GRHL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)7.51850017
2keratinocyte differentiation (GO:0030216)7.44217846
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.76161849
4intermediate filament organization (GO:0045109)6.65271413
5sphingoid metabolic process (GO:0046519)6.34699069
6water homeostasis (GO:0030104)6.32613836
7peptide cross-linking (GO:0018149)6.08243958
8epidermal cell differentiation (GO:0009913)5.84002173
9hemidesmosome assembly (GO:0031581)5.66752239
10epidermis development (GO:0008544)5.52473664
11keratinocyte proliferation (GO:0043616)5.50600401
12sphingosine metabolic process (GO:0006670)5.50226901
13keratinocyte development (GO:0003334)5.24961045
14diol metabolic process (GO:0034311)5.08426095
15long-chain fatty acid biosynthetic process (GO:0042759)4.79584345
16interferon-gamma secretion (GO:0072643)4.60977619
17glucosamine-containing compound catabolic process (GO:1901072)4.56570137
18ectoderm development (GO:0007398)4.45324331
19intermediate filament cytoskeleton organization (GO:0045104)4.31901030
20regulation of ruffle assembly (GO:1900027)4.28113948
21intermediate filament-based process (GO:0045103)4.19037096
22regulation of cell proliferation involved in kidney development (GO:1901722)4.08568683
23regulation of phospholipase A2 activity (GO:0032429)4.01861014
24skin morphogenesis (GO:0043589)3.97098350
25polarized epithelial cell differentiation (GO:0030859)3.91559132
26fatty acid elongation (GO:0030497)3.90223211
27regulation of transforming growth factor beta1 production (GO:0032908)3.79188933
28phosphatidylinositol acyl-chain remodeling (GO:0036149)3.77399730
29negative regulation of keratinocyte proliferation (GO:0010839)3.62823147
30virion attachment to host cell (GO:0019062)3.56151032
31adhesion of symbiont to host cell (GO:0044650)3.56151032
32regulation of chemokine secretion (GO:0090196)3.54380132
33detection of bacterium (GO:0016045)3.47399704
34linoleic acid metabolic process (GO:0043651)3.43798335
35positive regulation of interleukin-8 secretion (GO:2000484)3.26492061
36chemical homeostasis within a tissue (GO:0048875)3.23838593
37intestinal epithelial cell development (GO:0060576)3.22565903
38phospholipid scrambling (GO:0017121)3.22015056
39long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.16618119
40phosphatidylserine acyl-chain remodeling (GO:0036150)3.13215776
41positive regulation of meiotic cell cycle (GO:0051446)3.12858881
42positive regulation of vesicle fusion (GO:0031340)3.11903910
43regulation of glomerular filtration (GO:0003093)3.10150288
44gland morphogenesis (GO:0022612)3.09408794
45multicellular organism reproduction (GO:0032504)3.07923321
46negative regulation of cell fate specification (GO:0009996)3.07635129
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07601497
48negative regulation of stress fiber assembly (GO:0051497)3.05760932
49fusion of sperm to egg plasma membrane (GO:0007342)3.03640573
50phospholipid catabolic process (GO:0009395)3.01847030
51phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.01652033
52axoneme assembly (GO:0035082)3.00996667
53G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.98776212
54cilium movement (GO:0003341)2.94805370
55cilium or flagellum-dependent cell motility (GO:0001539)2.94749770
56cardiac right ventricle morphogenesis (GO:0003215)2.93575799
57positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.92627412
58regulation of cardioblast differentiation (GO:0051890)2.91314883
59epithelial cilium movement (GO:0003351)2.90588487
60detection of other organism (GO:0098543)2.90337486
61regulation of keratinocyte differentiation (GO:0045616)2.87602491
62axonemal dynein complex assembly (GO:0070286)2.86498341
63epithelial cell-cell adhesion (GO:0090136)2.83692553
64regulation of cardioblast proliferation (GO:0003264)2.82977937
65regulation of secondary heart field cardioblast proliferation (GO:0003266)2.82977937
66notochord development (GO:0030903)2.82763291
67prostanoid biosynthetic process (GO:0046457)2.81827375
68prostaglandin biosynthetic process (GO:0001516)2.81827375
69ventricular cardiac muscle cell action potential (GO:0086005)2.80586825
70response to pheromone (GO:0019236)2.77234350
71transepithelial transport (GO:0070633)2.76984496
72phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.76773679
73regulation of hypersensitivity (GO:0002883)2.76238932
74epithelium development (GO:0060429)2.76219939
75cellular biogenic amine catabolic process (GO:0042402)2.73605222
76amine catabolic process (GO:0009310)2.73605222
77establishment of protein localization to Golgi (GO:0072600)2.72220379
78magnesium ion transport (GO:0015693)2.71791818
79chemosensory behavior (GO:0007635)2.71345518
80estrogen biosynthetic process (GO:0006703)2.71134637
81adhesion of symbiont to host (GO:0044406)2.70876558
82positive regulation of glomerulus development (GO:0090193)2.69654395
83hair follicle morphogenesis (GO:0031069)2.69412052
84phenylpropanoid metabolic process (GO:0009698)2.68914025
85positive regulation of hair follicle development (GO:0051798)2.68708180
86positive regulation of hair cycle (GO:0042635)2.68708180
87positive regulation of Cdc42 GTPase activity (GO:0043089)2.68278859
88regulation of cilium movement (GO:0003352)2.67784339
89negative regulation of cell fate commitment (GO:0010454)2.67536459
90retinol metabolic process (GO:0042572)2.66022134
91L-fucose catabolic process (GO:0042355)2.65633559
92fucose catabolic process (GO:0019317)2.65633559
93L-fucose metabolic process (GO:0042354)2.65633559
94hair follicle development (GO:0001942)2.65450389
95phosphatidylcholine acyl-chain remodeling (GO:0036151)2.65203691
96positive regulation of chemokine secretion (GO:0090197)2.63398402
97molting cycle process (GO:0022404)2.62493490
98hair cycle process (GO:0022405)2.62493490
99photoreceptor cell maintenance (GO:0045494)2.62469226
100regulation of integrin-mediated signaling pathway (GO:2001044)2.62402060
101atrioventricular valve morphogenesis (GO:0003181)2.62216504
102piRNA metabolic process (GO:0034587)2.62122301
103pharyngeal system development (GO:0060037)2.62004428
104negative regulation of kidney development (GO:0090185)2.61926102
105regulation of Cdc42 GTPase activity (GO:0043088)2.59973091
106cellular response to interferon-alpha (GO:0035457)2.58757944
107regulation of natural killer cell differentiation (GO:0032823)2.58613368
108protein targeting to Golgi (GO:0000042)2.57978640
109DNA methylation involved in gamete generation (GO:0043046)2.57613448
110lipoxygenase pathway (GO:0019372)2.57171538
111regulation of interleukin-8 secretion (GO:2000482)2.56982872
112thyroid hormone generation (GO:0006590)2.56848392
113positive regulation of epidermis development (GO:0045684)2.55222857
114phosphatidylserine metabolic process (GO:0006658)2.54363709
115sperm motility (GO:0030317)2.54009481
116prostate gland growth (GO:0060736)2.53914187
117genitalia morphogenesis (GO:0035112)2.53520942
118hair cell differentiation (GO:0035315)2.52788944
119cornea development in camera-type eye (GO:0061303)2.52362297
120regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.51039996
121gap junction assembly (GO:0016264)2.50909974
122retrograde transport, vesicle recycling within Golgi (GO:0000301)2.49584093
123sphingolipid biosynthetic process (GO:0030148)2.48861249
124establishment of tissue polarity (GO:0007164)2.48352923
125establishment of planar polarity (GO:0001736)2.48352923
126ephrin receptor signaling pathway (GO:0048013)2.48081855
127negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.46789840
128regulation of epidermis development (GO:0045682)2.46749934
129positive regulation of monocyte chemotaxis (GO:0090026)2.46420296
130thyroid hormone metabolic process (GO:0042403)2.44370408
131regulation of keratinocyte proliferation (GO:0010837)2.43789708
132cell wall macromolecule metabolic process (GO:0044036)2.43396228
133cell wall macromolecule catabolic process (GO:0016998)2.43396228
134oocyte development (GO:0048599)2.42077632
135phospholipid homeostasis (GO:0055091)2.42027302
136outflow tract septum morphogenesis (GO:0003148)2.41851559
137phosphatidylglycerol metabolic process (GO:0046471)2.41781306
138detection of light stimulus involved in sensory perception (GO:0050962)2.41407869
139detection of light stimulus involved in visual perception (GO:0050908)2.41407869
140cellular ketone body metabolic process (GO:0046950)2.40520323
141regulation of heart rate by cardiac conduction (GO:0086091)2.40279432
142renal system process involved in regulation of blood volume (GO:0001977)2.39961099
143xenobiotic catabolic process (GO:0042178)2.38131885
144tight junction assembly (GO:0070830)2.35322231
145phosphatidylcholine metabolic process (GO:0046470)2.33267638
146regulation of protein localization to cell surface (GO:2000008)2.32826912
147protein neddylation (GO:0045116)2.30799163
148calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.30094902
149regulation of clathrin-mediated endocytosis (GO:2000369)2.29407913
150positive regulation of epidermal cell differentiation (GO:0045606)2.28018151
151S-adenosylmethionine metabolic process (GO:0046500)2.27618277
152desmosome organization (GO:0002934)14.5410904
153establishment of skin barrier (GO:0061436)11.6946744
154regulation of water loss via skin (GO:0033561)10.7730918
155keratinization (GO:0031424)10.7686868
156hair cycle (GO:0042633)10.1500519
157molting cycle (GO:0042303)10.1500519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.68171123
2P63_26484246_Chip-Seq_KERATINOCYTES_Human2.63689571
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.34976434
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.14841218
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.12572381
6* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.12541442
7ZNF274_21170338_ChIP-Seq_K562_Hela2.02492185
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.5780732
9POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92673755
10FOXO3_23340844_ChIP-Seq_DLD1_Human1.90994989
11AR_21572438_ChIP-Seq_LNCaP_Human1.88978631
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79044464
13TAF15_26573619_Chip-Seq_HEK293_Human1.77981464
14GBX2_23144817_ChIP-Seq_PC3_Human1.71506224
15ZNF263_19887448_ChIP-Seq_K562_Human1.70516281
16ER_23166858_ChIP-Seq_MCF-7_Human1.69311254
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67808341
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67808341
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62520094
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.59796743
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59175145
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58878670
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.54797423
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53774956
25TP63_23658742_ChIP-Seq_EP156T_Human1.52471038
26TP53_18474530_ChIP-ChIP_U2OS_Human1.52031487
27CBP_20019798_ChIP-Seq_JUKART_Human1.51360257
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51360257
29HTT_18923047_ChIP-ChIP_STHdh_Human1.50905117
30FUS_26573619_Chip-Seq_HEK293_Human1.50572755
31IGF1R_20145208_ChIP-Seq_DFB_Human1.49165984
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47461373
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41332725
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40871215
35* SOX2_20726797_ChIP-Seq_SW620_Human1.40522276
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.40295758
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40295758
38KLF5_25053715_ChIP-Seq_YYC3_Human1.37442439
39* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37344738
40RXR_22108803_ChIP-Seq_LS180_Human1.37300749
41P300_19829295_ChIP-Seq_ESCs_Human1.35438196
42* AHR_22903824_ChIP-Seq_MCF-7_Human1.34130613
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.33810458
44HOXB7_26014856_ChIP-Seq_BT474_Human1.32774918
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30919568
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28638204
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.27181409
48ERG_20517297_ChIP-Seq_VCAP_Human1.26173948
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24424335
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.23543841
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23440408
52AR_20517297_ChIP-Seq_VCAP_Human1.22652435
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22291995
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22022942
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21620986
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.21324374
57GATA4_25053715_ChIP-Seq_YYC3_Human1.19538676
58* FOXA1_25552417_ChIP-Seq_VCAP_Human1.19071688
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18906106
60CJUN_26792858_Chip-Seq_BT549_Human1.18887416
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17198849
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16779093
63* ARNT_22903824_ChIP-Seq_MCF-7_Human1.16691317
64BCAT_22108803_ChIP-Seq_LS180_Human1.15940857
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.15662137
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.15612225
67* GATA3_24758297_ChIP-Seq_MCF-7_Human1.15239706
68TCF4_23295773_ChIP-Seq_U87_Human1.14692616
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13845220
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13745261
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13745261
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13307903
73STAT3_23295773_ChIP-Seq_U87_Human1.13299068
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13149456
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12188033
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.11825191
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.11718309
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10870266
79SOX2_19829295_ChIP-Seq_ESCs_Human1.10408117
80NANOG_19829295_ChIP-Seq_ESCs_Human1.10408117
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09919066
82* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08029290
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.05879008
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.05540043
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.05001339
86TBL1_22424771_ChIP-Seq_293T_Human1.04799405
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04221601
88* TP63_22573176_ChIP-Seq_HFKS_Human1.03741947
89HNFA_21074721_ChIP-Seq_CACO-2_Human1.03596196
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.03419638
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02466094
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02438770
93EZH2_27304074_Chip-Seq_ESCs_Mouse1.02198269
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01663766
95* ETV1_20927104_ChIP-Seq_GIST48_Human1.01187102
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.01178650
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00947502
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.00530781
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00310181
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99055836
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96416500
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94991405
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94116845
104EZH2_27294783_Chip-Seq_ESCs_Mouse0.93841576
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93756182
106GATA6_21074721_ChIP-Seq_CACO-2_Human0.91758147
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91733355
108VDR_22108803_ChIP-Seq_LS180_Human0.91391332
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90985859
110SMAD_19615063_ChIP-ChIP_OVARY_Human0.90553007
111SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90447879
112JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90172349
113P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89320566
114TCF4_22108803_ChIP-Seq_LS180_Human0.88484066
115SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88427625
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87490606
117AR_25329375_ChIP-Seq_VCAP_Human0.87094520
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.86887783
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86532940
120GATA6_25053715_ChIP-Seq_YYC3_Human0.86434296
121RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86189063
122EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86189063
123* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85800157
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85222071
125CBX2_27304074_Chip-Seq_ESCs_Mouse0.84418690
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83982397
127CEBPB_22108803_ChIP-Seq_LS180_Human0.83822817
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.82070340
129* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82044939
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80627429
131TP53_20018659_ChIP-ChIP_R1E_Mouse0.80546091
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.79381904
133* RBPJ_21746931_ChIP-Seq_IB4_Human0.79144260
134* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79011403
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.78884155
136CDX2_22108803_ChIP-Seq_LS180_Human0.78614587
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78267984
138RACK7_27058665_Chip-Seq_MCF-7_Human0.77009840
139JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74344456
140HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74282171
141TP53_16413492_ChIP-PET_HCT116_Human0.73136379
142IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73003441
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.72554634
144OCT1_27270436_Chip-Seq_PROSTATE_Human0.72203188
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71685234
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.71058269
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.70039253
148SMAD4_21799915_ChIP-Seq_A2780_Human0.69949491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.70268301
2MP0010234_abnormal_vibrissa_follicle6.29936261
3MP0005275_abnormal_skin_tensile4.84937090
4MP0000579_abnormal_nail_morphology4.66565731
5MP0005501_abnormal_skin_physiology4.56085682
6MP0003941_abnormal_skin_development4.54676903
7MP0002098_abnormal_vibrissa_morphology3.84954718
8MP0004381_abnormal_hair_follicle3.68334565
9MP0010678_abnormal_skin_adnexa3.60306645
10MP0000383_abnormal_hair_follicle3.47773714
11MP0002254_reproductive_system_inflammat3.32995636
12MP0000647_abnormal_sebaceous_gland3.21168943
13* MP0001216_abnormal_epidermal_layer3.19254732
14MP0002060_abnormal_skin_morphology2.90922633
15MP0010771_integument_phenotype2.86247127
16MP0003453_abnormal_keratinocyte_physiol2.73374387
17MP0000427_abnormal_hair_cycle2.72324900
18MP0000566_synostosis2.67841512
19MP0005451_abnormal_body_composition2.63509894
20MP0004947_skin_inflammation2.46441152
21* MP0000377_abnormal_hair_follicle2.44736537
22MP0001346_abnormal_lacrimal_gland2.27920309
23MP0000467_abnormal_esophagus_morphology2.14635052
24MP0002009_preneoplasia2.03468852
25MP0000762_abnormal_tongue_morphology1.97473148
26MP0003566_abnormal_cell_adhesion1.80096390
27MP0003705_abnormal_hypodermis_morpholog1.67191209
28MP0008875_abnormal_xenobiotic_pharmacok1.55406202
29MP0009931_abnormal_skin_appearance1.50380912
30MP0002234_abnormal_pharynx_morphology1.48715272
31MP0001191_abnormal_skin_condition1.48253544
32MP0005646_abnormal_pituitary_gland1.46991522
33MP0005410_abnormal_fertilization1.43870516
34MP0003718_maternal_effect1.37849082
35* MP0000367_abnormal_coat/_hair1.35774717
36MP0004185_abnormal_adipocyte_glucose1.32184195
37MP0003136_yellow_coat_color1.28079656
38MP0001919_abnormal_reproductive_system1.27197457
39MP0004043_abnormal_pH_regulation1.22131271
40MP0001984_abnormal_olfaction1.17495226
41MP0001485_abnormal_pinna_reflex1.16156703
42MP0001188_hyperpigmentation1.14887230
43MP0003195_calcinosis1.13385378
44MP0001243_abnormal_dermal_layer1.12062681
45MP0004264_abnormal_extraembryonic_tissu1.11586746
46MP0002876_abnormal_thyroid_physiology1.10556183
47MP0008872_abnormal_physiological_respon1.08401073
48MP0002095_abnormal_skin_pigmentation1.04882765
49MP0010329_abnormal_lipoprotein_level1.03817102
50MP0000627_abnormal_mammary_gland1.01932048
51MP0005551_abnormal_eye_electrophysiolog1.00766272
52MP0006072_abnormal_retinal_apoptosis1.00703437
53MP0005365_abnormal_bile_salt0.99970289
54MP0010386_abnormal_urinary_bladder0.96750813
55MP0002006_tumorigenesis0.94151785
56MP0003950_abnormal_plasma_membrane0.91361667
57MP0002160_abnormal_reproductive_system0.90015436
58MP0005310_abnormal_salivary_gland0.89067424
59MP0002909_abnormal_adrenal_gland0.88217195
60MP0001851_eye_inflammation0.87393984
61MP0002653_abnormal_ependyma_morphology0.87001032
62MP0005253_abnormal_eye_physiology0.86308160
63MP0005389_reproductive_system_phenotype0.85810718
64MP0005076_abnormal_cell_differentiation0.85579784
65MP0001340_abnormal_eyelid_morphology0.84851702
66MP0008877_abnormal_DNA_methylation0.84352269
67MP0004782_abnormal_surfactant_physiolog0.82674613
68MP0003638_abnormal_response/metabolism_0.82430057
69MP0000631_abnormal_neuroendocrine_gland0.82051784
70MP0001756_abnormal_urination0.81937590
71MP0008995_early_reproductive_senescence0.79334353
72MP0001881_abnormal_mammary_gland0.78793989
73MP0005636_abnormal_mineral_homeostasis0.77358183
74MP0010352_gastrointestinal_tract_polyps0.76181156
75MP0005085_abnormal_gallbladder_physiolo0.73581894
76MP0003698_abnormal_male_reproductive0.72431374
77MP0002166_altered_tumor_susceptibility0.72152665
78MP0002877_abnormal_melanocyte_morpholog0.71012388
79MP0000003_abnormal_adipose_tissue0.68991677
80MP0001929_abnormal_gametogenesis0.68813239
81MP0000613_abnormal_salivary_gland0.67461360
82MP0002249_abnormal_larynx_morphology0.66859805
83MP0006276_abnormal_autonomic_nervous0.66852025
84MP0005409_darkened_coat_color0.66473332
85MP0003191_abnormal_cellular_cholesterol0.66147145
86MP0002138_abnormal_hepatobiliary_system0.63126207
87MP0000516_abnormal_urinary_system0.62313035
88MP0005367_renal/urinary_system_phenotyp0.62313035
89MP0005645_abnormal_hypothalamus_physiol0.62311090
90MP0009384_cardiac_valve_regurgitation0.62266663
91MP0002736_abnormal_nociception_after0.60831950
92MP0008789_abnormal_olfactory_epithelium0.59758186
93MP0005394_taste/olfaction_phenotype0.58323741
94MP0005499_abnormal_olfactory_system0.58323741
95MP0005464_abnormal_platelet_physiology0.57078794
96MP0005647_abnormal_sex_gland0.55388581
97MP0003878_abnormal_ear_physiology0.55143424
98MP0005377_hearing/vestibular/ear_phenot0.55143424
99MP0005083_abnormal_biliary_tract0.54795039
100MP0003315_abnormal_perineum_morphology0.54768823
101MP0001666_abnormal_nutrient_absorption0.54603139
102MP0004019_abnormal_vitamin_homeostasis0.53473172
103MP0001764_abnormal_homeostasis0.53443787
104MP0002210_abnormal_sex_determination0.53183229
105MP0001968_abnormal_touch/_nociception0.52945811
106MP0000538_abnormal_urinary_bladder0.52802065
107MP0009053_abnormal_anal_canal0.51988622
108MP0000678_abnormal_parathyroid_gland0.51755152
109MP0002090_abnormal_vision0.51686176
110MP0010030_abnormal_orbit_morphology0.51652556
111MP0005379_endocrine/exocrine_gland_phen0.50427847
112MP0005187_abnormal_penis_morphology0.49640327
113MP0002638_abnormal_pupillary_reflex0.49485533
114MP0003755_abnormal_palate_morphology0.48504645
115MP0001784_abnormal_fluid_regulation0.48018771
116MP0008004_abnormal_stomach_pH0.47014273
117MP0000653_abnormal_sex_gland0.46235103
118MP0005408_hypopigmentation0.45930284
119MP0002177_abnormal_outer_ear0.44513520
120MP0004484_altered_response_of0.43031348
121MP0003936_abnormal_reproductive_system0.42698620
122MP0001765_abnormal_ion_homeostasis0.38673735
123MP0005075_abnormal_melanosome_morpholog0.37229071
124MP0005023_abnormal_wound_healing0.35863010
125MP0003045_fibrosis0.35153543
126MP0009379_abnormal_foot_pigmentation0.34735055
127MP0009780_abnormal_chondrocyte_physiolo0.34512874
128MP0003329_amyloid_beta_deposits0.34336447
129MP0004885_abnormal_endolymph0.33350840
130MP0003283_abnormal_digestive_organ0.33345200
131MP0002233_abnormal_nose_morphology0.32929652
132MP0001873_stomach_inflammation0.32661021
133MP0002102_abnormal_ear_morphology0.30008111
134MP0002111_abnormal_tail_morphology0.29678746
135MP0000465_gastrointestinal_hemorrhage0.29665600
136MP0003011_delayed_dark_adaptation0.29377701
137MP0003763_abnormal_thymus_physiology0.29173756
138MP0009250_abnormal_appendicular_skeleto0.28682259
139MP0002282_abnormal_trachea_morphology0.28553859
140MP0005248_abnormal_Harderian_gland0.28169756
141MP0005666_abnormal_adipose_tissue0.27909556
142MP0004858_abnormal_nervous_system0.27591446
143MP0000462_abnormal_digestive_system0.27487772
144MP0000470_abnormal_stomach_morphology0.26864211
145MP0003183_abnormal_peptide_metabolism0.26457947
146MP0000537_abnormal_urethra_morphology0.25358369
147MP0001849_ear_inflammation0.24542612

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)8.11334726
2Woolly hair (HP:0002224)7.34155183
3Abnormality of nail color (HP:0100643)7.06528309
4Right ventricular cardiomyopathy (HP:0011663)6.74549139
5Congenital ichthyosiform erythroderma (HP:0007431)6.44110260
6Increased IgE level (HP:0003212)6.32611954
7Palmoplantar hyperkeratosis (HP:0000972)6.08547245
8Pili torti (HP:0003777)6.07899191
9Plantar hyperkeratosis (HP:0007556)6.07179567
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.77601881
11Palmar hyperkeratosis (HP:0010765)5.71721132
12Lip pit (HP:0100267)5.64211863
13Onycholysis (HP:0001806)5.49981144
14Parakeratosis (HP:0001036)5.28739162
15Erythema (HP:0010783)4.93486945
16Fragile nails (HP:0001808)4.90408022
17Erythroderma (HP:0001019)4.68592902
18Nail dystrophy (HP:0008404)3.99296804
19Oral leukoplakia (HP:0002745)3.92984222
20Natal tooth (HP:0000695)3.87554276
21Milia (HP:0001056)3.74674393
22Corneal erosion (HP:0200020)3.72046253
23Curly hair (HP:0002212)3.60448925
24Abnormal blistering of the skin (HP:0008066)3.58049728
25Hypohidrosis (HP:0000966)3.56027070
26Absent eyelashes (HP:0000561)3.54113746
27Abnormal hair laboratory examination (HP:0003328)3.51457362
28Thick nail (HP:0001805)3.48731754
29Sparse eyelashes (HP:0000653)3.46957089
30Ectropion (HP:0000656)3.45787000
31Brittle hair (HP:0002299)3.41225265
32Conjunctival hamartoma (HP:0100780)3.40776598
33Advanced eruption of teeth (HP:0006288)3.26738663
34Abnormality of secondary sexual hair (HP:0009888)3.22149666
35Abnormality of the axillary hair (HP:0100134)3.22149666
36Sparse scalp hair (HP:0002209)3.16831109
37Palmoplantar keratoderma (HP:0000982)3.10354838
38Ventricular tachycardia (HP:0004756)3.07410522
39Absent hair (HP:0002298)3.05478211
40Alopecia of scalp (HP:0002293)3.03202967
41Popliteal pterygium (HP:0009756)2.99679208
42Gangrene (HP:0100758)2.96530246
43Pruritus (HP:0000989)2.95831432
44Furrowed tongue (HP:0000221)2.90903848
45Distal lower limb muscle weakness (HP:0009053)2.86293543
46Slow-growing hair (HP:0002217)2.82363047
47Abnormality of hair growth rate (HP:0011363)2.82363047
48Acanthosis nigricans (HP:0000956)2.77608643
49Aplasia involving bones of the extremities (HP:0009825)2.75534549
50Aplasia involving bones of the upper limbs (HP:0009823)2.75534549
51Aplasia of the phalanges of the hand (HP:0009802)2.75534549
52Hypoplastic labia majora (HP:0000059)2.65752279
53Abnormality of the salivary glands (HP:0010286)2.39622873
54Abnormality of the labia majora (HP:0012881)2.38765099
55Hyporeflexia of lower limbs (HP:0002600)2.36520371
56Abnormality of the gastric mucosa (HP:0004295)2.35808322
57Oligodontia (HP:0000677)2.33892030
58Follicular hyperkeratosis (HP:0007502)2.31042764
59Aplasia cutis congenita (HP:0001057)2.27945643
60Abnormal ciliary motility (HP:0012262)2.27926091
61Abnormality of the renal cortex (HP:0011035)2.27571192
62Congenital, generalized hypertrichosis (HP:0004540)2.22839018
63Ventricular fibrillation (HP:0001663)2.19330310
64Villous atrophy (HP:0011473)2.18263741
65Abnormality of small intestinal villus morphology (HP:0011472)2.18263741
66Hypergammaglobulinemia (HP:0010702)2.17799470
67Skin pits (HP:0100276)2.15885210
68Blepharitis (HP:0000498)2.10857641
69Congenital malformation of the right heart (HP:0011723)2.10082777
70Double outlet right ventricle (HP:0001719)2.10082777
71Hypoplasia of dental enamel (HP:0006297)2.09247096
72Dry hair (HP:0011359)2.08723489
73Amelogenesis imperfecta (HP:0000705)2.08632649
74Absent eyebrow (HP:0002223)2.06584443
75Concave nail (HP:0001598)2.05994917
76Fair hair (HP:0002286)2.04651579
77Absent/shortened dynein arms (HP:0200106)2.02927648
78Dynein arm defect of respiratory motile cilia (HP:0012255)2.02927648
79Abnormality of dental color (HP:0011073)2.02836891
80Symphalangism affecting the phalanges of the hand (HP:0009773)2.02591135
81Abnormal respiratory epithelium morphology (HP:0012253)2.02179218
82Abnormal respiratory motile cilium morphology (HP:0005938)2.02179218
83Duplicated collecting system (HP:0000081)1.99826410
84Ridged nail (HP:0001807)1.97347933
85Pancreatic cysts (HP:0001737)1.96725889
86Abnormal respiratory motile cilium physiology (HP:0012261)1.94280189
87Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.93588464
88Labial hypoplasia (HP:0000066)1.93455542
89Dehydration (HP:0001944)1.90983456
90Atrophic scars (HP:0001075)1.89790131
91Hamartoma of the eye (HP:0010568)1.89000605
92Abnormality of macular pigmentation (HP:0008002)1.88660063
93Hypoplasia of the uterus (HP:0000013)1.86981656
94Widely spaced teeth (HP:0000687)1.86904031
95Dry skin (HP:0000958)1.86259485
96Menorrhagia (HP:0000132)1.85448766
97Abnormality of the renal collecting system (HP:0004742)1.82831347
98Generalized hypopigmentation of hair (HP:0011358)1.82438949
99Tubulointerstitial nephritis (HP:0001970)1.78997353
100Paralysis (HP:0003470)1.77712981
101Abnormality of the 2nd finger (HP:0004100)1.77196922
102Abnormality of the middle phalanges of the toes (HP:0010183)1.77169278
103Renal cortical cysts (HP:0000803)1.76571699
104Hypoplastic female external genitalia (HP:0012815)1.75938907
105Fine hair (HP:0002213)1.75194645
106Unilateral renal agenesis (HP:0000122)1.74819661
107Corneal dystrophy (HP:0001131)1.74542059
108Hyperlipoproteinemia (HP:0010980)1.74241065
109Bifid scrotum (HP:0000048)1.73735069
110Hypodontia (HP:0000668)1.72451304
111True hermaphroditism (HP:0010459)1.72310502
112Cone-rod dystrophy (HP:0000548)1.71936444
113Abnormal auditory evoked potentials (HP:0006958)1.71127630
114Pterygium (HP:0001059)1.69793649
115Chronic bronchitis (HP:0004469)1.68108954
116Acanthocytosis (HP:0001927)1.67699343
117Laryngomalacia (HP:0001601)1.67398754
118Upper limb muscle weakness (HP:0003484)1.65912879
119Sudden death (HP:0001699)1.65720121
120Depressed nasal tip (HP:0000437)1.65679959
121Abnormality of the renal medulla (HP:0100957)1.64660210
122Aplasia/hypoplasia of the uterus (HP:0008684)1.64445736
123Attenuation of retinal blood vessels (HP:0007843)1.64165764
124Anonychia (HP:0001798)1.61928402
125Azoospermia (HP:0000027)1.59332855
126Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.59221102
127Septate vagina (HP:0001153)1.58830159
128Abnormality of the dental root (HP:0006486)1.58811851
129Taurodontia (HP:0000679)1.58811851
130Abnormality of permanent molar morphology (HP:0011071)1.58811851
131Tubular atrophy (HP:0000092)1.58305217
132Molar tooth sign on MRI (HP:0002419)1.58161918
133Abnormality of midbrain morphology (HP:0002418)1.58161918
134Abnormality of the dental pulp (HP:0006479)1.56771646
135Melanocytic nevus (HP:0000995)1.56054053
136Nephronophthisis (HP:0000090)1.55982756
137Severe Myopia (HP:0011003)1.55971416
138Pancreatic fibrosis (HP:0100732)1.55828336
139Bicornuate uterus (HP:0000813)1.53812617
140Short hallux (HP:0010109)1.52912799
141Abnormality of molar morphology (HP:0011070)1.52845145
142Abnormality of molar (HP:0011077)1.52845145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.75548806
2MST1R4.70426507
3MAPKAPK33.98908164
4FER3.63889328
5LATS13.41549890
6MAP3K32.79015859
7MAP3K22.72676718
8EPHA22.47624607
9RPS6KB22.22210156
10FRK2.10174679
11RIPK42.04965984
12TRIM282.04837165
13BRSK22.04832021
14PNCK1.97333098
15TRPM71.89902830
16EPHB21.88661483
17IRAK31.87081817
18EPHA41.86209738
19ADRBK21.81897639
20OBSCN1.81358787
21MAP3K91.70556542
22WNK41.64486667
23CASK1.60422624
24TGFBR11.51314942
25WEE11.50788546
26EPHA31.49800624
27BCR1.48933807
28WNK31.48123963
29MET1.42736088
30MAP3K121.41127667
31STK38L1.41020182
32SIK11.40792910
33TAOK11.38812551
34BMPR21.37375443
35TAOK31.25781999
36EEF2K1.23573749
37TESK11.19537690
38EIF2AK11.16195368
39ZAK1.14585016
40MAP3K141.10299910
41PAK31.10103092
42NTRK21.05975585
43MAP3K11.05097184
44PBK1.03076551
45PIK3CA1.02253723
46TLK11.02234886
47ERN10.98280603
48FGFR20.96417336
49INSRR0.94807578
50PIK3CG0.91557974
51MAP3K60.90871046
52ACVR1B0.89674254
53MAPK130.89597547
54MAP3K70.86936955
55PTK2B0.86151523
56PLK20.85190821
57MAP2K40.79973299
58PINK10.79728354
59LATS20.79665783
60FGFR30.76098995
61BMX0.73398477
62ERBB30.72901434
63EIF2AK30.72870948
64MYLK0.69854188
65NEK60.68952162
66PLK40.68190973
67PRKCE0.66219993
68PRKCI0.64573290
69DMPK0.63907697
70EPHB10.63835425
71ERBB40.63709795
72STK380.63364296
73MAPKAPK50.63351728
74STK390.62041431
75PIM20.61941631
76IKBKE0.61935818
77MAP3K110.61916385
78MUSK0.61078937
79AKT30.60413515
80IRAK10.59653340
81BMPR1B0.59417926
82FGFR10.58792317
83DAPK20.57852567
84ERBB20.57768713
85PTK60.57662699
86SGK2230.57068299
87SGK4940.57068299
88PRKAA20.56731028
89NME10.56293126
90RPS6KA40.54799822
91STK100.53436890
92KSR20.53346010
93MAP2K60.52779236
94PRKCG0.52172374
95TNK20.51684312
96STK240.51663574
97PHKG10.51396681
98PHKG20.51396681
99CDK30.49516228
100STK30.49490985
101MAP2K10.49322368
102FGR0.48869584
103MATK0.48658077
104TYRO30.48606881
105MAP3K130.47477796
106BRAF0.46629888
107FGFR40.46442970
108CDK90.46285798
109SGK20.45885396
110ILK0.45118751
111GRK10.44543508
112CSNK1E0.44221395
113TSSK60.42832299
114SIK30.41762620
115NUAK10.40773490
116OXSR10.40667555
117MAP3K50.40599146
118TNIK0.38039097
119MAP4K20.37931679
120MAPKAPK20.37612896
121DYRK30.37564401
122PDK20.37332281
123NTRK10.36947951
124JAK10.36866675
125CDK60.36296758
126JAK30.36079777
127MAPK150.35985763
128NLK0.35008916
129ADRBK10.34747052
130NTRK30.34639002
131SGK10.34176752
132CHUK0.32654363
133LMTK20.31332440
134PRKAA10.28594535
135PRKD20.28156128
136IKBKB0.27701484
137PTK20.26017301
138CSNK1A10.25925977
139RPS6KA10.25830808
140RPS6KB10.25750271
141CSNK1D0.25164638
142MINK10.23915459
143PRKCA0.23869225
144JAK20.23576977
145MAP3K40.23021786
146PRKD10.22878769
147CAMK2A0.22030930

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005912.83388700
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81075639
3Sphingolipid metabolism_Homo sapiens_hsa006002.59909940
4Steroid hormone biosynthesis_Homo sapiens_hsa001402.46711404
5Sulfur metabolism_Homo sapiens_hsa009202.29676198
6Nitrogen metabolism_Homo sapiens_hsa009102.00099610
7Butanoate metabolism_Homo sapiens_hsa006501.99844503
8Collecting duct acid secretion_Homo sapiens_hsa049661.95329374
9Fatty acid biosynthesis_Homo sapiens_hsa000611.95301988
10Arachidonic acid metabolism_Homo sapiens_hsa005901.93362281
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.87754208
12Caffeine metabolism_Homo sapiens_hsa002321.75849465
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.72486643
14Ether lipid metabolism_Homo sapiens_hsa005651.66439621
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.63306094
16Steroid biosynthesis_Homo sapiens_hsa001001.60591712
17Tight junction_Homo sapiens_hsa045301.55362564
18Fatty acid elongation_Homo sapiens_hsa000621.55124717
19beta-Alanine metabolism_Homo sapiens_hsa004101.47787211
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45942088
21Adherens junction_Homo sapiens_hsa045201.45148336
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43587896
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42437114
24Mineral absorption_Homo sapiens_hsa049781.40669559
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.37367190
26Long-term potentiation_Homo sapiens_hsa047201.36926113
27Renin secretion_Homo sapiens_hsa049241.36329706
28Salivary secretion_Homo sapiens_hsa049701.34259989
29GnRH signaling pathway_Homo sapiens_hsa049121.30847568
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28426433
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27936997
32VEGF signaling pathway_Homo sapiens_hsa043701.23945203
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23180565
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21281008
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19866642
36Vibrio cholerae infection_Homo sapiens_hsa051101.18916771
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18248420
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16855126
39Phenylalanine metabolism_Homo sapiens_hsa003601.16309993
40Pancreatic secretion_Homo sapiens_hsa049721.15473703
41Chemical carcinogenesis_Homo sapiens_hsa052041.14018922
42Gastric acid secretion_Homo sapiens_hsa049711.13959567
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13644104
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.10364530
45Tryptophan metabolism_Homo sapiens_hsa003801.10259714
46Sphingolipid signaling pathway_Homo sapiens_hsa040711.09440436
47Peroxisome_Homo sapiens_hsa041461.06358174
48Basal cell carcinoma_Homo sapiens_hsa052171.06184331
49Hippo signaling pathway_Homo sapiens_hsa043901.06089327
50Glutathione metabolism_Homo sapiens_hsa004801.05676047
51Basal transcription factors_Homo sapiens_hsa030221.05607450
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04784850
53Melanogenesis_Homo sapiens_hsa049161.04294242
54Axon guidance_Homo sapiens_hsa043601.03759970
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02195235
56Histidine metabolism_Homo sapiens_hsa003401.01258329
57Vitamin digestion and absorption_Homo sapiens_hsa049770.97101613
58Rheumatoid arthritis_Homo sapiens_hsa053230.96685772
59Serotonergic synapse_Homo sapiens_hsa047260.93353589
60Amphetamine addiction_Homo sapiens_hsa050310.92986337
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92220296
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92161947
63Selenocompound metabolism_Homo sapiens_hsa004500.91313125
64Arginine and proline metabolism_Homo sapiens_hsa003300.90387176
65Phototransduction_Homo sapiens_hsa047440.89611693
66Tyrosine metabolism_Homo sapiens_hsa003500.88252671
67Oxytocin signaling pathway_Homo sapiens_hsa049210.88200502
68Bladder cancer_Homo sapiens_hsa052190.87696094
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87504300
70Taste transduction_Homo sapiens_hsa047420.86818131
71Protein export_Homo sapiens_hsa030600.86590012
72PPAR signaling pathway_Homo sapiens_hsa033200.86329969
73TGF-beta signaling pathway_Homo sapiens_hsa043500.85248737
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83818188
75ErbB signaling pathway_Homo sapiens_hsa040120.82809447
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.82362250
77Olfactory transduction_Homo sapiens_hsa047400.81339996
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81058672
79Retinol metabolism_Homo sapiens_hsa008300.80901173
80Prolactin signaling pathway_Homo sapiens_hsa049170.79837833
81Ras signaling pathway_Homo sapiens_hsa040140.78710895
82Hedgehog signaling pathway_Homo sapiens_hsa043400.78087204
83Long-term depression_Homo sapiens_hsa047300.77933106
84Estrogen signaling pathway_Homo sapiens_hsa049150.77887713
85Circadian rhythm_Homo sapiens_hsa047100.77416283
86Synaptic vesicle cycle_Homo sapiens_hsa047210.77125327
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76725749
88Graft-versus-host disease_Homo sapiens_hsa053320.75321226
89Proteoglycans in cancer_Homo sapiens_hsa052050.75104291
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.74948207
91Calcium signaling pathway_Homo sapiens_hsa040200.74025770
92Pertussis_Homo sapiens_hsa051330.73916408
93ABC transporters_Homo sapiens_hsa020100.72453185
94Glutamatergic synapse_Homo sapiens_hsa047240.72394094
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72386290
96Amoebiasis_Homo sapiens_hsa051460.72007373
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70633558
98Glioma_Homo sapiens_hsa052140.69735303
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69645814
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.69331494
101Glycerolipid metabolism_Homo sapiens_hsa005610.68575532
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68317170
103African trypanosomiasis_Homo sapiens_hsa051430.67531385
104Wnt signaling pathway_Homo sapiens_hsa043100.67354651
105Regulation of autophagy_Homo sapiens_hsa041400.67328399
106TNF signaling pathway_Homo sapiens_hsa046680.66843211
107Hepatitis C_Homo sapiens_hsa051600.66293012
108Dorso-ventral axis formation_Homo sapiens_hsa043200.66234422
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60838049
110Propanoate metabolism_Homo sapiens_hsa006400.60447558
111Circadian entrainment_Homo sapiens_hsa047130.60307269
112Metabolic pathways_Homo sapiens_hsa011000.55339885
113Sulfur relay system_Homo sapiens_hsa041220.54838222
114Platelet activation_Homo sapiens_hsa046110.54631371
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54133877
116Oxidative phosphorylation_Homo sapiens_hsa001900.54057433
117Ovarian steroidogenesis_Homo sapiens_hsa049130.53938418
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53719609
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53538151
120Arginine biosynthesis_Homo sapiens_hsa002200.53127712
121Tuberculosis_Homo sapiens_hsa051520.52176733
122Dopaminergic synapse_Homo sapiens_hsa047280.51453431
123Salmonella infection_Homo sapiens_hsa051320.51174280
124cAMP signaling pathway_Homo sapiens_hsa040240.50927131
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50772546
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50660544
127MicroRNAs in cancer_Homo sapiens_hsa052060.50211248
128ECM-receptor interaction_Homo sapiens_hsa045120.50149982
129p53 signaling pathway_Homo sapiens_hsa041150.49712284
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48512714
131Starch and sucrose metabolism_Homo sapiens_hsa005000.48468425
132Legionellosis_Homo sapiens_hsa051340.48218790
133Fat digestion and absorption_Homo sapiens_hsa049750.47562674
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.46947688
135Insulin secretion_Homo sapiens_hsa049110.46616686
136Bile secretion_Homo sapiens_hsa049760.45744769
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45095385
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44995609
139Nicotine addiction_Homo sapiens_hsa050330.44398561
140Fatty acid degradation_Homo sapiens_hsa000710.43153411
141Prostate cancer_Homo sapiens_hsa052150.42438078
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41724691
143Fanconi anemia pathway_Homo sapiens_hsa034600.40748854
144One carbon pool by folate_Homo sapiens_hsa006700.37326835
145Complement and coagulation cascades_Homo sapiens_hsa046100.32794999
146Choline metabolism in cancer_Homo sapiens_hsa052310.32738625
147Fatty acid metabolism_Homo sapiens_hsa012120.27665505
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27212026
149Cysteine and methionine metabolism_Homo sapiens_hsa002700.26857371
150Homologous recombination_Homo sapiens_hsa034400.25189484

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