1.25111075
79MP0003303_peritoneal_inflammation1.24630678
80MP0002152_abnormal_brain_morphology1.20704092
81MP0001502_abnormal_circadian_rhythm1.19411514
82MP0005671_abnormal_response_to1.18597553
83MP0001485_abnormal_pinna_reflex1.17393565
84MP0002653_abnormal_ependyma_morphology1.15407945
85MP0001661_extended_life_span1.12531157
86MP0005645_abnormal_hypothalamus_physiol1.11089267
87MP0002089_abnormal_postnatal_growth/wei1.10666742
88MP0002229_neurodegeneration1.10379546
89MP0003045_fibrosis1.10213292
90MP0003718_maternal_effect1.09911028
91MP0001764_abnormal_homeostasis1.07795730
92MP0005310_abnormal_salivary_gland1.07634114
93MP0006276_abnormal_autonomic_nervous1.06920759
94MP0001835_abnormal_antigen_presentation1.06756990
95MP0003137_abnormal_impulse_conducting1.06512846
96MP0003690_abnormal_glial_cell1.05321309
97MP0003638_abnormal_response/metabolism_1.03912040
98MP0000920_abnormal_myelination1.03349805
99MP0001963_abnormal_hearing_physiology1.02284991
100MP0001348_abnormal_lacrimal_gland1.02086701
101MP0005397_hematopoietic_system_phenotyp1.01638932
102MP0001545_abnormal_hematopoietic_system1.01638932
103MP0002752_abnormal_somatic_nervous1.00869402
104MP0005551_abnormal_eye_electrophysiolog0.99957373
105MP0005083_abnormal_biliary_tract0.98290435
106MP0005647_abnormal_sex_gland0.97207538
107MP0001800_abnormal_humoral_immune0.96278984
108MP0001984_abnormal_olfaction0.94736113
109MP0005646_abnormal_pituitary_gland0.93626100
110MP0000371_diluted_coat_color0.91647199
111MP0003866_abnormal_defecation0.88649059
112MP0004147_increased_porphyrin_level0.87368289
113MP0003634_abnormal_glial_cell0.85836650
114MP0004808_abnormal_hematopoietic_stem0.85103381
115MP0005220_abnormal_exocrine_pancreas0.82826503
116MP0002019_abnormal_tumor_incidence0.82628442
117MP0001666_abnormal_nutrient_absorption0.81486587
118MP0003861_abnormal_nervous_system0.81272241
119MP0003183_abnormal_peptide_metabolism0.80203578
120MP0000013_abnormal_adipose_tissue0.80060362
121MP0008961_abnormal_basal_metabolism0.78428190
122MP0002166_altered_tumor_susceptibility0.77869846
123MP0002138_abnormal_hepatobiliary_system0.77669929
124MP0005253_abnormal_eye_physiology0.77049462
125MP0006292_abnormal_olfactory_placode0.77028942
126MP0009643_abnormal_urine_homeostasis0.77017156
127MP0010769_abnormal_survival0.76040108
128MP0005075_abnormal_melanosome_morpholog0.73453797
129MP0003121_genomic_imprinting0.73298686
130MP0010768_mortality/aging0.73156406
131MP0005025_abnormal_response_to0.72914371
132MP0002638_abnormal_pupillary_reflex0.72306011
133MP0001765_abnormal_ion_homeostasis0.72197788
134MP0000579_abnormal_nail_morphology0.71717044
135MP0008874_decreased_physiological_sensi0.71371060
136MP0004264_abnormal_extraembryonic_tissu0.71202315
137MP0002069_abnormal_eating/drinking_beha0.70392981
138MP0001299_abnormal_eye_distance/0.70377403
139MP0002098_abnormal_vibrissa_morphology0.70339802
140MP0002723_abnormal_immune_serum0.70190224
141MP0004233_abnormal_muscle_weight0.69968135
142MP0005448_abnormal_energy_balance0.69831311
143MP0002332_abnormal_exercise_endurance0.69806203
144MP0005636_abnormal_mineral_homeostasis0.68756070
145MP0002082_postnatal_lethality0.68664530
146MP0010770_preweaning_lethality0.68664530
147MP0000026_abnormal_inner_ear0.68029216
148MP0000716_abnormal_immune_system0.67876469
149MP0001943_abnormal_respiration0.67711643
150MP0005501_abnormal_skin_physiology0.67501993
151MP0004085_abnormal_heartbeat0.67444668
152MP0005266_abnormal_metabolism0.67432618
153MP0010386_abnormal_urinary_bladder0.66356872
154MP0004215_abnormal_myocardial_fiber0.65826831
155MP0005391_vision/eye_phenotype0.65261706
156MP0005167_abnormal_blood-brain_barrier0.61380978
157MP0000569_abnormal_digit_pigmentation0.59898427
158MP0000639_abnormal_adrenal_gland0.59159138
159MP0003123_paternal_imprinting0.58895462
160MP0000631_abnormal_neuroendocrine_gland0.57600814
161MP0003890_abnormal_embryonic-extraembry0.56785136
162MP0000751_myopathy0.56782217
163MP0005171_absent_coat_pigmentation0.56762800

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.09020644
2Progressive cerebellar ataxia (HP:0002073)6.49409769
3Action tremor (HP:0002345)6.32291546
4Visual hallucinations (HP:0002367)5.14313572
5Focal motor seizures (HP:0011153)4.98723046
6Focal seizures (HP:0007359)4.97161514
7Febrile seizures (HP:0002373)4.96686684
8Progressive external ophthalmoplegia (HP:0000590)4.92845169
9Myokymia (HP:0002411)4.73661096
10Microvesicular hepatic steatosis (HP:0001414)4.70336790
11Gaze-evoked nystagmus (HP:0000640)4.61045722
12Dysdiadochokinesis (HP:0002075)4.58696085
13Atonic seizures (HP:0010819)4.52501932
14Congenital stationary night blindness (HP:0007642)4.32896426
15Abnormality of the lower motor neuron (HP:0002366)4.25552091
16Scanning speech (HP:0002168)4.23075352
17Chronic sinusitis (HP:0011109)4.12193124
18Epileptic encephalopathy (HP:0200134)4.07393479
19Hemiplegia (HP:0002301)4.03709351
20Hemiparesis (HP:0001269)4.00374439
21Tubulointerstitial nephritis (HP:0001970)3.98760449
22Hypoproteinemia (HP:0003075)3.94176009
23Impaired smooth pursuit (HP:0007772)3.91706520
24Dysmetric saccades (HP:0000641)3.90261295
25Intention tremor (HP:0002080)3.87273632
26Abnormality of ocular smooth pursuit (HP:0000617)3.79016791
27Genetic anticipation (HP:0003743)3.76774196
28Absence seizures (HP:0002121)3.70526357
29Broad-based gait (HP:0002136)3.45548108
30Dysmetria (HP:0001310)3.44996148
31Diplopia (HP:0000651)3.43272209
32Abnormality of binocular vision (HP:0011514)3.43272209
33Horizontal nystagmus (HP:0000666)3.36047226
34Cellulitis (HP:0100658)3.34803773
35Goiter (HP:0000853)3.32589667
36Dialeptic seizures (HP:0011146)3.32396888
37Generalized tonic-clonic seizures (HP:0002069)3.31684849
38Persistence of primary teeth (HP:0006335)3.23386002
39Tetraplegia (HP:0002445)3.21080142
40Annular pancreas (HP:0001734)3.18063172
41Stridor (HP:0010307)3.17415841
42Truncal ataxia (HP:0002078)3.16941410
43Steatorrhea (HP:0002570)3.12782386
44Carpal bone hypoplasia (HP:0001498)3.12411061
45Prostate neoplasm (HP:0100787)3.10885376
46Status epilepticus (HP:0002133)3.05534689
47Rough bone trabeculation (HP:0100670)2.97822564
48External ophthalmoplegia (HP:0000544)2.94358952
49Gout (HP:0001997)2.93903311
50Chronic obstructive pulmonary disease (HP:0006510)2.90627608
51Obstructive lung disease (HP:0006536)2.90627608
52Neoplasm of the heart (HP:0100544)2.85266773
53Postural tremor (HP:0002174)2.81993901
54Recurrent bronchitis (HP:0002837)2.81787621
55Abnormality of the middle phalanges of the toes (HP:0010183)2.81027493
56Bronchomalacia (HP:0002780)2.78074781
57Poor eye contact (HP:0000817)2.77106810
58Glucose intolerance (HP:0000833)2.74969855
59Abnormality of B cell number (HP:0010975)2.71204485
60Muscle fiber splitting (HP:0003555)2.71013557
61Exocrine pancreatic insufficiency (HP:0001738)2.69501601
62Supranuclear gaze palsy (HP:0000605)2.67916125
63Abnormality of the corticospinal tract (HP:0002492)2.65883140
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.64010814
65Apathy (HP:0000741)2.63862455
66Ventricular fibrillation (HP:0001663)2.63485687
67Depressed nasal tip (HP:0000437)2.62643669
68Abnormal social behavior (HP:0012433)2.57779288
69Impaired social interactions (HP:0000735)2.57779288
70Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.57624146
71Abnormality of the prostate (HP:0008775)2.55478731
72Agitation (HP:0000713)2.55196282
73Depression (HP:0000716)2.51601545
74Verrucae (HP:0200043)2.51557756
75Papilloma (HP:0012740)2.51557756
76Recurrent pneumonia (HP:0006532)2.51117046
77Nonprogressive disorder (HP:0003680)2.48545880
78Abnormality of saccadic eye movements (HP:0000570)2.47529428
79Flat acetabular roof (HP:0003180)2.45939362
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45872888
81Dicarboxylic aciduria (HP:0003215)2.45872888
82Diminished motivation (HP:0000745)2.45385287
83Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44045489
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44045489
85Meningitis (HP:0001287)2.43884999
86Autoimmune thrombocytopenia (HP:0001973)2.42418416
87Amyotrophic lateral sclerosis (HP:0007354)2.40179750
88B lymphocytopenia (HP:0010976)2.37943038
89Seborrheic dermatitis (HP:0001051)2.37177644
90Sepsis (HP:0100806)2.36282385
91Hyperventilation (HP:0002883)2.34284606
92Progressive muscle weakness (HP:0003323)2.33227302
93Limb ataxia (HP:0002070)2.32534881
94Morphological abnormality of the pyramidal tract (HP:0002062)2.29546900
95Oligodactyly (hands) (HP:0001180)2.28788611
96Abnormal glucose tolerance (HP:0001952)2.27183832
97Abnormal trabecular bone morphology (HP:0100671)2.26746837
98Fat malabsorption (HP:0002630)2.25788721
99Bilateral microphthalmos (HP:0007633)2.23774331
100Anxiety (HP:0000739)2.23427934
101J-shaped sella turcica (HP:0002680)2.20277630
102Spinal muscular atrophy (HP:0007269)2.19916005
103Abnormality of male internal genitalia (HP:0000022)2.19767452
104Hyperthyroidism (HP:0000836)2.18867646
105Amblyopia (HP:0000646)2.18360876
106Osteomyelitis (HP:0002754)2.18263174
107Barrel-shaped chest (HP:0001552)2.17883742
108Hand muscle atrophy (HP:0009130)2.17845548
109Increased purine levels (HP:0004368)2.16073125
110Hyperuricemia (HP:0002149)2.16073125
111Ankle clonus (HP:0011448)2.12863094
112Clumsiness (HP:0002312)2.07321998
113Fetal akinesia sequence (HP:0001989)2.04406898
114Down-sloping shoulders (HP:0200021)2.04289296
115Drooling (HP:0002307)2.02608393
116Excessive salivation (HP:0003781)2.02608393
117Abnormal eating behavior (HP:0100738)2.01501735
118Recurrent otitis media (HP:0000403)2.00941560
119Gait ataxia (HP:0002066)2.00828429
120Abnormality of the pleura (HP:0002103)1.97580794
121Spastic gait (HP:0002064)1.97277845
122Aqueductal stenosis (HP:0002410)1.96285049
123Postural instability (HP:0002172)1.93954095
124Aplasia involving bones of the extremities (HP:0009825)1.90064703
125Aplasia involving bones of the upper limbs (HP:0009823)1.90064703
126Aplasia of the phalanges of the hand (HP:0009802)1.90064703
127Poikiloderma (HP:0001029)1.89903598
128Athetosis (HP:0002305)1.89284828
129Myotonia (HP:0002486)1.88296270
130Urinary bladder sphincter dysfunction (HP:0002839)1.86647041
131Pointed chin (HP:0000307)1.86592071
132Sleep apnea (HP:0010535)1.85756944
133Mutism (HP:0002300)1.84910899
134Pancreatitis (HP:0001733)1.84752605
135Hyperphosphatemia (HP:0002905)1.84680634
136Abnormality of the columella (HP:0009929)1.84409223
137Neuronal loss in central nervous system (HP:0002529)1.84374573
138Stereotypic behavior (HP:0000733)1.83914825
139Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.82997733
140Spastic tetraparesis (HP:0001285)1.82570428
141Renal salt wasting (HP:0000127)1.82240170
142Dyskinesia (HP:0100660)1.82226371
143Hypoplasia of the odontoid process (HP:0003311)1.82137776
144Absent speech (HP:0001344)1.81760277
145Clonus (HP:0002169)1.80419390
146Failure to thrive in infancy (HP:0001531)1.79817670
147Panhypogammaglobulinemia (HP:0003139)1.79694496
148Tracheomalacia (HP:0002779)1.79525522
149Severe combined immunodeficiency (HP:0004430)1.78782562
150Dysautonomia (HP:0002459)1.78201278
151Diaphragmatic weakness (HP:0009113)1.76940469
152Macroorchidism (HP:0000053)1.76789095
153Loss of speech (HP:0002371)1.75504056
154Delayed CNS myelination (HP:0002188)1.74962274
155Dysphonia (HP:0001618)1.74688243
156Hypochromic microcytic anemia (HP:0004840)1.72931956
157Insomnia (HP:0100785)1.72867687
158Slow progression (HP:0003677)1.71081961
159Psychosis (HP:0000709)1.70341876
160Hypoplastic nipples (HP:0002557)1.69779720
161Upper limb amyotrophy (HP:0009129)1.69312467
162Distal upper limb amyotrophy (HP:0007149)1.69312467
163Obstructive sleep apnea (HP:0002870)1.68379034
164EEG with generalized epileptiform discharges (HP:0011198)1.65463382
165Hepatoblastoma (HP:0002884)1.63162788
166Generalized hypotonia (HP:0001290)1.62866755
167Incomplete penetrance (HP:0003829)1.61642434
168Astrocytoma (HP:0009592)1.61398326
169Abnormality of the astrocytes (HP:0100707)1.61398326
170Turricephaly (HP:0000262)1.60935126
171Epileptiform EEG discharges (HP:0011182)1.60025539
172Impaired vibration sensation in the lower limbs (HP:0002166)1.59205637
173Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.57634716
174Narrow nasal bridge (HP:0000446)1.53913892
175Generalized myoclonic seizures (HP:0002123)1.52359091
176Abnormal EKG (HP:0003115)1.52222342
177Spinal canal stenosis (HP:0003416)1.51342601
178Confusion (HP:0001289)1.49777684
179Abnormality of the salivary glands (HP:0010286)1.49604289
180Malignant neoplasm of the central nervous system (HP:0100836)1.49467239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.38256336
2RIPK13.25315731
3MAP3K93.03052096
4CAMKK22.85988284
5NTRK22.85506199
6WNK12.74886340
7MAPKAPK32.67778466
8TYRO32.47886385
9GRK52.47755895
10MAP3K42.35734890
11PAK62.26619853
12STK382.19690551
13NTRK12.16847219
14CAMKK12.15901536
15MARK12.15113234
16MINK12.13873018
17TESK210.7871073
18MAP2K41.92319673
19UHMK11.73952172
20INSRR1.70403874
21ARAF1.65747712
22PRPF4B1.53318275
23SIK21.47108054
24MAP2K71.46485479
25DAPK21.43072716
26CDK121.42954767
27CDK191.42575436
28ICK1.33461823
29CAMK41.32874410
30TNIK1.31089327
31ALK1.31005207
32CDC42BPA1.28734964
33PRKCG1.27540958
34DDR21.27164096
35STK111.20704965
36PINK11.18191598
37PHKG21.17512992
38PHKG11.17512992
39EEF2K1.13373025
40CAMK1G1.12893834
41CAMK11.12748753
42VRK21.12611562
43RIPK41.10296215
44CDK51.09113928
45PKN21.08100465
46HIPK21.07601147
47ITK1.05824794
48PNCK1.05722653
49KDR1.05564189
50MARK21.05058999
51MATK1.04460734
52SGK4941.04130420
53SGK2231.04130420
54ERN11.00326854
55LATS21.00322955
56BMX0.97327030
57MAP3K130.96616466
58PDGFRA0.95796734
59PRKCH0.95704454
60PBK0.94530293
61FER0.93331240
62CDK150.93279755
63SGK20.90797421
64SGK30.90052884
65SIK30.89217815
66CDK180.88384965
67MAPK110.88336491
68IKBKB0.86926666
69MAPK130.85811777
70DYRK30.84829236
71DYRK1A0.84697098
72CDK11A0.83028260
73PIM20.82566390
74OXSR10.82504599
75TRIB30.76119649
76MAP3K60.75509887
77MAP2K20.75021753
78ZAP700.74673402
79TNK20.73076355
80SYK0.72362730
81CDK140.71699508
82PRKD30.71430530
83PTK20.69258129
84MST40.67996737
85SRPK10.66976914
86MAPK100.66867335
87CAMK2A0.66195826
88RET0.66121194
89KSR20.66046890
90GRK10.65648372
91RPS6KA30.65101712
92SGK10.64728040
93TXK0.64556781
94MAP4K10.64338248
95STK240.64173317
96STK390.63421802
97MAPK70.63017898
98ROCK20.61397363
99FLT30.59967433
100KSR10.59814090
101NEK60.57624696
102MAPKAPK50.57594507
103PRKAA10.57342050
104MAP4K20.56700296
105RPS6KA50.56196686
106PRKD20.55871288
107LMTK20.55710495
108PAK30.54831131
109CAMK2G0.54417118
110TBK10.54081358
111NME20.53963070
112SIK10.53170487
113DAPK10.52741704
114MAPK120.52696767
115PTK60.51909589
116TIE10.49608232
117LYN0.49354269
118CAMK1D0.48986100
119PRKG10.48426011
120EPHA20.47968250
121PRKCI0.47942980
122AKT30.47312377
123PIK3CA0.46508984
124ERBB20.46243034
125BCKDK0.45682905
126CASK0.45161255
127CAMK2D0.44850815
128SMG10.44642110
129GRK70.43708683
130PLK20.43465693
131CAMK2B0.43460964
132MAPK80.43029017
133ADRBK10.42701573
134CCNB10.42297864
135MST1R0.42021025
136FYN0.41412321
137CDK70.40764433
138CSNK1E0.40718172
139PTK2B0.39534851
140MAPK150.39434503
141GSK3B0.39412341
142ADRBK20.39182192
143PRKACA0.38671313
144KIT0.37184087
145RPS6KL10.36987380
146RPS6KC10.36987380
147SCYL20.36934082
148MAPK90.36614652
149GRK60.36053799
150RPS6KA60.35775288
151AKT20.33895685
152BTK0.30205551
153PRKD10.29793657
154ZAK0.28707661
155ATR0.28471875
156MTOR0.27788836
157LRRK20.26143200
158JAK30.22925919
159MAP3K70.22671188
160PRKCD0.22242763
161CLK10.22043791
162EPHA30.20282092
163DYRK1B0.19796928
164CDK90.18913924
165RPS6KA20.18471239

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.14842608
2Nicotine addiction_Homo sapiens_hsa050334.20333336
3Phototransduction_Homo sapiens_hsa047443.47148927
4Glutamatergic synapse_Homo sapiens_hsa047243.03152261
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.02856037
6Primary immunodeficiency_Homo sapiens_hsa053402.86575068
7Asthma_Homo sapiens_hsa053102.76452991
8Synaptic vesicle cycle_Homo sapiens_hsa047212.74757181
9GABAergic synapse_Homo sapiens_hsa047272.74408547
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65497040
11Long-term potentiation_Homo sapiens_hsa047202.62220552
12Circadian entrainment_Homo sapiens_hsa047132.57637965
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.54353565
14Long-term depression_Homo sapiens_hsa047302.52002543
15Salivary secretion_Homo sapiens_hsa049702.37506285
16Taste transduction_Homo sapiens_hsa047422.35100677
17Other glycan degradation_Homo sapiens_hsa005112.29447420
18Morphine addiction_Homo sapiens_hsa050322.23511235
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21700174
20Graft-versus-host disease_Homo sapiens_hsa053322.19492791
21Autoimmune thyroid disease_Homo sapiens_hsa053201.97932147
22Amphetamine addiction_Homo sapiens_hsa050311.90962589
23Gastric acid secretion_Homo sapiens_hsa049711.85738673
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85589285
25Protein digestion and absorption_Homo sapiens_hsa049741.82587343
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82310280
27Allograft rejection_Homo sapiens_hsa053301.79233257
28Olfactory transduction_Homo sapiens_hsa047401.73683067
29Insulin secretion_Homo sapiens_hsa049111.72099806
30Dopaminergic synapse_Homo sapiens_hsa047281.70245436
31Type I diabetes mellitus_Homo sapiens_hsa049401.69077417
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64282828
33Cholinergic synapse_Homo sapiens_hsa047251.58997723
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.57006535
35Oxytocin signaling pathway_Homo sapiens_hsa049211.55381483
36GnRH signaling pathway_Homo sapiens_hsa049121.52297598
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.49089886
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48918780
39Calcium signaling pathway_Homo sapiens_hsa040201.47982262
40Serotonergic synapse_Homo sapiens_hsa047261.47519486
41Type II diabetes mellitus_Homo sapiens_hsa049301.44312364
42Antigen processing and presentation_Homo sapiens_hsa046121.43887025
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42234132
44Estrogen signaling pathway_Homo sapiens_hsa049151.37171736
45Renin secretion_Homo sapiens_hsa049241.35529085
46Gap junction_Homo sapiens_hsa045401.33500112
47cAMP signaling pathway_Homo sapiens_hsa040241.31446617
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27417737
49Systemic lupus erythematosus_Homo sapiens_hsa053221.26426980
50Regulation of autophagy_Homo sapiens_hsa041401.20507477
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17339202
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16438108
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.16050729
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16041928
55Pancreatic secretion_Homo sapiens_hsa049721.14768353
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10414756
57Cocaine addiction_Homo sapiens_hsa050301.09608193
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.08390782
59Peroxisome_Homo sapiens_hsa041461.03008319
60Pentose phosphate pathway_Homo sapiens_hsa000301.01248175
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01239522
62Influenza A_Homo sapiens_hsa051641.00312159
63Thyroid hormone synthesis_Homo sapiens_hsa049181.00178958
64Inositol phosphate metabolism_Homo sapiens_hsa005620.99571064
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.98574701
66Rheumatoid arthritis_Homo sapiens_hsa053230.94627183
67Staphylococcus aureus infection_Homo sapiens_hsa051500.93805092
68Choline metabolism in cancer_Homo sapiens_hsa052310.93494640
69Arachidonic acid metabolism_Homo sapiens_hsa005900.92140255
70Cardiac muscle contraction_Homo sapiens_hsa042600.91776388
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91650086
72Hedgehog signaling pathway_Homo sapiens_hsa043400.88490576
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88478172
74ErbB signaling pathway_Homo sapiens_hsa040120.88081344
75Bile secretion_Homo sapiens_hsa049760.88033998
76Melanogenesis_Homo sapiens_hsa049160.87887371
77Dorso-ventral axis formation_Homo sapiens_hsa043200.86664930
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84523863
79Alcoholism_Homo sapiens_hsa050340.84112644
80Sulfur relay system_Homo sapiens_hsa041220.83414773
81Fatty acid biosynthesis_Homo sapiens_hsa000610.83299626
82Axon guidance_Homo sapiens_hsa043600.83217300
83Dilated cardiomyopathy_Homo sapiens_hsa054140.82383683
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81774088
85mTOR signaling pathway_Homo sapiens_hsa041500.81284488
86MAPK signaling pathway_Homo sapiens_hsa040100.80049903
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77269188
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76679504
89Oocyte meiosis_Homo sapiens_hsa041140.76558828
90Linoleic acid metabolism_Homo sapiens_hsa005910.74919120
91Ovarian steroidogenesis_Homo sapiens_hsa049130.74343492
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73157045
93Fatty acid elongation_Homo sapiens_hsa000620.72254381
94Retinol metabolism_Homo sapiens_hsa008300.71099911
95Nitrogen metabolism_Homo sapiens_hsa009100.71000557
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.70852772
97Circadian rhythm_Homo sapiens_hsa047100.70816516
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70577246
99Hematopoietic cell lineage_Homo sapiens_hsa046400.67292726
100Glioma_Homo sapiens_hsa052140.66302075
101Notch signaling pathway_Homo sapiens_hsa043300.64956664
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64366933
103Ether lipid metabolism_Homo sapiens_hsa005650.62992271
104Glutathione metabolism_Homo sapiens_hsa004800.62066044
105Lysosome_Homo sapiens_hsa041420.61637863
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61042413
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58327427
108Leishmaniasis_Homo sapiens_hsa051400.56929327
109Rap1 signaling pathway_Homo sapiens_hsa040150.55736775
110Hepatitis C_Homo sapiens_hsa051600.54654576
111VEGF signaling pathway_Homo sapiens_hsa043700.54126414
112Collecting duct acid secretion_Homo sapiens_hsa049660.53374898
113Wnt signaling pathway_Homo sapiens_hsa043100.53191627
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.52276548
115B cell receptor signaling pathway_Homo sapiens_hsa046620.48510108
116Viral myocarditis_Homo sapiens_hsa054160.46343155
117Fructose and mannose metabolism_Homo sapiens_hsa000510.45003843
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.44754704
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44664104
120Basal cell carcinoma_Homo sapiens_hsa052170.44645305
121Ras signaling pathway_Homo sapiens_hsa040140.44237356
122ABC transporters_Homo sapiens_hsa020100.44026938
123Lysine degradation_Homo sapiens_hsa003100.42499181
124Mineral absorption_Homo sapiens_hsa049780.39992036
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.39833521
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39107271
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.38644007
128Renin-angiotensin system_Homo sapiens_hsa046140.38545766
129Endocytosis_Homo sapiens_hsa041440.37407099
130Hippo signaling pathway_Homo sapiens_hsa043900.36910835
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36719179
132Proteoglycans in cancer_Homo sapiens_hsa052050.36219420
133Herpes simplex infection_Homo sapiens_hsa051680.35974982
134Non-homologous end-joining_Homo sapiens_hsa034500.34757527
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34710550
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34273867
137Endometrial cancer_Homo sapiens_hsa052130.34023696
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33874536
139African trypanosomiasis_Homo sapiens_hsa051430.33696283
140Tight junction_Homo sapiens_hsa045300.33577131
141Glucagon signaling pathway_Homo sapiens_hsa049220.31849039
142Platelet activation_Homo sapiens_hsa046110.31806114
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31683323
144Vibrio cholerae infection_Homo sapiens_hsa051100.31602629
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.30537057
146Vitamin B6 metabolism_Homo sapiens_hsa007500.30507353
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29231674
148Arginine biosynthesis_Homo sapiens_hsa002200.26849302
149Chemokine signaling pathway_Homo sapiens_hsa040620.26395274
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20969790
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18788840
152N-Glycan biosynthesis_Homo sapiens_hsa005100.15119241

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